D. Heumann

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The Generation of Inflammatory Responses

T. Calandra, M. Glauser, D. Heumann, 2002 .

Augmentation of the Lipopolysaccharide-Neutralizing Activities of Human Cathelicidin CAP18/LL-37-Derived Antimicrobial Peptides by Replacement with Hydrophobic and Cationic Amino Acid Residues

I. Nagaoka, D. Heumann, S. Hirota, 2002, Clinical and Vaccine Immunology.

Cathelicidin Family of Antibacterial Peptides CAP18 and CAP11 Inhibit the Expression of TNF-α by Blocking the Binding of LPS to CD14+ Cells1

I. Nagaoka, D. Heumann, S. Hirota, 2001, The Journal of Immunology.

Cathelicidin Family of Antibacterial Peptides

I. Nagaoka, D. Heumann, S. Hirota, 2001 .

Anticytokine strategies for the treatment of septic shock: relevance of animal models.

M. Glauser, D. Heumann, 1996, Current topics in microbiology and immunology.

Contribution of TNF and of LPS in endotoxemic shock in mice. A reappraisal

M. Glauser, D. Heumann, D. Le Roy, 1996 .

Interferon gamma receptor deficient mice are resistant to endotoxic shock

B. Ryffel, S. Huang, M. Aguet, 1994, The Journal of experimental medicine.

Association between protective efficacy of anti-lipopolysaccharide (LPS) antibodies and suppression of LPS-induced tumor necrosis factor alpha and interleukin 6. Comparison of O side chain-specific antibodies with core LPS antibodies

G. Grau, M. Glauser, D. Heumann, 1990, The Journal of experimental medicine.

Postnatal development of the mouse cerebral neocortex. II. Quantitative cytoarchitectonics of visual and auditory areas.

G. Leuba, D. Heumann, T. Rabinowicz, 1977, Journal fur Hirnforschung.

Protection from septic shock by neutralization of macrophage migration inhibitory factor

R. Bucala, T. Calandra, B. Echtenacher, 2000, Nature Medicine.

The dual role of LBP and CD14 in response to Gram-negative bacteria or Gram-negative compounds

D. Heumann, R. Lauener, B. Ryffel, 2003, Journal of endotoxin research.

Role of Plasma, Lipopolysaccharide-Binding Protein, and CD14 in Response of Mouse Peritoneal Exudate Macrophages to Endotoxin

T. Calandra, M. Glauser, D. Heumann, 2001, Infection and Immunity.

against Gram-Negative Bacteria Protein and CD14 in Immune Responses Critical Role of Lipopolysaccharide-Binding

T. Calandra, F. Padova, M. Glauser, 2001 .

CD14 and LBP in endotoxemia and infections caused by Gram-negative bacteria

D. Heumann, 2001, Journal of endotoxin research.

Gram-Negative Bacteria Protein and CD 14 in Immune Responses Critical Role of Lipopolysaccharide-Binding

T. Calandra, F. Padova, M. Glauser, 2001 .

CD14 and LBP in endotoxemia and infections caused by Gram-negative bacteria.

D. Heumann, 2001 .

Critical Role of Lipopolysaccharide-Binding Protein and CD14 in Immune Responses against Gram-Negative Bacteria1

T. Calandra, F. D. Di Padova, M. Glauser, 2001, The Journal of Immunology.

Molecular basis of host-pathogen interaction in septic shock.

T. Calandra, M. Glauser, D. Heumann, 1998, Current opinion in microbiology.

Gram-Negative Bacteria Protein and CD 14 in Immune Responses Critical Role of Lipopolysaccharide-Binding

T. Calandra, F. Padova, M. Glauser, 2001 .

Cytokine production after intravenous or peritoneal gram-negative bacterial challenge in mice. Comparative protective efficacy of antibodies to tumor necrosis factor-alpha and to lipopolysaccharide.

P. Abbet, M. Glauser, D. Heumann, 1992, Journal of immunology.

Control of lipopolysaccharide (LPS) binding and LPS-induced tumor necrosis factor secretion in human peripheral blood monocytes.

R. Ulevitch, M. Glauser, D. Heumann, 1992, Journal of immunology.

Lipopolysaccharide-binding protein as a major plasma protein responsible for endotoxemic shock.

M. Glauser, D. Heumann, D. Le Roy, 1993, Proceedings of the National Academy of Sciences of the United States of America.

Mode of action of anti-lipopolysaccharide-binding protein antibodies for prevention of endotoxemic shock in mice.

M. Glauser, D. Heumann, D. Le Roy, 1994, Proceedings of the National Academy of Sciences of the United States of America.

Reactivity of murine and human recombinant LPS-binding protein (LBP) within LPS and gram negative bacteria.

C. Jongeneel, R. Ulevitch, V. Kravchenko, 1995, Journal of inflammation.

LBP or the Presentation of LPS / LBP by Blocking Either the Binding of LPS to ( LBP ) Protect Mice from Lethal Endotoxemia Lipopolysaccharide ( LPS )-Binding Protein Monoclonal Antibodies to Murine

R. Landmann, T. Calandra, F. Padova, 1999 .

Regulation of fetal hemoglobin expression during hematopoietic stem cell development and its importance in bone metabolism and osteoporosis

A. Ulmer, E. Rietschel, D. Heumann, 2018, International immunopharmacology.

Postnatal development of the mouse cerebral neocortex. I. Quantitative cytoarchitectonics of some motor and sensory areas.

G. Leuba, D. Heumann, T. Rabinowicz, 1977, Journal fur Hirnforschung.

Production of the acute-phase protein lipopolysaccharide-binding protein by respiratory type II epithelial cells: implications for local defense to bacterial endotoxins.

E. Wouters, W. Buurman, D. Heumann, 2000, American journal of respiratory cell and molecular biology.

Hyperlipoproteinemic low-density lipoprotein receptor-deficient mice are more susceptible to sepsis than corresponding wild-type mice

D. Heumann, A. Minchenko, J. Flynn, 2003, Journal of endotoxin research.

Genomic organization and chromosomal localization of the mouse lipopolysaccharide binding protein gene

C. Jongeneel, D. Heumann, S. Lengacher, 1999, Immunogenetics.

Activation of resting T lymphocytes by cross‐linked anti‐CD3 (T3)

T. Vischer, D. Heumann, 1987, European journal of immunology.

Purification of lipopolysaccharide binding protein.

D. Heumann, 2000, Methods in molecular medicine.

Gram-positive cell walls stimulate synthesis of tumor necrosis factor alpha and interleukin-6 by human monocytes

A. Tomasz, M. Glauser, D. Heumann, 1994, Infection and immunity.

Lipopolysaccharide (LPS)-binding protein in human serum determines the tumor necrosis factor response of monocytes to LPS.

T. Calandra, M. Glauser, D. Heumann, 1994, The Journal of infectious diseases.

CD14 expression on monocytes and TNF alpha production in patients with septic shock, cardiogenic shock or bacterial pneumonia.

M. Schaller, R. Chioléro, T. Calandra, 2001, Swiss medical weekly.

Monoclonal antibodies to murine lipopolysaccharide (LPS)-binding protein (LBP) protect mice from lethal endotoxemia by blocking either the binding of LPS to LBP or the presentation of LPS/LBP complexes to CD14.

R. Landmann, T. Calandra, F. D. Di Padova, 1999, Journal of immunology.

The Role of Lipopolysaccharide Binding Protein in Resistance to Salmonella Infections in Mice1

D. Golenbock, J. Fierer, D. Heumann, 2002, The Journal of Immunology.

in Mice Infections Salmonella Protein in Resistance to The Role of Lipopolysaccharide Binding

D. Golenbock, J. Fierer, D. Heumann, 2002 .

LPS binding protein (LBP) function in germfree mice

M. Glauser, D. Heumann, D. Le Roy, 1997 .

Shock: An Update

M. Glauser, D. Heumann, D. Baumgartner, 2010 .

Cytokines in septic shock.

T. Calandra, P. Bochud, D. Heumann, 2002, Current clinical topics in infectious diseases.

Characterisation of bovine lipopolysaccharide binding protein and the in vivo acute phase response to Pasteurella haemolytica Type A.

D. Heumann, P. Gallay, P. Eckersall, 1995, Veterinary immunology and immunopathology.

Immunomodulation by α2‐macroglobulin and α2‐macroglobulin‐proteinase complexes: the effect on the human T lymphocyte response

T. Vischer, D. Heumann, Thomas L. Vischer, 1988 .

Human large granular lymphocytes contain an esterase activity usually considered as specific for the myeloid series

D. Heumann, M. Colombatti, J. Mach, 1983, European journal of immunology.

Do monoclonal antibodies and anticytokines still have a future in infectious diseases?

M. Glauser, D. Heumann, J. Cohen, 1995, The American journal of medicine.

Short time exposure to lipopolysaccharide is sufficient to activate human monocytes.

C. Jongeneel, M. Glauser, D. Heumann, 1993, Journal of immunology.

Radioimmunoassay versus flow cytometric assay to quantify LPS-binding protein (LBP) concentrations in human plasma.

R. Landmann, M. Glauser, D. Heumann, 1994, Journal of immunological methods.

Bactericidal/permeability-increasing protein inhibits induction of macrophage nitric oxide production by lipopolysaccharide.

M. Glauser, D. Heumann, P. Gallay, 1994, The Journal of infectious diseases.

Competition between bactericidal/permeability-increasing protein and lipopolysaccharide-binding protein for lipopolysaccharide binding to monocytes.

M. Glauser, D. Heumann, P. Gallay, 1993, The Journal of infectious diseases.

Purification and characterization of murine lipopolysaccharide-binding protein

R. Ulevitch, M. Glauser, D. Heumann, 1993, Infection and immunity.

Characterization of a monoclonal antibody (A12) that defines a human acute lymphoblastic leukemia-associated differentiation antigen.

R. Sékaly, D. Heumann, F. Buchegger, 1983, Hybridoma.

Teichoic Acids Are Not Required for Streptococcus pneumoniae and Staphylococcus aureus Cell Walls To Trigger the Release of Tumor Necrosis Factor by Peripheral Blood Monocytes

D. Heumann, P. Majcherczyk, P. Moreillon, 2003, Infection and Immunity.

Production of tumor necrosis factor-α by naive or memory T lymphocytes activated via CD28

S. Miescher, D. Heumann, J. Gérain, 1992 .

Streptococcus mitis cell walls and lipopolysaccharide induce lethality in D-galactosamine-sensitized mice by a tumor necrosis factor-dependent pathway

G. Grau, M. Glauser, D. Heumann, 1996, Infection and immunity.

Contribution of TNF/TNF receptor and of Fas ligand to toxicity in murine models of endotoxemia and bacterial peritonitis.

J. Tschopp, B. Ryffel, M. Hahne, 1995, Journal of inflammation.

Antibodies to lipopolysaccharides after immunization of humans with the rough mutant Escherichia coli J5.

T. Calandra, M. Glauser, D. Heumann, 1991, The Journal of infectious diseases.

Pathogenesis and potential strategies for prevention and treatment of septic shock: an update.

Jonathan Cohen, M. Glauser, D. Heumann, 1994, Clinical infectious diseases : an official publication of the Infectious Diseases Society of America.

High circulating levels of interleukin-6 in patients with septic shock: evolution during sepsis, prognostic value, and interplay with other cytokines. The Swiss-Dutch J5 Immunoglobulin Study Group.

T. Calandra, M. Glauser, D. Heumann, 1991, The American journal of medicine.

Initial responses to endotoxins and Gram-negative bacteria.

T. Roger, D. Heumann, 2002, Clinica chimica acta; international journal of clinical chemistry.

Expression of common acute lymphoblastic leukemia antigen (CALLA) on human malignant melanoma cell lines.

D. Heumann, C. Girardet, J. Mach, 1983, Journal of immunology.

Rapid Publication Detection of the Common Acute Lymphoblastic Leukemia Antigen in the Serum of Leukemia Patients

G. Losa, D. Heumann, F. Buchegger, 2013 .

Antibodies to core lipopolysaccharide determinants: absence of cross-reactivity with heterologous lipopolysaccharides.

M. Glauser, D. Heumann, J. Baumgartner, 1991, The Journal of infectious diseases.

Cytokines, nitrite/nitrate, soluble tumor necrosis factor receptors, and procalcitonin concentrations: comparisons in patients with septic shock, cardiogenic shock, and bacterial pneumonia.

R. Chioléro, B. Yersin, C. Jaccard, 1997, Critical care medicine.

Evolution of plasminogen activator inhibitor type 1 in patients with septic shock — correlation with cytokine concentrations

T. Calandra, M. Glauser, D. Heumann, 1993 .

Molecular interactions of Leishmania promastigote surface protease with human α2-macroglobulin

T. Vischer, D. Heumann, D. Burger, 1989 .

Expression of MHC class II molecules contributes to lipopolysaccharide responsiveness

D. Heumann, C. Siegrist, R. Lauener, 2000, European journal of immunology.

Digestion of Streptococcus pneumoniae Cell Walls with Its Major Peptidoglycan Hydrolase Releases Branched Stem Peptides Carrying Proinflammatory Activity*

H. Langen, M. Fountoulakis, M. Glauser, 1999, The Journal of Biological Chemistry.

Distribution and properties of Fc receptors for IgG on different leucocyte populations in man.

D. Heumann, L. Moretta, M. Colombatti, 1981, Clinical and experimental immunology.

Characterization of acute undifferentiated leukemia by combined analysis of plasma membrane-associated gamma-glutamyltranspeptidase and soluble terminal transferase.

G. Losa, D. Heumann, V. V. von Fliedner, 1985, Blood.

Identification by a monoclonal antibody of a glycolipid highly expressed by cells from the human myeloid lineage

D. Heumann, C. Girardet, J. Mach, 1983, International journal of cancer.

Postnatal development of the mouse cerebral neocortex. IV. Evolution of the total cortical volume, of the population of neurons and glial cells.

G. Leuba, D. Heumann, T. Rabinowicz, 1978, Journal fur Hirnforschung.

IFN-gamma involvement in the severity of gram-negative infections in mice.

D. Leroy, M. Glauser, D. Heumann, 1993, Journal of immunology.

NITRIC OXIDE PRODUCTION IN EXPERIMENTAL GRAM-NEGATIVE INFECTION: STUDIES WITH CYTOKINE RECEPTOR-DEFICIENT MICE

M. Glauser, D. Heumann, D. Le Roy, 1998, Shock.

Analysis of cytokine immune response profile in response to inflammatory stimuli in mice with genetic defects in fetal and adult hemoglobin chain expression

A. Terskikh, A. Ulmer, E. Rietschel, 2018, The Pharmacogenomics Journal.

Human α2-macroglobulin as an inhibitor of insoluble trypsin

T. Vischer, D. Heumann, D. Burger, 1989 .

Postnatal development of the visual cortex of the mouse after enucleation at birth

D. Heumann, T. Rabinowicz, T. Rabinowicz, 2004, Experimental Brain Research.

Postnatal development of the dorsal lateral geniculate nucleus in the normal and enucleated albino mouse

D. Heumann, T. Rabinowicz, 2004, Experimental Brain Research.

Monoclonal antibody against a "Pan-T-cell" antigen expressed by thymocytes, peripheral T-lymphocytes and T-cell leukemias.

R. Sékaly, D. Heumann, C. Girardet, 1984, Molecular immunology.

F. D. Di Padova, E. Rietschel, M. Glauser, 1997, Infection and immunity.

NEURONAL DEATH IN THE DEVELOPMENT AND AGING OF THE CEREBRAL CORTEX OF THE MOUSE

G. Leuba, D. Heumann, 1981, Neuropathology and applied neurobiology.

Enhancement of murine macrophage binding of and response to bacterial lipopolysaccharide (LPS) by LPS‐binding protein

R. Ulevitch, D. Heumann, P. Gallay, 1992, Journal of leukocyte biology.

Determination of ectoenzyme activities in leukemic cells and in established hematopoietic cell lines

G. Losa, D. Heumann, V. V. von Fliedner, 1986, American journal of hematology.

Expression and Characterization of Leucocyte Antigens

P. Gregersen, K. Lennert, B. Dörken, 1984 .

Monocyte deactivation in septic shock.

T. Calandra, M. Glauser, D. Heumann, 1998, Current opinion in infectious diseases.

Lipopolysaccharide binding protein as a marker of inflammation in synovial fluid of patients with arthritis: correlation with interleukin 6 and C-reactive protein.

T. Vischer, M. Glauser, D. Heumann, 1995, The Journal of rheumatology.

CD14 is a pattern recognition receptor.

A. Tomasz, R. Ulevitch, V. Kravchenko, 1994, Immunity.

Lipopolysaccharide binding protein (LBP) as a marker of protein leakage in cerebrospinal fluid

H. Albrecht, M. Glauser, D. Heumann, 1995 .

Therapeutic Approaches Targeting Endotoxin-Derived Mediators

M. Glauser, D. Heumann, J. Baumgartner, 2020 .

Analysis of cytokine immune response profile in response to inflammatory stimuli in mice with genetic defects in fetal and adult hemoglobin chain expression

A. Terskikh, A. Ulmer, E. Rietschel, 2018, The Pharmacogenomics Journal.

Morphologic Maturation of the Brain: A Quantitative Study

G. Leuba, D. Heumann, T. Rabinowicz, 1977 .