A. Nakashima

发表

Tetrahydrobiopterin biosynthesis in white and brown adipose tissues is enhanced following intraperitoneal administration of bacterial lipopolysaccharide.

K. Fujiwara, K. Mori, Y. Kaneko, 2004, Biochimica et biophysica acta.

Deletion of N‐terminus of human tyrosine hydroxylase type 1 enhances stability of the enzyme in AtT‐20 cells

N. Hayashi, K. Mori, Y. Kaneko, 2005, Journal of neuroscience research.

RNAi of 14-3-3eta protein increases intracellular stability of tyrosine hydroxylase.

N. Hayashi, K. Mori, Y. Kaneko, 2007, Biochemical and biophysical research communications.

Peripheral lipopolysaccharide induces apoptosis in the murine olfactory bulb

Hisahide Takahashi, K. Mori, Y. Kaneko, 2005, Brain Research.

Determination of tetrahydrobiopterin in murine locus coeruleus by HPLC with fluorescence detection.

K. Mori, A. Nakashima, A. Ota, 2001, Brain research. Brain research protocols.

A possible pathophysiological role of tyrosine hydroxylase in Parkinson’s disease suggested by postmortem brain biochemistry: a contribution for the special 70th birthday symposium in honor of Prof. Peter Riederer

H. Nagasaki, K. Mori, Y. Kaneko, 2012, Journal of Neural Transmission.

Peripherally injected lipopolysaccharide induces apoptosis in the subventricular zone of young adult mice

K. Mori, Y. Kaneko, A. Nakashima, 2010, Neuroscience Letters.

The Early Coasting Method during Ovarian Stimulation in Antagonist Protocols with Combined Use of Cabergoline is Useful in Patients with Polycystic Ovary Syndrome

A. Nakashima, 2021, Journal of Reproductive Medicine, Gynaecology & Obstetrics.

Amino Acid Composition of Amniotic Fluid during the Perinatal Period Reflects Mother’s Fat and Carbohydrate Intake

A. Nakashima, Mitsue Sano, Haruna Nagura, 2021, Nutrients.

Exon 3 of tyrosine hydroxylase gene: lack of association with Japanese schizophrenic patients

H. Koga, K. Fujiwara, K. Mori, 2001, Molecular Psychiatry.

Lipopolysaccharide treatment arrests the cell cycle of BV-2 microglial cells in G1 phase and protects them from UV light-induced apoptosis

H. Nagasaki, K. Mori, Y. Kaneko, 2014, Journal of Neural Transmission.

Neuromelanin in Parkinson’s Disease: Tyrosine Hydroxylase and Tyrosinase

K. Wakamatsu, S. Ito, A. Nakashima, 2022, International journal of molecular sciences.

Monoamine Oxidase Inhibitor (MAO-I)-Mediated Neuroprotection for Treating Parkinson’s Disease

A. Nakashima, T. Nagatsu, 2019, NeuroPsychopharmacotherapy.

RESISTANCE TO EXCESSIVE BODYWEIGHT GAIN IN RISPERIDONE‐INJECTED RATS

Hisahide Takahashi, K. Mori, Y. Kaneko, 2005, Clinical and experimental pharmacology & physiology.

Intracellular stability of tyrosine hydroxylase: phosphorylation and proteasomal digestion of the enzyme.

H. Nagasaki, K. Mori, Y. Kaneko, 2013, Advances in pharmacology.

PHARMACOLOGY AND

Akira Nakashima, Akira Ota, Steven A. Thomas, 2006 .

The mutation of two amino acid residues in the N‐terminus of tyrosine hydroxylase (TH) dramatically enhances the catalytic activity in neuroendocrine AtT‐20 cells

K. Fujiwara, K. Mori, Y. Kaneko, 2002, Journal of neurochemistry.

Proteasome-mediated degradation of tyrosine hydroxylase triggered by its phosphorylation: a new question as to the intracellular location at which the degradation occurs

H. Nagasaki, Y. Kaneko, A. Nakashima, 2016, Journal of Neural Transmission.

Aripiprazole increases NAD(P)H–quinone oxidoreductase-1 and heme oxygenase-1 in PC12 cells

H. Nagasaki, K. Mori, Y. Kaneko, 2015, Journal of Neural Transmission.

Risperidone reduces mRNA expression levels of Sulfonylurea Receptor 1 and TASK1 in PC12 cells

K. Mori, Y. Kaneko, A. Nakashima, 2007, Neuroscience Letters.

Microglial Activation in Neuroinflammation: Implications for the Etiology of Neurodegeneration

K. Mori, Y. Kaneko, A. Nakashima, 2012, Neurodegenerative Diseases.

Peripheral administration of lipopolysaccharide enhances the expression of guanosine triphosphate cyclohydrolase I mRNA in murine locus coeruleus

K. Mori, A. Nakashima, A. Ota, 2003, Neuroscience.

Expression of GTP cyclohydrolase I in murine locus ceruleus is enhanced by peripheral administration of lipopolysaccharide

K. Mori, Y. Kaneko, A. Nakashima, 2001, Brain Research.

Dynamics of Transcriptional Events in Stress-Triggered Regulation of Adrenal Catecholamine Biosynthetic Enzymes

A. Nakashima, R. Kvetňanský, B. Nankova, 2002 .

Peripheral injection of risperidone, an atypical antipsychotic, alters the bodyweight gain of rats.

K. Fujiwara, K. Mori, Y. Kaneko, 2003, Clinical and experimental pharmacology & physiology.

Characterization of Hypothalamic MCH Neuron Development in a 3D Differentiation System of Mouse Embryonic Stem Cells

T. Kameyama, H. Nagasaki, Y. Kaneko, 2022, eNeuro.

Effect of peripherally administered lipopolysaccharide (LPS) on GTP cyclohydrolase I, tetrahydrobiopterin and norepinephrine in the locus coeruleus in mice

K. Mori, A. Nakashima, A. Ota, 2007, Stress.

Expression of human tyrosine hydroxylase type I in Escherichia coli as a protease-cleavable fusion protein

K. Mori, A. Nakashima, A. Ota, 1999, Journal of Neural Transmission.

Effects of aripiprazole and clozapine on the treatment of glycolytic carbon in PC12 cells

H. Nagasaki, K. Mori, Y. Kaneko, 2012, Journal of Neural Transmission.

Cytosolic Catechols Inhibit α-Synuclein Aggregation and Facilitate the Formation of Intracellular Soluble Oligomeric Intermediates

D. Lynch, B. Giasson, A. Nakashima, 2006, The Journal of Neuroscience.

Interactions between Egr1 and AP1 factors in regulation of tyrosine hydroxylase transcription.

A. Nakashima, A. Ota, E. Sabban, 2003, Brain research. Molecular brain research.

Effects of dopamine on N-terminus-deleted human tyrosine hydroxylase type 1 expressed in Escherichia coli

K. Mori, A. Nakashima, A. Ota, 1997, Neuroscience Letters.

Positive charge intrinsic to Arg37‐Arg38 is critical for dopamine inhibition of the catalytic activity of human tyrosine hydroxylase type 1

N. Hayashi, K. Mori, Y. Kaneko, 2000, FEBS letters.

Dopamine Inhibition of Human Tyrosine Hydroxylase Type 1 Is Controlled by the Specific Portion in the N‐Terminus of the Enzyme

K. Mori, A. Nakashima, A. Ota, 1999, Journal of neurochemistry.

K. Mori, A. Nakashima, A. Ota, 1998, Comparative biochemistry and physiology. Part B, Biochemistry & molecular biology.

Role of N-terminus of tyrosine hydroxylase in the biosynthesis of catecholamines

N. Hayashi, K. Mori, Y. Kaneko, 2009, Journal of Neural Transmission.

Regulation of oxidative stress in long‐lived lipopolysaccharide‐activated microglia

K. Mori, Y. Kaneko, A. Nakashima, 2012, Clinical and experimental pharmacology & physiology.

Human tyrosine hydroxylase in Parkinson’s disease and in related disorders

Kazuto Kobayashi, A. Nakashima, H. Ichinose, 2018, Journal of Neural Transmission.

Identification by nano-LC-MS/MS of NT5DC2 as a protein binding to tyrosine hydroxylase: Down-regulation of NT5DC2 by siRNA increases catecholamine synthesis in PC12D cells.

H. Nagasaki, Y. Kaneko, A. Nakashima, 2019, Biochemical and biophysical research communications.

Subventricular Zone Under the Neuroinflammatory Stress and Parkinson’s Disease

H. Nagasaki, K. Mori, Y. Kaneko, 2012, Cellular and Molecular Neurobiology.

Lipopolysaccharide extends the lifespan of mouse primary-cultured microglia

K. Mori, Y. Kaneko, A. Nakashima, 2009, Brain Research.

Inhibition of deubiquitinating activity of USP14 decreases tyrosine hydroxylase phosphorylated at Ser19 in PC12D cells.

H. Nagasaki, Y. Kaneko, A. Nakashima, 2016, Biochemical and biophysical research communications.

Effect of peripheral lipopolysaccharide injection on dopamine content in murine anterior olfactory nucleus

K. Fujiwara, K. Mori, Y. Kaneko, 2003, Journal of Neural Transmission.

Effect of lipopolysaccharide on the gene expression of the enzymes involved in tetrahydrobiopterin de novo biosynthesis in murine neuroblastoma cell line N1E-115

K. Mori, A. Nakashima, A. Ota, 1997, Neuroscience Letters.

Serotonin 5-HT2B receptor antagonism is fundamental for protecting PC12 cells exposed to hydrogen peroxide

H. Nagasaki, K. Mori, Y. Kaneko, 2015 .

Peripheral injection of lipopolysaccharide enhances expression of inflammatory cytokines in murine locus coeruleus: possible role of increased norepinephrine turnover

K. Mori, Y. Kaneko, A. Nakashima, 2005, Journal of neurochemistry.

Peripheral injection of risperidone, an atypical antipsychotic, alters the bodyweight gain of rats

K. Fujiwara, K. Mori, Y. Kaneko, 2002 .

Estradiol Stimulates Gene Expression of Norepinephrine Biosynthetic Enzymes in Rat Locus coeruleus

A. Nakashima, M. Rivkin, E. Sabban, 2002, Neuroendocrinology.

Effects of atypical antipsychotics and haloperidol on PC12 cells: only aripiprazole phosphorylates AMP-activated protein kinase

K. Mori, Y. Kaneko, A. Nakashima, 2010, Journal of Neural Transmission.

NT5DC2 affects the phosphorylation of tyrosine hydroxylase regulating its catalytic activity

H. Nagasaki, Y. Kaneko, A. Nakashima, 2020, Journal of Neural Transmission.

The role of tyrosine hydroxylase as a key player in neuromelanin synthesis and the association of neuromelanin with Parkinson’s disease

P. Riederer, K. Wakamatsu, S. Ito, 2023, Journal of Neural Transmission.

Phosphorylation of the N-terminal portion of tyrosine hydroxylase triggers proteasomal digestion of the enzyme.

N. Hayashi, K. Mori, Y. Kaneko, 2011, Biochemical and biophysical research communications.

Aripiprazole increases NADPH level in PC12 cells: the role of NADPH oxidase

H. Nagasaki, Y. Kaneko, A. Nakashima, 2013, Journal of Neural Transmission.

Proteasomal degradation of tyrosine hydroxylase and neurodegeneration

A. Nakashima, 2012, Journal of neurochemistry.

Peripheral Lipopolysaccharide Administration Affects the Olfactory Dopamine System in Mice

K. Mori, Y. Kaneko, A. Nakashima, 2008, Annals of the New York Academy of Sciences.

Long-range axonal projections of transplanted mouse embryonic stem cell-derived hypothalamic neurons into adult mouse brain

T. Kameyama, H. Nagasaki, Y. Kaneko, 2022, PloS one.

EpCAM Is a Surface Marker for Enriching Anterior Pituitary Cells From Human Hypothalamic-Pituitary Organoids

T. Kameyama, H. Arima, H. Nagasaki, 2022, Frontiers in Endocrinology.

Intracellular Stability of Tyrosine Hydroxylase: Phosphorylation and Proteasomal Digestion of the Enzyme

H. Nagasaki, K. Mori, Y. Kaneko, 2014 .

Peripheral injection of risperidone, an atypical antipsychotic, alters the bodyweight gains of rats: reply

K. Fujiwara, K. Mori, A. Nakashima, 2003 .

Proteasome-mediated degradation of tyrosine hydroxylase triggered by its phosphorylation: a new question as to the intracellular location at which the degradation occurs

H. Nagasaki, Y. Kaneko, A. Nakashima, 2016, Journal of Neural Transmission.