J. Coburn

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High Prevalence of Spirochetosis in Cholera Patients, Bangladesh

Eric J. Nelson, A. Camilli, S. Calderwood, 2009, Emerging infectious diseases.

Leptospira as an emerging pathogen: a review of its biology, pathogenesis and host immune responses.

J. Coburn, K. Evangelista, Jenifer Coburn, 2010, Future microbiology.

Several GTP-binding proteins, including p21c-H-ras, are preferred substrates of Pseudomonas aeruginosa exoenzyme S.

R. Wyatt, J. Coburn, D. Gill, 1989, The Journal of biological chemistry.

Live Attenuated Borrelia burgdorferi Targeted Mutants in an Infectious Strain Background Protect Mice from Challenge Infection

B. Hahn, J. Coburn, Laura C Ristow, 2016, Clinical and Vaccine Immunology.

Leptospira interrogans causes quantitative and morphological disturbances in adherens junctions and other biological groups of proteins in human endothelial cells

J. Coburn, Hiromi Sato, 2017, PLoS neglected tropical diseases.

Recognition of Multiple Antibody Epitopes throughout Borrelia burgdorferi p66, a Candidate Adhesin, in Patients with Early or Late Manifestations of Lyme Disease

A. Steere, J. Coburn, H. Rothermel, 2001, Infection and Immunity.

Borrelia burgdorferi outer surface protein C (OspC) binds complement component C4b and confers bloodstream survival

J. Coburn, J. Leong, Yi-Pin Lin, 2017, Cellular microbiology.

Strain-specific joint invasion and colonization by Lyme disease spirochetes is promoted by outer surface protein C

J. Coburn, J. Leong, Yi-Pin Lin, 2020, PLoS pathogens.

A natural variant of the cysteine protease virulence factor of group A Streptococcus with an arginine-glycine-aspartic acid (RGD) motif preferentially binds human integrins αvβ3 and αIIbβ3

J. Musser, Mengyao Liu, S. Bodary, 1999 .

A natural variant of the cysteine protease virulence factor of group A Streptococcus with an arginine-glycine-aspartic acid (RGD) motif preferentially binds human integrins alphavbeta3 and alphaIIbbeta3.

J. Musser, S. Bodary, J. Coburn, 1999, Proceedings of the National Academy of Sciences of the United States of America.

Integrins αvβ3 and α5β1 Mediate Attachment of Lyme Disease Spirochetes to Human Cells

S. Bodary, J. Coburn, J. Leong, 1998, Infection and Immunity.

Platelet activation by a relapsing fever spirochaete results in enhanced bacterium–platelet interaction via integrin αIIbβ3 activation

T. Schwan, A. Michelson, J. Coburn, 2001, Molecular microbiology.

Integrins a v b 3 and a 5 b 1 Mediate Attachment of Lyme Disease Spirochetes to Human Cells

S. Bodary, J. Coburn, J. Leong, 1998 .

Leptospira interrogans Binds to Cadherins

Andrew J Schwab, J. Coburn, K. Evangelista, 2014, PLoS neglected tropical diseases.

An extracellular Leptospira interrogans leucine‐rich repeat protein binds human E‐ and VE‐cadherins

J. Coburn, A. Haouz, J. Bellalou, 2018, Cellular microbiology.

Borrelia burgdorferi BBB07 interaction with integrin alpha3beta1 stimulates production of pro-inflammatory mediators in primary human chondrocytes.

J. Coburn, L. Bourassa, C. Cugini, 2008, Cellular microbiology.

ADP-Ribosylation of Small GTPases by Clostridium botulinum Exoenzyme C3 and Pseudomonas aeruginosa Exoenzyme S

J. Coburn, 1993 .

ADP-ribosylation of p21ras and related proteins by Pseudomonas aeruginosa exoenzyme S

J. Coburn, D. Gill, Jenifer Coburn, 1991, Infection and immunity.

The Borrelia burgdorferi Integrin Ligand P66 Affects Gene Expression by Human Cells in Culture

M. Lafrance, J. Coburn, J. Pierce, 2011, Infection and Immunity.

Solving a sticky problem: new genetic approaches to host cell adhesion by the Lyme disease spirochete

J. Coburn, J. Leong, Joshua R. Fischer, 2005, Molecular microbiology.

A Short-Term Borrelia burgdorferi Infection Model Identifies Tissue Tropisms and Bloodstream Survival Conferred by Adhesion Proteins

J. Coburn, Jennifer A Caine, 2015, Infection and Immunity.

Identification of a TLR-Independent Pathway for Borrelia burgdorferi-Induced Expression of Matrix Metalloproteinases and Inflammatory Mediators through Binding to Integrin α3β11

S. Akira, S. Uematsu, J. Coburn, 2006, The Journal of Immunology.

Identification of a TLR-Independent Pathway

S. Uematsu, J. Coburn, Linden T. Hu, 2006 .

Regulation of Expression of the Borrelia burgdorferi β3-Chain Integrin Ligand, P66, in Ticks and in Culture

T. Schwan, J. Coburn, C. Cugini, 2003, Infection and Immunity.

Different Classes of Proteoglycans Contribute to the Attachment of Borrelia burgdorferi to Cultured Endothelial and Brain Cells

J. Coburn, J. B. Tatro, J. Leong, 1998, Infection and Immunity.

Diverse Lyme disease spirochetes bind integrin alpha IIb beta 3 on human platelets

S. Barthold, J. Coburn, J. Leong, 1994, Infection and immunity.

Prominent expression of mRNA for proinflammatory cytokines in synovium in patients with juvenile rheumatoid arthritis or chronic Lyme arthritis.

B. Alman, A. Steere, R. Ruthazer, 2000, The Journal of rheumatology.

Identification of amino acid domains of Borrelia burgdorferi P66 that are surface exposed and important for localization, oligomerization, and porin function of the protein

B. Hahn, S. Bergström, J. Coburn, 2022, Frontiers in Cellular and Infection Microbiology.

Reproducible and Quantitative Model of Infection of Dermacentor variabilis with the Live Vaccine Strain of Francisella tularensis

J. Coburn, D. Frank, M. Casey, 2014, Applied and Environmental Microbiology.

Characterization of Pseudomonas aeruginosa Exoenzyme S as a Bifunctional Enzyme in J774A.1 Macrophages

J. Coburn, E. A. Rucks, J. Olson, 2003, Infection and Immunity.

ADP-ribosylation of membrane proteins by bacterial toxins in the presence of NAD glycohydrolase.

J. Coburn, D. Gill, 1988, Biochimica et biophysica acta.

Exoenzyme S of Pseudomonas aeruginosa ADP-ribosylates the intermediate filament protein vimentin

J. Coburn, D. Gill, B. Iglewski, 1989, Infection and immunity.

Pathogenesis insights from an ancient and ubiquitous spirochete

C. Woods, T. Veldman, J. Coburn, 2021, PLoS pathogens.

Responses of Human Endothelial Cells to Pathogenic and Non-Pathogenic Leptospira Species

J. Coburn, M. Fahey, Denise G. Martinez-Lopez, 2010, PLoS neglected tropical diseases.

Integrin binding by B orrelia burgdorferi P66 facilitates dissemination but is not required for infectivity

B. Hahn, S. Bergström, J. Coburn, 2015, Cellular microbiology.

Hematogenous dissemination of pathogenic and non-pathogenic Leptospira in a short-term murine model of infection

B. Hahn, J. Coburn, Matthew C. Surdel, 2022, Frontiers in cellular and infection microbiology.

Integrin Inflammatory Mediators through Binding to of Matrix Metalloproteinases and-Induced Expression Borrelia burgdorferi for Identification of a TLR-Independent Pathway

S. Akira, S. Uematsu, J. Coburn, 2006 .

Elimination of channel-forming activity by insertional inactivation of the p66 gene in Borrelia burgdorferi.

R. Benz, S. Bergström, J. Coburn, 2007, FEMS microbiology letters.

VlsE, the nexus for antigenic variation of the Lyme disease spirochete, also mediates early bacterial attachment to the host microvasculature under shear force

B. Hahn, J. Coburn, J. Leong, 2022, PLoS pathogens.

Evaluation of Cell Binding Activities of Leptospira ECM Adhesins

B. Hahn, J. Coburn, G. T. Robbins, 2015, PLoS neglected tropical diseases.

Leptospira interrogans Binds to Human Cell Surface Receptors Including Proteoglycans

J. Nováková, J. Coburn, R. Salvador, 2009, Infection and Immunity.

Jana Proteoglycans Cell Surface Receptors Including Binds to Human Leptospira interrogans

J. Nováková, J. Coburn, R. Salvador, 2009 .

Integrin CqIbP3 mediates binding of the Lyme disease agent Borrelia burgdorferi to human platelets

J. Coburn, J. Leong, John K. ERBANt, 2005 .

Hemagglutination and proteoglycan binding by the Lyme disease spirochete, Borrelia burgdorferi

J. Coburn, J. Leong, M. Pereira, 1995, Infection and immunity.

Integrin alpha IIb beta 3 mediates binding of the Lyme disease agent Borrelia burgdorferi to human platelets.

J. Coburn, J. Leong, J. Erban, 1993, Proceedings of the National Academy of Sciences of the United States of America.

Effect of Borrelia burgdorferi OspC at the Site of Inoculation in Mouse Skin

J. Coburn, Laura C Ristow, J. Mccarthy, 2010, Infection and Immunity.

Heterologous production of the adhesin LIC13411 from pathogenic Leptospira facilitates binding of non-pathogenic Leptospira in vitro and in vivo

B. Hahn, J. Coburn, Matthew C. Surdel, 2022, Frontiers in Cellular and Infection Microbiology.

Pseudomonas aeruginosa exoenzyme S requires a eukaryotic protein for ADP-ribosyltransferase activity.

A. Kane, J. Coburn, D. Gill, 1991, The Journal of biological chemistry.

The emergence of Lyme disease.

A. Steere, J. Coburn, Allen C Steere, 2004, The Journal of clinical investigation.

D. Michael Gill (1940–1990)

J. Coburn, R. Finkelstein, B. Dickey, 1991 .

Assay and purification of cytosolic factor required for cholera toxin activity.

J. Coburn, D. Gill, M. Woolkalís, 1988, Methods in enzymology.

ADP-ribosylation by cholera toxin: functional analysis of a cellular system that stimulates the enzymic activity of cholera toxin fragment A1.

J. Coburn, D. Gill, 1987, Biochemistry.

Why Does Cholera Toxin Need GTP to Act

J. Coburn, D. Gill, 1985 .

Targeted mutation of the outer membrane protein P66 disrupts attachment of the Lyme disease agent, Borrelia burgdorferi, to integrin αvβ3

J. Coburn, C. Cugini, 2003, Proceedings of the National Academy of Sciences of the United States of America.

The eukaryotic host factor that activates exoenzyme S of Pseudomonas aeruginosa is a member of the 14-3-3 protein family.

R. Collier, J. Coburn, R. Collier, 1993, Proceedings of the National Academy of Sciences of the United States of America.

Recent discoveries and advancements in research on the Lyme disease spirochete Borrelia burgdorferi

J. Coburn, Christa H Winslow, 2019, F1000Research.

Delineation of Borrelia burgdorferi p66 Sequences Required for Integrin αIIbβ3 Recognition

J. Coburn, G. Defoe, 2001, Infection and Immunity.

Characterization of a candidate Borrelia burgdorferiβ3‐chain integrin ligand identified using a phage display library

S. Bodary, J. Coburn, J. Leong, 1999, Molecular microbiology.

Lyme Disease Pathogenesis.

S. Norris, B. Garcia, Mollie W. Jewett, 2020, Current issues in molecular biology.

Intravital Imaging of Vascular Transmigration by the Lyme Spirochete: Requirement for the Integrin Binding Residues of the B. burgdorferi P66 Protein

P. Kubes, J. Coburn, G. Chaconas, 2015, PLoS pathogens.

Targeted mutation of the outer membrane protein P66 disrupts attachment of the Lyme disease agent, Borrelia burgdorferi, to integrin alphavbeta3.

J. Coburn, C. Cugini, 2003, Proceedings of the National Academy of Sciences of the United States of America.

Borrelia burgdorferi adhesins identified using in vivo phage display

M. Lafrance, J. Coburn, Styliani Antonara, 2007, Molecular microbiology.

Glycosaminoglycan binding by Borrelia burgdorferi adhesin BBK32 specifically and uniquely promotes joint colonization

J. Coburn, J. Leong, Yi-Pin Lin, 2015, Cellular microbiology.

Borrelia burgdorferi and its tropisms for adhesion molecules in the joint.

J. Coburn, C. Cugini, Melisa S. Medrano, 2002, Current opinion in rheumatology.

Adhesion mechanisms of Borrelia burgdorferi.

J. Coburn, Laura C Ristow, Styliani Antonara, 2011, Advances in experimental medicine and biology.

Macrophages and Epithelial Cells Respond Differently to the Pseudomonas aeruginosa Type III Secretion System

J. Coburn, D. Frank, 1999, Infection and Immunity.

Borrelia burgdorferi, an extracellular pathogen, circumvents osteopontin in inducing an inflammatory cytokine response

G. F. Weber, J. Coburn, L. Glickstein, 2005, Journal of leukocyte biology.

Multifunctional and Redundant Roles of Borrelia burgdorferi Outer Surface Proteins in Tissue Adhesion, Colonization, and Complement Evasion

J. Coburn, Jennifer A Caine, 2016, Front. Immunol..

The Emergence of Severe Pulmonary Hemorrhagic Leptospirosis: Questions to Consider

J. Coburn, K. N. Truong, 2012, Front. Cell. Inf. Microbio..

References Eqallibdum within Isolated Domains

J. Coburn, Dickey, Burton, 2022 .

Illuminating the roles of the Borrelia burgdorferi adhesins.

J. Coburn, J. Leong, G. Chaconas, 2013, Trends in microbiology.

Regulators of Expression of the Oligopeptide Permease A Proteins of Borrelia burgdorferi

Yanpeng Ding, J. Coburn, Linden T. Hu, 2007, Journal of bacteriology.

Borrelia burgdorferi BBB07 interaction with integrin α3β1 stimulates production of pro‐inflammatory mediators in primary human chondrocytes

J. Coburn, L. Bourassa, C. Cugini, 2007 .

ASSOCIATION OF MACROPHAGE INFLAMMATORY RESPONSE AND CELL DEATH AFTER IN VITRO BORRELIA BURGDORFERI INFECTION WITH ARTHRITIS RESISTANCE

J. Coburn, L. Glickstein, Jenifer Coburn, 2006 .

Integrins alpha(v)beta3 and alpha5beta1 mediate attachment of lyme disease spirochetes to human cells.

S. Bodary, J. Coburn, J. Leong, 1998, Infection and immunity.

Lack of Borrelia burgdorferi DNA in synovial samples from patients with antibiotic treatment-resistant Lyme arthritis.

A. Steere, J. Coburn, B. Bloom, 1999, Arthritis and rheumatism.

Arresting Features of Bacterial Toxins

J. Coburn, J. Leong, 2000, Science.

Method to Overcome Inefficiencies in Site-Directed Mutagenesis of A/T-Rich DNA.

J. Coburn, Christa H Winslow, Samuel A. DeCero, 2020, Journal of biomolecular techniques : JBT.

Adhesion mechanisms of the Lyme disease spirochete, Borrelia burgdorferi.

J. Coburn, 2001, Current drug targets. Infectious disorders.

Identification of Cell-Binding Adhesins of Leptospira interrogans

A. Ko, B. Hahn, Elsio A. Wunder, 2014, PLoS neglected tropical diseases.

Real-Time High Resolution 3D Imaging of the Lyme Disease Spirochete Adhering to and Escaping from the Vasculature of a Living Host

P. Kubes, M. Norman, P. Colarusso, 2008, PLoS pathogens.

Characterization of Stress and Innate Immunity Resistance of Wild-Type and Δp66 Borrelia burgdorferi

B. Hahn, J. Coburn, Chunhao Li, 2017, Infection and Immunity.

Different Classes of Proteoglycans Contribute to the Attachment of Borrelia burgdorferi to Cultured Endothelial and Brain Cells

J. Coburn, J. B. Tatro, J. Leong, 1998, Infection and Immunity.

Interaction of Borrelia burgdorferi Hbb with the p66 promoter

T. Schwan, J. Coburn, P. Policastro, 2009, Nucleic acids research.

The β3‐integrin ligand of Borrelia burgdorferi is critical for infection of mice but not ticks

Halli E. Miller, J. Coburn, N. Salzman, 2012, Molecular microbiology.

Host cell heparan sulfate glycosaminoglycans are ligands for OspF‐related proteins of the Lyme disease spirochete

J. Coburn, J. Leong, Yi-Pin Lin, 2015, Cellular microbiology.

The Differential Effects of GABA‐Transaminase Inactivation in the Chick Retina and Brain

J. Coburn, R. Rando, D. Parkinson, 1982, Journal of neurochemistry.