J. Tremblay

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Novel Targets for the Transcription Factors MEF2 in MA-10 Leydig Cells1

M. Di-Luoffo, C. Daems, F. Bergeron, 2015, Biology of reproduction.

MEF2 is restricted to the male gonad and regulates expression of the orphan nuclear receptor NR4A1.

C. Daems, J. Tremblay, Luc J. Martin, 2014, Molecular endocrinology.

Calcium-dependent Nr 4 a 1 expression in mouse Leydig cells requires distinct AP 1 / CRE and MEF 2 elements

Robert, J. Tremblay, Abdou, 2016 .

Calcium-dependent Nr4a1 expression in mouse Leydig cells requires distinct AP1/CRE and MEF2 elements.

J. Tremblay, Houssein S. Abdou, N. Robert, 2016, Journal of molecular endocrinology.

KLF6 cooperates with NUR77 and SF1 to activate the human INSL3 promoter in mouse MA-10 leydig cells.

Maxime A. Tremblay, F. Bergeron, J. Tremblay, 2016, Journal of molecular endocrinology.

MEF2 and NR2F2 cooperate to regulate Akr1c14 gene expression in mouse MA‐10 Leydig cells

M. Di-Luoffo, J. Tremblay, C. Brousseau, 2016, Andrology.

Molecular mechanisms of Ca 2 + signalling in Leydig cells

J. Tremblay, Houssein S. Abdou, N. Robert, 2015 .

The Transcription Factor MEF2 Is a Novel Regulator of Gsta Gene Class in Mouse MA-10 Leydig Cells.

M. Di-Luoffo, F. Bergeron, J. Tremblay, 2015, Endocrinology.

MEF2 Cooperates With Forskolin/cAMP and GATA4 to Regulate Star Gene Expression in Mouse MA-10 Leydig Cells.

M. Di-Luoffo, C. Daems, J. Tremblay, 2015, Endocrinology.

Molecular regulation of steroidogenesis in endocrine Leydig cells

J. Tremblay, 2015, Steroids.

The Human 3β-Hydroxysteroid Dehydrogenase/Δ5-Δ4 Isomerase Type 2 Promoter Is a Novel Target for the Immediate Early Orphan Nuclear Receptor Nur77 in Steroidogenic Cells

J. Tremblay, Luc J. Martin, 2005 .

The Orphan Nuclear Receptor NR4A1 Regulates Insulin-Like 3 Gene Transcription in Leydig Cells1

J. Tremblay, Luc J. Martin, N. Robert, 2006, Biology of reproduction.

The orphan nuclear receptor NUR77 regulates hormone-induced StAR transcription in Leydig cells through cooperation with Ca2+/calmodulin-dependent protein kinase I.

J. Tremblay, Luc J. Martin, C. Brousseau, 2008, Molecular endocrinology.

cAMP-induced expression of the orphan nuclear receptor Nur77 in MA-10 Leydig cells involves a CaMKI pathway.

J. Tremblay, Luc J. Martin, Nicolas P. Boucher, 2008, Journal of andrology.

The nuclear receptors NUR77 and SF1 play additive roles with c-JUN through distinct elements on the mouse Star promoter.

J. Tremblay, Luc J. Martin, 2008, Journal of molecular endocrinology.

The calcium signaling pathway regulates leydig cell steroidogenesis through a transcriptional cascade involving the nuclear receptor NR4A1 and the steroidogenic acute regulatory protein.

J. Tremblay, Houssein S. Abdou, G. Villeneuve, 2013, Endocrinology.

Transcriptional cooperation between NF-kappaB p50 and CCAAT/enhancer binding protein beta regulates Nur77 transcription in Leydig cells.

J. Tremblay, Bassam El-Asmar, Xavier C Giner, 2008, Journal of molecular endocrinology.

Hypoxia-inducible factor-1alpha is constitutively expressed in murine Leydig cells and regulates 3beta-hydroxysteroid dehydrogenase type 1 promoter activity.

Jennifer L. Kirby, J. Tremblay, J. Lysiak, 2008, Journal of andrology.

Expression of the Ladybird-like homeobox 2 transcription factor in the developing mouse testis and epididymis

J. Tremblay, V. Moisan, D. Bomgardner, 2008, BMC Developmental Biology.

Excretion of three major prostatic secretory proteins in the urine of normal men and patients with benign prostatic hypertrophy or prostate cancer

J. Tremblay, R. Tremblay, J. Dubé, 1987 .

The Nuclear Receptor NR2F2 Activates Star Expression and Steroidogenesis in Mouse MA-10 and MLTC-1 Leydig Cells1

J. Tremblay, Luc J. Martin, C. Brousseau, 2014, Biology of reproduction.

The INSL3 gene is a direct target for the orphan nuclear receptor, COUP-TFII, in Leydig cells.

M. Di-Luoffo, J. Tremblay, C. Brousseau, 2014, Journal of molecular endocrinology.

Platelet microparticles are internalized in neutrophils via the concerted activity of 12-lipoxygenase and secreted phospholipase A2-IIA

M. Gelb, G. Lambeau, J. Tremblay, 2015, Proceedings of the National Academy of Sciences.

GATA factors differentially activate multiple gonadal promoters through conserved GATA regulatory elements.

J. Tremblay, R. Viger, 2001, Endocrinology.

Dynamic Expression of the Homeobox Factor PBX1 during Mouse Testis Development

J. Tremblay, C. Brousseau, V. Moisan, 2022, Endocrines.

Transcriptional Properties of Ptx1 and Ptx2 Isoforms

J. Drouin, J. Tremblay, C. Goodyer, 2000, Neuroendocrinology.

/Calmodulin-Dependent Protein Kinase I 2+ Transcription in Leydig Cells through Cooperation with Ca StAR The Orphan Nuclear Receptor NUR77 Regulates Hormone-Induced

J. Tremblay, Luc J. Martin, C. Brousseau, 2008 .

The Orphan Nuclear Receptor NR4A1 Regulates Insulin-Like 3 Gene Transcription in

J. Tremblay, Luc J. Martin, N. Robert, 2006 .

GATA factors and the nuclear receptors, steroidogenic factor 1/liver receptor homolog 1, are key mutual partners in the regulation of the human 3beta-hydroxysteroid dehydrogenase type 2 promoter.

J. Simard, H. Taniguchi, J. Tremblay, 2005, Molecular endocrinology.

Functional cooperation between GATA factors and cJUN on the star promoter in MA-10 Leydig cells.

F. Bergeron, J. Tremblay, Luc J. Martin, 2012, Journal of andrology.

A Mutated Form of Steroidogenic Factor 1 (SF-1 G35E) That Causes Sex Reversal in Humans Fails to Synergize with Transcription Factor GATA-4*

J. Tremblay, R. Viger, Robert S Viger, 2003, Journal of Biological Chemistry.

Nuclear Receptors, Testosterone, and Posttranslational Modifications in Human INSL3 Promoter Activity in Testicular Leydig Cells

J. Tremblay, N. Robert, Éric Laguë, 2009, Annals of the New York Academy of Sciences.

The nuclear receptors SF1 and LRH1 are expressed in endometrial cancer cells and regulate steroidogenic gene transcription by cooperating with AP-1 factors.

F. Bergeron, J. Tremblay, C. Brousseau, 2009, Cancer letters.

Role of Nuclear Receptors in INSL3 Gene Transcription in Leydig Cells

J. Tremblay, N. Robert, 2005, Annals of the New York Academy of Sciences.

Isolation from human seminal plasma of an abundant 16-kDa protein originating from the prostate, its identification with a 94-residue peptide originally described as beta-inhibin.

N. Seidah, M. Chrétien, J. Tremblay, 1987, Journal of andrology.

Pitx1 in vivo Promoter Activity and Mechanisms of Positive Autoregulation

C. Lanctôt, J. Drouin, J. Tremblay, 2003, Neuroendocrinology.

Protein kinase A-dependent cooperation between GATA and CCAAT/enhancer-binding protein transcription factors regulates steroidogenic acute regulatory protein promoter activity.

J. Tremblay, R. Viger, F. Hamel, 2002, Endocrinology.

Friend of GATA (FOG)-1 and FOG-2 differentially repress the GATA-dependent activity of multiple gonadal promoters.

J. Tremblay, R. Viger, N. Robert, 2002, Endocrinology.

Nuclear Receptor Dax-1 Represses the Transcriptional Cooperation Between GATA-4 and SF-1 in Sertoli Cells1

J. Tremblay, R. Viger, Robert S Viger, 2001, Biology of reproduction.

GATA factors differentially activate multiple gonadal promoters through conserved GATA regulatory elements.

J. Tremblay, R. Viger, Robert S Viger, 2001, Endocrinology.

Transcription factor GATA-4 enhances Müllerian inhibiting substance gene transcription through a direct interaction with the nuclear receptor SF-1.

J. Tremblay, R. Viger, Robert S Viger, 1999, Molecular endocrinology.

Transcription of platelet-derived growth factor receptor α in Leydig cells involves specificity protein 1 and 3.

F. Bergeron, J. Tremblay, E. Bagu, 2011, Journal of molecular endocrinology.

New insights into the regulation of mammalian sex determination and male sex differentiation.

J. Tremblay, D. Silversides, R. Viger, 2005, Vitamins and hormones.

Differential Response of Transcription Factors to Activated Kinases in Steroidogenic and Non-Steroidogenic Cells

J. Tremblay, Kenley Joule Pierre, 2022, International journal of molecular sciences.

A Short Promoter Region Containing Conserved Regulatory Motifs Is Required for Steroidogenic Acute Regulatory Protein (Star) Gene Expression in the Mouse Testis

J. Tremblay, R. Viger, Robert S Viger, 2022, International journal of molecular sciences.

TRANSCRIPTION OF PLATELET-DERIVED GROWTH FACTOR RECEPTOR ALPHA IN 1

F. Bergeron, J. Tremblay, E. Bagu, 2011 .

Insights Into the Roles of GATA Factors in Mammalian Testis Development and the Control of Fetal Testis Gene Expression

J. Tremblay, R. Viger, Robert S Viger, 2022, Frontiers in Endocrinology.

Expression of ladybird-like homeobox 2 (LBX2) during ovarian development and folliculogenesis in the mouse

J. Tremblay, N. Robert, V. Moisan, 2010, Journal of Molecular Histology.

The PTX family of homeodomain transcription factors during pituitary developments

C. Lanctôt, J. Drouin, J. Tremblay, 1998, Molecular and Cellular Endocrinology.

Antagonistic effects of testosterone and the endocrine disruptor mono-(2-ethylhexyl) phthalate on INSL3 transcription in Leydig cells.

J. Tremblay, Éric Laguë, 2008, Endocrinology.

A Cell-Autonomous Molecular Cascade Initiated by AMP-Activated Protein Kinase Represses Steroidogenesis

F. Bergeron, J. Tremblay, Houssein S. Abdou, 2014, Molecular and Cellular Biology.

Modulation of endogenous GATA-4 activity reveals its dual contribution to Müllerian inhibiting substance gene transcription in Sertoli cells.

J. Tremblay, R. Viger, N. Robert, 2001, Molecular endocrinology.

Ptx1 regulates SF‐1 activity by an interaction that mimics the role of the ligand‐binding domain

J. Drouin, J. Tremblay, Alexandre Marcil, 1999, The EMBO journal.

Egr-1 Is a Downstream Effector of GnRH and Synergizes by Direct Interaction with Ptx1 and SF-1 To Enhance Luteinizing Hormone β Gene Transcription

J. Drouin, J. Tremblay, 1999, Molecular and Cellular Biology.

A homeodomain gene Ptx3 has highly restricted brain expression in mesencephalic dopaminergic neurons.

G Wolterink, C. Lanctôt, J. Drouin, 1997, Proceedings of the National Academy of Sciences of the United States of America.

Ptx1, a bicoid-related homeo box transcription factor involved in transcription of the pro-opiomelanocortin gene.

M. Therrien, C. Lanctôt, J. Drouin, 1996, Genes & development.

Chicken ovalbumin upstream promoter transcription factor type II interacts and functionally cooperates with GATA4 to regulate anti‐Müllerian hormone receptor type 2 transcription in mouse MA‐10 Leydig cells

J. Tremblay, R. Viger, Robert S Viger, 2022 .

canalicular ecto-ATPase as NTPDase8 Cloning, purification, and identification of the liver

J. Dranoff, B. Künzli, J. Sévigny, 2011 .

Phosphorylation of GATA4 serine 105 but not serine 261 is required for testosterone production in the male mouse

F. Bergeron, J. Tremblay, R. Viger, 2019, Andrology.

Role of the GATA family of transcription factors in andrology.

H. Taniguchi, J. Tremblay, R. Viger, 2004, Journal of Andrology.

Novel roles for GATA transcription factors in the regulation of steroidogenesis

J. Tremblay, R. Viger, Robert S Viger, 2003, The Journal of Steroid Biochemistry and Molecular Biology.

Glucocorticoids antagonize cAMP-induced Star transcription in Leydig cells through the orphan nuclear receptor NR4A1.

J. Tremblay, Luc J. Martin, 2008, Journal of molecular endocrinology.

Transcription Factors as Regulators of Gene Expression During Leydig Cell Differentiation and Function

J. Tremblay, 2007 .

Comprehensive and Quantitative Analysis of the Changes in Proteomic and Phosphoproteomic Profiles during Stimulation and Repression of Steroidogenesis in MA-10 Leydig Cells

J. Tremblay, Zoheir B. Demmouche, 2022, International journal of molecular sciences.

Estradiol represses insulin-like 3 expression and promoter activity in MA-10 Leydig cells.

J. Tremblay, Éric Laguë, 2009, Toxicology.

IL-6 downregulates transcription of NTPDase2 via specific promoter elements.

J. Dranoff, J. Sévigny, J. Tremblay, 2008, American journal of physiology. Gastrointestinal and liver physiology.

Mechanism of Action of an Environmentally Relevant Organochlorine Mixture in Repressing Steroid Hormone Biosynthesis in Leydig Cells

J. Tremblay, J. Bailey, Zoheir B. Demmouche, 2022, International journal of molecular sciences.

Activation of AMPK Actively Represses Steroid Hormone Synthesis in MA-10 Leydig Cells.

J. Tremblay, Houssein S. Abdou, N. Robert, 2012 .

Transient dwarfism and hypogonadism in mice lacking Otx1 reveal prepubescent stage-specific control of pituitary levels of GH, FSH and LH.

P. Macchia, P. Brûlet, A. Simeone, 1998, Development.

Human and murine PTX1/Ptx1 gene maps to the region for Treacher Collins Syndrome

N. Jenkins, M. Crawford, C. Lanctôt, 1997, Mammalian Genome.

The pan-pituitary activator of transcription, Ptx1 (pituitary homeobox 1), acts in synergy with SF-1 and Pit1 and is an upstream regulator of the Lim-homeodomain gene Lim3/Lhx3.

C. Lanctôt, J. Drouin, J. Tremblay, 1998, Molecular endocrinology.

Nuclear Receptors in Leydig Cell Gene Expression and Function1

J. Tremblay, Luc J. Martin, 2010, Biology of reproduction.

FOXA3 Is Expressed in Multiple Cell Lineages in the Mouse Testis and Regulates Pdgfra Expression in Leydig Cells

F. Bergeron, J. Tremblay, C. Brousseau, 2017, Endocrinology.

The Urokinase-Type Plasminogen Activator Contributes to cAMP-Induced Steroidogenesis in MA-10 Leydig Cells

J. Tremblay, Zoheir B. Demmouche, 2022, Endocrines.

Transcription Factors in the Regulation of Leydig Cell Gene Expression and Function

J. Tremblay, R. Viger, Robert S Viger, 2022, Frontiers in Endocrinology.

Growth hormone-induced STAT5B regulates Star gene expression through a cooperation with cJUN in mouse MA-10 Leydig cells.

F. Bergeron, J. Tremblay, C. Brousseau, 2021, Endocrinology.

Mechanisms of MEHP Inhibitory Action and Analysis of Potential Replacement Plasticizers on Leydig Cell Steroidogenesis

J. Tremblay, Annick N Enangue Njembele, 2021, International journal of molecular sciences.

Identification of novel genes and pathways regulated by the orphan nuclear receptor COUP-TFII in mouse MA-10 Leydig cells

J. Tremblay, R. Viger, Raifish E. Mendoza-Villarroel, 2021, Biology of Reproduction.

The Nuclear Receptor COUP-TFII Regulates Amhr2 Gene Transcription via a GC-Rich Promoter Element in Mouse Leydig Cells

J. Tremblay, R. Viger, Raifish E. Mendoza-Villarroel, 2019, Journal of the Endocrine Society.

In Vitro Exposure of Leydig Cells to an Environmentally Relevant Mixture of Organochlorines Represses Early Steps of Steroidogenesis1

J. Tremblay, J. Bailey, Annick N Enangue Njembele, 2014, Biology of reproduction.

Transcription Factor GATA-4 Is Activated by Phosphorylation of Serine 261 via the cAMP/Protein Kinase A Signaling Pathway in Gonadal Cells*

J. Tremblay, R. Viger, 2003, Journal of Biological Chemistry.

A 35-bp Conserved Region Is Crucial for Insl3 Promoter Activity in Mouse MA-10 Leydig Cells

J. Tremblay, N. Robert, Kenley Joule Pierre, 2022, International journal of molecular sciences.

What Signals Testis Descent?

J. Tremblay, 2010, Biology of reproduction.

The human 3beta-hydroxysteroid dehydrogenase/Delta5-Delta4 isomerase type 2 promoter is a novel target for the immediate early orphan nuclear receptor Nur77 in steroidogenic cells.

J. Tremblay, Luc J. Martin, 2005, Endocrinology.

The nuclear receptors SF1 and COUP-TFII cooperate on the Insl3 promoter in Leydig cells.

M. Di-Luoffo, J. Tremblay, N. Robert, 2022, Reproduction.

Transcription of platelet-derive d growth factor receptor a in Leydig cells involves specificity protein 1 and 3

F. Bergeron, J. Tremblay, E. Bagu, 2011 .

Glucocorticoids antagonize cAMP-induced Star transcription in Leydig cells through the orphan nuclear receptor NR4A1.

J. Tremblay, Luc J. Martin, 2008, Journal of molecular endocrinology.

Delta 5-androstenediol: kinetics of metabolism and binding to plasma proteins in normal post-menopausal women.

J. Tremblay, V. Masters, A. Clark, 1982, Acta endocrinologica.

COMMENTARY--What signals testis descent?

J. Tremblay, 2010 .

Hormones and Signaling Pathways Involved in the Stimulation of Leydig Cell Steroidogenesis

J. Tremblay, Kenley Joule Pierre, Karine de Mattos, 2023, Endocrines.

The calcium signaling pathway regulates leydig cell steroidogenesis through a transcriptional cascade involving the nuclear receptor NR4A1 and the steroidogenic acute regulatory protein.

J. Tremblay, Houssein S. Abdou, G. Villeneuve, 2013, Endocrinology.

The nuclear receptors NUR77 and SF1 play additive roles with c-JUN through distinct elements on the mouse Star promoter.

J. Tremblay, Luc J. Martin, 2008, Journal of molecular endocrinology.

J. Tremblay, R. Viger, S. Mehanovic, 2022, Andrology.

Expression of the Ladybird-like homeobox 2 transcription factor in the developing mouse testis and epididymis

J. Tremblay, V. Moisan, D. Bomgardner, 2008, BMC Developmental Biology.