S. Flohe

发表

GM-CSF counteracts hemorrhage-induced suppression of cytokine-producing capacity

B. Husain, S. Lendemans, M. Ackermann, 2003, Inflammation Research.

Effect of granulocyte-macrophage colony-stimulating factor on the immune response of circulating monocytes after severe trauma

S. Lendemans, F. Schade, S. Flohe, 2003, Critical care medicine.

Endotoxin tolerance in rats: influence on LPS-induced changes in excretory liver function

F. Siemers, F. Schade, S. Flohe, 2002, Inflammation Research.

Time course of various inflammatory mediators during recurrent endotoxemia.

P. Heinrich, C. Kirkpatrick, B. Klosterhalfen, 1992, Biochemical pharmacology.

Time course of IL-6 and TNFα release during endotoxin-induced endotoxin tolerance in rats

P. Heinrich, L. Flohé, A. Wendel, 1991 .

How to define severely injured patients? -- an Injury Severity Score (ISS) based approach alone is not sufficient.

R. Lefering, S. Flohe, T. Paffrath, 2014, Injury.

Facts and Fiction: The Impact of Hypothermia on Molecular Mechanisms following Major Challenge

M. van Griensven, S. Flohe, M. Frink, 2012, Mediators of inflammation.

Comparison of two different matrix-based autologous chondrocyte transplantation systems: 1 year follow-up results

M. Betsch, S. Flohe, K. Russe, 2011, European Journal of Trauma and Emergency Surgery.

The impact of arterial hypertension on polytrauma and traumatic brain injury.

R. Lefering, S. Flohe, J. Schneppendahl, 2012, Deutsches Arzteblatt international.

Haemostasis in shock Part 2: physiology of haemostasis

I. Cascorbi, W. Teske, S. Flohe, 2014 .

A Combined Trauma Model of Chest and Abdominal Trauma With Hemorrhagic Shock—Description of a New Porcine Model

S. Ruchholtz, M. van Griensven, S. Flohe, 2012, Shock.

Implant‐associated localized osteitis in murine femur fracture by biofilm forming Staphylococcus aureus: A novel experimental model

W. Meng, S. Flohe, C. MacKenzie, 2013, Journal of orthopaedic research : official publication of the Orthopaedic Research Society.

Interleukin-6, Its Hepatic Receptor and the Acute Phase Response of the Liver

P. Heinrich, S. Rose-John, S. Flohe, 1991 .

Kynurenine inhibits chondrocyte proliferation and is increased in synovial fluid of patients with septic arthritis

S. Flohe, J. Altrichter, M. Schädel-Höpfner, 2010, Journal of orthopaedic research : official publication of the Orthopaedic Research Society.

Interferon-γ counteracts reduced endotoxin responsiveness of whole blood following trauma and cardiopulmonary bypass

F. Schade, S. Flohe, J. Börgermann, 2000 .

Endotoxin tolerance in rats: expression of TNF-alpha, IL-6, IL-10, VCAM-1 AND HSP 70 in lung and liver during endotoxin shock.

M. Ackermann, F. Schade, S. Flohe, 1999, Cytokine.

Interleukin-10 is downregulated in mononuclear cells from endotoxin tolerant humans

F. Schade, S. Flohe, E. Kreuzfelder, 1997 .

Staurosporine resistance in inflammatory neutrophils is associated with the inhibition of caspase‐ and proteasome‐mediated Mcl‐1 degradation

S. Detmer, S. Wesselborg, S. Lehmann, 2016, Journal of leukocyte biology.

Depletion of neutrophil extracellular traps in vivo results in hypersusceptibility to polymicrobial sepsis in mice

S. Baldus, W. Meng, S. Flohe, 2012, Critical Care.

Deoxyribonuclease Is a Potential Counter Regulator of Aberrant Neutrophil Extracellular Traps Formation after Major Trauma

W. Meng, S. Flohe, M. Schädel-Höpfner, 2012, Mediators of inflammation.

Immunological reactions secondary to blood transfusion.

S. Flohe, D. Nast‐Kolb, P. Kobbe, 2007, Injury.

Level of Evidence Analysis for the Latest German National Guideline on Treatment of Patients with Severe and Multiple Injuries and ATLS

F. Walcher, S. Flohe, M. Münzberg, 2015, World Journal of Surgery.

Assessment of Patient-Reported Outcomes After Polytrauma: A Systematic Review

A. Herrmann-Frank, S. Flohe, M. Metzendorf, 2020 .

Immune response of severely injured patients – influence of surgical intervention and therapeutic impact

F. Schade, S. Flohe, C. Waydhas, 2007, Langenbeck's Archives of Surgery.

Th 1-Promoting Phenotype Maturation of Dendritic Cells Versus a Human Heat Shock Protein 60 Induces

S. Lendemans, S. Flohe, G. Meierhoff, 2003 .

Haemorrhagic shock in mice--intracellular signalling and immunomodulation of peritoneal macrophages' LPS response.

Meenakshi Rani, B. Husain, S. Lendemans, 2006, Immunobiology.

Dendritic Cell-Like Cells Accumulate in Regenerating Murine Skeletal Muscle after Injury and Boost Adaptive Immune Responses Only upon a Microbial Challenge

S. Flohe, B. Schumak, S. Flohé, 2016, PloS one.

Diversity of Interferon γ and Granulocyte-Macrophage Colony-Stimulating Factor in Restoring Immune Dysfunction of Dendritic Cells and Macrophages During Polymicrobial Sepsis

Hemant Agrawal, Meenakshi Rani, F. Schade, 2008, Molecular medicine.

Dendritic cells during polymicrobial sepsis rapidly mature but fail to initiate a protective Th1‐type immune response

Hemant Agrawal, F. Schade, S. Flohe, 2006, Journal of leukocyte biology.

Tumor necrosis factor-alpha production in whole blood after cardiopulmonary bypass: downregulation caused by circulating cytokine-inhibitory activities.

O. Kuss, F. Schade, S. Flohe, 2002, The Journal of thoracic and cardiovascular surgery.

GM-CSF priming of human monocytes is dependent on ERK1/2 activation

Meenakshi Rani, S. Lendemans, F. Schade, 2006, Journal of endotoxin research.

ORIGIN OF IMMUNOMODULATION AFTER SOFT TISSUE TRAUMA: POTENTIAL INVOLVEMENT OF EXTRACELLULAR HEAT-SHOCK PROTEINS

Hemant Agrawal, F. Schade, S. Flohe, 2007, Shock.

Limited volume resuscitation in hypotensive elderly multiple trauma is safe and prevents early clinical dilutive coagulopathy -- a matched-pair analysis from TraumaRegister DGU(®).

R. Lefering, S. Flohe, M. Leenen, 2014, Injury.

Expression and function of Toll‐like receptor 9 in severely injured patients prone to sepsis

S. Lendemans, S. Flohe, E. Kreuzfelder, 2006, Clinical and experimental immunology.

Antigen‐pulsed epidermal Langerhans cells protect susceptible mice from infection with the intracellular parasite Leishmania major

S. Flohe, H. Moll, S. Flohé, 1998, European journal of immunology.

MICROCIRCULATORY ALTERATIONS OF HEPATIC AND MESENTERIC MICROCIRCULATION IN ENDOTOXIN TOLERANCE

B. Husain, S. Lendemans, F. Schade, 2007, Shock.

Relation of ex vivo stimulated blood cytokine synthesis to post-traumatic sepsis.

F. Schade, S. Flohe, J. Börgermann, 1999, Cytokine.

Neue orale Antikoagulanzien

S. Flohe, T. Paffrath, A. Wafaisade, 2013, Der Unfallchirurg.

Analysis of intragraft cytokine expression during early reperfusion after liver transplantation using semi-quantitative RT-PCR.

F. Schade, S. Flohe, J. Börgermann, 1998, Cytokine.

Effects of endotoxin tolerance on liver function after hepatic ischemia/reperfusion injury in the rat

F. Siemers, F. Schade, S. Flohe, 2002, Critical care medicine.

Regulation of cytokine synthesis in cardiac surgery: Role of extracorporeal circuit and humoral mediators in vivo and in vitro

O. Kuss, F. Schade, S. Flohe, 2007, Inflammation Research.

[Fractures of the shaft of the femur].

S. Flohe, T. Lögters, J. Windolf, 2009, Der Unfallchirurg.

Level 3 guideline on the treatment of patients with severe/multiple injuries

Monika Becker, D. Pieper, M. Eikermann, 2018, European Journal of Trauma and Emergency Surgery.

[Platelet-rich plasma combined with autologous cancellous bone : An alternative therapy for persistent non-union?].

M. Betsch, S. Flohe, W. Linhart, 2011, Der Unfallchirurg.

Damage Control Orthopedics

S. Flohe, A. Franke, D. Bieler, 2018, Current Trauma Reports.

Reconstruction of septic diaphyseal bone defects with the induced membrane technique.

S. Flohe, S. Gehrmann, R. Kaufmann, 2015, Injury.

[Preclinical and intrahospital management of mass casualties and terrorist incidents].

S. Flohe, E. Kollig, B. Friemert, 2017, Der Chirurg; Zeitschrift fur alle Gebiete der operativen Medizen.

Lysostaphin-Coated Titan-Implants Preventing Localized Osteitis by Staphylococcus aureus in a Mouse Model

S. Flohe, T. Lögters, J. Windolf, 2014, PloS one.

Invited review: Deterioration of the immune system after trauma: signals and cellular mechanisms

F. Schade, S. Flohe, S. Flohé, 2008, Innate immunity.

Adipocyte-secreted factors increase osteoblast proliferation and the OPG/RANKL ratio to influence osteoclast formation

W. Scherbaum, S. Flohe, S. Schinner, 2012, Molecular and Cellular Endocrinology.

Induced Hypothermia Does Not Harm Hemodynamics after Polytrauma: A Porcine Model

S. Ruchholtz, M. van Griensven, S. Flohe, 2015, Mediators of inflammation.

Isolated closed minor-muscle injury of the lower leg did not cause an obvious systemic immune response

B. Husain, S. Lendemans, F. Schade, 2010, Inflammation Research.

Molecular Mechanisms Underlying Delayed Apoptosis in Neutrophils from Multiple Trauma Patients with and without Sepsis

S. Flohe, T. Lögters, J. Windolf, 2012, Molecular medicine.

Stabilization of chronic proximal tibiofibular joint instability with a semitendinosus graft.

S. Flohe, K. Russe, P. Kobbe, 2010, Acta orthopaedica Belgica.

[Fractures of the patella].

S. Flohe, M. Wild, J. Windolf, 2010, Der Unfallchirurg.

Nonoperative Management of Tracheobronchial Injuries in Severely Injured Patients

H. Kuehl, G. Stavrou, S. Flohe, 2005, Surgery Today.

Increased serum soluble Fas after major trauma is associated with delayed neutrophil apoptosis and development of sepsis

S. Flohe, T. Lögters, J. Windolf, 2011, Critical care.

Induced hypothermia reduces the hepatic inflammatory response in a swine multiple trauma model

S. Ruchholtz, M. van Griensven, S. Flohe, 2014, The journal of trauma and acute care surgery.

Toll-like receptor 2 and 4 expression after severe injury is not involved in the dysregulation of the innate immune system.

Meenakshi Rani, S. Lendemans, F. Schade, 2007, The Journal of trauma.

Human Heat Shock Protein 60 Induces Maturation of Dendritic Cells Versus a Th1-Promoting Phenotype1

H. Kolb, S. Lendemans, S. Flohe, 2003, The Journal of Immunology.

Influence of surgical intervention in the immune response of severely injured patients

S. Lendemans, F. Schade, S. Flohe, 2004, Intensive Care Medicine.

Circulating growth/differentiation factor 15 is associated with human CD56bright natural killer cell dysfunction and nosocomial infection in severe systemic inflammation

R. Halbgebauer, M. Huber-Lang, S. Flohe, 2019, EBioMedicine.

Differential immunostimulating effect of Granulocyte-macrophage colony-stimulating factor (GM-CSF), Granulocyte colony-stimulating factor (G-CSF) and Interferon γ (IFNγ) after severe trauma

S. Lendemans, F. Schade, S. Flohe, 2007, Inflammation Research.

Surgical Management of Proximal Interphalangeal Joint Repetitive Stress Epiphyseal Fracture Nonunion in Elite Sport Climbers.

S. Flohe, C. Lutter, I. Schoeffl, 2017, The Journal of hand surgery.

Stimulation of Fas signaling down-regulates activity of neutrophils from major trauma patients with SIRS.

J. Cinatl, S. Flohe, J. Altrichter, 2011, Immunobiology.

Influence of granulocyte-macrophage colony-stimulating factor (GM-CSF) on whole blood endotoxin responsiveness following trauma, cardiopulmonary bypass, and severe sepsis.

F. Schade, S. Flohe, E. Kreuzfelder, 1999, Shock.

Cytokine synthesis in the liver of endotoxin-tolerant and normal rats during hemorrhagic shock

H. Redl, S. Bahrami, F. Schade, 2001, Journal of endotoxin research.

Endotoxin tolerance protects against local hepatic ischemia/reperfusion injury in the rat

F. Siemers, M. Ackermann, F. Schade, 2000, Journal of endotoxin research.

Time course of IL-6 and TNF alpha release during endotoxin-induced endotoxin tolerance in rats.

P. Heinrich, L. Flohé, A. Wendel, 1991, Biochemical pharmacology.

[Clinical course and prognostic significance of immunological and functional parameters after severe trauma].

S. Lendemans, S. Flohe, C. Waydhas, 2004, Der Unfallchirurg.

[Significance of liver trauma for the incidence of sepsis, multiple organ failure and lethality of severely injured patients. An organ-specific evaluation of 24,771 patients from the trauma register of the DGU].

R. Lefering, S. Ruchholtz, S. Lendemans, 2008, Der Unfallchirurg.

Relation of a TNF gene polymorphism to severe sepsis in trauma patients.

F. Stüber, F. Schade, S. Flohe, 1999, Annals of surgery.

Relevance of induced and accidental hypothermia after trauma-haemorrhage–what do we know from experimental models in pigs?

P. Radermacher, M. Huber-Lang, S. Ruchholtz, 2014, Intensive Care Medicine Experimental.

Induced hypothermia does not impair coagulation system in a swine multiple trauma model

S. Ruchholtz, M. van Griensven, S. Flohe, 2013, The journal of trauma and acute care surgery.

Wesentliche Maßnahmen zur prähospitalen Versorgung schwerverletzter Patienten

U. Schweigkofler, S. Flohe, T. Paffrath, 2015, Der Unfallchirurg.

Induced Hypothermia Preserves the Functional Enterocyte Mass in A Porcine Multiple Trauma Model: Retracted.

M. van Griensven, S. Flohe, F. Hildebrand, 2016, Shock.

Acute management and outcome of multiple trauma patients with pelvic disruptions

S. Flohe, B. Bouillon, M. Maegele, 2012, Critical Care.

Assessment of patient-reported outcomes after polytrauma: protocol for a systematic review

J. Sturm, A. Herrmann-Frank, S. Flohe, 2018, BMJ Open.

Trauma quality indicators: internationally approved core factors for trauma management quality evaluation

A. Peitzman, Ionut Negoi, A. Buia, 2021, World Journal of Emergency Surgery.

Expression of HSP 70 as a potential prognostic marker for acute rejection in human liver transplantation

F. Schade, S. Flohe, R. Lange, 1998, Transplant international : official journal of the European Society for Organ Transplantation.

HLA-DR monitoring in the intensive care unit--more than a tool for the scientist in the laboratory?

S. Flohe, M. Scholz, 2009, Critical care medicine.

Sublethal hemorrhagic shock reduces tumor necrosis factor-alpha-producing capacity in different cell compartments.

M. Ackermann, F. Schade, S. Flohe, 2000, European cytokine network.

[Interhospital transfer of severely injured patients in Germany. Evaluation of the DGU trauma register].

R. Lefering, S. Flohe, T. Lögters, 2012, Der Unfallchirurg.

[Definition of polytrauma in the German DRG system 2006. Up to 30% "incorrect classifications"].

R. Lefering, S. Ruchholtz, S. Flohe, 2007, Der Unfallchirurg.

Coagulation management of bleeding trauma patients is changing in German trauma centers: An analysis from the trauma registry of the German Society for Trauma Surgery

C. Probst, R. Lefering, S. Lendemans, 2012, The journal of trauma and acute care surgery.

[Recommendations for Releasing the Pelvic Binder After a Non-Invasive Pelvic Stabilisation Procedure Under Emergency Room Conditions].

R. Hoffmann, U. Schweigkofler, S. Flohe, 2016, Zeitschrift fur Orthopadie und Unfallchirurgie.

Development of trauma systems in Europe—reports from England, Germany, the Netherlands, and Spain

C. Moran, K. Willett, I. Schipper, 2019, OTA international : the open access journal of orthopaedic trauma.

Endotoxin Tolerance

F. Schade, S. Flohe, E. Kreuzfelder, 2020, Endotoxin in Health and Disease.

[Surgical management of life-threatening injuries].

S. Flohe, D. Nast‐Kolb, 2009, Der Unfallchirurg.

[Interruption of the diagnostic algorithm and immediate surgical intervention after major trauma--incidence and clinical relevance. Analysis of the Trauma Register of the German Society for Trauma Surgery].

R. Lefering, S. Flohe, I. Alldinger, 2010, Der Unfallchirurg.

Interferon-gamma counteracts reduced endotoxin responsiveness of whole blood following trauma and cardiopulmonary bypass.

F. Schade, S. Flohe, J. Börgermann, 2000, Journal of endotoxin research.

Granulocyte-macrophage colony-stimulating factor (GM-CSF) restores decreased monocyte HLA-DR expression after cardiopulmonary bypass.

R. Silber, S. Lendemans, S. Flohe, 2007, The Thoracic and cardiovascular surgeon.

Induced hypothermia does not impair coagulation system in a swine multiple trauma model

S. Ruchholtz, M. van Griensven, S. Flohe, 2013, The journal of trauma and acute care surgery.

[Current practice in coagulation and transfusion therapy in multiple trauma patients: A German nation-wide online survey].

C. Probst, T. Tjardes, S. Flohe, 2015, Der Unfallchirurg.

The impact of arterial hypertension on polytrauma and traumatic brain injury.

R. Lefering, S. Flohe, J. Schneppendahl, 2012, Deutsches Arzteblatt international.