Y. Umesaki

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Induction of Intestinal Th17 Cells by Segmented Filamentous Bacteria

Dan R. Littman, Eoin L. Brodie, Ulas Karaoz, 2009, Cell.

Induction of Colonic Regulatory T Cells by Indigenous Clostridium Species

K. Honda, T. Taniguchi, G. Cheng, 2011, Science.

Differential Roles of Segmented Filamentous Bacteria and Clostridia in Development of the Intestinal Immune System

A. Imaoka, K. Itoh, Y. Umesaki, 1999, Infection and Immunity.

Growth retardation and early death of β‐1, 4‐galactosyltransferase knockout mice with augmented proliferation and abnormal differentiation of epithelial cells

Y. Iwakura, Y. Umesaki, N. Kochibe, 1997, The EMBO journal.

Abrupt induction of GDP-fucose: asialo GM1 fucosyltransferase in the small intestine after conventionalization of germ-free mice.

Y. Umesaki, T. Sakata, T. Yajima, 1982, Biochemical and biophysical research communications.

Segmented Filamentous Bacteria Are Indigenous Intestinal Bacteria That Activate Intraepithelial Lymphocytes and Induce MHC Class II Molecules and Fucosyl Asialo GM1 Glycolipids on the Small Intestinal Epithelial Cells in the Ex‐Germ‐Free Mouse

A. Imaoka, Y. Umesaki, H. Setoyama, 1995, Microbiology and immunology.

Comparison of Bifidobacterium breve strain Yakult transcriptomes in germ-free mice with those in fecal cultures.

T. Shima, Y. Umesaki, Takashi Sato, 2011, Journal of bioscience and bioengineering.

Lactobacillus casei strain Shirota-fermented milk stimulates indigenous Lactobacilli in the pig intestine.

Y. Umesaki, Y. Ohashi, R. Inoue, 2001, Journal of nutritional science and vitaminology.

Structure of the intestinal flora responsible for development of the gut immune system in a rodent model.

Y. Umesaki, H. Setoyama, 2000, Microbes and infection.

Structural and compositional difference in the neutral glycolipids between epithelial and non-epithelial tissue of the mouse small intestine.

Y. Umesaki, K. Takamizawa, M. Ohara, 1989, Biochimica et biophysica acta.

Critical roles of a housekeeping sortase of probiotic Bifidobacterium bifidum in bacterium–host cell crosstalk

Y. Umesaki, N. Okada, M. Serata, 2021, iScience.

Gut-residing segmented filamentous bacteria drive autoimmune arthritis via T helper 17 cells.

Christophe Benoist, C. Benoist, D. Mathis, 2010, Immunity.

Gut Microbiota Drive Autoimmune Arthritis by Promoting Differentiation and Migration of Peyer's Patch T Follicular Helper Cells.

N. Tran, Y. Umesaki, F. Teng, 2016, Immunity.

Differential induction of major histocompatibility complex molecules on mouse intestine by bacterial colonization.

Y. Umesaki, H. Setoyama, S. Matsumoto, 1992, Gastroenterology.

Cytolytic activity of intestinal intraepithelial lymphocytes in germ-free mice is strain dependent and determined by T cells expressing gamma delta T-cell antigen receptors.

Y. Umesaki, T. Shimamura, H. Ishikawa, 1993, Proceedings of the National Academy of Sciences of the United States of America.

Proliferative recruitment of intestinal intraepithelial lymphocytes after microbial colonization of germ‐free mice

A. Imaoka, Y. Umesaki, H. Setoyama, 1996, European journal of immunology.

Prevention of gut inflammation by Bifidobacterium in dextran sulfate-treated gnotobiotic mice associated with Bacteroides strains isolated from ulcerative colitis patients.

H. Ishikawa, A. Imaoka, Y. Umesaki, 2003, Microbes and infection.

Gut Immune Maturation Depends on Colonization with a Host-Specific Microbiota

David A. Relman, Sünje J. Pamp, Christophe Benoist, 2012, Cell.

Improvement of human faecal flora‐associated mouse model for evaluation of the functional foods

A. Imaoka, Y. Umesaki, H. Setoyama, 2004, Journal of applied microbiology.

Inflammatory bowel disease-like enteritis and caecitis in a senescence accelerated mouse P1/Yit strain

A. Imaoka, Y. Umesaki, J. Ohtsuka, 1998, Gut.

Randomized placebo‐controlled trial assessing the effect of bifidobacteria‐fermented milk on active ulcerative colitis

A. Imaoka, Y. Umesaki, Y. Ishii, 2004, Alimentary pharmacology & therapeutics.

Effect of organic acid absorption on bicarbonate transport in rat colon

Y. Umesaki, T. Yokokura, T. Yajima, 1979, Pflügers Archiv.

Beneficial Effects of Probiotic Bifidobacterium and Galacto-Oligosaccharide in Patients with Ulcerative Colitis: A Randomized Controlled Study

H. Ishikawa, A. Imaoka, Y. Umesaki, 2011, Digestion.

Randomized controlled trial of the effect of bifidobacteria-fermented milk on ulcerative colitis.

H. Ishikawa, A. Imaoka, Y. Umesaki, 2000, Journal of the American College of Nutrition.

Gut Bacteria

Y. Benno, T. Hennet, H. Kiyono, 2009, Mucosal Immunology.

Murine Intestinal Bacteria Modulate Antigen-Specific Cytokine Production by Intestinal Immune Cells Derived from Germ-Free TCR-Transgenic Mice

K. Itoh, Y. Umesaki, Kyoko Takahashi, 2008 .

Lymphoid-Tissue-Resident Commensal Bacteria Promote Members of the IL-10 Cytokine Family to Establish Mutualism.

C. Ziegler, Nitin Kumar, H. Kiyono, 2016, Immunity.

Anti-inflammatory activity of probiotic Bifidobacterium: enhancement of IL-10 production in peripheral blood mononuclear cells from ulcerative colitis patients and inhibition of IL-8 secretion in HT-29 cells.

T. Shima, A. Imaoka, Y. Umesaki, 2008, World journal of gastroenterology.

Enteric Bacteria and Their Roles in Inflammatory Bowel Disease

Y. Umesaki, Y. Okabe, N. Watanabe, 1999 .

Appearance of fucolipid after conventionalization of germ-free mice.

Y. Umesaki, K. Tohyama, M. Mutai, 1981, Journal of biochemistry.

Intestinal Bifidobacterium association in germ-free T cell receptor transgenic mice down-regulates dietary antigen-specific immune responses of the small intestine but enhances those of the large intestine.

K. Itoh, Y. Umesaki, Kyoko Takahashi, 2009, Immunobiology.

Transition of the probiotic bacteria, Lactobacillus casei strain Shirota, in the gastrointestinal tract of a pig.

Y. Umesaki, K. Ushida, Y. Ohashi, 2004, International journal of food microbiology.

Altered profiles of intestinal microbiota and organic acids may be the origin of symptoms in irritable bowel syndrome

S. Fukudo, A. Imaoka, Y. Umesaki, 2009, Neurogastroenterology and motility : the official journal of the European Gastrointestinal Motility Society.

Role of microbial fermentation products in irritable bowel syndrome

S. Fukudo, A. Imaoka, Y. Umesaki, 2010, Neurogastroenterology and Motility.

Differential effects of two probiotic strains with different bacteriological properties on intestinal gene expression, with special reference to indigenous bacteria.

T. Shima, A. Imaoka, Y. Umesaki, 2008, FEMS immunology and medical microbiology.

Expansion of αβ T-cell receptor-bearing intestinal intraepithelial lymphocytes after microbial colonization in germ-free mice and its independence from thymus.

Y. Umesaki, H. Setoyama, S. Matsumoto, 1993 .

16S Ribosomal DNA Sequence Divergence of Segmented Filamentous Bacteria with Special Reference to In

A. Imaoka, Y. Umesaki, S. Matsumoto, 1997 .

Effect of Tween 80 on glucosyltransferase production in Streptococcus mutans

Y. Umesaki, M. Mutai, Y. Kawai, 1977, Applied and environmental microbiology.

Immune responses to gut microbiota-commensals and pathogens

K. Honda, T. Tanoue, Y. Umesaki, 2010, Gut microbes.

ATP drives lamina propria TH17 cell differentiation

Masahiro Yamamoto, Junichi Nishimura, Kenya Honda, 2008, Nature.

Pulmonary Th17 Antifungal Immunity Is Regulated by the Gut Microbiome

W. Ouyang, D. Sheppard, K. Bibby, 2016, The Journal of Immunology.

Proinflammatory T-cell responses to gut microbiota promote experimental autoimmune encephalomyelitis

S. Mazmanian, Y. Lee, Y. Umesaki, 2010, Proceedings of the National Academy of Sciences.

Presence of asialo GM1 and glucosylceramide in the intestinal mucosa of mice and induction of fucosyl asialo GM1 by conventionalization of germ-free mice.

Y. Umesaki, A. Suzuki, T. Kasama, 1981, Journal of biochemistry.

Use of gnotobiotic mice to identify and characterize key microbes responsible for the development of the intestinal immune system

Y. Umesaki, 2014, Proceedings of the Japan Academy. Series B, Physical and biological sciences.

Th17 Cell Induction by Adhesion of Microbes to Intestinal Epithelial Cells

M. Hattori, K. Honda, H. Morita, 2015, Cell.

Innate lymphoid cells regulate intestinal epithelial cell glycosylation

B. Becher, M. Sakamoto, Y. Benno, 2014, Science.

Gender bias in autoimmunity is influenced by microbiota.

Aly A. Khan, Laura Graham, D. Antonopoulos, 2013, Immunity.

Microbiotal influence on T cell subset development.

K. Honda, K. Atarashi, Y. Umesaki, 2011, Seminars in immunology.

Complete genome sequences of rat and mouse segmented filamentous bacteria, a potent inducer of th17 cell differentiation.

Vineet K. Sharma, M. Hattori, N. Saitou, 2011, Cell host & microbe.

Regulation of Th17 cell differentiation by intestinal commensal bacteria.

K. Honda, K. Atarashi, T. Tanoue, 2010, Beneficial microbes.

Indigenous opportunistic bacteria inhabit mammalian gut-associated lymphoid tissues and share a mucosal antibody-mediated symbiosis

M. Sakamoto, Y. Benno, C. Sasakawa, 2010, Proceedings of the National Academy of Sciences.

Expansion of alpha beta T-cell receptor-bearing intestinal intraepithelial lymphocytes after microbial colonization in germ-free mice and its independence from thymus.

Y. Umesaki, H. Setoyama, S. Matsumoto, 1993, Immunology.

Interactions between epithelial cells and bacteria, normal and pathogenic.

A. Imaoka, Y. Umesaki, H. Setoyama, 1997, Science.

Factors regulating the expression of the neutral glycolipids in the mouse small intestinal mucosa.

Y. Umesaki, M. Ohara, 1989, Biochimica et biophysica acta.

Rationale for Using of Bifidobacterium Probiotic Strains-Fermented Milk Against Colitis Based on Animal Experiments and Clinical Trials

A. Imaoka, Y. Umesaki, 2009, Probiotics and antimicrobial proteins.

Intracellular offsprings released from SFB filaments are flagellated

P. Sansonetti, I. Guerrera, T. Shima, 2019, Nature Microbiology.

Randomized Controlled Trial of the Effect of Bifidobacteria-Fermented Milk on Ulcerative Colitis

H. Ishikawa, A. Imaoka, Y. Umesaki, 2003, Journal of the American College of Nutrition.

A step‐wise expansion of intestinal intraepithelial T lymphocytes in association with microbial colonization is defined by sensitivity to cyclosporin A

Y. Umesaki, Y. Matsuoka, M. Ohwaki, 1997, Immunology.

Immunohistochemical and biochemical demonstration of the change in glycolipid composition of the intestinal epithelial cell surface in mice in relation to epithelial cell differentiation and bacterial association.

Y. Umesaki, 1984, The journal of histochemistry and cytochemistry : official journal of the Histochemistry Society.

Intestinal Glycolipids and Their Possible Role in Microbial Colonization of Mice

Y. Umesaki, 1989 .

Biosynthesis of microvillus membrane-associated glycoproteins of small intestinal epithelial cells in germ-free and conventionalized mice.

Y. Umesaki, K. Tohyama, M. Mutai, 1982, Journal of biochemistry.

Effects of fecal microorganisms and their chloroform-resistant variants derived from mice, rats, and humans on immunological and physiological characteristics of the intestines of ex-germfree mice

S. Matsumoto, A. Imaoka, Y. Umesaki, 1994, Infection and immunity.

Strain gauge force transducer and its application in a pig model to evaluate the effect of probiotic on colonic motility.

Y. Umesaki, Y. Ohashi, R. Inoue, 2001, Journal of nutritional science and vitaminology.

Localization of asialo GM1 and Forssman antigen in the small intestine of mouse.

Y. Umesaki, A. Suzuki, T. Yamakawa, 1982, Advances in experimental medicine and biology.

Gender bias in autoimmunity is influenced by microbiota.

Aly A. Khan, Laura Graham, D. Antonopoulos, 2013, Immunity.

Cytolytic activity of intestinal intraepithelial lymphocytes in germ-free mice is strain dependent and determined by T cells expressing yv T-cell antigen receptors

Y. Umesaki, T. Shimamura, H. Ishikawa, 2005 .