R. Guo

发表

Novel strategies for the treatment of sepsis

Peter A. Ward, P. Ward, N. Riedemann, 2003, Nature Medicine.

Regulation by C5a of neutrophil activation during sepsis.

P. Ward, N. Riedemann, R. Guo, 2003, Immunity.

The enigma of sepsis.

P. Ward, N. Riedemann, R. Guo, 2003, The Journal of clinical investigation.

Role of C5a in inflammatory responses.

P. Ward, R. Guo, Peter A Ward, 2005, Annual review of immunology.

Role of C 5 a in Multiorgan Failure During Sepsis 1

P. Ward, M. Huber-Lang, R. Guo, 2000 .

Role of C5a in Multiorgan Failure During Sepsis1

P. Ward, M. Huber-Lang, R. Guo, 2001, The Journal of Immunology.

Complement-Induced Impairment of Innate Immunity During Sepsis1

J. V. Sarma, P. Ward, M. Huber-Lang, 2002, The Journal of Immunology.

The FASEB Journal express article 10.1096/fj.02-0033fje. Published online April 23, 2002. C5a receptor and thymocyte apoptosis in sepsis

N. Riedemann, R. Guo, Ines J. Laudes, 2022 .

Anti-c5a ameliorates coagulation/fibrinolytic protein changes in a rat model of sepsis.

A. Schmaier, J. V. Sarma, P. Ward, 2002, The American journal of pathology.

Regulatory Role of C5a on Macrophage Migration Inhibitory Factor Release from Neutrophils1

P. Ward, Lei Sun, N. Riedemann, 2004, The Journal of Immunology.

Stat3 Activation in Acute Lung Injury1

J. V. Sarma, P. Ward, N. Van Rooijen, 2004, The Journal of Immunology.

Protective effects of anti-C5a in sepsis-induced thymocyte apoptosis.

P. Ward, M. Huber-Lang, N. Riedemann, 2000, The Journal of clinical investigation.

The role of C5a in acute lung injury induced by highly pathogenic viral infections

Yan Li, B. Shen, R. Guo, 2015, Emerging Microbes & Infections.

The promoting effect of tumour necrosis factor alpha in radiation-induced cell transformation.

R. Guo, Y. Gong, RF Guo, 1998, British Journal of Cancer.

Attenuation of IgG immune complex‐induced acute lung injury by silencing C5aR in lung epithelial cells

J. V. Sarma, P. Ward, Lei Sun, 2009, FASEB journal : official publication of the Federation of American Societies for Experimental Biology.

Disturbed homeostasis of lung intercellular adhesion molecule-1 and vascular cell adhesion molecule-1 during sepsis.

J. V. Sarma, P. Ward, N. Riedemann, 2004, The American journal of pathology.

Role of CC Chemokines (Macrophage Inflammatory Protein-1β, Monocyte Chemoattractant Protein-1, RANTES) in Acute Lung Injury in Rats1

A. Lentsch, P. Ward, M. Huber-Lang, 2000, The Journal of Immunology.

Role of oxidants in lung injury during sepsis.

P. Ward, R. Guo, 2007, Antioxidants & redox signaling.

Blockade of the C5a–C5aR axis alleviates lung damage in hDPP4-transgenic mice infected with MERS-CoV

Shibo Jiang, R. Guo, L. Du, 2018, Emerging Microbes & Infections.

Treatment of Paraquat-Induced Lung Injury With an Anti-C5a Antibody: Potential Clinical Application*

Yan Li, Shibo Jiang, Xiaoling Liu, 2018, Critical care medicine.

Vesicants and oxidative stress.

B. Lukey, P. Ward, R. Guo, 2008 .

Neutrophil infiltration favors colitis-associated tumorigenesis by activating the interleukin-1 (IL-1)/IL-6 axis

Y. Wang, Yan Li, B. Shen, 2014, Mucosal Immunology.

Divergent Signaling Pathways in Phagocytic Cells during Sepsis1

P. Ward, Lei Sun, N. Riedemann, 2006, Journal of Immunology.

The protumorigenic potential of FTY720 by promoting extramedullary hematopoiesis and MDSC accumulation

Y. Ma, R. Guo, G. Han, 2017, Oncogene.

Mediators and regulation of neutrophil accumulation in inflammatory responses in lung: insights from the IgG immune complex model.

P. Ward, R. Guo, 2002, Free radical biology & medicine.

Tristetraprolin (TTP)-14-3-3 Complex Formation Protects TTP from Dephosphorylation by Protein Phosphatase 2a and Stabilizes Tumor Necrosis Factor-α mRNA*

Lei Sun, T. Shanley, R. Guo, 2006, Journal of Biological Chemistry.

Altered Neutrophil Trafficking During Sepsis1

J. Paulauskis, P. Ward, N. Riedemann, 2002, The Journal of Immunology.

Altered Neutrophil Trafficking During Sepsis

Sarma, N. Riedemann, R. Guo, 2002 .

Anti-inflammatory effects of mutant forms of secretory leukocyte protease inhibitor.

A. Lentsch, P. Ward, M. Huber-Lang, 2000, The American journal of pathology.

Exogenous nitric oxide donor and related compounds protect against lung inflammatory response after hemorrhagic shock and resuscitation.

L. Toledo-Pereyra, P. Ward, R. Guo, 2004, The Journal of trauma.

The Attenuation of Hemorrhage-Induced Liver Injury by Exogenous Nitric Oxide, L -Arginine, and Inhibition of Inducible Nitric Oxide Synthase

L. Toledo-Pereyra, P. Ward, R. Guo, 2003, Journal of investigative surgery : the official journal of the Academy of Surgical Research.

Activator protein-1 activation in acute lung injury.

A. Lentsch, J. V. Sarma, P. Ward, 2002, The American journal of pathology.

Eotaxin expression in Sephadex-induced lung injury in rats.

P. Ward, M. Huber-Lang, R. Guo, 1999, The American journal of pathology.

Expression and Function of the C5a Receptor in Rat Alveolar Epithelial Cells1

P. Ward, M. Huber-Lang, N. Riedemann, 2002, The Journal of Immunology.

Expression and Function of the C5a Receptor in Rat Alveolar Epithelial Cells

P. Ward, M. Huber-Lang, R. Guo, 2002 .

Complement C5a regulates IL‐17 by affecting the crosstalk between DC and γδ T cells in CLP‐induced sepsis

Yan Li, B. Shen, R. Guo, 2010, European journal of immunology.

Regulation of IL-8 production by complement-activated product, C5a, in vitro and in vivo during sepsis.

Xia Li, Xinying Li, Yan Li, 2010, Clinical immunology.

Regulatory Effects of Eotaxin on Acute Lung Inflammatory Injury

A. Lentsch, J. V. Sarma, P. Ward, 2001, The Journal of Immunology.

Inflammatory Injury Regulatory Effects of Eotaxin on Acute Lung

A. Lentsch, J. V. Sarma, P. Ward, 2001 .

Cells during Sepsis Divergent Signaling Pathways in Phagocytic

Lei Sun, N. Riedemann, R. Guo, 2006 .

Mediators of Lung Inflammation: Role of Reactive Oxygen and Nitrogen Species

P. Ward, R. Guo, J. Reuben, 2004 .

Evidence for a functional role of the second C5a receptor C5L2

S. Tomlins, J. V. Sarma, N. Riedemann, 2005, FASEB journal : official publication of the Federation of American Societies for Experimental Biology.

Regulatory effects of iNOS on acute lung inflammatory responses in mice.

J. V. Sarma, P. Ward, N. Riedemann, 2003, The American journal of pathology.

The Phosphatidylinositol 3-Kinase Signaling Pathway Exerts Protective Effects during Sepsis by Controlling C5a-Mediated Activation of Innate Immune Functions1

C. Krettek, D. Kendoff, P. Ward, 2007, The Journal of Immunology.

The Phosphatidylinositol 3-Kinase Signaling Pathway Exerts Protective Effects during Sepsis by Controlling C5a-Mediated Activation of Innate Immune Functions

C. Krettek, D. Kendoff, N. Riedemann, 2007 .

Activation of Innate Immune Functions Sepsis by Controlling C 5 a-Mediated Pathway Exerts Protective Effects during The Phosphatidylinositol 3-Kinase Signaling

C. Krettek, D. Kendoff, P. Ward, 2007 .

Increased C5a receptor expression in sepsis.

John D Lambris, J. Lambris, P. Ward, 2002, The Journal of clinical investigation.

Role of RANTES in experimental cardiac allograft rejection.

P. Ward, T. Shanley, R. Guo, 2000, Experimental and molecular pathology.

Acute Lung Injury in Rats Chemoattractant Protein-1, RANTES) in , Monocyte b Inflammatory Protein-1 Role of CC Chemokines (Macrophage

A. Lentsch, P. Ward, M. Huber-Lang, 2000 .

Anti-complement Strategies in Experimental Sepsis

J. V. Sarma, P. Ward, M. Huber-Lang, 2003, Scandinavian journal of infectious diseases.

Protective effects of anti‐C5a peptide antibodies in experimental sepsis

J. Younger, J. V. Sarma, P. Ward, 2001, FASEB journal : official publication of the Federation of American Societies for Experimental Biology.

Regulatory role of C5a in LPS‐induced IL‐6 production by neutrophils during sepsis

J. V. Sarma, P. Ward, N. Riedemann, 2004, FASEB journal : official publication of the Federation of American Societies for Experimental Biology.

A Second Stimulus Required for Enhanced Antifungal Activity of Human Neutrophils in Blood Is Provided by Anaphylatoxin C5a

M. Figge, Teresa Lehnert, Kerstin Hünniger, 2015, The Journal of Immunology.

Anaphylatoxin C 5 a Antifungal Activity of Human Neutrophils in A Second Stimulus Required for Enhanced

M. Figge, Kerstin Hünniger, N. Riedemann, 2014 .

Sepsis in Humans (C5L2), during Experimental Sepsis and Changes in the Novel Orphan, C5a Receptor

P. Monk, J. V. Sarma, D. Rittirsch, 2004 .

Neutrophil C5a receptor and the outcome in a rat model of sepsis

J. Paulauskis, P. Ward, N. Riedemann, 2003, FASEB journal : official publication of the Federation of American Societies for Experimental Biology.

Manipulation of the Complement System for Benefit in Sepsis

P. Ward, N. Riedemann, R. Guo, 2012, Critical care research and practice.

ExpressionLinked to Reduced C5a Receptor Protective Effects of IL-6 Blockade in Sepsis

J. V. Sarma, P. Ward, R. Guo, 2013 .

An epithelial-to-mesenchymal transition-inducing potential of granulocyte macrophage colony-stimulating factor in colon cancer

Hui Peng, Yan Li, B. Shen, 2017, Scientific Reports.

Colitogenic role of tumour necrosis factor (TNF) receptors in trinitrobenzene sulphonic acid colitis: TNF‐R1 ablation does not affect systemic inflammatory response

Y. Li, Y. Wang, B. Shen, 2011, Clinical and experimental immunology.

Immunity During Sepsis Complement-Induced Impairment of Innate Erickson and

J. V. Sarma, P. Ward, M. Huber-Lang, 2002 .

Controlling the anaphylatoxin C5a in diseases requires a specifically targeted inhibition.

N. Riedemann, R. Guo, Jana Ziereisen, 2017, Clinical immunology.

Molecular cloning and characterization of a novel human CC chemokine, SCYA26.

P. Ward, M. Huber-Lang, R. Guo, 1999, Genomics.

In vivo regulation of neutrophil apoptosis by C5a during sepsis

D. Rittirsch, P. Ward, Lei Sun, 2006, Journal of leukocyte biology.

Effect of IL-10 on neutrophil recruitment and survival after Pseudomonas aeruginosa challenge.

T. Standiford, Lei Sun, T. Shanley, 2009, American journal of respiratory cell and molecular biology.

Regulatory effects of interleukin‐11 during acute lung inflammatory injury

A. Lentsch, R. Guo, V. Sarma, 1999, Journal of leukocyte biology.

Adenoviral-Mediated Overexpression of SOCS3 Enhances IgG Immune Complex-Induced Acute Lung Injury1

J. V. Sarma, P. Ward, R. Guo, 2006, The Journal of Immunology.

Clinical efficacy of complement C5a inhibition by IFX‐1 in hidradenitis suppurativa: an open‐label single‐arm trial in patients not eligible for adalimumab

M. Argyropoulou, N. Riedemann, R. Guo, 2020, The British journal of dermatology.

Interleukin‐17‐producing γδ+ T cells protect NOD mice from type 1 diabetes through a mechanism involving transforming growth factor‐β

Yan Li, B. Shen, R. Guo, 2010, Immunology.

Relationship of acute lung inflammatory injury to Fas/FasL system.

J. V. Sarma, P. Ward, M. Huber-Lang, 2005, The American journal of pathology.

Complement activation promotes colitis-associated carcinogenesis through activating intestinal IL-1β/IL-17A axis

R. Guo, Y. Wang, G. Han, 2015, Mucosal Immunology.

Molecular Cloning and Characterization of DEFCAP-L and -S, Two Isoforms of a Novel Member of the Mammalian Ced-4 Family of Apoptosis Proteins*

P. Ward, R. Guo, C. Vincenz, 2001, The Journal of Biological Chemistry.

Protective Effects of IL-6 Blockade in Sepsis Are Linked to Reduced C5a Receptor Expression1

John D Lambris, J. Lambris, J. V. Sarma, 2003, The Journal of Immunology.

Adenovirus-Mediated In Vivo Silencing of Anaphylatoxin Receptor C5aR

P. Ward, Lei Sun, R. Guo, 2006, Journal of biomedicine & biotechnology.

A key role of C5a/C5aR activation for the development of sepsis

N. Riedemann, R. Guo, P. Ward, 2003, Journal of leukocyte biology.

Regulatory T Cells Promote β-Catenin--Mediated Epithelium-to-Mesenchyme Transition During Radiation-Induced Pulmonary Fibrosis.

P. Zhou, R. Guo, L. Du, 2015, International journal of radiation oncology, biology, physics.

Tumor-derived GM-CSF promotes inflammatory colon carcinogenesis via stimulating epithelial release of VEGF.

Xinying Li, Yan Li, B. Shen, 2014, Cancer research.

Microenvironment and Immunology Tumor-Derived GM-CSF Promotes In fl ammatory Colon Carcinogenesis via Stimulating Epithelial Release of VEGF

KeWang, Xinying Li, Yan Li, 2014 .

ROLE OF C5 AI NINFLAMMATORY RESPONSES

P. Ward, R. Guo, 2005 .

Protective role of tumor necrosis factor (TNF) receptors in chronic intestinal inflammation: TNFR1 ablation boosts systemic inflammatory response

Xinying Li, Yan Li, B. Shen, 2013, Laboratory Investigation.

A Role for CD54 (Intercellular Adhesion Molecule-1) in Leukocyte Recruitment to the Lung During the Development of Experimental Idiopathic Pneumonia Syndrome

P. Ward, E. Holler, R. Andreesen, 2005, Transplantation.

Spliceosome protein Eftud2 promotes colitis-associated tumorigenesis by modulating inflammatory response of macrophage

Xinying Li, Hui Peng, Yan Li, 2019, Mucosal Immunology.

Anti-C5a antibody IFX-1 (vilobelimab) treatment versus best supportive care for patients with severe COVID-19 (PANAMO): an exploratory, open-label, phase 2 randomised controlled trial

P. van Paassen, J. Horn, W. Wiersinga, 2020, The Lancet Rheumatology.

Changes in the Novel Orphan, C5a Receptor (C5L2), during Experimental Sepsis and Sepsis in Humans1

P. Monk, J. V. Sarma, D. Rittirsch, 2005, The Journal of Immunology.

Role of IL-18 in Acute Lung Inflammation1

G. Senaldi, P. Ward, R. Guo, 2001, The Journal of Immunology.

Blockade of complement activation product C5a activity using specific antibody attenuates intestinal damage in trinitrobenzene sulfonic acid induced model of colitis

Xinying Li, Yan Li, B. Shen, 2011, Laboratory Investigation.

Role of C5a–C5aR Interaction in Sepsis

Peter A. Ward, P. Ward, N. Riedemann, 2004, Shock.

Protection of innate immunity by C5aR antagonist in septic mice

John D Lambris, J. Lambris, J. V. Sarma, 2002, FASEB journal : official publication of the Federation of American Societies for Experimental Biology.

Identification of conformational core epitope Lys⁶⁸ in C5a based on the 3-D modeling complex C5a and its functional antibody F20.

Hui Peng, Yan Li, B. Shen, 2011, Molecular immunology.

Treatment With Anti-C5a Antibody Improves the Outcome of H7N9 Virus Infection in African Green Monkeys

Yan Li, Shibo Jiang, N. Riedemann, 2014, Clinical infectious diseases : an official publication of the Infectious Diseases Society of America.

Inhibition of complement activation alleviates acute lung injury induced by highly pathogenic avian influenza H5N1 virus infection.

Shibo Jiang, R. Guo, L. Du, 2013, American journal of respiratory cell and molecular biology.

Structure-Function Relationships of Human C 5 a and C 5 aR 1

E. Zuiderweg, J. V. Sarma, P. Ward, 2003 .

A role for complement in paraquat-induced acute lung injury

R. Guo, L. Du, Yusen Zhou, 2010 .

An epithelial-to-mesenchymal transition-inducing potential of granulocyte macrophage colony-stimulating factor in colon cancer

Hui Peng, Yan Li, B. Shen, 2017, Scientific Reports.

The anti‐C5a antibody vilobelimab efficiently inhibits C5a in patients with severe COVID‐19

P. van Paassen, N. Riedemann, R. Guo, 2022, Clinical and translational science.

Treg depletion attenuates irradiation-induced pulmonary fibrosis by reducing fibrocyte accumulation, inducing Th17 response, and shifting IFN-γ, IL-12/IL-4, IL-5 balance.

R. Guo, L. Du, F. Xiao, 2015, Immunobiology.

Anti-C5a Antibody (IFX-1) Treatment of Severe COVID-19: An Exploratory Phase 2 Randomized Controlled Trial

J. Horn, W. Wiersinga, N. Riedemann, 2020 .

C5a, a therapeutic target in sepsis.

P. Ward, R. Guo, 2006, Recent patents on anti-infective drug discovery.

Complex-Induced Acute Lung Injury SOCS3 Enhances IgG Immune Adenoviral-Mediated Overexpression of

J. V. Sarma, R. Guo, P. Ward, 2006 .

Early Intra-Articular Complement Activation in Ankle Fractures

N. Riedemann, R. Guo, H. Schmal, 2014, BioMed research international.

Expression and Function of C5a Receptor in Mouse Microvascular Endothelial Cells1

John D Lambris, J. Lambris, J. V. Sarma, 2002, The Journal of Immunology.

Opposite Role of Tumor Necrosis Factor Receptors in Dextran Sulfate Sodium-Induced Colitis in Mice

Xinying Li, Yan Li, B. Shen, 2012, PloS one.

Transforming growth factor β3 attenuates the development of radiation-induced pulmonary fibrosis in mice by decreasing fibrocyte recruitment and regulating IFN-γ/IL-4 balance.

R. Guo, F. Xiao, Mao-xiang Zhu, 2014, Immunology letters.