T. Laha

A. Loukas, P. Brindley, T. Laha, 2014, Infection, genetics and evolution : journal of molecular epidemiology and evolutionary genetics in infectious diseases.

Isolation of cDNAs Encoding Secreted and Transmembrane Proteins from Schistosoma mansoni by a Signal Sequence Trap Method

A. Loukas, D. Smyth, T. Laha, 2003, Infection and Immunity.

Monoclonal Antibodies Targeting an Opisthorchis viverrini Extracellular Vesicle Tetraspanin Protect Hamsters against Challenge Infection

A. Loukas, B. Tedla, P. Brindley, 2021, Vaccines.

Hepatobiliary morbidities detected by ultrasonography in Opisthorchis viverrini-infected patients before and after praziquantel treatment: a five-year follow up study.

A. Loukas, P. Brindley, T. Laha, 2021, Acta tropica.

Reverse transcriptase activity and untranslated region sharing of a new RTE-like, non-long terminal repeat retrotransposon from the human blood fluke, Schistosoma japonicum.

A. Loukas, P. Brindley, T. Laha, 2002, International journal for parasitology.

Knockout of liver fluke granulin, Ov-grn-1, impedes malignant transformation during chronic infection with Opisthorchis viverrini

A. Loukas, P. Brindley, T. Laha, 2022, bioRxiv.

Programmed knockout mutation of liver fluke granulin, Ov-grn-1, attenuates virulence and impedes malignant transformation during chronic opisthorchiasis

A. Loukas, P. Brindley, T. Laha, 2021 .

Granulin Expression in Hamsters during Opisthorchis viverrini Infection-Induced Cholangiocarcinogenesis

P. Brindley, T. Laha, B. Sripa, 2018, Asian Pacific journal of cancer prevention : APJCP.

Phylogenetic relationships within the Opisthorchis viverrini species complex with specific analysis of O. viverrini sensu lato from Sakon Nakhon, Thailand by mitochondrial and nuclear DNA sequencing.

J. Webster, B. Webster, P. Lamberton, 2018, Infection, genetics and evolution : journal of molecular epidemiology and evolutionary genetics in infectious diseases.

Levels of 8-OxodG Predict Hepatobiliary Pathology in Opisthorchis viverrini Endemic Settings in Thailand

C. Pairojkul, P. Brindley, T. Laha, 2015, PLoS neglected tropical diseases.

A Portrait of the Transcriptome of the Neglected Trematode, Fasciola gigantica—Biological and Biotechnological Implications

Ross S Hall, N. Young, A. Jex, 2011, PLoS neglected tropical diseases.

Microsatellite loci in the carcinogenic liver fluke, Opisthorchis viverrini and their application as population genetic markers.

J. Webster, S. Wongkham, S. Klinbunga, 2010, Infection, genetics and evolution : journal of molecular epidemiology and evolutionary genetics in infectious diseases.

Light and electron microscopy observations of embryogenesis and egg development in the human liver fluke, Opisthorchis viverrini (Platyhelminthes, Digenea)

T. Laha, A. Suwannatrai, Malcolm K. Jones, 2011, Parasitology Research.

Secreted cysteine proteases of the carcinogenic liver fluke, Opisthorchis viverrini: regulation of cathepsin F activation by autocatalysis and trans‐processing by cathepsin B

J. Dalton, P. Brindley, T. Laha, 2010, Cellular microbiology.

Cathepsin F Cysteine Protease of the Human Liver Fluke, Opisthorchis viverrini

A. Loukas, J. Dalton, P. Brindley, 2009, PLoS neglected tropical diseases.

Programmed knockout mutation of liver fluke granulin attenuates virulence of infection-induced hepatobiliary morbidity

A. Loukas, N. Young, P. Brindley, 2018, eLife.

Programmed mutation of liver fluke granulin using CRISPR/Cas9 attenuates virulence of infection-induced hepatobiliary morbidity

A. Loukas, N. Young, P. Brindley, 2018, bioRxiv.

Changes in protein expression after treatment with Ancylostoma caninum excretory/secretory products in a mouse model of colitis

A. Loukas, S. Navarro, Ivana Ferreira, 2017, Scientific Reports.

Phylogeography and demographic history of Thai Pediculus humanus capitis (Phthiraptera: Pediculidae) revealed by mitochondrial DNA sequences.

T. Laha, S. Pinlaor, O. Haonon, 2021, Infection, genetics and evolution : journal of molecular epidemiology and evolutionary genetics in infectious diseases.

Impact of geography and time on genetic clusters of Opisthorchis viverrini identified by microsatellite and mitochondrial DNA analysis.

J. Webster, B. Webster, T. Laha, 2020, International journal for parasitology.

Characterization and in vitro functional analysis of thioredoxin glutathione reductase from the liver fluke Opisthorchis viverrini.

T. Laha, P. Saichua, Raynoo Thanan, 2020, Acta tropica.

Functional Analysis of the Unique Cytochrome P450 of the Liver Fluke Opisthorchis felineus

V. Mordvinov, P. Brindley, T. Laha, 2015, PLoS neglected tropical diseases.

Mitochondrial DNA sequence variation among geographical isolates of Opisthorchis viverrini in Thailand and Lao PDR, and phylogenetic relationships with other trematodes

S. Wongkham, T. Laha, M. Barton, 2008, Parasitology.

Schistosome Long Terminal Repeat Retrotransposons

P. Brindley, T. Laha, C. S. Copeland, 2005 .

pido, a non-long terminal repeat retrotransposon of the chicken repeat 1 family from the genome of the Oriental blood fluke, Schistosoma japonicum.

A. Loukas, P. Brindley, T. Laha, 2002, Gene.

The dingo non-long terminal repeat retrotransposons from the genome of the hookworm, Ancylostoma caninum.

A. Loukas, P. Brindley, T. Laha, 2006, Experimental parasitology.

Characterization of SR3 reveals abundance of non-LTR retrotransposons of the RTE clade in the genome of the human blood fluke, Schistosoma mansoni

A. Loukas, P. Brindley, T. Laha, 2005, BMC Genomics.

The fugitive LTR retrotransposon from the genome of the human blood fluke, Schistosoma mansoni.

A. Loukas, P. Brindley, D. Smyth, 2004, International journal for parasitology.

Mobile genetic elements colonizing the genomes of metazoan parasites.

A. Loukas, P. Brindley, T. Laha, 2003, Trends in parasitology.

RNA-Seq Reveals Infection-Induced Gene Expression Changes in the Snail Intermediate Host of the Carcinogenic Liver Fluke, Opisthorchis viverrini

A. Loukas, C. Cantacessi, T. Laha, 2014, PLoS neglected tropical diseases.

Sjalpha elements, short interspersed element-like retroposons bearing a hammerhead ribozyme motif from the genome of the oriental blood fluke Schistosoma japonicum.

A. Loukas, P. Brindley, T. Laha, 2000, Biochimica et biophysica acta.

Progress on the transcriptomics of carcinogenic liver flukes of humans--unique biological and biotechnological prospects.

A. Loukas, N. Young, A. Jex, 2010, Biotechnology advances.

Carcinogenic Parasite Secretes Growth Factor That Accelerates Wound Healing and Potentially Promotes Neoplasia

A. Loukas, C. Whitchurch, J. Golledge, 2015, PLoS pathogens.

Uptake of Schistosoma mansoni extracellular vesicles by human endothelial and monocytic cell lines and impact on vascular endothelial cell gene expression.

Ashley J. Waardenberg, A. Loukas, D. Doolan, 2020, International journal for parasitology.

Special considerations for studies of extracellular vesicles from parasitic helminths: A community‐led roadmap to increase rigour and reproducibility

Chelsea N. Davis, A. Loukas, E. Buzás, 2023, Journal of extracellular vesicles.

Silencing of Opisthorchis viverrini Tetraspanin Gene Expression Results in Reduced Secretion of Extracellular Vesicles

A. Loukas, P. Brindley, T. Laha, 2022, Frontiers in Cellular and Infection Microbiology.

The secreted and surface proteomes of the adult stage of the carcinogenic human liver fluke Opisthorchis viverrini

A. Loukas, P. Brindley, T. Laha, 2010, Proteomics.

A Granulin-Like Growth Factor Secreted by the Carcinogenic Liver Fluke, Opisthorchis viverrini, Promotes Proliferation of Host Cells

Jason Mulvenna, Alex Loukas, Alun Jones, 2009, PLoS pathogens.

Prevalence and intensity of infection with third stage larvae of Angiostrongylus cantonensis in mollusks from Northeast Thailand.

T. Laha, R. Andrews, P. Sithithaworn, 2009, The American journal of tropical medicine and hygiene.

Angiostrongylus cantonensis: experimental study on the susceptibility of apple snails, Pomacea canaliculata compared to Pila polita.

T. Laha, P. Sithithaworn, S. Tesana, 2008, Experimental parasitology.

Hookworm recombinant protein promotes regulatory T cell responses that suppress experimental asthma

A. Loukas, P. Hotez, V. Julia, 2016, Science Translational Medicine.

Suppression of Ov-grn-1 encoding granulin of Opisthorchis viverrini inhibits proliferation of biliary epithelial cells.

A. Loukas, P. Brindley, T. Laha, 2015, Experimental parasitology.

Neglected and Emerging Tropical Diseases in South and Southeast Asia and Northern Australia

P. Leggat, T. Laha, P. Graves, 2018, Tropical medicine and infectious disease.

Toward integrated opisthorchiasis control in northeast Thailand: the Lawa project.

T. Laha, B. Wilcox, B. Sripa, 2015, Acta tropica.

Chicken IgY-based coproantigen capture ELISA for diagnosis of human opisthorchiasis.

P. Brindley, T. Laha, Paul J Brindley, 2017, Parasitology international.

Immunodiagnosis of opisthorchiasis using parasite cathepsin F

P. Brindley, T. Laha, B. Sripa, 2015, Parasitology Research.

The bandit, a New DNA Transposon from a Hookworm—Possible Horizontal Genetic Transfer between Host and Parasite

M. Mitreva, A. Loukas, P. Brindley, 2007, PLoS neglected tropical diseases.

Proteomic profile of Bithynia siamensis goniomphalos snails upon infection with the carcinogenic liver fluke Opisthorchis viverrini.

A. Loukas, C. Cantacessi, T. Laha, 2015, Journal of proteomics.

The tumorigenic liver fluke Opisthorchis viverrini--multiple pathways to cancer.

A. Loukas, P. Brindley, T. Laha, 2012, Trends in parasitology.

Ov-APR-1, an aspartic protease from the carcinogenic liver fluke, Opisthorchis viverrini: functional expression, immunolocalization and subsite specificity.

A. Loukas, S. Wongkham, P. Brindley, 2009, The international journal of biochemistry & cell biology.

Fecal bacterial contamination in natural water reservoirs as an indicator of seasonal infection by Opisthorchis viverrini in snail intermediate hosts.

T. Laha, S. Tesana, B. Sripa, 2012, Parasitology international.

Improvement of PCR for Detection of Opisthorchis viverrini DNA in Human Stool Samples

T. Laha, C. R. Stensvold, K. Iddya, 2007, Journal of Clinical Microbiology.

Genome-wide characterization of microsatellites and marker development in the carcinogenic liver fluke Clonorchis sinensis

P. Brindley, T. Laha, D. Blair, 2015, Parasitology Research.

Analysis of Daily Variation for 3 and for 30 Days of Parasite-Specific IgG in Urine for Diagnosis of Strongyloidiasis by Enzyme-Linked Immunosorbent Assay.

T. Laha, P. Sithithaworn, Sirowan Ruantip, 2021, Acta tropica.

Asparaginyl endopeptidase from the carcinogenic liver fluke, Opisthorchis viverrini, and its potential for serodiagnosis.

A. Loukas, P. Brindley, T. Laha, 2008, International journal of infectious diseases : IJID : official publication of the International Society for Infectious Diseases.

Cloning, expression, and characterization of a novel Opisthorchis viverrini calcium-binding EF-hand protein.

A. Loukas, P. Brindley, T. Laha, 2012, Parasitology international.

Characterization and functional analysis of fatty acid binding protein from the carcinogenic liver fluke, Opisthorchis viverrini.

T. Laha, B. Sripa, Jittiyawadee Sripa, 2017, Parasitology international.

Immunomics-guided discovery of serum and urine antibodies for diagnosing urogenital schistosomiasis: a biomarker identification study

G. G. Mekonnen, S. Knopp, D. Rollinson, 2021, The Lancet. Microbe.

Novel Genes of Opisthorchis viverrini Identified by Immunoscreening with Cholangiocarcinoma Associated Opisthorchiasis Serum

T. Laha, B. Sripa, S. Kaewkes, 2010 .

Advanced periductal fibrosis from infection with the carcinogenic human liver fluke Opisthorchis viverrini correlates with elevated levels of interleukin‐6

Alex Loukas, Jeffrey M. Bethony, Paul J. Brindley, 2009, Hepatology.

Infection with the carcinogenic human liver fluke, Opisthorchis viverrini.

A. Loukas, N. Young, R. Gasser, 2011, Molecular bioSystems.

A cross-sectional study on the potential transmission of the carcinogenic liver fluke Opisthorchis viverrini and other fishborne zoonotic trematodes by aquaculture fish.

T. Laha, R. Andrews, P. Sithithaworn, 2013, Foodborne pathogens and disease.

Effects of aestivation on survival of Bithynia siamensis goniomphalos snails and the infection of Opisthorchis viverrini in the irrigation area of wet- and dry-season rice paddy.

T. Laha, A. Suwannatrai, S. Tesana, 2019, Acta tropica.

Partial protection with a chimeric tetraspanin-leucine aminopeptidase subunit vaccine against Opisthorchis viverrini infection in hamsters.

A. Loukas, P. Brindley, T. Laha, 2020, Acta tropica.

Evidence of a species complex within the food-borne trematode Opisthorchis viverrini and possible co-evolution with their first intermediate hosts

S. Wongkham, T. Laha, N. Chilton, 2007, International journal for parasitology.

Genetic markers for the identification and characterization of Opisthorchis viverrini, a medically important food borne trematode in Southeast Asia

S. Wongkham, T. Laha, R. Andrews, 2006, Acta tropica.

Enzyme markers to identify and characterize Opisthorchis viverrini in Thailand and Lao PDR.

S. Wongkham, T. Laha, N. Chilton, 2006, The Southeast Asian journal of tropical medicine and public health.

Population Genetic Structuring in Opisthorchis viverrini over Various Spatial Scales in Thailand and Lao PDR

J. Webster, S. Klinbunga, T. Laha, 2012, PLoS neglected tropical diseases.

Molecular Changes in Opisthorchis viverrini (Southeast Asian Liver Fluke) during the Transition from the Juvenile to the Adult Stage

Ross S Hall, N. Young, A. Jex, 2012, PLoS neglected tropical diseases.

Elevated Plasma IL-6 Associates with Increased Risk of Advanced Fibrosis and Cholangiocarcinoma in Individuals Infected by Opisthorchis viverrini

A. Loukas, P. Brindley, T. Laha, 2012, PLoS neglected tropical diseases.

Apoptosis of cholangiocytes modulated by thioredoxin of carcinogenic liver fluke.

P. Brindley, T. Laha, G. Rinaldi, 2015, The international journal of biochemistry & cell biology.

Proteomic characterization of the internalization of Opisthorchis viverrini excretory/secretory products in human cells.

A. Loukas, T. Laha, J. Sotillo, 2017, Parasitology international.

Helicobacter pylori GroEL Seropositivity Is Associated with an Increased Risk of Opisthorchis viverrini-Associated Hepatobiliary Abnormalities and Cholangiocarcinoma

T. Laha, P. Saichua, Sutas Suttiprapa, 2021, The Korean journal of parasitology.

Characterization and localization of Opisthorchis viverrini fructose-1,6-bisphosphate aldolase.

T. Laha, T. Senawong, Gulsiri Senawong, 2017, Parasitology international.

Decreased risk of cholangiocarcinogenesis following repeated cycles of Opisthorchis viverrini infection-praziquantel treatment: Magnetic Resonance Imaging (MRI) and histopathological study in a hamster model.

P. Brindley, T. Laha, B. Sripa, 2017, Parasitology international.

Genetic variation at three enzyme loci within a Thailand population of Opisthorchis viverrini

S. Wongkham, T. Laha, N. Chilton, 2008, Parasitology Research.

Epidemiology of strongyloidiasis determined by parasite-specific IgG detections by enzyme-linked immunosorbent assay on urine samples using Strongyloides stercoralis, S. ratti and recombinant protein (NIE) as antigens in Northeast Thailand

T. Laha, J. Bethony, A. Techasen, 2023, PloS one.

Gulliver, a long terminal repeat retrotransposon from the genome of the oriental blood fluke Schistosoma japonicum.

A. Loukas, P. Brindley, T. Laha, 2001, Gene.

Carcinogenic Liver Fluke Secretes Extracellular Vesicles That Promote Cholangiocytes to Adopt a Tumorigenic Phenotype

A. Loukas, C. Whitchurch, L. Turnbull, 2015, The Journal of infectious diseases.

Suppression of mRNAs encoding CD63 family tetraspanins from the carcinogenic liver fluke Opisthorchis viverrini results in distinct tegument phenotypes

A. Loukas, P. Brindley, T. Laha, 2017, Scientific Reports.

Recombinant Opisthorchis viverrini tetraspanin expressed in Pichia pastoris as a potential vaccine candidate for opisthorchiasis

A. Loukas, P. Brindley, T. Laha, 2019, Parasitology Research.

Vaccination of hamsters with Opisthorchis viverrini extracellular vesicles and vesicle-derived recombinant tetraspanins induces antibodies that block vesicle uptake by cholangiocytes and reduce parasite burden after challenge infection

A. Loukas, P. Brindley, T. Laha, 2019, PLoS neglected tropical diseases.

RNA Interference as an Approach to Functional Genomics Genetic Manipulation of Opisthorchis viverrini.

P. Brindley, T. Laha, Sutas Suttiprapa, 2018, Advances in parasitology.

Tetraspanins from Opisthorchis viverrini stimulate cholangiocyte migration and inflammatory cytokine production

A. Loukas, P. Brindley, T. Laha, 2023, bioRxiv.

Data set from the proteomic analysis of Bithynia siamensis goniomphalos snails upon infection with the carcinogenic liver fluke Opisthorchis viverrini

A. Loukas, C. Cantacessi, T. Laha, 2014, Data in brief.

Repeated Ivermectin Treatment Induces Ivermectin Resistance in Strongyloides ratti by Upregulating the Expression of ATP-Binding Cassette Transporter Genes.

T. Laha, S. Pinlaor, P. Sithithaworn, 2021, The American journal of tropical medicine and hygiene.

Small extracellular vesicles but not microvesicles from Opisthorchis viverrini promote cell proliferation in human cholangiocytes

A. Loukas, D. Doolan, P. Brindley, 2023, bioRxiv.

Peptide derived from progranulin of the carcinogenic liver fluke, Opisthorchis viverrini stimulates cell hyperproliferation and proinflammatory cytokine production

A. Loukas, N. Young, P. Brindley, 2023, Research square.

Suppression of aquaporin, a mediator of water channel control in the carcinogenic liver fluke, Opisthorchis viverrini

A. Loukas, P. Brindley, T. Laha, 2014, Parasites & Vectors.

Identification and characterization of protein 14-3-3 in carcinogenic liver fluke Opisthorchis viverrini.

W. Chan-on, T. Laha, Sutas Suttiprapa, 2017, Parasitology international.

Hookworm Excretory/Secretory Products Induce Interleukin-4 (IL-4)+ IL-10+ CD4+ T Cell Responses and Suppress Pathology in a Mouse Model of Colitis

A. Loukas, P. Giacomin, S. Navarro, 2013, Infection and Immunity.

Temperature dependence of Opisthorchis viverrini infection in first intermediate host snail, Bithynia siamensis goniomphalos.

A. Loukas, T. Laha, A. Suwannatrai, 2015, Acta Tropica.

Genome-wide characterization of microsatellites and marker development in the carcinogenic liver fluke Clonorchis sinensis

P. Brindley, T. Laha, D. Blair, 2015, Parasitology Research.

The tumorigenic liver fluke Opisthorchis viverrini--multiple pathways to cancer.

A. Loukas, P. Brindley, T. Laha, 2012, Trends in parasitology.

Secreted and surface proteome and transcriptome of Opisthorchis felineus

A. Loukas, B. Tedla, T. Laha, 2023, Frontiers in Parasitology.

Programmed knockout mutation of liver fluke granulin attenuates virulence of infection-induced hepatobiliary morbidity

A. Loukas, N. Young, P. Brindley, 2019, eLife.

Tetraspanins from the liver fluke Opisthorchis viverrini stimulate cholangiocyte migration and inflammatory cytokine production.

A. Loukas, P. Brindley, T. Laha, 2023, Folia parasitologica.

Suppression of mRNAs encoding CD63 family tetraspanins from the carcinogenic liver fluke Opisthorchis viverrini results in distinct tegument phenotypes

A. Loukas, P. Brindley, T. Laha, 2017, Scientific Reports.

Preliminary genetic evidence of two different populations of Opisthorchis viverrini in Lao PDR

R. Spear, J. Webster, B. Webster, 2017, Parasitology Research.

Recombinant protein production and functional analysis of a M60-like-2 metallopeptidase enzyme from the carcinogenic liver fluke Opisthorchis viverrini

T. Laha, P. Saichua, Sutas Suttiprapa, 2024, Protein Expression and Purification.

Immunodiagnosis of opisthorchiasis using parasite cathepsin F

P. Brindley, T. Laha, B. Sripa, 2015, Parasitology Research.