Xiaofen Li

发表

Exploring the Inhibitory Mechanism of Approved Selective Norepinephrine Reuptake Inhibitors and Reboxetine Enantiomers by Molecular Dynamics Study

Feng Zhu, Weiwei Xue, Xiaojun Yao, 2016, Scientific Reports.

Computational identification of the binding mechanism of a triple reuptake inhibitor amitifadine for the treatment of major depressive disorder.

Feng Zhu, Weiwei Xue, Xiaojun Yao, 2018, Physical chemistry chemical physics : PCCP.

Exploring the Binding Mechanism of Metabotropic Glutamate Receptor 5 Negative Allosteric Modulators in Clinical Trials by Molecular Dynamics Simulations.

Feng Zhu, Weiwei Xue, Xiaojun Yao, 2018, ACS chemical neuroscience.

Prediction of the binding mode and resistance profile for a dual-target pyrrolyl diketo acid scaffold against HIV-1 integrase and reverse-transcriptase-associated ribonuclease H.

Feng Zhu, Weiwei Xue, Xiaojun Yao, 2018, Physical chemistry chemical physics : PCCP.

Metabolism and Disposition of a Novel Selective α7 Neuronal Acetylcholine Receptor Agonist ABT-126 in Humans: Characterization of the Major Roles for Flavin-Containing Monooxygenases and UDP-Glucuronosyl Transferase 1A4 and 2B10 in Catalysis

J. Sydor, Xiaofen Li, Hong Liu, 2018, Drug Metabolism and Disposition.

Original Article Gambogic acid moderates cardiac responses to chronic hypoxia likely by acting on the proteasome and NF-κB pathway

Jinbao Liu, Xiaofen Li, Xuejun Wang, 2013 .

Gambogic acid moderates cardiac responses to chronic hypoxia likely by acting on the proteasome and NF-κB pathway.

Jinbao Liu, Xiaofen Li, Xuejun Wang, 2013, American journal of cardiovascular disease.

Gambogic acid suppresses pressure overload cardiac hypertrophy in rats.

Jinbao Liu, Xiaofen Li, Xuejun Wang, 2013, American journal of cardiovascular disease.

HDAC Inhibitor L-Carnitine and Proteasome Inhibitor Bortezomib Synergistically Exert Anti-Tumor Activity In Vitro and In Vivo

B. Li, Q. Dou, Jinbao Liu, 2012, PloS one.

Repurposing an antidandruff agent to treating cancer: zinc pyrithione inhibits tumor growth via targeting proteasome-associated deubiquitinases

D. Zang, Jinbao Liu, Xiaofen Li, 2017, Oncotarget.

Disposition and Drug-Drug Interaction Potential of Veliparib (ABT-888), a Novel and Potent Inhibitor of Poly(ADP-ribose) Polymerase

S. D. de Morais, Xiaofen Li, R. Voorman, 2011, Drug Metabolism and Disposition.

Dioscin and diosgenin: insights into their potential protective effects in cardiac diseases.

Xiaofen Li, Liping Qu, Wenjun Zou, 2021, Journal of ethnopharmacology.

Intracellular ATP Concentration Contributes to the Cytotoxic and Cytoprotective Effects of Adenosine

Jinbao Liu, Xiaofen Li, Hongbiao Huang, 2013, PloS one.

Novel 1,3-dipropyl-8-(1-heteroarylmethyl-1H-pyrazol-4-yl)-xanthine derivatives as high affinity and selective A2B adenosine receptor antagonists.

David A. Lustig, Xiaofen Li, E. Elzein, 2006, Bioorganic & medicinal chemistry letters.

Anti-rheumatic agent auranofin induced apoptosis in chronic myeloid leukemia cells resistant to imatinib through both Bcr/Abl-dependent and -independent mechanisms

Quentin Liu, D. Zang, Jinbao Liu, 2014, Oncotarget.

Short Term Exposure to Bilirubin Induces Encephalopathy Similar to Alzheimer's Disease in Late Life.

Jinbao Liu, Xiaofen Li, Xuejun Wang, 2019, Journal of Alzheimer's disease : JAD.

Selective, high affinity A(2B) adenosine receptor antagonists: N-1 monosubstituted 8-(pyrazol-4-yl)xanthines.

Xiaofen Li, E. Elzein, D. Zeng, 2008, Bioorganic & medicinal chemistry letters.

Discovery of Dihydrobenzoxazepinone (GS-6615) Late Sodium Current Inhibitor (Late INai), a Phase II Agent with Demonstrated Preclinical Anti-Ischemic and Antiarrhythmic Properties.

M. Desai, Xiaofen Li, Tetsuya Kobayashi, 2016, Journal of medicinal chemistry.

N6-Cycloalkyl-2-substituted adenosine derivatives as selective, high affinity adenosine A1 receptor agonists.

Xiaofen Li, E. Elzein, D. Zeng, 2007, Bioorganic & medicinal chemistry letters.

Bisphosphonate‐enoxacin inhibit osteoclast formation and function by abrogating RANKL‐induced JNK signalling pathways during osteoporosis treatment

Xiaofen Li, M. Dai, P. Zhan, 2021, Journal of cellular and molecular medicine.

Plasmodium infection prevents recurrence and metastasis of hepatocellular carcinoma possibly via inhibition of the epithelial-mesenchymal transition

L. Qin, Xiaofen Li, Xiaoping Chen, 2021, Molecular medicine reports.

Bilirubin neurotoxicity is associated with proteasome inhibition

Jinbao Liu, Y. Nie, P. Zhou, 2017, Cell Death & Disease.

Microsoft Word-63977257-file00

S. D. de Morais, Xiaofen Li, R. Voorman, 2011 .

Two clinical drugs deubiquitinase inhibitor auranofin and aldehyde dehydrogenase inhibitor disulfiram trigger synergistic anti-tumor effects in vitro and in vivo

D. Zang, Jinbao Liu, Xiaofen Li, 2015, Oncotarget.

Design, synthesis and neuroprotective activities of novel cinnamide derivatives containing benzylpiperazine moiety

Xiaofen Li, Aixia Zhang, Y. Zhong, 2018, Medicinal Chemistry Research.

Discovery of 2-[4-{{2-(2S,5R)-2-cyano-5-ethynyl-1-pyrrolidinyl]-2-oxoethyl]amino]- 4-methyl-1-piperidinyl]-4-pyridinecarboxylic acid (ABT-279): a very potent, selective, effective, and well-tolerated inhibitor of dipeptidyl peptidase-IV, useful for the treatment of diabetes.

K. Longenecker, J. Segreti, H. Sham, 2006, Journal of medicinal chemistry.

2-tert-butyl-1,4-benzoquinone Induces Apoptosis in Chronic MyeloidLeukemia Cells Resistant to Imatinib via Inducing Caspase-Dependent Bcr-Abl Downregulation

Jinbao Liu, B. Carter, Xiaofen Li, 2014 .

2-tert-butyl-1,4-benzoquinone Induces Apoptosis in Chronic Myeloid Leukemia Cells Resistant to Imatinib via Inducing Caspase-Dependent Bcr-

Jinbao Liu, B. Carter, Xiaofen Li, 2014 .

Gambogic Acid Induces Apoptosis in Imatinib-Resistant Chronic Myeloid Leukemia Cells via Inducing Proteasome Inhibition and Caspase-Dependent Bcr-Abl Downregulation

Q. Dou, Jinbao Liu, P. Zhou, 2013, Clinical Cancer Research.

Gambogic acid is a tissue-specific proteasome inhibitor in vitro and in vivo.

Q. Dou, Jinbao Liu, P. Zhou, 2013, Cell reports.

Discovery of triazolopyridinone GS-462808, a late sodium current inhibitor (Late INai) of the cardiac Nav1.5 channel with improved efficacy and potency relative to ranolazine.

Xiaofen Li, Tetsuya Kobayashi, S. Rajamani, 2016, Bioorganic & medicinal chemistry letters.

Plasmodium infection inhibits triple negative 4T1 breast cancer potentially through induction of CD8+ T cell-mediated antitumor responses in mice.

L. Qin, Xiaofen Li, Xiaoping Chen, 2021, Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie.

The combination of proteasome inhibitors bortezomib and gambogic acid triggers synergistic cytotoxicity in vitro but not in vivo.

Jinbao Liu, Xiaofen Li, Hongbiao Huang, 2014, Toxicology letters.

Discovery of a novel A2B adenosine receptor antagonist as a clinical candidate for chronic inflammatory airway diseases.

David A. Lustig, Xiaofen Li, E. Elzein, 2008, Journal of medicinal chemistry.

Anacardic acid induces cell apoptosis associated with induction of ATF4-dependent endoplasmic reticulum stress.

Jinbao Liu, Xiaofen Li, Hongbiao Huang, 2014, Toxicology letters.

Plasmodium infection prevents recurrence and metastasis of hepatocellular carcinoma potentially via inhibiting EMT

Xiaofen Li, Xiaoping Chen, Zhu Tao, 2020 .

Sanggenon C decreases tumor cell viability associated with proteasome inhibition.

Q. Dou, Jinbao Liu, P. Zhou, 2011, Frontiers in bioscience.

Epidemiological analysis of varicella in Dalian from 2009 to 2019 and application of three kinds of model in prediction prevalence of varicella

Xiaofen Li, Xian-ce Sun, Yu Bai, 2021, BMC Public Health.

Title : Metabolism and Disposition of a Novel Selective 7 Neuronal Acetylcholine Receptor Agonist ABT-126 in Humans : Characterization of the Major Roles for Flavin-containing Monooxygenases and UDP-glucuronosyl Transferase 1 A 4 and 2 B 10 in Catalysis

J. Sydor, Xiaofen Li, Hong Liu, 2018 .

Discovery and structure-activity relationships of piperidinone- and piperidine-constrained phenethylamines as novel, potent, and selective dipeptidyl peptidase IV inhibitors.

K. Longenecker, H. Sham, Xiaofen Li, 2007, Journal of medicinal chemistry.

CVT-4325: a potent fatty acid oxidation inhibitor with favorable oral bioavailability.

David A. Lustig, S. Kerwar, Xiaofen Li, 2004, Bioorganic & medicinal chemistry letters.

Clinically used antirheumatic agent auranofin is a proteasomal deubiquitinase inhibitor and inhibits tumor growth

Ping Zhou, Wenbin Song, Li Xu, 2014, Oncotarget.

4-Aryl Pyrrolidines as Novel Orally Efficacious Antimalarial Agents. Part 2: 2-Aryl-N-(4-arylpyrrolidin-3-yl)acetamides.

Xiaofen Li, Hongwei Ma, Jianguang Liu, 2019, ACS Medicinal Chemistry Letters.

4-Aryl Pyrrolidines as a Novel Class of Orally Efficacious Antimalarial Agents. Part 1: Evaluation of 4-Aryl- N-benzylpyrrolidine-3-carboxamides.

J. Xu, D. Goldberg, Xiaofen Li, 2019, Journal of medicinal chemistry.

Regulation of Bax-dependent apoptosis by mitochondrial deubiquitinase USP30

Q. Dou, Jinbao Liu, Xiaofen Li, 2021, Cell death discovery.

A novel proteasome inhibitor suppresses tumor growth via targeting both 19S proteasome deubiquitinases and 20S proteolytic peptidases

Q. Dou, Jinbao Liu, P. Zhou, 2014, Scientific Reports.

Advances in HPLC detection—towards universal detection

Bing Yan, Bin Zhang, B. Yan, 2008, Analytical and bioanalytical chemistry.

Discovery of ((4R,5S)-5-amino-4-(2,4,5- trifluorophenyl)cyclohex-1-enyl)-(3- (trifluoromethyl)-5,6-dihydro- [1,2,4]triazolo[4,3-a]pyrazin-7(8H)-yl)methanone (ABT-341), a highly potent, selective, orally efficacious, and safe dipeptidyl peptidase IV inhibitor for the treatment of type 2 diabetes.

K. Longenecker, H. Sham, R. Fryer, 2006, Journal of medicinal chemistry.

Gambogic acid induces apoptosis in diffuse large B-cell lymphoma cells via inducing proteasome inhibition

D. Zang, Jinbao Liu, Xiaofen Li, 2015, Scientific Reports.

In vitro OATP1B1 and OATP1B3 inhibition is associated with observations of benign clinical unconjugated hyperbilirubinemia

S. D. de Morais, Xiaofen Li, R. Voorman, 2014, Xenobiotica; the fate of foreign compounds in biological systems.

Consistent gene signature of schizophrenia identified by a novel feature selection strategy from comprehensive sets of transcriptomic data

Xiaofeng Li, Feng Zhu, Yunxia Wang, 2019, Briefings Bioinform..

Gambogic acid enhances proteasome inhibitor-induced anticancer activity.

Di Chen, Q. Dou, Jinbao Liu, 2011, Cancer letters.

L-Carnitine Is an Endogenous HDAC Inhibitor Selectively Inhibiting Cancer Cell Growth In Vivo and In Vitro

Bing Li, Wenbin Song, Li Xu, 2012, PloS one.

Novel 1,3-disubstituted 8-(1-benzyl-1H-pyrazol-4-yl) xanthines: high affinity and selective A2B adenosine receptor antagonists.

Xiaofen Li, E. Elzein, D. Zeng, 2006, Journal of medicinal chemistry.

A new gold(I) complex-Au(PPh3)PT is a deubiquitinase inhibitor and inhibits tumor growth

Jinbao Liu, Xiaofen Li, H. Su, 2018, EBioMedicine.

Copper-dependent autophagic degradation of GPX4 drives ferroptosis

D. Klionsky, G. Kroemer, Jinbao Liu, 2023, Autophagy.

Preparation and evaluation of new l-canavanine derivatives as nitric oxide synthase inhibitors

Xiaofen Li, R. Atkinson, S. King, 2001 .

Platinum-containing compound platinum pyrithione is stronger and safer than cisplatin in cancer therapy

D. Zang, Jinbao Liu, Zhiming He, 2016, Biochemical pharmacology.

Bilirubin inhibits the anticancer activity of sorafenib by blocking MCL-1 degradation in hepatocellular carcinoma cells

Jinbao Liu, D. Tang, Xiaofen Li, 2022, Cancer biology & medicine.

Plasmodium infection inhibits the expansion and activation of MDSCs and Tregs in the tumor microenvironment in a murine Lewis lung cancer model

Xiaofen Li, K. Gadidasu, Xiaoping Chen, 2019, Cell communication and signaling : CCS.

Evaluation of copper-dependent proteasome-inhibitory and apoptosis-inducing activities of novel pyrrolidine dithiocarbamate analogues.

Q. Dou, Xiaofen Li, B. Yan, 2007, International journal of molecular medicine.

A microRNA-mediated decrease in eukaryotic initiation factor 2α promotes cell survival during PS-341 treatment

D. Zang, Jinbao Liu, Xiaofen Li, 2016, Scientific Reports.

Identification of a monoacid-based, cell permeable, selective inhibitor of protein tyrosine phosphatase 1B.

P. Hajduk, C. Abad-Zapatero, Xiaofen Li, 2003, Bioorganic & medicinal chemistry letters.

Discovery and SAR of novel, potent and selective protein tyrosine phosphatase 1B inhibitors.

Gang Liu, C. Abad-Zapatero, Xiaofen Li, 2003, Bioorganic & medicinal chemistry letters.

Discovery of potent and selective inhibitors of calmodulin-dependent kinase II (CaMKII).

J. R. Somoza, Xiaofen Li, N. Pagratis, 2017, Bioorganic & medicinal chemistry letters.

Plasmodium infection inhibits the expansion and activation of MDSCs and Tregs in the tumor microenvironment in a murine Lewis lung cancer model

Xiaofen Li, K. Gadidasu, Xiaoping Chen, 2019, Cell Communication and Signaling.

A novel nickel complex works as a proteasomal deubiquitinase inhibitor for cancer therapy

D. Zang, Q. Dou, Jinbao Liu, 2016, Oncogene.

Discovery, structure-activity relationship, and pharmacological evaluation of (5-substituted-pyrrolidinyl-2-carbonyl)-2-cyanopyrrolidines as potent dipeptidyl peptidase IV inhibitors.

H. Sham, Xiaofen Li, D. Beno, 2006, Journal of Medicinal Chemistry.

Calcium channel blocker verapamil accelerates gambogic acid-induced cytotoxicity via enhancing proteasome inhibition and ROS generation.

Q. Dou, Jinbao Liu, Xiaofen Li, 2014, Toxicology in vitro : an international journal published in association with BIBRA.

In vitro OATP1B1 and OATP1B3 inhibition is associated with observations of benign clinical unconjugated hyperbilirubinemia

S. D. de Morais, Xiaofen Li, R. Voorman, 2014, Xenobiotica; the fate of foreign compounds in biological systems.