G. Hedlund

发表

Linomide, a novel immunomodulator that prevents death in four models of septic shock

G. Kroemer, C. Martínez-A, J. Gonzalo, 1993, European journal of immunology.

The new orally active immunoregulator laquinimod (ABR-215062) effectively inhibits development and relapses of experimental autoimmune encephalomyelitis

G. Hedlund, L. Ohlsson, T. Brodin, 2002, Journal of Neuroimmunology.

Phase I dose escalation, pharmacokinetic and pharmacodynamic study of naptumomab estafenatox alone in patients with advanced cancer and with docetaxel in patients with advanced non-small-cell lung cancer.

H. Borghaei, C. Langer, K. Alpaugh, 2009, Journal of clinical oncology : official journal of the American Society of Clinical Oncology.

Tumor‐Targeted Superantigens

G. Hedlund, M. Nilsson, A. Sundstedt, 2013 .

Immunotherapy with tumor-targeted superantigens (TTS) in combination with docetaxel results in synergistic anti-tumor effects.

G. Hedlund, A. Sundstedt, G. Forsberg, 2009, International immunopharmacology.

Roquinimex inhibits dextran sodium sulfate-induced murine colitis

G. Hedlund, H. Thorlacius, Q. Liu, 2003, Inflammation Research.

Naptumomab Estafenatox, an Engineered Antibody-superantigen Fusion Protein With Low Toxicity and Reduced Antigenicity

G. Hedlund, G. Forsberg, T. Nederman, 2010, Journal of immunotherapy.

Low CD86 Expression in the Nonobese Diabetic Mouse Results in the Impairment of Both T Cell Activation and CTLA-4 Up-Regulation

G. Hedlund, E. Dahlén, K. Dawe, 2000, The Journal of Immunology.

A Randomized Phase II/III Study of Naptumomab Estafenatox + IFNα versus IFNα in Renal Cell Carcinoma: Final Analysis with Baseline Biomarker Subgroup and Trend Analysis

M. Gore, G. Hedlund, R. Hawkins, 2016, Clinical Cancer Research.

Superantigen‐induced cytokines suppress growth of human colon‐carcinoma cells

M. Björklund, T. Kalland, G. Hedlund, 1993, International journal of cancer.

Dendritic cells and macrophages are the first and major producers of TNF-alpha in pancreatic islets in the nonobese diabetic mouse.

G. Hedlund, L. Ohlsson, E. Dahlén, 1998, Journal of immunology.

The immunomodulator Linomide: role in treatment and prevention of autoimmune diabetes mellitus.

G. Hedlund, S. Slavin, M. Rapoport, 2001, International immunopharmacology.

Linomide (roquinimex) affects the balance between pro‐ and anti‐inflammatory cytokines in vitro in multiple sclerosis

G. Hedlund, H. Link, S. Fredrikson, 1998, Acta neurologica Scandinavica.

Diabetic Mouse in Pancreatic α and Major Producers of TNF-Dendritic Cells and Macrophages Are the First

G. Hedlund, L. Ohlsson, E. Dahlén, 1998 .

Activation of alloreactive natural killer cells is resistant to cyclosporine.

G. Hedlund, M. Dohlsten, H. Ekberg, 1997, Transplantation.

Self-MHC class Ia (RT1-A(n)) protects cells co-expressing the activatory allogeneic MHC class Ib molecule (RT1-E(u)) from NK lysis.

G. Hedlund, G. Butcher, E. Bäckman-Petersson, 2000, International immunology.

Effects of Linomide on immune cells and cytokines inhibit autoimmune pathologies of the central and peripheral nervous system.

G. Hedlund, H. Link, B. Xiao, 2001, International immunopharmacology.

Linomide suppresses both Th1 and Th2 cytokines in experimental autoimmune myasthenia gravis

F. Shi, G. Hedlund, H. Link, 1997, Journal of Neuroimmunology.

Gene transfer of a hybrid interleukin-1β gene to B16 mouse melanoma recruits leucocyte subsets and reduces tumour growth in vivo

G. Hedlund, A. Wingren, M. Dohlsten, 1997, Cancer Immunology, Immunotherapy.

Linomide inhibits insulitis and modulates cytokine production in pancreatic islets in the nonobese diabetic mouse.

G. Hedlund, H. Hall, L. Ohlsson, 2003, International immunopharmacology.

Up-RegulationBoth T Cell Activation and CTLA-4 Diabetic Mouse Results in the Impairment of Low CD86 Expression in the Nonobese

G. Hedlund, E. Dahlén, K. Dawe, 2000 .

The tumour associated cell surface antigen A6H is costimulatory for human CD4+ but not CD8+ T cells

E. Parra, T. Kalland, G. Hedlund, 1997, Immunology.

regulates LFA-3-induced NF-AT DNA binding. interleukin-2 promoter: B7-1 negatively distinct nuclear factors that bind to the Costimulation by B7-1 and LFA-3 targets

E. Parra, T. Kalland, G. Hedlund, 2013 .

Costimulation by B7-1 and LFA-3 targets distinct nuclear factors that bind to the interleukin-2 promoter: B7-1 negatively regulates LFA-3-induced NF-AT DNA binding

E. Parra, T. Kalland, G. Hedlund, 1997, Molecular and cellular biology.

Linomide suppresses chronic-relapsing experimental autoimmune encephalomyelitis in DA rats

G. Hedlund, B. Wahrén, Jie Zhu, 1998, Journal of the Neurological Sciences.

Induction of interleukin-1 in human monocytes by the superantigen staphylococcal enterotoxin A requires the participation of T cells.

J. Hansson, H. Sjögren, G. Hedlund, 1991, Cellular immunology.

Costimulation of human CD4+ T lymphocytes with B7 and lymphocyte function-associated antigen-3 results in distinct cell activation profiles.

M. Björklund, E. Parra, H. Sjögren, 1994, Journal of immunology.

Combined activation of murine lymphocytes with staphylococcal enterotoxin and interleukin-2 results in additive cytotoxic activity

T. Kalland, G. Hedlund, M. Dohlsten, 1994, Cancer Immunology, Immunotherapy.

Immunological response and overall survival in a subset of advanced renal cell carcinoma patients from a randomized phase 2/3 study of naptumomab estafenatox plus IFN-α versus IFN-α

G. Hedlund, D. Burt, R. Hawkins, 2015, Oncotarget.

Production of TNF-alpha and TNF-beta by staphylococcal enterotoxin A activated human T cells.

U. Andersson, J. Hansson, H. Sjögren, 1990, Journal of immunology.

Linomide suppresses acute experimental autoimmune encephalomyelitis in Lewis rats by counter-acting the imbalance of pro-inflammatory versus anti-inflammatory cytokines

G. Hedlund, B. Wahrén, Jie Zhu, 1998, Journal of Neuroimmunology.

Suppression of experimental autoimmune neuritis by ABR-215062 is associated with altered Th1/Th2 balance and inhibited migration of inflammatory cells into the peripheral nerve tissue

B. Winblad, G. Hedlund, B. Wahren, 2002, Neuropharmacology.

Gamma Interferon Induces the Appearance of a CD4‐, Major Histocompatibility Complex Class II+ Macrophage Subpopulation in the Rat Peritoneal Cavity

H. Sjögren, G. Hedlund, M. Dohlsten, 1989, Scandinavian journal of immunology.

The inhibitory effect in experimental autoimmune encephalomyelitis by the immunomodulatory drug Linomide (PNU-212616) is not mediated via release of endogenous glucocorticoids.

G. Hedlund, J. Björk, G. Andersson, 1998, Autoimmunity.

In vivo anergized CD4+ T cells express perturbed AP-1 and NF-kappa B transcription factors.

M. Sigvardsson, T. Leanderson, T. Kalland, 1996, Proceedings of the National Academy of Sciences of the United States of America.

Human major histocompatibility complex class II‐negative colon carcinoma cells present staphylococcal superantigens to cytotoxic T lymphocytes: evidence for a novel enterotoxin receptor

T. Kalland, G. Hedlund, A. Kelly, 1991, European journal of immunology.

Synergistic Action of Gamma Interferon and Catalase to Reverse the Suppressive Effect of Peritoneal Macrophages on Concanavalin A‐Induced Lymphocyte Proliferation

H. Sjögren, G. Hedlund, T. Diamantstein, 1986, Scandinavian journal of immunology.

T cell killing of human colon carcinomas by monoclonal-antibody-targeted superantigens

T. Kalland, G. Hedlund, M. Dohlsten, 2005, Cancer Immunology, Immunotherapy.

Activation of donor-specific CTL in a tolerant recipient of cardiac allograft.

G. Hedlund, H. Ekberg, Z. Qi, 1998, Cellular immunology.

Bacterial superantigens as anti-tumour agents: induction of tumour cytotoxicity in human lymphocytes by staphylococcal enterotoxin A

T. Kalland, G. Hedlund, M. Dohlsten, 2005, Cancer Immunology, Immunotherapy.

Staphylococcal enterotoxins direct and trigger CTL killing of autologous HLA-DR+ mononuclear leukocytes and freshly prepared leukemia cells.

T. Kalland, G. Hedlund, M. Dohlsten, 1990, Cellular immunology.

Superantigen-based tumor therapy: in vivo activation of cytotoxic T cells

T. Kalland, G. Hedlund, M. Dohlsten, 2005, Cancer Immunology, Immunotherapy.

A recombinant C-terminal fragment of staphylococcal enterotoxin A binds to human MHC class II products but does not activate T cells.

H. Macdonald, H. Sjögren, T. Kalland, 1991, Journal of immunology.

Magnetic carbohydrate nanoparticles for affinity cell separation.

H. Sjögren, G. Hedlund, C. Borrebaeck, 1986, Journal of immunological methods.

Activation and selection of NK cells via recognition of an allogeneic, non‐classical MHC class I molecule, RT1‐E

R. Holmdahl, G. Hedlund, G. Butcher, 1999, European journal of immunology.

Increased proportion of CD4+CDw29+CD45R-UCHL-1+ lymphocytes in the cerebrospinal fluid of both multiple sclerosis patients and healthy individuals.

M. Sandberg‐Wollheim, H. Sjögren, G. Hedlund, 1989, Cellular immunology.

Linomide inhibits programmed cell death of peripheral T cells in vivo

G. Kroemer, C. Martínez-A, T. Kalland, 1994, European journal of immunology.

Targeting of superantigens

L. Abrahmsén, T. Kalland, G. Hedlund, 2009, Cell Biophysics.

Monoclonal antibodies and superantigens: A novel therapeutic approach

T. Kalland, G. Hedlund, A. Sundstedt, 1993, Medical oncology and tumor pharmacotherapy.

Laquinimod (ABR-215062) suppresses the development of experimental autoimmune encephalomyelitis, modulates the Th1/Th2 balance and induces the Th3 cytokine TGF-β in Lewis rats

G. Hedlund, H. Link, B. Xiao, 2004, Journal of Neuroimmunology.

Expression of CD11a and CD45R Isoforms Defines Distinct Subsets of CD8+ TCRαβ and TCRγδ CTL in vivo

J. Hansson, H. Sjögren, G. Hedlund, 1995, Immunological reviews.

Role of the adhesion molecule ICAM‐1 (CD54) in staphylococcal enterotoxin‐mediated cytotoxicity

J. Trowsdale, D. Altmann, M. Patarroyo, 1991, European journal of immunology.

Stimulation of human naive and memory T helper cells with bacterial superantigen. Naive CD4+45RA+ T cells require a costimulatory signal mediated through the LFA-1/ICAM-1 pathway.

H. Sjögren, H. Hedman, T. Kalland, 1992, Journal of immunology.

Linomide Enhances Apoptosis in CD4+CD8+ Thymocytes

G. Hedlund, Z. Xu, G. Andersson, 1997, Scandinavian journal of immunology.

Locally superantigen-activated peritoneal cytolytic T lymphocytes belong to the CD8+ CD45RC- subset and lyse MHC class II+ tumor cells.

J. Hansson, H. Sjögren, T. Kalland, 1992, Immunology letters.

Inhibition of Autoimmune Disease by the Immunomodulator Linomide Correlates with the Ability to Activate Macrophages

G. Hedlund, M. Andersson, A. Björk, 2000, Autoimmunity.

Monocyte-regulated IFN-gamma production in human T cells involves CD2 signaling.

M. Björklund, T. Olsson, H. Sjögren, 1993, Journal of immunology.

Linomide-mediated protection of oligodendrocytes is associated with inhibition of nitric oxide production and IL-1β expression in Lewis rat glial cells

G. Hedlund, H. Link, B. Xiao, 1998, Neuroscience Letters.

Distinct splicing of CD45 mRNA in activated rat γδ cytotoxic T lymphocytes

J. Hansson, H. Sjögren, G. Hedlund, 1995 .

Co-stimulation with B7 and targeted superantigen is required for MHC class II-independent T-cell proliferation but not cytotoxicity.

T. Kalland, G. Hedlund, M. Dohlsten, 1993, Immunology.

Combining tumor-targeted superantigens with interferon-alpha results in synergistic anti-tumor effects.

G. Hedlund, A. Sundstedt, Mona Celander, 2008, International immunopharmacology.

Human Naive and Memory T‐Helper Cells Display Distinct Adhesion Properties to ICAM‐1, LFA‐3 and B7 Molecules

E. Parra, T. Kalland, G. Hedlund, 1993, Scandinavian journal of immunology.

Preparation and characterization of conjugates of monoclonal antibodies and staphylococcal enterotoxin A using a new hydrophilic cross-linker.

T. Kalland, G. Hedlund, M. Dohlsten, 1993, Bioconjugate chemistry.

Linomide-induced suppression of experimental autoimmune neuritis is associated with down-regulated macrophage functions

F. Shi, G. Hedlund, Jie Zhu, 1997, Journal of Neuroimmunology.

Proliferation of human CD4+45R+ and CD4+45R- T helper cells is promoted by both IL-2 and IL-4 while interferon-gamma production is restricted to IL-2 activated CD4+45R- T cells.

H. Sjögren, G. Hedlund, M. Dohlsten, 1989, Immunology letters.

Selective Cytotoxicity of Two Rodent T Cell Lymphomas to Rat Yolk Sac Tumours Involves a Retroviral Envelope Protein Expressed by the Lymphoma

H. Sjögren, M. Lindvall, G. Hedlund, 1997, Scandinavian journal of immunology.

Prevention of superantigen-induced tolerance in vivo by interleukin-2 treatment

T. Kalland, G. Hedlund, M. Dohlsten, 1997, Cancer Immunology, Immunotherapy.

Monoclonal antibody-superantigen fusion proteins: tumor-specific agents for T-cell-based tumor therapy.

L. Abrahmsén, G. Hedlund, C. Förberg, 1994, Proceedings of the National Academy of Sciences of the United States of America.

Staphylococcal enterotoxin-dependent cell-mediated cytotoxicity.

T. Kalland, G. Hedlund, M. Dohlsten, 1991, Current topics in microbiology and immunology.

The immune modulator Linomide prevents neuronal death in injured peripheral nerves of the mouse

G. Hedlund, P. Ekström, G. Andersson, 1998, Neuroreport.

T cell activation pathways: B7, LFA-3, and ICAM-1 shape unique T cell profiles.

E. Parra, H. Sjögren, T. Kalland, 1995, Critical reviews in immunology.

Superantigen-induced anergy in cytotoxic CD8+ T cells.

J. Hansson, T. Kalland, G. Hedlund, 1995, Journal of immunology.

The LFA‐3 Adhesion Pathway is Differently Utilized by Superantigen‐Activated Human CD4+ T‐Cell Subsets

J. Trowsdale, T. Kalland, G. Hedlund, 1992, Scandinavian journal of immunology.

Immunopharmacology of the superantigen staphylococcal enterotoxin A in T-cell receptor V beta 3 transgenic mice.

M. Björklund, T. Kalland, G. Hedlund, 1993, Immunology.

Functions of rat CD4+ T cell subsets defined by CD45RB: CD45RB- cells have a much stronger response to recall antigens, whereas polyclonally activated cells of both subsets are equally efficient producers of IFN in the presence of exogenous IL-2.

G. Hedlund, M. Dohlsten, P. Ericsson, 1991, Cellular immunology.

Malignant parotid tumors in patients previously treated for childhood cancer: clinical and imaging findings in eight cases.

S. Kaste, C. Pratt, G. Hedlund, 1994, AJR. American journal of roentgenology.

Phenotypical and Functional Differentiation of CD4+ CD45RA+ Human T Cells Following Polyclonal Activation

G. Hedlund, M. Dohlsten, R. Carlsson, 1990, Scandinavian journal of immunology.

Monoclonal antibody-targeted superantigens: a different class of anti-tumor agents.

T. Kalland, G. Hedlund, M. Dohlsten, 1991, Proceedings of the National Academy of Sciences of the United States of America.

Targeting of human cytotoxic T lymphocytes to MHC class II-expressing cells by staphylococcal enterotoxins.

J. Trowsdale, T. Kalland, G. Hedlund, 1990, Immunology.

Inhibitory Effects of Histamine on Interleukin 2 and Gamma Interferon Production by Different Human T Helper Cell Subsets

G. Hedlund, M. Dohlsten, R. Carlsson, 1988, Scandinavian journal of immunology.

Maximal interferon-gamma production and early synthesis of interleukin-2 by CD4+ CDw29- CD45R- p80- human T lymphocytes.

G. Hedlund, M. Dohlsten, R. Carlsson, 1989, Immunology.

Two subsets of human CD4+T helper cells differing in kinetics and capacities to produce interleukin 2 and interferon‐γ can be defined by the Leu‐18 and UCHLl monoclonal antibodies

G. Hedlund, M. Dohlsten, R. Carlsson, 1988, European journal of immunology.

Rapid response to Con A by CD4+CD45R- rat memory lymphocytes as compared to CD4+CD45R+ lymphocytes.

G. Hedlund, M. Dohlsten, P. Ericsson, 1989, Cellular immunology.

Abrogation of Staphylococcal Enterotoxin A‐Induced Suppressor Cell Activity by the Anti‐Tac Monoclonal Antibody

G. Hedlund, R. Carlsson, H. Sjögren, 1987, Scandinavian journal of immunology.

Immunological abnormalities in a child with constitutional aplastic anemia.

G. Hedlund, S. Garwicz, M. Dohlsten, 1986, Pediatric hematology and oncology.

Lymphocyte subpopulations and lymphokine production in children with constitutional aplastic anemia.

G. Hedlund, S. Garwicz, M. Dohlsten, 1988, Pediatric hematology and oncology.

Catalase and Lipopolysaccharide Enhance Proliferation in the Rat Mixed Lymphocyte Reaction

G. Hedlund, M. Dohlsten, Å. Boketoft, 1987, Scandinavian journal of immunology.

In vivo induction of γ/δ T cells with highly potent and selective anti‐tumor cytotoxicity

J. Hansson, B. Widegren, G. Hedlund, 1991 .

Overexpression of p65 and c-Jun substitutes for B7-1 costimulation by targeting the CD28RE within the IL-2 promoter.

E. Parra, G. Hedlund, M. Dohlsten, 1998, Journal of immunology.

Prevention of superantigen‐induced down‐regulation of T‐cell mediated cytotoxic activity by IL‐2 in vivo

T. Kalland, G. Hedlund, M. Dohlsten, 1997, Immunology.

Superantigens anergize cytokine production but not cytotoxicity in vivo.

M. Björklund, T. Kalland, G. Hedlund, 1994, Immunology.

Staphylococcal-enterotoxin-dependent cell-mediated cytotoxicity.

T. Kalland, G. Hedlund, M. Dohlsten, 1991, Immunology today.

Fusion of a signal sequence to the interleukin-1 beta gene directs the protein from cytoplasmic accumulation to extracellular release.

U. Andersson, U. Gullberg, B. Widegren, 1996, Cellular immunology.

The role of B7-1 and LFA-3 in costimulation of CD8+ T cells.

E. Parra, T. Kalland, G. Hedlund, 1997, Journal of immunology.

Analysis of the murine lymphokine-activated killer (LAK) cell phenomenon: dissection of effectors and progenitors into NK- and T-like cells.

T. Kalland, G. Hedlund, P. Bhiladvala, 1987, Journal of immunology.

Enhanced and prolonged efficacy of superantigen-induced cytotoxic T lymphocyte activity by interleukin-2 in vivo

T. Kalland, G. Hedlund, M. Dohlsten, 1995, Cancer Immunology, Immunotherapy.

Proliferation and differentiation of alloselective NK cells after alloimmunization-evidence for an adaptive NK response.

G. Hedlund, E. Petersson, 1999, Cellular immunology.

Synthesis and biological evaluation of new 1,2-dihydro-4-hydroxy-2-oxo-3-quinolinecarboxamides for treatment of autoimmune disorders: structure-activity relationship.

G. Hedlund, L. Abramo, T. Fex, 2004, Journal of medicinal chemistry.

Linomide abolishes leukocyte adhesion and extravascular recruitment induced by tumor necrosis factor α in vivo

G. Hedlund, H. Thorlacius, P. Borgström, 2000, Journal of leukocyte biology.

Comparison of immune responses induced by rat RT-1 antigens presented as inserts into liposomes, as protein micelles and as intact cells.

G. Hedlund, B. Jansson, H. Sjögren, 1984, Immunology.

Use of a monoclonal rat anti-mouse Ig light chain (RAMOL-1) antibody reduces background binding in immunohistochemical and fluorescent antibody analysis.

G. Hedlund, B. Jansson, N. T. Brodin, 1989, The journal of histochemistry and cytochemistry : official journal of the Histochemistry Society.

and Fluorescent Antibody Analysis

G. Hedlund, N. T. Brodin, Sjøgren, 1989 .

Costimulation of human CD4+ T cells with LFA-3 and B7 induce distinct effects on AP-1 and NF-kappa B transcription factors.

M. Sigvardsson, T. Leanderson, E. Parra, 1995, Journal of immunology.

A phase II study of a 5T4 oncofoetal antigen tumour-targeted superantigen (ABR-214936) therapy in patients with advanced renal cell carcinoma

G. Hedlund, R. Hawkins, J. Zweit, 2007, British Journal of Cancer.

A phase II study of a 5 T 4 oncofoetal antigen tumour-targeted superantigen ( ABR-214936 ) therapy in patients with advanced renal cell carcinoma

G. Hedlund, J. Zweit, P. Stern, 2007 .

1099 A phase II study of ABR-214936 (anatumomab mafenatox) tumour targeted superantigen (TTS) therapy in patients with advanced renal cell carcinoma (RCC)

P. Stern, C. Garner, P. Patel, 2003 .

Interleukin‐10 mediates the protective effect of Linomide by reducing CXC chemokine production in endotoxin‐induced liver injury

G. Hedlund, B. Jeppsson, H. Thorlacius, 2004, British journal of pharmacology.

Protective effect of Linomide on TNF-α-induced hepatic injury

G. Hedlund, H. Thorlacius, D. Klintman, 2002 .

Evidence for the Existence of W3/13+ Monocytes in the Rat

G. Hedlund, B. Jansson, S. Segrén, 1986, Scandinavian journal of immunology.

In vivo induction of gamma/delta T cells with highly potent and selective anti-tumor cytotoxicity.

J. Hansson, B. Widegren, G. Hedlund, 1991, European Journal of Immunology.

Induction of transplantation immunity to rat colon carcinoma isografts by implantation of intact fetal colon tissue

G. Hedlund, H. O. Sjögren, H. Sjögren, 1980, International journal of cancer.

T Cell Activation Pathways: B7, LFA-3, and ICAM-1 Shape Unique T Cell Profiles.

E. Parra, T. Kalland, G. Hedlund, 2017, Critical reviews in immunology.

Allogeneic heart transplantation activates alloreactive NK cells.

J. Hansson, G. Hedlund, M. Dohlsten, 1997, Cellular immunology.

Independent regulation of IFN-gamma and tumor necrosis factor by IL-1 in human T helper cells.

T. Kalland, G. Hedlund, M. Dohlsten, 1990, Journal of immunology.

Linomide and Antibody-Targeted Superantigen Therapy Abolishes Formation of Liver Metastases in Mice

G. Hedlund, M. Corbascio, H. Ekberg, 2003, European Surgical Research.

The Tumor Targeted Superantigen ABR-217620 Selectively Engages TRBV7-9 and Exploits TCR-pMHC Affinity Mimicry in Mediating T Cell Cytotoxicity

B. Jakobsen, G. Hedlund, K. Lindkvist-Petersson, 2013, PloS one.

A novel co-stimulatory T cell antigen co-expressed on renal cell carcinoma.

R. Vessella, T. Kalland, G. Hedlund, 1995, International immunology.

Monotherapeutically Nonactive CTLA-4 Blockade Results in Greatly Enhanced Antitumor Effects When Combined With Tumor-targeted Superantigens in a B16 Melanoma Model

G. Hedlund, A. Sundstedt, M. Törngren, 2012, Journal of immunotherapy.

Tumor-targeted superantigens produce curative tumor immunity with induction of memory and demonstrated antigen spreading

G. Hedlund, M. Törngren, A. Friedmann, 2023, Journal of Translational Medicine.

Activation and selection of NK cells via recognition of an allogeneic, non‐classical MHC class I molecule, RT1‐E

R. Holmdahl, G. Hedlund, G. Butcher, 1999, European journal of immunology.

In vivo induced allo-reactive natural killer cells.

J. Hansson, G. Hedlund, M. Dohlsten, 1992, Journal of immunology.

Selective induction of OX19+ (CD5+) or OX19- (CD5-) alloreactive cytolytic lymphocytes in the rat.

G. Hedlund, T. Brodin, H. Sjögren, 1987, Cellular immunology.

Naptumomab Estafenatox: Targeted Immunotherapy with a Novel Immunotoxin

G. Hedlund, R. Hawkins, T. Eisen, 2014, Current Oncology Reports.

A Randomized Phase II/III Study of Naptumomab Estafenatox + IFNα versus IFNα in Renal Cell Carcinoma: Final Analysis with Baseline Biomarker Subgroup and Trend Analysis

M. Gore, G. Hedlund, R. Hawkins, 2016, Clinical Cancer Research.

A randomized phase II/III study of naptumomab estafenatox plus IFN-α versus IFN-α in advanced renal cell carcinoma.

M. Gore, G. Hedlund, R. Hawkins, 2013 .