C. Loland

发表

Structure–activity relationship studies of citalopram derivatives: examining substituents conferring selectivity for the allosteric site in the 5‐HT transporter

K. Bogeso, U. Gether, M. Larsen, 2016, British journal of pharmacology.

Maltose-neopentyl glycol (MNG) amphiphiles for solubilization, stabilization and crystallization of membrane proteins

Daniel Picot, Brian G. Fox, Lan Guan, 2010, Nature Methods.

The binding sites for cocaine and dopamine in the dopamine transporter overlap

H. Weinstein, Lei Shi, J. Javitch, 2008, Nature Neuroscience.

SLC6 Neurotransmitter Transporters: Structure, Function, and Regulation

U. Gether, Jacob Andersen, A. Kristensen, 2011, Pharmacological Reviews.

Elucidating the Mechanism Behind Sodium-Coupled Neurotransmitter Transporters by Reconstitution

U. Gether, C. Loland, Solveig G Schmidt, 2021, Neurochemical research.

X-ray structure of LeuT in an inward-facing occluded conformation reveals mechanism of substrate release

Michael V. LeVine, Daniel S. Terry, H. Weinstein, 2020, Nature Communications.

Substrate-induced conformational dynamics of the dopamine transporter

K. Lindorff-Larsen, S. Rasmussen, Yong Wang, 2019, Nature Communications.

Conformational dynamics of the human serotonin transporter during substrate and drug binding

S. Rasmussen, U. Gether, C. Loland, 2019, Nature Communications.

Partial Unwinding of Transmembrane Helices Facilitates Alternating Access in the Neurotransmitter:Sodium Symporter LeuT

M. Cuendet, U. Gether, C. Loland, 2017, bioRxiv.

Direct assessment of substrate binding to the Neurotransmitter:Sodium Symporter LeuT by solid state NMR

F. H. Larsen, H. Oschkinat, K. Teilum, 2017, eLife.

Conformational Dynamics on the Extracellular Side of LeuT Controlled by Na+ and K+ Ions and the Protonation State of Glu290*

H. Weinstein, Lei Shi, J. Javitch, 2016, The Journal of Biological Chemistry.

A Conserved Salt Bridge between Transmembrane Segments 1 and 10 Constitutes an Extracellular Gate in the Dopamine Transporter*

Thorvald F. Andreassen, C. Loland, A. V. Pedersen, 2014, The Journal of Biological Chemistry.

A virtual high-throughput screening approach to the discovery of novel inhibitors of the bacterial leucine transporter, LeuT

C. Fishwick, A. Johnson, K. Simmons, 2013, Molecular membrane biology.

Generation of an activating Zn2+ switch in the dopamine transporter: Mutation of an intracellular tyrosine constitutively alters the conformational equilibrium of the transport cycle

T. Litman, U. Gether, C. Loland, 2002, Proceedings of the National Academy of Sciences of the United States of America.

Design and synthesis of 1-(3-(dimethylamino)propyl)-1-(4-fluorophenyl)-1,3-dihydroisobenzofuran-5-carbonitrile (citalopram) analogues as novel probes for the serotonin transporter S1 and S2 binding sites.

A. Newman, P. Plenge, C. Loland, 2013, Journal of medicinal chemistry.

Probing dopamine transporter structure and function by Zn2+-site engineering.

U. Gether, C. Loland, K. Norgaard-Nielsen, 2003, European journal of pharmacology.

Navigating through chemical space and evolutionary time across the Australian continent in plant genus Eremophila

Chi P. Ndi, B. Møller, D. Murphy, 2020, bioRxiv.

Neuropeptide Y Y5 receptor antagonism attenuates cocaine-induced effects in mice

A. Fink-Jensen, G. Wörtwein, C. Loland, 2012, Psychopharmacology.

Surface Targeting of the Dopamine Transporter Involves Discrete Epitopes in the Distal C Terminus But Does Not Require Canonical PDZ Domain Interactions

J. Javitch, U. Gether, C. Loland, 2004, The Journal of Neuroscience.

Structural probing of a microdomain in the dopamine transporter by engineering of artificial Zn2+ binding sites.

H Weinstein, J. Ballesteros, H. Weinstein, 2000, Biochemistry.

Intramolecular cross-linking in a bacterial homolog of mammalian SLC6 neurotransmitter transporters suggests an evolutionary conserved role of transmembrane segments 7 and 8

H. Sitte, J. Javitch, M. Quick, 2005, Neuropharmacology.

Insights From Endogenous and Engineered Zn2+ Binding Sites in Monoamine Transporters

U. Gether, C. Loland, 2004 .

Evidence for Distinct Sodium-, Dopamine-, and Cocaine-dependent Conformational Changes in Transmembrane Segments 7 and 8 of the Dopamine Transporter*

U. Gether, C. Loland, L. Norregaard, 2003, Journal of Biological Chemistry.

Engineered Zn(2+) switches in the gamma-aminobutyric acid (GABA) transporter-1. Differential effects on GABA uptake and currents.

U. Gether, C. Loland, N. MacAulay, 2001, The Journal of biological chemistry.

Missense dopamine transporter mutations associate with adult parkinsonism and ADHD.

Thorvald F. Andreassen, H. Weinstein, H. Sitte, 2014, The Journal of clinical investigation.

Regulation of Dopamine Transporter Trafficking by Intracellular Amphetamine

J. Javitch, A. Galli, U. Gether, 2006, Molecular Pharmacology.

Diastereomeric Cyclopentane-Based Maltosides (CPMs) as Tools for Membrane Protein Study.

P. S. Chae, B. Kobilka, B. Byrne, 2020, Journal of the American Chemical Society.

The dopamine transporter antiports potassium to increase the uptake of dopamine

N. Hatzakis, C. Loland, K. Rand, 2022, Nature Communications.

The dopamine transporter counter-transports potassium to increase the uptake of dopamine

N. Hatzakis, C. Loland, K. Rand, 2021 .

Elucidation of Structural Elements for Selectivity across Monoamine Transporters: Novel 2-[(Diphenylmethyl)sulfinyl]acetamide (Modafinil) Analogues

A. Newman, C. Loland, T. Kopajtic, 2014, Journal of medicinal chemistry.

The use of LeuT as a model in elucidating binding sites for substrates and inhibitors in neurotransmitter transporters.

C. Loland, 2015, Biochimica et biophysica acta.

Grafted biomembranes containing membrane proteins--the case of the leucine transporter.

N. Bovet, C. Loland, T. Pomorski, 2015, Soft matter.

Engineered Zn Switches in the -Aminobutyric Acid (GABA) Transporter-1 DIFFERENTIAL EFFECTS ON GABA UPTAKE AND CURRENTS*

U. Gether, C. Loland, N. MacAulay, 2001 .

Structure-Activity Relationship Studies on a Series of 3α-[Bis(4-fluorophenyl)methoxy]tropanes and 3α-[Bis(4-fluorophenyl)methylamino]tropanes As Novel Atypical Dopamine Transporter (DAT) Inhibitors for the Treatment of Cocaine Use Disorders.

Ara M. Abramyan, Lei Shi, A. Newman, 2017, Journal of medicinal chemistry.

Rhodamine-labeled 2beta-carbomethoxy-3beta-(3,4-dichlorophenyl)tropane analogues as high-affinity fluorescent probes for the dopamine transporter.

S. Rasmussen, A. Newman, U. Gether, 2005, Journal of medicinal chemistry.

R-Modafinil (Armodafinil): A Unique Dopamine Uptake Inhibitor and Potential Medication for Psychostimulant Abuse

Lei Shi, A. Newman, C. Loland, 2012, Biological Psychiatry.

1,3,5-Triazine-Cored Maltoside Amphiphiles for Membrane Protein Extraction and Stabilization.

P. S. Chae, B. Kobilka, B. Byrne, 2019, Journal of the American Chemical Society.

Improving the Sequence Coverage of Integral Membrane Proteins during Hydrogen/Deuterium Exchange Mass Spectrometry Experiments.

P. Man, C. Loland, K. Rand, 2019, Analytical chemistry.

Biodiscoveries within the Australian plant genus Eremophila based on international and interdisciplinary collaboration: results and perspectives on outstanding ethical dilemmas

B. Møller, D. Staerk, C. Loland, 2022, The Plant journal : for cell and molecular biology.

The antidepressant drug vilazodone is an allosteric inhibitor of the serotonin transporter

E. Gouaux, P. Plenge, C. Loland, 2021, Nature Communications.

Short-Range Distance Measurement by Transition Metal Ion FRET.

C. Loland, Jonas S. Mortensen, 2020, Methods in molecular biology.

Structure-Activity Relationships for a series of bis(4-fluorophenyl)methyl)sulfinyl)alkyl alicyclic amines at the dopamine transporter: functionalizing the terminal nitrogen affects affinity, selectivity and metabolic stability.

A. Newman, Alessandro Bonifazi, C. Loland, 2019, Journal of medicinal chemistry.

Substrate-induced conformational dynamics of the dopamine transporter

K. Lindorff-Larsen, S. Rasmussen, Yong Wang, 2019, Nature Communications.

The Isomeric Preference of an Atypical Dopamine Transporter Inhibitor Contributes to Its Selection of the Transporter Conformation.

Ara M. Abramyan, F. Noé, Lei Shi, 2017, ACS chemical neuroscience.

Transition metal ion FRET uncovers K+ regulation of a neurotransmitter/sodium symporter

H. Sitte, Lei Shi, U. Gether, 2016, Nature Communications.

Relationship between Conformational Changes in the Dopamine Transporter and Cocaine-Like Subjective Effects of Uptake Inhibitors

H. Sitte, A. Newman, U. Gether, 2008, Molecular Pharmacology.

An Engineered Lithocholate-Based Facial Amphiphile Stabilizes Membrane Proteins: Assessing the Impact of Detergent Customizability on Protein Stability.

P. S. Chae, B. Kobilka, B. Byrne, 2018, Chemistry.

Novel tripod amphiphiles for membrane protein analysis.

S. Rasmussen, A. Kruse, P. S. Chae, 2013, Chemistry.

Glucose-neopentyl glycol (GNG) amphiphiles for membrane protein study.

S. Rasmussen, A. Kruse, P. S. Chae, 2013, Chemical communications.

Self-assembly behaviors and application of terphenyl-cored trimaltosides for membrane protein study: Impact of detergent hydrophobic group geometry on protein stability.

P. S. Chae, G. Skiniotis, B. Kobilka, 2019, Chemistry.

Elucidating the Mechanism Behind Sodium-Coupled Neurotransmitter Transporters by Reconstitution

U. Gether, C. Loland, Solveig G Schmidt, 2021, Neurochemical Research.

Maltose-bis(hydroxymethyl)phenol (MBPs) and Maltose-tris(hydroxymethyl)phenol (MTPs) Amphiphiles for Membrane Protein Stability.

P. S. Chae, B. Kobilka, B. Byrne, 2021, ACS chemical biology.

Conformationally flexible core-bearing detergents with a hydrophobic or hydrophilic pendant: Effect of pendant polarity on detergent conformation and membrane protein stability.

W. Im, P. S. Chae, S. Gellman, 2021, Acta biomaterialia.

Pendant-bearing glucose-neopentyl glycol (P-GNG) amphiphiles for membrane protein manipulation: Importance of detergent pendant chain for protein stabilization.

P. S. Chae, B. Kobilka, B. Byrne, 2020, Acta biomaterialia.

New Malonate-Derived Tetraglucoside Detergents for Membrane Protein Stability.

P. S. Chae, B. Kobilka, B. Byrne, 2020, ACS chemical biology.

Conformationally restricted monosaccharide-cored glycoside amphiphiles: the effect of detergent head group variation on membrane protein stability.

P. S. Chae, B. Kobilka, Aiman Sadaf, 2019, ACS chemical biology.

Asymmetric maltose neopentyl glycol amphiphiles for a membrane protein study: effect of detergent asymmetricity on protein stability† †Electronic supplementary information (ESI) available. See DOI: 10.1039/c8sc02560f

P. S. Chae, B. Kobilka, K. K. Kumar, 2018, Chemical science.

Steroid‐Based Amphiphiles for Membrane Protein Study: The Importance of Alkyl Spacers for Protein Stability

P. S. Chae, B. Kobilka, B. Byrne, 2018, Chembiochem : a European journal of chemical biology.

Vitamin E-based glycoside amphiphiles for membrane protein structural studies.

P. S. Chae, G. Skiniotis, B. Kobilka, 2018, Organic & biomolecular chemistry.

Dendronic trimaltoside amphiphiles (DTMs) for membrane protein study† †Electronic supplementary information (ESI) available. See DOI: 10.1039/c7sc03700g

P. S. Chae, G. Skiniotis, B. Kobilka, 2017, Chemical science.

New penta-saccharide-bearing tripod amphiphiles for membrane protein structure studies.

P. S. Chae, G. Skiniotis, B. Kobilka, 2017, The Analyst.

Neuropsychiatric disease–associated genetic variants of the dopamine transporter display heterogeneous molecular phenotypes

Thorvald F. Andreassen, U. Gether, C. Loland, 2018, The Journal of Biological Chemistry.

The mechanism of a high-affinity allosteric inhibitor of the serotonin transporter

Ara M. Abramyan, Lei Shi, A. Mørk, 2020, Nature Communications.

Type I and type II positive allosteric modulators of α7 nicotinic acetylcholine receptors induce antidepressant-like activity in mice by a mechanism involving receptor potentiation but not neurotransmitter reuptake inhibition. Correlation with mTOR intracellular pathway activation

H. Arias, C. Loland, A. Michalak, 2021, European Neuropsychopharmacology.

3,4-Bis(hydroxymethyl)hexane-1,6-diol-based maltosides (HDMs) for membrane-protein study: Importance of detergent rigidity-flexibility balance in protein stability.

P. S. Chae, B. Byrne, C. Loland, 2022, Chemistry, an Asian journal.

Glyco‐Steroidal Amphiphiles (GSAs) for Membrane Protein Structural Study

P. S. Chae, B. Kobilka, B. Byrne, 2022, Chembiochem : a European journal of chemical biology.

A new class of amphiphiles bearing rigid hydrophobic groups for solubilization and stabilization of membrane proteins.

S. Rasmussen, A. Kruse, P. S. Chae, 2012, Chemistry.

Self-Assembly Behaviors of a Penta-Phenylene Maltoside and Its Application for Membrane Protein Study.

P. S. Chae, B. Kobilka, B. Byrne, 2019, Chemistry, an Asian journal.

Trehalose-cored amphiphiles for membrane protein stabilization: importance of the detergent micelle size in GPCR stability.

P. S. Chae, B. Kobilka, B. Byrne, 2019, Organic & biomolecular chemistry.

Rationally Engineered Tandem Facial Amphiphiles for Improved Membrane Protein Stabilization Efficacy

P. S. Chae, B. Kobilka, B. Byrne, 2018, Chembiochem : a European journal of chemical biology.

A comparative study of branched and linear mannitol-based amphiphiles on membrane protein stability.

P. S. Chae, B. Kobilka, B. Byrne, 2018, The Analyst.

Conformationally Preorganized Diastereomeric Norbornane-Based Maltosides for Membrane Protein Study: Implications of Detergent Kink for Micellar Properties.

P. S. Chae, G. Skiniotis, B. Kobilka, 2017, Journal of the American Chemical Society.

Butane-1,2,3,4-tetraol-based amphiphilic stereoisomers for membrane protein study: importance of chirality in the linker region† †Electronic supplementary information (ESI) available. See DOI: 10.1039/c6sc02981g Click here for additional data file.

P. S. Chae, B. Kobilka, B. Byrne, 2016, Chemical science.

Accessible Mannitol-Based Amphiphiles (MNAs) for Membrane Protein Solubilisation and Stabilisation.

P. S. Chae, B. Kobilka, Jeffrey Tarrasch, 2016, Chemistry.

Highly Branched Pentasaccharide-Bearing Amphiphiles for Membrane Protein Studies.

P. S. Chae, G. Skiniotis, B. Kobilka, 2016, Journal of the American Chemical Society.

Novel Xylene-Linked Maltoside Amphiphiles (XMAs) for Membrane Protein Stabilisation.

P. S. Chae, B. Kobilka, Kyung Ho Cho, 2015, Chemistry.

Deoxycholate‐Based Glycosides (DCGs) for Membrane Protein Stabilisation

P. S. Chae, B. Byrne, C. Loland, 2015, Chembiochem : a European journal of chemical biology.

Maltose neopentyl glycol-3 (MNG-3) analogues for membrane protein study.

P. S. Chae, Kyung Ho Cho, B. Byrne, 2015, The Analyst.

Neuropeptide Y Y5 receptor antagonism attenuates cocaine-induced effects in mice

A. Fink-Jensen, G. Wörtwein, C. Loland, 2012, Psychopharmacology.

Identification of Intracellular Residues in the Dopamine Transporter Critical for Regulation of Transporter Conformation and Cocaine Binding*

Jonathan A Javitch, Ulrik Gether, J. Javitch, 2004, Journal of Biological Chemistry.

Probing the conformational impact of detergents on the integral membrane protein LeuT by global HDX-MS.

C. Loland, K. Rand, Patrick S Merkle, 2020, Journal of proteomics.

Substrate-modulated unwinding of transmembrane helices in the NSS transporter LeuT

Michel A Cuendet, Kasper D Rand, Kamil Gotfryd, 2018, Science Advances.

Foldable detergents for membrane protein study: Importance of detergent core flexibility in protein stabilization.

W. Im, P. S. Chae, B. Kobilka, 2022, Chemistry.

N-terminal Truncation of the Dopamine Transporter Abolishes Phorbol Ester- and Substance P Receptor-stimulated Phosphorylation without Impairing Transporter Internalization*

J. Javitch, U. Gether, C. Loland, 2003, The Journal of Biological Chemistry.

Novel and High Affinity 2-[(Diphenylmethyl)sulfinyl]acetamide (Modafinil) Analogues as Atypical Dopamine Transporter Inhibitors.

Zheng-Xiong Xi, Alessandro Bonifazi, Rana Rais, 2016, Journal of medicinal chemistry.

Tandem facial amphiphiles for membrane protein stabilization.

R. A. Robbins, L. Miercke, R. Stroud, 2010, Journal of the American Chemical Society.

X-ray structure of LeuT in an inward-facing occluded conformation reveals mechanism of substrate release

Michael V. LeVine, Daniel S. Terry, H. Weinstein, 2020, Nature Communications.

A rhodamine-labeled citalopram analogue as a high-affinity fluorescent probe for the serotonin transporter.

A. Newman, C. Loland, T. N. Jørgensen, 2013, Bioorganic & medicinal chemistry letters.

Pharmacological Characterization of Purified Full-Length Dopamine Transporter from Drosophila melanogaster

Brian T DeVree, C. Loland, S. Schmidt, 2022, Cells.

The binding sites for benztropines and dopamine in the dopamine transporter overlap

H. Weinstein, Lei Shi, A. Newman, 2011, Neuropharmacology.

An Intracellular Interaction Network Regulates Conformational Transitions in the Dopamine Transporter*

Harel Weinstein, Lei Shi, Jonathan A Javitch, 2008, Journal of Biological Chemistry.

Defining Proximity Relationships in the Tertiary Structure of the Dopamine Transporter

U. Gether, C. Loland, U Gether, 1999, The Journal of Biological Chemistry.

Allosteric Modulation of Neurotransmitter Transporters as a Therapeutic Strategy

H. Sitte, T. Stockner, C. Loland, 2020, Trends in pharmacological sciences.

A class of rigid linker-bearing glucosides for membrane protein structural study

P. S. Chae, Aiman Sadaf, B. Byrne, 2015, Chemical science.

Steric Hindrance Mutagenesis in the Conserved Extracellular Vestibule Impedes Allosteric Binding of Antidepressants to the Serotonin Transporter*

H. Weinstein, Lei Shi, A. Newman, 2012, The Journal of Biological Chemistry.

Conformational dynamics of the human serotonin transporter during substrate and drug binding

S. Rasmussen, U. Gether, C. Loland, 2019, Nature Communications.

Exploring the K+ binding site and its coupling to transport in the neurotransmitter:sodium symporter LeuT

J. Mindell, C. Loland, Andreas Nygaard, 2023, bioRxiv.

The mechanism of a high-affinity allosteric inhibitor of the serotonin transporter

Ara M. Abramyan, Lei Shi, A. Mørk, 2020, Nature Communications.

The Environment Shapes the Inner Vestibule of LeuT

Thomas Stockner, Santhosh Kannan Venkatesan, Harald H. Sitte, 2016, PLoS Comput. Biol..

Mesitylene-Cored Glucoside Amphiphiles (MGAs) for Membrane Protein Studies: Importance of Alkyl Chain Density in Detergent Efficacy.

P. S. Chae, B. Kobilka, Kyung Ho Cho, 2016, Chemistry.

Realizing integration in structural biology: The 2022 ISBUC Annual Meeting.

N. Hatzakis, M. Gajhede, B. Kragelund, 2023, Structure.

Persistent binding at dopamine transporters determines sustained psychostimulant effects

H. Sitte, A. Hoffman, C. Lupica, 2023, Proceedings of the National Academy of Sciences of the United States of America.

Mechanism of the Association between Na+ Binding and Conformations at the Intracellular Gate in Neurotransmitter:Sodium Symporters*

George Khelashvili, Jonathan A. Javitch, Harel Weinstein, 2015, The Journal of Biological Chemistry.

SLC6 Neurotransmitter Transporters: Structure, Function, and Regulation

U. Gether, Jacob Andersen, A. Kristensen, 2011, Pharmacological Reviews.

Dynamic extracellular vestibule of human SERT: Unveiling druggable potential with high-affinity allosteric inhibitors.

Ara M. Abramyan, C. Bundgaard, C. Loland, 2023, Proceedings of the National Academy of Sciences of the United States of America.

Tandem malonate-based glucosides (TMGs) for membrane protein structural studies

P. S. Chae, B. Kobilka, B. Byrne, 2017, Scientific Reports.

Resorcinarene-Based Facial Glycosides: Implication of Detergent Flexibility on Membrane-Protein Stability.

P. S. Chae, B. Kobilka, B. Byrne, 2017, Chemistry.

Glucose-neopentyl glycol (GNG) amphiphiles for membrane protein study.

S. Rasmussen, A. Kruse, P. S. Chae, 2013, Chemical communications.

Tris(hydroxymethyl)aminomethane Linker-Bearing Triazine-Based Triglucosides for Solubilization and Stabilization of Membrane Proteins

P. S. Chae, B. Byrne, C. Loland, 2023, Bioconjugate chemistry.

P. S. Chae, B. Kobilka, K. K. Kumar, 2018, Chemical science.

Isomeric Detergent Comparison for Membrane Protein Stability: Importance of Inter‐Alkyl‐Chain Distance and Alkyl Chain Length

P. S. Chae, B. Kobilka, Kyung Ho Cho, 2016, Chembiochem : a European journal of chemical biology.

Tandem neopentyl glycol maltosides (TNMs) for membrane protein stabilisation.

P. S. Chae, B. Kobilka, B. Byrne, 2016, Chemical communications.

Modifications to 1-(4-(2-Bis(4-fluorophenyl)methyl)sulfinyl)alkyl Alicyclic Amines That Improve Metabolic Stability and Retain an Atypical DAT Inhibitor Profile.

A. Newman, C. Loland, R. Rais, 2023, Journal of medicinal chemistry.

Transmembrane transporter proteins: Capturing transport in motion

U. Gether, C. Loland, P. Wellendorph, 2023, Basic & clinical pharmacology & toxicology.

Transition metal ion FRET uncovers K+ regulation of a neurotransmitter/sodium symporter

H. Sitte, Lei Shi, U. Gether, 2016, Nature Communications.