I. Saiki

H. Sakurai, M. Choo, I. Saiki, 2005, European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences.

Anti-tumor angiogenesis effect of aminopeptidase inhibitor bestatin against B16-BL6 melanoma cells orthotopically implanted into syngeneic mice.

Yurika Saitoh, Hiroaki Sakurai, Keiichi Koizumi, 2004, Cancer letters.

Aminopeptidase N (APN/CD13) is selectively expressed in vascular endothelial cells and plays multiple roles in angiogenesis.

K. Nishikawa, I. Saiki, K. Koizumi, 2006, Cancer letters.

A derivative of aminopeptidase inhibitor (BE15) has a dual inhibitory effect of invasion and motility on tumor and endothelial cells.

H. Sakurai, I. Saiki, K. Koizumi, 2006, Biological & pharmaceutical bulletin.

Inhibition of tumor invasion and extracellular matrix degradation by ubenimex (bestatin)

I. Saiki, I. Azuma, F. Abe, 2004, Clinical & Experimental Metastasis.

Participation of syndecan 2 in the induction of stress fiber formation in cooperation with integrin alpha5beta1: structural characteristics of heparan sulfate chains with avidity to COOH-terminal heparin-binding domain of fibronectin.

Hiroshi Yamamoto, Y. Nagayasu, I. Saiki, 2000, Experimental cell research.

Analgesic effects of systemic fentanyl on cancer pain are mediated by not only central but also peripheral opioid receptors in mice

I. Saiki, Y. Kuraishi, T. Andoh, 2018, European journal of pharmacology.

Herbal Medicine Goshajinkigan Prevents Paclitaxel-Induced Mechanical Allodynia without Impairing Antitumor Activity of Paclitaxel

I. Saiki, Y. Hayakawa, M. A. Bahar, 2013, Evidence-based complementary and alternative medicine : eCAM.

Inhibition by sulfated chitin derivatives of invasion through extracellular matrix and enzymatic degradation by metastatic melanoma cells.

M. Nakajima, I. Saiki, J. Murata, 1990, Cancer research.

Inhibitory anti-tumor effects of interleukin-4 on Philadelphia chromosome-positive acute lymphocytic leukemia and other hematopoietic malignancies.

T. Miyazaki, I. Saiki, M. Okabe, 1992, Leukemia & lymphoma.

Pharmaceutical evaluation of liquorice before and after roasting in mice

H. Sakurai, I. Saiki, Tomohiro Yamada, 2004, The Journal of pharmacy and pharmacology.

Involvement of TNF-alpha in enhancement of invasion and metastasis of colon 26-L5 carcinoma cells in mice by social isolation stress.

I. Saiki, J. Murata, K. Murakami, 1999, Oncology research.

Absolute Configuration and Antitumor Activity of Myxochelin A Produced by Nonomuraea pusilla TP-A0861†

H. Sakurai, I. Saiki, Y. Igarashi, 2006, The Journal of Antibiotics.

Mediastinal lymph node metastasis model by orthotopic intrapulmonary implantation of Lewis lung carcinoma cells in mice

I. Saiki, T. Misaki, K. Murakami, 1999, British Journal of Cancer.

Androgen receptor negatively influences the expression of chemokine receptors (CXCR4, CCR1) and ligand-mediated migration in prostate cancer DU-145.

H. Fuse, I. Saiki, K. Koizumi, 2006, Oncology reports.

Overexpression of Retinoic Acid Receptor α in Hepatocellular Carcinoma

M. Makuuchi, T. Takayama, I. Saiki, 2003 .

Inhibitory effect of berberine on the mediastinal lymph node metastasis produced by orthotopic implantation of Lewis lung carcinoma.

I. Saiki, K. Murakami, T. Yamaura, 2001, Cancer letters.

Inhibition of angiogenesis and intrahepatic growth of colon cancer by TAC-101.

I. Saiki, K. Murakami, Y. Yamada, 1999, Clinical cancer research : an official journal of the American Association for Cancer Research.

Abrogation of species specificity for activation of tumoricidal properties in macrophages by recombinant mouse or human interferon-gamma encapsulated in liposomes.

I. Fidler, I. Saiki, W. Fogler, 1985, Journal of immunology.

Effect of Hachimijiogan against Renal Dysfunction and Involvement of Hypoxia-Inducible Factor-1α in the Remnant Kidney Model

K. Tsuneyama, H. Sakurai, I. Saiki, 2011, Evidence-based complementary and alternative medicine : eCAM.

VGA1155, a novel binding antagonist of VEGF, inhibits angiogenesis in vitro and in vivo.

T. Yamagishi, S. Nakaike, M. Ono, 2004, Anticancer research.

Solitary lung tumors and their spontaneous metastasis in athymic nude mice orthotopically implanted with human non-small cell lung cancer.

I. Saiki, T. Misaki, K. Murakami, 2000, Neoplasia.

Piperine enhances the efficacy of TRAIL-based therapy for triple-negative breast cancer cells.

I. Saiki, H. Yagita, S. Awale, 2014, Anticancer research.

CXCL16 suppresses liver metastasis of colorectal cancer by promoting TNF-α-induced apoptosis by tumor-associated macrophages

K. Tsuneyama, I. Takasaki, T. Irimura, 2014, BMC Cancer.

Role of the CXCL12/CXCR4 axis in peritoneal carcinomatosis of gastric cancer.

H. Sakurai, I. Saiki, K. Koizumi, 2006, Cancer research.

Role of tyrosine kinase-independent phosphorylation of EGFR with activating mutation in cisplatin-treated lung cancer cells.

Aminullah, H. Sakurai, I. Saiki, 2015, Biochemical and biophysical research communications.

The Prostate 69 : 346 ^ 351 ( 2009 ) SerumActiveHepatocyteGrowth Factor ( AHGF ) in Benign ProstaticDisease and ProstateCancer

Y. Fujiuchi, H. Fuse, I. Saiki, 2009 .

Ethanolic extract of Thevetia peruviana flowers enhances TNF-α and TRAIL-induced apoptosis of human cervical cancer cells via intrinsic and extrinsic pathways.

H. Sakurai, I. Saiki, C. Managit, 2017, Oncology letters.

eNOS and Hsp90 interaction directly correlates with cord formation in human lymphatic endothelial cells.

H. Sakurai, I. Saiki, K. Koizumi, 2011, Lymphatic research and biology.

Inhibitory Effect of Chitin Heparinoids on the Lung Metastasis of B16‐BL6 Melanoma

I. Saiki, J. Murata, I. Azuma, 1989, Japanese journal of cancer research : Gann.

TAC‐101 (4‐[3,5‐bis(trimethylsilyl)benzamido]benzoic acid) Inhibits Spontaneous Mediastinal Lymph Node Metastasis Produced by Orthotopic Implantation of Lewis Lung Carcinoma

I. Saiki, Yuji Yamada, K. Murakami, 1999, Japanese journal of cancer research : Gann.

Characterization of the invasive and metastatic phenotype in human renal cell carcinoma

I. Fidler, S. Naito, J. Price, 1991, Clinical & Experimental Metastasis.

Anti-invasive and metastatic activities of evodiamine.

I. Saiki, M. Ogasawara, T. Matsunaga, 2002, Biological & pharmaceutical bulletin.

Induction of autocrine factor inhibiting cell motility from murine B16–Bl6 melanoma cells by α‐melanocyte stimulating hormone

I. Saiki, J. Murata, Hideomi Watanabe, 1999, International journal of cancer.

Molecular properties of poly(RGD) and its binding capacities to metastatic melanoma cells.

I. Saiki, J. Murata, I. Azuma, 2009, International journal of peptide and protein research.

Role of CX3CL1/Fractalkine in Osteoclast Differentiation and Bone Resorption1

K. Tsuneyama, Y. Takano, H. Sakurai, 2009, The Journal of Immunology.

Differentiation and Bone Resorption Role of CX3CL1/Fractalkine in Osteoclast

K. Tsuneyama, Y. Takano, H. Sakurai, 2009 .

CCL21 promotes the migration and adhesion of highly lymph node metastatic human non-small cell lung cancer Lu-99 in vitro.

H. Sakurai, I. Saiki, K. Koizumi, 2007, Oncology reports.

TAK1‐mediated stress signaling pathways are essential for TNF‐α‐promoted pulmonary metastasis of murine colon cancer cells

H. Sakurai, M. Choo, I. Saiki, 2006, International journal of cancer.

A ginseng saponin metabolite suppresses tumor necrosis factor-α-promoted metastasis by suppressing nuclear factor-κB signaling in murine colon cancer cells

Dong-Hyun Kim, H. Sakurai, M. Choo, 2008 .

Calpain 1 and -2 play opposite roles in cord formation of lymphatic endothelial cells via eNOS regulation

H. Sakurai, I. Saiki, K. Koizumi, 2012, Human Cell.

The inhibition of murine lung metastasis by synthetic polypeptides [poly(arg-gly-asp) and poly(tyr-ile-gly-ser-arg)] with a core sequence of cell adhesion molecules.

K. Sugimura, I. Saiki, J. Murata, 1989, British Journal of Cancer.

Role of chemokine CX 3 CL 1 in progression of multiple myeloma via CX 3 CR 1 in bone microenvironments

K. Tsuneyama, T. Sugiyama, H. Sakurai, 2015 .

Activation of MEK/ERK and PI3K/Akt pathways by fibronectin requires integrin αv‐mediated ADAM activity in hepatocellular carcinoma: A novel functional target for gefitinib

H. Sakurai, I. Saiki, Y. Ueno, 2006, Cancer science.

RANKL-induced CCL22/macrophage-derived chemokine produced from osteoclasts potentially promotes the bone metastasis of lung cancer expressing its receptor CCR4

H. Sakurai, I. Saiki, K. Koizumi, 2006, Clinical & Experimental Metastasis.

Differential Regulation of Th1 and Th2 Functions of NKT Cells by CD28 and CD40 Costimulatory Pathways1

I. Saiki, K. Takeda, H. Yagita, 2001, The Journal of Immunology.

Antimetastatic effect of endogenous tumor necrosis factor induced by the treatment of recombinant interferon γ followed by an analogue (GLA-60) to synthetic lipid A subunit

I. Saiki, H. Maeda, J. Murata, 2005, Cancer Immunology, Immunotherapy.

Monoclonal antibodies to Lewis lung carcinoma

I. Saiki, I. Azuma, S. Ukei, 2004, Journal of Cancer Research and Clinical Oncology.

Functional Analysis of Mononuclear Cells Infiltrating into Tumors: Establishment of T Cell Hybridomas Exhibiting Distinct Interacting Abilities with Endothelial Cells and Extracellular Matrix Components

I. Saiki, T. Uede, K. Kikuchi, 1993, Japanese journal of cancer research : Gann.

Quercetin inhibits the invasion and mobility of murine melanoma B16-BL6 cells through inducing apoptosis via decreasing Bcl-2 expression

Qiang Xu, I. Saiki, Xianming Zhang, 2004, Clinical & Experimental Metastasis.

Preventive effect of oral administration of 6-(methylsulfinyl)hexyl isothiocyanate derived from wasabi (Wasabia japonica Matsum) against pulmonary metastasis of B16-BL6 mouse melanoma cells.

I. Saiki, K. Ryoyama, K. Koizumi, 2006, Cancer detection and prevention.

Nonthmicin, a Polyether Polyketide Bearing a Halogen-Modified Tetronate with Neuroprotective and Antiinvasive Activity from Actinomadura sp.

I. Saiki, Y. Igarashi, E. Tashiro, 2017, Organic letters.

Functional roles of tumor necrosis factor‐related apoptosis‐inducing ligand–DR5 interaction in B16F10 cells by activating the nuclear factor‐κB pathway to induce metastatic potential

T. Irimura, I. Saiki, K. Takeda, 2013, Cancer science.

High-level expression of chemokine CXCL16 by tumor cells correlates with a good prognosis and increased tumor-infiltrating lymphocytes in colorectal cancer.

K. Tsuneyama, Y. Takano, H. Sakurai, 2007, Cancer research.

High-level expression of chemokine CXCL16 by tumor cells correlates with a good prognosis and increased tumor-infiltrating lymphocytes in colorectal cancer.

K. Tsuneyama, Y. Takano, H. Sakurai, 2007, Cancer Research.

Gomisin N enhances TRAIL-induced apoptosis via reactive oxygen species-mediated up-regulation of death receptors 4 and 5

H. Sakurai, I. Saiki, Y. Shimada, 2011, International journal of oncology.

Characterization of a liver metastatic variant of murine colon 26 carcinoma cells.

I. Saiki, J. Murata, M. Fujimaki, 1997, Tumour biology : the journal of the International Society for Oncodevelopmental Biology and Medicine.

Prevention of Intrahepatic Metastasis by Curcumin in an Orthotopic Implantation Model

H. Sakurai, I. Saiki, K. Koizumi, 2003, Oncology.

Inhibition by vasoactive intestinal polypeptide (VIP) of angiogenesis induced by murine Colon 26-L5 carcinoma cells metastasized in liver

I. Saiki, J. Murata, Kazuko Hayashi, 1999, Clinical & Experimental Metastasis.

Quantitative fluorescent microassay for identification of antiproliferative compounds.

J. Y. Tsao, C. Bucana, I. Fidler, 1986, Journal of the National Cancer Institute.

Antimetastatic Activity of Polymeric RGDT Peptides Conjugated with Poly(ethylene glycol)

N. Kusunose, I. Saiki, I. Azuma, 1993, Japanese journal of cancer research : Gann.

Retrospective screening of microarray data to identify candidate IFN-inducible genes in a HTLV-1 transformed model

H. Sakurai, I. Saiki, Sherif Abdelhamed, 2018, Oncology letters.

Inhibition of the metastasis of murine malignant melanoma by synthetic polymeric peptides containing core sequences of cell-adhesive molecules.

K. Sugimura, I. Saiki, J. Murata, 1989, Cancer research.

Kampo formulations and allergic inflammatory diseases

I. Saiki, 2004 .

A Kampo formulation: Byakko-ka-ninjin-to (Bai-Hu-Jia-Ren-Sheng-Tang) inhibits IgE-mediated triphasic skin reaction in mice: the role of its constituents in expression of the efficacy.

I. Saiki, K. Terasawa, T. Yamada, 2001, Biological & pharmaceutical bulletin.

Inhibitory mechanisms of glycoprotein fraction derived from Miscanthus sinensis for the immediate phase response of an IgE-mediated cutaneous reaction.

I. Saiki, K. Hase, S. Kadota, 1999, Biological & pharmaceutical bulletin.

A third-phase cutaneous (very late phase) response after elicitation with dinitrofluorobenzene in passively or actively sensitized mice

I. Saiki, K. Terasawa, Y. Shimada, 2000 .

Effect of Shimotsu-to (a Kampo medicine, Si-Wu-Tang) and its constituents on triphasic skin reaction in passively sensitized mice.

I. Saiki, K. Terasawa, Y. Shimada, 1999, Journal of ethnopharmacology.

A ginseng saponin metabolite suppresses tumor necrosis factor-alpha-promoted metastasis by suppressing nuclear factor-kappaB signaling in murine colon cancer cells.

Dong-Hyun Kim, H. Sakurai, M. Choo, 2008, Oncology reports.

COP9 signalosome subunit 5 regulates cancer metastasis by deubiquitinating SNAIL

H. Sakurai, I. Saiki, J. Fukuoka, 2018, Oncotarget.

4-[3,5-Bis(trimethylsilyl)benzamido] benzoic acid (TAC-101) inhibits the intrahepatic spread of hepatocellular carcinoma and prolongs the life-span of tumor-bearing animals

I. Saiki, T. Matsuura, Yuji Yamada, 1998, Clinical & Experimental Metastasis.

Antitumor activity of squalene-treated cell-wall skeleton of Nocardia rubra in mice.

I. Saiki, I. Azuma, Y. Yamamura, 1978, Gan.

Artificial cytokine storm combined with hyperthermia induces significant anti-tumor effect in mice inoculated with Lewis lung carcinoma and B16 melanoma cells

I. Saiki, T. Yanagawa, T. Ishii, 2006, International journal of hyperthermia : the official journal of European Society for Hyperthermic Oncology, North American Hyperthermia Group.

Blocking on the CXCR4/mTOR signalling pathway induces the anti-metastatic properties and autophagic cell death in peritoneal disseminated gastric cancer cells.

S. Saito, H. Sakurai, I. Saiki, 2008, European journal of cancer.

Differential Effect of Antiallergic Drugs on IgE-Mediated Cutaneous Reaction in Passively Sensitized Mice

I. Saiki, K. Terasawa, H. Nagai, 2000, Pharmacology.

Inhibitory effect of tumor metastasis in mice by saponins, ginsenoside-Rb2, 20(R)- and 20(S)-ginsenoside-Rg3, of red ginseng.

Y. Yoo, I. Saiki, I. Azuma, 1995, Biological & pharmaceutical bulletin.

In vivo anti-metastatic action of Ginseng Saponins is based on their intestinal bacterial metabolites after oral administration

I. Saiki, 2007 .

Anti-metastatic Effect of Ginseng Saponins and its Molecular Mechanism

I. Saiki, 2003 .

Synergism between human recombinant gamma-interferon and muramyl dipeptide encapsulated in liposomes for activation of antitumor properties in human blood monocytes.

I. Fidler, S. Sone, G. Lopez-Berestein, 1985, Cancer research.

Lupinacidin C, an inhibitor of tumor cell invasion from Micromonospora lupini.

I. Saiki, Y. Igarashi, M. Trujillo, 2011, Journal of natural products.

Eotaxin‐induced expression of membrane type 1 matrix metalloproteinase mRNA in human eosinophils

I. Saiki, N. Mitani, K. Murakami, 2000 .

Social isolation stress impairs the resistance of mice to experimental liver metastasis of murine colon 26-L5 carcinoma cells.

I. Saiki, J. Murata, T. Yamaura, 2001, Biological & pharmaceutical bulletin.

A new formulation containing eleven crude drugs devised by the cooperative research project in Toyama

I. Saiki, Y. Shimada, T. Tani, 2006 .

A newly devised formulation for self-medication enhances interferon-gamma production and proliferation of splenic lymphocytes.

H. Sakurai, I. Saiki, K. Koizumi, 2005, Biological & pharmaceutical bulletin.

Effect of prostatic neuropeptides on migration of prostate cancer cell lines

H. Fuse, I. Saiki, J. Murata, 2001, International journal of urology : official journal of the Japanese Urological Association.

Identification of TNF‐α‐responsive NF‐κB p65‐binding element in the distal promoter of the mouse serine protease inhibitor SerpinE2

H. Nakano, H. Sakurai, I. Saiki, 2006 .

Chemosensitizing Effect of Saikosaponin B on B16F10 Melanoma Cells

I. Saiki, S. Yokoyama, Y. Hayakawa, 2017, Nutrition and cancer.

Effect of chromogranin A (pancreastatin) fragment on invasion of prostate cancer cells.

H. Fuse, I. Saiki, J. Murata, 1999, Cancer letters.

Bufotalin sensitizes death receptor-induced apoptosis via Bid- and STAT1-dependent pathways.

H. Sakurai, I. Saiki, A. Inujima, 2011, International journal of oncology.

Inhibitory effect of Moutan Cortex aqueous fraction on mast cell-mediated allergic inflammation

Ji-Ye Kee, H. Sakurai, I. Saiki, 2015, Journal of Natural Medicines.

Therapeutic effect of cell-wall skeleton of Propionibacterium acnes in combination with a monoclonal antibody (C6-1.2) on the lung metastases of Lewis lung carcinoma.

I. Saiki, I. Azuma, S. Saito, 1987, Japanese journal of cancer research : Gann.

Immune adjuvant effect of Juzentaihoto, a Japanese traditional herbal medicine, on tumor vaccine therapy in a mouse model.

H. Sakurai, I. Saiki, K. Koizumi, 2015, International journal of oncology.

Critical contribution of IFN-gamma and NK cells, but not perforin-mediated cytotoxicity, to anti-metastatic effect of alpha-galactosylceramide.

Y. Iwakura, I. Saiki, K. Takeda, 2001, European journal of immunology.

Identification of Hirsutine as an anti-metastatic phytochemical by targeting NF-κB activation.

T. Irimura, I. Saiki, Kei Takahashi, 2014, International journal of oncology.

Therapeutics target of CXCR4 and its downstream in peritoneal carcinomatosis of gastric cancer.

H. Sakurai, I. Saiki, K. Koizumi, 2012, Frontiers in bioscience.

Anti-tumor effect of combining CC chemokine 22 and an anti-CD25 antibody on myeloma cells implanted subcutaneously into mice.

H. Sakurai, I. Saiki, K. Koizumi, 2009, Molecular medicine reports.

The adjuvant activity of synthetic N-acetylmuramyl-dipeptide: evidence of initial target cells for the adjuvant activity.

K. Sugimura, I. Saiki, I. Azuma, 1979, Cellular immunology.

Antimetastatic and immunostimulatory properties of fermented brown rice

H. Sakurai, M. Choo, I. Saiki, 2006 .

Urinary trypsin inhibitor suppresses surgical stress-facilitated lung metastasis of murine colon 26-L5 carcinoma cells.

H. Sakurai, I. Saiki, K. Koizumi, 2005, Anticancer research.

Influence of growth factors on in vitro invasiveness and type IV collagenolysis of human renal cell carcinoma cells.

N. Masumori, I. Saiki, T. Tsukamoto, 1994, The Journal of urology.

Synergistic activation by recombinant mouse interferon-gamma and muramyl dipeptide of tumoricidal properties in mouse macrophages.

I. Fidler, I. Saiki, 1985, Journal of immunology.

Involvement of peripheral adenosine 5′‐triphosphate and P2X purinoceptor in pain‐related behavior produced by orthotopic melanoma inoculation in mice

I. Saiki, M. Fujita, Y. Kuraishi, 2010, The European journal of neuroscience.

Antiproliferative activity of cardenolides isolated from Streptocaulon juventas.

Q. K. Tran, I. Saiki, S. Kadota, 2003, Biological & pharmaceutical bulletin.

Antiproliferative activity of Vietnamese medicinal plants.

Q. K. Tran, I. Saiki, S. Kadota, 2002, Biological & pharmaceutical bulletin.

Anti-angiogenic effect of curcumin, curcumin ethylenediamine derivative and curcumin ethylenediamine manganese complex

I. Saiki, K. Koizumi, Y. Saitoh, 2004 .

TAK1‐mediated transcriptional activation of CD28‐responsive element and AP‐1‐binding site within the IL‐2 promoter in Jurkat T cells

H. Sakurai, I. Saiki, K. Koizumi, 2005, FEBS letters.

Selective antiproliferative activity of caffeic acid phenethyl ester analogues on highly liver-metastatic murine colon 26-L5 carcinoma cell line.

I. Saiki, S. Kadota, Y. Tezuka, 2002, Bioorganic & medicinal chemistry.

Antiproliferative activity of diarylheptanoids from the seeds of Alpinia blepharocalyx.

I. Saiki, S. Kadota, Y. Tezuka, 2001, Biological & pharmaceutical bulletin.

The expression of in vivo anti-metastatic effect of Ginseng protopanaxatriol saponins is mediated by their intestinal bacterial metabolites after oral administration

I. Saiki, J. Murata, C. Wakabayashi, 1997 .

Role of T cells in IgE‐dependent triphasic cutaneous reaction caused by dinitrofluorobenzene in the mouse ear: Participation of CD8+ T cells

I. Saiki, T. Ochi, Hiroyuki Tanaka, 2003 .

Functional role of sialyl Lewis X and fibronectin‐derived RGDS peptide analogue on tumor‐cell arrest in lungs followed by extravasation

H. Tsukada, I. Saiki, J. Murata, 1996, International journal of cancer.

[Screening for inhibitors of tumor invasion into basement membranes].

I. Saiki, 2004, Gan to kagaku ryoho. Cancer & chemotherapy.

Synthesis and structure–activity relationships studies of brartemicin analogs as anti-invasive agents

I. Saiki, Y. Igarashi, Xiu-zhen Han, 2013, The Journal of Antibiotics.

Synthesis and evaluation of trehalose-based compounds as anti-invasive agents.

I. Saiki, Y. Igarashi, S. Miyanaga, 2011, Bioorganic & medicinal chemistry letters.

Structures and biological activities of peptidoglycans of Listeria monocytogenes and Propionibacterium acnes.

I. Saiki, I. Azuma, Y. Tanio, 1982, Journal of biochemistry.

Involvement of endothelin and ET(A) endothelin receptor in mechanical allodynia in mice given orthotopic melanoma inoculation.

I. Saiki, M. Fujita, Y. Kuraishi, 2008, Journal of pharmacological sciences.

Application of interleukin 12 to antitumor cytokine and gene therapy

M. Kimura, Kazuhito Watanabe, K. Ando, 1996, Cancer Chemotherapy and Pharmacology.

A new pseudo-peptide of Arg-Gly-Asp (RGD) with inhibitory effect on tumor metastasis and enzymatic degradation of extracellular matrix

I. Saiki, I. Azuma, Makoto Suzuki, 2004, Clinical & Experimental Metastasis.

Imaging of thrombosis and microcirculation in mouse lungs of initial melanoma metastasis with in vivo cryotechnique.

I. Saiki, T. Jin, Y. Saitoh, 2014, Microvascular research.

Critical contribution of IFN‐γ and NK cells, but not perforin‐mediated cytotoxicity, to anti‐metastatic effect of α‐galactosylceramide

Y. Iwakura, I. Saiki, K. Takeda, 2001 .

Campechic acids A and B: anti-invasive polyether polyketides from a soil-derived Streptomyces.

I. Saiki, Y. Igarashi, M. Trujillo, 2014, Journal of natural products.

Immunological activities of multiprenylacetyl derivatives of muramyldipeptides.

I. Saiki, J. Iida, I. Azuma, 1988, Vaccine.

Anti-viral activity of sulfated chitin derivatives against Friend murine leukaemia and herpes simplex type-1 viruses.

I. Saiki, I. Azuma, S. Tokura, 1993, Vaccine.

Anti-invasive and anti-angiogenic activities of naturally occurring dibenzodiazepine BU-4664L and its derivatives.

H. Sakurai, I. Saiki, Y. Igarashi, 2010, Bioorganic & medicinal chemistry letters.

New spirostanol steroids and steroidal saponins from roots and rhizomes of Dracaena angustifolia and their antiproliferative activity.

Q. K. Tran, I. Saiki, S. Kadota, 2001, Journal of natural products.

Induction of apoptosis in Lewis lung carcinoma cells by an intestinal bacterial metabolite produced from orally administered ginseng protopanaxadiol saponins.

I. Saiki, K. Murakami, H. Hasegawa, 2000 .

Recombinant human granulocyte colony‐stimulating factor inhibits the metastasis of hematogenous and non‐hematogenous tumors in mice

I. Saiki, J. Murata, I. Azuma, 1991, International journal of cancer.

Stimulation of cultured colon 26 cells with TNF-alpha promotes lung metastasis through the extracellular signal-regulated kinase pathway.

H. Sakurai, M. Choo, I. Saiki, 2005, Cancer letters.

Effect of Keishibukuryogan on Genetic and Dietary Obesity Models

K. Tsuneyama, I. Saiki, S. Yokoyama, 2015, Evidence-based complementary and alternative medicine : eCAM.

The Long-Term Effects of a Kampo Medicine, Juzentaihoto, on Maintenance of Antibody Titer in Elderly People after Influenza Vaccination

H. Sakurai, I. Saiki, K. Koizumi, 2013, Evidence-based complementary and alternative medicine : eCAM.

Intrahepatic Metastasis by Orthotopic Implantation of a Fragment of Murine Hepatoma and Its Related Molecules

I. Saiki, K. Tsukada, S. Sawada, 2001, Tumor Biology.

Inhibition of tumour cell adhesion by anti-metastatic polypeptide containing a repetitive Arg-Gly-Asp sequence.

I. Saiki, J. Murata, J. Iida, 1989, International journal of biological macromolecules.

ZD 1839 , a Selective Epidermal Growth Factor Receptor Tyrosine Kinase Inhibitor , Shows Antimetastatic Activity Using a Hepatocellular Carcinoma Model 1

H. Sakurai, I. Saiki, M. Matsuo, 2003 .

Role of Th1 and Th2 cytokines in regulating the liver injury induced by delayed-type hypersensitivity to picryl chloride.

I. Saiki, Y. Hayakawa, A. Koda, 1999, Liver.

Differential effect of chromogranin A fragments on invasion and growth of prostate cancer cells in vitro.

Y. Fujiuchi, H. Fuse, I. Saiki, 2003, Urology.

In vitro invasive potential and type IV collagenolytic activity of human renal cell carcinoma cells derived from primary and metastatic lesions.

I. Saiki, T. Tsukamoto, J. Yoneda, 1993, The Journal of urology.

Catechoserine, a new catecholate-type inhibitor of tumor cell invasion from Streptomyces sp.

H. Sakurai, I. Saiki, T. Iida, 2012, The Journal of Antibiotics.

Absolute configuration of pterocidin, a potent inhibitor of tumor cell invasion from a marine-derived Streptomyces

H. Sakurai, I. Saiki, Y. Igarashi, 2012 .

Inducible capillary formation in lymphatic endothelial cells by blocking lipid phosphate phosphatase-3 activity.

Y. Tabuchi, I. Takasaki, H. Sakurai, 2009, Lymphatic research and biology.

Inhibitory Effect of Fibronectin and Its Recombinant Polypeptides on the Adhesion of Metastatic Melanoma Cells to Laminin

I. Saiki, J. Murata, I. Azuma, 1991, Japanese journal of cancer research : Gann.

Inhibitory Effect of Antimetastatic Fusion Polypeptide of Human Fibronectin on Tumor Cell Adhesion to Extracellular Matrices

I. Saiki, J. Murata, I. Azuma, 1991, Japanese journal of cancer research : Gann.

Activation of mouse peritoneal adherent cells with N-acyl muramyl dipeptide derivatives

I. Saiki, I. Azuma, K. Nishimura, 1985, Infection and immunity.

Activation of macrophages by quinonyl-N-acetylmuramyl dipeptide

I. Saiki, I. Azuma, K. Nishimura, 1983, Infection and immunity.

Establishment and characterization of conditionally immortalized endothelial cell lines from the thoracic duct and inferior vena cava of tsA58/EGFP double-transgenic rats

M. Obinata, T. Terasaki, I. Saiki, 2006, Cell and Tissue Research.

Anti‐inflammatory effect of fermented brown rice and rice bran with Aspergillus oryzae on mice

I. Saiki, Lin Umeyama, Shiori Kasahara, 2020 .

Effect of Juzentaihoto/Shi-Quan-Da-Bu-Tang on malignant progression and metastasis of tumor cells

I. Saiki, S. Yokoyama, Y. Hayakawa, 2017 .

Oral Administration of a Kampo (Japanese Herbal) Medicine Juzen‐taiho‐to Inhibits Liver Metastasis of Colon 26‐L5 Carcinoma Cells

I. Saiki, M. Fujimaki, Y. Hayakawa, 1998, Japanese journal of cancer research : Gann.

Cochinin B, a novel ribosome-inactivating protein from the seeds of Momordica cochinchinensis.

H. Sakurai, I. Saiki, K. Oda, 2007, Biological & pharmaceutical bulletin.

p38‐Mediated phosphorylation of Eps15 endocytic adaptor protein

Y. Ishihama, T. Sakuma, H. Sakurai, 2014, FEBS letters.

Studies on lymphangiogenesis inhibitors from Korean and Japanese crude drugs.

M. Ono, Youn-Chul Kim, I. Saiki, 2013, Biological & pharmaceutical bulletin.

Adhesion polypeptides are useful for the prevention of peritoneal dissemination of gastric cancer

T. Sawada, M. Yashiro, I. Saiki, 1998, Clinical & Experimental Metastasis.

Inhibition of tumor metastasis by Arg-Gly-Asp-Ser (RGDS) peptide conjugated with sulfated chitin derivative, SCM-chitin-RGDS

Y. Yoo, I. Saiki, I. Azuma, 1993, Clinical & Experimental Metastasis.

Synthetic Arg-Gly-Asp-Ser analogues of the cell recognition site of fibronectin that retain antimetastatic and anti-cell adhesive properties.

H. Satoh, I. Saiki, I. Azuma, 1993, Biological & pharmaceutical bulletin.

The conjugation of RGDS peptide with CM-chitin augments the peptide-mediated inhibition of tumor metastasis

I. Saiki, I. Azuma, S. Tokura, 1993 .

Effects of Recombinant Human Tissue Inhibitor of Metalloproteinases‐2 (rh‐TIMP‐2) on Migration of Epidermal Keratinocytes In vitro and Wound Healing In vivo

I. Saiki, K. Iwata, T. Aoki, 2003, The Journal of dermatology.

A novel synthetic lipid A analog with low endotoxicity, DT-5461, prevents lethal endotoxemia

Y. Yoo, I. Saiki, I. Azuma, 1995, Infection and immunity.

Anti-invasive activity of synthetic serine protease inhibitors and its combined effect with a matrix metalloproteinase inhibitor.

I. Saiki, Y. Hayakawa, H. Fujii, 1998, Anticancer research.

Costimulatory Pathways Functions of NKT Cells by CD28 and CD40 Differential Regulation of Th1 and Th2

L. Kaer, I. Saiki, K. Takeda, 2001 .

IFN-gamma-mediated inhibition of tumor angiogenesis by natural killer T-cell ligand, alpha-galactosylceramide.

M. Smyth, I. Saiki, K. Takeda, 2002, Blood.

Vaccination with B7-1+ Tumor and Anti-Adhesion Therapy with RGD Pseudo-Peptide (FC-336) Efficiently Induce Anti-Metastatic Effect

M. Murakami, I. Saiki, I. Azuma, 1998, Clinical & Experimental Metastasis.

Vaccination of tumor cells transfected with the B7‐1 (CD80) gene induces the anti‐metastatic effect and tumor immunity in mice

I. Saiki, J. Murata, I. Azuma, 1996, International journal of cancer.

HPLC analysis of juzen-taiho-to and its variant formulations and their antimetastatic efficacies.

I. Saiki, Y. Hayakawa, T. Yamaura, 1999, Chemical & pharmaceutical bulletin.

Effect of spikelets of Miscanthus sinensis on IgE-mediated biphasic cutaneous reaction in mice.

I. Saiki, K. Hase, S. Kadota, 1998, Planta medica.

Antimetastatic and antitumor effect of a recombinant human tissue inhibitor of metalloproteinases-2 in murine melanoma models.

A. Shinagawa, I. Saiki, T. Oku, 1997, Biological & pharmaceutical bulletin.

Influence of fibroblasts on the invasion and migration of highly or weakly metastatic b16 melanoma cells

I. Saiki, I. Azuma, J. Yoneda, 1994, International journal of cancer.

Multi-Pathway Cellular Analysis on Crude Natural Drugs/Herbs from Japanese Kampo Formulations

T. Abe, I. Saiki, S. Yokoyama, 2015, PloS one.

Inhibitory effect of minocycline on in vitro invasion and experimental metastasis of mouse renal adenocarcinoma.

N. Masumori, I. Saiki, T. Tsukamoto, 1994, The Journal of urology.

Expression of membrane-type 1 matrix metalloproteinase (MT1-MMP) on prostate cancer cell lines.

Y. Fujiuchi, H. Fuse, I. Saiki, 2000, Cancer letters.

Chemical constituents of Brazilian propolis and their cytotoxic activities.

I. Saiki, S. Kadota, Y. Tezuka, 1998, Journal of natural products.

Cytotoxic cycloartane-type triterpenes from Combretum quadrangulare.

Y. Miwa, I. Saiki, S. Kadota, 1998, Bioorganic & medicinal chemistry letters.

Staminol A, a novel diterpene from Orthosiphon stamineus

I. Saiki, Y. Tezuka, P. Stampoulis, 1999 .

Abyssomicin I, a modified polycyclic polyketide from Streptomyces sp. CHI39.

H. Sakurai, I. Saiki, Y. Igarashi, 2010, Journal of natural products.

Synthesis and evaluation of myxochelin analogues as antimetastatic agents.

H. Sakurai, I. Saiki, Y. Igarashi, 2009, Bioorganic & medicinal chemistry.

Bradykinin increases the secretion and expression of endothelin-1 through kinin B2 receptors in melanoma cells

I. Saiki, Y. Kuraishi, T. Andoh, 2010, Peptides.

Procyanidin C1 from Cinnamomi Cortex inhibits TGF-β-induced epithelial-to-mesenchymal transition in the A549 lung cancer cell line.

H. Sakurai, Feng Li, I. Saiki, 2013, International journal of oncology.

Constituents of the Vietnamese medicinal plant Orthosiphon stamineus.

I. Saiki, S. Kadota, Y. Tezuka, 2000, Chemical & pharmaceutical bulletin.

Critical contribution of MCL-1 in EMT-associated chemo-resistance in A549 non-small cell lung cancer.

H. Sakurai, I. Saiki, S. Yokoyama, 2015, International journal of oncology.

Tumor Necrosis Factor-α-induced IKK Phosphorylation of NF-κB p65 on Serine 536 Is Mediated through the TRAF2, TRAF5, and TAK1 Signaling Pathway*

Takahiro Doi, Hiroaki Sakurai, H. Nakano, 2003, Journal of Biological Chemistry.

A Kampo medicine "Juzen-taiho-to"--prevention of malignant progression and metastasis of tumor cells and the mechanism of action.

I. Saiki, 2000, Biological & pharmaceutical bulletin.

Expression of the anti-metastatic effect induced by Juzen-taiho-to is based on the content of Shimotsu-to constituents.

I. Saiki, K. Tsukada, T. Yamaura, 1998, Biological & pharmaceutical bulletin.

Thirteen novel cycloartane-type triterpenes from Combretum quadrangulare.

I. Saiki, S. Kadota, Y. Tezuka, 2000, Journal of natural products.

Methanol extract of Polygonati Rhizoma enhances the tube formation of rat lymphatic endothelial cells

H. Sakurai, I. Saiki, K. Koizumi, 2010 .

Methyl quadrangularates A-D and related triterpenes from Combretum quadrangulare.

I. Saiki, S. Kadota, Y. Tezuka, 2000, Chemical & pharmaceutical bulletin.

Dipasperoside A, a novel pyridine alkaloid-coupled iridoid glucoside from the roots of Dipsacus asper.

Shiro Watanabe, I. Saiki, Y. Tezuka, 2013, Chemical & pharmaceutical bulletin.

Anti-inflammatory effect of cinnamaldehyde in Helicobacter pylori induced gastric inflammation.

T. Sugiyama, I. Saiki, K. Usmanghani, 2015, Biological & pharmaceutical bulletin.

Iodine-catalyzed etherification of morroniside.

H. Sakurai, I. Saiki, M. Koketsu, 2009, Chemical & pharmaceutical bulletin.

Induction of tumoricidal macrophages and production of cytokines by synthetic muramyl dipeptide analogues.

I. Saiki, J. Murata, J. Iida, 1988, Vaccine.

Constituents of the Vietnamese medicinal plant Streptocaulon juventas and their antiproliferative activity against the human HT-1080 fibrosarcoma cell line.

Shigetoshi Kadota, Yasuhiro Tezuka, Q. K. Tran, 2003, Journal of natural products.

RANKL-induced down-regulation of CX3CR1 via PI3K/Akt signaling pathway suppresses Fractalkine/CX3CL1-induced cellular responses in RAW264.7 cells.

H. Sakurai, I. Saiki, K. Koizumi, 2007, Biochemical and biophysical research communications.

Cytotoxic Cardiac Glycosides from the Roots of Streptocaulon juventas

H. Sakurai, I. Saiki, Na Han, 2012, Planta Medica.

Efficient Use of a Crude Drug/Herb Library Reveals Ephedra Herb As a Specific Antagonist for TH2-Specific Chemokine Receptors CCR3, CCR4, and CCR8

K. Matsuo, I. Saiki, K. Koizumi, 2016, Front. Cell Dev. Biol..

Anti-invasive and anti-angiogenic activities of Curcuma sp. extracts

I. Saiki, K. Koizumi, K. Komatsu, 2004 .

Modulation of Activation‐Induced Cytidine Deaminase by Curcumin in Helicobacter pylori‐Infected Gastric Epithelial Cells

T. Kondo, T. Sugiyama, H. Sakurai, 2009, Helicobacter.

Artesunate enhances TRAIL-induced apoptosis in human cervical carcinoma cells through inhibition of the NF-κB and PI3K/Akt signaling pathways.

H. Sakurai, I. Saiki, O. Thanaketpaisarn, 2011, International journal of oncology.

Adjuvant activities of synthetic lipid A subunit analogues and its conjugates with muramyl dipeptide derivatives.

I. Saiki, H. Maeda, M. Kiso, 1989, Vaccine.

MDP-Lys(L18), a lipophilic derivative of muramyl dipeptide, inhibits the metastasis of haematogenous and non-haematogenous tumours in mice.

Y. Yoo, I. Saiki, I. Azuma, 1994, Vaccine.

Protective activity of recombinant cytokines against Sendai virus and herpes simplex virus (HSV) infections in mice.

I. Saiki, J. Iida, I. Azuma, 1989, Vaccine.

Adjuvant activity of purified peptidoglycan of Listeria monocytogenes in mice and guinea pigs

I. Saiki, I. Azuma, Y. Tanio, 1982, Infection and immunity.

Adjuvant activities of quinonyl-N-acetyl muramyl dipeptides in mice and guinea pigs

I. Saiki, I. Azuma, Y. Tanio, 1981, Infection and immunity.

Adjuvant activity of N-acetyl muramyl dipeptides for the induction of delayed-type hypersensitivity to azobenzenearsonate-N-acetyl-L-tyrosine in guinea pigs.

I. Saiki, I. Azuma, Y. Tanio, 1980, Infection and immunity.

Antimetastatic activity of neocarzinostatin incorporated into controlled release gels of CM-chitin

Y. Uraki, H. Seo, I. Saiki, 1992 .

B30-MDP, a synthetic muramyl dipeptide derivative for tumour vaccination to enhance antitumour immunity and antimetastatic effect in mice.

Y. Yoo, I. Saiki, I. Azuma, 1992, Vaccine.

Inhibition of tumor-induced angiogenesis by sulfated chitin derivatives.

I. Saiki, J. Murata, I. Azuma, 1991, Cancer research.

Inhibition of Tumor Cell Arrest in Lungs by Antimetastatic Chitin Heparinoid

I. Saiki, J. Murata, I. Azuma, 1990, Japanese journal of cancer research : Gann.

Prophylactic activity against Sendai virus infection and macrophage activation with lipophilic derivatives of N-acetylglucosaminylmuramyl tri- or tetrapeptides.

I. Saiki, J. Iida, I. Azuma, 1989, Vaccine.

Lethal and adjuvant activities of cord factor (trehalose-6,6'-dimycolate) and synthetic analogs in mice.

I. Saiki, I. Azuma, H. Ishida, 1985, Chemical & pharmaceutical bulletin.

Immunological activity of chitin and its derivatives.

I Saiki, I. Saiki, I. Azuma, 1984, Vaccine.

LEA-1/ICAM-1 interaction is essentially involved in the pathogenesis of delayed-type hypersensitivity-induced liver injury to picryl chloride.

I. Saiki, H. Fujii, F. Wu, 1998, Life sciences.

Chemokine receptor CXCR4 expression and prognosis in patients with metastatic prostate cancer

K. Tsuneyama, H. Fuse, Y. Takano, 2008, Cancer science.

Antitumor anthraquinones from an endophytic actinomycete Micromonospora lupini sp. nov.

H. Sakurai, I. Saiki, E. Martı́nez-Molina, 2007, Bioorganic & medicinal chemistry letters.

Rakicidin D, an inhibitor of tumor cell invasion from marine-derived Streptomyces sp.

H. Sakurai, I. Saiki, Y. Igarashi, 2010, The Journal of Antibiotics.

Inhibition of p38 mitogen-activated protein kinase potentiates the apoptotic effect of berberine/tumor necrosis factor-related apoptosis-inducing ligand combination therapy.

H. Sakurai, I. Saiki, Sherif Abdelhamed, 2015, Oncology letters.

Antimetastatic and immunomodulating properties of a new herbal prescription, Bojung-bangam-tang.

Sung-Hoon Kim, I. Saiki, Y. Hayakawa, 2003, International immunopharmacology.

Prevention of growth and metastasis of murine melanoma through enhanced natural-killer cytotoxicity by fatty acid-conjugate of protopanaxatriol.

I. Saiki, S. Kadota, Y. Tezuka, 2002, Biological & pharmaceutical bulletin.

Inhibitory effect of vasoactive intestinal polypeptide (VIP) on experimental liver metastasis by murine colon 26-L5 carcinoma cells.

I. Saiki, J. Murata, M. Ogasawara, 1998, Oncology research.

Direct antiproliferative effects of recombinant human interferon-alpha B/D hybrids on human tumor cell lines.

I. Fidler, I. Saiki, M. Grutter, 1987, Cancer research.

In vivo antimetastatic action of ginseng protopanaxadiol saponins is based on their intestinal bacterial metabolites after oral administration.

I. Saiki, J. Murata, C. Wakabayashi, 1997, Oncology research.

Inhibition of tumor angiogenesis and metastasis by a saponin of Panax ginseng, ginsenoside-Rb2.

Katsuaki Sato, Y. Yoo, I. Saiki, 1994, Biological & pharmaceutical bulletin.

Inhibition by galloylglucose (GG6-10) of tumor invasion through extracellular matrix and gelatinase-mediated degradation of type IV collagens by metastatic tumor cells.

M. Nakajima, I. Saiki, T. Oku, 1996, Oncology research.

1,3-Selenazine derivatives induce cytotoxicity and DNA fragmentation in human HT-1080 fibrosarcoma cells.

I. Saiki, K. Murakami, W. Wu, 1999, European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences.

Induction of apoptosis in human gastric adenocarcinoma cells by two novel organoselenium compounds, TS-2 and TS-6.

I. Saiki, K. Murakami, W. Wu, 1999, Anticancer research.

Alpha-melanocyte-stimulating hormone blocks invasion of reconstituted basement membrane (Matrigel) by murine B16 melanoma cells.

I. Saiki, J. Murata, H. Fujii, 1997, Invasion & metastasis.

Liposomal Arg-Gly-Asp analogs effectively inhibit metastatic B16 melanoma colonization in murine lungs.

I. Saiki, N. Oku, Y. Tokudome, 1996, Life sciences.

Antimetastatic activities of synthetic Arg-Gly-Asp-Ser (RGDS) and Arg-Leu-Asp-Ser (RLDS) peptide analogues and their inhibitory mechanisms.

I. Saiki, J. Murata, I. Azuma, 1995, Biological & pharmaceutical bulletin.

Invasiveness of hepatocellular carcinoma cell lines: contribution of membrane-type 1 matrix metalloproteinase.

I. Saiki, T. Matsuura, Yuji Yamada, 1999, Neoplasia.

Comparison of antimetastatic effect against Lewis lung carcinoma after intratumoral and intravenous injections of cell-wall skeleton of Propionibacterium acnes C7 in C57BL/6 mice.

I. Saiki, I. Azuma, Y. Tanio, 1984, Gan.

Brartemicin, an inhibitor of tumor cell invasion from the actinomycete Nonomuraea sp.

H. Sakurai, I. Saiki, Y. Igarashi, 2009, Journal of natural products.

Inhibition of Tumor Cell Invasion by Ubenimex (Bestatin) in vitro

I. Saiki, J. Murata, I. Azuma, 1989, Japanese journal of cancer research : Gann.

acute lymphoblastic leukemia cells Inhibitory effect of interleukin-4 on the in vitro growth of Ph1- positive

T. Miyazaki, M. Kurosawa, I. Saiki, 2013 .

acute lymphoblastic leukemia cells Inhibitory effect of interleukin-4 on the in vitro growth of Ph 1-positive

I. Saiki, T. Minagawa, T. Itaya, 2003 .

Inhibition of Tumor Metastasis by a Synthetic Polymer Containing a Cell-Adhesive RGDS Peptide

I. Saiki, I. Azuma, M. Kojima, 1993 .

Structural and immunochemical studies of teichoic acid of Listeria monocytogenes.

I. Saiki, I. Azuma, Y. Araki, 1983, Journal of biochemistry.

Pharmaceutical evaluation of Glycyrrhiza uralensis roots cultivated in eastern Nei-Meng-Gu of China.

I. Saiki, Yutaka Yamamoto, T. Tani, 2003, Biological & pharmaceutical bulletin.

Targeting the ataxia telangiectasia mutated pathway for effective therapy against hirsutine-resistant breast cancer cells.

I. Saiki, S. Yokoyama, Y. Hayakawa, 2016, Oncology letters.

Chemokine CXCL16 suppresses liver metastasis of colorectal cancer via augmentation of tumor-infiltrating natural killer T cells in a murine model.

Osamu Yoshie, Hiroaki Sakurai, Naotoshi Shibahara, 2013, Oncology reports.

Inhibition of Lung Metastasis by Synthetic and Recombinant Fragments of Human Fibronectin with Functional Domains

I. Saiki, J. Murata, I. Azuma, 1990, Japanese journal of cancer research : Gann.

Antimetastatic Effect by Anti‐adhesion Therapy with Cell‐adhesive Peptide of Fibronectin in Combination with Anticancer Drugs

I. Saiki, I. Azuma, I. Kato, 1993, Japanese journal of cancer research : Gann.

Adjuvant Activity of 6-Amino-6-Deoxy-Muramyldipeptides and Their Acylamino Derivatives on the Induction of Delayed Hypersensitivity to Azobenzenearsonate-N-Acetyl-l-Tyrosine in Guinea Pigs

I. Saiki, M. Kiso, A. Hasegawa, 1981, Infection and immunity.

Adjuvant Activity of Mycoloyl Derivatives of N‐Acetylmuramyl‐L‐alanyl‐D‐isoglutamine in Mice and Guinea Pigs

I. Saiki, I. Azuma, T. Kusama, 1979, Microbiology and immunology.

Adjuvant activity of 6-O-mycoloyl derivatives of N-acetylmuramyl-L-seryl-D-isoglutamine and related compounds in mice and guinea pigs

K. Sugimura, I. Saiki, I. Azuma, 1979, Infection and immunity.

Application of liposomes for cancer metastasis

H. Tsukada, I. Saiki, J. Murata, 1997 .

Inhibitory Effect of Recombinant Fibronectin Polypeptides on the Adhesion of Liver‐metastatic Lymphoma Cells to Hepatic Sinusoidal Endothelial Cells and Tumor Invasion

I. Saiki, M. Kiso, A. Hasegawa, 1994, Japanese journal of cancer research : Gann.

Effect of 4-[3,5-bis(trimethylsilyl)benzamido] benzoic acid (TAC-101) on the liver metastasis of colon 26-L5 carcinoma cells.

I. Saiki, K. Murakami, Y. Yamada, 1998, Oncology research.

B / D Hybrids on Human Tumor Cell Lines α Interferon-Direct Antiproliferative Effects of Recombinant Human Updated Version

I. Fidler, I. Saiki, M. Grutter, 2006 .

IFN-γ–mediated inhibition of tumor angiogenesis by natural killer T-cell ligand, α-galactosylceramide

L. Kaer, M. Smyth, I. Saiki, 2002 .

5-Substituted pyrido[2,3-d]pyrimidine, an inhibitor against three receptor tyrosine kinases.

I. André, H. Sakurai, I. Saiki, 2009, Bioorganic & medicinal chemistry letters.

Tumor necrosis factor-alpha-induced IKK phosphorylation of NF-kappaB p65 on serine 536 is mediated through the TRAF2, TRAF5, and TAK1 signaling pathway.

Takahiro Doi, Hiroaki Sakurai, H. Nakano, 2003, The Journal of biological chemistry.

TAK1-Mediated Serine/Threonine Phosphorylation of Epidermal Growth Factor Receptor via p38/Extracellular Signal-Regulated Kinase: NF-κB-Independent Survival Pathways in Tumor Necrosis Factor Alpha Signaling

H. Sakurai, I. Saiki, K. Koizumi, 2009, Molecular and Cellular Biology.

DT‐5461, a New Synthetic Lipid A Analogue, Inhibits Lung and Liver Metastasis of Tumor in Mice

Katsuaki Sato, Y. Yoo, I. Saiki, 1992, Japanese journal of cancer research : Gann.

Activation by synthetic lipid A subunit analogues (GLA compounds) of tumoricidal properties in human blood monocytes.

I. Saiki, H. Maeda, M. Kiso, 1990, Vaccine.

Production of interleukin 1 from human monocytes stimulated by synthetic lipid A subunit analogues.

I. Saiki, H. Maeda, J. Murata, 1990, International journal of immunopharmacology.

Effects of traditional Japanese (Kampo) medicines (orengedokuto, goreisan and shichimotsukokato) on the onset of stroke and expression patterns of plasma proteins in spontaneously hypertensive stroke-prone rats

H. Sakurai, I. Saiki, Kazuko Hayashi, 2008 .

An intestinal bacterial metabolite of ginseng protopanaxadiol saponins has the ability to induce apoptosis in tumor cells.

I Saiki, I. Saiki, J. Murata, 1998, Biochemical and biophysical research communications.

Survivin suppression through STAT3/β-catenin is essential for resveratrol-induced melanoma apoptosis.

H. Sakurai, I. Saiki, S. Awale, 2014, International journal of oncology.

Uptake and accumulation of the vital dye hydroethidine in neoplastic cells.

C. Bucana, I. Saiki, R. Nayar, 1986, The journal of histochemistry and cytochemistry : official journal of the Histochemistry Society.

A microassay for the rapid and selective binding of cells from solid tumors to mouse macrophages

C. Bucana, I. Fidler, I. Saiki, 1986, Cancer Immunology and Immunotherapy.

Coptidis Rhizoma induces intrinsic apoptosis through BAX and BAK activation in human melanoma.

I. Saiki, S. Yokoyama, Y. Hayakawa, 2017, Oncology reports.

Role of chemokine CX3CL1 in progression of multiple myeloma via CX3CR1 in bone microenvironments.

K. Tsuneyama, T. Sugiyama, H. Sakurai, 2015, Oncology reports.

Inverse correlation between Thr‐669 and constitutive tyrosine phosphorylation in the asymmetric epidermal growth factor receptor dimer conformation

H. Sakurai, I. Saiki, K. Koizumi, 2013, Cancer science.

Increased surgical stress promotes tumor metastasis.

I. Saiki, K. Tsukada, S. Sawada, 2003, Surgery.

Staminolactones A and B and norstaminol A: three highly oxygenated staminane-type diterpenes from Orthosiphon stamineus.

I. Saiki, S. Kadota, Y. Tezuka, 1999, Organic letters.

An amazing cow's urine therapy practice in Myanmar(News Letter)

I. Saiki, S. Awale, T. Linn, 2006 .

The healing art of traditional medicines in Myanmar

I. Saiki, S. Kadota, S. Awale, 2006 .

Crucial roles of RSK in cell motility by catalysing serine phosphorylation of EphA2

H. Sakurai, S. Yano, I. Saiki, 2015, Nature Communications.

Regulatory effects on macrophages of human recombinant interferons-alpha.

W. Koff, I. Saiki, A. Fann, 1986, Journal of interferon research.

Blockade of transforming growth factor-β-activated kinase 1 activity enhances TRAIL-induced apoptosis through activation of a caspase cascade

S. Akira, Shintaro Sato, H. Sakurai, 2006, Molecular Cancer Therapeutics.

Regulation of activator protein-1 activity in the mediastinal lymph node metastasis of lung cancer

I. Saiki, N. Mitani, Y. Doki, 2004, Clinical & Experimental Metastasis.

Selective anticancer activity of hirsutine against HER2‑positive breast cancer cells by inducing DNA damage.

I. Saiki, S. Yokoyama, Y. Hayakawa, 2015, Oncology reports.

Role of the CXCL12/CXCR4 axis in peritoneal carcinomatosis of gastric cancer.

H. Sakurai, I. Saiki, K. Koizumi, 2006, Cancer Research.

IL‐17A‐producing CD30+ Vδ1 T cells drive inflammation‐induced cancer progression

T. Irimura, Y. Iwakura, I. Saiki, 2016, Cancer science.

Mammary tissue microenvironment determines T cell-dependent breast cancer-associated inflammation

K. Tsuneyama, T. Irimura, I. Saiki, 2015, Cancer science.

Mesenchymal-transitioned cancer cells instigate the invasion of epithelial cancer cells through secretion of WNT3 and WNT5B

H. Sakurai, I. Saiki, S. Yokoyama, 2014, Cancer science.

Morphine analgesia suppresses tumor growth and metastasis in a mouse model of cancer pain produced by orthotopic tumor inoculation.

H. Nojima, I. Saiki, J. Murata, 2002, European journal of pharmacology.

Identification of a predictive biomarker for the beneficial effect of a Kampo (Japanese traditional) medicine keishibukuryogan in rheumatoid arthritis patients.

H. Sakurai, I. Saiki, K. Koizumi, 2007, Clinical biochemistry.

Inhibition of tumor invasion and metastasis by calciumspirulan (Ca-SP), a novel sulfated polysaccharide derived from a blue-green alga, Spirulina platensis

M. Nakajima, I. Saiki, J. Murata, 1998, Clinical & Experimental Metastasis.

Antimetastatic effects of synthetic polypeptides containing repeated structures of the cell adhesive Arg-Gly-Asp (RGD) and Tyr-Ile-Gly-Ser-Arg (YIGSR) sequences.

I. Saiki, T. Sakurai, J. Murata, 1989, British Journal of Cancer.

Pharmacological evaluation of morphine and non-opioid analgesic adjuvants in a mouse model of skin cancer pain.

H. Nojima, I. Saiki, M. Fujita, 2008, Biological & pharmaceutical bulletin.

NK Cells Control Tumor-Promoting Function of Neutrophils in Mice

Y. Iwakura, Seiji Yamamoto, I. Saiki, 2018, Cancer Immunology Research.

Suppression by gabapentin of pain-related mechano-responses in mice given orthotopic tumor inoculation.

H. Nojima, I. Saiki, J. Murata, 2003, Biological & pharmaceutical bulletin.

Mechanical hypersensitivity and alterations in cutaneous nerve fibers in a mouse model of skin cancer pain.

H. Nojima, I. Saiki, J. Murata, 2003, Journal of pharmacological sciences.

Algogenic Effects of the Extract of the Tumor Mass Isolated from Mice with Orthotopic Melanoma Inoculation

H. Nojima, I. Saiki, J. Murata, 2001 .

Hepatoprotective effect of Combretum quadrangulare and its constituents.

I. Saiki, K. Hase, Q. Xiong, 2000, Biological & pharmaceutical bulletin.

Procyanidin C 1 from Cinnamomi Cortex inhibits TGF-β-induced epithelial-to-mesenchymal transition in the A 549 lung cancer cell line

H. Sakurai, I. Saiki, Ken Tanaka, 2013 .

A flavonoid chrysin suppresses hypoxic survival and metastatic growth of mouse breast cancer cells.

Hiroaki Sakurai, Somsak Ruchirawat, Suresh Awale, 2013, Oncology reports.

SRT1720, a SIRT1 activator, promotes tumor cell migration, and lung metastasis of breast cancer in mice.

H. Sakurai, K. Tobe, I. Usui, 2012, Oncology reports.

RAC1 inhibition as a therapeutic target for gefitinib-resistant non-small-cell lung cancer

Hiroaki Sakurai, Shinichiro Kato, H. Sakurai, 2014, Cancer science.

Novel inhibitor for fibroblast growth factor receptor tyrosine kinase.

H. Sakurai, I. Saiki, O. Vajragupta, 2007, Bioorganic & medicinal chemistry letters.

Lead compound bearing caffeic scaffold induces EGFR suppression in solid tumor cancer cells

I. Saiki, O. Vajragupta, S. Yokoyama, 2015 .

Inhibitory effect of Moutan Cortex aqueous fraction on mast cell-mediated allergic inflammation

Ji-Ye Kee, H. Sakurai, I. Saiki, 2015, Journal of Natural Medicines.

Roles of kinin B1 and B2 receptors in skin cancer pain produced by orthotopic melanoma inoculation in mice

I. Saiki, M. Fujita, Y. Kuraishi, 2010, European journal of pain.

Transient Suppression of Ligand-mediated Activation of Epidermal Growth Factor Receptor by Tumor Necrosis Factor-α through the TAK1-p38 Signaling Pathway*

Hiroaki Sakurai, H. Sakurai, I. Saiki, 2007, Journal of Biological Chemistry.

Adjuvant activity of carbohydrate analogs of N-acetylmuramyl-L-alanyl-D-isoglutamine on the induction of delayed-type hypersensitivity to azobenzenearsonate-N-acetyl-L-tyrosine in guinea pigs

I. Saiki, M. Kiso, A. Hasegawa, 1981, Infection and immunity.

A Proteomic Approach for the Diagnosis of ‘Oketsu’ (blood stasis), a Pathophysiologic Concept of Japanese Traditional (Kampo) Medicine

H. Sakurai, I. Saiki, K. Koizumi, 2007, Evidence-based complementary and alternative medicine : eCAM.

TAK1 promotes cell survival by TNFAIP3 and IL-8 dependent and NF-κB independent pathway in HeLa cells exposed to heat stress

Y. Tabuchi, Qing‐Li Zhao, T. Kondo, 2013, International journal of hyperthermia : the official journal of European Society for Hyperthermic Oncology, North American Hyperthermia Group.

TGF-β-Activated Kinase 1 Promotes Cell Cycle Arrest and Cell Survival of X-Ray Irradiated HeLa Cells Dependent on p21 Induction but Independent of NF-κB, p38 MAPK and ERK Phosphorylations

Y. Tabuchi, Qing‐Li Zhao, T. Kondo, 2012, Radiation research.

To elucidate individual pathogenic alteration (so-called "Sho") diagnosed by Kampo medicine -Evidence-based objective evaluation of the efficacy of Kampo formulations-

I. Saiki, 2009 .

Juzentaihoto, a Kampo medicine, enhances IL-12 production by modulating Toll-like receptor 4 signaling pathways in murine peritoneal exudate macrophages.

H. Sakurai, M. Choo, I. Saiki, 2005, International immunopharmacology.

Human T Cell Lymphotropic Virus 1 Manipulates Interferon Regulatory Signals by Controlling the TAK1-IRF3 and IRF4 Pathways*

Y. Tabuchi, I. Takasaki, S. Yamaoka, 2009, The Journal of Biological Chemistry.

AKT-STAT3 Pathway as a Downstream Target of EGFR Signaling to Regulate PD-L1 Expression on NSCLC cells

I. Saiki, S. Yokoyama, Y. Hayakawa, 2016, Journal of Cancer.

ZD1839, a selective epidermal growth factor receptor tyrosine kinase inhibitor, shows antimetastatic activity using a hepatocellular carcinoma model.

Hiroaki Sakurai, H. Sakurai, I. Saiki, 2003, Molecular cancer therapeutics.

Inhibition of tumor‐induced angiogenesis by the administration of recombinant interferon‐γ followed by a synthetic lipid‐a subunit analogue (GLA‐60)

Katsuaki Sato, Y. Yoo, I. Saiki, 1992, International journal of cancer.

Heregulin‐induced activation of ErbB3 by EGFR tyrosine kinase activity promotes tumor growth and metastasis in melanoma cells

Hiroaki Sakurai, Keiichi Koizumi, H. Sakurai, 2008, International journal of cancer.

Recombinant Fusion Polypeptide with Cell‐ and Heparin‐binding Domains of Fibronectin Inhibits Liver Metastasis of L5178Y‐ML25 Lymphoma Cells

I. Saiki, J. Murata, I. Azuma, 1991, Japanese journal of cancer research : Gann.

A new pseudo-peptide analogue of the Arg-Gly-Asp (RGD) sequence inhibits liver metastasis of colon 26-L5 carcinoma cells.

I. Saiki, M. Fujimaki, K. Tsukada, 1998, Cancer letters.

Cell adhesion molecules and cancer metastasis.

I. Saiki, 1997, Japanese journal of pharmacology.

Modulation of haptotactic migration of metastatic melanoma cells by the interaction between heparin and heparin-binding domain of fibronectin.

I. Saiki, J. Murata, I. Azuma, 1990, The Journal of biological chemistry.

Inhibition of tumor angiogenesis by a synthetic cell-adhesive polypeptide containing the Arg-Gly-Asp (RGD) sequence of fibronectin, poly(RGD).

I. Saiki, J. Murata, I. Azuma, 1990, Japanese journal of cancer research : Gann.

Anti-metastatic and anti-invasive effects of polymeric Arg-Gly-Asp (RGD) peptide, poly(RGD), and its analogues.

I. Saiki, J. Murata, I. Azuma, 1990, Japanese journal of cancer research : Gann.

Critical Roles of Threonine 187 Phosphorylation in Cellular Stress-induced Rapid and Transient Activation of Transforming Growth Factor-β-activated Kinase 1 (TAK1) in a Signaling Complex Containing TAK1-binding Protein TAB1 and TAB2*

H. Sakurai, I. Saiki, Shunsuke Suzuki, 2005, Journal of Biological Chemistry.

Hepatoprotective Effect of Majonoside R2, the Major Saponin from Vietnamese Ginseng (Panax vietnamensis)

Q. K. Tran, I. Saiki, S. Kadota, 2002, Planta medica.

Severe pulmonary metastasis in obese and diabetic mice

H. Sakurai, M. Choo, I. Saiki, 2006, International journal of cancer.

Tumor invasion is inhibited by phosphorylated ascorbate via enrichment of intracellular vitamin C and decreasing of oxidative stress

I. Saiki, N. Nagao, N. Miwa, 2000, Journal of Cancer Research and Clinical Oncology.

Antitumor effects of synthetic VEGF-receptor binding antagonist, VGA1155.

T. Yamagishi, S. Nakaike, K. Samata, 2005, Anticancer research.

Fibroblast growth factor‐2‐induced host stroma reaction during initial tumor growth promotes progression of mouse melanoma via vascular endothelial growth factor A‐dependent neovascularization

H. Sakurai, I. Saiki, S. Tsunoda, 2007, Cancer science.

A new pseudo-peptide of Arg-Gly-Asp (RGD) inhibits intrahepatic metastasis of orthotopically implanted murine hepatocellular carcinoma.

I. Saiki, K. Tsukada, S. Sawada, 2002, International Journal of Oncology.

Synthesis and biological properties of partially modified retro and retro-inverso pseudo peptides of arg-gly-asp (RGD)

I. Saiki, J. Murata, I. Azuma, 1996 .

TAC-101 inhibits intrahepatic metastasis of orthotopically implanted murine hepatocellular carcinoma.

H. Sakurai, I. Saiki, S. J. Lee, 2003, Cancer letters.

Tumour-derived fibroblast growth factor-2 exerts lymphangiogenic effects through Akt/mTOR/p70S6kinase pathway in rat lymphatic endothelial cells.

H. Sakurai, I. Saiki, K. Koizumi, 2007, European journal of cancer.

Psychosocial stress enhances IgE‐mediated triphasic cutaneous reaction in mice: Antagonism by Yokukan‐san (a Kampo medicine) and diazepam

I. Saiki, K. Terasawa, H. Nagai, 2002 .

Juzen-taiho-to (Shi-Quan-Da-Bu-Tang): scientific evaluation and clinical applications.

I. Saiki, H. Yamada, 2005 .

Social isolation stress enhanced liver metastasis of murine colon 26-L5 carcinoma cells by suppressing immune responses in mice.

I. Saiki, J. Murata, K. Murakami, 2000, Life sciences.

Cinnamaldehyde and paeonol increase HIF-1α activity in proximal tubular epithelial cells under hypoxia

H. Sakurai, I. Saiki, K. Koizumi, 2011 .

Motility and Chemotaxis of Arginine-glycine-aspartic Acid , thereby Stimulating Cell Integrins to Permit Cells to Bind to Osteopontin Independently 1-containing β CD 44 Variants but not CD 44 s Cooperate with Updated

K. Tanaka, J. Sleeman, P. Herrlich, 1998 .

CD 44 Variants but not CD 44 s Cooperate with b 1-containing Integrins to Permit Cells to Bind to Osteopontin Independently of Arginine-glycine-aspartic Acid , thereby Stimulating Cell Motility and Chemotaxis 1

K. Tanaka, J. Sleeman, P. Herrlich, 1998 .

Calpain 1 and -2 play opposite roles in cord formation of lymphatic endothelial cells via eNOS regulation

H. Sakurai, I. Saiki, K. Koizumi, 2012, Human Cell.

A novel low molecular weight antagonist of vascular endothelial growth factor receptor binding: VGA1155.

Hajime Takashima, T. Yamagishi, S. Nakaike, 2003, Molecular cancer therapeutics.

CXCL16 suppresses liver metastasis of colorectal cancer by promoting TNF-α-induced apoptosis by tumor-associated macrophages

K. Tsuneyama, I. Takasaki, T. Irimura, 2014, BMC Cancer.

Structure, synthesis, and biological activity of a C-20 bisacetylenic alcohol from a marine sponge Callyspongia sp.

M. Ono, I. Saiki, K. Koizumi, 2013, Journal of natural products.

Antitumor immune activity by chemokine CX3CL1 in an orthotopic implantation of lung cancer model in vivo.

Ji-Ye Kee, H. Sakurai, I. Saiki, 2013, Molecular and clinical oncology.

Potential ability of morphine to inhibit the adhesion, invasion and metastasis of metastatic colon 26-L5 carcinoma cells.

H. Nojima, I. Saiki, K. Koizumi, 2002, Cancer letters.

Inhibition of lymphangiogenesis‐related properties of murine lymphatic endothelial cells and lymph node metastasis of lung cancer by the matrix metalloproteinase inhibitor MMI270

I. Saiki, K. Koizumi, E. S. Nakamura, 2004, Cancer science.

Anti-metastatic and anti-angiogenic activities of a new matrix metalloproteinase inhibitor, TN-6b.

H. Sakurai, I. Saiki, S. J. Lee, 2003, European journal of cancer.

Treatment of experimental lung metastasis with local thoracic irradiation followed by systemic macrophage activation with liposomes containing muramyl tripeptide.

I. Fidler, L. Milas, N. Hunter, 1986, Cancer research.

Effects of the ethyl acetate fraction of Spatholobi caulis on tumour cell aggregation and migration

S. Ryu, I. Saiki, N. Baek, 2003, Phytotherapy research : PTR.

Selective inhibition of TNF-α-induced activation of mitogen-activated protein kinases and metastatic activities by gefitinib

H. Sakurai, M. Choo, I. Saiki, 2005, British Journal of Cancer.

Gomisin A enhances tumor necrosis factor-α-induced G1 cell cycle arrest via signal transducer and activator of transcription 1-mediated phosphorylation of retinoblastoma protein.

H. Sakurai, I. Saiki, S. Yokoyama, 2012, Biological & pharmaceutical bulletin.

Proteomic identification of haptoglobin as a stroke plasma biomarker in spontaneously hypertensive stroke-prone rats.

H. Sakurai, I. Saiki, Kazuko Hayashi, 2008, Life sciences.

Expression patterns of plasma proteins in spontaneously diabetic rats after oral administration of a Kampo medicine, Hachimi-jio-gan, using SELDI ProteinChip platform.

H. Sakurai, I. Saiki, K. Koizumi, 2005, Biological & pharmaceutical bulletin.

Tolerance to the anti‐metastatic effect of lipopolysaccharide against liver metastasis in mice

Katsuaki Sato, I. Saiki, I. Azuma, 1996, International journal of cancer.

Berberine enhances tumor necrosis factor-related apoptosis-inducing ligand-mediated apoptosis in breast cancer

I. Saiki, H. Yagita, S. Yokoyama, 2013, Oncology letters.

Lethal toxicity and adjuvant activities of synthetic TDM and its related compounds in mice.

I. Saiki, T. Sakurai, I. Azuma, 1989, Vaccine.

Cross interference with TNF-alpha-induced TAK1 activation via EGFR-mediated p38 phosphorylation of TAK1-binding protein 1.

H. Sakurai, I. Saiki, K. Koizumi, 2009, Biochimica et biophysica acta.

Massive T-lymphocyte infiltration into the host stroma is essential for fibroblast growth factor-2-promoted growth and metastasis of mammary tumors via neovascular stability.

H. Sakurai, I. Saiki, Y. Ueno, 2009, The American journal of pathology.

Pharmacokinetics of ginsenoside deglycosylated by intestinal bacteria and its transformation to biologically active fatty acid esters.

I. Saiki, S. Kadota, Y. Tezuka, 2000, Biological & pharmaceutical bulletin.

Effect of hepatocyte growth factor on invasion of prostate cancer cell lines.

Y. Fujiuchi, H. Fuse, I. Saiki, 2003, Oncology reports.

Astilbin selectively induces dysfunction of liver-infiltrating cells--novel protection from liver damage.

I. Saiki, A. Koda, F. Wu, 1999, European journal of pharmacology.

Vasoactive intestinal peptide (VIP) enhances the cell motility of androgen receptor-transfected DU-145 prostate cancer cells (DU-145/AR).

T. Matsuda, Y. Fujiuchi, H. Fuse, 2002, Cancer letters.

Highly oxygenated antiausterity agents from the leaves of Uvaria dac.

H. Esumi, I. Saiki, Kinzo Matsumoto, 2017, Bioorganic & medicinal chemistry letters.

A phagocytotic inducer from herbal constituent, pentagalloylglucose enhances lipoplex-mediated gene transfection in dendritic cells.

S. Nakagawa, H. Sakurai, I. Saiki, 2010, Biological & pharmaceutical bulletin.

Model for mediastinal lymph node metastasis produced by orthotopic intrapulmonary implantation of lung cancer cells in mice.

I. Saiki, K. Murakami, T. Yamaura, 1999, Human cell.

Identification of plant extracts sensitizing breast cancer cells to TRAIL.

I. Saiki, S. Awale, S. Yokoyama, 2013, Oncology reports.

Cell‐surface sulfoglycolipids are involved in the attachment of renal‐cancer cells to laminin

Takahiko Kobayashi, K. Honke, I. Saiki, 1994, International journal of cancer.

Helicobacter pylori Induces Serine Phosphorylation of EGFR via Novel TAK1–p38 Activation Pathway in an HB‐EGF‐Independent Manner

T. Sugiyama, H. Sakurai, I. Saiki, 2015, Helicobacter.

Role of the heparin-binding domain of chimeric peptides derived from fibronectin in cell spreading and motility.

H. Kobayashi, I. Saiki, I. Azuma, 1995, Experimental cell research.

Clinical Application of Juzentaihoto for Skin Diseases and its Possible Mechanism

I. Saiki, K. Terasawa, N. Sekiya, 2008 .

Inhibitory Effect of a Traditional Chinese Medicine, Juzen‐taiho‐to, on Progressive Growth of Weakly Malignant Clone Cells Derived from Murine Fibrosarcoma

I. Saiki, J. Murata, M. Fujimaki, 1996, Japanese journal of cancer research : Gann.

Accumulation of extracellular matrix in the liver induces high metastatic potential of hepatocellular carcinoma to the lung.

I. Saiki, J. Murata, K. Tsukada, 2001, International journal of oncology.

Herbal plant‐derived compound, 1,2,3,4,6‐penta‐O‐galloyl‐β‐d‐glucose, increases cross‐presentation by dendritic cells

H. Sakurai, I. Saiki, K. Koizumi, 2015 .

Psychosocial Stress Augments Tumor Development through β‐Adrenergic Activation in Mice

I. Saiki, H. Hasegawa, 2002, Japanese journal of cancer research : Gann.

Gomisin N enhances TNF-α-induced apoptosis via inhibition of the NF-κB and EGFR survival pathways

H. Sakurai, I. Saiki, K. Koizumi, 2011, Molecular and Cellular Biochemistry.

Inhibitory effect of a synthetic polypeptide, poly(Tyr-Ile-Gly-Ser-Arg), on the metastatic formation of malignant tumour cells.

I. Saiki, J. Murata, I. Azuma, 1989, International journal of biological macromolecules.

An intestinal bacterial metabolite (M1) of ginseng protopanaxadiol saponins inhibits tumor-induced neovascularization.

I. Saiki, J. Murata, K. Murakami, 2000 .

Involvement of insulin-like growth factor binding protein-3 in the retinoic acid receptor-alpha-mediated inhibition of hepatocellular carcinoma cell proliferation.

I. Saiki, T. Matsuura, K. Murakami, 2000, Cancer letters.

Enzymatic and biochemical properties of a novel human serine dehydratase isoform.

H. Pitot, H. Ochiai, H. Sakurai, 2006, Biochimica et biophysica acta.

Chemical synthesis and adjuvant activity of N-acetylmuramyl-L-alanyl-D-isoglutamine (MDP) analogs.

I. Saiki, I. Azuma, Y. Tanio, 1981 .

Inhibition of Tumor‐induced Angiogenesis by a Synthetic Lipid A Analogue with Low Endotoxicity, DT‐5461

Katsuaki Sato, Y. Yoo, I. Saiki, 1995, Japanese journal of cancer research : Gann.

Biological activities of synthetic polypeptides containing a repetitive core sequence (Arg-Gly-Asp) of cell adhesion molecules.

I. Saiki, J. Iida, I. Azuma, 1989, International journal of biological macromolecules.

Bioimaging of Fluorescence-Labeled Mitochondria in Subcutaneously Grafted Murine Melanoma Cells by the “In Vivo Cryotechnique”

I. Saiki, Bao Wu, Y. Saitoh, 2014, The journal of histochemistry and cytochemistry : official journal of the Histochemistry Society.

Inhibitory effects of caffeic acid phenethyl ester analogues on experimental lung metastasis of murine colon 26-L5 carcinoma cells.

I. Saiki, S. Kadota, K. Koizumi, 2003, Biological & pharmaceutical bulletin.

Muramyl Dipeptide Derivatives with Multiprenylacetyl Group. Synthesis and Immunological Activities

I. Saiki, I. Azuma, M. Fujino, 1981 .

Microdialysis assessment of 5-fluorouracil release from thermosensitive magnetoliposomes induced by an electromagnetic field in tumor-bearing mice.

I. Saiki, J. Murata, E. Viroonchatapan, 1998, Journal of drug targeting.

Comparison of two Kampo medicines in a diet‐induced mouse obesity model

K. Tsuneyama, I. Saiki, S. Yokoyama, 2015 .

In tumor-bearing mice.

I. Saiki, Y. Tanio, Y. Yamamura, 1983 .

Port-site metastasis after CO2 pneumoperitoneum

S. Kitano, I. Saiki, N. Shiraishi, 2004, Surgical Endoscopy And Other Interventional Techniques.

Port-site metastasis after CO2 pneumoperitoneum: role of adhesion molecules and prevention with antiadhesion molecules.

S. Kitano, I. Saiki, N. Shiraishi, 2004, Surgical endoscopy.

Overexpression of retinoic acid receptor alpha in hepatocellular carcinoma.

M. Makuuchi, T. Takayama, I. Saiki, 2003, Clinical cancer research : an official journal of the American Association for Cancer Research.

Constitutive Activation of TAK1 by HTLV-1 Tax-dependent Overexpression of TAB2 Induces Activation of JNK-ATF2 but Not IKK-NF-κB*

S. Yamaoka, H. Sakurai, I. Kitajima, 2007, Journal of Biological Chemistry.

( + )-Grandifloracin, an antiausterity agent, induces autophagic Panc-1 pancreatic cancer cell death

R. Miyatake, I. Saiki, S. Awale, 2013 .

( + )-Grandifloracin, an antiausterity agent, induces autophagic Panc-1 pancreatic cancer cell death

R. Miyatake, I. Saiki, S. Awale, 2013 .

( + )-Grandifloracin, an antiausterity agent, induces autophagic Panc-1 pancreatic cancer cell death

R. Miyatake, I. Saiki, S. Awale, 2013 .

( + )-Grandifloracin, an antiausterity agent, induces autophagic Panc-1 pancreatic cancer cell death

R. Miyatake, I. Saiki, S. Awale, 2013 .

Social isolation stress augments angiogenesis induced by colon 26-L5 carcinoma cells in mice

I. Saiki, J. Murata, Wenjuan Wu, 2004, Clinical & Experimental Metastasis.

Helicobacter pylori Induces Serine Phosphorylation of EGFR via Novel TAK1–p38 Activation Pathway in an HB‐EGF‐Independent Manner

T. Sugiyama, H. Sakurai, I. Saiki, 2015, Helicobacter.

This information is current as Costimulatory Pathways Functions of NKT Cells by CD 28 and CD 40 Differential Regulation of Th 1 and Th 2

L. Kaer, I. Saiki, K. Okumura, 2001 .

Selective anticancer activity of hirsutine against HER2‑positive breast cancer cells by inducing DNA damage.

I. Saiki, S. Yokoyama, Y. Hayakawa, 2015, Oncology reports.

Roles of kinin B1 and B2 receptors in skin cancer pain produced by orthotopic melanoma inoculation in mice

I. Saiki, M. Fujita, Y. Kuraishi, 2010, European journal of pain.

High-level expression of chemokine CXCL16 by tumor cells correlates with a good prognosis and increased tumor-infiltrating lymphocytes in colorectal cancer.

K. Tsuneyama, Y. Takano, H. Sakurai, 2007, Cancer research.

Ethanolic extract of Thevetia peruviana flowers enhances TNF-α and TRAIL-induced apoptosis of human cervical cancer cells via intrinsic and extrinsic pathways.

H. Sakurai, I. Saiki, C. Managit, 2017, Oncology letters.

Inverse correlation between Thr‐669 and constitutive tyrosine phosphorylation in the asymmetric epidermal growth factor receptor dimer conformation

H. Sakurai, I. Saiki, K. Koizumi, 2013, Cancer science.

Differential effect of intestinal neuropeptides on invasion and migration of colon carcinoma cells in vitro.

I. Saiki, J. Murata, M. Ogasawara, 1997, Cancer letters.

Abyssomicin I, a modified polycyclic polyketide from Streptomyces sp. CHI39.

H. Sakurai, I. Saiki, Y. Igarashi, 2010, Journal of natural products.

5-Substituted pyrido[2,3-d]pyrimidine, an inhibitor against three receptor tyrosine kinases.

I. André, H. Sakurai, I. Saiki, 2009, Bioorganic & medicinal chemistry letters.

Serum active hepatocyte growth factor (AHGF) in benign prostatic disease and prostate cancer

Y. Fujiuchi, I. Saiki, K. Koizumi, 2009, The Prostate.

Synthesis and Biological Evaluation of Macrosphelide Cores

H. Sakurai, I. Saiki, Kentaro Ishihara, 2004 .

p38‐Mediated phosphorylation of Eps15 endocytic adaptor protein

Y. Ishihama, T. Sakuma, H. Sakurai, 2014, FEBS letters.