Xin Du

发表

Forward Genetic Analysis of TLR Pathways

B. Beutler, K. Hoebe, P. Georgel, 2005 .

Lps2 and Signal Transduction in Sepsis: At the Intersection of Host Responses to Bacteria and Viruses

B. Beutler, K. Hoebe, P. Georgel, 2003, Scandinavian journal of infectious diseases.

Lps2: a new locus required for responses to lipopolysaccharide, revealed by germline mutagenesis and phenotypic screening.

B. Beutler, K. Hoebe, Xin Du, 2003, Journal of endotoxin research.

ENU-induced phenovariance in mice: inferences from 587 mutations

Daniel L. Popkin, Zhengfan Jiang, B. Beutler, 2012, BMC Research Notes.

The Unc93b1 mutation 3d disrupts exogenous antigen presentation and signaling via Toll-like receptors 3, 7 and 9

S. Grinstein, L. Tarantino, T. Wiltshire, 2006, Nature Immunology.

Herpes Simplex Virus Encephalitis in Human UNC-93B Deficiency

J. Casanova, C. Picard, F. Geissmann, 2006, Science.

Hypersusceptibility to vesicular stomatitis virus infection in Dicer1-deficient mice is due to impaired miR24 and miR93 expression.

Ryan Cook, Young Jun Kang, Qing Jing, 2007, Immunity.

Identification of Toll-like receptor 4 (Tlr4) as the sole conduit for LPS signal transduction: genetic and evolutionary studies.

B. Beutler, Xin Du, A. Poltorak, 2001 .

Crystallin γB-I4F Mutant Protein Binds to α-Crystallin and Affects Lens Transparency*

J. Yates, B. Beutler, Xin Du, 2005, Journal of Biological Chemistry.

The role of Vldlr in intraretinal angiogenesis in mice.

B. Beutler, Xin Du, Haiquan Liu, 2011, Investigative ophthalmology & visual science.

A Toll-Like Receptor 2-Responsive Lipid Effector Pathway Protects Mammals against Skin Infections with Gram-Positive Bacteria

V. Nizet, Zhengfan Jiang, B. Beutler, 2005, Infection and Immunity.

MyD88 signaling in nonhematopoietic cells protects mice against induced colitis by regulating specific EGF receptor ligands

C. Blobel, B. Beutler, Xiaohong Li, 2010, Proceedings of the National Academy of Sciences.

Enhanced sensitivity to DSS colitis caused by a hypomorphic Mbtps1 mutation disrupting the ATF6-driven unfolded protein response

D. Brenner, B. Beutler, Xiaohong Li, 2009, Proceedings of the National Academy of Sciences.

Hypopigmentation and Maternal-Zygotic Embryonic Lethality Caused by a Hypomorphic Mbtps1 Mutation in Mice

B. Beutler, E. Moresco, Xiaohong Li, 2012, G3: Genes | Genomes | Genetics.

Point mutations in the melanocortin-4 receptor cause variable obesity in mice

M. Justice, B. Beutler, T. Meehan, 2006, Mammalian Genome.

A model for familial exudative vitreoretinopathy caused by LPR5 mutations.

M. Wang, B. Beutler, Catherine Cheng, 2008, Human molecular genetics.

Antagonism between MyD88‐ and TRIF‐dependent signals in B7RP‐1 up‐regulation

Zhengfan Jiang, B. Beutler, K. Hoebe, 2005, European journal of immunology.

An essential role for Rxr alpha in the development of Th2 responses.

B. Beutler, Xin Du, K. Tabeta, 2005, European Journal of Immunology.

A Slfn2 mutation causes lymphoid and myeloid immunodeficiency due to loss of immune cell quiescence

Daniel L. Popkin, S. Akira, O. Takeuchi, 2010, Nature Immunology.

Association of hereditary cataracts in strain guinea-pigs with mutation of the gene for ζ-crystallin

Manuel B. Datiles III, Xin Du, J. Zigler, 1990 .

Mutation of the gastric hydrogen-potassium ATPase alpha subunit causes iron-deficiency anemia in mice.

B. Beutler, P. Krebs, Xin Du, 2011, Blood.

An ENU-induced splice site mutation of mouse Col1a1 causing recessive osteogenesis imperfecta and revealing a novel splicing rescue

K. Ohno, B. Beutler, M. Kaku, 2017, Scientific Reports.

The Mask Mutation Identifies TMPRSS6 as an Essential Suppressor of Hepcidin Gene Expression, Required for Normal Uptake of Dietary Iron.

B. Beutler, Xin Du, E. Beutler, 2007 .

Genetic analysis of innate immunity: identification and function of the TIR adapter proteins.

B. Beutler, K. Hoebe, P. Georgel, 2005, Advances in experimental medicine and biology.

R‐form LPS, the master key to the activation ofTLR4/MD‐2‐positive cells

Zhengfan Jiang, B. Beutler, M. Huber, 2006, European journal of immunology.

The Serine Protease TMPRSS6 Is Required to Sense Iron Deficiency

B. Beutler, E. Moresco, Xin Du, 2008, Science.

CD36 is a sensor of diacylglycerides

Thomas Hartung, T. Hartung, B. Beutler, 2005, Nature.

Diverse gap junctions modulate distinct mechanisms for fiber cell formation during lens development and cataractogenesis

B. Beutler, Catherine Cheng, Xin Du, 2006, Development.

I787 provides signals for c-Kit receptor internalization and functionality that control mast cell survival and development.

P. Rosenstiel, T. Goldmann, B. Beutler, 2010, Blood.

Genetic analysis of host resistance: Toll-like receptor signaling and immunity at large.

Zhengfan Jiang, B. Beutler, K. Hoebe, 2006, Annual review of immunology.

From phenomenon to phenotype and from phenotype to gene: forward genetics and the problem of sepsis.

B. Beutler, K. Hoebe, Xin Du, 2003, The Journal of infectious diseases.

A catechol-O-methyltransferase that is essential for auditory function in mice and humans

G. Koob, A. Roberts, L. Tarantino, 2008, Proceedings of the National Academy of Sciences.

Genetic analysis of innate immunity.

Zhengfan Jiang, B. Beutler, K. Hoebe, 2006, Advances in immunology.

Precis on forward genetics in mice

B. Beutler, Xin Du, Yu Xia, 2007, Nature Immunology.

Velvet, a Dominant Egfr Mutation That Causes Wavy Hair and Defective Eyelid Development in Mice

B. Beutler, K. Hoebe, Xin Du, 2004, Genetics.

CD14 is required for MyD88-independent LPS signaling

Zhengfan Jiang, B. Beutler, M. Huber, 2005, Nature Immunology.

HCFC2 is needed for IRF1- and IRF2-dependent Tlr3 transcription and for survival during viral infections

J. Takahashi, Zhengfan Jiang, B. Beutler, 2017, The Journal of experimental medicine.

A Deep Intronic Mutation in the Ankyrin-1 Gene Causes Diminished Protein Expression Resulting in Hemolytic Anemia in Mice

Xin Du, K. Tabeta, Hua Huang, 2013, G3: Genes, Genomes, Genetics.

The extracellular matrix gene Frem1 is essential for the normal adhesion of the embryonic epidermis.

Martin S. Taylor, Monica J Justice, Ian Smyth, 2004, Proceedings of the National Academy of Sciences of the United States of America.

Toll-like receptors 9 and 3 as essential components of innate immune defense against mouse cytomegalovirus infection.

R. Flavell, B. Beutler, K. Hoebe, 2004, Proceedings of the National Academy of Sciences of the United States of America.

An essential role for Rxrα in the development of Th2 responses

B. Beutler, Xin Du, K. Tabeta, 2005 .

Genetic analysis of innate immunity: TIR adapter proteins in innate and adaptive immune responses.

B. Beutler, K. Hoebe, P. Georgel, 2004, Microbes and infection.

Disruption of copper homeostasis due to a mutation of Atp7a delays the onset of prion disease

E. Masliah, B. Beutler, Xin Du, 2012, Proceedings of the National Academy of Sciences.

Details of Toll-like receptor:adapter interaction revealed by germ-line mutagenesis.

I. Wilson, A. Olson, Zhengfan Jiang, 2006, Proceedings of the National Academy of Sciences of the United States of America.

Analysis of the MCMV resistome by ENU mutagenesis

B. Beutler, K. Hoebe, P. Georgel, 2006, Mammalian Genome.

PanR1, a Dominant Negative Missense Allele of the Gene Encoding TNF-α (Tnf), Does Not Impair Lymphoid Development1

B. Dahiyat, B. Beutler, J. Zalevsky, 2006, The Journal of Immunology.

ENU mutagenesis in mice.

B. Beutler, K. Hoebe, P. Georgel, 2008, Methods in molecular biology.

Characterization of mouse mutants with abnormal RPE cells.

M. Wang, B. Beutler, Xin Du, 2006, Advances in experimental medicine and biology.

Severe retinal degeneration caused by a novel rhodopsin mutation.

J. Flannery, B. Beutler, Xin Du, 2010, Investigative ophthalmology & visual science.

Defective LPS signaling in C3H/HeJ and C57BL/10ScCr mice: mutations in Tlr4 gene.

P. Ricciardi-Castagnoli, B. Beutler, Xin Du, 1998, Science.

Identification of Lps2 as a key transducer of MyD88-independent TIR signalling

Jiahuai Han, B. Beutler, S. O. Kim, 2003, Nature.

How we detect microbes and respond to them: the Toll‐like receptors and their transducers

B. Beutler, K. Hoebe, Xin Du, 2003, Journal of leukocyte biology.

Erratum: Genetic and physical mapping of the Lps locus: Identification of the toll-4 receptor as a candidate gene in the critical region (Blood Cells, Molecules, and Diseases (1998) 24:3 (340-355))

B. Roe, S. Clifton, B. Beutler, 1999 .

Identification of Toll-like receptor 4 (Tlr4) as the sole conduit for LPS signal transduction: genetic and evolutionary studies

B. Beutler, Xin Du, Xin Du, 2001, Journal of endotoxin research.

Three novel mammalian toll-like receptors: gene structure, expression, and evolution.

B. Beutler, Xin Du, A. Poltorak, 2000, European cytokine network.

Endotoxin-mimetic effect of antibodies against Toll-like receptor 4

J. Nattermann, B. Beutler, Xin Du, 2000, Journal of endotoxin research.

Lps2: a new locus required for responses to lipopolysaccharide, revealed by germline mutagenesis and phenotypic screening

B. Beutler, K. Hoebe, Xin Du, 2003 .

Erratum: Analysis of Tlr4-mediated LPS signal transduction in macrophages by mutational modification of the receptor (Blood Cells, Molecules, and Diseases (1999) 25:6 (328-338))

B. Beutler, Xin Du, A. Poltorak, 2000 .