Zhen Yan

发表

Molecular mechanisms for mitochondrial adaptation to exercise training in skeletal muscle

Joshua C. Drake, Rebecca J. Wilson, Zhen Yan, 2016, FASEB journal : official publication of the Federation of American Societies for Experimental Biology.

Exercise Stimulates Pgc-1α Transcription in Skeletal Muscle through Activation of the p38 MAPK Pathway*

C. Gumbs, S. Pohnert, R. S. Williams, 2005, Journal of Biological Chemistry.

Mechanical stretch inhibits myoblast-to-adipocyte differentiation through Wnt signaling.

Zhen Yan, Takashi Ushida, Tetsuya Tateishi, 2005, Biochemical and biophysical research communications.

Extracellular superoxide dismutase, a molecular transducer of health benefits of exercise

Zhen Yan, H. Spaulding, 2020, Redox Biology.

Exercise Prevents Maternal High-Fat Diet–Induced Hypermethylation of the Pgc-1α Gene and Age-Dependent Metabolic Dysfunction in the Offspring

J. Connelly, K. Hoehn, Zhen Yan, 2014, Diabetes.

Epigenetic origins of metabolic disease: The impact of the maternal condition to the offspring epigenome and later health consequences

J. Connelly, Zhen Yan, M. Wlodek, 2013 .

Caveolin-1 Deletion Prevents Hypertensive Vascular Remodeling Induced by Angiotensin II

Zhen Yan, S. Eguchi, Steven J Forrester, 2017, Hypertension.

Reactive Oxygen Species/Nitric Oxide Mediated Inter-Organ Communication in Skeletal Muscle Wasting Diseases.

Rebecca J. Wilson, Zhen Yan, A. Gödecke, 2017, Antioxidants & redox signaling.

Skeletal Muscle Fiber-type Switching, Exercise Intolerance, and Myopathy in PGC-1α Muscle-specific Knock-out Animals*

B. Spiegelman, N. LeBrasseur, Sherry Chin, 2007, Journal of Biological Chemistry.

Basal and insul in human must n-mediated carbohydrate metabolism .e deficient in phosphofructokinase I

S. Lillioja, M. Spencer, R. Haller, 1991 .

Intermittent pressure overload triggers hypertrophy-independent cardiac dysfunction and vascular rarefaction.

Hyung-Suk Kim, H. Rockman, S. N. Naga Prasad, 2006, The Journal of clinical investigation.

Atg2, Atg9 and Atg18 in mitochondrial integrity, cardiac function and healthspan in Drosophila.

P. Adler, J. Saucerman, R. Wessells, 2019, Journal of molecular and cellular cardiology.

Nrf2 deficiency in myeloid cells is not sufficient to protect mice from high-fat diet-induced adipose tissue inflammation and insulin resistance.

Masayuki Yamamoto, T. Kensler, N. Leitinger, 2012, Free radical biology & medicine.

Mitochondrial protein S-nitrosation protects against ischemia reperfusion-induced denervation at neuromuscular junction in skeletal muscle

David F. Kashatus, M. Murphy, Joshua C. Drake, 2018, Free radical biology & medicine.

Identification of a novel mitochondrial uncoupler that does not depolarize the plasma membrane.

Ajit S. Divakaruni, J. Holmes, D. Bayliss, 2014, Molecular metabolism.

Voluntary running protects against neuromuscular dysfunction following hindlimb ischemia-reperfusion in mice.

Joshua C. Drake, Rebecca J. Wilson, Zhen Yan, 2019, Journal of applied physiology.

Voluntary Exercise Suppresses Choroidal Neovascularization in Mice

B. Gelfand, J. Ambati, Zhen Yan, 2020, Investigative ophthalmology & visual science.

Calorie restriction and endurance exercise share potent anti-inflammatory function in adipose tissues in ameliorating diet-induced obesity and insulin resistance in mice

Q. Qi, Zhen Yan, Mengle Shao, 2010, Nutrition & metabolism.

and anaplerosis in human skeletal muscle

M. Spencer, A. Katz, Zhen Yan, 1991 .

PGC-1 (cid:1) Promotes Nitric Oxide Antioxidant Defenses and Inhibits FOXO Signaling Against Cardiac Cachexia in Mice

Zhen Yan, T. Geng, Ping Li, 2011 .

Autophagy is involved in adipogenic differentiation by repressesing proteasome-dependent PPARγ2 degradation.

Chongben Zhang, Zhen Yan, L. Ong, 2013, American journal of physiology. Endocrinology and metabolism.

Fiber Type-Specific Nitric Oxide Protects Oxidative Myofibers against Cachectic Stimuli

J. Stamler, Zengli Yu, M. Hannink, 2008, PloS one.

HDAC4 Regulates Muscle Fiber Type-Specific Gene Expression Programs

T. Yao, Zhen Yan, Moon-Chang Choi, 2015, Molecules and cells.

PGC-1alpha plays a functional role in exercise-induced mitochondrial biogenesis and angiogenesis but not fiber-type transformation in mouse skeletal muscle.

Zhen Yan, T. Geng, Ping Li, 2010, American journal of physiology. Cell physiology.

PGC-1 (cid:1) plays a functional role in exercise-induced mitochondrial biogenesis and angiogenesis but not ﬁber-type transformation in mouse skeletal muscle

Zhen Yan, T. Geng, Ping Li, 2010 .

growth are necessary for activity-dependent muscle exercise-induced fiber-type switching and angiogenesis Resident stem cells are not required for

R. S. Williams, Zhen Yan, T. Akimoto, 2009 .

Exercise, PGC-1alpha, and metabolic adaptation in skeletal muscle.

Zhen Yan, 2009, Applied physiology, nutrition, and metabolism = Physiologie appliquee, nutrition et metabolisme.

Transcriptional Control of the Pgc-1&agr; Gene in Skeletal Muscle In Vivo

Zhen Yan, T. Akimoto, Ping Li, 2007 .

Skeletal Muscle Hypertrophy and Response to Training

R. S. Williams, Zhen Yan, 2006 .

Exercise Training-Induced Regulation of Mitochondrial Quality

Zhen Yan, V. Lira, N. Greene, 2012, Exercise and sport sciences reviews.

Real-time imaging of peroxisome proliferator-activated receptor-gamma coactivator-1alpha promoter activity in skeletal muscles of living mice.

B. Sorg, Zhen Yan, T. Akimoto, 2004, American journal of physiology. Cell physiology.

Functional interaction of regulatory factors with the Pgc-1alpha promoter in response to exercise by in vivo imaging.

Zhen Yan, T. Akimoto, Ping Li, 2008, American journal of physiology. Cell physiology.

Exercise-Induced Mitophagy in Skeletal Muscle and Heart.

Joshua C. Drake, Zhen Yan, Yuntian Guan, 2019, Exercise and sport sciences reviews.

Mitophagy in maintaining skeletal muscle mitochondrial proteostasis and metabolic health with ageing

Joshua C. Drake, Zhen Yan, 2017, The Journal of physiology.

Oxidative phenotype protects myofibers from pathological insults induced by chronic heart failure in mice.

L. Mao, Zhen Yan, B. Annex, 2007, The American journal of pathology.

Regulatory circuitry of TWEAK‐Fn14 system and PGC‐1α in skeletal muscle atrophy program

S. Bhatnagar, Ashok Kumar, T. Zheng, 2014, FASEB journal : official publication of the Federation of American Societies for Experimental Biology.

One more trick in the regulation of PGC-1 α

Zhen Yan, 2009 .

Extracellular Superoxide Dismutase Ameliorates Skeletal Muscle Abnormalities, Cachexia, and Exercise Intolerance in Mice with Congestive Heart Failure

Jean A Donet, B. A. French, C. Rembold, 2014, Circulation. Heart failure.

Kruppel-like factor 15 regulates skeletal muscle lipid flux and exercise adaptation

Saptarsi M. Haldar, A. Russell, D. Jeyaraj, 2012, Proceedings of the National Academy of Sciences.

Correction of multiple striated muscles in murine Pompe disease through adeno-associated virus-mediated gene therapy.

R. Auten, Songtao Li, Zhen Yan, 2008, Molecular therapy : the journal of the American Society of Gene Therapy.

Temporal dynamics of the multi-omic response to endurance exercise training across tissues

Michael E. Miller, Ronald J. Moore, Kevin S. Smith, 2022, bioRxiv.

Muscle‐derived extracellular superoxide dismutase inhibits endothelial activation and protects against multiple organ dysfunction syndrome in mice

R. Bowler, Jean A Donet, S. Peirce, 2017, Free radical biology & medicine.

Adeno-associated virus serotype 9 efficiently targets ischemic skeletal muscle following systemic delivery

B. A. French, Zhen Yan, J. Sanders, 2013, Gene Therapy.

Temporal dynamics of the multi-omic response to endurance exercise training across tissues

Michael E. Miller, Ronald J. Moore, Kevin S. Smith, 2022, bioRxiv.

Exercise training improves plantar flexor muscle function in mdx mice.

Zhen Yan, D. Lowe, J. Call, 2012, Medicine and science in sports and exercise.

Response to Comment on Laker et al. Exercise Prevents Maternal High-Fat Diet–Induced Hypermethylation of the Pgc-1α Gene and Age-Dependent Metabolic Dysfunction in the Offspring. Diabetes 2014;63:1605−1611

J. Connelly, Zhen Yan, R. Laker, 2014, Diabetes.

The Mitochondrial Permeability Transition Pore Regulator Cyclophilin D Exhibits Tissue-Specific Control of Metabolic Homeostasis

K. Hoehn, Zhen Yan, E. Taddeo, 2015, PloS one.

Voluntary running induces fiber type-specific angiogenesis in mouse skeletal muscle.

Zhen Yan, B. Annex, Ping Li, 2004, American journal of physiology. Cell physiology.

p38γ Mitogen-Activated Protein Kinase Is a Key Regulator in Skeletal Muscle Metabolic Adaptation in Mice

J. Chi, Zhen Yan, T. Geng, 2009, PloS one.

Possible roles for ATP release from RBCs exclude the cAMP-mediated Panx1 pathway.

Joshua C. Drake, Zhen Yan, M. Kelm, 2017, American journal of physiology. Cell physiology.

Autophagy is required for exercise training‐induced skeletal muscle adaptation and improvement of physical performance

K. Hoehn, Zhen Yan, Mei Zhang, 2013, FASEB journal : official publication of the Federation of American Societies for Experimental Biology.

Structural modulation of gut microbiota in life-long calorie-restricted mice

Liping Zhao, Menghui Zhang, Shengyue Wang, 2013, Nature Communications.

Peroxisome Proliferator-activated Receptor-γ Co-activator 1α-mediated Metabolic Remodeling of Skeletal Myocytes Mimics Exercise Training and Reverses Lipid-induced Mitochondrial Inefficiency*

Ping Li, Olga Ilkayeva, O. Ilkayeva, 2005, Journal of Biological Chemistry.

Deletion of the Protein Kinase A/Protein Kinase G Target SMTNL1 Promotes an Exercise-adapted Phenotype in Vascular Smooth Muscle*

T. Haystead, M. Datto, T. Gavin, 2008, Journal of Biological Chemistry.

Ampk phosphorylation of Ulk1 is required for targeting of mitochondria to lysosomes in exercise-induced mitophagy

J. Saucerman, L. Goodyear, M. Kundu, 2017, Nature Communications.

Endurance Exercise and the Regulation of Skeletal Muscle Metabolism.

F. Booth, Zhen Yan, Ryan G. Toedebusch, 2015, Progress in molecular biology and translational science.

activity in skeletal muscles of living mice receptor-{gamma} coactivator-1{alpha} promoter Real-time imaging of peroxisome proliferator-activated

B. Sorg, Zhen Yan, A. Garnier, 2009 .

Skeletal muscle adaptation in response to voluntary running in Ca2+/calmodulin-dependent protein kinase IV-deficient mice.

R. S. Williams, Zhen Yan, T. Akimoto, 2004, American journal of physiology. Cell physiology.

Real-time imaging of peroxisome proliferator-activated receptor-γ coactivator-1α promoter activity in skeletal muscles of living mice

B. Sorg, Zhen Yan, T. Akimoto, 2004 .

Highly Coordinated Gene Regulation in Mouse Skeletal Muscle Regeneration* 210

Ling Lin, Sun Young Lee, Sangdun Choi, 2003, The Journal of Biological Chemistry.

A Novel MitoTimer Reporter Gene for Mitochondrial Content, Structure, Stress, and Damage in Vivo*

M. Driscoll, P. Adler, J. Saucerman, 2014, The Journal of Biological Chemistry.

Midlife gene expressions identify modulators of aging through dietary interventions

Matt Kaeberlein, Zhen Yan, Christopher D. Green, 2012, Proceedings of the National Academy of Sciences.

Translational Suppression of Atrophic Regulators by MicroRNA-23a Integrates Resistance to Skeletal Muscle Atrophy*

Takashi Ushida, Shogo Wada, Yoshio Kato, 2011, The Journal of Biological Chemistry.

A PGC-1α Isoform Induced by Resistance Training Regulates Skeletal Muscle Hypertrophy

B. Spiegelman, B. Harrison, L. Leinwand, 2012, Cell.

Liping Huang, David F. Kashatus, Rebecca J. Wilson, 2017, Journal of the American Society of Nephrology : JASN.

angiogenesis in skeletal muscle transformation, mitochondrial biogenesis, and Regulation of exercise-induced fiber type

S. Kajimura, S. Riechman, J. Fluckey, 2011 .

Regulation of exercise-induced fiber type transformation, mitochondrial biogenesis, and angiogenesis in skeletal muscle.

Zhen Yan, V. Lira, M. Okutsu, 2011, Journal of applied physiology.

Total skeletal muscle PGC-1 deficiency uncouples mitochondrial derangements from fiber type determination and insulin sensitivity.

C. Zechner, D. Wozniak, Zhen Yan, 2010, Cell metabolism.

PGC-1alpha regulation by exercise training and its influences on muscle function and insulin sensitivity.

A. Bonen, Zhen Yan, Zhen Yan, 2010, American journal of physiology. Endocrinology and metabolism.

PGC-1 regulation by exercise training and its influences on muscle function and insulin sensitivity

A. Bonen, Zhen Yan, V. Lira, 2010 .

Exercise , PGC-1 a , and metabolic adaptation in skeletal muscle 1

Zhen Yan, 2009 .

BAF60c drives glycolytic muscle formation and improves glucose homeostasis through Deptor-mediated AKT activation

Jiandie D. Lin, Si-ming Li, Z. Meng, 2013, Nature Medicine.

Exercise leads to unfavourable cardiac remodelling and enhanced metabolic homeostasis in obese mice with cardiac and skeletal muscle autophagy deficiency

Zhen Yan, R. Pereira, J. Call, 2017, Scientific Reports.

Enhanced Skeletal Muscle Expression of Extracellular Superoxide Dismutase Mitigates Streptozotocin-Induced Diabetic Cardiomyopathy by Reducing Oxidative Stress and Aberrant Cell Signaling

Zhen Yan, Kyle S. Martin, J. Call, 2015, Circulation. Heart failure.

Muscle-specific activation of Ca2+/calmodulin-dependent protein kinase IV increases whole-body insulin action in mice

G. Shulman, R. S. Williams, Dongyan Zhang, 2014, Diabetologia.

angiogenesis in mouse skeletal muscle Voluntary running induces fiber type-specific

Zhen Yan, B. Annex, Ping Li, 2004 .

Ulk1-mediated autophagy plays an essential role in mitochondrial remodeling and functional regeneration of skeletal muscle.

M. Kundu, Rebecca J. Wilson, Zhen Yan, 2017, American journal of physiology. Cell physiology.

TRPC3 channels confer cellular memory of recent neuromuscular activity.

R. Bassel-Duby, J. Shelton, R. S. Williams, 2004, Proceedings of the National Academy of Sciences of the United States of America.

PR48, a Novel Regulatory Subunit of Protein Phosphatase 2A, Interacts with Cdc6 and Modulates DNA Replication in Human Cells

Zhen Yan, M. Mumby, R. S. Williams, 2000, Molecular and Cellular Biology.

Disconnecting mitochondrial content from respiratory chain capacity in PGC-1-deficient skeletal muscle.

P. Rustin, L. Goodyear, M. Hirshman, 2013, Cell reports.

Voluntary running suppresses proinflammatory cytokines and bone marrow endothelial progenitor cell levels in apolipoprotein-E-deficient mice.

E. Herderick, Zhen Yan, P. Goldschmidt-Clermont, 2009, Antioxidants & redox signaling.

A novel voluntary weightlifting model in mice promotes muscle adaptation and insulin sensitivity with simultaneous enhancement of autophagy and mTOR pathway

C. Farber, S. Rich, Joshua C. Drake, 2020, FASEB journal : official publication of the Federation of American Societies for Experimental Biology.

Resident stem cells are not required for exercise-induced fiber-type switching and angiogenesis but are necessary for activity-dependent muscle growth.

R. S. Williams, Zhen Yan, T. Akimoto, 2006, American journal of physiology. Cell physiology.

miR-26a is required for skeletal muscle differentiation and regeneration in mice.

Anindya Dutta, Zhen Yan, B. Dey, 2012, Genes & development.

Myocyte Specific Overexpression of Myoglobin Impairs Angiogenesis After Hind-Limb Ischemia

J. Stamler, A. Aldrich, Zhen Yan, 2008, Arteriosclerosis, thrombosis, and vascular biology.

Ulk1, Not Ulk2, Is Required for Exercise Training-Induced Improvement of Insulin Response in Skeletal Muscle

M. Kundu, Joshua C. Drake, Rebecca J. Wilson, 2021, Frontiers in Physiology.

Targeting healthspan to optimally combat non-communicable disease in an aging world

Joshua C. Drake, Zhen Yan, 2019, Sports medicine and health science.

Mitochondria-localized AMPK responds to local energetics and contributes to exercise and energetic stress-induced mitophagy

Clint L. Miller, G. Christ, D. Hardie, 2021, Proceedings of the National Academy of Sciences.

Transcriptional profiling in mouse skeletal muscle following a single bout of voluntary running: evidence of increased cell proliferation.

Sun Young Lee, Sangdun Choi, Zhen Yan, 2005, Journal of applied physiology.

Induction of osteoarthritis and metabolic inflammation by a very high-fat diet in mice: effects of short-term exercise.

T. Griffin, F. Guilak, Zhen Yan, 2012, Arthritis and rheumatism.

musclegene transcription in denervated skeletal Regulation of glucose transporters GLUT-4 and

C. Gomez, R. Bassel-Duby, C. Newgard, 2015 .

Conditional Expression of SV40 T-antigen in Mouse Cardiomyocytes Facilitates an Inducible Switch from Proliferation to Differentiation* 210

E. Olson, R. Bassel-Duby, R. S. Williams, 2003, The Journal of Biological Chemistry.

Exercise leads to unfavourable cardiac remodelling and enhanced metabolic homeostasis in obese mice with cardiac and skeletal muscle autophagy deficiency

Zhen Yan, R. Pereira, J. Call, 2017, Scientific Reports.

Conditional MitoTimer reporter mice for assessment of mitochondrial structure, oxidative stress, and mitophagy

David F. Kashatus, P. Scherer, Joshua C. Drake, 2017, Mitochondrion.

Exercise-induced mitophagy in skeletal muscle occurs in the absence of stabilization of Pink1 on mitochondria

Joshua C. Drake, Rebecca J. Wilson, Zhen Yan, 2019, Cell cycle.

Lysophosphatidic acid counteracts glucagon-induced hepatocyte glucose production via STAT3

K. Hoehn, T. Harris, Zhen Yan, 2017, Scientific Reports.

Precision remodeling: how exercise improves mitochondrial quality in myofibers.

Joshua C. Drake, Zhen Yan, 2019, Current opinion in physiology.

Long-term voluntary running prevents the onset of symptomatic Friedreich’s ataxia in mice

Joshua C. Drake, Rebecca J. Wilson, Zhen Yan, 2020, Scientific Reports.

Involvement of mTOR in Type 2 CRF Receptor Inhibition of Insulin Signaling in Muscle Cells.

T. Harris, Zhen Yan, V. Lira, 2015, Molecular endocrinology.

Exercise during pregnancy mitigates negative effects of parental obesity on metabolic function in adult mouse offspring.

C. Farber, J. Connelly, S. Rich, 2020, Journal of applied physiology.

Transcriptional control of the Pgc-1alpha gene in skeletal muscle in vivo.

Zhen Yan, T. Akimoto, Ping Li, 2007, Exercise and sport sciences reviews.

Opening of the mitochondrial permeability transition pore links mitochondrial dysfunction to insulin resistance in skeletal muscle.

D. James, N. Turner, K. Hoehn, 2014, Molecular metabolism.

Surgical Induction of HindLimb Ischemia and Hemodynamic Assessment

J. Stamler, A. Aldrich, Zhen Yan, 2008 .

Myocyte Specific Overexpression of Myoglobin Impairs Angiogenesis After HindLimb

J. Stamler, A. Aldrich, Zhen Yan, 2008 .

Temporal dynamics of the multi-omic response to endurance exercise training across tissues

Michael E. Miller, Ronald J. Moore, Ian R. Lanza, 2023, bioRxiv.

The CaV 1.2 Ca2+ channel is expressed in sarcolemma of type I and IIa myofibers of adult skeletal muscle

M. Rich, C. Norris, Zhen Yan, 2007, Muscle & nerve.

Exercise-induced mitophagy in skeletal muscle occurs in the absence of stabilization of Pink1 on mitochondria

Joshua C. Drake, Rebecca J. Wilson, Zhen Yan, 2018, Cell cycle.

Exercise Prevents Maternal High-Fat Diet–Induced Hypermethylation of the Pgc-1α Gene and Age-Dependent Metabolic Dysfunction in the Offspring

J. Connelly, Zhen Yan, Mei Zhang, 2014, Diabetes.

Endurance Exercise and the Regulation of Skeletal Muscle Metabolism.

F. Booth, Zhen Yan, Ryan G. Toedebusch, 2015, Progress in molecular biology and translational science.

Autophagy is required for exercise training‐induced skeletal muscle adaptation and improvement of physical performance

Zhen Yan, Mei Zhang, V. Lira, 2013, FASEB journal : official publication of the Federation of American Societies for Experimental Biology.

Voluntary running protects against neuromuscular dysfunction following hindlimb ischemia-reperfusion in mice.

Joshua C. Drake, Rebecca J. Wilson, Zhen Yan, 2019, Journal of applied physiology.

PGC-1 (cid:1) plays a functional role in exercise-induced mitochondrial biogenesis and angiogenesis but not ﬁber-type transformation in mouse skeletal muscle

Zhen Yan, T. Geng, Ping Li, 2010 .

A PGC-1α Isoform Induced by Resistance Training Regulates Skeletal Muscle Hypertrophy

Ian R. Lanza, B. Spiegelman, B. Harrison, 2012, Cell.

Enhanced Skeletal Muscle Expression of Extracellular Superoxide Dismutase Mitigates Streptozotocin-Induced Diabetic Cardiomyopathy by Reducing Oxidative Stress and Aberrant Cell Signaling

Zhen Yan, Kyle S. Martin, J. Call, 2015, Circulation. Heart failure.