J. Holmgren

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G. Nair, J. Clemens, S. Shin, 2011, Nature Reviews Gastroenterology &Hepatology.

Evidence for several waves of global transmission in the seventh cholera pandemic

Julian Parkhill, Nicholas J. Croucher, Simon R. Harris, 2011, Nature.

Construction of novel vaccine strains of Vibrio cholerae co-expressing the Inaba and Ogawa serotype antigens.

M. Lebens, J. Holmgren, Stefan L. Karlsson, 2011, Vaccine.

Preparation and evaluation of a freeze-dried oral killed cholera vaccine formulation.

A. Larsson, J. Holmgren, E. Nygren, 2011, European journal of pharmaceutics and biopharmaceutics : official journal of Arbeitsgemeinschaft fur Pharmazeutische Verfahrenstechnik e.V.

Establishment of an Adult Mouse Model for Direct Evaluation of the Efficacy of Vaccines against Vibrio cholerae

J. Holmgren, E. Nygren, B-L Li, 2009, Infection and Immunity.

Vibrio cholerae O139 capsular polysaccharide confers complement resistance in the absence or presence of antibody yet presents a productive target for cell lysis: implications for detection of bactericidal antibodies.

J. Holmgren, S. Attridge, 2009, Microbial pathogenesis.

Differential immunogenicity of Vibrio cholerae O139 variants expressing different combinations of naturally occurring and atypical forms of the serogroup polysaccharide.

J. Holmgren, B-L Li, S. Attridge, 2009, Vaccine.

Cholera Immunity and Cholera Vaccination

J. Clemens, J. Holmgren, 2008 .

Role of antibodies against biotype-specific Vibrio cholerae pili in protection against experimental classical and El Tor cholera

J. Holmgren, J. Osek, G. Jonson, 1994, Infection and immunity.

14 – Cholera Vaccines

G. Nair, F. Qadri, J. Clemens, 2018 .

Phase I Evaluation of Intranasal Trivalent Inactivated Influenza Vaccine with Nontoxigenic Escherichia coli Enterotoxin and Novel Biovector as Mucosal Adjuvants, Using Adult Volunteers

R. Bugarini, J. Holmgren, K. Mills, 2006, Journal of Virology.

Herd immunity conferred by killed oral cholera vaccines in Bangladesh: a reanalysis

D. Sack, M. Yunus, M. Emch, 2005, The Lancet.

Monoclonal Antibodies and Immunodetection Methods for Vibrio cholerae and Escherichia coli Enterotoxins

J. Holmgren, A. Svennerholm, L. Lindholm, 1986 .

Safety and immunogenicity of a reformulated Vietnamese bivalent killed, whole-cell, oral cholera vaccine in adults.

S. Han, J. Clemens, J. Holmgren, 2007, Vaccine.

Oral Cholera Vaccines

J. Kaper, J. Holmgren, 2016 .

CD8– Natural Killer Cells Are Greatly Enriched in the Human Gastrointestinal Tract and Have the Capacity to Respond to Bacteria

L. Öhman, S. Lundin, C. Yun, 2010, Journal of Innate Immunity.

Expression of Cholera Toxin under Non-AKI Conditions in Vibrio cholerae El Tor Induced by Increasing the Exposed Surface of Cultures

T. Buhse, J. Holmgren, G. Soberón-Chávez, 2004, Journal of bacteriology.

Antitoxic immunity in experimental cholera: protection, and serum and local antibody responses in rabbits after enteral and parenteral immunization

J. Holmgren, A. Svennerholm, O. Ouchterlony, 1975, Infection and immunity.

Local Antibody Production in Experimental Pyelonephritis: Amount, Avidity, and Immunoglobulin Class

S. Ahlstedt, J. Holmgren, L. Hanson, 1974, Infection and immunity.

Impaired IFN-γ production after stimulation with bacterial components by natural killer cells from gastric cancer patients.

S. Lundin, C. Yun, J. Holmgren, 2011, Experimental cell research.

A phase I/II study to evaluate safety, tolerability and immunogenicity of Hillchol®, an inactivated single Hikojima strain based oral cholera vaccine, in a sequentially age descending population in Bangladesh.

V. Kanchan, Fatema Khaton, J. Ferdous, 2021, Vaccine.

An Update on Cholera Immunity and Current and Future Cholera Vaccines

J. Holmgren, 2021, Tropical medicine and infectious disease.

When, how, and where can oral cholera vaccines be used to interrupt cholera outbreaks?

J. Clemens, J. Holmgren, 2014, Current topics in microbiology and immunology.

Enteric infections in an endemic area induce a circulating antibody-secreting cell response with homing potentials to both mucosal and systemic tissues.

A. Kantele, F. Qadri, J. Holmgren, 1998, The Journal of infectious diseases.

Immune mechanisms and protective antigens of Vibrio cholerae serogroup O139 as a basis for vaccine development

J. Holmgren, J. Osek, G. Jonson, 1996, Infection and immunity.

Field trial of inactivated oral cholera vaccines in Bangladesh: results from 5 years of follow-up.

D. Sack, J. Chakraborty, J. Clemens, 1996, Vaccine.

Immunity to Vibrio cholerae Infection

J. Holmgren, G. Jonson, A. Svennerholm, 1994 .

Immunological memory after immunization with oral cholera B subunit--whole-cell vaccine in Swedish volunteers.

J. Holmgren, A. Svennerholm, M. Jertborn, 1994, Vaccine.

Immunity to enterotoxin-producing bacteria

J. Holmgren, A. Svennerholm, 1992 .

Identification of a mannose-binding pilus on Vibrio cholerae El Tor.

J. Holmgren, A. Svennerholm, G. Jonson, 1991, Microbial pathogenesis.

Biotype as determinant of natural immunising effect of cholera

D. Sack, J. Harris, J. Chakraborty, 1991, The Lancet.

New vaccines against bacterial enteric infections.

J. Holmgren, A. Svennerholm, 1990, Scandinavian journal of infectious diseases. Supplementum.

Adoptive transfer of gut mucosal antitoxin memory by isolated B cells 1 year after oral immunization with cholera toxin

J. Holmgren, N. Lycke, 1989, Infection and immunity.

Oral immunization against cholera.

D. Sack, J. Clemens, J. Holmgren, 1989, Current topics in microbiology and immunology.

Long‐Term Cholera Antitoxin Memory in the Gut can be Triggered to Antibody Formation Associated with Protection within Hours of an Oral Challenge Immunization

J. Holmgren, N. Lycke, 1987, Scandinavian journal of immunology.

Strong biotype and serotype cross-protective antibacterial and antitoxic immunity in rabbits after cholera infection.

J. Holmgren, A. Svennerholm, N. Lycke, 1986, Microbial pathogenesis.

Vaccine development for the control of cholera and related toxin-induced diarrhoeal diseases.

J. Holmgren, A. Svennerholm, 1985, Ciba Foundation symposium.

Secretory Immunity to Vibrio Cholerae Bacteria and Cholera Toxin: Prospects for an Improved Cholera Vaccine

D. Sack, J. Holmgren, A. Svennerholm, 1985 .

Seroepidemiological studies of El Tor cholera in Bangladesh: association of serum antibody levels with protection.

R. Glass, J. Holmgren, A. Svennerholm, 1985, The Journal of infectious diseases.

Mucosal antitoxic and antibacterial immunity after cholera disease and after immunization with a combined B subunit-whole cell vaccine.

D. Sack, J. Holmgren, A. Svennerholm, 1984, The Journal of infectious diseases.

Protection against cholera in breast-fed children by antibodies in breast milk.

B. Stoll, R. Glass, J. Holmgren, 1983, The New England journal of medicine.

A cholera toxoid-insulin conjugate as an oral vaccine against spontaneous autoimmune diabetes.

J. Petersen, C. Czerkinsky, J. Holmgren, 1997, Proceedings of the National Academy of Sciences of the United States of America.

Strong adjuvant properties of cholera toxin on gut mucosal immune responses to orally presented antigens.

J. Holmgren, N. Lycke, 1986, Immunology.

Development of improved cholera vaccine based on subunit toxoid

J. Holmgren, A. Svennerholm, H. Lundbeck, 1977, Nature.

Mechanisms of disease and immunity in cholera: a review.

J. Holmgren, A. Svennerholm, 1977, The Journal of infectious diseases.

Cholera toxin, ganglioside receptors and the immune response.

J. Holmgren, L. Lindholm, 1976, Immunological communications.

Cholera toxin and the adenylate cyclase-activating signal.

J. Holmgren, I. Lönnroth, 1976, The Journal of infectious diseases.

Protein reagent modification of cholera toxin: characterization of effects on antigenic, receptor-binding and toxic properties.

J. Holmgren, I. Lönnroth, 1975, Journal of general microbiology.

Oligomeric structure of cholera toxin: characteristics of the H and L subunits.

J. Holmgren, I. Lonnroth, 1975, Journal of general microbiology.

Mechanism of action of cholera toxin. Specific inhibition of toxin‐induced activation of adenylate cyclase

J. Holmgren, I. Lönnroth, 1975, FEBS Letters.

Subunit structure of cholera toxin.

J. Holmgren, I. Lönnroth, 1973, Journal of general microbiology.

Modern History of Cholera Vaccines and the Pivotal Role of icddr,b

J. Holmgren, 2021, The Journal of infectious diseases.

Polystyrene-adsorbed gangliosides for investigation of the structure of the tetanus-toxin receptor.

H. Elwing, J. Holmgren, L. Svennerholm, 1980, European journal of biochemistry.

Transient entry of enterotoxin subunits into the periplasm occurs during their secretion from Vibrio cholerae

J. Holmgren, T. Hirst, 1987, Journal of bacteriology.

oral cholera vaccine. with toxin in vitamin A-deficient rats immunized Impaired mucosal antibody response to cholera

J. Holmgren, L. Hanson, U. Wiedermann, 2013 .

Impaired mucosal antibody response to cholera toxin in vitamin A-deficient rats immunized with oral cholera vaccine

U. Dahlgren, H. Kahu, J. Holmgren, 1993, Infection and immunity.

Virulence factors, pathogenesis and vaccine protection in cholera and ETEC diarrhea.

J. Holmgren, Joaquín Sánchez, 2005, Current opinion in immunology.

Dendritic cell vaccination protects mice against lethality caused by genital herpes simplex virus type 2 infection.

J. Holmgren, A. Harandi, K. Eriksson, 2001, Journal of reproductive immunology.

Sublingual Tolerance Induction with Antigen Conjugated to Cholera Toxin B Subunit Induces Foxp3+CD25+CD4+ Regulatory T Cells and Suppresses Delayed‐Type Hypersensitivity Reactions

C. Czerkinsky, J. Holmgren, M. Blomquist, 2006, Scandinavian journal of immunology.

Expression of the Escherichia coli lamB gene in Vibrio cholerae.

A. Harkki, J. Holmgren, T. Hirst, 1986, Microbial pathogenesis.

Biodegradable microparticles for oral immunization.

D. Rahman, J. Holmgren, K. Mills, 1993, Vaccine.

18 – Diarrhea Caused by Bacteria

J. Holmgren, A. Lundgren, 2018 .

Synthesis of a precursor to the B subunit of heat-labile enterotoxin in Escherichia coli

J. Holmgren, T. Hirst, E. T. Palva, 1981, Journal of bacteriology.

Ultrastructural localization of cell membrane GM1 ganglioside by cholera toxin.

H. Hansson, J. Holmgren, L. Svennerholm, 1977, Proceedings of the National Academy of Sciences of the United States of America.

Role of local IgA antitoxin-producing cells for intestinal protection against cholera toxin challenge.

J. Holmgren, N. Lycke, A. Bromander, 1989, International archives of allergy and applied immunology.

Intestinal immune responses in humans. Oral cholera vaccination induces strong intestinal antibody responses and interferon-gamma production and evokes local immunological memory.

C. Czerkinsky, J. Holmgren, L. Hanson, 1991, The Journal of clinical investigation.

Induction of compartmentalized B-cell responses in human tonsils

C. Czerkinsky, J. Holmgren, G. Granström, 1995, Infection and immunity.

Differential expression of intestinal membrane transporters in cholera patients

Carl-Fredrik Flach, F. Qadri, J. Holmgren, 2007, FEBS letters.

Retrospective Analysis of Serotype Switching of Vibrio cholerae O1 in a Cholera Endemic Region Shows It Is a Non-random Process

G. Dougan, N. Thomson, A. Mutreja, 2016, PLoS neglected tropical diseases.

Recent advances in mucosal vaccines and adjuvants.

J. Holmgren, K. Eriksson, 2002, Current opinion in immunology.

in primary IgA nephropathy

M. Daha, J. Holmgren, J. W. Fijter, 1996 .

Deficient IgA1 immune response to nasal cholera toxin subunit B in primary IgA nephropathy.

J. D. de Fijter, M. Daha, J. Holmgren, 1996, Kidney international.

Alpha-galactosylceramide enhances mucosal immunity to oral whole-cell cholera vaccines

M. Lebens, J. Holmgren, Craig P. McEntee, 2019, Mucosal Immunology.

A truncated form of HpaA is a promising antigen for use in a vaccine against Helicobacter pylori.

Carl-Fredrik Flach, J. Holmgren, M. Blomquist, 2011, Vaccine.

Chapter 42 – Mucosal Immunity to Bacteria

J. Holmgren, A. Svennerholm, 2005 .

A paper disc technique for studying antibacterial synergism.

J. Holmgren, O. Möller, 2009, Acta pathologica et microbiologica Scandinavica.

Immunohistological detection of fucosyl-GM1 ganglioside in human lung cancer and normal tissues with monoclonal antibodies.

J. Bergh, O. Nilsson, J. Holmgren, 1989, Cancer research.

Adjuvants Enhance the Induction of Germinal Center and Antibody Secreting Cells in Spleen and Their Persistence in Bone Marrow of Neonatal Mice

I. Jónsdóttir, J. Holmgren, A. Harandi, 2019, Front. Immunol..

Receptor-like glycocompounds in human milk that inhibit classical and El Tor Vibrio cholerae cell adherence (hemagglutination)

J. Holmgren, A. Svennerholm, M. Lindblad, 1983, Infection and immunity.

Sialosyllactotetraosylceramide, a novel ganglioside antigen detected in human carcinomas by a monoclonal antibody

O. Nilsson, J. Holmgren, L. Lindholm, 1985, FEBS letters.

Chemical structure of carcinoma ganglioside antigens defined by monoclonal antibody C-50 and some allied gangliosides of human pancreatic adenocarcinoma.

J. Holmgren, L. Lindholm, J. Månsson, 1985, Biochimica et biophysica acta.

Comparison of the Tissue Receptors for Vibrio cholerae and Escherichia coli Enterotoxins by Means of Gangliosides and Natural Cholera Toxoid

J. Holmgren, 1973, Infection and immunity.

Fixation and inactivation of cholera toxin by GM1 ganglioside.

J. Holmgren, L. Svennerholm, I. Lönnroth, 1973, Scandinavian journal of infectious diseases.

Comparison oftheTissue Receptors forVibrio cholerae andEscherichia coli Enterotoxins by Means ofGangliosides andNatural Cholera Toxoid

J. Holmgren, 1973 .

Nasal Administration of Schistosoma mansoni Egg Antigen‐Cholera B Subunit Conjugate Suppresses Hepatic Granuloma Formation and Reduces Mortality in S. mansoni‐Infected Mice

N. Mielcarek, C. Czerkinsky, J. Holmgren, 2001, Scandinavian journal of immunology.

Infection of vaginal and colonic epithelial cells by the human immunodeficiency virus type 1 is neutralized by antibodies raised against conserved epitopes in the envelope glycoprotein gp120.

C. Czerkinsky, J. Holmgren, B. Svennerholm, 1994, Proceedings of the National Academy of Sciences of the United States of America.

Cost of immunization with a locally produced, oral cholera vaccine in Viet Nam.

J. Clemens, J. Holmgren, D. D. Trach, 2001, Vaccine.

Intranasal Immunization of Mice with Group B Streptococcal Protein Rib and Cholera Toxin B Subunit Confers Protection against Lethal Infection

G. Lindahl, J. Holmgren, C. Larsson, 2004, Infection and Immunity.

Immune responses against oxidized LDL as possible targets for prevention of atherosclerosis in systemic lupus erythematosus.

A. Bengtsson, M. Lebens, J. Holmgren, 2021, Vascular pharmacology.

Cholera Toxin B Subunit as a Carrier Molecule Promotes Antigen Presentation and Increases CD40 and CD86 Expression on Antigen-Presenting Cells

M. Lebens, J. Holmgren, K. Eriksson, 2001, Infection and Immunity.

Oral Tolerance Induction with Antigen Conjugated to Cholera Toxin B Subunit Generates Both Foxp3+CD25+ and Foxp3−CD25− CD4+ Regulatory T Cells1

S. Lundin, J. Holmgren, S. Raghavan, 2006, The Journal of Immunology.

Correlates of protection for enteric vaccines.

U. Parashar, J. Holmgren, S. Plotkin, 2017, Vaccine.

Incidence of enteric infections caused by different pathogens in children below 5 years of age ( GEMS study data adapted from Kotloff

C. Czerkinsky, J. Holmgren, 2015 .

Structural basis for differential receptor binding of cholera and Escherichia coli heat‐labile toxins: influence of heterologous amino acid substitutions in the cholera B‐subunit

M. Bäckström, M. Lebens, S. Teneberg, 1997, Molecular microbiology.

Evaluation of different immunization schedules for oral cholera B subunit-whole cell vaccine in Swedish volunteers.

J. Holmgren, A. Svennerholm, M. Jertborn, 1993, Vaccine.

Detection of a ganglioside antigen associated with small cell lung carcinomas using monoclonal antibodies directed against fucosyl-GM1.

O. Nilsson, J. Holmgren, L. Lindholm, 1986, Cancer research.

Induction and assessment of immunity at enteromucosal surfaces in humans: implications for vaccine development.

C. Czerkinsky, J. Holmgren, A. Svennerholm, 1993, Clinical infectious diseases : an official publication of the Infectious Diseases Society of America.

Cholera Toxin Induces a Transient Depletion of CD8+ Intraepithelial Lymphocytes in the Rat Small Intestine as Detected by Microarray and Immunohistochemistry

Carl-Fredrik Flach, J. Holmgren, E. Jennische, 2005, Infection and Immunity.

B Lymphocytes Promote Expansion of Regulatory T Cells in Oral Tolerance: Powerful Induction by Antigen Coupled to Cholera Toxin B Subunit1

Carl-Fredrik Flach, C. Czerkinsky, J. Holmgren, 2008, The Journal of Immunology.

Cholera Toxin B Subunit Powerful Induction by Antigen Coupled to Regulatory T Cells in Oral Tolerance : B Lymphocytes Promote Expansion of

Carl-Fredrik Flach, C. Czerkinsky, J. Holmgren, 2008 .

Sublingual ‘Oral Tolerance’ Induction with Antigen Conjugated to Cholera Toxin B Subunit Generates Regulatory T Cells that Induce Apoptosis and Depletion of Effector T Cells

C. Czerkinsky, J. Holmgren, J. Sun, 2007, Scandinavian journal of immunology.

B Lymphocytes Treated In Vitro with Antigen Coupled to Cholera Toxin B Subunit Induce Antigen-Specific Foxp3+ Regulatory T Cells and Protect against Experimental Autoimmune Encephalomyelitis

C. Czerkinsky, J. Holmgren, Jia-bin Sun, 2012, The Journal of Immunology.

The adjuvant effect of Vibrio cholerae and Escherichia coli heat‐labile enterotoxins is linked to their ADP‐ribosyltransferase activity

J. Holmgren, N. Lycke, T. Tsuji, 1992, European journal of immunology.

An oral B subunit: whole cell vaccine against cholera.

D. Sack, J. Clemens, J. Holmgren, 1992, Vaccine.

Cholera Toxin Enhances Alloantigen Presentation by Cultured Intestinal Epithelial Cells

J. Holmgren, N. Lycke, A. Bromander, 1993, Scandinavian journal of immunology.

Cholera toxin stimulates IL-1 production and enhances antigen presentation by macrophages in vitro.

J. Holmgren, N. Lycke, A. Bromander, 1991, Journal of immunology.

Ten years of the Global Alliance for Vaccines and Immunization: challenges and progress

S. Kaufmann, A. Mantovani, J. Clemens, 2010, Nature Immunology.

A Double Mutant Heat-Labile Toxin from Escherichia coli, LT(R192G/L211A), Is an Effective Mucosal Adjuvant for Vaccination against Helicobacter pylori Infection

Carl-Fredrik Flach, J. Holmgren, J. Clements, 2013, Infection and Immunity.

Mucosal adjuvants based on cholera toxin and E . coli heat-labile enterotoxin

C. Czerkinsky, M. Lebens, J. Holmgren, 2006 .

Effect of pre-existing immunity for systemic and mucosal immune responses to intranasal immunization with group B Streptococcus type III capsular polysaccharide-cholera toxin B subunit conjugate.

J. Holmgren, G. Wallerström, Y. Yang, 2001, Vaccine.

Group B Streptococcus Capsular Polysaccharide-Cholera Toxin B Subunit Conjugate Vaccines Prepared by Different Methods for Intranasal Immunization

J. Holmgren, Yonghong Yang, T. Lagergård, 2001, Infection and Immunity.

Preparation and preclinical evaluation of experimental group B streptococcus type III polysaccharide-cholera toxin B subunit conjugate vaccine for intranasal immunization.

J. Holmgren, Y. Yang, T. Lagergård, 2000, Vaccine.

Systemic and Mucosal Immune Responses in Mice after Mucosal Immunization with Group B Streptococcus Type III Capsular Polysaccharide-Cholera Toxin B Subunit Conjugate Vaccine

J. Holmgren, Yonghong Yang, T. Lagergård, 2000, Infection and Immunity.

Differential Kinetics and Distribution of Antibodies in Serum and Nasal and Vaginal Secretions after Nasal and Oral Vaccination of Humans

J. Holmgren, A. Rudin, E. Johansson, 1998, Infection and Immunity.

Intranasal vaccination of humans with recombinant cholera toxin B subunit induces systemic and local antibody responses in the upper respiratory tract and the vagina

J. Holmgren, A. Rudin, T. Lagergård, 1997, Infection and immunity.

Genital Antibody Responses in Mice after Intranasal Infection with an Attenuated Candidate Vector Strain ofBordetella pertussis

C. Locht, N. Mielcarek, F. Menozzi, 2000, Infection and Immunity.

Specific-Antibody-Secreting Cells in the Rectums and Genital Tracts of Nonhuman Primates following Vaccination

C. Czerkinsky, J. Holmgren, J. Osek, 1998, Infection and Immunity.

Natural Killer Cells and Helicobacter pylori Infection: Bacterial Antigens and Interleukin-12 Act Synergistically To Induce Gamma Interferon Production

C. Yun, J. Holmgren, A. Svennerholm, 2005, Infection and Immunity.

Cholera as a model for research on mucosal immunity and development of oral vaccines.

C. Czerkinsky, J. Holmgren, 1992 .

Gangliosides as receptors for bacterial toxins and Sendai virus.

H. Elwing, J. Holmgren, L. Svennerholm, 1980, Advances in experimental medicine and biology.

Efficacy and safety of a modified killed-whole-cell oral cholera vaccine in India: an interim analysis of a cluster-randomised, double-blind, placebo-controlled trial

Allan Donner, Anna Lena Lopez, Jan Holmgren, 2009, The Lancet.

Vibriocidal Antibody Responses to a Bivalent Killed Whole-Cell Oral Cholera Vaccine in a Phase III Trial in Kolkata, India

G. Nair, J. Clemens, T. Mahapatra, 2014, PloS one.

Anti-bacterial and anti-toxic immunity induced by a killed whole-cell-cholera toxin B subunit cholera vaccine is essential for protection against lethal bacterial infection in mouse pulmonary cholera model

C. Czerkinsky, C. Yun, J. Holmgren, 2012, Mucosal Immunology.

A Randomized, Placebo-Controlled Trial of the Bivalent Killed, Whole-Cell, Oral Cholera Vaccine in Adults and Children in a Cholera Endemic Area in Kolkata, India

S. Han, J. Clemens, D. Sur, 2008, PloS one.

Efficacy of a Low-Cost, Inactivated Whole-Cell Oral Cholera Vaccine: Results from 3 Years of Follow-Up of a Randomized, Controlled Trial

Allan Donner, Anna Lena Lopez, Jan Holmgren, 2011, PLoS neglected tropical diseases.

Evaluating improved inactivated oral cholera vaccines for use in ending endemic cholera by 2030: opportunities and challenges.

J. Clemens, J. Holmgren, J. Deen, 2022, The Lancet. Infectious diseases.

Vaccines against enteric infections for the developing world

C. Czerkinsky, J. Holmgren, 2015, Philosophical Transactions of the Royal Society B: Biological Sciences.

5 year efficacy of a bivalent killed whole-cell oral cholera vaccine in Kolkata, India: a cluster-randomised, double-blind, placebo-controlled trial.

Allan Donner, Anna Lena Lopez, Thomas F Wierzba, 2013, The Lancet. Infectious diseases.

A case for control of cholera in Africa by vaccination.

J. Holmgren, 2012, The Lancet. Infectious diseases.

An oral alpha-galactosylceramide adjuvanted Helicobacter pylori vaccine induces protective IL-1R- and IL-17R-dependent Th1 responses

J. Holmgren, Craig P. McEntee, E. Lavelle, 2019, npj Vaccines.

Coupling of antigen to cholera toxin for dendritic cell vaccination promotes the induction of MHC class I‐restricted cytotoxic T cells and the rejection of a cognate antigen‐expressing model tumor

J. Holmgren, K. Eriksson, M. Fredriksson, 2004, European journal of immunology.

Relative significance of mannose-sensitive hemagglutinin and toxin-coregulated pili in colonization of infant mice by Vibrio cholerae El Tor

J. Holmgren, S. Attridge, P. Manning, 1996, Infection and immunity.

Cloning and sequencing of Vibrio cholerae mannose‐sensitive haemagglutinin pilin gene: localization of mshA within a cluster of type 4 pilin genes

M. Lebens, J. Holmgren, G. Jonson, 1994, Molecular microbiology.

Anticarrier immunity suppresses the antibody response to polysaccharide antigens after intranasal immunization with the polysaccharide-protein conjugate

J. Holmgren, T. Lagergård, C. Bergquist, 1997, Infection and immunity.

A Novel Nonantibiotic, lgt-Based Selection System for Stable Maintenance of Expression Vectors in Escherichia coli and Vibrio cholerae

M. Lebens, J. Holmgren, Susanne Källgård, 2017, Applied and Environmental Microbiology.

Mucosal and systemic antibody responses after peroral or intranasal immunization: Effects of conjugation to enterotoxin B subunits and/or of co‐administration with free toxin as adjuvant

C. Czerkinsky, J. Holmgren, M. Fredriksson, 2000, APMIS : acta pathologica, microbiologica, et immunologica Scandinavica.

Cholera toxin B subunit (CTB) entrapped in microparticles shows comparable immunogenicity to CTB mixed with whole cholera toxin following oral immunization

J. Holmgren, J. P. McGee, M. Lindblad, 1995 .

Characterization of precipitating antibodies to E. coli O antigen in infants and children with acute pyelonephritis.

J. Holmgren, B. Kaijser, U. Jodal, 1971, Clinical and experimental immunology.

Oral administration of cholera toxin B-insulin conjugates protects NOD mice from autoimmune diabetes by inducing CD4+ regulatory T-cells.

C. Czerkinsky, J. Holmgren, C. Thivolet, 1999, Diabetes.

Surface expression of Helicobacter pylori HpaA adhesion antigen on Vibrio cholerae, enhanced by co-expressed enterotoxigenic Escherichia coli fimbrial antigens.

S. Wai, M. Lebens, J. Holmgren, 2017, Microbial pathogenesis.

Treatment of experimental autoimmune arthritis by nasal administration of a type II collagen-cholera toxoid conjugate vaccine.

R. Holmdahl, C. Czerkinsky, J. Holmgren, 1999, Arthritis and rheumatism.

Intranasal administration of a Schistosoma mansoni glutathione S-transferase-cholera toxoid conjugate vaccine evokes antiparasitic and antipathological immunity in mice.

A. Capron, N. Mielcarek, C. Czerkinsky, 1999, Journal of immunology.

Oral tolerance and anti-pathological vaccines.

C. Czerkinsky, J. Holmgren, J. Sun, 1999, Current topics in microbiology and immunology.

Differential effect of cholera toxin on CD45RA+ and CD45RO+ T cells: specific inhibition of cytokine production but not proliferation of human naive T cells

C. Czerkinsky, J. Holmgren, K. Eriksson, 2000, Clinical and experimental immunology.

Vaccination with Bordetella pertussis-Pulsed Autologous or Heterologous Dendritic Cells Induces a Mucosal Antibody Response In Vivo and Protects against Infection

N. Mielcarek, J. Holmgren, K. Eriksson, 2001, Infection and Immunity.

Mucosal adjuvants and anti-infection and anti-immunopathology vaccines based on cholera toxin, cholera toxin B subunit and CpG DNA.

T. Lehner, Carl-Fredrik Flach, C. Czerkinsky, 2005, Immunology letters.

Mucosal immunisation and adjuvants: a brief overview of recent advances and challenges.

C. Czerkinsky, J. Holmgren, K. Eriksson, 2003, Vaccine.

B cells treated with CTB-p210 acquire a regulatory phenotype in vitro and reduce atherosclerosis in apolipoprotein E deficient mice.

M. Lebens, J. Holmgren, H. Björkbacka, 2018, Vascular pharmacology.

Immunopathogenesis and prevention of uveitis with the Behçet's disease-specific peptide linked to cholera toxin B.

T. Lehner, J. Holmgren, T. Shinnick, 2003, Advances in experimental medicine and biology.

Autoimmune Encephalomyelitis T Cells and Protect against Experimental Regulatory + Induce Antigen-Specific Foxp3 Antigen Coupled to Cholera Toxin B Subunit B Lymphocytes Treated In Vitro with

C. Czerkinsky, J. Holmgren, Jia-Bin Sun, 2012 .

Cholera Toxin and Its B Subunit Promote Dendritic Cell Vaccination with Different Influences on Th1 and Th2 Development

J. Holmgren, K. Eriksson, M. Fredriksson, 2003, Infection and Immunity.

Transcutaneous Immunization with Cholera Toxin B Subunit Adjuvant Suppresses IgE Antibody Responses Via Selective Induction of Th1 Immune Responses 1

C. Czerkinsky, J. Holmgren, F. Anjuère, 2003, The Journal of Immunology.

Intestinal and systemic immune responses in humans after oral immunization with a bivalent B subunit-O1/O139 whole cell cholera vaccine.

J. Holmgren, A. Svennerholm, M. Jertborn, 1996, Vaccine.

Intestinal antibody response after oral immunization with a prototype cholera B subunit-colonization factor antigen enterotoxigenic Escherichia coli vaccine.

C. Wennerås, J. Holmgren, A. Svennerholm, 1993, Vaccine.

Safety and immunogenicity of an oral recombinant cholera B subunit-whole cell vaccine in Swedish volunteers.

J. Holmgren, A. Svennerholm, M. Jertborn, 1992, Vaccine.

Effects of undernutrition on infection with Vibrio cholerae O1 and on response to oral cholera vaccine.

B. Stoll, R. Glass, J. Holmgren, 1989, The Pediatric infectious disease journal.

Five-year immunologic memory in Swedish volunteers after oral cholera vaccination.

J. Holmgren, A. Svennerholm, M. Jertborn, 1988, The Journal of infectious diseases.

Saliva, breast milk, and serum antibody responses as indirect measures of intestinal immunity after oral cholera vaccination or natural disease

J. Holmgren, A. Svennerholm, M. Jertborn, 1986, Journal of clinical microbiology.

Effect of neutralization of gastric acid on immune responses to an oral B subunit, killed whole-cell cholera vaccine.

D. Sack, J. Clemens, J. Holmgren, 1986, The Journal of infectious diseases.

Treatment of experimental autoimmune encephalomyelitis by feeding myelin basic protein conjugated to cholera toxin B subunit.

T. Olsson, C. Czerkinsky, J. Holmgren, 1996, Proceedings of the National Academy of Sciences of the United States of America.

Circulating Cholera Antitoxin Memory Cells in the Blood One Year after Oral Cholera Vaccination in Humans

J. Holmgren, N. Lycke, U. Hellström, 1987, Scandinavian journal of immunology.

Intestinal Mucosal Memory and Presence of Memory Cells in Lamina Propria and Peyer's Patches in Mice 2 Years after Oral Immunization with Cholera Toxin

J. Holmgren, N. Lycke, 1986, Scandinavian journal of immunology.

Cholera antibody production in vitro by peripheral blood lymphocytes following oral immunization of humans and mice.

J. Holmgren, L. Lindholm, N. Lycke, 1985, Clinical and experimental immunology.

Rabbit intestinal glycoprotein receptor for Escherichia coli heat-labile enterotoxin lacking affinity for cholera toxin

J. Holmgren, A. Svennerholm, L. Svennerholm, 1982, Infection and immunity.

INTESTINAL ANTIBODY RESPONSES AFTER IMMUNISATION WITH CHOLERA B SUBUNIT

D. Sack, J. Holmgren, P. Bardhan, 1982, The Lancet.

INTERACTION OF CHOLERA TOXIN AND TOXIN DERIVATIVES WITH LYMPHOCYTES

J. Holmgren, L. Lindholm, I. Lönnroth, 1974, The Journal of experimental medicine.

Safety and immunogenicity of an oral inactivated enterotoxigenic Escherichia coli vaccine.

J. Holmgren, A. Svennerholm, C. Åhrén, 1998, Vaccine.

Construction and preclinical evaluation of mmCT, a novel mutant cholera toxin adjuvant that can be efficiently produced in genetically manipulated Vibrio cholerae.

M. Lebens, J. Holmgren, Stefan L. Karlsson, 2016, Vaccine.

Antibody Responses in the Lower Respiratory Tract and Male Urogenital Tract in Humans after Nasal and Oral Vaccination with Cholera Toxin B Subunit

J. Holmgren, A. Rudin, G. Riise, 1999, Infection and Immunity.

Use of chlorpromazine in the treatment of cholera and other severe acute watery diarrheal diseases

D. Sack, M. Islam, J. Holmgren, 1982 .

The use of chlorpromazine in the treatment of cholera and other severe acute watery diarrheal diseases.

D. Sack, M. Islam, J. Holmgren, 1982, Gastroenterology.

Enzyme-Linked Immunosorbent Assays for Cholera Serology

J. Holmgren, A. Svennerholm, 1973, Infection and immunity.

Monoclonal antibodies raised against NeuAc alpha 2-6neolactotetraosylceramide detect carcinoma-associated gangliosides.

O. Nilsson, J. Holmgren, L. Lindholm, 1985, Biochimica et biophysica acta.

Local and systemic antibody responses and immunological memory in humans after immunization with cholera B subunit by different routes.

D. Sack, J. Holmgren, P. Bardhan, 1984, Bulletin of the World Health Organization.

Robust gut associated vaccine-specific antibody-secreting cell responses are detected at the mucosal surface of Bangladeshi subjects after immunization with an oral killed bivalent V. cholerae O1/O139 whole cell cholera vaccine: comparison with other mucosal and systemic responses.

D. Sack, R. Sack, F. Qadri, 2009, Vaccine.

Oral vaccines against cholera and enterotoxigenic Escherichia coli diarrhea.

J. Holmgren, A. Svennerholm, 1995, Advances in experimental medicine and biology.

Recombinant system for overexpression of cholera toxin B subunit in Vibrio cholerae as a basis for vaccine development.

J. Holmgren, J. Sánchez, 1989, Proceedings of the National Academy of Sciences of the United States of America.

Receptor-specific large-scale purification of cholera toxin on silica beads derivatized with lysoGM1 ganglioside.

J. Holmgren, L. Svennerholm, J. Tayot, 1981, European journal of biochemistry.

Tissue receptor for cholera exotoxin: structural requirements of G11 ganglioside in toxin binding and inactivation.

J. Holmgren, J. Månsson, L. Svennerholm, 1974, Medical biology.

Recombinant fusion protein for simple detection of Escherichia coli heat-stable enterotoxin by GM1 enzyme-linked immunosorbent assay

J. Holmgren, A. Svennerholm, J. Sánchez, 1990, Journal of clinical microbiology.

Purification of El Tor cholera enterotoxins and comparisons with classical toxin.

J. Holmgren, R. Dubey, M. Lindblad, 1990, Journal of general microbiology.

Recombinant cholera toxin B subunit and gene fusion proteins for oral vaccination.

J. Holmgren, A. Svennerholm, B. Löwenadler, 1990, Research in microbiology.

Monoclonal antibodies against Escherichia coli heat-stable toxin (STa) and their use in a diagnostic ST ganglioside GM1-enzyme-linked immunosorbent assay

J. Holmgren, A. Svennerholm, M. Wikström, 1986, Journal of clinical microbiology.

Alteration of the antibody response to Escherichia coli O antigen in mice by prior exposure to various somatic antigens.

S. Ahlstedt, J. Holmgren, 1975, Immunology.

An antigenic relationship between kidney and certain Escherichia coli strains.

J. Holmgren, L. Hanson, S. Holm, 1971, International Archives of Allergy and Applied Immunology.

Immunodiffusion studies on Escherichia coli. 1. Identification of O, K and H antigens in an O6 strain.

J. Holmgren, K. Lincoln, L. Hanson, 2009, Acta pathologica et microbiologica Scandinavica.

Sendai virus receptor: proposed recognition structure based on binding to plastic-adsorbed gangliosides.

H. Elwing, J. Holmgren, L. Svennerholm, 1980, Proceedings of the National Academy of Sciences of the United States of America.

Synthesis in Vibrio cholerae and secretion of hepatitis B virus antigens fused to Escherichia coli heat-labile enterotoxin subunit B.

H. Will, J. Holmgren, J. Sánchez, 1991, Gene.

Experimental Studies on Cholera Immunization II. Evidence for Protective Antitoxic Immunity Mediated by Serum Antibodies as Well as Local Antibodies

J. Holmgren, A. Andersson, Ö. Ouchterlony, 1972, Infection and immunity.

Current status and future prospects for a vaccine against schistosomiasis

C. Czerkinsky, M. Lebens, J. Holmgren, 2004, Expert review of vaccines.

Effect of protein release rates from tablet formulations on the immune response after sublingual immunization.

A. Larsson, J. Holmgren, A. Ekman, 2012, European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences.

In vivo modulation of intracellular cAMP and cell growth of a lymphatic tumour in mice by cholera toxin.

J. Holmgren, L. Lindholm, C. Lönnroth, 1977, Experimental cell research.

Cellular basis of immunomodulation by cholera toxin in vitro with possible association to the adjuvant function in vivo.

J. Holmgren, N. Lycke, L. Ekman, 1989, Journal of immunology.

Detoxification of Cholera Toxin without Removal of Its Immunoadjuvanticity by the Addition of (STa-related) Peptides to the Catalytic Subunit

J. Holmgren, G. Wallerström, Joaquín Sánchez, 2002, The Journal of Biological Chemistry.

CA-50 as a tumour marker for monitoring colorectal cancer: antigen rises in patients postoperatively precede clinical manifestations of recurrence.

L. Påhlman, J. Holmgren, B. Glimelius, 1988, European journal of cancer & clinical oncology.

Serum levels of the carcinoma-associated antigen CA 50 in ulcerative colitis.

J. Holmgren, L. Lindholm, B. Persson, 1987, Scandinavian journal of gastroenterology.

Detection by monoclonal antibody of carbohydrate antigen CA 50 in serum of patients with carcinoma.

O. Nilsson, C. Rudenstam, J. Holmgren, 1984, British medical journal.

Murine antibody responses following systemic or mucosal immunization with viable or inactivated Vibrio cholerae.

J. Holmgren, E. Nygren, S. Attridge, 2008, Vaccine.

Requirement for Cyclic AMP/Protein Kinase A-Dependent Canonical NFκB Signaling in the Adjuvant Action of Cholera Toxin and Its Non-toxic Derivative mmCT

M. Lebens, J. Holmgren, Maximilian Larena, 2019, Front. Immunol..

Cholera Toxin, and the Related Nontoxic Adjuvants mmCT and dmLT, Promote Human Th17 Responses via Cyclic AMP–Protein Kinase A and Inflammasome-Dependent IL-1 Signaling

M. Lebens, J. Holmgren, A. Lundgren, 2015, The Journal of Immunology.

Inflammasome-Dependent IL-1 Signaling Protein Kinase A and - Human Th17 Responses via Cyclic AMP Adjuvants mmCT and dmLT, Promote Cholera Toxin, and the Related Nontoxic

M. Lebens, J. Holmgren, A. Lundgren, 2015 .

Oral administration of a streptococcal antigen coupled to cholera toxin B subunit evokes strong antibody responses in salivary glands and extramucosal tissues

C. Czerkinsky, J. Holmgren, M. Russell, 1989, Infection and immunity.

CD11chigh Dendritic Cells Are Essential for Activation of CD4+ T Cells and Generation of Specific Antibodies following Mucosal Immunization1

U. Yrlid, J. Holmgren, M. Blomquist, 2009, The Journal of Immunology.

CD11c Dendritic Cells Are Essential for Activation of CD4 T Cells and Generation of Specific Antibodies following Mucosal Immunization

U. Yrlid, J. Holmgren, M. Blomquist, 2009 .

Fucosyl-GM1 — A ganglioside associated with small cell lung carcinomas

O. Nilsson, J. Holmgren, L. Lindholm, 1984, Glycoconjugate Journal.

Binding specificity of monoclonal antibodies to ganglioside, Fuc-GM1.

O. Nilsson, J. Holmgren, L. Lindholm, 1986, Biochimica et biophysica acta.

A novel adjuvanted capsule based strategy for oral vaccination against infectious diarrhoeal pathogens.

J. Holmgren, Craig P. McEntee, E. Lavelle, 2016, Journal of controlled release : official journal of the Controlled Release Society.

Clinical trial to evaluate safety and immunogenicity of an oral inactivated enterotoxigenic Escherichia coli prototype vaccine containing CFA/I overexpressing bacteria and recombinantly produced LTB/CTB hybrid protein.

R. Walker, J. Holmgren, A. Svennerholm, 2013, Vaccine.

Construction of a non-toxigenic Escherichia coli oral vaccine strain expressing large amounts of CS6 and inducing strong intestinal and serum anti-CS6 antibody responses in mice.

M. Lebens, J. Holmgren, A. Svennerholm, 2011, Vaccine.

Over-expression of major colonization factors of enterotoxigenic Escherichia coli, alone or together, on non-toxigenic E. coli bacteria.

M. Lebens, J. Holmgren, E. Nygren, 2010, Vaccine.

Construction and expression of immunogenic hybrid enterotoxigenic Escherichia coli CFA/I and CS2 colonization fimbriae for use in vaccines

M. Lebens, J. Holmgren, A. Svennerholm, 2010, Applied Microbiology and Biotechnology.

Sublingual immunization induces broad-based systemic and mucosal immune responses in mice.

C. Czerkinsky, J. Holmgren, P. Hofman, 2007, Vaccine.

Development of oral vaccines against enterotoxinogenic Escherichia coli diarrhoea.

D. Sack, J. Holmgren, A. Svennerholm, 1989, Vaccine.

Interaction of Bordetella pertussis with mast cells, modulation of cytokine secretion by pertussis toxin

C. Locht, N. Mielcarek, B. Johansson, 2001, Cellular microbiology.

High frequency of spontaneous interferon‐gamma‐producing cells in human tonsils: role of local accessory cells and soluble factors

C. Czerkinsky, J. Holmgren, B. Ferruà, 1993, Clinical and experimental immunology.

Local and systemic antibody responses to dextran-cholera toxin B subunit conjugates

J. Holmgren, T. Lagergård, M. Lindblad, 1995, Infection and immunity.

The validity of the ammonium sulphate precipitation technique of estimation of antibody amount and avidity.

S. Ahlstedt, J. Holmgren, L. Hanson, 1973, Immunology.

Immunological characterization of a rotavirus-neutralizing epitope fused to the cholera toxin B subunit.

J. Holmgren, C. Arias, S. López, 1993, Gene.

"PERFEXT": a direct method for quantitative assessment of cytokine production in vivo at the local level.

C. Czerkinsky, J. Holmgren, H. Carol, 1997, Research in immunology.

Thermolysin treatment; an improved dispersion technique for isolating functional lymphoid cells from intestinal tissues

C. Czerkinsky, J. Holmgren, A. Kilander, 1990 .

Expansion of gamma-interferon producing cell populations in the intestinal mucosa after peroral immunisation in humans

C. Czerkinsky, J. Holmgren, A. Kilander, 1990 .

Enhanced immunological tolerance against allograft rejection by oral administration of allogeneic antigen linked to cholera toxin B subunit.

C. Czerkinsky, J. Holmgren, J. Sun, 2000, Clinical immunology.

Oral administration of cholera toxin B subunit conjugated to myelin basic protein protects against experimental autoimmune encephalomyelitis by inducing transforming growth factor-beta-secreting cells and suppressing chemokine expression.

C. Czerkinsky, J. Holmgren, H. Link, 2000, International immunology.

Cholera Toxin B Subunit as Transmucosal Carrier‐Delivery and Immunomodulating System for Induction of Antiinfectious and Antipathological Immunity a

C. Czerkinsky, M. Lebens, J. Holmgren, 1996, Annals of the New York Academy of Sciences.

Mucosal adjuvants and anti-infection and anti-immunopathology vaccines based on cholera toxin, cholera toxin B subunit and CpG DNA

C. Czerkinsky, J. Holmgren, A. Harandi, 2003, Expert review of vaccines.

Antibody-producing cells in peripheral blood and salivary glands after oral cholera vaccination of humans

R. Jonsson, C. Czerkinsky, J. Holmgren, 1991, Infection and immunity.

Synthesis of hybrid molecules between heat-labile enterotoxin and cholera toxin B subunits: potential for use in a broad-spectrum vaccine

M. Bäckström, M. Lebens, J. Holmgren, 1996, Infection and immunity.

Safety and immunogenicity of an improved oral inactivated multivalent enterotoxigenic Escherichia coli (ETEC) vaccine administered alone and together with dmLT adjuvant in a double-blind, randomized, placebo-controlled Phase I study.

M. Petzold, J. Holmgren, A. Svennerholm, 2014, Vaccine.

An oral B subunit-whole cell vaccine against cholera: from concept to successful field trial.

D. Sack, R. Black, J. Clemens, 1987, Advances in experimental medicine and biology.

Synergistic protective effect in rabbits of immunization with Vibrio cholerae lipopolysaccharide and toxin/toxoid

J. Holmgren, A. Svennerholm, 1976, Infection and immunity.

Large-Scale Production of Vibrio cholerae Toxin B Subunit for Use in Oral Vaccines

M. Lebens, J. Holmgren, J. Osek, 1993, Bio/Technology.

Prolonged oral treatment with low doses of allergen conjugated to cholera toxin B subunit suppresses immunoglobulin E antibody responses in sensitized mice

C. Czerkinsky, J. Holmgren, M. Fredriksson, 2000 .

Mucosal vaccination increases local chemokine production attracting immune cells to the stomach mucosa of Helicobacter pylori infected mice.

Carl-Fredrik Flach, J. Holmgren, S. Raghavan, 2012, Vaccine.

Suppressive versus stimulatory effects of allergen/cholera toxoid (CTB) conjugates depending on the nature of the allergen in a murine model of type I allergy.

J. Holmgren, C. Ebner, B. Jahn-Schmid, 1999, International immunology.

Development of an Oral Vaccine Against Enterotoxigenic Escherichia coli Diarrhea

C. Wennerås, J. Holmgren, A. Svennerholm, 1991 .

Roles of different coli surface antigens of colonization factor antigen II in colonization by and protective immunogenicity of enterotoxigenic Escherichia coli in rabbits

C. Wennerås, J. Holmgren, A. Svennerholm, 1990, Infection and immunity.

Genetic fusion of a non‐toxic heat‐stable enterotoxin‐related decapeptide antigen to cholera toxin B‐subunit

J. Holmgren, A. Svennerholm, A. Svennerholm, 1988, FEBS letters.

Synthesis on nontoxic, antibody-binding Escherichia coli heat-stable enterotoxin (STa) peptides

J. Holmgren, A. Svennerholm, B. Svennerholm, 1988 .

Prevention of mucosally induced uveitis with a HSP60‐derived peptide linked to cholera toxin B subunit

T. Lehner, J. Holmgren, T. Shinnick, 2003, European journal of immunology.

Immunological cross-reactivity betweenEscherichia coli heat-labile enterotoxin and cholera toxin A and B subunits

J. Holmgren, A. Svennerholm, 2007, Current Microbiology.

Differential roles of B cells and IFN-gamma-secreting CD4(+) T cells in innate and adaptive immune control of genital herpes simplex virus type 2 infection in mice.

J. Holmgren, B. Svennerholm, A. Harandi, 2001, The Journal of general virology.

The subcellular location of antigen expressed by adenoviral vectors modifies adaptive immunity but not dependency on cross‐presenting dendritic cells

Carl-Fredrik Flach, U. Yrlid, J. Holmgren, 2011, European journal of immunology.

Cholera toxin B subunit: an efficient transmucosal carrier-delivery system for induction of peripheral immunological tolerance.

C. Czerkinsky, J. Holmgren, J. Sun, 1994, Proceedings of the National Academy of Sciences of the United States of America.

Enterotoxin-producing bacteria and parasites in stools of Ethiopian children with diarrhoeal disease.

J. Holmgren, R. Möllby, G. Meeuwisse, 1976, Archives of disease in childhood.

Diminished immunopathology in Schistosoma mansoni infection following intranasal administration of cholera toxin B‐immunodominant peptide conjugate correlates with enhanced transforming growth factor‐β production by CD4 T cells

M. Lebens, J. Holmgren, M. Stadecker, 2002, Parasite immunology.

Vibrio cholerae expresses cell surface antigens during intestinal infection which are not expressed during in vitro culture

J. Holmgren, A. Svennerholm, G. Jonson, 1989, Infection and immunity.

Influences on Th 1 and Th 2 Development Dendritic Cell Vaccination with Different Cholera Toxin and Its B Subunit Promote

J. Holmgren, K. Eriksson, M. Fredriksson, 2003 .

Nonimmunoglobulin fraction of human milk inhibits bacterial adhesion (hemagglutination) and enterotoxin binding of Escherichia coli and Vibrio cholerae

J. Holmgren, A. Svennerholm, C. Åhrén, 1981, Infection and immunity.

Antibody responses to live and killed poliovirus vaccines in the milk of Pakistani and Swedish women.

J. Holmgren, A. Svennerholm, B. Svennerholm, 1981, The Journal of infectious diseases.

Protection against Vibrio cholerae El Tor infection by specific antibodies against mannose-binding hemagglutinin pili

J. Holmgren, A. Svennerholm, J. Osek, 1992, Infection and immunity.

Development of oral vaccines against cholera and enterotoxinogenic Escherichia coli diarrhea.

J. Holmgren, A. Svennerholm, 1990, Scandinavian journal of infectious diseases. Supplementum.

Different secretory immunoglobulin A antibody responses to cholera vaccination in Swedish and Pakistani women

J. Holmgren, A. Svennerholm, L. Hanson, 1980, Infection and immunity.

Induction of protective immunity by vaccination against Chlamydia trachomatis using the major outer membrane protein adjuvanted with CpG oligodeoxynucleotide coupled to the nontoxic B subunit of cholera toxin.

J. Holmgren, A. Harandi, Chun-mei Cheng, 2009, Vaccine.

Immunoglobulin Class Avidity, and Pyelonephritis: Amount, in Experimental Local Antibody Production

S. Ahlstedt, J. Holmgren, L. Hanson, 2013 .

Identification ofEscherichia coli heat-labile enterotoxin by means of a ganglioside immunosorbent assay (GM1-ELISA) procedure

J. Holmgren, A. Svennerholm, 2007, Current Microbiology.

Evaluation of a ganglioside immunosorbent assay for detection of Escherichia coli heat-labile enterotoxin

J. Holmgren, A. Svennerholm, R. Möllby, 1979, Journal of clinical microbiology.

Evaluation ofa Ganglioside Immunosorbent Assayfor Detection ofEscherichia coli Heat-Labile Enterotoxin

J. Holmgren, A. Svennerholm, R. Mollby, 1979 .

ELISA for the Study of Enterotoxic Diarrhoeal Diseases

J. Holmgren, A. Svennerholm, J. Holmgren, 1978 .

A Protective Role of Locally Administered Immunostimulatory CpG Oligodeoxynucleotide in a Mouse Model of Genital Herpes Infection

J. Holmgren, A. Harandi, K. Eriksson, 2003, Journal of Virology.

Interleukin-12 (IL-12) and IL-18 Are Important in Innate Defense against Genital Herpes Simplex Virus Type 2 Infection in Mice but Are Not Required for the Development of Acquired Gamma Interferon-Mediated Protective Immunity

J. Holmgren, B. Svennerholm, A. Harandi, 2001, Journal of Virology.

Comparison of receptors for cholera and Escherichia coli enterotoxins in human intestine.

J. Holmgren, L. Svennerholm, P. Fredman, 1985, Gastroenterology.

In Vivo Adjuvant-Induced Mobilization and Maturation of Gut Dendritic Cells after Oral Administration of Cholera Toxin1

C. Czerkinsky, M. Lebens, J. Holmgren, 2004, The Journal of Immunology.

Genetic fusion of human insulin B‐chain to the B‐subunit of cholera toxin enhances in vitro antigen presentation and induction of bystander suppression in vivo

J. Petersen, M. Lebens, J. Holmgren, 2002, Immunology.

Mucosal Immunity in the Gastrointestinal Tract in Relation to ETEC Vaccine Development

J. Holmgren, A. Svennerholm, Y. López-Vidal, 1989 .

Role of PCF8775 antigen and its coli surface subcomponents for colonization, disease, and protective immunogenicity of enterotoxigenic Escherichia coli in rabbits

J. Holmgren, A. Svennerholm, B. Rowe, 1988, Infection and immunity.

Local and systemic antibody responses to naturally acquired enterotoxigenic Escherichia coli diarrhea in an endemic area.

B. Stoll, D. Barua, J. Holmgren, 1986, The Journal of infectious diseases.

Important Role for FcγRIIB on B Lymphocytes for Mucosal Antigen-Induced Tolerance and Foxp3+ Regulatory T Cells

Kenneth G. C. Smith, Z. Xiang, J. Holmgren, 2013, The Journal of Immunology.

Important Role for FcγRIIB on B Lymphocytes for Mucosal Antigen-Induced Tolerance and Foxp3+ Regulatory T Cells

Kenneth G. C. Smith, Z. Xiang, J. Holmgren, 2013, The Journal of Immunology.

Development of vaccines and drugs against diarrhea : 11th Nobel Conference, Stockholm, 1985

J. Holmgren, R. Möllby, A. Lindberg, 1986 .

Immunodiffusion studies on Escherichia coli. 2. Characterization of antigens used for passive haemagglutination with an O 6 strain as model.

J. Holmgren, L. Hanson, 2009, Acta pathologica et microbiologica Scandinavica.

Conformation of protein secreted across bacterial outer membranes: a study of enterotoxin translocation from Vibrio cholerae.

J. Holmgren, T. Hirst, 1987, Proceedings of the National Academy of Sciences of the United States of America.

Cholera Toxin: Assembly, Secretion and in Vivo Expression

J. Holmgren, A. Svennerholm, T. Hirst, 1991 .

Mechanism of toxin secretion by Vibrio cholerae investigated in strains harboring plasmids that encode heat-labile enterotoxins of Escherichia coli.

J. Kaper, J. Holmgren, T. Hirst, 1984, Proceedings of the National Academy of Sciences of the United States of America.

Chapter 48 – Enteric Bacterial Vaccines: Salmonella, Shigella, Vibrio cholerae, Escherichia coli

M. Levine, J. Nataro, J. Holmgren, 2005 .

Protective Vaccination Against Genital Herpes Simplex Virus Type 2 (HSV‐2) Infection in Mice is Associated with a Rapid Induction of Local IFN‐γ‐Dependent RANTES Production Following a Vaginal Viral Challenge

J. Holmgren, B. Svennerholm, A. Harandi, 2001, American journal of reproductive immunology.

Consensus Meeting on International Standards for Oral Whole Cell Killed Cholera Vaccines, 17-18 May 2018, Seoul, Republic of Korea

F. Qadri, J. Holmgren, J. Lynch, 2019, Vaccination Research – Open Journal.

Vaccines Against Diarrheal Diseases

J. Holmgren, A. Svennerholm, 1999 .

A recombinant Escherichia coli heat-stable enterotoxin (STa) fusion protein eliciting anti-STa neutralizing antibodies.

E. Holmgren, A. Elmblad, J. Holmgren, 1991, FEMS microbiology letters.

Vaccination with dendritic cells pulsed in vitro with tumor antigen conjugated to cholera toxin efficiently induces specific tumoricidal CD8+ cytotoxic lymphocytes dependent on cyclic AMP activation of dendritic cells.

J. Holmgren, K. Eriksson, M. Lindblad, 2004, Clinical immunology.

Enterotoxin-Specific Immunoglobulin E Responses in Humans after Infection or Vaccination with Diarrhea-Causing Enteropathogens

M. Asaduzzaman, C. Wennerås, D. Sack, 2000, Infection and Immunity.

Quantitation of vibriocidal antibodies using agar plague techniques.

J. Holmgren, A. Svennerholm, O. Ouchterlony, 1971, Acta pathologica et microbiologica Scandinavica. Section B: Microbiology and immunology.

Antibodies in human serum and milk induced by enterobacteria and food proteins.

S. Ahlstedt, J. Holmgren, L. Hanson, 2008, Ciba Foundation symposium.

Structure and arrangement of the cholera toxin genes in Vibrio cholerae O139.

M. Lebens, J. Holmgren, 1994, FEMS microbiology letters.

Mucosal immunity and vaccines

Jan Holmgren, C. Czerkinsky, J. Holmgren, 2005, Nature Medicine.

Characterization of enterotoxin and soluble hemagglutinin from Vibrio mimicus: identity with V. cholerae O1 toxin and hemagglutinin

H. Dotevall, J. Holmgren, S. Sanyal, 1985 .

Multiple attacks of hepatitis in drug addicts: biochemical, immunochemical, and morphologic characteristics.

P. Lundin, J. Holmgren, S. Iwarson, 1973, The Journal of infectious diseases.

CD4+CD25+ suppressor T cells regulate pathogen induced inflammation and disease.

J. Holmgren, S. Raghavan, 2005, FEMS immunology and medical microbiology.

Actions of cholera toxin and the prevention and treatment of cholera

J. Holmgren, 1981, Nature.

Novel Carbohydrate Binding Site Recognizing Blood Group A and B Determinants in a Hybrid of Cholera Toxin and Escherichia coli Heat-labile Enterotoxin B-subunits*

N. Karlsson, M. Bäckström, M. Lebens, 2000, The Journal of Biological Chemistry.

Structural studies of the Vibrio cholerae O-antigen.

J. Holmgren, B. Lindberg, T. Holme, 1979, Carbohydrate research.

Monoclonal antibodies against gastrointestinal tumour-associated antigens isolated as monosialogangliosides.

O. Nilsson, J. Holmgren, L. Lindholm, 1983, International archives of allergy and applied immunology.

Sensitization and development of tolerance via the gut

U. Dahlgren, E. Telemo, C. Czerkinsky, 1993, Pediatric allergy and immunology : official publication of the European Society of Pediatric Allergy and Immunology.

Interaction of cholera toxin and membrane GM1 ganglioside of small intestine.

J. Holmgren, J. Månsson, L. Svennerholm, 1975, Proceedings of the National Academy of Sciences of the United States of America.

Tumor‐cell killing by MAbs against fucosyl GM1, a ganglioside antigen associated with small‐cell lung carcinoma

J. Holmgren, L. Lindholm, F. Brezicka, 1991, International journal of cancer.

Mouse monoclonal antibodies for experimental immunotherapy promotes killing of tumor cells

L. Larson, J. Holmgren, L. Lindholm, 1988, International journal of cancer.

Boosting of Secretory IgA Antibody Responses in Man by Parenteral Cholera Vaccination

J. Holmgren, A. Svennerholm, L. Hanson, 1977, Scandinavian journal of immunology.

Tissue Receptor for Cholera Exotoxin: Postulated Structure from Studies with GM1 Ganglioside and Related Glycolipids

J. Holmgren, L. Svennerholm, L Svennerholm, 1973, Infection and immunity.

Immunoglobulin and specific-antibody synthesis in vitro by enteral and nonenteral lymphoid tissues after subcutaneous cholera immunization

J. Holmgren, A. Svennerholm, 1977 .

Protective capacity of antibodies against E. coli O antigen with special reference to the avidity.

S. Ahlstedt, J. Holmgren, L. Hanson, 1974, International archives of allergy and applied immunology.

The primary and secondary antibody response to Escherichia coli O6 lipopolysaccharide analysed at the humoral and cellular level. Amount and avidity of the antibodies in relation to protective capacity.

S. Ahlstedt, J. Holmgren, L. Hanson, 1973, Immunology.

Reversal of cyclic AMP-mediated intestinal secretion in mice by chlorpromazine.

J. Holmgren, I. Lönnroth, S. Lange, 1978, Gastroenterology.

Lymphoid cell populations dynamics and the mucosal immune response in humans

C. Czerkinsky, J. Holmgren, A. Svennerholm, 1990 .

Bacterial enteric infections and vaccine development.

J. Holmgren, A. Svennerholm, 1992, Gastroenterology clinics of North America.

Predisposition for cholera of individuals with O blood group. Possible evolutionary significance.

B. Stoll, R. Glass, R. Black, 1985, American journal of epidemiology.

Alpha-galactosylceramide enhances mucosal immunity to oral whole-cell cholera vaccines

M. Lebens, J. Holmgren, Craig P. McEntee, 2019, Mucosal Immunology.

Mucosal delivery routes for optimal immunization: targeting immunity to the right tissues.

C. Czerkinsky, J. Holmgren, 2012, Current topics in microbiology and immunology.

Intestinal and circulating antibody‐forming cells in IgA‐deficient individuals after oral cholera vaccination

D. Ericson, C. Czerkinsky, J. Holmgren, 1994, Clinical and experimental immunology.

The Binding of Bacteria Carrying CFAs and Putative CFAs to Rabbit Intestinal Brush Border Membranes

C. Wennerås, J. Holmgren, A. Svennerholm, 1991 .

Cholera and Oral-Mucosal Anti-infectious and Anti-inflammatory Vaccines

C. Czerkinsky, M. Lebens, J. Holmgren, 1996 .

B‐Cell Activation in Duodenal Mucosa after Oral Cholera Vaccination in IgA Deficient Subjects with or without IgG Subclass Deficiency

J. Holmgren, P. Brandtzaeg, L. Hanson, 1993, Scandinavian journal of immunology.

Swedish Agency for Research Cooperation with Developing Countries. Prospects for public health benefits in developing countries from new vaccines against enteric infections.

D. Sack, J. Holmgren, L. Freij, 1991, The Journal of infectious diseases.

Field trial of oral cholera vaccines in Bangladesh: results from three-year follow-up

Yunus, D. Sack, J. Harris, 1990, The Lancet.

IMPACT OF B SUBUNIT KILLED WHOLE-CELL AND KILLED WHOLE-CELL-ONLY ORAL VACCINES AGAINST CHOLERA UPON TREATED DIARRHOEAL ILLNESS AND MORTALITY IN AN AREA ENDEMIC FOR CHOLERA

D. Sack, J. Chakraborty, J. Clemens, 1988, The Lancet.

Protective efficacy in humans of killed whole-vibrio oral cholera vaccine with and without the B subunit of cholera toxin

M. Levine, R. Black, J. Holmgren, 1987, Infection and immunity.

FIELD TRIAL OF ORAL CHOLERA VACCINES IN BANGLADESH

D. Sack, J. Chakraborty, J. Holmgren, 1986, The Lancet.

A randomized, controlled trial of the toxin-blocking effects of B subunit in family members of patients with cholera.

R. Glass, J. Holmgren, M. R. Khan, 1984, The Journal of infectious diseases.

Cholera and the immune response.

J. Holmgren, A. Svennerholm, 1983, Progress in allergy.

Virus‐specific antibody production and polyclonal B‐cell activation in the intestinal mucosa of HIV‐infected individuals

G. Norkrans, L. Hagberg, C. Czerkinsky, 1995, AIDS.

Topical immunization strategies

C. Czerkinsky, J. Holmgren, Jan Holmgren, 2010, Mucosal Immunology.

Thermostability of the coating, antigen and immunostimulator in an adjuvanted oral capsule vaccine formulation.

J. Holmgren, E. Lavelle, M. Rosa, 2017, International journal of pharmaceutics.

IgA isotype restriction in the mucosal but not in the extramucosal immune response after oral immunizations with cholera toxin or cholera B subunit.

J. Holmgren, L. Lindholm, N. Lycke, 1983, International archives of allergy and applied immunology.

Lack of Fc Gamma Receptor IIIA Promotes Rather than Suppresses Humoral and Cellular Immune Responses after Mucosal or Parenteral Immunization with Antigen and Adjuvants

M. Cragg, J. Holmgren, Z. Xiang, 2017, Scandinavian journal of immunology.

The Protective Effect against E. coli of O and K Antibodies of Different Immunoglobulin Classes

J. Holmgren, B. Kaijser, L. A. Hanson, 1972, Scandinavian journal of immunology.

Enhancement of the IgG antibody production to Escherichia coli O antigen by prior exposure to serologically different E. coli bacteria.

S. Ahlstedt, J. Holmgren, 1974, Immunology.

Antibodies to endotoxin from Vibrio cholerae measured by bactericidal and indirect hemagglutination tests. Differences in immunoglobulin classes and specificity.

J. Holmgren, A. Svennerholm, O. Ouchterlony, 1972, Journal of immunological methods.

Immunological aspects of urinary tract infections.

J. Holmgren, J. Smith, 1975, Progress in allergy.

An Antigenic Relationship Between Kidney and Certa in Escherichia coli Strains

J. Holmgren, S. Holm, B. Kaijser, 1971 .

Studies of methods for quantitation of agglutinins and precipitins to Escherichia coli O and K antigens.

J. Holmgren, 1970, International archives of allergy and applied immunology.

PRECIPITATING ANTIBODIES TO E. COLI O ANTIGENS: A SUGGESTED DIFFERENCE IN THE ANTIBODY RESPONSE OF INFANTS AND CHILDREN WITH FIRST AND RECURRENT ATTACKS OF PYELONEPHRITIS

J. Holmgren, J. Winberg, U. Jodal, 1969, Acta paediatrica Scandinavica.

30. Capsular antibodies to Escherichia coli in relation to urinary trait infectious (UTI)

J. Holmgren, B. Kaijser, U. Jodal, 1971, Pediatric Research.

The antibody response in rabbits to E. coli O antigen.

J. Holmgren, 1970, International archives of allergy and applied immunology.

The antibody response in rabbits to E. coli K antigen.

J. Holmgren, 1970, International archives of allergy and applied immunology.

Studies of Aggregates of IgG in Human Sera and Commercial γ-Globulin Preparations with a New Immuno-gel Filtration Method*

J. Holmgren, L. Hanson, C. Wadsworth, 1972 .

An antigenic relationship between human kidney, colon and the common antigen of enterobacteriaceae.

J. Holmgren, P. Attman, J. Ahlmén, 1972, International Archives of Allergy and Applied Immunology.

The bactericidal effect of normal human serum on e. coli strains from normals and from patients with urinary tract infections

J. Holmgren, U. Lindberg, K. Lincoln, 2005, Infection.

Quantitation of Escherichia coli O antibodies by direct and indirect agglutination in comparison with a radioimmunoassay.

S. Ahlstedt, J. Holmgren, L. Hanson, 1975, International Archives of Allergy and Applied Immunology.

Significance of amount and avidity of E. coli O antibodies for manifestation of their serological and protective properties. A preliminary study.

S. Ahlstedt, J. Holmgren, L. Hanson, 1972, International archives of allergy and applied immunology.

A Radial Diffusion Agar Plaque Technique for Estimation of the Avidity of Bactericidal Antibodies against Vibrio cholerae

J. Holmgren, A. Svennerholm, ANN‐MARI SVENNERHOLM, 1972, Scandinavian journal of immunology.

Antigenic relationships between kidney and enteric bacteria

R. Goldblum, J. Holmgren, 1975 .

Human circulating specific antibody‐forming cells after systemic and mucosal immunizations: differential homing commitments and cell surface differentiation markers

J. Banchereau, E. Butcher, C. Czerkinsky, 1995, European journal of immunology.

Asymptomatic bacteriuria--a serious disease?

J. Holmgren, U. Lindberg, K. Lincoln, 1972, British medical journal.

A radial immune-gel filtration method for characterization and quantitation of macromolecules.

J. Holmgren, L. Hanson, C. Wadsworth, 1971, International archives of allergy and applied immunology.

Interferon production by Shigella flexneri-infected fibroblasts depends upon intracellular bacterial metabolism

J. Holmgren, G. Jonson, D. Niesel, 1990, Infection and immunity.

ThePrimary andSecondary Antibody Response to Escherichia coli 06Lipopolysacchari de Analysed atthe Humoral andCellular Level AMOUNT AND AVIDITYOF THE ANTIBODIESIN RELATIONTO PROTECTIVE CAPACITY

S. Ahlstedt, J. Holmgren, L. Hanson, 1973 .

Cholera toxin expression by El Tor Vibrio cholerae in shallow culture growth conditions.

J. Holmgren, Å. Sjöling, G. Ayala, 2014, Microbial pathogenesis.

Cross-reactivity between heat labile enterotoxins of Vibrio cholerae and Escherichia coli in neutralization tests in rabbit ileum and skin.

J. Holmgren, T. Wadström, O. Söderlind, 2009, Acta pathologica et microbiologica Scandinavica. Section B: Microbiology and immunology.

Immunodiffusion studies of pneumococcal antigens with special reference to serotype 27.

J. Holmgren, K. Broholm, 2009, Acta pathologica et microbiologica Scandinavica. Section B: Microbiology and immunology.

Immunochemical Studies of Two Cholera Toxin-Containing Standard Culture Filtrate Preparations of Vibrio cholerae

J. Holmgren, I. Lönnroth, Ö. Ouchterlony, 1971, Infection and immunity.

Detection of caeruloplasmin in bovine milk and blood serum

J. Holmgren, L. Hanson, E. Samuelsson, 1967, Journal of Dairy Research.

Experimental studies on cholera immunization. 1. The response of neutralizing and vibriocidal antibodies in rabbits after immunization with culture filtrate material from V. cholerae.

J. Holmgren, A. Svennerholm, O. Ouchterlony, 2009, Acta pathologica et microbiologica Scandinavica. Section B: Microbiology and immunology.

Protection against Cholera Toxin after Oral Immunization is Thymus‐Dependent and Associated with Intestinal Production of Neutralizing IgA Antitoxin

J. Holmgren, N. Lycke, L. Eriksen, 1987, Scandinavian journal of immunology.

55. STUDIES OF ANTIBODIES AND IMMUNOGLOBULIN LEVELS IN URINE FROM CHILDREN WITH URINARY TRACT INFECTIONS CAUSED BY E. COLI

J. Holmgren, B. Kaijser, U. Jodal, 1970, Acta paediatrica Scandinavica. Supplement.

A mucosally administered recombinant fusion protein vaccine against schistosomiasis protecting against immunopathology and infection.

A. Capron, N. Mielcarek, C. Czerkinsky, 2003, Vaccine.

CHLORPROMAZINE REDUCES FLUID-LOSS IN CHOLERA

J. Holmgren, G. Rabbani, W. Greenough, 1979, The Lancet.

Changes in intestinal fluid and mucosal immune responses to cholera toxin in Giardia muris infection and binding of cholera toxin to Giardia muris trophozoites

A. Ferrante, J. Holmgren, A. Svennerholm, 1985, Infection and immunity.

Protective Oral Cholera Vaccine Based on a Combination of Cholera Toxin B Subunit and Inactivated Cholera Vibrios

J. Holmgren, J. Osek, A. Svennerholm, 1994 .

Oral B Subunit-Whole Cell Vaccine Against Cholera: From Basic Research to Successful Field Trial

D. Sack, J. Clemens, J. Holmgren, 1989 .

Intestinal immune response to cholera toxin: dependence on route and dosage of antigen for priming and boosting

J. Holmgren, A. Svennerholm, S. Lange, 1980, Infection and immunity.

Development of Stable Vibrio cholerae O1 Hikojima Type Vaccine Strains Co–Expressing the Inaba and Ogawa Lipopolysaccharide Antigens

M. Lebens, J. Holmgren, Stefan L. Karlsson, 2014, PloS one.

Chimeric Vaccines Against Japanese Encephalitis, Dengue, and West Nile

F. Guirakhoo, T. Monath, R. Rappuoli, 2004 .

A Fully Integrated Assay Panel for Early Drug Metabolism and Pharmacokinetics Profiling

Fredrik Bergström, Thomas Lundbäck, Johan Wernevik, 2020, Assay and drug development technologies.

Cholera

Jan Holmgren, Firdausi Qadri, John D Clemens, 2017, The Lancet.

Nasal and Vaginal Vaccinations Have Differential Effects on Antibody Responses in Vaginal and Cervical Secretions in Humans

J. Holmgren, A. Rudin, M. Jertborn, 2001, Infection and Immunity.

Broad Up-Regulation of Innate Defense Factors during Acute Cholera

Carl-Fredrik Flach, F. Qadri, J. Holmgren, 2007, Infection and Immunity.

Long-term effectiveness against cholera of oral killed whole-cell vaccine produced in Vietnam.

Jin-Kyung Park, Jan Holmgren, Lorenz von Seidlein, 2006, Vaccine.

Mucosally induced Immunological Tolerance, Regulatory T Cells and the Adjuvant Effect by Cholera Toxin B Subunit

C. Czerkinsky, J. Holmgren, Jia-bin Sun, 2009, Scandinavian journal of immunology.

Controlled trial of chlorpromazine as antisecretory agent in patients with cholera hydrated intravenously.

J. Holmgren, G. Rabbani, W. Greenough, 1982, British medical journal.

Correlation between intestinal synthesis of specific immunoglobulin A and protection against experimental cholera in mice

J. Holmgren, A. Svennerholm, S. Lange, 1978, Infection and immunity.

Helicobacter pylori Infection of the Gastric Mucosa

J. Holmgren, A. Svennerholm, S. Raghavan, 2015 .

Intranasal Immunization With an Apolipoprotein B-100 Fusion Protein Induces Antigen-Specific Regulatory T Cells and Reduces Atherosclerosis

R. Klingenberg, M. Rudling, G. Hansson, 2010, Arteriosclerosis, thrombosis, and vascular biology.

Cholera as a model for research on mucosal immunity and development of oral vaccines

C. Czerkinsky, J. Holmgren, 1992, Current Biology.

Human gastric B cell responses can be induced by intestinal immunisation

H. Lönroth, J. Holmgren, A. Svennerholm, 2001, Gut.

Chlorpromazine Reverses Diarrhea in Piglets Caused by Enterotoxigenic Escherichia coli

J. Holmgren, I. Lönnroth, K. Martinsson, 1979, Infection and immunity.

Chlorpromazine inhibits cholera toxin-induced intestinal hypersecretion.

J. Holmgren, I. Lönnroth, S. Lange, 1977, Medical biology.

Gut mucosal, salivary and serum antitoxic and antibacterial antibody responses in Swedes after oral immunization with B subunit-whole cell cholera vaccine.

J. Holmgren, A. Svennerholm, M. Jertborn, 1984, International archives of allergy and applied immunology.

Cholera toxin — A foe & a friend

Jan Holmgren, J. Holmgren, Joaquín Sánchez, 2011, The Indian journal of medical research.

Cholera toxin enhances antigen presentation.

J. Holmgren, N. Lycke, A. Bromander, 1995, Advances in experimental medicine and biology.

Cholera Due to Altered El Tor Strains of Vibrio cholerae O1 in Bangladesh

Y. Takeda, A. Faruque, D. Sack, 2006, Journal of Clinical Microbiology.

S100A4 exerts robust mucosal adjuvant activity for co-administered antigens in mice

Z. Xiang, B. Wei, J. Holmgren, 2022, Mucosal Immunology.

Oral tolerization with peptide 336–351 linked to cholera toxin B subunit in preventing relapses of uveitis in Behcet's disease

T. Whittall, L. Bergmeier, T. Lehner, 2004, Clinical and experimental immunology.

Antitoxic cholera immunity in mice: influence of antigen deposition on antitoxin-containing cells and protective immunity in different parts of the intestine.

J. Holmgren, A. Svennerholm, H. Nygren, 1980, Infection and immunity.

Deficiency in Calcium-Binding Protein S100A4 Impairs the Adjuvant Action of Cholera Toxin

Jia-Bin Sun, Jan Holmgren, A. Bresnick, 2017, Front. Immunol..

Coexpression of ganglioside antigen Fuc-GM1, neural-cell adhesion molecule, carcinoembryonic antigen, and carbohydrate tumor-associated antigen CA 50 in lung cancer.

J. Holmgren, L. Lindholm, B. Bergman, 1992, Tumour biology : the journal of the International Society for Oncodevelopmental Biology and Medicine.

Amplified ELISPOT assay for the detection of HIV-specific antibody-secreting cells in subhuman primates.

C. Czerkinsky, J. Holmgren, B. Svennerholm, 1992, Journal of immunological methods.

Sublingual Immunization with Nonreplicating Antigens Induces Antibody-Forming Cells and Cytotoxic T Cells in the Female Genital Tract Mucosa and Protects against Genital Papillomavirus Infection1

J. Schiller, C. Czerkinsky, J. Holmgren, 2009, The Journal of Immunology.

Antibodies and Antibody-Secreting Cells in the Female Genital Tract after Vaginal or Intranasal Immunization with Cholera Toxin B Subunit or Conjugates

C. Czerkinsky, J. Holmgren, K. Eriksson, 1998, Infection and Immunity.

Differential expression of tissue-specific adhesion molecules on human circulating antibody-forming cells after systemic, enteric, and nasal immunizations. A molecular basis for the compartmentalization of effector B cell responses.

E. Butcher, C. Czerkinsky, J. Holmgren, 1997, The Journal of clinical investigation.

Chapter De(cid:2) cient IgAl immune response to nasal cholera toxin subunit B in primary IgA nephropathy

M. Daha, J. Holmgren, L. Es, 2008 .

Induction and Expression of Intestinal Humoral Immunity in HIV-Infected Individuals: Prospects for Vaccination against Secondary Enteric Infections

G. Norkrans, L. Hagberg, C. Czerkinsky, 1998, Pathobiology.

Exploration of mucosal immunity in humans: relevance to vaccine development.

C. Czerkinsky, J. Holmgren, 1994, Cellular and molecular biology.

Colorectal carcinomas have a characteristic ganglioside pattern.

O. Nilsson, J. Holmgren, L. Lindholm, 1983, Medical biology.

Epitope differences in toxin-coregulated pili produced by classical and El Tor Vibrio cholerae O1.

J. Holmgren, A. Svennerholm, G. Jonson, 1991, Microbial pathogenesis.

Enterotoxin antibodies in relation to diarrhoea in Swedish soldiers in Cyprus.

J. Holmgren, A. Svennerholm, E. Bäck, 1977, Bulletin of the World Health Organization.

The maltose regulon of Vibrio cholerae affects production and secretion of virulence factors

J. Holmgren, G. Jonson, E. T. Palva, 1994, Infection and immunity.

Analysis of expression of toxin-coregulated pili in classical and El Tor Vibrio cholerae O1 in vitro and in vivo

J. Holmgren, A. Svennerholm, G. Jonson, 1992, Infection and immunity.

Enzyme‐linked immunosorbent assay for determination of antibodies to Vibrio cholere toxin‐coregulated pili

J. Holmgren, ANN‐MARI SVENNERHOLM, JACEK OSEK, 1992, APMIS : acta pathologica, microbiologica, et immunologica Scandinavica.

Purification of Vibrio cholerae soluble hemagglutinin and development of enzyme-linked immunosorbent assays for antigen and antibody quantitations

J. Holmgren, A. Svennerholm, G. J. Strömberg, 1983, Infection and immunity.

Immune Response to Vibrio cholerae Infection in Rabbits with Special Reference to Antibodies Against in vivo Specific Antigens

J. Holmgren, A. Svennerholm, G. Jonson, 1991 .

Improved medium for large-scale production of recombinant cholera toxin B subunit for vaccine purposes

M. Lebens, J. Holmgren, J. Osek, 1995 .

Weak serum and intestinal antibody responses to Vibrio cholerae soluble hemagglutinin in cholera patients

M. Levine, J. Holmgren, A. Svennerholm, 1984, Infection and immunity.

Enteric vaccines for the developing world: a challenge for mucosal immunology

C. Czerkinsky, J. Holmgren, 2009, Mucosal Immunology.

Coordinated assembly of multisubunit proteins: oligomerization of bacterial enterotoxins in vivo and in vitro.

J. Holmgren, T. Hirst, J. Sánchez, 1988, Proceedings of the National Academy of Sciences of the United States of America.

Oral Cholera Vaccines

J. Kaper, J. Holmgren, 1986, The Lancet.

Monoclonal antibodies to cholera toxin with special reference to cross-reactions with Escherichia coli heat-labile enterotoxin

J. Holmgren, L. Lindholm, N. Lycke, 1983, Infection and immunity.

Effects of Oral Vaccination and Immunomodulation by Cholera Toxin on Experimental Helicobacter pylori Infection, Reinfection, and Gastritis

J. Holmgren, A. Svennerholm, A. Svennerholm, 2002, Infection and Immunity.

Immunoglobulin and Specific-Antibody Synthesis In Vitro by Enteral and Nonenteral Lymphoid Tissues After Subcutaneous Cholera Immunization

J. Holmgren, A. Svennerholm, 1977, Infection and immunity.

PROTECTIVE ANTITOXIC CHOLERA IMMUNITY IN MICE: INFLUENCE OF ROUTE AND NUMBER OF IMMUNIZATIONS AND MODE OF ACTION OF PROTECTIVE ANTIBODIES

J. Holmgren, S. Lange, 1978, Acta pathologica et microbiologica Scandinavica. Section C, Immunology.

Development of Hillchol®, a low-cost inactivated single strain Hikojima oral cholera vaccine.

V. Kanchan, M. Lebens, J. Holmgren, 2020, Vaccine.

Monoclonal antibodies to Escherichia coli heat-labile enterotoxins: neutralising activity and differentiation of human and porcine LTs and cholera toxin.

J. Holmgren, A. Svennerholm, M. Wikström, 1986, Medical biology.

MATERNAL CHOLERA IMMUNISATION AND SECRETORY IgA IN BREAST MILK

D. Sack, J. Holmgren, A. Svennerholm, 1980, The Lancet.

Sublingual vaccination

C. Czerkinsky, J. Holmgren, F. Anjuère, 2011, Human vaccines.

Immune responses following one and two doses of the reformulated, bivalent, killed, whole-cell, oral cholera vaccine among adults and children in Kolkata, India: a randomized, placebo-controlled trial.

S. Han, J. Clemens, D. Sur, 2009, Vaccine.

Cholera Immunity and Development and Use of Oral Cholera Vaccines for Disease Control

F. Qadri, J. Clemens, J. Holmgren, 2020 .

Changes in intestinal fluid transport and immune responses to enterotoxins due to concomitant parasitic infection.

J. Holmgren, A. Svennerholm, S. Lange, 1980, Infection and immunity.

Interaction of cholera toxin and membrane GM 1 ganglioside of small intestine ( mucosal receptors

J. Holmgren, I. Lonnroth, JAN-ERIC MANSSONt, 2022 .

Oral tolerance induction by mucosal administration of cholera toxin B‐coupled antigen involves T‐cell proliferation in vivo and is not affected by depletion of CD25+ T cells

E. Telemo, C. Czerkinsky, M. Lebens, 2006, Immunology.

Antibody responses in serum and lung to intranasal immunization with Haemophilus influenzae type b polysaccharide conjugated to cholera toxin B subunit and tetanus toxoid

J. Holmgren, CHARLOTTA BERGQUIST, TERESA LAGERGÅRD, 1998, APMIS : acta pathologica, microbiologica, et immunologica Scandinavica.

Investigations into the safety and immunogenicity of a killed oral cholera vaccine developed in Viet Nam.

P. D. Cam, J. Clemens, J. Holmgren, 2002, Bulletin of the World Health Organization.

Non-O1 Vibrio cholerae in Thailand: homology with cloned cholera toxin genes

J. Holmgren, P. Echeverria, D. N. Taylor, 1985, Journal of clinical microbiology.

Immunoactive chimeric ST‐LT enterotoxins of Escherichia coli generated by in vitro gene fusion

T. Grundström, B. Uhlin, J. Holmgren, 1986, FEBS letters.

Live Oral Cholera Vaccine A Preliminary Review of its Pharmacology and Clinical Potential in Providing Protective Immunity against Cholera

J. Holmgren, P. Barrett, O. Tackett, 1995 .

Development of pathogenicity-driven definitions of outcomes for a field trial of a killed oral vaccine against enterotoxigenic Escherichia coli in Egypt: application of an evidence-based method.

R. Frenck, J. Clemens, J. Holmgren, 2004, The Journal of infectious diseases.

Cholera toxin structure, gene regulation and pathophysiological and immunological aspects

J. Holmgren, J. Sánchez, 2008, Cellular and Molecular Life Sciences.

Sublingual Immunization Protects against Helicobacter pylori Infection and Induces T and B Cell Responses in the Stomach

Carl-Fredrik Flach, C. Czerkinsky, J. Holmgren, 2010, Infection and Immunity.

Vaccines against mucosal infections.

J. Holmgren, A. Svennerholm, 2012, Current opinion in immunology.

New cholera vaccines.

D. Sack, J. Clemens, J. Holmgren, 1989, Vaccine.

Serologic differentiation between antitoxin responses to infection with Vibrio cholerae and enterotoxin-producing Escherichia coli.

M. Levine, R. Black, J. Holmgren, 1983, The Journal of infectious diseases.

Local and Systemic Immune Responses to Rectal Administration of Recombinant Cholera Toxin B Subunit in Humans

C. Czerkinsky, J. Holmgren, A. Kilander, 2001, Infection and Immunity.

The binding of colonization factor antigens of enterotoxigenic Escherichia coli to intestinal cell membrane proteins.

C. Wennerås, J. Holmgren, A. Svennerholm, 1990, FEMS microbiology letters.

New prospects for mucosal immunization: anti-infectious and anti-inflammatory vaccines

N. Mielcarek, C. Czerkinsky, M. Bäckström, 1998 .

Mucosal immune response to cholera toxin--cellular basis of memory and adjuvant action.

J. Holmgren, N. Lycke, 1988, Monographs in allergy.

Dendritic Cell-Mediated Induction of Mucosal Cytotoxic Responses following Intravaginal Immunization with the Nontoxic B Subunit of Cholera Toxin1

C. Czerkinsky, J. Holmgren, F. Anjuère, 2006, The Journal of Immunology.

Response to "questionable merits of the field trial of an oral killed whole cell cholera vaccine in Vietnam during 1998-2003" Vaccine 2007;25(8):1353-4.

J. Clemens, J. Holmgren, J. Deen, 2007, Vaccine.

Patterns of immunoglobulins in acute viral hepatitis: relation to hepatitis-associated antigen.

J. Holmgren, S. Iwarson, 1972, The Journal of infectious diseases.

Immunizations of monkeys with synthetic peptides disclose conserved areas on gp120 of human immunodeficiency virus type 1 associated with cross-neutralizing antibodies and T-cell recognition.

C. Czerkinsky, J. Holmgren, B. Svennerholm, 1991, Proceedings of the National Academy of Sciences of the United States of America.

Studies on the sensitivity of Proteus mirabilis and Proteus vulgaris to sulphonamide and colistin alone and in combination.

J. Holmgren, O. Möller, 1970, Scandinavian journal of infectious diseases.

Local Intravaginal Vaccination of the Female Genital Tract

J. Holmgren, K. Schön, N. Lycke, 1996, Scandinavian journal of immunology.

Immunological cross-reactivity between human kidney and certain E. coli and streptococcal strains.

J. Holmgren, J. Ahlmén, S. Holm, 1972, International archives of allergy and applied immunology.

Monoclonal antibodies against human papillomavirus E7 oncoprotein for diagnosis of cervical neoplasia and cancer

O. Nilsson, J. Dillner, J. Holmgren, 2012 .

Detection of human papillomavirus oncoprotein E7 in liquid-based cytology.

O. Nilsson, J. Holmgren, M. Dürst, 2012, The Journal of general virology.

Detection of human papillomavirus oncoprotein E 7 in liquid-based cytology

O. Nilsson, J. Holmgren, M. Dürst, 2012 .

Gangliosides as Receptors for Cholera Toxin, Tetanus Toxin, and Sendai Virus

Ö. Strannegård, H. Elwing, J. Holmgren, 1980 .

CpG DNA as a potent inducer of mucosal immunity: implications for immunoprophylaxis and immunotherapy of mucosal infections.

J. Holmgren, A. Harandi, 2004, Current opinion in investigational drugs.

Anatomic Segmentation of the Intestinal Immune Response in Nonhuman Primates: Differential Distribution of B Cells after Oral and Rectal Immunizations to Sites Defined by Their Source of Vascularization

C. Czerkinsky, J. Holmgren, J. Osek, 1999, Infection and Immunity.

An optimized automated assay for determination of metabolic stability using hepatocytes: assay validation, variance component analysis, and in vivo relevance.

Brian Middleton, L. Gustavsson, J. Holmgren, 2007, Assay and drug development technologies.

Characterization of an internal permissive site in the cholera toxin B-subunit and insertion of epitopes from human immunodeficiency virus-1, hepatitis B virus and enterotoxigenic Escherichia coli.

M. Lebens, J. Holmgren, F. Schödel, 1995, Gene.

Phage display for site-specific immunization and characterization of high-risk human papillomavirus specific E7 monoclonal antibodies.

O. Nilsson, J. Holmgren, C. Hall, 2008, Journal of immunological methods.

5 year effi cacy of a bivalent killed whole-cell oral cholera vaccine in Kolkata , India : a cluster-randomised , double-blind , placebo-controlled trial

A. Donner, S. Niyogi, J. Clemens, 2013 .

A thermostable, dry formulation inactivated Hikojima whole cell/cholera toxin B subunit oral cholera vaccine.

M. Lebens, J. Holmgren, Susanne Källgård, 2023, Vaccine.

Suppression of HIV replication in vitro by CpG and CpG conjugated to the non toxic B subunit of cholera toxin.

E. Fenyö, J. Holmgren, A. Harandi, 2008, Current HIV research.

Intestinal immune responsiveness in HIV-infected individuals.

G. Norkrans, L. Hagberg, C. Czerkinsky, 1995, Advances in experimental medicine and biology.

3.8. Oral Vaccination, Mucosal Immunity and Oral Tolerance with Special Reference to Cholera Toxin

C. Czerkinsky, J. Holmgren, A. Svennerholm, 1996 .

Proteomic analysis of cholera toxin adjuvant-stimulated human monocytes identifies Thrombospondin-1 and Integrin-β1 as strongly upregulated molecules involved in adjuvant activity

M. Lebens, J. Holmgren, Maximilian Larena, 2019, Scientific Reports.

CpG oligodeoxynucleotide augments HSV-2 glycoprotein D DNA vaccine efficacy to generate T helper 1 response and subsequent protection against primary genital herpes infection in mice.

J. Holmgren, A. Harandi, Sara Tengvall, 2005, Journal of reproductive immunology.

Vaccine Protection of Bangladeshi Infants and Young Children Against Cholera: Implications for Vaccine Deployment and Person-to-Person Transmission

D. Sack, M. Yunus, M. Emch, 2008, The Pediatric infectious disease journal.

Prolonged oral treatment with low doses of allergen conjugated to cholera toxin B subunit suppresses immunoglobulin E antibody responses in sensitized mice.

C. Czerkinsky, J. Holmgren, J. Sun, 2000, Clinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology.

Adoptive transfer of mucosal T cells or dendritic cells from animals fed with cholera toxin B subunit alloantigen conjugate induces allogeneic T cell tolerance.

J. Holmgren, J. Sun, B. L. Li, 2001, Advances in experimental medicine and biology.

Structure and Function of Enterotoxins and Their Receptors

J. Holmgren, I. Lönnroth, 1980 .

Nobelstiftelsen, J. Holmgren, Ö. Ouchterlony, 1980 .

CHAPTER 61 – Engineered bacterial toxin vaccines and adjuvants

J. Holmgren, A. Svennerholm, 2006 .

Isolation ofEscherichia coli heat-labile enterotoxin by affinity chromatography: Characterization of subunits

J. Holmgren, A. Svennerholm, M. Wolk, 1980, Current Microbiology.

Immunoassays based on plastic-adsorbed gangliosides.

H. Elwing, J. Holmgren, L. Svennerholm, 1980, Advances in experimental medicine and biology.

Preclinical immunogenicity and protective efficacy of an oral Helicobacter pylori inactivated whole cell vaccine and multiple mutant cholera toxin: A novel and non-toxic mucosal adjuvant.

M. Lebens, J. Holmgren, M. Blomquist, 2018, Vaccine.

Fusion of genes encoding Escherichia coli heat-stable enterotoxin and outer membrane protein OmpC

J. Holmgren, E. T. Palva, J. Sánchez, 1989, Infection and immunity.

Insertion of a HIV-1-neutralizing epitope in a surface-exposed internal region of the cholera toxin B-subunit.

M. Bäckström, M. Lebens, J. Holmgren, 1994, Gene.

Urgent need of cholera vaccines in public health-control programs.

J. Clemens, J. Holmgren, 2009, Future microbiology.

Chemical modification of cholera toxin for characterization of antigenic receptor‐binding and toxic sites

J. Holmgren, I. Lönnroth, 1974, FEBS letters.

Mucosal vaccines based on the use of cholera toxin B subunit as immunogen and antigen carrier.

M. Lebens, J. Holmgren, 1994, Developments in biological standardization.

Stool cyclic AMP in diarrhoea due to different causative organisms.

J. Holmgren, F. Jahan, A. Molla, 1985, Journal of diarrhoeal diseases research.

IgG and IgA subclass distribution of antitoxin antibody responses after oral cholera vaccination or cholera disease.

J. Holmgren, A. Svennerholm, M. Jertborn, 1988, International archives of allergy and applied immunology.

Novel Immunostimulatory Agent Based on CpG Oligodeoxynucleotide Linked to the Nontoxic B Subunit of Cholera Toxin1

J. Holmgren, A. Harandi, A. Lundqvist, 2006, The Journal of Immunology.

Nontoxic B Subunit of Cholera Toxin CpG Oligodeoxynucleotide Linked to the Novel Immunostimulatory Agent Based on

J. Holmgren, A. Harandi, M. Lindblad, 2006 .

Intestinal antibody responses to oral vaccination in HIV‐infected individuals

G. Norkrans, L. Hagberg, C. Czerkinsky, 1993, AIDS.

Depth profiling of cells and tissues by using C60+ and SF5+ as sputter ions

H. Arlinghaus, B. Hagenhoff, J. Holmgren, 2008 .

Immunohistochemical detection of two small cell lung carcinoma‐associated antigens defined by MAbs F12 and 123C3 in bronchoscopy biopsy tissues

J. Holmgren, L. Lindholm, B. Bergman, 1991, APMIS : acta pathologica, microbiologica, et immunologica Scandinavica.

Serotype has a significant impact on the virulence of 7th pandemic Vibrio cholerae O1

M. Lebens, J. Holmgren, Kaisa Thorell, 2020, bioRxiv.

Proteomic analysis of cholera toxin adjuvant-stimulated human monocytes identifies Thrombospondin-1 and Integrin-β1 as strongly upregulated molecules involved in adjuvant activity

M. Lebens, J. Holmgren, Maximilian Larena, 2019, Scientific Reports.

Mucosal immunity and vaccination.

J. Holmgren, J. Holmgren, 1991, FEMS microbiology immunology.

Cholera toxin and cholera B subunit as oral-mucosal adjuvant and antigen vector systems.

C. Czerkinsky, J. Holmgren, N. Lycke, 1993, Vaccine.

Cross-protection by B subunit-whole cell cholera vaccine against diarrhea associated with heat-labile toxin-producing enterotoxigenic Escherichia coli: results of a large-scale field trial.

D. Sack, J. Harris, J. Chakraborty, 1988, The Journal of infectious diseases.

Single-strain improved oral cholera vaccine : scientific report- Jan Holmgren

J. Holmgren, 2015 .

Field trial of oral cholera vaccines in Bangladesh: serum vibriocidal and antitoxic antibodies as markers of the risk of cholera.

D. Sack, J. Harris, F. van Loon, 1991, The Journal of infectious diseases.

Identification and characterization of cholera exotoxin in culture filtrates of V. cholerae.

J. Holmgren, O. Ouchterlony, I. Lönnroth, 1971, Acta pathologica et microbiologica Scandinavica. Section B: Microbiology and immunology.

Exclusion of clinically atypical or microbiologically mixed diarrhoeal episodes from outcome events in a field trial of oral cholera vaccines.

Yunus, D. Sack, J. Harris, 1989, International journal of epidemiology.

Orally Administered CpG Oligodeoxynucleotide Induces Production of CXC and CC Chemokines in the Gastric Mucosa and Suppresses Bacterial Colonization in a Mouse Model of Helicobacter pylori Infection

J. Holmgren, A. Harandi, S. Raghavan, 2003, Infection and Immunity.

QUANTISATION OF VIBRIOCIDAL ANTIBODIES USING AGAR PLAQUE TECHNIQUES

J. Holmgren, A. Svennerholm, Ö. Ouchterlony, 2009 .

Absence of CD4+CD25+ regulatory T cells is associated with a loss of regulation leading to increased pathology in Helicobacter pylori‐infected mice

J. Holmgren, A. Svennerholm, S. Raghavan, 2003, Clinical and experimental immunology.

Recent developments in mucosal immunomodulatory adjuvants.

J. Holmgren, A. Harandi, K. Eriksson, 2003, Current opinion in investigational drugs.

M. Petzold, J. Holmgren, A. Svennerholm, 2014, Vaccine.

Preparation and evaluation of a freeze-dried oral killed cholera vaccine formulation.

A. Larsson, J. Holmgren, E. Nygren, 2011, European journal of pharmaceutics and biopharmaceutics.

Preparation and preclinical evaluation of a freeze-dried formulation of a novel combined multivalent whole-cell/B-subunit oral vaccine against enterotoxigenic Escherichia coli diarrhea.

A. Larsson, J. Holmgren, A. Ekman, 2016, European journal of pharmaceutics and biopharmaceutics : official journal of Arbeitsgemeinschaft fur Pharmazeutische Verfahrenstechnik e.V.

Murine antibody responses following systemic or mucosal immunization with viable or inactivated Vibrio cholerae.

J. Holmgren, E. Nygren, S. Attridge, 2008, Vaccine.

A clinical study of CA-50 as a tumour marker for monitoring of colorectal cancer

L. Påhlman, O. Nilsson, J. Holmgren, 1988, Medical oncology and tumor pharmacotherapy.

Generalized and Compartmentalized Mucosal Immune Responses in Humans: Cellular and Molecular Aspects

J. Banchereau, E. Butcher, C. Czerkinsky, 1996 .

Sublingual Immunization Protects against Helicobacter pylori Infection and Induces T and B Cell Responses in the Stomach

Carl-Fredrik Flach, C. Czerkinsky, J. Holmgren, 2010, Infection and Immunity.

Relative significance of mannose-sensitive hemagglutinin and toxin-coregulated pili in colonization by Vibrio cholerae El Tor

J. Holmgren, S. Attridge, P. Manning, 1996 .