C. Zoja

A. Benigni, C. Zoja, C. Zanchi, 2015, Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association.

Cyclosporin-induced endothelial cell injury.

G. Remuzzi, A. Benigni, C. Zoja, 1986, Laboratory investigation; a journal of technical methods and pathology.

Colchicine interferes with L-selectin and leukocyte function-associated antigen-1 expression on human T lymphocytes and inhibits T cell activation.

N. Perico, G. Remuzzi, M. Sayegh, 1996, Journal of the American Society of Nephrology : JASN.

Proteasomal processing of albumin by renal dendritic cells generates antigenic peptides.

G. Remuzzi, A. Benigni, R. Fanelli, 2009, Journal of the American Society of Nephrology : JASN.

Effect of short-term cyclosporine administration in rats on renin-angiotensin and thromboxane A2: possible relevance to the reduction in glomerular filtration rate.

N. Perico, G. Remuzzi, A. Benigni, 1986, The Journal of pharmacology and experimental therapeutics.

A preclinical overview of emerging therapeutic targets for glomerular diseases

G. Remuzzi, C. Zoja, Luca Perico, 2019, Expert opinion on therapeutic targets.

17β-Estradiol corrects hemostasis in uremic rats by limiting vascular expression of nitric oxide synthases

G. Remuzzi, F. Gaspari, M. Noris, 2000 .

17 b -Estradiol corrects hemostasis in uremic rats by limiting vascular expression of nitric oxide synthases

G. Remuzzi, F. Gaspari, M. Noris, 2000 .

Renal expression of monocyte chemoattractant protein-1 in lupus autoimmune mice.

B. Rollins, G. Remuzzi, G. Taraboletti, 1997, Journal of the American Society of Nephrology : JASN.

Effect of ACE inhibition on glomerular permselectivity and tubular albumin concentration in the renal ablation model.

G. Remuzzi, A. Remuzzi, F. Gaspari, 2011, American journal of physiology. Renal physiology.

Combining lisinopril and l-arginine slows disease progression and reduces endothelin-1 in passive Heymann nephritis.

G. Remuzzi, A. Benigni, M. Todeschini, 2003, Kidney international.

Endothelin and eicosanoid synthesis in cultured mesangial cells.

N. Perico, G. Remuzzi, A. Benigni, 1990, Kidney international.

Role of platelets in progressive glomerular diseases

G. Remuzzi, C. Zoja, 1995, Pediatric Nephrology.

Time course and localization of endothelin-1 gene expression in a model of renal disease progression.

G. Remuzzi, E. Schiffrin, A. Benigni, 1997, American Journal of Pathology.

Sequence of glomerular changes in experimental endotoxemia: a possible model of hemolytic uremic syndrome.

G. Remuzzi, M. Abbate, C. Zoja, 1989, Nephron.

Microvascular Thrombosis Exuberant C3a Formation That Triggers Complement by Shiga Toxin Promotes Alternative Pathway Activation of

G. Remuzzi, M. Gobbi, M. Morigi, 2011 .

Tissue plasminogen activator therapy of rabbit nephrotoxic nephritis.

G. Remuzzi, C. Zoja, T. Bertani, 1990, Laboratory investigation; a journal of technical methods and pathology.

FK 506 does not affect the glomerular filtration rate and renal plasma flow in the rat.

N. Perico, G. Remuzzi, A. Benigni, 1991, Transplantation proceedings.

Plasmatic regulation of vascular prostacyclin in pregnancy.

G. Remuzzi, G. de Gaetano, C. Zoja, 1981, British medical journal.

Verotoxin glycolipid receptors determine the localization of microangiopathic process in rabbits given verotoxin-1.

G. Remuzzi, M. Abbate, C. Lingwood, 1992, The Journal of laboratory and clinical medicine.

Low Nephron Number Induced by Maternal Protein Restriction Is Prevented by Nicotinamide Riboside Supplementation Depending on Sirtuin 3 Activation

G. Remuzzi, A. Benigni, B. Imberti, 2022, Cells.

Add-On Cyclic Angiotensin-(1-7) with Cyclophosphamide Arrests Progressive Kidney Disease in Rats with ANCA Associated Glomerulonephritis

G. Remuzzi, A. Benigni, M. Abbate, 2022, Cells.

Passive Heymann nephritis: evidence that angiotensin-converting enzyme inhibition reduces proteinuria and retards renal structural injury.

G. Remuzzi, A. Benigni, C. Zoja, 1996, Experimental nephrology.

TimeCourseandLocalization ofEndothelin-1 Gene Expression ina ModelofRenalDisease Progression

G. Remuzzi, A. Benigni, S. Orisio, 1997 .

Selective inhibition of platelet thromboxane generation with low-dose aspirin does not protect rats with reduced renal mass from the development of progressive disease.

G. Remuzzi, A. Benigni, M. Abbate, 1989, The American journal of pathology.

Altered Renovascular Endothelial Functions During Nephrotoxicity

N. Perico, G. Remuzzi, C. Zoja, 1991 .

Unrecognized pattern of von Willebrand factor abnormalities in hemolytic uremic syndrome and thrombotic thrombocytopenic purpura.

G. Remuzzi, A. Benigni, P. Ruggenenti, 1999, Journal of the American Society of Nephrology : JASN.

Angiotensin II Blockade Limits Tubular Protein Overreabsorption and the Consequent Upregulation of Endothelin 1 Gene in Experimental Membranous Nephropathy

G. Remuzzi, E. Schiffrin, A. Benigni, 1998, Nephron Experimental Nephrology.

Rosuvastatin treatment prevents progressive kidney inflammation and fibrosis in stroke-prone rats.

G. Remuzzi, E. Tremoli, M. Abbate, 2007, The American journal of pathology.

Interleukin-1β and tumor necrosis factor-α induce gene expression and production of leukocyte chemotactic factors, colony-stimulating factors, and interleukin-6 in human mesangial cells

G. Remuzzi, A. Mantovani, Ji Ming Wang, 1991 .

Interleukin-1 regulates cytokine gene expression in human mesangial cells through the interleukin-1 receptor type 1.

G. Remuzzi, M. Morigi, C. Zoja, 1992, Journal of the American Society of Nephrology : JASN.

Alteration of thyroid hormone signaling triggers the diabetes-induced pathological growth, remodeling, and dedifferentiation of podocytes.

A. M. Lavecchia, G. Remuzzi, A. Benigni, 2019, JCI insight.

Leukocyte-endothelial interaction is augmented by high glucose concentrations and hyperglycemia in a NF-kB-dependent fashion.

G. Remuzzi, A. Remuzzi, B. Imberti, 1998, The Journal of clinical investigation.

Shiga Toxin 2 Triggers C3a-Dependent Glomerular and Tubular Injury through Mitochondrial Dysfunction in Hemolytic Uremic Syndrome

G. Remuzzi, A. Benigni, B. Imberti, 2022, Cells.

Transforming Growth Factor-β1 Is Up-Regulated by Podocytes in Response to Excess Intraglomerular Passage of Proteins: A Central Pathway in Progressive Glomerulosclerosis

G. Remuzzi, M. Abbate, M. Morigi, 2002 .

Partial isolation and function of the prostacyclin regulating plasma factor.

A. Todisco, C. Zoja, P. Gresele, 1985, Clinical science.

THE ACUTE EFFECT OF FK506 AND CYCLOSPORINE ON ENDOTHELIAL CELL FUNCTION AND RENAL VASCULAR RESISTANCE

N. Perico, G. Remuzzi, A. Benigni, 1992, Transplantation.

Oral zeranol shortens the prolonged bleeding time of uremic rats.

S. Garattini, C. Zoja, G. Remuzzi, 1990, Kidney international.

Prostacyclin in thrombotic microangiopathy.

G. Remuzzi, C. Zoja, E. Rossi, 1987, Seminars in hematology.

Simplified Method to Measure Glomerular Filtration Rate by Iohexol Plasma Clearance in Conscious Rats

F. Gaspari, E. Porrini, Fabiola Carrara, 2016, Nephron.

Role of renal prostaglandins in normal and nephrotic rats with diet-induced hyperfiltration.

G. Remuzzi, A. Remuzzi, A. Benigni, 1986, The Journal of laboratory and clinical medicine.

Contents Vol. 27, 2007

J. McGill, W. Bolton, N. Perico, 2007, American Journal of Nephrology.

Renal Primordia Activate Kidney Regenerative Events in a Rat Model of Progressive Renal Disease

G. Remuzzi, A. Benigni, B. Imberti, 2015, PloS one.

Angiotensin-converting enzyme inhibition prevents loss of glomerular hydraulic permeability in passive heymann nephritis.

G. Remuzzi, A. Remuzzi, C. Zoja, 1999, Laboratory investigation; a journal of technical methods and pathology.

Glomerular size selectivity in nephrotic rats exposed to diets with different protein content.

G. Remuzzi, A. Remuzzi, C. Zoja, 1987, The American journal of physiology.

L-arginine, the precursor of nitric oxide, abolishes the effect of estrogens on bleeding time in experimental uremia.

N. Perico, G. Remuzzi, G. de Gaetano, 1991, Laboratory investigation; a journal of technical methods and pathology.

17 beta-estradiol is the most active component of the conjugated estrogen mixture active on uremic bleeding by a receptor mechanism.

S. Garattini, C. Zoja, M. Rossini, 1990, The Journal of pharmacology and experimental therapeutics.

Prolonged bleeding time and increased vascular prostacyclin in rats with chronic renal failure: effects of conjugated estrogens.

A. Benigni, G. de Gaetano, C. Zoja, 1988, The Journal of laboratory and clinical medicine.

Prostacyclin and Hemolytic Uremic Syndrome: From the Laboratory to An International Registry

G. Remuzzi, G. de Gaetano, C. Zoja, 1987, The International journal of artificial organs.

ADAMTS13 Deficiency Shortens the Life Span of Mice With Experimental Diabetes

G. Remuzzi, A. Benigni, G. Taraboletti, 2018, Diabetes.

Cyclosporine enhances leukocyte adhesion to vascular endothelium under physiologic flow conditions.

G. Remuzzi, A. Remuzzi, B. Imberti, 1996, American journal of kidney diseases : the official journal of the National Kidney Foundation.

Low-protein diet prevents glomerular damage in adriamycin-treated rats.

G. Remuzzi, A. Remuzzi, M. Broggini, 1985, Kidney international.

Complement-mediated dysfunction of glomerular filtration barrier accelerates progressive renal injury.

G. Remuzzi, M. Abbate, M. Morigi, 2008, Journal of the American Society of Nephrology : JASN.

Unique pattern of expression and inhibition of IL-1 signaling by the IL-1 receptor family member TIR8/SIGIRR.

C. Garlanda, A. Mantovani, A. Benigni, 2003, European cytokine network.

Angiotensin II contributes to diabetic renal dysfunction in rodents and humans via Notch1/Snail pathway.

N. Perico, G. Remuzzi, A. Benigni, 2013, The American journal of pathology.

Dipyridamole Inhibits Platelet Aggregation in Whole Blood

C. Zoja, M. Verstraete, P. Gresele, 1983, Thrombosis and Haemostasis.

A previously unrecognized role of C3a in proteinuric progressive nephropathy

G. Remuzzi, A. Benigni, C. Rota, 2016, Scientific Reports.

Mesenchymal stem cell therapy promotes renal repair by limiting glomerular podocyte and progenitor cell dysfunction in adriamycin-induced nephropathy.

Sara Conti, Giuseppe Remuzzi, Paolo Bigini, 2012, American journal of physiology. Renal physiology.

Protein Overload Activates Proximal Tubular Cells to Release Vasoactive and Inflammatory Mediators

G. Remuzzi, A. Benigni, C. Zoja, 1999, Nephron Experimental Nephrology.

Complement Activation Contributes to the Pathophysiology of Shiga Toxin-Associated Hemolytic Uremic Syndrome

G. Remuzzi, M. Morigi, C. Zoja, 2019, Microorganisms.

Shiga toxin triggers endothelial and podocyte injury: the role of complement activation

M. Morigi, C. Zoja, Simona Buelli, 2019, Pediatric Nephrology.

Lack of the Lectin-like Domain of Thrombomodulin Worsens Shiga Toxin-Associated Hemolytic Uremic Syndrome in Mice

G. Remuzzi, B. Isermann, M. Noris, 2012, The Journal of Immunology.

Protein overload stimulates RANTES production by proximal tubular cells depending on NF-kappa B activation.

G. Remuzzi, M. Morigi, M. Figliuzzi, 1998, Kidney international.

Proximal tubular cell synthesis and secretion of endothelin-1 on challenge with albumin and other proteins.

G. Remuzzi, A. Benigni, M. Morigi, 1995, American journal of kidney diseases : the official journal of the National Kidney Foundation.

Progression of renal injury toward interstitial inflammation and glomerular sclerosis is dependent on abnormal protein filtration.

G. Remuzzi, M. Abbate, C. Zoja, 2015, Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association.

Alternative Pathway Activation of Complement by Shiga Toxin Promotes Exuberant C3a Formation That Triggers Microvascular Thrombosis

G. Remuzzi, M. Gobbi, M. Morigi, 2011, The Journal of Immunology.

Thrombospondin induces glomerular mesangial cell adhesion and migration.

G. Remuzzi, G. Taraboletti, R. Giavazzi, 1992, Laboratory investigation; a journal of technical methods and pathology.

In response to protein load podocytes reorganize cytoskeleton and modulate endothelin-1 gene: implication for permselective dysfunction of chronic nephropathies.

G. Remuzzi, A. Benigni, M. Morigi, 2005, The American journal of pathology.

Transforming Growth Factor- (cid:1) 1 Is Up-Regulated by Podocytes in Response to Excess Intraglomerular Passage of Proteins A Central Pathway in Progressive Glomerulosclerosis

G. Remuzzi, M. Abbate, M. Morigi, 2022 .

Xenogeneic serum promotes leukocyte-endothelium interaction under flow through two temporally distinct pathways: role of complement and nuclear factor-kappaB.

G. Remuzzi, A. Remuzzi, B. Imberti, 1999, Journal of the American Society of Nephrology : JASN.

Disruption of the Ang II type 1 receptor promotes longevity in mice.

G. Remuzzi, A. Benigni, R. Latini, 2009, The Journal of clinical investigation.

How does proteinuria cause progressive renal damage?

G. Remuzzi, M. Abbate, C. Zoja, 2006, Journal of the American Society of Nephrology : JASN.

Shiga toxin promotes podocyte injury in experimental hemolytic uremic syndrome via activation of the alternative pathway of complement.

G. Remuzzi, J. Thurman, M. Morigi, 2014, Journal of the American Society of Nephrology : JASN.

Chapter 87 – Role of Proteinuria in the Progression of Renal Disease

G. Remuzzi, M. Abbate, C. Zoja, 2013 .

Verotoxin-1 promotes leukocyte adhesion to cultured endothelial cells under physiologic flow conditions.

G. Remuzzi, A. Remuzzi, B. Imberti, 1995, Blood.

Beneficial Effect of TGFβ Antagonism in Treating Diabetic Nephropathy Depends on When Treatment Is Started

G. Remuzzi, A. Benigni, E. Gagliardini, 2006, Nephron Experimental Nephrology.

Verotoxin-1-induced up-regulation of adhesive molecules renders microvascular endothelial cells thrombogenic at high shear stress.

G. Remuzzi, A. Remuzzi, B. Imberti, 2001, Blood.

Coichicine Interferes with L-Selectin and Leukocyte Function-Associated Antigen-i Expression on Human I Lymphocytes a nd Inhibits I Cell

N. Perico, G. Remuzzi, M. Sayegh, 1996 .

Supernatant of endothelial cells exposed to laminar flow inhibits mesangial cell proliferation.

G. Remuzzi, A. Remuzzi, M. Morigi, 1993, American Journal of Physiology.

Renoprotection by nitric oxide donor and lisinopril in the remnant kidney model.

G. Remuzzi, A. Benigni, M. Noris, 1999, American journal of kidney diseases : the official journal of the National Kidney Foundation.

Mycophenolate mofetil limits renal damage and prolongs life in murine lupus autoimmune disease.

G. Remuzzi, M. Morigi, C. Zoja, 1997, Kidney international.

Adding a statin to a combination of ACE inhibitor and ARB normalizes proteinuria in experimental diabetes, which translates into full renoprotection.

G. Remuzzi, A. Benigni, E. Gagliardini, 2010, American journal of physiology. Renal physiology.

The Nrf2 pathway in the progression of renal disease.

G. Remuzzi, A. Benigni, C. Zoja, 2014, Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association.

Protein Overload-Induced NF-κB Activation in Proximal Tubular Cells Requires H2O2 through a PKC-Dependent Pathway

G. Remuzzi, M. Morigi, C. Zoja, 2002 .

Combining an antiproteinuric approach with mycophenolate mofetil fully suppresses progressive nephropathy of experimental animals.

G. Remuzzi, A. Benigni, E. Gagliardini, 1999, Journal of the American Society of Nephrology : JASN.

Renal protective effect of angiotensin-converting enzyme inhibition in aging rats.

N. Perico, G. Remuzzi, A. Remuzzi, 1992, The American journal of medicine.

CHAPTER 89 – Role of Proteinuria in Progression

G. Remuzzi, M. Abbate, C. Zoja, 2008 .

A study of low-nutrient diets used for aging studies in the rat.

C. Zoja, T. Bertani, D. Corna, 1996, The journals of gerontology. Series A, Biological sciences and medical sciences.

Renal and systemic nitric oxide synthesis in rats with renal mass reduction.

G. Remuzzi, A. Benigni, M. Noris, 1997, Kidney international.

Genetics of rare diseases of the kidney: learning from mouse models

G. Remuzzi, A. Benigni, M. Morigi, 2004, Cytogenetic and Genome Research.

C3a receptor blockade protects podocytes from injury in diabetic nephropathy.

G. Remuzzi, A. Benigni, M. Morigi, 2020, JCI insight.

Cellular responses to protein overload: key event in renal disease progression

G. Remuzzi, A. Benigni, C. Zoja, 2004, Current opinion in nephrology and hypertension.

Thromboxane synthesis inhibition increases renal prostacyclin and prevents renal disease progression in rats with remnant kidney.

N. Perico, G. Remuzzi, A. Benigni, 1990, Journal of the American Society of Nephrology : JASN.

Transcriptional regulation of nephrin gene by peroxisome proliferator-activated receptor-gamma agonist: molecular mechanism of the antiproteinuric effect of pioglitazone.

G. Remuzzi, A. Benigni, E. Gagliardini, 2006, Journal of the American Society of Nephrology : JASN.

Proteinuria and phenotypic change of proximal tubular cells.

G. Remuzzi, M. Morigi, C. Zoja, 2003, Journal of the American Society of Nephrology : JASN.

Analogs of bardoxolone methyl worsen diabetic nephropathy in rats with additional adverse effects.

G. Remuzzi, A. Benigni, F. Gaspari, 2013, American journal of physiology. Renal physiology.

Interleukin-1 beta and tumor necrosis factor-alpha induce gene expression and production of leukocyte chemotactic factors, colony-stimulating factors, and interleukin-6 in human mesangial cells.

G. Remuzzi, A. Mantovani, H. Abboud, 1991, American Journal of Pathology.

Protein load impairs factor H binding promoting complement-dependent dysfunction of proximal tubular cells.

G. Remuzzi, P. Zipfel, M. Abbate, 2009, Kidney international.

The Nrf 2 pathway in the progression of renal disease

G. Remuzzi, A. Benigni, C. Zoja, 2014 .

Antiplatelet agents: effects on the progressive renal disease.

N. Perico, G. Remuzzi, C. Zoja, 1991, American journal of kidney diseases : the official journal of the National Kidney Foundation.

Vasopeptidase inhibitor restores the balance of vasoactive hormones in progressive nephropathy.

G. Remuzzi, A. Benigni, M. Noris, 2004, Kidney international.

Manipulating Sirtuin 3 pathway ameliorates renal damage in experimental diabetes

G. Remuzzi, A. Benigni, C. Zoja, 2020, Scientific Reports.

Et and diabetic nephropathy: preclinical and clinical studies.

A. Benigni, E. Gagliardini, C. Zoja, 2015, Seminars in nephrology.

Erratum: Proximal tubular cells promote fibrogenesis by TGF-β1-mediated induction of peritubular myofibroblasts (Kidney International (2002) 6 (2066-2077))

G. Remuzzi, M. Abbate, C. Zoja, 2002 .

Reduced fibrinolytic activity in glomeruli isolated from rabbits infused with tumor necrosis factor.

G. Remuzzi, C. Zoja, N. Semeraro, 1993, Haemostasis.

Shigatoxin-induced endothelin-1 expression in cultured podocytes autocrinally mediates actin remodeling.

G. Remuzzi, A. Benigni, M. Morigi, 2006, The American journal of pathology.

The prostacyclin stimulating plasma factor (pspf) protects endothelial-cells from exhaustion

A. Todisco, C. Zoja, H. Deckmyn, 1983 .

Proinflammatory mediators of glomerular injury and mechanisms of activation of autoreactive T cells.

N. Perico, G. Remuzzi, C. Zoja, 1994, Kidney international. Supplement.

Lack of synergism between dazoxiben and dipyridamole following administration to man.

C. Zoja, P. Gresele, H. Deckmyn, 1985, Thrombosis research.

Renin-angiotensin system and glomerular prostaglandins in early nephrotoxicity of ciclosporin.

N. Perico, G. Remuzzi, A. Benigni, 1986, Contributions to nephrology.

How to fully protect the kidney in a severe model of progressive nephropathy: a multidrug approach.

G. Remuzzi, M. Abbate, D. Cattaneo, 2002, Journal of the American Society of Nephrology.

Complement-mediated dysfunction of glomerular filtration barrier accelerates progressive renal injury.

G. Remuzzi, M. Abbate, M. Morigi, 2008, Journal of the American Society of Nephrology : JASN.

Targeted deletion of angiotensin II type 1A receptor does not protect mice from progressive nephropathy of overload proteinuria.

N. Perico, G. Remuzzi, A. Benigni, 2004, Journal of the American Society of Nephrology : JASN.

Blocking both type A and B endothelin receptors in the kidney attenuates renal injury and prolongs survival in rats with remnant kidney.

G. Remuzzi, A. Benigni, S. Orisio, 1996, American journal of kidney diseases : the official journal of the National Kidney Foundation.

Liver factor B silencing to cure C3 glomerulopathy: Evidence from a mouse model of complement dysregulation.

G. Remuzzi, A. Benigni, M. Noris, 2023, Molecular immunology.

Unrecognized pattern of von Willebrand factor abnormalities in hemolytic uremic syndrome and thrombotic thrombocytopenic purpura.

G. Remuzzi, A. Benigni, P. Ruggenenti, 1999, Journal of the American Society of Nephrology : JASN.

Thyroid hormone treatment counteracts cellular phenotypical remodeling in diabetic organs

A. M. Lavecchia, C. Xinaris, C. Zoja, 2023, iScience.

The pivotal role of the endothelial cell in the pathogenesis of hus

G. Remuzzi, C. Zoja, 1992 .

Efficacy of GalNAc C3 siRNAs in factor H-deficient mice with C3 glomerulopathy.

A. Benigni, M. Noris, C. Zoja, 2024, Molecular immunology.

In progressive nephropathies, overload of tubular cells with filtered proteins translates glomerular permeability dysfunction into cellular signals of interstitial inflammation.

C. Zoja, D. Corna, Tullio Bertani, 1998, Journal of the American Society of Nephrology : JASN.

Endothelial Glycocalyx of Peritubular Capillaries in Experimental Diabetic Nephropathy: A Target of ACE Inhibitor-Induced Kidney Microvascular Protection

A. Benigni, C. Zoja, D. Macconi, 2023, International journal of molecular sciences.