S. Gerson

P. Fu, S. Gerson, H. Lazarus, 2011, Biology of blood and marrow transplantation : journal of the American Society for Blood and Marrow Transplantation.

High level, regulated expression of the chimeric P-enolpyruvate carboxykinase (GTP)-bacterial O6-alkylguanine-DNA alkyltransferase (ada) gene in transgenic mice.

T. Wagner, S. Gerson, I. Lim, 1990, Cancer research.

Imaging stem cell-derived persistent foci after in vivo selection of lentiviral MGMT-P140K transduced murine bone marrow cells.

David L. Wilson, S. Gerson, Yuan Lin, 2011, Molecular therapy : the journal of the American Society of Gene Therapy.

Future cancer research priorities in the USA: a Lancet Oncology Commission.

Quynh-Thu Le, Martin G Pomper, Levi Garraway, 2017, The Lancet. Oncology.

A Phase II Study of Midostaurin and 5-Azacitidine for Elderly Patients with Acute Myeloid Leukemia

M. Levis, S. Gerson, H. Lazarus, 2017 .

ALKYLTRANSFERASE ACTIVITY IN HEMATOPOIETIC CELLS the changes in alkyltransferase activity in liver , kidney , and bone

S. Gerson, K. Miller, J. Trey, 2006 .

Retroviral-mediated gene transduction of human alkyltransferase complementary DNA confers nitrosourea resistance to human hematopoietic progenitors.

J. Allay, S. Gerson, O. Koç, 1996, Clinical cancer research : an official journal of the American Association for Cancer Research.

Specificity of bischloroethylnitrosourea-induced mutation in a Chinese hamster ovary cell line transformed to express human O6-alkylguanine-DNA alkyltransferase.

M. Veigl, S. Gerson, W. Sedwick, 1993, Cancer research.

Retroviral transduction of a mutant methylguanine DNA methyltransferase gene into human CD34 cells confers resistance to O6-benzylguanine plus 1,3-bis(2-chloroethyl)-1-nitrosourea.

J. Allay, S. Gerson, O. Koç, 1996, Proceedings of the National Academy of Sciences of the United States of America.

Overexpression of human O6-alkylguanine DNA alkyltransferase (AGT) prevents MNU induced lymphomas in heterozygous p53 deficient mice

S. Gerson, E. Allay, J. Reese, 2001, Oncogene.

Human long-term culture initiating cells are sensitive to benzylguanine and 1,3-bis(2-chloroethyl)-1-nitrosourea and protected after mutant (G156A) methylguanine methyltransferase gene transfer

S. Gerson, O. Koç, J. Reese, 1999, Cancer Gene Therapy.

Introduction: genes, oncogenes, and gene therapy strategies for cancer.

S. Gerson, E. Lattime, 1996, Seminars in oncology.

Drug selection of mutant methylguanine methyltransferase from different oncoretroviral backbones results in multilineage hematopoietic transgene expression in primary and secondary recipients.

S. Gerson, J. Reese, B. M. Davis, 2003, Journal of hematotherapy & stem cell research.

Myeloablation is not required to select and maintain expression of the drug-resistance gene, mutant MGMT, in primary and secondary recipients.

S. Gerson, J. Reese, Karen T. Lingas, 2003, Molecular therapy : the journal of the American Society of Gene Therapy.

Selection for G156A O6-methylguanine DNA methyltransferase gene-transduced hematopoietic progenitors and protection from lethality in mice treated with O6-benzylguanine and 1,3-bis(2-chloroethyl)-1-nitrosourea.

S. Gerson, O. Koç, K. Lee, 1997, Cancer research.

Human alkyltransferase-transduced murine myeloid progenitors are enriched in vivo by BCNU treatment of transplanted mice.

J. Allay, S. Gerson, B. M. Davis, 1997, Experimental hematology.

In vitro eradication of neuroblastoma (NB) cells by monoclonal antibody (Mab) and human complement (C'): A method for purging autologous bone marrow (BM)

S. Gerson, P. Coccia, U. Saarinen, 1985 .

BM Hematopoietic Niche Occupancy Defect of HSC in Scid Mice

S. Gerson, Yulan Qing, 2014 .

Lack of correlation between DNA methylation and hepatocarcinogenesis in rats and hamsters treated with 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone.

S. Gerson, A. Castonguay, L. Liu, 1992, Carcinogenesis.

Differential competitive resistance to methylating versus chloroethylating agents among five O6-alkylguanine DNA alkyltransferases in human hematopoietic cells

L. Loeb, M. Zago, D. Covas, 2006, Molecular Cancer Therapeutics.

Simultaneous protection of G156A methylguanine DNA methyltransferase gene-transduced hematopoietic progenitors and sensitization of tumor cells using O6-benzylguanine and temozolomide.

S. Gerson, J. Reese, B. M. Davis, 1999, Clinical cancer research : an official journal of the American Association for Cancer Research.

Reduced lung tumorigenesis in human methylguanine DNA--methyltransferase transgenic mice achieved by expression of transgene within the target cell.

Lili Liu, S. Gerson, X. Qin, 1999, Carcinogenesis.

Randomized cross-over trial of progenitor-cell mobilization: high-dose cyclophosphamide plus granulocyte colony-stimulating factor (G-CSF) versus granulocyte-macrophage colony-stimulating factor plus G-CSF.

L. Kutteh, S. Gerson, H. Lazarus, 2000, Journal of clinical oncology : official journal of the American Society of Clinical Oncology.

Phase I and correlative study of combination bryostatin 1 and vincristine in relapsed B-cell malignancies.

C. Whitacre, J. Jacobberger, A. Murgo, 2003, Clinical cancer research : an official journal of the American Association for Cancer Research.

O6-methylguanine-DNA methyltransferase (MGMT) transfectants of a 1,3-bis(2-chloroethyl)-1-nitrosourea (BCNU)-sensitive colon cancer cell line selectively repopulate heterogenous MGMT+/MGMT- xenografts after BCNU and O6-benzylguanine plus BCNU.

J. Willson, S. Markowitz, S. Gerson, 1997, Cancer Research.

Synergistic efficacy of O6-benzylguanine and 1,3-bis(2-chloroethyl)-1-nitrosourea (BCNU) in a human colon cancer xenograft completely resistant to BCNU alone.

J. Willson, S. Gerson, E. Zborowska, 1993, Biochemical pharmacology.

Clozapine-Induced Agranulocytosis

J. Lieberman, S. Gerson, J. Alvir, 1995 .

N‐desmethylclozapine: a clozapine metabolite that suppresses haemopoiesis

H. Meltzer, S. Gerson, C. Arce, 1994, British journal of haematology.

Production of human factor VIII-FL in 293T cells using the bicistronic MGMT(P140K)-retroviral vector.

D. Covas, S. Gerson, A. Fontes, 2012, Genetics and molecular research : GMR.

A Fluorescent Probe to Measure DNA Damage and Repair

S. Gerson, Yanming Wang, Allison G. Condie, 2015, PloS one.

Measurement of anti-cancer agent methoxyamine in plasma by tandem mass spectrometry with on-line sample extraction.

Lili Liu, Yan Xu, S. Gerson, 2003, Journal of chromatography. B, Analytical technologies in the biomedical and life sciences.

Adult bone marrow stem cells for cell and gene therapies: Implications for greater use

S. Gerson, S. Zielske, C. Ballas, 2002, Journal of cellular biochemistry. Supplement.

Serodiagnosis of invasive aspergillosis in patients with hematologic malignancy: validation of the Aspergillus fumigatus antigen radioimmunoassay.

S. Gerson, G. Talbot, S. Hurwitz, 1987, The Journal of infectious diseases.

Invasive pulmonary aspergillosis and acute leukemia. Limitations in the diagnostic utility of the air crescent sign.

W. Gefter, S. Albelda, S. Gerson, 1985, Radiology.

Chemoselection of allogeneic HSC after murine neonatal transplantation without myeloablation or post-transplant immunosuppression.

S. Gerson, R. Falahati, L. Flebbe-Rehwaldt, 2012, Molecular therapy : the journal of the American Society of Gene Therapy.

Synergistic Actions of Hematopoietic and Mesenchymal Stem/Progenitor Cells in Vascularizing Bioengineered Tissues

J. Mao, S. Gerson, J. Dennis, 2008, PloS one.

Peritransplant use of ultraviolet-B irradiation (UV-B) therapy is detrimental to allogeneic stem cell transplantation outcome.

P. Fu, S. Gerson, H. Lazarus, 2006, Biology of blood and marrow transplantation : journal of the American Society for Blood and Marrow Transplantation.

Hematologic Effects of Linezolid: Summary of Clinical Experience

S. Gerson, S. Kaplan, J. Bruss, 2002, Antimicrobial Agents and Chemotherapy.

Imaging of Mesenchymal Stem Cell Transplant by Bioluminescence and PET

S. Majewski, Z. Lee, S. Gerson, 2007, Journal of Nuclear Medicine.

Neutrophilic eccrine hidradenitis simulating orbital cellulitis.

S. Gerson, D. Bardenstein, M. Zaim, 1994, Archives of ophthalmology.

Concise Reviews: Cancer Stem Cell Targeted Therapies: Toward Clinical Success

S. Gerson, Amar B. Desai, Yan Yan, 2018, Stem cells translational medicine.

Gene Therapy of Cancer , Third Edition

S. Gerson, E. Lattime, 2014 .

Mechanisms of Clozapine-Induced Agranulocytosis

S. Gerson, H. Meltzer, 1992, Drug safety.

Potentiation of lymphomagenesis by methylnitrosourea in mice transgenic for LMO1 is blocked by O6-alkylguanine DNA-alkyltransferase

N. Sedransk, S. Gerson, E. Allay, 1997, Oncogene.

MGMT: its role in cancer aetiology and cancer therapeutics

S. Gerson, 2004, Nature Reviews Cancer.

Evaluation of O6-Benzylguanine−Potentiated Topical Carmustine for Mycosis Fungoides: A Phase 1-2 Clinical Trial

P. Fu, A. Dowlati, S. Gerson, 2017, JAMA dermatology.

Phase I clinical trial of O6-benzylguanine and topical carmustine in the treatment of cutaneous T-cell lymphoma, mycosis fungoides type.

S. K. Szabo, G. Wood, Lili Liu, 2012, Archives of dermatology.

Plasma and cerebrospinal fluid pharmacokinetics of O6-benzylguanine and time course of peripheral blood mononuclear cell O6-methylguanine-DNA methyltransferase inhibition in the nonhuman primate.

F. Balis, S. Gerson, S. Berg, 1995, Cancer research.

Pharmacokinetics of O6‐Benzylguanine (NSC637037) and Its Metabolite, 8‐Oxo‐O6‐Benzylguanine

J. Willson, C. Hoppel, S. Gerson, 2003, Journal of clinical pharmacology.

Leukocyte O6-alkylguanine-DNA alkyltransferase from human donors is uniformly sensitive to O6-benzylguanine.

S. Gerson, J. Schupp, L. Liu, 1999, Clinical cancer research : an official journal of the American Association for Cancer Research.

Leukocyte O 6-Alkylguanine-DNA Alkyltransferase from Human Donors Is Uniformly Sensitive to O 6-Benzylguanine 1

Lili Liu, A. Pegg, S. Gerson, 1999 .

Phase II Trial of the O6-Alkylguanine DNA Alkyltransferase Inhibitor O6-Benzylguanine and 1,3-Bis(2-Chloroethyl)-1-Nitrosourea in Advanced Melanoma

J. Sosman, E. Vokes, Lili Liu, 2005, Clinical Cancer Research.

Acquired resistance to O 6-benzylguanine plus chloroethylnitrosoureas in human breast cancer

S. Gerson, Weldon P. Phillips Jr., 1999, Cancer Chemotherapy and Pharmacology.

DNA repair, ADP-ribosylation and pyridine nucleotide metabolism as targets for cancer chemotherapy.

N. Berger, S. Gerson, S. J. Berger, 1987, Anti-cancer drug design.

O6-benzylguanine and BCNU in multiple myeloma: a phase II trial

Lili Liu, P. Fu, S. Remick, 2007, Cancer Chemotherapy and Pharmacology.

O6-alkylguanine-DNA alkyltransferase. A target for the modulation of drug resistance.

J. Willson, S. Gerson, Stanton L. Gerson, 1995, Hematology/oncology clinics of North America.

The role of O6-alkylguanine DNA alkyltransferase in limiting nitrosourea-induced sister chromatid exchanges in proliferating human lymphocytes.

S. Gerson, J. Trey, 1989, Cancer research.

Simultaneous determination of O6-benzylguanine and 8-oxo-O6-benzylguanine in human plasma by reversed-phase high-performance liquid chromatography.

J. Willson, C. Hoppel, S. Gerson, 1997, Journal of chromatography. B, Biomedical sciences and applications.

Comparison of O6-alkylguanine-DNA alkyltransferase activity based on cellular DNA content in human, rat and mouse tissues.

N. Berger, S. Gerson, K. Miller, 1986, Carcinogenesis.

Determination of O6-benzylguanine in human plasma by reversed-phase high-performance liquid chromatography.

J. Willson, C. Hoppel, S. Gerson, 1996, Journal of chromatography. B, Biomedical applications.

Modulation of nitrosourea resistance in myeloid leukemias.

S. Gerson, J. Trey, Stanton L. Gerson, 1988, Blood.

Comparison of the inactivation of mammalian and bacterial O6-alkylguanine-DNA alkyltransferases by O6-benzylguanine and O6-methylguanine.

M. Dolan, A. Pegg, S. Gerson, 1991, Carcinogenesis.

Rapid repair of O6-methylguanine-DNA adducts protects transgenic mice from N-methylnitrosourea-induced thymic lymphomas.

S. Gerson, E. Allay, L. Liu, 1994, Cancer research.

Combined depletion of O6-alkylguanine-DNA alkyltransferase and glutathione to modulate nitrosourea resistance in breast cancer.

S. Gerson, M. Varnes, S. Berger, 1994, Biochemical pharmacology.

Human CD34+ hematopoietic progenitors have low, cytokine-unresponsive O6-alkylguanine-DNA alkyltransferase and are sensitive to O6-benzylguanine plus BCNU.

M. Kastan, S. Gerson, L. Dumenco, 1996, Blood.

Modulation of nitrosourea resistance in myeloid leukemias

S. Gerson, J. Trey, JE Trey, 1988 .

Clinical Trials Using LV-P140K-MGMT for Gliomas

S. Gerson, Yuan Lin, 2013 .

Cancer gene therapy: scientific basis.

S. Gerson, S. Zielske, C. Ballas, 2002, Annual review of medicine.

Applied molecular evolution of O6-benzylguanine-resistant DNA alkyltransferases in human hematopoietic cells

F. Christians, L. Loeb, Lili Liu, 2001, Proceedings of the National Academy of Sciences of the United States of America.

Characterization of the P140K, PVP(138-140)MLK, and G156A O6-methylguanine-DNA methyltransferase mutants: implications for drug resistance gene therapy.

S. Gerson, M. Xu-Welliver, B. M. Davis, 1999, Human gene therapy.

Differential degradation rates of inactivated alkyltransferase in blood mononuclear cells and tumors of patients after treatment with O(6)-benzylguanine.

J. Haaga, J. Willson, S. Gerson, 2001, Clinical cancer research : an official journal of the American Association for Cancer Research.

Determinants of O6-alkylguanine-DNA alkyltransferase activity in human colon cancer.

S. Gerson, E. Allay, L. Dumenco, 1995, Clinical cancer research : an official journal of the American Association for Cancer Research.

Cotransduction with MGMT and Ubiquitous or Erythroid-Specific GFP Lentiviruses Allows Enrichment of Dual-Positive Hematopoietic Progenitor Cells In Vivo

S. Gerson, G. Ferrari, J. Reese, 2012, ISRN hematology.

Human mesenchymal stem cells provide stromal support for efficient CD34+ transduction.

S. Gerson, O. Koç, J. Reese, 1999, Journal of hematotherapy & stem cell research.

Mice ) Gene in Transgenic ada-Alkylguanine-DNA Alkyltransferase ( 6 O P-Enolpyruvate Carboxykinase ( GTP )-Bacterial High Level , Regulated Expression of the Chimeric

S. Gerson, R. Hanson, D. Clapp, 2006 .

Modulation of 06-Alkylguanine-DNA Alkyltransferase in Rats following Intravenous Administration of 06-Methylguanine'

S. Gerson, Élisabeth, T. Yamashita, 2006 .

Carmustine and streptozocin in refractory melanoma: an attempt at modulation of O-alkylguanine-DNA-alkyltransferase.

R. Day, J. Kirkwood, D. Smith, 1996, Clinical cancer research : an official journal of the American Association for Cancer Research.

Thymidine kinase deficient cells with decreased TTP pools are hypersensitive to DNA alkylating agents.

S. Gerson, K. Furusho, M. Kubota, 1996, Mutation research.

A Clinical Trial Establishing the Biochemical Modulatory Dose in Tumor Tissue for Alkyltransferase-directed DNA Repair 1

J. Haaga, J. Willson, Lili Liu, 1999 .

Uracil DNA glycosylase (UNG) loss enhances DNA double strand break formation in human cancer cells exposed to pemetrexed

P. Scacheri, S. Gerson, G. Zentner, 2014, Cell Death and Disease.

Targets of Small Interfering RNA Restriction during Human Immunodeficiency Virus Type 1 Replication

Yong Gao, Measho H. Abreha, E. Arts, 2008, Journal of Virology.

Germline rearrangements in families with strong family history of glioma and malignant melanoma, colon, and breast cancer

Susan M. Chang, M. Berger, R. Elston, 2014, Neuro-oncology.

Elevated AF1q expression is a poor prognostic marker for adult acute myeloid leukemia patients with normal cytogenetics

W. Tse, S. Gerson, G. Ehninger, 2009, American journal of hematology.

Metabolic regulation by the mitochondrial phosphatase PTPMT1 is required for hematopoietic stem cell differentiation.

H. Broxmeyer, T. Finkel, S. Gerson, 2013, Cell stem cell.

MMTV promoter hypomethylation is linked to spontaneous and MNU associated c-neu expression and mammary carcinogenesis in MMTV c-neu transgenic mice

S. Markowitz, Lili Liu, S. Gerson, 2001, Oncogene.

Mismatch repair deficient hematopoietic stem cells are preleukemic stem cells

S. Gerson, Yulan Qing, 2017, PloS one.

Cancer stem cells: targeting the roots of cancer, seeds of metastasis, and sources of therapy resistance.

G. Kibria, J. Rich, M. Venere, 2015, Cancer research.

Exonuclease 1 is a Critical Mediator of Survival During DNA Double Strand Break Repair in Nonquiescent Hematopoietic Stem and Progenitor Cells

S. Gerson, Amar B. Desai, Yulan Qing, 2014, Stem cells.

Non–lineage/stage-restricted effects of a gain-of-function mutation in tyrosine phosphatase Ptpn11 (Shp2) on malignant transformation of hematopoietic cells

Caiying Guo, S. Gerson, H. Meyerson, 2011, The Journal of experimental medicine.

Pilot trial of intravenous autologous culture-expanded mesenchymal stem cell transplantation in multiple sclerosis

Jeffrey A. Cohen, A. Bar-Or, E. Fisher, 2018, Multiple sclerosis.

Alkylating and Platinating Agents

S. Gerson, 2001 .

Enhanced repair of O6-methylguanine DNA adducts in the liver of transgenic mice expressing the ada gene.

T. Wagner, S. Gerson, J. Yun, 1991, Cancer research.

Lentiviruses: Vectors for Cancer Gene Therapy

S. Gerson, Amar B. Desai, Yuan Lin, 2010 .

Transgenic expression of human MGMT protects against azoxymethane-induced aberrant crypt foci and G to A mutations in the K-ras oncogene of mouse colon.

T. P. Pretlow, S. Gerson, E. Allay, 1995, Carcinogenesis.

Fetal liver hematopoietic stem cells as a target for in utero retroviral gene transfer

M. Hatzoglou, S. Gerson, D. Clapp, 1991 .

Increase in nitrosourea resistance in mammalian cells by retrovirally mediated gene transfer of bacterial O6-alkylguanine-DNA alkyltransferase.

M. Hatzoglou, S. Abboud, S. Gerson, 1989, Cancer research.

Epigenetic Loss of MLH1 Expression in Normal Human Hematopoietic Stem Cell Clones is Defined by the Promoter CpG Methylation Pattern Observed by High-Throughput Methylation Specific Sequencing

Shuying Sun, E. Arts, Xiaodong Bai, 2016, International journal of stem cell research and therapy.

Myeloid Krüppel-like factor 2 is a critical regulator of metabolic inflammation

A. Wynshaw-Boris, Vinesh Vinayachandran, S. Gerson, 2020, Nature Communications.

Models for Gene Therapy

S. Gerson, Yuan Lin, C. Sweeney, 2007 .

Concepts and challenges in cancer risk prediction for the space radiation environment.

Mary Helen Barcellos-Hoff, Lynn Hlatky, David G Kirsch, 2015, Life sciences in space research.

Impaired growth and elevated fas receptor expression in PIGA(+) stem cells in primary paroxysmal nocturnal hemoglobinuria.

H. Lazarus, R. Chen, D. Kaplan, 2000, The Journal of clinical investigation.

Advances in therapeutic targeting of the DNA damage response in cancer.

S. Gerson, Amar B. Desai, Yan Yan, 2018, DNA repair.

Splenectomy and the induction of murine colon cancer.

S. Gerson, T. Stellato, N. Gordon, 1988, Archives of surgery.

Antiemetic efficacy of high-dose dexamethasone in induction therapy in acute nonlymphocytic leukemia.

E. Lusk, S. Gerson, P. Cassileth, 1984, Annals of internal medicine.

Mesenchymal stem cells: No longer second class marrow citizens

S. Gerson, 1999, Nature Medicine.

Phenotypic and functional comparison of cultures of marrow‐derived mesenchymal stem cells (MSCs) and stromal cells

S. Gerson, J. Mosca, M. Moorman, 1998, Journal of cellular physiology.

Differential sensitivity of human and mouse alkyltransferase to O6-benzylguanine using a transgenic model.

S. Gerson, E. Wasan, K. Lee, 1996, Cancer research.

Bone Marrow‐Derived Cells Exhibiting Lung Epithelial Cell Characteristics Are Enriched In Vivo Using Methylguanine DNA Methyltransferase‐Mediated Drug Resistance

S. Gerson, J. Reese, Justin C. Roth, 2008, Stem cells.

The History of Stem Cell Transplantation

S. Gerson, H. Lazarus, 2016 .

Cotransplantation of HLA-identical sibling culture-expanded mesenchymal stem cells and hematopoietic stem cells in hematologic malignancy patients.

Andrea Bacigalupo, Philip McCarthy, E. Shpall, 2005, Biology of blood and marrow transplantation : journal of the American Society for Blood and Marrow Transplantation.

Rapid Hematopoiet ic Recovery Af ter Coinfus ion of Autologous-Blood Stem Cel ls and Culture-Expanded Marrow Mesenchymal Stem Cel ls in Advanced Breast Cancer

S. Gerson, A. Caplan, H. Lazarus, 1999 .

New Opportunities and Challenges to Defeat Cancer Stem Cells.

S. Gerson, Huiping Liu, Erika K. Ramos, 2017, Trends in cancer.

AF1q Is a Novel Poor Prognostic Marker for Adult Acute Myelogenous Leukemia (AML) Patients with Normal Cytogenetics.

W. Tse, S. Gerson, G. Ehninger, 2005 .

Marked inactivation of O6-alkylguanine-DNA alkyltransferase activity with protracted temozolomide schedules

A. Tolcher, C. Geyer, L. Denis, 2003, British Journal of Cancer.

DNA repair defects in stem cell function and aging.

S. Gerson, Young-jin Park, 2005, Annual review of medicine.

CARCINOGENESIS AND DNA REPAIR IN TRANSGENIC MICE

S. Gerson, L. Dumenco, 1992 .

An unusual case of autoimmune hemolytic anemia with reticulocytopenia, erythroid dysplasia, and an IgG2 autoanti‐U

S. Gerson, N. Rosenthal, N. Hirschler, 1996, Transfusion.

Recombinant granulocyte-macrophage colony-stimulating factor after autologous bone marrow transplantation for relapsed non-Hodgkin's lymphoma: blood and bone marrow progenitor growth studies. A phase II Eastern Cooperative Oncology Group Trial.

M. Oken, S. Gerson, H. Lazarus, 1991, Blood.

Developmental and Potential Therapeutic Aspects of Mammalian Neural Stem Cells

R. Miller, S. Gerson, L. Bai, 2006 .

Prospective Study of Single vs. Two Unit Umbilical Cord Blood Transplantation Following Reduced Intensity Conditioning in Adults with Hematologic Malignancies

Y. Hegerfeldt, P. Fu, S. Gerson, 2011, Bone Marrow Transplantation.

Identification of 6-benzylthioinosine as a myeloid leukemia differentiation-inducing compound.

B. Roth, W. Tse, M. Agarwal, 2008, Cancer research.

DNA repair in stem cell maintenance and conversion to cancer stem cells.

S. Gerson, J. Kenyon, J. Reese, 2006, Ernst Schering Foundation symposium proceedings.

Hematopoietic Progenitor Cell Harvesting Is Feasible after Treatment with Brentuximab Vedotin in CD30(+) Lymphoma Patients Who Received Multiple Prior Lines of Treatment.

Y. Nieto, U. Popat, S. Gerson, 2015, Biology of blood and marrow transplantation : journal of the American Society for Blood and Marrow Transplantation.

In vitro treatment of autologous bone marrow for neuroblastoma patients with anti GD2 monoclonal antibody and human complement: a pilot study.

D. V. Von Hoff, N. Cheung, S. Gerson, 1988, Progress in clinical and biological research.

Gestational age-dependent changes in circulating hematopoietic stem cells in newborn infants.

S. Gerson, D. Clapp, J. Baley, 1989, The Journal of laboratory and clinical medicine.

Loss of Uracil DNA Glycosylase Selectively Resensitizes p53-Mutant and -Deficient Cells to 5-FdU

J. Pink, S. Gerson, Yulan Qing, 2017, Molecular Cancer Research.

Distinct roles of resident and nonresident macrophages in nonischemic cardiomyopathy

J. Stamler, A. Alaiti, A. Wynshaw-Boris, 2018, Proceedings of the National Academy of Sciences.

MMR Deficiency Does Not Sensitize or Compromise the Function of Hematopoietic Stem Cells to Low and High LET Radiation

S. Welford, J. Pink, S. Gerson, 2018, Stem cells translational medicine.

Systemic deficits in transporter for antigen presentation (TAP)‐1 or proteasome subunit LMP2 have little or no effect on tumor incidence

F. Abdul-Karim, M. Sy, C. Harding, 2001, International journal of cancer.

Tumor-selective use of DNA base excision repair inhibition in pancreatic cancer using the NQO1 bioactivatable drug, β-lapachone

R. Deberardinis, D. Gerber, Jinming Gao, 2015, Scientific Reports.

A phase 1 study of TRC102, an inhibitor of base excision repair, and pemetrexed in patients with advanced solid tumors

G. Weiss, Lili Liu, W. Figg, 2013, Investigational New Drugs.

Issues in Moving Gene Therapy Approaches to Early Clinical Trials

J. Grandis, S. Gerson, S. Thomas, 2014 .

Quantitative immunohistochemical estimates of O6-alkylguanine-DNA alkyltransferase expression in normal and malignant human colon.

S. Gerson, L. Liu, N. H. Zaidi, 1996, Clinical cancer research : an official journal of the American Association for Cancer Research.

Dual institution experience of extranodal marginal zone lymphoma reveals excellent long‐term outcomes

P. Fu, Arun D. Singh, S. Gerson, 2016, British journal of haematology.

Results of a phase i clinical trial of allogeneic mesenchymal stem cell (msc) transplantation in patients with hurlerdisease and metachromaticleukodystrophy (mld)

S. Gerson, A. Caplan, H. Lazarus, 2000 .

Bcl2 overexpression rescues the hematopoietic stem cell defects in Ku70-deficient mice by restoration of quiescence.

S. Gerson, Zhengqi Wang, Yulan Qing, 2014, Blood.

High-dose carmustine, etoposide, and cisplatin for autologous stem cell transplantation with or without involved-field radiation for relapsed/refractory lymphoma: an effective regimen with low morbidity and mortality.

P. Fu, S. Gerson, H. Lazarus, 2005, Biology of blood and marrow transplantation : journal of the American Society for Blood and Marrow Transplantation.

Targeting base excision repair suggests a new therapeutic strategy of fludarabine for the treatment of chronic lymphocytic leukemia

S. Gerson, E. B. Kirkland, L. Li, 2010, Leukemia.

Two‐Photon Fluorescent Imaging of Myelination in the Spinal Cord

S. Gerson, Robert H Miller, Yanming Wang, 2012, ChemMedChem.

Differential effects of phorbol esters on normal myeloid precursors and leukemic cells: basis for autologous bone marrow reconstitution in acute nonlymphocytic leukemia using phorbol ester-treated bone marrow from patients in remission.

J. Hoxie, J. Abrahm, S. Gerson, 1986, Cancer research.

New cytotoxic agents for the treatment of metastatic malignant melanoma: temozolomide and related alkylating agents in combination with guanine analogues to abrogate drug resistance.

S. Gerson, T. Spiro, L. Liu, 2000, Forum.

Combined Treatment with Temozolomide and Methoxyamine: Blocking Apurininc/Pyrimidinic Site Repair Coupled with Targeting Topoisomerase IIα

Lili Liu, S. Gerson, Varun Mahajan, 2007, Clinical Cancer Research.

Polypharmacy in fatal clozapine-associated agranulocytosis

J. Lieberman, S. Gerson, W. Friedenberg, 1991, The Lancet.

Unsuccessful reexposure to clozapine.

F. Frankenburg, S. Gerson, D. Stormberg, 1994, Journal of Clinical Psychopharmacology.

G-CSF and the management of clozapine-induced agranulocytosis.

S. Gerson, Stanton L. Gerson, 1994, The Journal of clinical psychiatry.

Candidate gene analysis identifies a polymorphism in HLA-DQB1 associated with clozapine-induced agranulocytosis.

A. Malhotra, M. Athanasiou, T. Lencz, 2011, The Journal of clinical psychiatry.

Granulocyte colony-stimulating factor for clozapine-induced agranulocytosis

S. Gerson, H. Yeh, G. Gullion, 1992, The Lancet.

A Phase 1 Study of TRC 102 , An Inhibitor of Base Excision Repair , and Pemetrexed in Patients with Advanced Solid Tumors

G. Weiss, W. Figg, L. Rosen, 2017 .

Phase I Trial of the Base – Excision Repair Blocker Methoxyamine (TRC-102) Combined with Fludarabine in Relapsed/Refractory Chronic Lymphocytic Leukemia (CLL) and Lymphoid Malignancies

J. Pink, A. Dowlati, S. Gerson, 2014 .

Development and validation of an LC-MS/MS method for pharmacokinetic study of methoxyamine in phase I clinical trial.

Lili Liu, Yan Xu, S. Gerson, 2012, Journal of chromatography. B, Analytical technologies in the biomedical and life sciences.

Removal of uracil by uracil DNA glycosylase limits pemetrexed cytotoxicity: overriding the limit with methoxyamine to inhibit base excision repair

S. Markowitz, N. Oleinick, S. Gerson, 2012, Cell Death and Disease.

Prevention of base excision repair by TRC102 (methoxyamine) potentiates the anti-tumor activity of pemetrexed in vitro and in vivo

Lili Liu, S. Gerson, C. Theuer, 2007 .

Comparison of 2 Carmustine-Containing Regimens in the Rituximab Era: Excellent Outcomes Even in Poor-Risk Patients.

P. Fu, S. Gerson, H. Lazarus, 2015, Biology of blood and marrow transplantation : journal of the American Society for Blood and Marrow Transplantation.

Limiting numbers of G156A O(6)-methylguanine-DNA methyltransferase-transduced marrow progenitors repopulate nonmyeloablated mice after drug selection.

S. Gerson, O. Koç, B. M. Davis, 2000, Blood.

Time-dependent effect of non-Hodgkin's lymphoma grade on disease-free survival of relapsed/refractory patients treated with high-dose chemotherapy plus autotransplantation.

P. Fu, S. Gerson, H. Lazarus, 2008, Contemporary clinical trials.

A second-generation 15-PGDH inhibitor promotes bone marrow transplant recovery independently of age, transplant dose and granulocyte colony-stimulating factor support

L. Kasturi, S. Markowitz, D. Dawson, 2018, Haematologica.

Bioluminescence imaging of hematopoietic stem cell repopulation in murine models.

Z. Lee, S. Gerson, Yuan Lin, 2008, Methods in molecular biology.

An effective human uracil-DNA glycosylase inhibitor targets the open pre-catalytic active site conformation

J. Tainer, J. Pink, David S. Shin, 2021, Progress in biophysics and molecular biology.

High UDG and BRCA1 expression is associated with adverse outcome in patients with pemetrexed treated non-small cell lung Cancer.

N. Sharma, T. Mekhail, P. Fu, 2018, Lung cancer.

Exo1 independent DNA mismatch repair involves multiple compensatory nucleases.

S. Gerson, Amar B. Desai, 2014, DNA repair.

Dual institution experience of nodal marginal zone lymphoma reveals excellent long‐term outcomes in the rituximab era

P. Fu, S. Gerson, H. Lazarus, 2016, British journal of haematology.

Outcomes of allogeneic hematopoietic stem cell transplantation for lymphomas: a single-institution experience

P. Fu, S. Gerson, H. Lazarus, 2016, Revista brasileira de hematologia e hemoterapia.

Socioeconomic Factors and Survival of Multiple Myeloma Patients

P. Fu, S. Gerson, M. de Lima, 2021, Cancers.

Gold Nanoparticle-Based Fluorescent Theranostics for Real-Time Image-Guided Assessment of DNA Damage and Repair

C. Burda, S. Gerson, R. Seenivasan, 2019, International journal of molecular sciences.

Splenic marginal zone lymphoma: excellent outcomes in 64 patients treated in the rituximab era

P. Fu, S. Gerson, H. Lazarus, 2017, Hematology.

Quantitative H2S-mediated protein sulfhydration reveals metabolic reprogramming during the integrated stress response

Charles R. Evans, P. Arvan, M. Parisien, 2015, eLife.

Status of Cancer Care at Network Sites of the Nation's Academic Cancer Centers.

R. Holcombe, L. Weiner, Carrie Lee, 2021, Journal of the National Comprehensive Cancer Network : JNCCN.

In vivo Quantification of Abasic Sites for Efficacious Evaluation of DNA Targeted Chemotherapies

Lili Liu, Yuguo Li, S. Gerson, 2012 .

Adding Base-Excision Repair Inhibitor TRC102 to Standard Pemetrexed–Platinum–Radiation in Patients with Advanced Nonsquamous Non–Small Cell Lung Cancer: Results of a Phase I Trial

N. Oleinick, J. Pink, P. Fu, 2021, Clinical cancer research : an official journal of the American Association for Cancer Research.

Uracil–DNA Glycosylase Expression Determines Human Lung Cancer Cell Sensitivity to Pemetrexed

P. Fu, S. Gerson, L. Weeks, 2013, Molecular Cancer Therapeutics.

Mlh1 deficiency increases the risk of hematopoietic malignancy after simulated space radiation exposure.

S. Welford, M. Hoenerhoff, S. Gerson, 2018, Leukemia.

Humans accumulate microsatellite instability with acquired loss of MLH1 protein in hematopoietic stem and progenitor cells as a function of age.

P. Fu, S. Gerson, J. Kenyon, 2012, Blood.

A phase I study of MGMT-P140K transfected hematopoetic progenitor cells (HPC) combined with TMZ/O6BG dose escalation for newly diagnosed, MGMT unmethylated glioblastoma: Tolerance and evidence of survival benefit.

A. Sloan, C. Murphy, S. Gerson, 2019, Journal of Clinical Oncology.

Radiosensitization of non-small-cell lung cancer cells and xenografts by the interactive effects of pemetrexed and methoxyamine.

N. Sharma, N. Oleinick, Junran Zhang, 2016, Radiotherapy and oncology : journal of the European Society for Therapeutic Radiology and Oncology.

TargetedModulation ofMGMT : Clinical Implications

Lili Liu, S. Gerson, 2006 .

Progressive Emergence of a Dominant Unit during Dual Unit Umbilical Cord Blood (UCB) Culture.

Min Liu, S. Gerson, J. Reese, 2005 .

4: Influence of HLA Disparity and Graft Lymphocytes on Allogeneic Engraftment and Survival after Umbilical Cord Blood Transplant in Adults

W. Tse, P. Fu, S. Gerson, 2007 .

Impact of Regional Income and Insurance Status on Survival of Multiple Myeloma Patients: Autologous Stem Cell Transplant as an Equalizer

P. Fu, S. Gerson, M. Gallogly, 2019, Clinical Lymphoma Myeloma and Leukemia.

Inhibition of 15-PGDH Protects Mice from Immune-mediated Bone Marrow Failure

S. Markowitz, S. Gerson, J. Smith, 2020, bioRxiv.

Demographic characteristics of smoldering multiple myeloma patients: A hospital-based study including 11,643 patients.

S. Gerson, M. Gallogly, P. Caimi, 2019, Journal of Clinical Oncology.

Identification of early relapsing patients with adult acute nonlymphocytic leukemia by bone marrow biopsy after initial induction chemotherapy.

E. Lusk, S. Gerson, S. Hurwitz, 1984, Journal of clinical oncology : official journal of the American Society of Clinical Oncology.

15-PGDH regulates hematopoietic and gastrointestinal fitness during aging

L. Kasturi, S. Markowitz, D. Dawson, 2021, bioRxiv.

Regulation of the hut operons of Salmonella typhimurium and Klebsiella aerogenes by the heterologous hut repressors

B. Magasanik, S. Gerson, 1975, Journal of bacteriology.

Current progress in the gene therapy of cancer.

S. Gerson, O. Koç, K. Lee, 1996, Current Opinion in Oncology.

1006. Preliminary Results of a Phase I Trial Using Retroviral Gene Transfer of G156A MGMT To Protect Hematopoiesis during BG and BCNU Therapy of Advanced Malignancies

S. Gerson, O. Koç, J. Reese, 2004 .

Preemptive Rituximab Treatment May Reduce the Incidence of Post-Transplant Lymphoproliferative Disorders (PTLD) In Patients with EBV Reactivation after Allogeneic Stem Cell Transplantation

S. Gerson, H. Lazarus, B. Cooper, 2009 .

DeltaMGMT-transduced bone marrow infusion increases tolerance to O6-benzylguanine and 1,3-bis(2-chloroethyl)-1-nitrosourea and allows intensive therapy of 1,3-bis(2-chloroethyl)-1-nitrosourea-resistant human colon cancer xenografts.

S. Gerson, O. Koç, J. Reese, 1999, Human gene therapy.

Non-Lineage/Stage Restricted Effects of a Gain-of-Function Mutation in Tyrosine Phosphatase Ptpn11 (Shp2) on Malignant Transformation of Hematopoietic Cells

S. Gerson, H. Meyerson, C. Qu, 2011 .

Repair of O6-alkylguanine during DNA synthesis in murine bone marrow hematopoietic precursors.

S. Gerson, K. Miller, J. Trey, 1987, Cancer research.

Altered growth characteristics of murine hematopoietic cells induced by cytotoxic drugs

S. Gerson, S. Robinson, P. L. Page, 1982 .

Gene therapy of cancer : translational approaches from preclinical studies to clinical implementation

S. Gerson, E. Lattime, 1999 .

Chapter 57 – Pharmacology and Molecular Mechanisms of Antineoplastic Agents for Hematologic Malignancies

S. Gerson, P. Caimi, R. Creger, 2017 .

Allogeneic mesenchymal stem cell infusion for treatment of metachromatic leukodystrophy (MLD) and Hurler syndrome (MPS-IH)

S. Gerson, H. Lazarus, O. Koç, 2002, Bone Marrow Transplantation.

Prospective Phase II Study of Biologic Assignment One Vs Two Unit Umbilical Cord Blood Transplant (UCBT) in the Reduced-Intensity Conditioning Setting.

Y. Hegerfeldt, P. Fu, S. Gerson, 2008 .

Pharmacokinetic profile of the base-excision repair inhibitor methoxyamine-HCl (TRC102; MX) given as an one-hour intravenous infusion with temozolomide (TMZ) in the first-in-human phase I clinical trial.

Lili Liu, A. Dowlati, S. Gerson, 2010 .

Impact of age, antiretroviral therapy, and cancer on epigenetic aging in people living with HIV

J. Pink, P. Fu, S. Gerson, 2023, Cancer medicine.

The immature thymocyte is protected from N-methylnitrosourea-induced lymphoma by the human MGMT-CD2 transgene.

B. F. Li, M. Sy, S. Gerson, 1995, Carcinogenesis.

Molecular epidemiology of therapy‐related leukemias

S. Gerson, 1993, Current opinion in oncology.

Acquired resistance to O6-benzylguanine plus chloroethylnitrosoureas in human breast cancer.

S. Gerson, W. Phillips, 1999, Cancer chemotherapy and pharmacology.

A Phase II Study of Curcumin and Vitamin D in Previously Untreated Patients with Early Stage Chronic Lymphocytic Leukemia (CLL) or Small Lymphocytic Lymphoma (SLL)

J. Jacobberger, P. Fu, S. Gerson, 2018, Blood.

Repopulating defect of mismatch repair-deficient hematopoietic stem cells.

Lili Liu, S. Gerson, J. Reese, 2003, Blood.

Viral Insertion Site Detection and Analysis in Cancer Gene Therapy

S. Gerson, H. Fung, 2014 .

Future cancer research priorities in the USA: a Lancet Oncology Commission.

Mark E. Davis, E. Mardis, A. Butte, 2017, The Lancet Oncology.

Inhibition of the prostaglandin-degrading enzyme 15-PGDH potentiates tissue regeneration

K. Bae, J. Sanabria, L. Kasturi, 2015, Science.

CD133+ cells contribute to radioresistance via altered regulation of DNA repair genes in human lung cancer cells.

S. Gerson, Amar B. Desai, B. Webb, 2014, Radiotherapy and oncology : journal of the European Society for Therapeutic Radiology and Oncology.

Phase I Trial of VNP40101M (Cloretazine) in Children with Recurrent Brain Tumors: A Pediatric Brain Tumor Consortium Study

I. Pollack, H. Friedman, R. Packer, 2008, Clinical Cancer Research.

Heterozygous DNA mismatch repair gene PMS2-knockout mice are susceptible to intestinal tumor induction with N-methyl-N-nitrosourea.

D. Shibata, S. Gerson, X. Qin, 2000, Carcinogenesis.

Pulmonary cavitation and massive hemoptysis in invasive pulmonary aspergillosis. Influence of bone marrow recovery in patients with acute leukemia.

S. Albelda, S. Gerson, G. Talbot, 1985, The American review of respiratory disease.

Bcl2 overexpression rescues the hematopoietic stem cell defects in Ku70-deficient mice by restoration of quiescence.

S. Gerson, Zhengqi Wang, Yulan Qing, 2014, Blood.

Mycobacterium tuberculosis infection and cytogenetic abnormalities among people with HIV.

M. Nabwana, S. Gerson, W. Worodria, 2023, Mutation research. Genetic toxicology and environmental mutagenesis.

Hematopoietic Progenitor Cell Harvesting Is Feasible after Treatment with Brentuximab Vedotin in CD30(+) Lymphoma Patients Who Received Multiple Prior Lines of Treatment.

Y. Nieto, U. Popat, S. Gerson, 2015, Biology of blood and marrow transplantation : journal of the American Society for Blood and Marrow Transplantation.

Comparative analysis of breast cancer contamination in mobilized and nonmobilized hematopoietic grafts.

H. Lazarus, A. A. Ross, N. Davidson, 1996, Journal of hematotherapy.