T. Muchamuel

发表

Interleukin 10 protects mice from lethal endotoxemia

M. Howard, S. Menon, T. Muchamuel, 1993, The Journal of experimental medicine.

Ocular Inflammation Chemokines in Th1- Versus Th2-Mediated Differential Induction of Cytokines and Inflammatory Mediators in Uveitis:

E. Wawrousek, I. Gery, T. Muchamuel, 2002 .

Inflammatory Mediators in Uveitis: Differential Induction of Cytokines and Chemokines in Th1- Versus Th2-Mediated Ocular Inflammation

E. Wawrousek, I. Gery, T. Muchamuel, 2002, The Journal of Immunology.

Design and synthesis of an orally bioavailable and selective peptide epoxyketone proteasome inhibitor (PR-047).

S. Demo, M. Aujay, T. Muchamuel, 2009, Journal of medicinal chemistry.

Inhibition of the immunoproteasome ameliorates experimental autoimmune encephalomyelitis

T. Muchamuel, M. Groettrup, C. Kirk, 2014, EMBO molecular medicine.

Beneficial effect of novel proteasome inhibitors in murine lupus via dual inhibition of type I interferon and autoantibody-secreting cells.

T. Muchamuel, T. Conley, J. Anolik, 2012, Arthritis and rheumatism.

Signal peptide mimicry primes Sec61 for client-selective inhibition

J. Taunton, C. Kalyanaraman, J. Huiskonen, 2022, bioRxiv.

Non-viral delivery of nuclear factor-κB decoy ameliorates murine inflammatory bowel disease and restores tissue homeostasis

L. Komuves, B. Schryver, T. Muchamuel, 2006, Gut.

IL-25 induces IL-4, IL-5, and IL-13 and Th2-associated pathologies in vivo.

M. Leach, S. Menon, D. Rennick, 2001, Immunity.

Cytokine Networking in Lungs of Immunocompetent Mice in Response to Inhaled Aspergillus fumigatus

J. Brieland, Craig Jackson, D. Loebenberg, 2001, Infection and Immunity.

David Aspergillus fumigatus Inhaled Immunocompetent Mice in Response to Cytokine Networking in Lungs of

R. Kastelein, J. Brieland, Craig Jackson, 2000 .

New IL-17 Family Members Promote Th1 or Th2 Responses in the Lung: In Vivo Function of the Novel Cytokine IL-251

R. Coffman, J. Brieland, Craig Jackson, 2002, The Journal of Immunology.

Modulation of Inhaled Antigen-Induced IgE Tolerance by Ongoing Th2 Responses in the Lung1

R. Coffman, V. Kurup, T. Muchamuel, 2001, The Journal of Immunology.

Lung Tolerance by Ongoing Th2 Responses in the Modulation of Inhaled Antigen-Induced IgE

R. Coffman, V. Kurup, T. Muchamuel, 2001 .

Blockade of experimental atopic dermatitis via topical NF-kappaB decoy oligonucleotide.

L. Komuves, B. Schryver, T. Muchamuel, 2006, The Journal of investigative dermatology.

Immunomodulatory Role of Endogenous Interleukin-18 in Gamma Interferon-Mediated Resolution of Replicative Legionella pneumophila Lung Infection

J. Brieland, Craig Jackson, D. Loebenberg, 2000, Infection and Immunity.

IL-13 protects mice from lipopolysaccharide-induced lethal endotoxemia: correlation with down-modulation of TNF-alpha, IFN-gamma, and IL-12 production.

D. Cockayne, M. Howard, S. Menon, 1997, Journal of immunology.

The Selective Proteasome Inhibitor Carfilzomib Is Well Tolerated in Experimental Animals with Dose Intensive Administration

M. Aujay, T. Muchamuel, M. Bennett, 2008 .

Continuous administration of anti-interleukin 10 antibodies delays onset of autoimmunity in NZB/W F1 mice

M. Howard, H. Ishida, S. Menon, 1994, The Journal of experimental medicine.

Mice deficient for the ecto-nicotinamide adenine dinucleotide glycohydrolase CD38 exhibit altered humoral immune responses.

D. Cockayne, M. Howard, T. Muchamuel, 1998, Blood.

Nonproteasomal Targets of the Proteasome Inhibitors Bortezomib and Carfilzomib: a Link to Clinical Adverse Events

T. Muchamuel, M. Bennett, F. Parlati, 2011, Clinical Cancer Research.

A selective inhibitor of the immunoproteasome subunit LMP7 blocks cytokine production and attenuates progression of experimental arthritis

Khalid W. Kalim, S. Demo, E. Suzuki, 2009, Nature Medicine.

Mice Deficient for the Ecto-Nicotinamide Adenine Dinucleotide Glycohydrolase CD38 Exhibit Altered Humoral Immune Responses

D. Cockayne, M. Howard, T. Muchamuel, 1998 .

Role of Epoxide Hydrolases and Cytochrome P450s on Metabolism of KZR-616, a First-in-Class Selective Inhibitor of the Immunoproteasome

B. Hammock, C. Morisseau, T. Muchamuel, 2021, Drug Metabolism and Disposition.

Zetomipzomib (KZR-616) attenuates lupus in mice via modulation of innate and adaptive immune responses

B. Tuch, T. Muchamuel, E. Lowe, 2023, Frontiers in Immunology.

Discovery and Early Clinical Development of Selective Immunoproteasome Inhibitors

T. Muchamuel, R. A. Fan, C. Kirk, 2021, Cells.

Required Immunoproteasome Subunit Inhibition Profile for Anti-Inflammatory Efficacy and Clinical Candidate KZR-616 ((2 S,3 R)- N-(( S)-3-(Cyclopent-1-en-1-yl)-1-(( R)-2-methyloxiran-2-yl)-1-oxopropan-2-yl)-3-hydroxy-3-(4-methoxyphenyl)-2-(( S)-2-(2-morpholinoacetamido)propanamido)propenamide).

T. Muchamuel, E. Lowe, C. Kirk, 2018, Journal of medicinal chemistry.

Discovery of Highly Selective Inhibitors of the Immunoproteasome Low Molecular Mass Polypeptide 2 (LMP2) Subunit.

E. Bradley, T. Muchamuel, E. Lowe, 2017, ACS medicinal chemistry letters.

Abstract 2607: The benefits of irreversibility: Infusion administration of carfilzomib results in potent proteasome inhibition and improved safety in animals

T. Muchamuel, C. Kirk, Susan Lee, 2011 .

Beneficial effect of novel proteasome inhibitors in murine lupus via dual inhibition of type I interferon and autoantibody-secreting cells.

T. Muchamuel, T. Conley, J. Anolik, 2012, Arthritis & Rheumatism.