Gaoyun Hu

发表

Fluorofenidone protects mice from lethal endotoxemia through the inhibition of TNF-alpha and IL-1beta release.

L. Tao, Yanyun Xie, Yiting Tang, 2010, International immunopharmacology.

Fluorofenidone Attenuates TGF-&bgr;1–Induced Lung Fibroblast Activation via Restoring the Expression of Caveolin-1

L. Tao, Gaoyun Hu, Cheng Song, 2015, Shock.

Fluorofenidone Attenuates Bleomycin-Induced Pulmonary Inflammation and Fibrosis in Mice Via Restoring Caveolin 1 Expression and Inhibiting Mitogen-Activated Protein Kinase Signaling Pathway

L. Tao, Chengping Hu, Zhang-zhe Peng, 2012, Shock.

In vitro metabolic characterization of orbitazine, a novel derivative of the PAC-1 anticancer agent.

Gaoyun Hu, Yanfen Chen, Zeneng Cheng, 2020, The Journal of pharmacy and pharmacology.

Fluorofenidone Attenuates Tubulointerstitial Fibrosis by Inhibiting TGF-β1-Induced Fibroblast Activation

L. Tao, Xiao-guang Fu, Linghao Wang, 2011, American Journal of Nephrology.

Synthesis and structure–activity relationships of pyrazolo‐[3,4‐b]pyridine derivatives as adenosine 5'‐monophosphate‐activated protein kinase activators

Qianbin Li, Gaoyun Hu, Shengjie Sun, 2019, Archiv der Pharmazie.

The Protective Effect of Fluorofenidone against Cyclosporine A-Induced Nephrotoxicity

L. Tao, Yanyun Xie, Qianbin Li, 2019, Kidney and Blood Pressure Research.

Fluorofenidone attenuates interleukin‐1β production by interacting with NLRP3 inflammasome in unilateral ureteral obstruction

L. Tao, Yanyun Xie, Yiting Tang, 2018, Nephrology.

The Protective Mechanism of Fluorofenidone in Renal Interstitial Inflammation and Fibrosis

L. Tao, Yanyun Xie, Yiting Tang, 2015, The American journal of the medical sciences.

Mefunidone Attenuates Tubulointerstitial Fibrosis in a Rat Model of Unilateral Ureteral Obstruction

L. Tao, Qiongjing Yuan, Zhang-zhe Peng, 2015, PloS one.

Discovery of 1-(4-((3-(4-methylpiperazin-1-yl)propyl)amino)benzyl)-5-(trifluoromethyl)pyridin-2(1H)-one, an orally active multi-target agent for the treatment of diabetic nephropathy.

L. Tao, Qianbin Li, Dejian Jiang, 2018, Bioorganic & medicinal chemistry letters.

Identification of selective homeodomain interacting protein kinase 2 inhibitors, a potential treatment for renal fibrosis.

L. Tao, Qianbin Li, Zhang-zhe Peng, 2022, Bioorganic chemistry.

Fluorofenidone attenuates renal fibrosis by inhibiting the mtROS-NLRP3 pathway in a murine model of folic acid nephropathy.

L. Tao, Yanyun Xie, Zhang-zhe Peng, 2020, Biochemical and biophysical research communications.

Identification of the human liver cytochrome P450 isoenzymes responsible for the 5-methylhydroxylation of the novel anti-fibrotic drug AKF-PD

Gaoyun Hu, Zeneng Cheng, Xiaoai He, 2011, Xenobiotica; the fate of foreign compounds in biological systems.

The antihepatic fibrotic effects of fluorofenidone via MAPK signalling pathways

B. Liu, L. Tao, Gaoyun Hu, 2013, European journal of clinical investigation.

Protective Effect of Fluorofenidone Against Acute Lung Injury Through Suppressing the MAPK/NF-κB Pathway

L. Tao, Yanyun Xie, Qianbin Li, 2021, Frontiers in Pharmacology.

Fluorofenidone Offers Improved Renoprotection at Early Interventions during the Course of Diabetic Nephropathy in db/db Mice via Multiple Pathways

Ling Huang, L. Tao, D. Tang, 2014, PloS one.

Binding pocket-based design, synthesis and biological evaluation of novel selective BRD4-BD1 inhibitors.

Qianbin Li, Gaoyun Hu, Zutao Yu, 2019, Bioorganic & medicinal chemistry.

Fluorofenidone protects against acute kidney injury

L. Tao, Yanyun Xie, Qianbin Li, 2019, FASEB journal : official publication of the Federation of American Societies for Experimental Biology.

Mefunidone Ameliorates Bleomycin-Induced Pulmonary Fibrosis in Mice

Fan Zhang, L. Tao, Zhang-zhe Peng, 2021, Frontiers in Pharmacology.

Targeted degradation of CD147 proteins in melanoma.

Zhe Zhou, Qianbin Li, Gaoyun Hu, 2020, Bioorganic chemistry (Print).

Mefunidone ameliorates diabetic kidney disease in STZ and db/db mice

L. Tao, Zhang-zhe Peng, Gaoyun Hu, 2020, FASEB journal : official publication of the Federation of American Societies for Experimental Biology.

Design, Synthesis and Anti-fibrosis Activity Study of N1-Substituted Phenylhydroquinolinone Derivatives

B. Liu, L. Tao, Qianbin Li, 2012, Molecules.

Soluble guanylate cyclase stimulators and activators: Where are we, where to go?

Jingqing Yang, Qianbin Li, Gaoyun Hu, 2019, Mini reviews in medicinal chemistry.

Novel potent 2,5-pyrrolidinedione peptidomimetics as aminopeptidase N inhibitors. Design, synthesis and activity evaluation.

Qianbin Li, Gaoyun Hu, H. Fang, 2012, Bioorganic & medicinal chemistry letters.

Novel pyrazolo[3,4‐b]pyridine derivatives: Synthesis, structure–activity relationship studies, and regulation of the AMPK/70S6K pathway

Qianbin Li, Dejian Jiang, Gaoyun Hu, 2022, Archiv der Pharmazie.

Synthesis, Pharmacokinetics, and Pharmacodynamics Studies of Valsartan Peptide Derivatives

Qianbin Li, Gaoyun Hu, Yuan‐jian Li, 2012, Archiv der Pharmazie.

Protective effects of mefunidone on ischemia-reperfusion injury/Folic acid-induced acute kidney injury

L. Tao, Yanyun Xie, Zhang-zhe Peng, 2022, Frontiers in Pharmacology.

Dual inhibitors of ASK1 and PDK1 kinases: Design, synthesis, molecular docking and mechanism studies of N-benzyl pyridine-2-one containing derivatives as anti-fibrotic agents.

Qianbin Li, Gaoyun Hu, Yuanyuan Cao, 2022, European journal of medicinal chemistry.

Synthesis and vasodilator effects of rutaecarpine analogues which might be involved transient receptor potential vanilloid subfamily, member 1 (TRPV1).

Gaoyun Hu, Y. Xie, Yuan‐jian Li, 2009, Bioorganic & medicinal chemistry.

Discovery of Novel Pyrazolo[3,4-b] pyridine Derivatives with Dual Activities of Vascular Remodeling Inhibition and Vasodilation for the Treatment of Pulmonary Arterial Hypertension.

Qinglian Liu, Lijun Li, Qianbin Li, 2020, Journal of medicinal chemistry.

Synthesis, anti-lung cancer activity and molecular docking study of 3-methylene-2-oxoindoline-5-carboxamide derivatives

Qianbin Li, Gaoyun Hu, Meng Lv, 2017, Medicinal Chemistry Research.

The RAF-MEK-ERK pathway: targeting ERK to overcome obstacles to effective cancer therapy.

Qianbin Li, Gaoyun Hu, Zutao Yu, 2015, Future medicinal chemistry.

Design, Synthesis and Antifibrotic Activities of Carbohydrate- Modified 1-(Substituted aryl)-5-trifluoromethyl-2(1H) Pyridones

L. Tao, Q. Hou, Gaoyun Hu, 2012, Molecules.

Fluorofenidone attenuates pulmonary inflammation and fibrosis via inhibiting the activation of NALP3 inflammasome and IL‐1β/IL‐1R1/MyD88/NF‐κB pathway

Jian Zhang, L. Tao, Gaoyun Hu, 2016, Journal of cellular and molecular medicine.

Drug repurposing and rediscovery: Design, synthesis and preliminary biological evaluation of 1-arylamino-3-aryloxypropan-2-ols as anti-melanoma agents.

Qianbin Li, Gaoyun Hu, Zhuo Chen, 2020, Bioorganic & medicinal chemistry.

Cost-effectiveness Analysis of Pembrolizumab Plus Axitinib Versus Sunitinib in First-line Advanced Renal Cell Carcinoma in China

Gaoyun Hu, Chongqing Tan, X. Wan, 2019, Clinical Drug Investigation.

Multistep Virtual Screening Based Identification of Homeodomain-Interacting Protein Kinase 2 Inhibitors: An Opportunity for Treating Chronic Kidney Disease

Qianbin Li, Gaoyun Hu, Yuanyuan Cao, 2021, Chemometrics and Intelligent Laboratory Systems.

Mefunidone ameliorates renal inflammation and tubulointerstitial fibrosis via suppression of IKKβ phosphorylation.

L. Tao, Yiting Tang, Qiongjing Yuan, 2016, The international journal of biochemistry & cell biology.

Fluorofenidone inhibits macrophage IL-1β production by suppressing inflammasome activity.

L. Tao, Gaoyun Hu, Juan Tang, 2015, International immunopharmacology.

Therapeutic strategies of diabetic nephropathy: recent progress and future perspectives.

Qianbin Li, Gaoyun Hu, Meng Lv, 2015, Drug discovery today.

Synthesis, Pharmacophores, and Mechanism Study of Pyridin‐2(1H)‐one Derivatives as Regulators of Translation Initiation Factor 3A

Qianbin Li, Gaoyun Hu, Zhaoqian Liu, 2013, Archiv der Pharmazie.

An emerging strategy for targeted therapy of pulmonary arterial hypertension: vasodilation plus vascular remodeling inhibition.

Qianbin Li, Gaoyun Hu, Zhuo Chen, 2022, Drug discovery today.

Pulmonary artery smooth muscle cell phenotypic switching: A key event in the early stage of pulmonary artery hypertension.

Qianbin Li, Gaoyun Hu, Yuanyuan Cao, 2023, Drug discovery today.

Recent advances in the development of HIPK2 inhibitors as anti-renal fibrosis agents.

Qianbin Li, Gaoyun Hu, Zhuo Chen, 2023, Future medicinal chemistry.

Discovery of Ureido-Based Apcin Analogues as Cdc20-specific Inhibitors against Cancer

Qianbin Li, Gaoyun Hu, Yiqin He, 2023, Pharmaceuticals.

A Novel PDK1/MEK Dual Inhibitor Induces Cytoprotective Autophagy via the PDK1/Akt Signaling Pathway in Non-Small Cell Lung Cancer

Qianbin Li, Gaoyun Hu, Zutao Yu, 2023, Pharmaceuticals.

A novel dual MEK/PDK1 inhibitor 9za retards the cell cycle at G0/G1 phase and induces mitochondrial apoptosis in non-small cell lung cancer cells

Fengying Huang, Qianbin Li, Gaoyun Hu, 2020, PeerJ.

Dual inhibitors of RAF-MEK-ERK and PI3K-PDK1-AKT pathways: Design, synthesis and preliminary anticancer activity studies of 3-substituted-5-(phenylamino) indolone derivatives.

Xiaoping Yang, Qianbin Li, Gaoyun Hu, 2019, Bioorganic & medicinal chemistry.

Synthesis, preliminary biological evaluation and 3D-QSAR study of novel 1,5-disubstituted-2(1H)-pyridone derivatives as potential anti-lung cancer agents

Qianbin Li, Gaoyun Hu, Chuo Chen, 2016 .

Fluorofenidone protects against acute liver failure in mice by regulating MKK4/JNK pathway.

L. Tao, Yanyun Xie, Gaoyun Hu, 2023, Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie.

Discovery of a Dual Tubulin Polymerization and Cell Division Cycle 20 Homologue Inhibitor via Structural Modification on Apcin.

Qianbin Li, Gaoyun Hu, F. Huang, 2020, Journal of medicinal chemistry.

9za plays cytotoxic and proapoptotic roles and induces cytoprotective autophagy through the PDK1/Akt/mTOR axis in non‐small‐cell lung cancer

Fengying Huang, Gaoyun Hu, Zhaoqian Liu, 2019, Journal of cellular physiology.

Discovery of 1-(4-((3-(4-methylpiperazin-1-yl)propyl)amino)benzyl)-5-(trifluoromethyl)pyridin-2(1H)-one, an orally active multi-target agent for the treatment of diabetic nephropathy.

L. Tao, Qianbin Li, Dejian Jiang, 2018, Bioorganic & medicinal chemistry letters.

Fluorofenidone Attenuates Tubulointerstitial Fibrosis by Inhibiting TGF-β1-Induced Fibroblast Activation

L. Tao, Xiao-guang Fu, Linghao Wang, 2011, American Journal of Nephrology.

Inhibition of Hsp110-STAT3 interaction in endothelial cells alleviates vascular remodeling in hypoxic pulmonary arterial Hypertension model

Qianbin Li, Gaoyun Hu, Liqing Hu, 2023, Respiratory Research.

Inhibitors of 11β-Hydroxylase (CYP11B1) for Treating Diseases Related to Excess Cortisol.

Qianbin Li, Gaoyun Hu, Guishan Tan, 2016, Current medicinal chemistry.