Y. Nagai

发表

Reduced Surface Expression of TLR4 by a V254I Point Mutation Accounts for the Low Lipopolysaccharide Responder Phenotype of BALB/c B Cells

Y. Ikeda, H. Tsukamoto, K. Fukudome, 2013, The Journal of Immunology.

Innate recognition of lipopolysaccharide by Toll-like receptor 4/MD-2 and RP105/MD-1

Yoshinori Nagai, Hirotaka Ogata, Y. Nagai, 2000, Journal of endotoxin research.

MD-2, a Molecule that Confers Lipopolysaccharide Responsiveness on Toll-like Receptor 4

Yoshinori Nagai, Hirotaka Ogata, K. Fukudome, 1999, The Journal of experimental medicine.

Glycyrrhetinic acid inhibits contact hypersensitivity induced by trichophytin via dectin‐1

Tomoya Nakamura, K. Takatsu, M. Yasoshima, 2016, Experimental dermatology.

Analysis of Trichophyton antigen-induced contact hypersensitivity in mouse.

Tomoya Nakamura, J. Hatta, K. Takatsu, 2012, Journal of dermatological science.

Inhibition of antibody production in vivo by pre-stimulation of Toll-like receptor 4 before antigen priming is caused by defective B-cell priming and not impairment in antigen presentation.

K. Takatsu, H. Tsukamoto, K. Fukudome, 2013, International immunology.

Identification of FOXP3-negative regulatory T-like (CD4(+)CD25(+)CD127(low)) cells in patients with immune dysregulation, polyendocrinopathy, enteropathy, X-linked syndrome.

H. Kanegane, H. Ochs, I. Kobayashi, 2011, Clinical immunology.

Isoliquiritigenin is a potent inhibitor of NLRP3 inflammasome activation and diet‐induced adipose tissue inflammation

K. Tsuneyama, K. Takatsu, H. Hayashi, 2014, Journal of leukocyte biology.

Isoliquiritigenin Attenuates Adipose Tissue Inflammation in vitro and Adipose Tissue Fibrosis through Inhibition of Innate Immune Responses in Mice

K. Takatsu, Y. Ishii, Y. Nagai, 2016, Scientific Reports.

The Radioprotective 105/MD-1 Complex Contributes to Diet-Induced Obesity and Adipose Tissue Inflammation

S. Akira, K. Tsuneyama, Tomoya Nakamura, 2012, Diabetes.

A subset of cerebrovascular pericytes originates from mature macrophages in the very early phase of vascular development in CNS

M. Shibuya, I. Komuro, S. Niida, 2017, Scientific Reports.

Isoliquiritigenin: A Unique Component That Attenuates Adipose Tissue Inflammation and Fibrosis by Targeting the Innate Immune Sensors

Y. Nagai, Yasuharu Watanabe, Hiroe Honda, 2017 .

Allergic diseases: From bench to clinic - Contribution of the discovery of interleukin-5.

M. Satoh, K. Takatsu, M. Koike, 2017, Cytokine.

CD206+ M2-like macrophages regulate systemic glucose metabolism by inhibiting proliferation of adipocyte progenitors

K. Tsuneyama, J. Imura, K. Takatsu, 2017, Nature Communications.

Potential Therapeutic Natural Products for the Treatment of Obesity-Associated Chronic Inflammation by Targeting TLRs and Inflammasomes

K. Takatsu, Y. Nagai, Yasuharu Watanabe, 2016 .

Bofutsushosan improves gut barrier function with a bloom of Akkermansia muciniphila and improves glucose metabolism in mice with diet-induced obesity

A. Nawaz, K. Tobe, I. Usui, 2020, Scientific Reports.

The TLR family protein RP105/MD-1 complex

K. Takatsu, Y. Nagai, Yasuharu Watanabe, 2013, Adipocyte.

NF-κB is dispensable for normal lymphocyte development in bone marrow but required for protection of progenitors from TNFα

S. Ghosh, H. Igarashi, Y. Baba, 2006 .

NF-jB is dispensable for normal lymphocyte development in bone marrow but required for protection of progenitors from TNFa

S. Ghosh, H. Igarashi, Y. Baba, 2006 .

Prolonged activation of IL-5-producing ILC2 causes pulmonary arterial hypertrophy.

K. Tsuneyama, S. Nakae, K. Takatsu, 2017, JCI insight.

Bone Marrow Lacks a Transplantable Progenitor for Smooth Muscle Type α‐Actin–Expressing Cells

J. Tsai, Y. Nagai, Y. Kawakami, 2006 .

Identification of Innate IL-5–Producing Cells and Their Role in Lung Eosinophil Regulation and Antitumor Immunity

K. Tsuneyama, K. Takatsu, S. Takaki, 2012, The Journal of Immunology.

IL-6 blocks a discrete early step in lymphopoiesis.

Y. Baba, K. Coggeshall, Y. Nagai, 2005, Blood.

Bidirectional crosstalk between neutrophils and adipocytes promotes adipose tissue inflammation

I. Takasaki, K. Takatsu, M. Arita, 2019, FASEB journal : official publication of the Federation of American Societies for Experimental Biology.

Shigella protein IpaH ( 9 . 8 ) is secreted from bacteria within mammalian cells and transported to the nucleus

Hirotaka, K. Fukase, Y. Nagai, 2002 .

Increased production of intestinal immunoglobulins in Syntenin-1-deficient mice.

Taketoshi Yoshida, T. Miyawaki, K. Takatsu, 2015, Immunobiology.

Essential role of MD-2 in B-cell responses to lipopolysaccharide and Toll-like receptor 4 distribution

Y. Nagai, K. Miyake, S. Akashi, 2002, Journal of endotoxin research.

Mouse Peritoneal Macrophages Toll-Like Receptor 4-MD2 Complex on Lipopolysaccharide Signaling Via the Cutting Edge : Cell Surface Expression and

K. Takeda, Y. Nagai, K. Miyake, 2000 .

The Toll-like Receptor Protein Rp105 Regulates Lipopolysaccharide Signaling in B Cells

K. Rajewsky, A. Tarakhovsky, Y. Nagai, 2000, The Journal of experimental medicine.

Inflammatory responses increase secretion of MD-1 protein.

K. Takatsu, S. Haga, M. Ozaki, 2016, International immunology.

The RP105/MD-1 complex is indispensable for TLR4/MD-2-dependent proliferation and IgM-secreting plasma cell differentiation of marginal zone B cells.

K. Takatsu, S. Ohta, Y. Nagai, 2012, International immunology.

Serum soluble MD-1 levels increase with disease progression in autoimmune prone MRL(lpr/lpr) mice.

K. Tsuneyama, K. Takatsu, Y. Nagai, 2012, Molecular immunology.

Tonic B cell activation by Radioprotective105/MD-1 promotes disease progression in MRL/lpr mice.

S. Akira, H. Kiyono, Y. Nagai, 2008, International immunology.

Differential requirements of MyD88 and TRIF pathways in TLR4-mediated immune responses in murine B cells.

K. Takatsu, Y. Nagai, Y. Hirai, 2015, Immunology letters.

TLR9 ligation during herpes infection Lymphoid precursors are directed to produce dendritic cells as a result of

M. Farrar, K. Garrett, Rosana Pelayo, 2013 .

Toll-like receptor 7 cooperates with IL-4 in activated B cells through antigen receptor or CD38 and induces class switch recombination and IgG1 production.

S. Akira, T. Kaisho, K. Takatsu, 2009, Molecular immunology.

Lymphoid precursors are directed to produce dendritic cells as a result of TLR9 ligation during herpes infection.

M. Farrar, K. Garrett, Rosana Pelayo, 2008, Blood.

Regulation and Antitumor Immunity and Their Role in Lung Eosinophil Producing Cells - Identification of Innate IL-5

K. Tsuneyama, K. Takatsu, S. Takaki, 2011 .

The Impact of Low-Viscosity Soluble Dietary Fibers on Intestinal Microenvironment and Experimental Colitis: A Possible Preventive Application of Alpha-Cyclodextrin in Intestinal Inflammation.

Y. Tabuchi, S. Ikushiro, Y. Nagai, 2022, Molecular nutrition & food research.

Roles of Macrophages in Advanced Liver Fibrosis, Identified Using a Newly Established Mouse Model of Diet-Induced Non-Alcoholic Steatohepatitis

Y. Tabuchi, K. Kasai, K. Takatsu, 2022, International journal of molecular sciences.

Essential role of MD-2 in LPS responsiveness and TLR4 distribution

S. Akira, T. Kitamura, Y. Iwakura, 2002, Nature Immunology.

Fetal Lymphoid Progenitors Become Restricted to B-1 Fates Coincident with IL-7Rα Expression

K. Takatsu, Y. Nagai, T. Kouro, 2016, PloS one.

Funiculosin variants and phosphorylated derivatives promote innate immune responses via the Toll-like receptor 4/myeloid differentiation factor-2 complex

T. Hirokawa, Toshiyuki Shimizu, K. Takatsu, 2017, The Journal of Biological Chemistry.

Cutting Edge: Cell Surface Expression and Lipopolysaccharide Signaling Via the Toll-Like Receptor 4-MD-2 Complex on Mouse Peritoneal Macrophages1

K. Takeda, Y. Nagai, K. Miyake, 2000, The Journal of Immunology.

Toll-like receptors on hematopoietic progenitor cells stimulate innate immune system replenishment.

S. Akira, K. Garrett, K. Takatsu, 2006, Immunity.

Lipopolysaccharide Interaction with Cell Surface Toll-like Receptor 4-MD-2

K. Fukase, Y. Nagai, K. Miyake, 2003, The Journal of experimental medicine.

Lipid A antagonist, lipid IVa, is distinct from lipid A in interaction with Toll-like receptor 4 (TLR4)-MD-2 and ligand-induced TLR4 oligomerization.

Makiko Kobayashi, K. Fukase, Y. Nagai, 2004, International immunology.

Human MD-2 confers on mouse Toll-like receptor 4 species-specific lipopolysaccharide recognition.

K. Fukase, Y. Nagai, K. Miyake, 2001, International immunology.

The Radioprotective 105/MD-1 Complex Links TLR2 and TLR4/MD-2 in Antibody Response to Microbial Membranes1

S. Akira, T. Kaisho, M. Matsumoto, 2005, The Journal of Immunology.

Regulatory Mechanisms for Adipose Tissue M1 and M2 Macrophages in Diet-Induced Obese Mice

Isao Usui, Yoshinori Nagai, Kazuyuki Tobe, 2009, Diabetes.

Interleukin 5 in the link between the innate and acquired immune response.

K. Takatsu, Y. Nagai, T. Kouro, 2009, Advances in immunology.

Role of the Immune System in Obesity-Associated Inflammation and Insulin Resistance

K. Takatsu, Y. Nagai, 2014 .

Requirement for MD-1 in cell surface expression of RP105/CD180 and B-cell responsiveness to lipopolysaccharide.

Y. Iwakura, Y. Nagai, K. Miyake, 2002, Blood.

HIF-1α in Myeloid Cells Promotes Adipose Tissue Remodeling Toward Insulin Resistance

K. Tsuneyama, J. Imura, K. Takatsu, 2016, Diabetes.

Effect of soluble oat fiber on intestinal microenvironment and TNBS-induced colitis.

Y. Tabuchi, S. Ikushiro, Y. Nagai, 2023, Food & function.

Life before the pre-B cell receptor checkpoint: specification and commitment of primitive lymphoid progenitors in adult bone marrow.

Rosana Pelayo, Y. Nagai, P. Kincade, 2006, Seminars in immunology.

Dok-1 and Dok-2 are negative regulators of lipopolysaccharide-induced signaling

Y. Iwakura, H. Karasuyama, Y. Nagai, 2005, The Journal of experimental medicine.

Immunohistochemical localization of a GnRH-like peptide in the brain of the cephalopod spear-squid, Loligo bleekeri.

Y. Nagai, Y. Oka, M. Amano, 2008, General and comparative endocrinology.

Deficiency of Nicotinamide Mononucleotide Adenylyltransferase 3 (Nmnat3) Causes Hemolytic Anemia by Altering the Glycolytic Flow in Mature Erythrocytes*

K. Takatsu, K. Tobe, Y. Nagai, 2014, The Journal of Biological Chemistry.

Glycolytic Flow in Mature Erythrocytes Hemolytic Anemia by Altering the Adenylyltransferase 3 ( Nmnat 3 ) Causes Deficiency of Nicotinamide Mononucleotide Metabolism

K. Takatsu, K. Tobe, Y. Nagai, 2014 .

Betulin Attenuates TGF-β1- and PGE2-Mediated Inhibition of NK Cell Activity to Suppress Tumor Progression and Metastasis in Mice.

N. Nakajima, K. Takatsu, Y. Nagai, 2022, Biological & pharmaceutical bulletin.

Activation and Regulation of the Pattern Recognition Receptors in Obesity-Induced Adipose Tissue Inflammation and Insulin Resistance

K. Takatsu, Y. Nagai, Yasuharu Watanabe, 2013, Nutrients.

A protein associated with Toll-like receptor (TLR) 4 (PRAT4A) is required for TLR-dependent immune responses

K. Takatsu, Y. Nagai, K. Miyake, 2007, The Journal of experimental medicine.

Regulatory Roles of B Cells in Allergy and Inflammation

K. Takatsu, Y. Nagai, M. Ikutani, 2011 .

Tracing the first waves of lymphopoiesis in mice

Y. Nagai, P. Kincade, J. Hirose, 2006, Development.

Impact of Vancomycin Treatment and Gut Microbiota on Bile Acid Metabolism and the Development of Non-Alcoholic Steatohepatitis in Mice

K. Kasai, K. Takatsu, K. Tobe, 2023, International journal of molecular sciences.

A subset of cerebrovascular pericytes originates from mature macrophages in the very early phase of vascular development in CNS

M. Shibuya, I. Komuro, S. Niida, 2017, Scientific Reports.

Inflammation-induced endothelial cell-derived extracellular vesicles modulate the cellular status of pericytes

S. Niida, K. Takatsu, Ting-Ting Huang, 2015, Scientific Reports.

Regulatory roles for CD14 and phosphatidylinositol in the signaling via toll-like receptor 4-MD-2.

T. Kirikae, K. Fukudome, Y. Nagai, 2000, Biochemical and biophysical research communications.

Adipose tissue hypoxia induces inflammatory M1 polarity of macrophages in an HIF-1α-dependent and HIF-1α-independent manner in obese mice

K. Tsuneyama, K. Takatsu, K. Tobe, 2013, Diabetologia.

CD19 regulates innate immunity by the toll-like receptor RP105 signaling in B lymphocytes.

S. Akira, M. Fujimoto, K. Takeda, 2003, Blood.

Glycyrrhizin and isoliquiritigenin suppress the LPS sensor Toll‐like receptor 4/MD‐2 complex signaling in a different manner

K. Takatsu, H. Hayashi, Y. Nagai, 2012, Journal of leukocyte biology.

Deletion of SIRT1 in myeloid cells impairs glucose metabolism with enhancing inflammatory response to adipose tissue hypoxia

K. Tsuneyama, K. Takatsu, K. Tobe, 2016, Diabetology International.

Telmisartan improves insulin resistance and modulates adipose tissue macrophage polarization in high-fat-fed mice.

K. Tsuneyama, Y. Tabuchi, I. Takasaki, 2011, Endocrinology.

The innate immune receptor RP105 promotes metabolic syndrome by altering gut microbiota composition and intestinal barrier function.

K. Kasai, Y. Nagai, Yukihiro Furusawa, 2023, Biochemical and biophysical research communications.

Response to Microbial Membranes Links TLR2 and TLR4/MD-2 in Antibody The Radioprotective 105/MD-1 Complex

S. Akira, T. Kaisho, M. Matsumoto, 2005 .

Isoliquiritigenin attenuates adipose tissue inflammation and metabolic syndrome by modifying gut bacteria composition in mice.

Y. Tabuchi, K. Takatsu, S. Ikushiro, 2022, Molecular nutrition & food research.

Effect of Wheat-Derived Arabinoxylan on the Gut Microbiota Composition and Colonic Regulatory T Cells

Y. Tabuchi, S. Ikushiro, Y. Nagai, 2023, Molecules.

Bone marrow lacks a transplantable progenitor for smooth muscle type alpha-actin-expressing cells.

Y. Nagai, Y. Kawakami, P. Kincade, 2006, Stem Cells.

Isoxanthohumol improves obesity and glucose metabolism via inhibiting intestinal lipid absorption with a bloom of Akkermansia muciniphila in mice

A. Nawaz, S. Softic, Y. Nagai, 2023, bioRxiv.

in B lymphocytes CD19 regulates innate immunity by the toll-like receptor RP105 signaling

S. Akira, M. Fujimoto, K. Takeda, 2013 .

Eplerenone prevented obesity-induced inflammasome activation and glucose intolerance.

K. Takatsu, D. Koya, T. Sasaoka, 2017, The Journal of endocrinology.

Potential roles for soluble MD-1 in disease progression of autoimmune prone MRLlpr/lpr mice (171.2)

K. Tsuneyama, K. Takatsu, Y. Nagai, 2012, The Journal of Immunology.

Effect of Oral Administration of Polyethylene Glycol 400 on Gut Microbiota Composition and Diet-Induced Obesity in Mice

Y. Tabuchi, S. Ikushiro, Y. Nagai, 2023, Microorganisms.