L. Ao

发表

TNF-α and myocardial depression in endotoxemic rats: temporal discordance of an obligatory relationship.

A. Harken, D. Meldrum, Xianzhong Meng, 1998, American journal of physiology. Regulatory, integrative and comparative physiology.

Abstract 165: Microrna-486 Regulates Fibroblast-to-myofibroblast Transition in Human Aortic Valve Interstitial Cells

Xianzhong Meng, L. Ao, D. Fullerton, 2015, Arteriosclerosis, Thrombosis, and Vascular Biology.

Mechanisms of immature myocardial tolerance to ischemia: phenotypic differences in antioxidants, stress proteins, and oxidases.

A. Harken, L. Ao, R. T. Rowland, 1995, Surgery.

Multiple mitogen-activated protein kinases are regulated by hyperosmolality in mouse IMCD cells.

T. Berl, L. Heasley, L. Ao, 1997, The American journal of physiology.

The intestinal microbiota associated with cardiac valve calcification differs from that of coronary artery disease.

Xianzhong Meng, L. Ao, Hai-yue Liu, 2019, Atherosclerosis.

TLR4 Stimulation Promotes Human AVIC Fibrogenic Activity through Upregulation of Neurotrophin 3 Production

Xianzhong Meng, L. Ao, D. Fullerton, 2020, International journal of molecular sciences.

Pro-osteogenic phenotype of human aortic valve interstitial cells is associated with higher levels of Toll-like receptors 2 and 4 and enhanced expression of bone morphogenetic protein 2.

J. Cleveland, Xiaoping Yang, Xianzhong Meng, 2009, Journal of the American College of Cardiology.

Klotho suppresses high phosphate-induced osteogenic responses in human aortic valve interstitial cells through inhibition of Sox9

J. Cleveland, Xianzhong Meng, L. Ao, 2017, Journal of Molecular Medicine.

Inhibition of cyclic-3',5'-nucleotide phosphodiesterase abrogates the synergism of hypoxia with lipopolysaccharide in the induction of macrophage TNF-alpha production.

A. Harken, L. Ao, B. Shames, 2001, The Journal of surgical research.

Biglycan Induces the Expression of Osteogenic Factors in Human Aortic Valve Interstitial Cells via Toll-Like Receptor-2

J. Cleveland, Xianzhong Meng, L. Ao, 2012, Arteriosclerosis, thrombosis, and vascular biology.

Inhibition of Myocardial TNF‐α Production by Heat Shock: A Potential Mechanism of Stress‐Induced Cardioprotection against Postischemic Dysfunction a

A. Harken, D. Meldrum, Xianzhong Meng, 1999, Annals of the New York Academy of Sciences.

Toll-like Receptor 4 Mediates the Inflammatory Responses and Matrix Protein Remodeling in Remote Non-Ischemic Myocardium in a Mouse Model of Myocardial Ischemia and Reperfusion

J. Cleveland, Xianzhong Meng, L. Ao, 2015, PloS one.

Elevated Expression of TLR2 in Aging Hearts Exacerbates Cardiac Inflammatory Response and Adverse Remodeling Following Ischemia and Reperfusion Injury

Xianzhong Meng, L. Ao, D. Fullerton, 2022, Frontiers in Immunology.

Klotho suppresses the inflammatory responses and ameliorates cardiac dysfunction in aging endotoxemic mice

J. Cleveland, Xianzhong Meng, L. Ao, 2017, Oncotarget.

Over-expression of neurotrophin 3 in human aortic valves affected by calcific disease induces the osteogenic responses via the Trk-Akt pathway.

J. Cleveland, Xianzhong Meng, L. Ao, 2015, Biochimica et biophysica acta.

Human Myocardial Tissue TNFαExpression Following Acute Global IschemiaIn Vivo

A. Harken, D. Meldrum, C. Dinarello, 1998 .

Gender disparity in the role of TLR2 in post-ischemic myocardial inflammation and injury.

J. Cleveland, Xianzhong Meng, L. Ao, 2015, International journal of clinical and experimental medicine.

Myocardial TLR4 is a determinant of neutrophil infiltration after global myocardial ischemia: mediating KC and MCP-1 expression induced by extracellular HSC70.

J. Cleveland, Xianzhong Meng, L. Ao, 2009, American journal of physiology. Heart and circulatory physiology.

Cross-Talk Between the Toll-Like Receptor 4 and Notch1 Pathways Augments the Inflammatory Response in the Interstitial Cells of Stenotic Human Aortic Valves

J. Cleveland, Xianzhong Meng, L. Ao, 2012, Circulation.

Signaling for myocardial depression in hemorrhagic shock: roles of Toll-like receptor 4 and p55 TNF-α receptor

A. Harken, Xianzhong Meng, L. Ao, 2005 .

LPS induces late cardiac functional protection against ischemia independent of cardiac and circulating TNF-α.

A. Harken, D. Meldrum, Xianzhong Meng, 1997, American journal of physiology. Heart and circulatory physiology.

ICAM-1 and VCAM-1 mediate endotoxemic myocardial dysfunction independent of neutrophil accumulation.

A. Harken, Xianzhong Meng, L. Ao, 2002, American journal of physiology. Regulatory, integrative and comparative physiology.

The interaction between myocardial depressant factors in endotoxemic cardiac dysfunction: role of TNF-alpha in TLR4-mediated ICAM-1 expression.

C. Dinarello, Xianzhong Meng, L. Ao, 2007, Cytokine.

Reduction of infarct size in the rat heart by LPS preconditioning is associated with expression of angiogenic growth factors and increased capillary density.

A. Harken, L. Ao, B. Shames, 1999, Shock.

Presence of the M-type sPLA(2) receptor on neutrophils and its role in elastase release and adhesion.

E. Moore, C. Silliman, G. Zallen, 2002, American journal of physiology. Cell physiology.

Myocardial gene reprogramming associated with a cardiac cross-resistant state induced by LPS preconditioning.

A. Harken, S. Nordeen, Xianzhong Meng, 1998, American journal of physiology. Cell physiology.

Augmented Osteogenic Responses in Human Aortic Valve Cells Exposed to oxLDL and TLR4 Agonist: A Mechanistic Role of Notch1 and NF-κB Interaction

Xianzhong Meng, L. Ao, D. Fullerton, 2014, PloS one.

Expression of functional Toll-like receptors 2 and 4 in human aortic valve interstitial cells: potential roles in aortic valve inflammation and stenosis.

J. Cleveland, M. Weyant, Xiaoping Yang, 2008, American journal of physiology. Cell physiology.

TLR4 mediates LPS-induced HO-1 expression in mouse liver: Role of TNF-α and IL-1β

A. Harken, Xianzhong Meng, L. Ao, 2003 .

Endotoxin induces cardiac HSP70 and resistance to endotoxemic myocardial depression in rats.

W. Franklin, A. Harken, S. Nordeen, 1996, The American journal of physiology.

Hemoglobin-based oxygen carrier induces hepatic heme oxygenase 1 expression in Kupffer cells.

M. Weyant, E. Moore, Xianzhong Meng, 2007, Surgery.

Enhanced monocyte chemoattractant protein-1 production in aging mice exaggerates cardiac depression during endotoxemia

Xianzhong Meng, L. Ao, D. Fullerton, 2014, Critical Care.

MicroRNA-204 Deficiency in Human Aortic Valves Elevates Valvular Osteogenic Activity

Xianzhong Meng, L. Ao, D. Fullerton, 2019, International journal of molecular sciences.

Notch1 Promotes the Pro-Osteogenic Response of Human Aortic Valve Interstitial Cells via Modulation of ERK1/2 and Nuclear Factor-&kgr;B Activation

M. Weyant, Xianzhong Meng, L. Ao, 2013, Arteriosclerosis, thrombosis, and vascular biology.

Oxidized Low Density Lipoprotein Induces Bone Morphogenetic Protein-2 in Coronary Artery Endothelial Cells via Toll-like Receptors 2 and 4*

Xianzhong Meng, L. Ao, D. Fullerton, 2011, The Journal of Biological Chemistry.

LPS induces late cardiac functional protection against ischemia independent of cardiac and circulating TNF-alpha.

D. Meldrum, L. Ao, B. Cain, 1997, The American journal of physiology.

TNF-α-dependent bilateral renal injury is induced by unilateral renal ischemia-reperfusion

A. Harken, K. Meldrum, D. Meldrum, 2002 .

Differential cellular immunolocalization of renal tumour necrosis factor‐α production during ischaemia versus endotoxaemia

A. Harken, D. Meldrum, A. Ayala, 2001, Immunology.

Extracellular heat shock cognate protein 70 induces cardiac functional tolerance to endotoxin: differential effect on TNF-alpha and ICAM-1 levels in heart tissue.

Xianzhong Meng, L. Ao, D. Fullerton, 2010, Cytokine.

Attenuated Recovery of Contractile Function in Aging Hearts Following Global Ischemia/Reperfusion: Role of Extracellular HSP27 and TLR4

J. Cleveland, Xianzhong Meng, L. Ao, 2016, Molecular Medicine.

Norepinephrine induces cardiac heat shock protein 70 and delayed cardioprotection in the rat through alpha 1 adrenoceptors.

A. Harken, Xianzhong Meng, L. Ao, 1996, Cardiovascular research.

Expression of GTPase-deficient Ras inhibits vasopressin signaling in cultured cortical collecting duct cells.

T. Berl, L. Heasley, L. Ao, 1995, The Journal of clinical investigation.

Polymerized hemoglobin induces heme oxygenase-1 protein expression and inhibits intercellular adhesion molecule-1 protein expression in human lung microvascular endothelial cells.

E. Moore, M. Walsh, L. Ao, 2005, Journal of the American College of Surgeons.

Microfilaments facilitate TLR4-mediated ICAM-1 expression in human aortic valve interstitial cells.

J. Cleveland, Xiaoping Yang, Xianzhong Meng, 2011, The Journal of surgical research.

Toll-Like Receptor-4 Is a Mediator of Proliferation in Esophageal Adenocarcinoma.

M. Weyant, Xianzhong Meng, L. Ao, 2019, The Annals of thoracic surgery.

Human myocardial tissue TNFalpha expression following acute global ischemia in vivo.

A. Harken, D. Meldrum, C. Dinarello, 1998, Journal of molecular and cellular cardiology.

Cytokines link Toll-like receptor 4 signaling to cardiac dysfunction after global myocardial ischemia.

C. Dinarello, Xianzhong Meng, L. Ao, 2008, The Annals of thoracic surgery.

Monocytes augment inflammatory responses in human aortic valve interstitial cells via β2-integrin/ICAM-1-mediated signaling

Xianzhong Meng, L. Ao, D. Fullerton, 2022, Inflammation Research.

Adrenergic induction of bimodal myocardial protection: signal transduction and cardiac gene reprogramming.

A. Harken, D. Meldrum, Xianzhong Meng, 1999, American journal of physiology. Regulatory, integrative and comparative physiology.

Adrenergic induction of bimodal myocardial protection: signal transduction and cardiac gene reprogramming.

A. Harken, D. Meldrum, L. Ao, 1999, The American journal of physiology.

Trimethylamine -N-oxide induces osteogenic responses in human aortic valve interstitial cells in vitro and aggravates aortic valve lesions in mice.

Xianzhong Meng, L. Ao, H. Ren, 2021, Cardiovascular research.

NITRIC OXIDE SYNTHASE IS NOT INVOLVED IN CARDIAC CONTRACTILE DYSFUNCTION IN A RAT MODEL OF ENDOTOXEMIA WITHOUT SHOCK

A. Harken, Xianzhong Meng, L. Ao, 1997, Shock.

Ghrelin reduces myocardial injury following global ischemia and reperfusion via suppression of myocardial inflammatory response

J. Cleveland, Xianzhong Meng, L. Ao, 2013 .

TNF-alpha-dependent bilateral renal injury is induced by unilateral renal ischemia-reperfusion.

A. Harken, K. Meldrum, D. Meldrum, 2002, American journal of physiology. Heart and circulatory physiology.

Myocardial TLR 4 is a determinant of neutrophil infiltration after global myocardial ischemia : mediating KC and MCP-1 expression induced by extracellular HSC 70

J. Cleveland, Xianzhong Meng, L. Ao, 2009 .

ytokines Link Toll-Like Receptor 4 Signaling to ardiac Dysfunction After Global Myocardial

Xianzhong Meng, L. Ao, A. Banerjee, 2008 .

Vascular cell adhesion molecule--1 expression is obligatory for endotoxin-induced myocardial neutrophil accumulation and contractile dysfunction.

A. Harken, L. Ao, A. Banerjee, 2001, Surgery.

Human Myocardium Releases Heat Shock Protein 27 (HSP27) after Global Ischemia: The Proinflammatory Effect of Extracellular HSP27 through Toll-like Receptor (TLR)-2 and TLR4

J. Cleveland, Xianzhong Meng, L. Ao, 2014, Molecular medicine.

Single-cell RNA-seq reveals a critical role of novel pro-inflammatory EndMT in mediating adverse remodeling in coronary artery–on–a–chip

C. Dinarello, Xianzhong Meng, L. Ao, 2021, Science Advances.

An epigenetic regulatory loop controls pro-osteogenic activation by TGF-β1 or bone morphogenetic protein 2 in human aortic valve interstitial cells

Xianzhong Meng, L. Ao, D. Fullerton, 2017, The Journal of Biological Chemistry.

Double-stranded RNA upregulates the expression of inflammatory mediators in human aortic valve cells through the TLR3-TRIF-noncanonical NF-κB pathway.

Xianzhong Meng, L. Ao, D. Fullerton, 2017, American journal of physiology. Cell physiology.

Preconditioning of isolated rat heart is mediated by protein kinase C.

A. Harken, Xianzhong Meng, L. Ao, 1995, Circulation research.

BMP-2 and TGF-β1 mediate biglycan-induced pro-osteogenic reprogramming in aortic valve interstitial cells

Xianzhong Meng, L. Ao, D. Fullerton, 2015, Journal of Molecular Medicine.

Soluble biglycan induces the production of ICAM-1 and MCP-1 in human aortic valve interstitial cells through TLR2/4 and the ERK1/2 pathway

Xianzhong Meng, L. Ao, D. Fullerton, 2014, Inflammation Research.

Interleukin 38 alleviates aortic valve calcification by inhibition of NLRP3

C. Dinarello, Xianzhong Meng, L. Ao, 2022, Proceedings of the National Academy of Sciences of the United States of America.

Altered MicroRNA Expression Is Responsible for the Pro‐Osteogenic Phenotype of Interstitial Cells in Calcified Human Aortic Valves

J. Cleveland, Xianzhong Meng, L. Ao, 2017, Journal of the American Heart Association.

Bone morphogenic protein 2 induces Runx2 and osteopontin expression in human aortic valve interstitial cells: role of Smad1 and extracellular signal-regulated kinase 1/2.

Xiaoping Yang, J. Cleveland, Xiaoping Yang, 2009, The Journal of thoracic and cardiovascular surgery.

Monocytes enhance the inflammatory response to TLR2 stimulation in aortic valve interstitial cells through paracrine up-regulation of TLR2 level

Balachandar Nedumaran, Xianzhong Meng, L. Ao, 2020, International journal of biological sciences.

Activation of TLR3 Induces Osteogenic Responses in Human Aortic Valve Interstitial Cells through the NF-κB and ERK1/2 Pathways

Xianzhong Meng, L. Ao, D. Fullerton, 2015, International journal of biological sciences.

Critical role of extracellular heat shock cognate protein 70 in the myocardial inflammatory response and cardiac dysfunction after global ischemia-reperfusion.

J. Cleveland, Xianzhong Meng, L. Ao, 2008, American journal of physiology. Heart and circulatory physiology.

Activation state of stromal inflammatory cells in murine metastatic pancreatic adenocarcinoma.

E. Moore, C. Silliman, Xianzhong Meng, 2012, American journal of physiology. Regulatory, integrative and comparative physiology.

Enhanced inflammatory responses to toll-like receptor 2/4 stimulation in type 1 diabetic coronary artery endothelial cells: the effect of insulin

J. Cleveland, Xianzhong Meng, L. Ao, 2010, Cardiovascular diabetology.

Lung cancer cell invasion and expression of intercellular adhesion molecule-1 (ICAM-1) are attenuated by secretory phospholipase A₂ inhibition.

M. Weyant, Xianzhong Meng, L. Ao, 2012, The Journal of thoracic and cardiovascular surgery.

Inhibition of secretory phospholipase A2 IIa attenuates prostaglandin E2-induced invasiveness in lung adenocarcinoma

M. Weyant, J. Rove, Xianzhong Meng, 2019, Molecular and Cellular Biochemistry.

Inhibition of secretory phospholipase A2 IIa attenuates prostaglandin E2-induced invasiveness in lung adenocarcinoma

M. Weyant, J. Rove, Xianzhong Meng, 2019, Molecular and Cellular Biochemistry.

Mechanistic Roles of Matrilin-2 and Klotho in Modulating the Inflammatory Activity of Human Aortic Valve Cells

Xianzhong Meng, L. Ao, D. Fullerton, 2020, Cells.

Interleukin-37 suppresses the osteogenic responses of human aortic valve interstitial cells in vitro and alleviates valve lesions in mice

J. Cleveland, T. McKinsey, C. Dinarello, 2017, Proceedings of the National Academy of Sciences.

ADAMTS5 Deficiency in Calcified Aortic Valves Is Associated With Elevated Pro-Osteogenic Activity in Valvular Interstitial Cells

J. Cleveland, Xianzhong Meng, L. Ao, 2017, Arteriosclerosis, thrombosis, and vascular biology.

Influence of Aluminum at Low pH on the Rhizosphere Processes of Masson Pine (Pinus Massoniana Lamb)

W. Ping, L. Ao, Zhou Sijie, 2021 .

DITPA, a thyroid hormone analog, reduces infarct size and attenuates the inflammatory response following myocardial ischemia.

Xianzhong Meng, L. Ao, Jilin Li, 2011, The Journal of surgical research.

ASSOCIATION FOR ACADEMIC SURGERY DITPA, AThyroid Hormone Analog, Reduces Infarct Size and Attenuates the Inflammatory Response Following Myocardial Ischemia

Xianzhong Meng, L. Ao, Jilin Li, 2011 .

Neurotrophin 3 upregulates proliferation and collagen production in human aortic valve interstitial cells: a potential role in aortic valve sclerosis.

J. Cleveland, Xianzhong Meng, L. Ao, 2017, American journal of physiology. Cell physiology.

A single endotoxin challenge induces delayed myocardial protection against infarcation.

A. Harken, L. Ao, R. T. Rowland, 1996, The Journal of surgical research.

Interleukin-10 inhibits postinjury tumor necrosis factor-mediated human vascular smooth muscle proliferation.

A. Harken, D. Meldrum, L. Ao, 1998, The Journal of surgical research.

A low level of TNF-alpha mediates hemorrhage-induced acute lung injury via p55 TNF receptor.

A. Harken, E. Abraham, L. Ao, 2001, American journal of physiology. Lung cellular and molecular physiology.

Post-transcriptional regulation of TNF-induced expression of ICAM-1 and IL-8 in human lung microvascular endothelial cells: an obligatory role for the p38 MAPK-MK2 pathway dissociated with HSP27.

Xiaoping Yang, Xianzhong Meng, L. Ao, 2008, Biochimica et biophysica acta.

Pro-inflammatory mediators released by activated monocytes promote aortic valve fibrocalcific activity

Xianzhong Meng, L. Ao, D. Fullerton, 2022, Molecular medicine.

Interleukin‐37 suppresses the inflammatory response to protect cardiac function in old endotoxemic mice

C. Dinarello, Xianzhong Meng, L. Ao, 2017, Cytokine.

Up-regulation of Myocardial Klotho Expression to Promote Cardiac Functional Recovery in Old Mice following Endotoxemia

Xianzhong Meng, L. Ao, D. Fullerton, 2023, Research square.

Soluble biglycan induces the production of ICAM-1 and MCP-1 in human aortic valve interstitial cells through TLR2/4 and the ERK1/2 pathway

Xianzhong Meng, L. Ao, D. Fullerton, 2014, Inflammation Research.

Attenuated Recovery of Contractile Function in Aging Hearts Following Global Ischemia/Reperfusion: Role of Extracellular HSP27 and TLR4

J. Cleveland, Xianzhong Meng, L. Ao, 2016, Molecular medicine.

Interleukin 6 production during cardiac surgery correlates with increasing age.

J. Cleveland, R. Schwartz, Xianzhong Meng, 2016, The Journal of surgical research.

Toll-like receptor 4 mediates oxidized - LDL induced macrophage differentiation to foam cells

Xianzhong Meng, L. Ao, D. Fullerton, 2010 .

Intercellular adhesion molecule-1 mediates murine colon adenocarcinoma invasion.

B. Edil, R. Schulick, L. Ao, 2013, The Journal of surgical research.

Abstract 8603: Expression of Human Interleukine-37 Protects Mouse Heart Against Ischemic Injury Through Suppression of Monocyte Chemoattractant Protein-1-Mediated Mononuclear Cell Accumulation

C. Dinarello, Xianzhong Meng, L. Ao, 2011, Circulation.

Ligation of ICAM-1 on human aortic valve interstitial cells induces the osteogenic response: A critical role of the Notch1-NF-κB pathway in BMP-2 expression.

Xianzhong Meng, L. Ao, D. Fullerton, 2014, Biochimica et biophysica acta.

TNF-alpha and myocardial depression in endotoxemic rats: temporal discordance of an obligatory relationship.

A. Harken, D. Meldrum, L. Ao, 1998, The American journal of physiology.

Differential cardiopulmonary recruitment of neutrophils during hemorrhagic shock: a role for ICAM-1?

A. Harken, L. Ao, X. Meng, 2001, Shock.

P504Critical role IL-37 to ameliorate endotoxemic cardiac depression in aging mice: a critical role of suppression cardiodepressant cytokines

C. Dinarello, Xianzhong Meng, L. Ao, 2014 .

Recombinant IL-37 Exerts an Anti-inflammatory Effect on Human Aortic Valve Interstitial Cells through Extracellular and Intracellular Actions

C. Dinarello, Xianzhong Meng, L. Ao, 2023, International journal of biological sciences.

TLR4 mediates LPS-induced HO-1 expression in mouse liver: role of TNF-alpha and IL-1beta.

A. Harken, Xianzhong Meng, L. Ao, 2003, World journal of gastroenterology.

Attenuated Recovery of Contractile Function in Aging Hearts Following Global Ischemia/Reperfusion: Role of Extracellular HSP27 and TLR4

J. Cleveland, Xianzhong Meng, L. Ao, 2016, Molecular medicine.

Neurotrophin 3 upregulates proliferation and collagen production in human aortic valve interstitial cells: a potential role in aortic valve sclerosis.

J. Cleveland, Xianzhong Meng, L. Ao, 2017, American journal of physiology. Cell physiology.

Signaling for myocardial depression in hemorrhagic shock: roles of Toll-like receptor 4 and p55 TNF-alpha receptor.

A. Harken, L. Ao, C. Raeburn, 2005, American journal of physiology. Regulatory, integrative and comparative physiology.

Enhanced inflammatory responses to toll-like receptor 2/4 stimulation in type 1 diabetic coronary artery endothelial cells: the effect of insulin

J. Cleveland, Xianzhong Meng, L. Ao, 2010, Cardiovascular diabetology.

Bone morphogenic protein 2 induces Runx2 and osteopontin expression in human aortic valve interstitial cells: role of Smad1 and extracellular signal-regulated kinase 1/2.

J. Cleveland, Xiaoping Yang, Xianzhong Meng, 2009, The Journal of thoracic and cardiovascular surgery.

Biglycan Induces the Expression of Osteogenic Factors in Human Aortic Valve Interstitial Cells via Toll-Like Receptor-2

J. Cleveland, Xianzhong Meng, L. Ao, 2012, Arteriosclerosis, thrombosis, and vascular biology.

Activation state of stromal inflammatory cells in murine metastatic pancreatic adenocarcinoma.

E. Moore, C. Silliman, Xianzhong Meng, 2012, American journal of physiology. Regulatory, integrative and comparative physiology.

Aging exacerbates cardiac dysfunction and mortality in sepsis through enhancing TLR2 activity

Xianzhong Meng, L. Ao, Erlinda The, 2023, Frontiers in Cardiovascular Medicine.

Molecular Interaction of Soluble Klotho with FGF23 in the Pathobiology of Aortic Valve Lesions Induced by Chronic Kidney Disease

Xianzhong Meng, L. Ao, Erlinda The, 2024, International journal of biological sciences.