C. Vacca

发表

IL-12, and IFN- , α Bacterial Shock: Suppression of TNF- IL-9 Protects Mice from Gram-Negative

J. Renauld, U. Grohmann, P. Puccetti, 2013 .

IL-9 Protects Mice from Gram-Negative Bacterial Shock: Suppression of TNF-α, IL-12, and IFN-γ, and Induction of IL-10

J. Renauld, U. Grohmann, P. Puccetti, 2000, The Journal of Immunology.

lymphokynes Increased GILZ expression in transgenic mice up-regulates TH-2

S. Cuzzocrea, C. Riccardi, C. Vacca, 2011 .

Increased GILZ expression in transgenic mice up-regulates Th-2 lymphokines.

E. Mazzon, S. Cuzzocrea, C. Riccardi, 2006, Blood.

The Combined Effects of Tryptophan Starvation and Tryptophan Catabolites Down-Regulate T Cell Receptor ζ-Chain and Induce a Regulatory Phenotype in Naive T Cells1

U. Grohmann, M. L. Belladonna, C. Orabona, 2006, The Journal of Immunology.

Indoleamine 2,3-dioxygenase is a signaling protein in long-term tolerance by dendritic cells

S. Bicciato, L. Boon, U. Grohmann, 2011, Nature Immunology.

IL-23 and IL-12 Have Overlapping, but Distinct, Effects on Murine Dendritic Cells1

J. Renauld, U. Grohmann, M. L. Belladonna, 2002, The Journal of Immunology.

A Crucial Role for Tryptophan Catabolism at the Host/Candida albicans Interface1

P. Puccetti, C. Vacca, P. Mosci, 2005, The Journal of Immunology.

Metabotropic glutamate receptor-4 modulates adaptive immunity and restrains neuroinflammation

S. Bicciato, F. Nicoletti, U. Grohmann, 2010, Nature Medicine.

Non-hematopoietic cells contribute to protective tolerance to Aspergillus fumigatus via a TRIF pathway converging on IDO

F. Aversa, A. Luca, C. Vacca, 2010, Cellular and Molecular Immunology.

Modulation of natriuretic peptide receptors in human adipose tissue: molecular mechanisms behind the “natriuretic handicap” in morbidly obese patients

C. Orabona, C. Vacca, G. Lupattelli, 2017, Translational research : the journal of laboratory and clinical medicine.

Th17/Treg imbalance in murine cystic fibrosis is linked to indoleamine 2,3-dioxygenase deficiency but corrected by kynurenines.

A. De Luca, P. Puccetti, C. Vacca, 2013, American journal of respiratory and critical care medicine.

High doses of CpG oligodeoxynucleotides stimulate a tolerogenic TLR9–TRIF pathway

L. Boon, A. De Luca, U. Grohmann, 2013, Nature Communications.

Murine Plasmacytoid Dendritic Cells Initiate the Immunosuppressive Pathway of Tryptophan Catabolism in Response to CD200 Receptor Engagement1

G. Trinchieri, U. Grohmann, P. Puccetti, 2004, The Journal of Immunology.

LPS-conditioned dendritic cells confer endotoxin tolerance contingent on tryptophan catabolism.

L. Boon, U. Grohmann, G. Mondanelli, 2015, Immunobiology.

Defective tryptophan catabolism underlies inflammation in mouse chronic granulomatous disease

U. Grohmann, P. Puccetti, A. Luca, 2008, Nature.

Macrophages and Modulation by IFN- Positive Regulatory Role of IL-12 in

U. Grohmann, M. L. Belladonna, C. Orabona, 2013 .

Induce a Regulatory Phenotype in Naive T-Chain and ζ DownRegulate T Cell Receptor Starvation and Tryptophan Catabolites The Combined Effects of Tryptophan Puccetti

U. Grohmann, M. L. Belladonna, C. Orabona, 2006 .

the Host/ A Crucial Role for Tryptophan Catabolism at

P. Puccetti, C. Vacca, P. Mosci, 2005 .

Tryptophan catabolism in nonobese diabetic mice.

U. Grohmann, M. L. Belladonna, C. Orabona, 2003, Advances in experimental medicine and biology.

IL-12 acts selectively on CD8 alpha- dendritic cells to enhance presentation of a tumor peptide in vivo.

U. Grohmann, M. L. Belladonna, P. Puccetti, 1999, Journal of immunology.

Reverse signaling through GITR ligand enables dexamethasone to activate IDO in allergy

L. Boon, C. Riccardi, U. Grohmann, 2007, Nature Medicine.

IDO1 suppresses inhibitor development in hemophilia A treated with factor VIII.

D. Fuchs, L. Boon, A. Iorio, 2015, The Journal of clinical investigation.

Melatonin modulates Nrf2 activity to protect porcine pre‐pubertal Sertoli cells from the abnormal H2O2 generation and reductive stress effects of cadmium

G. Cruciani, C. Vacca, D. Giustarini, 2022, Journal of pineal research.

CD40 Ligand and CTLA-4 Are Reciprocally Regulated in the Th1 Cell Proliferative Response Sustained by CD8+ Dendritic Cells1

U. Grohmann, P. Puccetti, R. Bianchi, 2002, The Journal of Immunology.

Allosteric modulation of metabotropic glutamate receptor 4 activates IDO1-dependent, immunoregulatory signaling in dendritic cells

S. Bicciato, A. Solari, U. Grohmann, 2016, Neuropharmacology.

IL-6 Inhibits the Tolerogenic Function of CD8α+ Dendritic Cells Expressing Indoleamine 2,3-Dioxygenase1

C. Uyttenhove, U. Grohmann, M. L. Belladonna, 2001, The Journal of Immunology.

CD40 ligation prevents onset of tolerogenic properties in human dendritic cells treated with CTLA-4-Ig.

A. Velardi, U. Grohmann, C. Orabona, 2005, Microbes and infection.

Th1 and Th2 Cell Clones to a Poorly Immunogenic Tumor Antigen Initiate CD8+ T Cell-Dependent Tumor Eradication In Vivo1

U. Grohmann, P. Puccetti, R. Bianchi, 2000, Journal of Immunology.

Novel mutations in the WFS1 gene are associated with Wolfram syndrome and systemic inflammation

U. Grohmann, G. Mondanelli, M. L. Belladonna, 2021, Human molecular genetics.

as Mediated by CD40 Versus B7 Activation Functional Plasticity of Dendritic Cell Subsets

U. Grohmann, C. Orabona, P. Puccetti, 2013 .

Functional Plasticity of Dendritic Cell Subsets

U. Grohmann, C. Orabona, P. Puccetti, 2003 .

Distinct, Effects on Murine Dendritic Cells IL-23 and IL-12 Have Overlapping, but

J. Renauld, M. L. Belladonna, P. Puccetti, 2013 .

A GpC-Rich Oligonucleotide Acts on Plasmacytoid Dendritic Cells To Promote Immune Suppression

A. De Luca, U. Grohmann, M. L. Belladonna, 2012, The Journal of Immunology.

Immune Suppression Plasmacytoid Dendritic Cells To Promote A GpC-Rich Oligonucleotide Acts on

U. Grohmann, M. L. Belladonna, P. Puccetti, 2012 .

Immunosuppression Via Tryptophan Catabolism: The Role of Kynurenine Pathway Enzymes

U. Grohmann, M. L. Belladonna, C. Orabona, 2007, Transplantation.

Functional expression of indoleamine 2,3-dioxygenase by murine CD8 alpha(+) dendritic cells.

D. Keskin, U. Grohmann, M. L. Belladonna, 2002, International immunology.

CpG Type A Induction of an Early Protective Environment in Experimental Multiple Sclerosis

P. Puccetti, C. Volpi, C. Vacca, 2017, Mediators of inflammation.

Tryptophan catabolism generates autoimmune-preventive regulatory T cells.

U. Grohmann, M. L. Belladonna, C. Orabona, 2006, Transplant immunology.

IL-23 neutralization protects mice from Gram-negative endotoxic shock.

U. Grohmann, M. L. Belladonna, P. Puccetti, 2006, Cytokine.

A Defect in Tryptophan Catabolism Impairs Tolerance in Nonobese Diabetic Mice

U. Grohmann, C. Orabona, P. Puccetti, 2003, The Journal of experimental medicine.

Childhood survivors of high‐risk neuroblastoma show signs of immune recovery and not immunosenescence

C. Vacca, J. Štěrba, T. Zelante, 2020, European journal of immunology.

Autocrine IL-12 is involved in dendritic cell modulation via CD40 ligation.

U. Grohmann, M. L. Belladonna, P. Puccetti, 1999, Journal of immunology.

Vivo T Cell-Dependent Tumor Eradication In + Immunogenic Tumor Antigen Initiate CD8 Th1 and Th2 Cell Clones to a Poorly

U. Grohmann, P. Puccetti, R. Bianchi, 2000 .

Distinct roles of immunoreceptor tyrosine‐based motifs in immunosuppressive indoleamine 2,3‐dioxygenase 1

U. Grohmann, G. Mondanelli, M. L. Belladonna, 2016, Journal of cellular and molecular medicine.

CD 40 Ligand and CTLA-4 Are Reciprocally Regulated in the Th 1 Cell Proliferative Response Sustained by CD 8 Dendritic Cells 1

U. Grohmann, P. Puccetti, R. Bianchi, 2002 .

Modulation Via CD40 Ligation Autocrine IL-12 Is Involved in Dendritic Cell

U. Grohmann, P. Puccetti, R. Bianchi, 1999 .

Dual effect of IL-4 on resistance to systemic gram-negative infection and production of TNF-alpha.

U. Grohmann, P. Puccetti, M. Fioretti, 2000, Cytokine.

The Proteasome Inhibitor Bortezomib Controls Indoleamine 2,3-Dioxygenase 1 Breakdown and Restores Immune Regulation in Autoimmune Diabetes

S. Bicciato, L. Boon, U. Grohmann, 2017, Front. Immunol..

Cinnabarinic acid, an endogenous agonist of type-4 metabotropic glutamate receptor, suppresses experimental autoimmune encephalomyelitis in mice

M. L. Belladonna, C. Volpi, M. Simmaco, 2014, Neuropharmacology.

Exploiting ELIOT for Scaffold-Repurposing Opportunities: TRIM33 a Possible Novel E3 Ligase to Expand the Toolbox for PROTAC Design

Lydia Siragusa, S. Cross, C. Vacca, 2022, International journal of molecular sciences.

CD200 Receptor Engagement Tryptophan Catabolism in Response to the Immunosuppressive Pathway of Murine Plasmacytoid Dendritic Cells Initiate

G. Trinchieri, U. Grohmann, P. Puccetti, 2004 .

Inhibited cell death, NF-kappaB activity and increased IL-10 in TCR-triggered thymocytes of transgenic mice overexpressing the glucocorticoid-induced protein GILZ.

C. Riccardi, C. Vacca, M. Agostini, 2006, International immunopharmacology.

Effects of probiotic administration on immune responses of children and adolescents with type 1 diabetes to a quadrivalent inactivated influenza vaccine

A. Argentiero, U. Grohmann, G. Mondanelli, 2019, Human vaccines & immunotherapeutics.

IL-2 Induces an Altered CD4/CD8 Ratio of Splenic T Lymphocytes from Transgenic Mice Overexpressing the Glucocorticoid-Induced Protein GILZ

C. Riccardi, C. Vacca, L. Cannarile, 2007, Journal of chemotherapy.

Disease Tolerance Mediated by Phosphorylated Indoleamine-2,3 Dioxygenase Confers Resistance to a Primary Fungal Pathogen

P. Puccetti, C. Vacca, L. Romani, 2017, Front. Immunol..

The Pyrazolobenzothiazine Core as a New Chemotype of p38 Alpha Mitogen‐Activated Protein Kinase Inhibitors

M. Loza, J. Brea, S. Laufer, 2015, Chemical biology & drug design.

Aspergillus fumigatus tryptophan metabolic route differently affects host immunity

A. Beauvais, J. Latgé, L. Boon, 2021, Cell reports.

Class IA PI3Ks regulate subcellular and functional dynamics of IDO1

S. Bicciato, K. Okkenhaug, P. Hawkins, 2020, EMBO reports.

Positive allosteric modulation of indoleamine 2,3-dioxygenase 1 restrains neuroinflammation

P. Calabresi, L. Santambrogio, U. Grohmann, 2020, Proceedings of the National Academy of Sciences.

Deficiency of immunoregulatory indoleamine 2,3-dioxygenase 1in juvenile diabetes.

S. Bicciato, D. Fuchs, U. Grohmann, 2018, JCI insight.

A Relay Pathway between Arginine and Tryptophan Metabolism Confers Immunosuppressive Properties on Dendritic Cells

S. Bicciato, L. Santambrogio, L. Zolla, 2017, Immunity.

Stem cells from human amniotic fluid exert immunoregulatory function via secreted indoleamine 2,3-dioxygenase1

U. Grohmann, C. Orabona, M. T. Pallotta, 2015, Journal of cellular and molecular medicine.

Forced IDO1 expression in dendritic cells restores immunoregulatory signalling in autoimmune diabetes

U. Grohmann, G. Mondanelli, M. L. Belladonna, 2014, Journal of cellular and molecular medicine.

Aryl hydrocarbon receptor control of a disease tolerance defence pathway

M. Geffard, S. Bicciato, B. Veyret, 2014, Nature.

Correction: IDO Mediates Tlr9-Driven Protection From Experimental Autoimmune Diabetes

U. Grohmann, P. Puccetti, C. Volpi, 2010, The Journal of Immunology.

IDO Mediates TLR9-Driven Protection from Experimental Autoimmune Diabetes1

U. Grohmann, P. Puccetti, C. Volpi, 2009, The Journal of Immunology.

Experimental Autoimmune Diabetes Ido Mediates Tlr9-driven Protection From

U. Grohmann, P. Puccetti, C. Volpi, 2022 .

SOCS3 drives proteasomal degradation of indoleamine 2,3-dioxygenase (IDO) and antagonizes IDO-dependent tolerogenesis

U. Grohmann, M. L. Belladonna, C. Orabona, 2008, Proceedings of the National Academy of Sciences.

Functional yet Balanced Reactivity to Candida albicans Requires TRIF, MyD88, and IDO-Dependent Inhibition of Rorc1

Francesco Bistoni, Teresa Zelante, Paolo Puccetti, 2007, The Journal of Immunology.

Modulation of tryptophan catabolism by regulatory T cells

U. Grohmann, M. L. Belladonna, C. Orabona, 2003, Nature Immunology.

CTLA-4–Ig regulates tryptophan catabolism in vivo

U. Grohmann, M. L. Belladonna, C. Orabona, 2002, Nature Immunology.

T cell apoptosis by tryptophan catabolism

U. Grohmann, C. Orabona, P. Puccetti, 2002, Cell Death and Differentiation.

T cell apoptosis by kynurenines.

U. Grohmann, C. Orabona, P. Puccetti, 2003, Advances in experimental medicine and biology.

IL‐23 and the Th17 pathway promote inflammation and impair antifungal immune resistance

Francesco Bistoni, Carmela Conte, Teresa Zelante, 2007, European journal of immunology.

SARS-CoV2 infection impairs the metabolism and redox function of cellular glutathione

G. Cruciani, C. Vacca, A. Mencacci, 2021, Redox Biology.

Positive Regulatory Role of IL-12 in Macrophages and Modulation by IFN-γ1

Ciriana Orabona, Paolo Puccetti, Carmine Vacca, 2001, The Journal of Immunology.

Toward the identification of a tolerogenic signature in IDO-competent dendritic cells.

Katia Perruccio, Silvio Bicciato, Ciriana Orabona, 2006, Blood.

Functional expression of indoleamine 2,3-dioxygenase by murine CD8α+ dendritic cells

D. Keskin, U. Grohmann, M. L. Belladonna, 2002 .

dendritic cells Toward the identification of a tolerogenic signature in IDO-competent

S. Bicciato, A. Velardi, U. Grohmann, 2012 .

Engagement of Nuclear Coactivator 7 by 3-Hydroxyanthranilic Acid Enhances Activation of Aryl Hydrocarbon Receptor in Immunoregulatory Dendritic Cells

S. Bicciato, U. Grohmann, G. Mondanelli, 2019, Front. Immunol..

Cutting Edge: Autocrine TGF-β Sustains Default Tolerogenesis by IDO-Competent Dendritic Cells1

L. Boon, U. Grohmann, M. L. Belladonna, 2008, The Journal of Immunology.

CTLA-4–Ig Activates Forkhead Transcription Factors and Protects Dendritic Cells from Oxidative Stress in Nonobese Diabetic Mice

U. Grohmann, M. L. Belladonna, C. Orabona, 2004, The Journal of experimental medicine.

CTLA-4-immunoglobulin and indoleamine 2,3-dioxygenase in dominant tolerance

U. Grohmann, M. T. Pallotta, P. Puccetti, 2008 .

Functional Plasticity of Dendritic Cell Subsets as Mediated by CD40 Versus B7 Activation 1

U. Grohmann, C. Orabona, P. Puccetti, 2003, The Journal of Immunology.

Effect of postpartum progesterone levels on receptivity, ovarian response, embryo quality and developement in rabbits

G. Stradaioli, M. Monaci, C. Boiti, 1996 .

Ligand and cytokine dependence of the immunosuppressive pathway of tryptophan catabolism in plasmacytoid dendritic cells.

G. Trinchieri, U. Grohmann, C. Orabona, 2005, International immunology.

Genetic Polymorphisms Affecting IDO1 or IDO2 Activity Differently Associate With Aspergillosis in Humans

V. Napolioni, F. Aversa, A. Velardi, 2019, Front. Immunol..

CD40 Ligation Ablates the Tolerogenic Potential of Lymphoid Dendritic Cells1

U. Grohmann, M. L. Belladonna, P. Puccetti, 2001, The Journal of Immunology.

Endoplasmic reticulum stress and NF‐kB activation in SARS‐CoV‐2 infected cells and their response to antiviral therapy

G. Cruciani, C. Vacca, A. Gioiello, 2021, IUBMB life.

Cutting Edge: Silencing Suppressor of Cytokine Signaling 3 Expression in Dendritic Cells Turns CD28-Ig from Immune Adjuvant to Suppressant1

U. Grohmann, M. L. Belladonna, C. Orabona, 2005, The Journal of Immunology.

Towards the identification of a tolerogenic signature in IDO-competent dendritic cells DAP 12 and IRF-8 regulate tryptophan catabolism

S. Bicciato, A. Velardi, U. Grohmann, 2005 .

Suppressant Cells Turns CD 28-Ig from Immune Adjuvant Cytokine Signaling 3 Expression in Dendritic Cutting Edge : Silencing Suppressor of Paolo Puccetti

U. Grohmann, M. L. Belladonna, C. Orabona, 2005 .

CD28 induces immunostimulatory signals in dendritic cells via CD80 and CD86

Ciriana Orabona, Maria Cristina Fioretti, Paolo Puccetti, 2004, Nature Immunology.

Targeting the Aryl Hydrocarbon Receptor With Indole-3-Aldehyde Protects From Vulvovaginal Candidiasis via the IL-22-IL-18 Cross-Talk

C. Vacca, P. Mosci, L. Romani, 2019, Front. Immunol..

Maesopsin 4-O-beta-D-glucoside, a natural compound isolated from the leaves of Artocarpus tonkinensis, inhibits proliferation and up-regulates HMOX1, SRXN1 and BCAS3 in acute myeloid leukemia.

C. Riccardi, V. Pettorossi, C. Vacca, 2011, Journal of chemotherapy.

and IDO-Dependent Inhibition of Rorc Candida albicans Requires TRIF, MyD88, Functional yet Balanced Reactivity to

L. Boon, P. Puccetti, A. Luca, 2013 .

Rorc and IDO-Dependent Inhibition of Requires TRIF , MyD 88 , Candida albicans Functional yet Balanced Reactivity to

L. Boon, P. Puccetti, A. Luca, 2007 .

Maesopsin 4-O-beta-D-glucoside, a natural compound isolated from the leaves of Artocarpus tonkinensis, inhibits proliferation and up-regulates HMOX1, SRXN1 and BCAS3 in acute myeloid leukemia.

V. Pettorossi, C. Vacca, A. Liberati, 2011, Journal of chemotherapy.