A. Ayala

C. Coopersmith, R. Hotchkiss, Katherine C. Chang, 2009, FASEB journal : official publication of the Federation of American Societies for Experimental Biology.

Effects of prolactin and metoclopramide on macrophage cytokine gene expression in late sepsis.

I. Chaudry, M. Wichmann, A. Ayala, 1997, Cytokine.

Females in proestrus state maintain splenic immune functions and tolerate sepsis better than males.

I. Chaudry, M. Wichmann, A. Ayala, 1997, Critical care medicine.

MyD88-dependent expansion of an immature GR-1+CD11b+ population induces T cell suppression and Th2 polarization in sepsis

L. Moldawer, M. Delano, Kindra M Kelly-Scumpia, 2007, The Journal of experimental medicine.

SHOCK AND HEMORRHAGE: AN OVERVIEW OF ANIMAL MODELS

Alfred Ayala, C. Chung, A. Ayala, 2005, Shock.

Rat and Mouse Models of Hypovolemic-Traumatic Shock

I. Chaudry, J. Hauptman, Ping Wang, 1993 .

Herpes Virus Entry Mediator (HVEM): A Novel Potential Mediator of Trauma-Induced Immunosuppression.

D. Heffernan, S. Monaghan, A. Ayala, 2020, The Journal of surgical research.

TAT-SNAP-23 treatment inhibits the priming of neutrophil functions contributing to shock and/or sepsis-induced extra-pulmonary acute lung injury

S. Uriarte, K. Mcleish, C. Chung, 2015, Innate immunity.

A divergent response of innate regulatory T-cells to sepsis in humans: circulating invariant natural killer T-cells are preserved.

D. Heffernan, S. Monaghan, W. Cioffi, 2014, Human immunology.

Effects of alpha- and beta-adrenergic agonists on Trypanosoma cruzi interaction with host cells.

A. Ayala, M. Connelly, F. Kierszenbaum, 1988, The Journal of parasitology.

Regulatory T cell populations in sepsis and trauma

C. Chung, A. Ayala, F. Venet, 2008, Journal of leukocyte biology.

Differential induction of apoptosis in lymphoid tissues during sepsis: variation in onset, frequency, and the nature of the mediators.

I. Chaudry, A. Ayala, D. Lehman, 1996, Blood.

Role of protein kinase C in cyclic AMP-mediated suppression of T-lymphocyte activation following burn injury.

I. Chaudry, K. Bland, W. Cioffi, 1999, Biochimica et biophysica acta.

Program Cell Death Receptor-1-Mediated Invariant Natural Killer T-Cell Control of Peritoneal Macrophage Modulates Survival in Neonatal Sepsis

D. Heffernan, A. Ayala, E. Fallon, 2017, Front. Immunol..

Immune dysfunction following trauma-haemorrhage: influence of gender and age.

I. Chaudry, K. Bland, W. Cioffi, 2000, Cytokine.

Testosterone: the culprit for producing splenocyte immune depression after trauma hemorrhage.

I. Chaudry, K. Bland, W. Cioffi, 1998, American journal of physiology. Cell physiology.

Testosterone and/or low estradiol: normally required but harmful immunologically for males after trauma-hemorrhage.

I. Chaudry, K. Bland, W. Cioffi, 1997, The Journal of trauma.

Testosterone receptor blockade after hemorrhage in males. Restoration of the depressed immune functions and improved survival following subsequent sepsis.

I. Chaudry, M. Wichmann, W. Cioffi, 1997, Archives of surgery.

Male sex steroids are responsible for depressing macrophage immune function after trauma-hemorrhage.

I. Chaudry, M. Wichmann, A. Ayala, 1997, American journal of physiology. Cell physiology.

Mechanism of immunosuppression in males following trauma-hemorrhage. Critical role of testosterone.

I. Chaudry, M. Wichmann, A. Ayala, 1996, Archives of surgery.

Depressed splenic function after hemorrhage results from gastrointestinal tract stimulation of hepatic-mediator release. Correction with portacaval shunt.

I. Chaudry, M. W. Flye, A. Ayala, 1996, Archives of surgery.

Leukocyte apoptosis and its significance in sepsis and shock

C. Chung, A. Ayala, Joanne L. Lomas-Neira, 2005, Journal of leukocyte biology.

Contribution of anti-inflammatory/immune suppressive processes to the pathology of sepsis.

C. Chung, A. Ayala, Mario Perl, 2006, Frontiers in bioscience : a journal and virtual library.

The effects of p-chloromercuriphenylsulfonic acid on Trypanosoma cruzi infection of mammalian host cells in vitro.

A. Ayala, F. Kierszenbaum, 1987, Molecular and biochemical parasitology.

Down-Regulation of the Immune Response

H. Simms, C. Chung, A. Ayala, 2003 .

Heat Shock Proteins in the Regulation of the Apoptotic Response

I. Chaudry, C. Chung, A. Ayala, 1998 .

Overview of the Molecular Pathways and Mediators of Sepsis

Brittany A. Potz, A. Ayala, Tristen T. Chun, 2017 .

Effects of hydroxyethyl starch after trauma-hemorrhagic shock: restoration of macrophage integrity and prevention of increased circulating interleukin-6 levels.

Alfred Ayala, I. Chaudry, J. Schmand, 1995, Critical care medicine.

RNA interference as a potential therapeutic treatment for inflammation associated lung injury.

C. Chung, A. Ayala, Joanne L. Lomas-Neira, 2008, International journal of clinical and experimental medicine.

Loss of signal transducer and activator of transduction 4 or 6 signaling contributes to immune cell morbidity and mortality in sepsis

W. Cioffi, C. Chung, A. Ayala, 2005, Intensive Care Medicine.

Negative Immune Checkpoint Protein, VISTA, Regulates the CD4+ Treg Population During Sepsis Progression to Promote Acute Sepsis Recovery and Survival

C. Chung, A. Ayala, Yaping Chen, 2022, Frontiers in Immunology.

The new normal: immunomodulatory agents against sepsis immune suppression.

R. Hotchkiss, A. Ayala, Noelle A. Hutchins, 2014, Trends in molecular medicine.

Kupffer cells protect liver sinusoidal endothelial cells from Fas-dependent apoptosis in sepsis by down-regulating gp130.

C. Chung, A. Ayala, Noelle A. Hutchins, 2013, The American journal of pathology.

CELL INJURY , REPAIR , AGING , AND APOPTOSIS Kupffer Cells Protect Liver Sinusoidal Endothelial Cells from Fas-Dependent Apoptosis in Sepsis by Down-Regulating gp 130

C. Chung, A. Ayala, Noelle A. Hutchins, 2013 .

Failure to normalize lymphopenia following trauma is associated with increased mortality, independent of the leukocytosis pattern

J. Machan, D. Heffernan, S. Monaghan, 2012, Critical Care.

Role of Programmed Cell Death in the Immunopathogenesis of Sepsis.

C. Chung, A. Ayala, Mario Perl, 2007, Drug discovery today. Disease mechanisms.

Treatment with GITR agonistic antibody corrects adaptive immune dysfunction in sepsis.

L. Moldawer, M. Delano, Kindra M Kelly-Scumpia, 2007, Blood.

CD8+ T cells promote inflammation and apoptosis in the liver after sepsis: role of Fas-FasL.

C. Chung, A. Ayala, T. Salazar-Mather, 2007, The American journal of pathology.

The apoptotic pathway as a therapeutic target in sepsis.

C. Chung, A. Ayala, R. Swan, 2007, Current drug targets.

SOCS-1 is a central mediator of steroid-increased thymocyte apoptosis and decreased survival following sepsis

L. Doughty, C. Chung, A. Ayala, 2007, Apoptosis.

Mechanisms of immune resolution.

C. Chung, A. Ayala, G. Y. Song, 2003, Critical care medicine.

Another piece of the pathobiological puzzle in the response to trauma.

A. Ayala, 2000, Critical care medicine.

Rodent Models of Endotoxemia and Sepsis

I. Chaudry, J. Hauptman, Ping Wang, 1993 .

Enhanced immune responses in females, as opposed to decreased responses in males following haemorrhagic shock and resuscitation.

I. Chaudry, M. Wichmann, A. Ayala, 1996, Cytokine.

TRAUMA-HEMORRHAGE CAUSES PROLONGED DEPRESSION IN CELLULAR IMMUNITY

I. Chaudry, A. Ayala, R. Zellweger, 1995, Shock.

Effects of trauma, duration of hypotension, and resuscitation regimen on cellular immunity after hemorrhagic shock

I. Chaudry, J. Schmand, A. Ayala, 1994, Critical care medicine.

EFFECT OF GENDER AND SEX HORMONES ON IMMUNE RESPONSES FOLLOWING SHOCK

I. Chaudry, A. Ayala, M. Angele, 2000, Shock.

B and T lymphocyte attenuator expression on CD4+ T-cells associates with sepsis and subsequent infections in ICU patients

D. Heffernan, S. Monaghan, C. Chung, 2013, Critical Care.

Part II: Minimum Quality Threshold in Preclinical Sepsis Studies (MQTiPSS) for Types of Infections and Organ Dysfunction Endpoints.

C. Deutschman, M. Bauer, J. Cavaillon, 2019, Shock.

A Novel Role for Programmed Cell Death Receptor Ligand-1 in Sepsis-Induced Intestinal Dysfunction

D. Heffernan, S. Monaghan, C. Chung, 2016, Molecular medicine.

Fate and effects of adult bone marrow cells in lungs of normoxic and hyperoxic newborn mice.

J. Padbury, A. Ayala, Q. Mao, 2009, American journal of respiratory cell and molecular biology.

Do female sex steroids adversely or beneficially affect the depressed immune responses in males after trauma-hemorrhage?

I. Chaudry, K. Bland, W. Cioffi, 2000, Archives of surgery.

Trauma-induced suppression of antigen presentation and expression of major histocompatibility class II antigen complex in leukocytes.

I. Chaudry, A. Ayala, W. Ertel, 1996, Shock.

Chloroquine attenuates hemorrhagic shock-induced suppression of Kupffer cell antigen presentation and major histocompatibility complex class II antigen expression through blockade of tumor necrosis factor and prostaglandin release.

I. Chaudry, A. Ayala, W. Ertel, 1991, Blood.

Prolonged immunodepression after trauma and hemorrhagic shock.

I. Chaudry, A. Ayala, Y. X. Xu, 1998, The Journal of trauma.

Mechanism of the beneficial effects of pentoxifylline on hepatocellular function after trauma hemorrhage and resuscitation.

Z. Ba, I. Chaudry, A. Ayala, 1992, Surgery.

Ibuprofen restores cellular immunity and decreases susceptibility to sepsis following hemorrhage.

I. Chaudry, D. Meldrum, A. Ayala, 1992, The Journal of surgical research.

Effect of naloxone on immune responses after hemorrhagic shock

I. Chaudry, M. Wichmann, A. Ayala, 2000, Critical care medicine.

Biological significance of elevated TNF levels: in vivo administration of monoclonal antibody against tnf following haemorrhage shock increases the capacity of macrophages to release TNF while restoring immunoresponsiveness.

I. Chaudry, A. Ayala, W. Ertel, 1994, Cytokine.

Modulation of macrophage membrane phospholipids by n-3 polyunsaturated fatty acids increases interleukin 1 release and prevents suppression of cellular immunity following hemorrhagic shock.

I. Chaudry, A. Ayala, W. Ertel, 1993, Archives of surgery.

Enhanced susceptibility to sepsis after simple hemorrhage. Depression of Fc and C3b receptor-mediated phagocytosis.

I. Chaudry, A. Ayala, M. Perrin, 1990, Archives of surgery.

ROLE OF KUPFFER CELLS IN INTERLEUKIN‐6 RELEASE FOLLOWING TRAUMA‐HEMORRHAGE AND RESUSCITATION

Z. Ba, Ping Wang, A. Ayala, 1994, Shock.

l-Arginine restores splenocyte functions after trauma and hemorrhage potentially by improving splenic blood flow.

I. Chaudry, W. Cioffi, A. Ayala, 1999, American journal of physiology. Cell physiology.

L-Arginine restores splenocyte functions after trauma and hemorrhage potentially by improving splenic blood flow.

I. Chaudry, W. Cioffi, A. Ayala, 1999, The American journal of physiology.

Measurement of circulating blood volume in vivo after trauma-hemorrhage and hemodilution.

Z. Ba, I. Chaudry, A. Ayala, 1994, The American journal of physiology.

Immunopathology and Infectious Diseases Plasmacytoid Dendritic Cells Control Lung Inflammation and Monocyte Recruitment in Indirect Acute Lung Injury in Mice

C. Chung, A. Ayala, F. Venet, 2010 .

l-Arginine attenuates trauma-hemorrhage-induced liver injury

I. Chaudry, F. Fitzal, Ping Wang, 2000, Critical care medicine.

[Contribution of soft tissue trauma and/or bone fracture to immune suppression after hemorrhagic shock in the animal experiment].

I. Chaudry, M. Wichmann, A. Ayala, 1998, Der Unfallchirurg.

Immune depression in polymicrobial sepsis: The role of necrotic (injured) tissue and endotoxin

I. Chaudry, C. Chung, A. Ayala, 2000, Critical care medicine.

Protective effects of preheparinization on the microvasculature during and after hemorrhagic shock.

I. Chaudry, A. Ayala, Mian Zhou, 1992, The Journal of trauma.

L-arginine: a unique amino acid for restoring the depressed macrophage functions after trauma-hemorrhage.

I. Chaudry, K. Bland, W. Cioffi, 1999, The Journal of trauma.

The role of neutrophils in producing hepatocellular dysfunction during the hyperdynamic stage of sepsis in rats.

I. Chaudry, P. Wang, A. Ayala, 1997, The Journal of surgical research.

Sepsis-induced changes in macrophage co-stimulatory molecule expression: CD86 as a regulator of anti-inflammatory IL-10 response.

C. Chung, A. Ayala, Joanne L. Lomas-Neira, 2004, Surgical infections.

Soluble programmed cell death receptor-1 (sPD-1): a potential biomarker with anti-inflammatory properties in human and experimental acute respiratory distress syndrome (ARDS)

W. Fairbrother, D. Heffernan, S. Monaghan, 2016, Journal of Translational Medicine.

The release of transforming growth factor-beta following haemorrhage: its role as a mediator of host immunosuppression.

I. Chaudry, D. Meldrum, A. Ayala, 1993, Immunology.

Anti-inflammatory mechanisms of sepsis.

S. Monaghan, A. Ayala, Nicholas J. Shubin, 2011, Contributions to microbiology.

Sepsis induces an early increased spontaneous release of hepatocellular stimulatory factor (interleukin-6) by Kupffer cells in both endotoxin tolerant and intolerant mice.

I. Chaudry, A. Ayala, P. Wang, 1992, The Journal of surgical research.

Increased circulating regulatory T cells (CD4+CD25+CD127−) contribute to lymphocyte anergy in septic shock patients

C. Chung, A. Ayala, F. Poitevin, 2009, Intensive Care Medicine.

Hypoxemia in the absence of blood loss upregulates iNOS expression and activity in macrophages.

Nadia Smail, William G Cioffi, Alfred Ayala, 1999, American journal of physiology. Cell physiology.

Trauma-hemorrhage induces increased thymic apoptosis while decreasing IL-3 release and increasing GM-CSF.

I. Chaudry, M. Wichmann, W. Cioffi, 1997, The Journal of surgical research.

Tumor necrosis factor-alpha produces hepatocellular dysfunction despite normal cardiac output and hepatic microcirculation.

Z. Ba, I. Chaudry, A. Ayala, 1993, The American journal of physiology.

Decreased monocyte human leukocyte antigen-DR expression after severe burn injury: Correlation with severity and secondary septic shock

A. Ayala, S. Tissot, F. Venet, 2007, Critical care medicine.

Divergent Effects of Activated Neutrophils on Inflammation, Kupffer Cell/Splenocyte Activation, and Lung Injury Following Blunt Chest Trauma

M. Huber-Lang, A. Ayala, M. Bachem, 2012, Shock.

Insight into the mechanism by which metoclopramide improves immune functions after trauma-hemorrhage.

I. Chaudry, K. Bland, W. Cioffi, 2000, American journal of physiology. Cell physiology.

Prolactin inhibits the increased cytokine gene expression in Kupffer cells following haemorrhage.

I. Chaudry, A. Ayala, R. Zellweger, 1996, Cytokine.

Paracrine Suppression of Apoptosis by Cytokine-Stimulated Neutrophils Involves Divergent Regulation Of NF-&Kgr;B, Bcl-XL, and Bak

H. Simms, A. Ayala, P. Grutkoski, 2002, Shock.

Fas-induced pulmonary apoptosis and inflammation during indirect acute lung injury.

W. Cioffi, C. Chung, A. Ayala, 2007, American journal of respiratory and critical care medicine.

Effect of Exposure Period and Algal Concentration on the Frequency of Infection of Aposymbiotic Ciliates by Symbiotic Algae from Paramecium bursaria

A. Ayala, D. Weis, 1979 .

The launch of the international journal of clinical and experimental medicine.

Ping Wang, Dengshun Wang, Alfred Ayala, 2008, International journal of clinical and experimental medicine.

The Role of Hepatic Invariant NKT Cells in Systemic/Local Inflammation and Mortality during Polymicrobial Septic Shock1

C. Chung, A. Ayala, F. Venet, 2009, The Journal of Immunology.

Sex steroids regulate pro- and anti-inflammatory cytokine release by macrophages after trauma-hemorrhage.

I. Chaudry, K. Bland, W. Cioffi, 1999, The American journal of physiology.

Minimum Quality Threshold in Pre-Clinical Sepsis Studies (Mqtipss): An International Expert Consensus Initiative for Improvement of Animal Modeling in Sepsis

M. Singer, C. Deutschman, M. Bauer, 2018, Shock.

Sex-specific p38 MAP kinase activation following trauma-hemorrhage: involvement of testosterone and estradiol.

I. Chaudry, F. Schildberg, A. Ayala, 2003, American journal of physiology. Endocrinology and metabolism.

p38 MAPK mediates renal tubular cell TNF-α production and TNF-α-dependent apoptosis during simulated ischemia

K. Meldrum, D. Meldrum, A. Ayala, 2001 .

MAPK p38 antagonism as a novel method of inhibiting lymphoid immune suppression in polymicrobial sepsis.

I. Chaudry, A. Ayala, C. Chung, 2001, American journal of physiology. Cell physiology.

Immune suppression in polymicrobial sepsis: differential regulation of Th1 and Th2 responses by p38 MAPK.

I. Chaudry, C. Chung, A. Ayala, 2000, The Journal of surgical research.

Does endotoxin play a major role in inducing the depression of macrophage function during polymicrobial sepsis?

I. Chaudry, A. Ayala, Z. Deol, 1995, Archives of surgery.

Check Point Inhibitors and Their Role in Immunosuppression in Sepsis.

D. Heffernan, S. Monaghan, A. Ayala, 2020, Critical care clinics.

A Novel Role for Programmed Cell Death Receptor Ligand-1 ( PD-L 1 ) in Sepsis-Induced Intestinal Dysfunction Running title : PD-L 1 in Septic Gut Dysfunction

D. Heffernan, S. Monaghan, C. Chung, 2016 .

A PEPTIDE-BASED CHECKPOINT IMMUNOMODULATOR ALLEVIATES IMMUNE DYSFUNCTION IN MURINE POLYMICROBIAL SEPSIS

R. Hotchkiss, James Pannucci, V. Kotraiah, 2020, Shock.

Defective macrophage antigen presentation following haemorrhage is associated with the loss of MHC class II (Ia) antigens.

I. Chaudry, A. Ayala, M. Perrin, 1990, Immunology.

Emerging therapeutic targets for sepsis

D. Heffernan, S. Monaghan, A. Ayala, 2021, Expert opinion on therapeutic targets.

Lymphocyte integrin expression differences between SIRS and sepsis patients

D. Heffernan, S. Monaghan, A. Ayala, 2017, Irish Journal of Medical Science (1971 -).

Immune consequences of hypovolemic shock and resuscitation

I. Chaudry, A. Ayala, 1993 .

Recombinant human activated protein C inhibits integrin-mediated neutrophil migration.

A. Ayala, J. McGrath, G. Elphick, 2009, Blood.

Programmed Cell Death Receptor Ligand 1 Modulates the Regulatory T Cells’ Capacity to Repress Shock/Sepsis–Induced Indirect Acute Lung Injury by Recruiting Phosphatase Src Homology Region 2 Domain-Containing Phosphatase 1

C. Chung, A. Ayala, Joanne L. Lomas-Neira, 2015, Shock.

The Effect of Puromycin and Cycloheximide on the Infection of Algae‐Free Paramecium bursaria by Symbiotic Chlorellae1

A. Ayala, D. Weis, 1987 .

Double-hit mouse model of cigarette smoke priming for acute lung injury.

A. Ayala, Zhengke Wang, Joanne L. Lomas-Neira, 2017, American journal of physiology. Lung cellular and molecular physiology.

Sepsis-Induced Potentiation of Peritoneal Macrophage Migration Is Mitigated by Programmed Cell Death Receptor-1 Gene Deficiency

C. Chung, A. Ayala, G. Elphick, 2013, Journal of Innate Immunity.

Premise for Standardized Sepsis Models.

C. Deutschman, C. Coopersmith, I. Chaudry, 2019, Shock.

Minimum Quality Threshold in Pre-Clinical Sepsis Studies (MQTiPSS): an international expert consensus initiative for improvement of animal modeling in sepsis

M. Singer, C. Deutschman, M. Bauer, 2018, Infection.

Dehydroepiandrosterone: an inexpensive steroid hormone that decreases the mortality due to sepsis following trauma-induced hemorrhage.

I. Chaudry, K. Bland, W. Cioffi, 1998, Archives of surgery.

Flutamide: a novel agent for restoring the depressed cell-mediated immunity following soft-tissue trauma and hemorrhagic shock.

I. Chaudry, M. Wichmann, W. Cioffi, 1997, Shock.

Differential Alterations in Cardiovascular Responses During the Progression of Polymicrobial Sepsis in the Mouse

I. Chaudry, Ping Wang, C. Chung, 2002, Shock.

HEMORRHAGE INDUCES A REDUCTION IN THE CAPACITY OF MACROPHAGES TO MOBILIZE INTRACELLULAR CALCIUM SECONDARY TO FORMYL‐METHIONYL‐LEUCYL‐PHENYLALANINE STIMULATION: ASSOCIATION WITH ALTERATIONS IN CELL SURFACE Fc RECEPTOR EXPRESSION AND INCREASED PROSTAGLANDIN RELEASE

I. Chaudry, A. Ayala, 1994, Shock.

The Acute Immunological Response to Blood Transfusion Is Influenced by Polymicrobial Sepsis

M. Delano, A. Cuenca, P. Efron, 2012, Shock.

Trauma-hemorrhage delays wound healing potentially by increasing pro-inflammatory cytokines at the wound site.

I. Chaudry, K. Bland, W. Cioffi, 1999, Surgery.

Insights into the mechanisms of defective antigen presentation after hemorrhage.

I. Chaudry, A. Ayala, W. Ertel, 1991, Surgery.

Inhibition of neutrophil Apoptosis after severe trauma is NFκβ dependent. Discussion

A. Ayala, W. Cheadle, P. Bankey, 2000 .

Soluble programmed cell death receptor-1 (sPD-1): a potential biomarker with anti-inflammatory properties in human and experimental acute respiratory distress syndrome (ARDS)

W. Fairbrother, D. Heffernan, S. Monaghan, 2016, Journal of Translational Medicine.

IMMUNE DYSFUNCTION IN MURINE POLYMICROBIAL SEPSIS: MEDIATORS, MACROPHAGES, LYMPHOCYTES AND APOPTOSIS

I. Chaudry, A. Ayala, 1996, Shock.

Evolution of an immune suppressive macrophage phenotype as a product of P38 MAPK activation in polymicrobial sepsis.

I. Chaudry, C. Chung, A. Ayala, 2001, Shock.

Polymicrobial sepsis enhances clearance of apoptotic immune cells by splenic macrophages.

W. Cioffi, C. Chung, A. Ayala, 2007, Surgery.

Changes in the process of alternative RNA splicing results in soluble B and T lymphocyte attenuator with biological and clinical implications in critical illness

M. Levy, Kamil J. Cygan, W. Fairbrother, 2018, Molecular Medicine.

Pre-mRNA processing entropy in a mouse model of trauma

J. Machan, S. Monaghan, A. Ayala, 2021, bioRxiv.

Programmed Death 1 Expression as a Marker for Immune and Physiological Dysfunction in the Critically Ill Surgical Patient

D. Heffernan, S. Monaghan, R. Thakkar, 2012, Shock.

CD28 homodimer interface mimetic peptide acts as a preventive and therapeutic agent in models of severe bacterial sepsis and gram-negative bacterial peritonitis.

W. Blackwelder, A. Chahin, S. Opal, 2015, The Journal of infectious diseases.

Improved Antimicrobial Host Defense in Mice following Poly-(1,6)-β-d-Glucopyranosyl-(1,3)-β-d-Glucopyranose Glucan Treatment by a Gender-Dependent Immune Mechanism

A. Ayala, J. Reichner, S. Gregory, 2011, Clinical and Vaccine Immunology.

Group 2 Innate Lymphoid Cells (ILC2s) Are Key Mediators of the Inflammatory Response in Polymicrobial Sepsis.

D. Heffernan, W. Cioffi, C. Chung, 2018, The American journal of pathology.

The Role and Source of Tumor Necrosis Factor-&agr; in Hemorrhage-Induced Priming for Septic Lung Injury

C. Chung, A. Ayala, Joanne L. Lomas-Neira, 2012, Shock.

Hepatocellular dysfunction persists during early sepsis despite increased volume of crystalloid resuscitation.

Z. Ba, I. Chaudry, A. Ayala, 1991, The Journal of trauma.

Mechanism of the beneficial effects of ATP-MgCl2 following trauma-hemorrhage and resuscitation: downregulation of inflammatory cytokine (TNF, IL-6) release.

Z. Ba, I. Chaudry, A. Ayala, 1992, The Journal of surgical research.

ATP-MgCl2 restores renal microcirculation following trauma and severe hemorrhage.

Z. Ba, I. Chaudry, A. Ayala, 1992, Canadian journal of physiology and pharmacology.

TNFalpha-induced suppression of PMN apoptosis is mediated through interleukin-8 production.

S. Leuenroth, H. Simms, A. Ayala, 2000, Shock.

Anti-TNF monoclonal antibodies prevent haemorrhage-induced suppression of Kupffer cell antigen presentation and MHC class II antigen expression.

I. Chaudry, A. Ayala, W. Ertel, 1991, Immunology.

The geriatric cytokine response to trauma: time to consider a new threshold.

D. Heffernan, S. Monaghan, W. Cioffi, 2014, Surgical infections.

Correction to: Minimum Quality Threshold in Pre-Clinical Sepsis Studies (MQTiPSS): an international expert consensus initiative for improvement of animal modeling in sepsis

M. Singer, C. Deutschman, M. Bauer, 2018, Infection.

Application of single cell multiomics points to changes in chromatin accessibility near calcitonin receptor like receptor and a possible role for adrenomedullin in the post-shock lung

S. Monaghan, C. Chung, A. Ayala, 2023, Frontiers in Medicine.

Dehydroepiandrosterone restores immune function following trauma-haemorrhage by a direct effect on T lymphocytes.

I. Chaudry, K. Bland, W. Cioffi, 1999, Cytokine.

Regulation of Trypanosoma cruzi infectivity by alpha- and beta-adrenergic agonists: desensitization produced by prolonged treatments or increasing agonist concentrations

A. Ayala, F. Kierszenbaum, 1990, Parasitology.

Chloroquine inhibits macrophage tumour necrosis factor-alpha mRNA transcription.

I. Chaudry, A. Ayala, W. Ertel, 1993, Immunology.

A novel role for programmed cell death receptor ligand 2 in sepsis-induced hepatic dysfunction.

C. Chung, A. Ayala, A. Matoso, 2019, American journal of physiology. Gastrointestinal and liver physiology.

AGGRESSIVE FLUID RESUSCITATION FOLLOWING INTESTINAL ISCHEMIA‐REPERFUSION IN IMMATURE RATS PREVENTS METABOLIC DERANGEMENTS AND DOWN REGULATES INTERLEUKIN‐6 RELEASE

L. M. Cobb, I. Chaudry, A. Ayala, 1994, Shock.

Lymphocyte HVEM/BTLA co-expression after critical illness demonstrates severity indiscriminate upregulation, impacting critical illness-induced immunosuppression

D. Heffernan, C. Chung, A. Ayala, 2023, Frontiers in Medicine.

Depressed osteoblast activity and increased osteocyte necrosis after closed bone fracture and hemorrhagic shock.

I. Chaudry, M. Wichmann, S. Arnoczky, 1996, The Journal of trauma.

Alpha-defensin 1 (human neutrophil protein 1) as an antichemotactic agent for human polymorphonuclear leukocytes.

Y. Lim, H. Simms, A. Ayala, 2003, Antimicrobial agents and chemotherapy.

Septic mucosal intraepithelial lymphoid immune suppression: role for nitric oxide not interleukin-10 or transforming growth factor-beta.

I. Chaudry, C. Chung, A. Ayala, 2000, The Journal of trauma.

Polymicrobial sepsis selectively activates peritoneal but not alveolar macrophages to release inflammatory mediators (interleukins-1 and -6 and tumor necrosis factor).

I. Chaudry, A. Ayala, W. Ertel, 1992, Circulatory shock.

Survival and Pulmonary Injury After Neonatal Sepsis: PD1/PDL1's Contributions to Mouse and Human Immunopathology

D. Heffernan, C. Chung, A. Ayala, 2021, Frontiers in Immunology.

Increased inducible apoptosis in CD4+ T lymphocytes during polymicrobial sepsis is mediated by Fas ligand and not endotoxin

Chung, Redmond, I. Chaudry, 1999, Immunology.

Hemorrhage decreases macrophage inflammatory protein 2 and interleukin-6 release: a possible mechanism for increased wound infection.

I. Chaudry, K. Bland, W. Cioffi, 1999, Annals of surgery.

Changes in the process of alternative RNA splicing results in soluble B and T lymphocyte attenuator with biological and clinical implications in critical illness

M. Levy, Kamil J. Cygan, W. Fairbrother, 2018, Molecular Medicine.

Does Fas ligand or endotoxin contribute to thymic apoptosis during polymicrobial sepsis?

I. Chaudry, C. Chung, A. Ayala, 1999, Shock.

Melatonin Administration Attenuates Depressed Immune Functions after Trauma-Hemorrhage

I. Chaudry, M. Wichmann, A. Ayala, 1996 .

Minimum Quality Threshold in Pre-Clinical Sepsis Studies (Mqtipss): An International Expert Consensus Initiative for Improvement of Animal Modeling in Sepsis

M. Singer, C. Deutschman, C. Coopersmith, 2018, Shock.

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M. Singer, C. Deutschman, M. Bauer, 2018, Intensive Care Medicine Experimental.

Chemically induced hypotension increases PGE2 release and depresses macrophage antigen presentation.

I. Chaudry, A. Ayala, W. Ertel, 1993, The American journal of physiology.

Gender dimorphism in trauma-hemorrhage-induced thymocyte apoptosis.

I. Chaudry, K. Bland, W. Cioffi, 1999, Shock.

Dehydroepiandrosterone: an inexpensive steroid hormone that decreases the mortality due to sepsis following trauma-induced hemorrhage.

I. Chaudry, K. Bland, W. Cioffi, 1998, Archives of surgery.

The role of bacterial translocation on Kupffer cell immune function following hemorrhage.

I. Chaudry, A. Ayala, R. Zellweger, 1995, Progress in clinical and biological research.

Eicosanoids regulate tumor necrosis factor synthesis after hemorrhage in vitro and in vivo.

I. Chaudry, A. Ayala, W. Ertel, 1991, The Journal of trauma.

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