I. Deaciuc

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Interleukin-6 and Tumor Necrosis Factor-α Clearance and Metabolism In Vivo and by the Isolated, Perfused Liver in the Rat: Effect of Acute Alcohol Administration

I. Deaciuc, J. M. Alappat, K. Mcdonough, 1996 .

Effect of acute alcohol administration on TNF-alpha binding to neutrophils and isolated liver plasma membranes.

J. Spitzer, C. Lang, G. Bagby, 1992, Alcoholism, clinical and experimental research.

Integrated hepatic transcriptome and proteome analysis of mice with high-fat diet-induced nonalcoholic fatty liver disease.

Matt Cave, Craig J McClain, C. McClain, 2011, The Journal of nutritional biochemistry.

Clinical implications of oxidative stress and antioxidant therapy

C. McClain, G. Arteel, I. Deaciuc, 2005, Current gastroenterology reports.

Inhibition of adiponectin production by homocysteine: A potential mechanism for alcoholic liver disease

C. McClain, I. Deaciuc, Zhenyuan Song, 2008, Hepatology.

A role for interleukin-10 in alcohol-induced liver sensitization to bacterial lipopolysaccharide.

R. Burikhanov, I. Deaciuc, N. D'souza, 2002, Alcoholism, clinical and experimental research.

Alcohol-induced S-adenosylhomocysteine accumulation in the liver sensitizes to TNF hepatotoxicity: possible involvement of mitochondrial S-adenosylmethionine transport.

C. McClain, S. Uriarte, I. Deaciuc, 2007, Biochemical pharmacology.

Good fat/bad fat

C. McClain, S. Barve, I. Deaciuc, 2007, Hepatology.

Silymarin prevents palmitate-induced lipotoxicity in HepG2 cells: involvement of maintenance of Akt kinase activation.

C. McClain, I. Deaciuc, Zhenyuan Song, 2007, Basic & clinical pharmacology & toxicology.

Tumor necrosis factor-alpha internalization and degradation by isolated hepatocytes of rats exposed to ethanol.

D. V. van Thiel, C. McClain, I. Deaciuc, 1998, Alcohol.

MECHANISMS OF HEPATIC INJURY IN ALCOHOLIC LIVER DISEASE

A. Nanji, C. McClain, I. Deaciuc, 1998 .

A novel mechanism for Ca(2+)-dependent regulation of hepatic gluconeogenesis: stimulation of mitochondrial phosphoenolpyruvate synthesis by Ca2+.

I. Deaciuc, N. D'souza, H. Miller, 1992, The International journal of biochemistry.

Gram‐negative bacterial lipopolysaccharide impairs hyaluronan clearance in vivo and its uptake by the isolated, perfused rat liver

J. Spitzer, C. Lang, G. Bagby, 1993, Hepatology.

Activation of Cellular Membrane Receptors; Intracellular Messengers and Mediators of the Response to Injury

I. Deaciuc, J. A. Spitzer, E. Turco, 1990 .

Hepatic Responses to Bacterial Endotoxin (LPS)

H. Jaeschke, J. Spitzer, I. Deaciuc, 1993 .

Genome-wide transcriptome expression in the liver of a mouse model of high carbohydrate diet-induced liver steatosis and its significance for the disease

T. Knudsen, C. McClain, S. Barve, 2008, Hepatology international.

Apoptosis and dysregulated ceramide metabolism in a murine model of alcohol-enhanced lipopolysaccharide hepatotoxicity.

C. McClain, M. Nikolova-Karakashian, I. Deaciuc, 2000, Alcoholism, clinical and experimental research.

Regulation of glutamine catabolism in the perfused guinea-pig liver in relation to ureogenesis and gluconeogenesis.

I. Deaciuc, I. Petrescu, 1980, The International journal of biochemistry.

Mechanisms of non-alcoholic steatohepatitis.

C. McClain, S. Barve, I. Deaciuc, 2004, Alcohol.

Involvement of AMP-activated protein kinase in beneficial effects of betaine on high-sucrose diet-induced hepatic steatosis.

C. McClain, I. Deaciuc, Zhenyuan Song, 2007, American journal of physiology. Gastrointestinal and liver physiology.

Silymarin protects against acute ethanol-induced hepatotoxicity in mice.

C. McClain, I. Deaciuc, X. Ji, 2006, Alcoholism, clinical and experimental research.

Dysregulated cytokine metabolism, altered hepatic methionine metabolism and proteasome dysfunction in alcoholic liver disease.

C. McClain, S. Joshi‐Barve, S. Barve, 2005, Alcoholism, clinical and experimental research.

Dysregulated cytokine metabolism in alcoholic liver disease

C. McClain, S. Barve, I. Deaciuc, 2004 .

Recent advances in alcoholic liver disease. IV. Dysregulated cytokine metabolism in alcoholic liver disease.

C. McClain, S. Barve, I. Deaciuc, 2004, American journal of physiology. Gastrointestinal and liver physiology.

How is the liver primed or sensitized for alcoholic liver disease?

N. Enomoto, Y. Takei, C. McClain, 2001, Alcoholism, clinical and experimental research.

Monocyte activation in alcoholic liver disease.

C. McClain, S. Barve, I. Deaciuc, 2002, Alcohol.

Insulin-Like, Antilipolytic Effect of 12-O-Tetradecanoyl Phorbol 13-Acetate in Rat White Adipocytes

I. Deaciuc, J. A. Spitzer, 1991, Proceedings of the Society for Experimental Biology and Medicine. Society for Experimental Biology and Medicine.

Ethanol exposure modulates hepatic S-adenosylmethionine and S-adenosylhomocysteine levels in the isolated perfused rat liver through changes in the redox state of the NADH/NAD(+) system.

C. McClain, W. Watson, I. Deaciuc, 2011, Biochimica et biophysica acta.

Endotoxicosis modulates cytosolic free calcium and basal and ACTH-stimulated lipolysis in rat adipocytes.

I. Deaciuc, J. A. Spitzer, 1990, Cell calcium.

Kupffer cell inactivation prevents lipopolysaccharide‐induced structural changes in the rat liver sinusoid: An electron‐microscopic study

I. Deaciuc, N. D'souza, T. Sarphie, 1996, Hepatology.

Modification of protein kinase C (PKC) activity and diacylglycerol (DAG) accumulation in hepatocytes in continuous endotoxemia.

B. Roth, J. Hermiller, I. Deaciuc, 1989, Progress in clinical and biological research.

Alcohol modulates alveolar macrophage tumor necrosis factor-alpha, superoxide anion, and nitric oxide secretion in the rat.

W. Summer, I. Deaciuc, N. D'souza, 1996, Alcoholism, clinical and experimental research.

Modulation of hepatic sinusoidal endothelial cell function by Kupffer cells: An example of intercellular communication in the liver

J. Spitzer, G. Bagby, I. Deaciuc, 1994, Hepatology.

Epidermal growth factor protects the liver against alcohol-induced injury and sensitization to bacterial lipopolysaccharide.

C. McClain, R. Burikhanov, I. Deaciuc, 2002, Alcoholism, clinical and experimental research.

Inhibition of caspases in vivo protects the rat liver against alcohol-induced sensitization to bacterial lipopolysaccharide.

C. McClain, R. Burikhanov, I. Deaciuc, 2001, Alcoholism, clinical and experimental research.

Alcohol and cytokine networks.

I. Deaciuc, 1997, Alcohol.

Tumor necrosis factor-alpha cell-surface receptors of liver parenchymal and nonparenchymal cells during acute and chronic alcohol administration to rats.

J. Spitzer, I. Deaciuc, N. D'souza, 1995, Alcoholism, clinical and experimental research.

Modulation of caspase-3 activity and Fas ligand mRNA expression in rat liver cells in vivo by alcohol and lipopolysaccharide.

C. McClain, J. Schmidt, I. Deaciuc, 1999, Alcoholism, clinical and experimental research.

Lessons from large-scale gene profiling of the liver in alcoholic liver disease.

C. McClain, I. Deaciuc, Zhenyuan Song, 2005, Hepatology research : the official journal of the Japan Society of Hepatology.

Large-scale gene profiling of the liver in a mouse model of chronic, intragastric ethanol infusion.

A. Stromberg, R. Burikhanov, I. Deaciuc, 2004, Journal of hepatology.

Role of apoptosis in alcoholic liver injury.

A. Nanji, H. Ishii, M. Adachi, 2003, Alcoholism, clinical and experimental research.

Effect of chronic alcohol consumption by rats on tumor necrosis factor-α and interleukin-6 clearance in vivo and by the isolated, perfused liver

I. Deaciuc, J. M. Alappat, K. Mcdonough, 1996 .

Dose- and time-dependent effects of ethanol on functional and structural aspects of the liver sinusoid in the mouse.

D. V. van Thiel, C. McClain, I. Deaciuc, 1997, Alcoholism, clinical and experimental research.

Expression of tumor necrosis factor-alpha and interleukin-6 cell-surface receptors of the alveolar macrophage in alcohol-treated rats.

W. Summer, I. Deaciuc, N. D'souza, 1994, Alcoholism, clinical and experimental research.

Phosphorylation and hydrolysis of 7-deazaadenine nucleotides by rat liver and beef heart mitochondria.

O. Bârzu, I. Lascu, M. Markert, 1982, Biochemistry.

Effects of exogenous superoxide anion and nitric oxide on the scavenging function and electron microscopic appearance of the sinusoidal endothelium in the isolated, perfused rat liver.

C. McClain, J. Schmidt, I. Deaciuc, 1999, Journal of hepatology.

A new inhibitor of the long-chain fatty acid transfer across the mitochondrial membrane: 2-(3-methylcinnamylhydrazono)-propionate (BM 42.304).

I. Deaciuc, F. H. Schmidt, H. Kuhnle, 1985, Life sciences.

Lipopolysaccharide-induced liver apoptosis is increased in interleukin-10 knockout mice.

R. Burikhanov, I. Deaciuc, W. D. de Villiers, 2006, Biochimica et biophysica acta.

Interactions of cytokines, S‐adenosylmethionine, and S‐adenosylhomocysteine in alcohol‐induced liver disease and immune suppression

C. McClain, S. Joshi‐Barve, S. Barve, 2006, Journal of gastroenterology and hepatology.

Studies on the mechanism of action of the hypoglycemic agent, 2-(3-methylcinnamylhydrazono)-propionate (BM 42.304).

I. Deaciuc, F. H. Schmidt, H. Kühnle, 1983, Biochemical pharmacology.

Down-regulation of prostaglandin F2α receptors in rat liver during chronic endotoxemia

I. Deaciuc, J. A. Spitzer, 1991 .

Cytokines in Alcoholic Liver Disease

C. McClain, S. Barve, I. Deaciuc, 1999, Seminars in liver disease.

Hyaluronic acid uptake by the isolated, perfused rat liver: An index of hepatic sinusoidal endothelial cell function

J. Spitzer, C. Lang, G. Bagby, 1993, Hepatology.

Alterations in binding of inositol 1,4,5-trisphosphate to subcellular structures of rat liver during chronic endotoxemia.

I. Deaciuc, J. A. Spitzer, 1989, Cell calcium.

Calcium content in liver and heart and its intracellular distribution in liver during endotoxicosis and sepsis in rats.

I. Deaciuc, J. A. Spitzer, 1987, Cell calcium.

Hepatic sinusoidal endothelial cell in alcoholemia and endotoxemia.

J. Spitzer, I. Deaciuc, 1996, Alcoholism, clinical and experimental research.

The regulation of Fas (CD95/Apo-1)-mediated liver apoptosis in Kupffer cell-depleted mice.

C. McClain, M. Nikolova-Karakashian, I. Deaciuc, 2002, Hepatology research : the official journal of the Japan Society of Hepatology.

Effect of acute and chronic alcohol administration to rats on the expression of interleukin-6 cell-surface receptors of hepatic parenchymal and nonparenchymal cells.

I. Deaciuc, J. M. Alappat, N. D'souza, 1994, Alcoholism, clinical and experimental research.

Modulation of endotoxin stimulated interleukin-6 production in monocytes and Kupffer cells by S-adenosylmethionine (SAMe).

C. McClain, S. Uriarte, S. Barve, 2004, Cytokine.

Interrelationships between gluconeogenesis and uricogenesis in chicken liver.

M. Papadakis, I. Deaciuc, I. Petrescu, 1982, The International journal of biochemistry.

In vivo and in vitro effects of a new hypoglycemic agent, 2-(3-methylcinnamylhydrazono)-propionate (BM 42.304) on glucose metabolism in guinea pigs.

I. Deaciuc, F. H. Schmidt, H. Kühnle, 1984, Biochemical pharmacology.

Relationships between phosphoenolpyruvate synthesis and glutamine formation in isolated chicken liver mitochondria.

M. Papadakis, I. Deaciuc, 1984, Comparative biochemistry and physiology. B, Comparative biochemistry.

Effect of adenosine on gluconeogenesis in the perfused liver of chicken and guinea-pig.

I. Deaciuc, A. Ilonca, 1981, The International journal of biochemistry.

Effect of indole type compounds on gluconeogenesis in guinea-pig liver.

H. Mantsch, O. Bârzu, I. Deaciuc, 1979, The International journal of biochemistry.

Gene expression in the liver of rats fed alcohol by means of intragastric infusion.

C. McClain, G. Arteel, I. Deaciuc, 2004, Alcohol.

Effects of acute alcohol intoxication on gluconeogenesis and its hormonal responsiveness in isolated, perfused rat liver.

J. Spitzer, C. Lang, I. Deaciuc, 1992, Biochemical pharmacology.

Hyperhyaluronanemia in alcoholic hepatitis is associated with increased levels of circulating soluble intercellular adhesion molecule-1.

C. McClain, I. Deaciuc, D. Hill, 1998, Alcoholism, clinical and experimental research.

Tumor necrosis factor and alcoholic liver disease.

C. McClain, S. Barve, I. Deaciuc, 1998, Alcoholism, clinical and experimental research.

Ethanol alters the metabolic response of isolated perfused rat liver to a phagocytic stimulus.

J. Spitzer, C. Lang, G. Bagby, 1993, Alcoholism, clinical and experimental research.

Nonalcoholic fatty liver disease: predisposing factors and the role of nutrition.

C. McClain, S. Joshi‐Barve, S. Barve, 2007, The Journal of nutritional biochemistry.

Alcohol consumption in rats potentiates the deleterious effect of gram-negative sepsis on hepatic hyaluronan uptake.

J. Spitzer, G. Bagby, I. Deaciuc, 1993, Alcoholism, clinical and experimental research.

Microarray gene analysis of the liver in a rat model of chronic, voluntary alcohol intake.

R. Burikhanov, I. Deaciuc, N. D'souza, 2004, Alcohol.

Regulation of gluconeogenesis from propionate and propanol in the perfused guinea pig liver.

I. Deaciuc, S. G. Kessaris, 1978, The International journal of biochemistry.

Liver sinusoid during chronic alcohol consumption in the rat: an electron microscopic study.

J. Spitzer, I. Deaciuc, N. D'souza, 1995, Alcoholism, clinical and experimental research.

Effect of silymarin on experimental liver lesions.

I. Deaciuc, C. Coţutiu, N. Părău, 1981, Medecine interne.

Alcohol, but not lipopolysaccharide-induced liver apoptosis involves changes in intracellular compartmentalization of apoptotic regulators.

C. McClain, R. Burikhanov, I. Deaciuc, 2004, Alcoholism, clinical and experimental research.

Chronic alcohol exposure of rats exacerbates apoptosis in hepatocytes and sinusoidal endothelial cells.

C. McClain, I. Deaciuc, N. D'souza, 2001, Hepatology research : the official journal of the Japan Society of Hepatology.

IP3-dependent Ca2+ release in permeabilized hepatocytes of endotoxemic and septic rats.

I. Deaciuc, J. A. Spitzer, 1987, The American journal of physiology.

Prostaglandin F2α stimulates gluconeogenesis in the perfused rat liver and this effect is blunted in livers from endotoxin infused rats

I. Deaciuc, J. A. Spitzer, 1990, Agents and Actions.

Alcohol-induced hepatic sinusoidal endothelial cell dysfunction in the mouse is mediated by Kupffer cells

J. Spitzer, I. Deaciuc, N. D'souza, 1995 .

Chronic alcohol feeding in liquid diet or in drinking water has similar effects on electron microscopic appearance of the hepatic sinusoid in the rat.

J. Spitzer, I. Deaciuc, N. D'souza, 1996, Alcoholism, clinical and experimental research.

Acute alcohol administration to mice induces hepatic sinusoidal endothelial cell dysfunction

J. Spitzer, J. Shellito, I. Deaciuc, 1994 .

Hyaluronic acid uptake by the isolated, perfused rat liver: An index of hepatic sinusoidal endothelial cell function

J. Spitzer, C. Lang, G. Bagby, 1993, Hepatology.

Further characterization of a model of chronic endotoxemia in the rat: adenine nucleotide content in liver.

I. Deaciuc, J. A. Spitzer, 1988, Circulatory shock.

4‐Hydroxynonenal‐induced apoptosis in rat hepatic stellate cells: Mechanistic approach

C. McClain, I. Deaciuc, W. D. de Villiers, 2007, Journal of gastroenterology and hepatology.

Effect of endotoxicosis and sepsis on intracellular calcium homeostasis in rat liver. Mitochondrial and microsomal calcium uptake.

I. Deaciuc, J. A. Spitzer, 1986, Circulatory shock.

Effect of subcutaneous Escherichia coli-induced hypermetabolic sepsis on hepatic gluconeogenesis and its hormonal responsiveness in the rat.

J. Spitzer, C. Lang, G. Bagby, 1993, Circulatory shock.

Perturbation of transmembrane signaling mechanisms in acute and chronic endotoxemia.

B. Roth, I. Deaciuc, J. A. Spitzer, 1987, Progress in clinical and biological research.

Inhibition of adiponectin production by homocysteine: A potential mechanism for alcoholic liver disease

C. McClain, I. Deaciuc, Zhenyuan Song, 2008, Hepatology.

Association of galactosamine-induced hepatitis in the rat with hyperhyaluronanaemia and decreased hyaluronan uptake by the isolated, perfused liver.

J. Spitzer, G. Bagby, I. Deaciuc, 1993, Biochemical pharmacology.