I. Rietjens

发表

Opinion of the Scientific Panel on Food Additives, Flavourings, Processing Aids and Materials in contact with Food (AFC) on a request from the Commission

Paul Tobback, Fernando Aguilar, Nathalie Gontard, 2008 .

The use of adverse outcome pathways in the safety evaluation of food additives

Timothy E. H. Allen, M. Vinken, A. Boobis, 2020, Archives of Toxicology.

Comparative biotransformation of hexachlorobenzene and hexafluorobenzene in relation to the induction of porphyria.

P. van Bladeren, B. van Ommen, I. Rietjens, 1995, European journal of pharmacology.

pH-Dependent radical scavenging capacity of green tea catechins.

I. Rietjens, A. Gliszczyńska-Świgło, Małgorzata Muzolf, 2008, Journal of agricultural and food chemistry.

Scientific Opinion on the re-evaluation Tartrazine (E 102) on request from the European Commission: Question No EFSA-Q-2008-222

P. Galtier, J. Larsen, R. Woutersen, 2009 .

Safety assessment of plant food supplements (PFS).

L. Serra-Majem, P. Coppens, I. Rietjens, 2011, Food & function.

The safety evaluation of food flavouring substances: the role of metabolic studies.

Sean V. Taylor, Christie L Harman, Samuel M. Cohen, 2018, Toxicology research.

Biotransfiormation and Toxicity of Halogenated Benzenes

P. van Bladeren, A. Brouwer, I. Rietjens, 1994, Human & experimental toxicology.

Influence of the type of halogen substituent on in vivo and in vitro phase II metabolism of 2-fluoro-4-halophenol metabolites formed from 3-halo-fluorobenzenes.

I. Rietjens, C. Veeger, A. Soffers, 1994, Xenobiotica; the fate of foreign compounds in biological systems.

The involvement of primary and secondary metabolism in the covalent binding of 1,2- and 1,4-dichlorobenzenes.

P. van Bladeren, I. Rietjens, I. Rietjens, 1992, Chemico-biological interactions.

A mechanism for oxygen exchange between ligated oxometalloporphinates and bulk water.

I. Rietjens, C. Veeger, J. Primus, 2000, Biochemical and biophysical research communications.

FEMA expert panel review of p-mentha-1,8-dien-7-al genotoxicity testing results.

Sean V. Taylor, Christie L Harman, Samuel M. Cohen, 2016, Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association.

In vitro assays for hazard identification of nanoparticles

I. Rietjens, Samantha K. Kloet, N. W. Brink, 2011 .

Monitoring of polycyclic aromatic hydrocarbons (PAH) in food supplements containing botanicals and other ingredients on the Dutch market

M. Grutters, I. Rietjens, M. Martena, 2011, Food additives & contaminants. Part A, Chemistry, analysis, control, exposure & risk assessment.

Chronic quercetin exposure affects fatty acid catabolism in rat lung

I. Arts, V. D. Boer, P. Hollman, 2006, Cellular and Molecular Life Sciences CMLS.

Computer-modeling-based QSARs for analyzing experimental data on biotransformation and toxicity.

J. Hermens, J. Vervoort, I. Rietjens, 2001, Toxicology in vitro : an international journal published in association with BIBRA.

FEMA GRAS assessment of natural flavor complexes: Mint, buchu, dill and caraway derived flavoring ingredients.

Sean V. Taylor, Jeanne M. Davidsen, Christie L Harman, 2019, Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association.

The Regulatory Framework Across International Jurisdictions for Risks Associated with Consumption of Botanical Food Supplements.

I. Rietjens, L. D. de Haan, Teng Yong Low, 2017, Comprehensive reviews in food science and food safety.

Undesired Plant-Derived Components in Food

D. Schrenk, I. Rietjens, B. Dusemund, 2017 .

Integrating in vitro data and physiologically based kinetic modeling-facilitated reverse dosimetry to predict human cardiotoxicity of methadone

H. Bouwmeester, I. Rietjens, I. Rietjens, 2020, Archives of Toxicology.

Mode of action-based risk assessment of genotoxic carcinogens

P. Steinberg, A. Hartwig, A. Lampen, 2020, Archives of Toxicology.

Frontier orbital study on the 4-hydroxybenzoate-3-hydroxylase-dependent activity with benzoate derivatives.

J. Vervoort, I. Rietjens, W. V. van Berkel, 1992, European journal of biochemistry.

Enzymatic Baeyer–Villiger Oxidation of Benzaldehydes

W. Berkel, I. Rietjens, A. Westphal, 2005 .

Biotransformation of 2‐fluoroaniline in rats studied by In Vivo 19F NMR

C. Moonen, J. Vervoort, M. von Kienlin, 1991, NMR in biomedicine.

Scientific Opinion on the public health hazards to be covered by inspection of meat from sheep and goats

J. Sofos, T. Hald, A. Bøtner, 2013, EFSA journal. European Food Safety Authority.

FEMA GRAS assessment of natural flavor complexes: Citrus-derived flavoring ingredients.

Sean V. Taylor, Jeanne M. Davidsen, Christie L Harman, 2019, Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association.

Safety assessment of smoke flavouring primary products by the European Food Safety Authority

D. Meier, K. Engel, D. Gott, 2012 .

Nitrate and nitrite in the diet: how to assess their benefit and risk for human health.

S. Vieths, P. Steinberg, D. Marko, 2015, Molecular nutrition & food research.

Glutathione pathway enzyme activities and the ozone sensitivity of lung cell populations derived from ozone exposed rats.

I. Rietjens, G. Alink, L. van Bree, 1985, Toxicology.

The FEMA GRAS assessment of alpha,beta-unsaturated aldehydes and related substances used as flavor ingredients.

L. Marnett, V. Feron, W. J. Waddell, 2008, Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association.

Quercetin decreases high-fat diet induced body weight gain and accumulation of hepatic and circulating lipids in mice

P. Hollman, J. Vervoort, J. Keijer, 2014, Genes & Nutrition.

5‐fluorouracil metabolite patterns in viable and necrotic tumor areas of murine colon carcinoma determined by 19F NMR spectroscopy

A. Heerschap, G. Rosenbusch, J. Vervoort, 1996, Magnetic resonance in medicine.

Characterizing the coverage of critical effects relevant in the safety evaluation of food additives by AOPs

Timothy E. H. Allen, M. Vinken, A. Boobis, 2019, Archives of Toxicology.

19F Nuclear Magnetic Resonance as a Tool To Investigate Microbial Degradation of Fluorophenols to Fluorocatechols and Fluoromuconates

J. Vervoort, I. Rietjens, W. V. van Berkel, 1998, Applied and Environmental Microbiology.

Calculated ionisation potentials determine the oxidation of vanillin precursors by lignin peroxidase

I. Rietjens, J. Field, R. ten Have, 1998, FEBS letters.

Direct comparison of metabolic health effects of the flavonoids quercetin, hesperetin, epicatechin, apigenin and anthocyanins in high-fat-diet-fed mice

P. Hollman, J. Vervoort, J. Keijer, 2015, Genes & Nutrition.

FEMA GRAS assessment of natural flavor complexes: Clove, Cinnamon leaf and West Indian bay leaf-derived flavoring ingredients.

Sean V. Taylor, Jeanne M. Davidsen, Christie L Harman, 2020, Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association.

FEMA GRAS assessment of natural flavor complexes: Lavender, Guaiac Coriander-derived and related flavoring ingredients.

Sean V. Taylor, Jeanne M. Davidsen, Christie L Harman, 2020, Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association.

Exposure assessment of process-related contaminants in food by biomarker monitoring

A. Mally, A. Seidel, J. Swenberg, 2018, Archives of Toxicology.

Interlaboratory comparison of microsomal ethoxyresorufin and pentoxyresorufin O-dealkylation determinations: standardization of assay conditions

H. Wortelboer, I. Rietjens, B. Blaauboer, 2006, Archives of Toxicology.

Interference of flavonoids with enzymatic assays for the determination of free fatty acid and triglyceride levels

P. Hollman, J. Keijer, E. V. van Schothorst, 2011, Analytical and Bioanalytical Chemistry.

TECHNICAL NOTE

P. Hollman, J. Keijer, I. Rietjens, 2003 .

Reaction pathways for biodehalogenation of fluorinated anilines.

J. Vervoort, I. Rietjens, B. Tyrakowska, 1990, European journal of biochemistry.

The interplay of glutathione-related processes in antioxidant defense.

P. van Bladeren, H. Wortelboer, J. V. van Zanden, 2001, Environmental toxicology and pharmacology.

In vitro metabolism of 5-fluoro-2-glutathionyl-nitrobenzene by kidney proximal tubular cells studied by 19F-NMR.

P. van Bladeren, J. Vervoort, I. Rietjens, 1995, Chemico-biological interactions.

Identification of the human P450 enzymes involved in the in vitro metabolism of the synthetic steroidal hormones Org 4060 and Org 30659

I. Rietjens, R. Vos, G. Groothuis, 2002, Xenobiotica; the fate of foreign compounds in biological systems.

MP8-dependent oxidative dehalogenation: evidence for the direct formation of 1,4-benzoquinone from 4-fluorophenol by a peroxidase-type of reaction pathway.

A. Osman, I. Rietjens, C. Veeger, 1997, Chemico-biological interactions.

Metabolism of the insecticide teflubenzuron in rats.

N. Cnubben, I. Rietjens, J. Koerts, 1997, Xenobiotica; the fate of foreign compounds in biological systems.

1H NMR T 1 relaxation rate study on substrate orientation of fluoromethylanilines in the active sites of microsomal and purified cytochromes P450 1A1 and 2B1

J. Vervoort, I. Rietjens, J. Koerts, 1995, FEBS letters.

Different metabolic pathways of 2,5-difluoronitrobenzene and 2,5-difluoroaminobenzene compared to molecular orbital substrate characteristics.

J. Vervoort, N. Cnubben, I. Rietjens, 1995, Chemico-biological interactions.

Study on the regioselectivity and mechanism of the aromatic hydroxylation of monofluoroanilines.

J. Vervoort, N. Cnubben, I. Rietjens, 1992, Chemico-biological interactions.

The effect of age on inducibility of various types of rat liver cytochrome P-450.

I. Rietjens, G. Horbach, P. Kremers, 1992, Xenobiotica; the fate of foreign compounds in biological systems.

Radical scavenging capacity of wine anthocyanins is strongly pH-dependent.

I. Rietjens, H. Szymusiak, B. Tyrakowska, 2005, Journal of agricultural and food chemistry.

Prediction of in vivo developmental toxicity of all-trans-retinoic acid based on in vitro toxicity data and in silico physiologically based kinetic modeling

I. Rietjens, I. Rietjens, B. Blaauboer, 2014, Archives of Toxicology.

Methyl linoleate ozonide as a substrate for rat glutathione S-transferases: reaction pathway and isoenzyme selectivity.

P. van Bladeren, I. Rietjens, R. Vos, 1989, Chemico-biological interactions.

Catabolism of 4-hydroxybenzoate in Candida parapsilosis proceeds through initial oxidative decarboxylation by a FAD-dependent 4-hydroxybenzoate 1-hydroxylase.

M. Eppink, J. Vervoort, I. Rietjens, 1994, FEMS microbiology letters.

Catabolism of 4-hydroxybenzoate in proceeds through initial oxidative decarboxylation by a FAD-dependent 4-hydroxybenzoate 1-hydroxylase

M. Eppink, J. Vervoort, I. Rietjens, 1994 .

Molecular orbital study on the glutathione-dependent detoxication of ozonides.

I. Rietjens, J. de Vries, R. Hempenius, 1992, European journal of pharmacology.

The safety evaluation of food flavoring substances: the role of genotoxicity studies

Sean V. Taylor, Samuel M. Cohen, S. Fukushima, 2020, Critical reviews in toxicology.

Occurrence of the NIH shift upon the cytochrome P450-catalyzed in vivo and in vitro aromatic ring hydroxylation of fluorobenzenes.

J. Vervoort, I. Rietjens, J. Koerts, 1998, Chemical research in toxicology.

Molecular orbital study of porphyrin-substrate interactions in cytochrome P450 catalysed aromatic hydroxylation of substituted anilines.

I. Rietjens, C. Veeger, M. Grodzicki, 1998, Biophysical chemistry.

Bioavailability of genistein and its glycoside genistin as measured in the portal vein of freely moving unanesthetized rats.

H. Noteborn, I. Rietjens, A. Steensma, 2006, Journal of agricultural and food chemistry.

Inability to assess the safety of zinc-enriched yeast as a source of zinc, added for nutritional purposes to foods for particular nutritional uses and foods (including food supplements) intended for the general population, based on the supporting dossiers [1]

P. Galtier, J. Larsen, D. Parent-Massin, 2009 .

Toxicity of ozone and nitrogen dioxide to alveolar macrophages: comparative study revealing differences in their mechanism of toxic action.

I. Rietjens, G. Alink, M. Gijbels, 1986, Journal of toxicology and environmental health.

Opinion on the risk for public and animal health related to the presence of sterigmatocystin in food and feed 1 EFSA Panel on Contaminants in the Food Chain ( CONTAM )

H. Knutsen, D. Schrenk, E. Dogliotti, 2013 .

Heme-(hydro)peroxide mediated O- and N-dealkylation. A study with microperoxidase.

I. Rietjens, J. Koerts, C. Veeger, 2000, European journal of biochemistry.

Members and guests of the DFG Senate Commission on Food Safety

S. Vieths, J. Hengstler, R. Vogel, 2013 .

5-Fluorouracil in colorectal cancer: rationale and clinical results of frequently used schedules.

C. Punt, I. Rietjens, Y. Kamm, 1998, Anti-cancer drugs.

Impact mechanisms of ozone at cell level

I. Rietjens, G. Alink, P. Rombout, 1989 .

Effect of modulators on 5-fluorouracil metabolite patterns in murine colon carcinoma determined by in vitro 19F nuclear magnetic resonance spectroscopy.

A. Heerschap, G. Rosenbusch, D. Wagener, 1994, Cancer research.

Scientific Opinion on the safety of heme iron (blood peptonates) for theproposed uses as a source of iron added for nutritional purposes to foods for the general population, including food supplements

P. Galtier, J. Larsen, R. Woutersen, 2010 .

Influence of polyunsaturated fatty acid supplementation and membrane fluidity on ozone and nitrogen dioxide sensitivity of rat alveolar macrophages.

I. Rietjens, G. Alink, A. Konings, 1987, Journal of toxicology and environmental health.

Opinion on mixed tocopherols, tocotrienol tocopherol and tocotrienols as sources for vitamin E added as a nutritional substance in food

C. Leclercq, W. Dekant, N. Gontard, 2008 .

Opinion of the Scientific Panel on food additives, flavourings, processing aids and materials in contact with food (AFC) on a request related to a 18th list of substances for food contact materials Question No EFSA-Q-2007-167, EFSA-Q-2006-177, EFSA-Q-2005-152, EFSA-Q-2007-022, EFSA-Q-2007-004, EFSA-

F. Toldrá, J. Larsen, C. Leclercq, 2008 .

Formation of genotoxic compounds by medium pressure ultraviolet treatment of nitrate-rich water

J. Vervoort, I. Rietjens, J. Kruithof, 2014 .

Rat liver microsomal metabolism of 2-halogenated 4-methylanilines.

J. Vervoort, I. Rietjens, B. Tyrakowska, 1992, Xenobiotica; the fate of foreign compounds in biological systems.

GRASr2 evaluation of aliphatic acyclic and alicyclic terpenoid tertiary alcohols and structurally related substances used as flavoring ingredients.

Sean V. Taylor, Christie L Harman, L. Marnett, 2014, Journal of food science.

GRAS Flavoring Substances 25. The 25th publication by the Expert Panel of the Flavor and Extract Manufacturers Association provides an update on reent progress in the consideration of flavoring ingredients generally recognized as safe under the Food Additives Amendment

Sean V. Taylor, L. Marnett, S. Fukushima, 2011 .

Calcium L-methionate, magnesium L-methionate and zinc mono-L-methionine sulphate added for nutritional purposes to food supplements - Scientific Opinion of the Panel on Food Additives and Nutrient Sources added to Food

P. Galtier, J. Larsen, D. Parent-Massin, 2009 .

GRAS 29 flavoring substances

Sean V. Taylor, Christie L Harman, S. Fukushima, 2020 .

GRAS flavoring substances 25

Robert L. Smith, Samuel Monroe Cohen, William J. Waddell, 2001 .

Scientific Opinion on the use of Gum Acacia modified with Octenyl Succinic Anhydride (OSA) as a food additive

P. Galtier, J. Larsen, R. Woutersen, 2010 .

19F NMR study on the biodegradation of fluorophenols by various Rhodococcus species

V. Bondar, J. Vervoort, I. Rietjens, 2004, Biodegradation.

Characterization of Iron(III) Tetramesitylporphyrin and Microperoxidase-8 Incorporated into the Molecular Sieve MCM-41.

I. Rietjens, Martin Piech, Kapil Bahl, 1999, Inorganic chemistry.

TRANSFORMATION OF THE INSECTICIDE TEFLUBENZURON BY MICROORGANISMS

J. Vervoort, I. Rietjens, L. Golovleva, 2001, Journal of environmental science and health. Part. B, Pesticides, food contaminants, and agricultural wastes.

Regioselectivity and reversibility of the glutathione conjugation of quercetin quinone methide.

J. Vervoort, I. Rietjens, J. Segura-Aguilar, 2000, Chemical research in toxicology.

The influence of pH on antioxidant properties and the mechanism of antioxidant action of hydroxyflavones.

I. Rietjens, I. Rietjens, H. Szymusiak, 2001, Free radical biology & medicine.

Opinion of the Scientific Panel on Food Additives, Flavourings, Processing Aids and Materials in contact with Food (AFC) on a request from the Commission

F. Toldrá, C. Leclercq, N. Gontard, 2005 .

Prooxidant toxicity of polyphenolic antioxidants to HL‐60 cells: description of quantitative structure‐activity relationships

Henryk Szymusiak, I. Rietjens, H. Szymusiak, 1999, FEBS letters.

A Quantum Mechanical/Molecular Mechanical Study of the Hydroxylation of Phenol and Halogenated Derivatives by Phenol Hydroxylase

Lars Ridder, Adrian J. Mulholland, Ivonne M. C. M. Rietjens, 2000 .

Structure-activity study on the quinone/quinone methide chemistry of flavonoids.

P. van Bladeren, J. Vervoort, I. Rietjens, 2001, Chemical research in toxicology.

Structure activity relationships for the chemical behaviour and toxicity of electrophilic quinones/quinone methides.

P. van Bladeren, J. Vervoort, I. Rietjens, 2001, Advances in experimental medicine and biology.

Peroxidase-catalyzed formation of quercetin quinone methide-glutathione adducts.

J. Vervoort, I. Rietjens, H. Awad, 2000, Archives of biochemistry and biophysics.

Levels of lead, arsenic, mercury and cadmium in clays for oral use on the Dutch market and estimation of associated risks

I. Rietjens, I. Rietjens, L. Hoogenboom, 2013, Food additives & contaminants. Part A, Chemistry, analysis, control, exposure & risk assessment.

Alkaloids in the human food chain--natural occurrence and possible adverse effects.

T. V. van Beek, I. Rietjens, B. Dusemund, 2012, Molecular nutrition & food research.

TEAC antioxidant activity of 4-hydroxybenzoates.

J. Vervoort, I. Rietjens, H. Szymusiak, 1999, Free radical biology & medicine.

Conversion of phenol derivatives to hydroxylated products by phenol hydroxylase from Trichosporon cutaneum. A comparison of regioselectivity and rate of conversion with calculated molecular orbital substrate characteristics.

J. Vervoort, I. Rietjens, I. Rietjens, 1995, European journal of biochemistry.

19F-NMR study on the pH-dependent regioselectivity and rate of the ortho-hydroxylation of 3-fluorophenol by phenol hydroxylase from Trichosporon cutaneum. Implications for the reaction mechanism.

W. van Workum, J. Vervoort, I. Rietjens, 1993, European journal of biochemistry.

Scientific Opinion on the re-evaluation of Azorubine/Carmoisine (E 122) as a food additive

P. Galtier, J. Larsen, R. Woutersen, 2009 .

Abstract of papers

E. Kroese, L. Bree, F. Zitman, 1987, Pharmaceutisch Weekblad.

The FEMA GRAS assessment of aliphatic and aromatic terpene hydrocarbons used as flavor ingredients.

L. Marnett, V. Feron, S. Cohen, 2011, Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association.

Updated opinion on a request from the European Commission related to the 2nd ERF carcinogenicity study on aspartame, taking into consideration study data submitted by the Ramazzini Foundation in February 2009

P. Galtier, J. Larsen, R. Woutersen, 2009 .

Opinion on a request from the European Commission related to the 2 nd ERF carcinogenicity study on aspartame Scientific Opinion of the Panel on Food Additives and Nutrient Sources added to Food

P. Galtier, R. Woutersen, D. Parent-Massin, 2009 .

Toxicokinetics of Bisphenol A - Scientific Opinion of the Panel on Food additives, Flavourings, Processing aids and Materials in Contact with Food (AFC).

C. Leclercq, N. Gontard, S. Barlow, 2008, EFSA journal. European Food Safety Authority.

Generation of taste through (redox)biocatalysis.

W. Berkel, I. Rietjens, C. Laane, 1997 .

Role of cytochromes P-450 and flavin-containing monooxygenase in the biotransformation of 4-fluoro-N-methylaniline.

J. Vervoort, N. Cnubben, I. Rietjens, 1993, Drug metabolism and disposition: the biological fate of chemicals.

Dependence of the conversion of chlorophenols by rhodococci on the number and position of chlorine atoms in the aromatic ring

O. V. Moiseeva, J. Vervoort, I. Rietjens, 2007, Microbiology.

Conversion of 2-Fluoromuconate to cis-Dienelactone by Purified Enzymes of Rhodococcus opacus 1cp

O. V. Moiseeva, J. Vervoort, I. Rietjens, 2003, Applied and Environmental Microbiology.

Reductive deamination as a new step in the anaerobic microbial degradation of halogenated anilines.

J. Vervoort, I. Rietjens, W. V. van Berkel, 2002, FEMS microbiology letters.

Ozone and nitrogen dioxide : a study on mechanisms of toxic action and cellular defense

I. Rietjens, 1986 .

Risks to human and animal health related to the presence of deoxynivalenol and its acetylated and modified forms in food and feed

Heather M. Wallace, H. Knutsen, H. Naegeli, 2017, EFSA journal. European Food Safety Authority.

L-selenomethionine as a source of selenium added for nutritional purposes to food supplements

P. Galtier, J. Larsen, D. Parent-Massin, 2009 .

Identification of Fluoropyrogallols as New Intermediates in Biotransformation of Monofluorophenols in Rhodococcus opacus 1cp

J. Vervoort, I. Rietjens, W. V. van Berkel, 2000, Applied and Environmental Microbiology.

Quantitative structure/activity relationship for the rate of conversion of C4-substituted catechols by catechol-1,2-dioxygenase from Pseudomonas putida (arvilla) C1.

A. Scozzafava, I. Rietjens, L. Ridder, 1998, European journal of biochemistry.

Differential substrate behaviour of phenol and aniline derivatives during conversion by horseradish peroxidase.

J. Vervoort, I. Rietjens, M. Boersma, 1999, Biochimica et biophysica acta.

19F NMR study on the biological Baeyer–Villiger oxidation of acetophenones

I. Rietjens, W. V. van Berkel, M. Moonen, 2001, Journal of Industrial Microbiology & Biotechnology.

Preferential oxidative dehalogenation upon conversion of 2-halophenols by Rhodococcus opacus 1G.

V. Bondar, J. Vervoort, I. Rietjens, 1999, FEMS microbiology letters.

19F NMR metabolomics for the elucidation of microbial degradation pathways of fluorophenols

J. Vervoort, I. Rietjens, W. V. van Berkel, 2001, Journal of Industrial Microbiology and Biotechnology.

Flavoenzyme-catalyzed oxygenations and oxidations of phenolic compounds

W. Berkel, M. Fraaije, I. Rietjens, 2002 .

Regioselectivity of cytochrome P-450 catalyzed hydroxylation of fluorobenzenes predicted by calculated frontier orbital substrate characteristics.

J. Vervoort, I. Rietjens, C. Veeger, 1993, Biochemistry.

Development of a 19F-n.m.r. method for studies on the in vivo and in vitro metabolism of 2-fluoroaniline.

J. Vervoort, I. Rietjens, P. D. de Jager, 1990, Xenobiotica; the fate of foreign compounds in biological systems.

Modelling flavin and substrate substituent effects on the activation barrier and rate of oxygen transfer by p‐hydroxybenzoate hydroxylase

J. Vervoort, I. Rietjens, B. Palfey, 2000, FEBS letters.

Combined quantum mechanical and molecular mechanical reaction pathway calculation for aromatic hydroxylation by p-hydroxybenzoate-3-hydroxylase.

A. Mulholland, J. Vervoort, I. Rietjens, 1999, Journal of molecular graphics & modelling.

Computational methods in flavin research.

J. Vervoort, I. Rietjens, H. Zuilhof, 1999, Methods in molecular biology.

Computer calculation-based quantitative structure-activity relationships for the oxidation of phenol derivatives horseradish peroxidase compound II

Sandeep Modi, Cees Veeger, Jacques Vervoort, 1996, JBIC Journal of Biological Inorganic Chemistry.

Updated procedure for the safety evaluation of natural flavor complexes used as ingredients in food.

Sean V. Taylor, F Peter Guengerich, Jeanne M. Davidsen, 2018, Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association.

Safety evaluation of substituted thiophenes used as flavoring ingredients.

Sean V. Taylor, Christie L Harman, S. Fukushima, 2017, Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association.

Bioactivation of 4-fluorinated anilines to benzoquinoneimines as primary reaction products.

J. Vervoort, I. Rietjens, 1991, Chemico-biological interactions.

Microperoxidase/H2O2-mediated alkoxylating dehalogenation of halophenol derivatives in alcoholic media.

A. Osman, I. Rietjens, C. Veeger, 1997, Proceedings of the National Academy of Sciences of the United States of America.

The influence of the peptide chain on the kinetics and stability of microperoxidases.

J. V. Van Beeumen, I. Rietjens, B. Samyn, 1996, European journal of biochemistry.

Microperoxidase/H2O2-catalyzed aromatic hydroxylation proceeds by a cytochrome-P-450-type oxygen-transfer reaction mechanism.

A. Osman, I. Rietjens, J. Koerts, 1996, European journal of biochemistry.

Cytochrome P450-mediated oxidation of pentafluorophenol to tetrafluorobenzoquinone as the primary reaction product.

P. van Bladeren, J. Vervoort, I. Rietjens, 1993, Chemical research in toxicology.

Substrate and effector specificity of two active-site mutants of p-hydroxybenzoate hydroxylase from Pseudomonas fluorescens

M. Eppink, J. Vervoort, I. Rietjens, 1994 .

The effect of varying halogen substituent patterns on the cytochrome P450 catalysed dehalogenation of 4-halogenated anilines to 4-aminophenol metabolites.

J. Vervoort, N. Cnubben, I. Rietjens, 1995, Biochemical pharmacology.

Comparative MO-QSAR studies in various species including man.

T. Wobbes, N. Cnubben, I. Rietjens, 1996, Chemico-biological interactions.

Interaction between the substrate and the high-valent-iron-oxo porphyrin cofactor as a possible factor influencing the regioselectivity of cytochrome P450 catalysed aromatic ring hydroxylation of 3-fluoro(methyl)anilines.

J. Vervoort, I. Rietjens, J. Koerts, 1996, Chemico-biological interactions.

Regioselectivity and quantitative structure-activity relationships for the conjugation of a series of fluoronitrobenzenes by purified glutathione S-transferase enzymes from rat and man.

T. Wobbes, P. van Bladeren, J. Vervoort, 1996, Chemical research in toxicology.

Quantitative structure-activity relationships based on computer calculated parameters for the overall rate of glutathione S-transferase catalyzed conjugation of a series of fluoronitrobenzenes.

G. Hooiveld, J. Vervoort, I. Rietjens, 1995, Chemical research in toxicology.

Biosynthesis and chemical determination of polyfluoro-4-hydroxyanilines

I. Rietjens, J. Koerts, S. Boeren, 2010 .

Microsomal metabolism of fluoroanilines.

J. Vervoort, I. Rietjens, 1989, Xenobiotica; the fate of foreign compounds in biological systems.

Quantitative structure activity relationships for the electron transfer reactions of Anabaena PCC 7119 ferredoxin‐NADP+ oxidoreductase with nitrobenzene and nitrobenzimidazolone derivatives: mechanistic implications

I. Rietjens, N. Čėnas, Ž. Anusevičius, 1999, FEBS letters.

Quantitative structure activity relationships for the conversion of nitrobenzimidazolones and nitrobenzimidazoles by DT‐diaphorase: implications for the kinetic mechanism

I. Rietjens, J. Segura-Aguilar, N. Čėnas, 1998, FEBS letters.

NADPH-cytochrome reductase catalysed redox cycling of 1,4-benzoquinone; hampered at physiological conditions, initiated at increased pH values.

J. Vervoort, I. Rietjens, I. Rietjens, 1994, Biochemical pharmacology.

Excretion and metabolism of desogestrel in healthy postmenopausal women

I. Rietjens, R. Vos, Frank Verheggen, 2001, The Journal of Steroid Biochemistry and Molecular Biology.

Selenium-enriched yeast as source for selenium added for nutritional purposes in foods for particular nutritional uses and foods (including food supplements) for the general population 1 Scientific Opinion of the Panel on Food Additives,

C. Leclercq, W. Dekant, N. Gontard, 2008 .

Prediction of in vivo developmental toxicity of all-trans-retinoic acid based on in vitro toxicity data and in silico physiologically based kinetic modeling

I. Rietjens, B. Blaauboer, J. Louisse, 2014, Archives of Toxicology.

Antioxidant activities of carotenoids: quantitative relationships between theoretical calculations and experimental literature data.

I. Rietjens, B. Tyrakowska, C. Laane, 1999, Free radical research.

Cytochrome P450-catalyzed oxidation of halobenzene derivatives.

P. van Bladeren, I. Rietjens, C. den Besten, 1997, Chemical research in toxicology.

Quercetin tests negative for genotoxicity in transcriptome analyses of liver and small intestine of mice.

P. Hollman, J. Keijer, E. V. van Schothorst, 2015, Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association.

Qualitative and quantitative changes in cytochrome P-450-dependent xenobiotic metabolism in pulmonary microsomes and isolated Clara cell populations derived from ozone-exposed rats.

I. Rietjens, L. van Bree, P. Rombout, 1988, Journal of toxicology and environmental health.

Conversion of pentahalogenated phenols by microperoxidase-8/H2O2 to benzoquinone-type products.

P. van Bladeren, A. Osman, I. Rietjens, 1998, Chemical research in toxicology.

Enforcement of the ban on aristolochic acids in Chinese traditional herbal preparations on the Dutch market

I. Rietjens, M. Martena, E. Konings, 2007, Analytical and bioanalytical chemistry.

Human ERa and ERb splice variants: understanding their domain structure in relation to their biological roles in breast cancer cell proliferation

J. Gustafsson, J. Vervoort, I. Rietjens, 2012 .

Human ER α and ER β Splice Variants: Understanding Their Domain Structure in Relation to Their Biological Roles in Breast Cancer Cell Proliferation

J. Gustafsson, J. Vervoort, I. Rietjens, 2012 .

Corrigendum to: ''The FEMA GRAS assessment of a,b-unsaturated aldehydes and related substances used as flavor ingredients" [Food and Chemical Toxicology 46 (2008) 2935-2967] (DOI:10.1016/j.fct.2008.06.082)

Sean V. Taylor, L. Marnett, V. Feron, 2009 .

The role of glutathione and glutathione S-transferases in fatty acid ozonide detoxification.

P. van Bladeren, I. Rietjens, G. Alink, 1987, Chemico-biological interactions.

Direct comparison of metabolic health effects of the flavonoids quercetin, hesperetin, epicatechin, apigenin and anthocyanins in high-fat-diet-fed mice

P. Hollman, J. Vervoort, J. Keijer, 2015, Genes & Nutrition.

Choline-stabilised orthosilicic acid added for nutritional purposes to food supplements

P. Galtier, J. Larsen, R. Woutersen, 2009 .

Chromium(III) lactate trihydrate as a source of chromium added fornutritional purposes to food supplements

P. Galtier, J. Larsen, R. Woutersen, 2009 .

Chromium(III)-, iron(II)- and selenium-humic acid/fulvic acid chelate andsupplemented humifulvate added for nutritional purposes to foodsupplements

P. Galtier, J. Larsen, R. Woutersen, 2009 .

Quantitative Proteomics and Transcriptomics Addressing the Estrogen Receptor Subtype-mediated Effects in T47D Breast Cancer Cells Exposed to the Phytoestrogen Genistein*

A. Ström, J. Vervoort, A. Murk, 2010, Molecular & Cellular Proteomics.

Influence of Cellular ERα/ERβ Ratio on the ERα-Agonist Induced Proliferation of Human T47D Breast Cancer Cells

J. Gustafsson, A. Ström, J. Vervoort, 2008, Toxicological sciences : an official journal of the Society of Toxicology.

Molecular dynamics and in vitro quantification of safrole DNA adducts reveal DNA adduct persistence due to limited DNA distortion resulting in inefficient repair.

C. Oostenbrink, J. Vervoort, I. Rietjens, 2020, Chemical research in toxicology.

Influence of Cellular ER a / ER b Ratio on the ER a-Agonist Induced Proliferation of Human T 47 D Breast Cancer Cells

J. Gustafsson, A. Ström, J. Vervoort, 2008 .

Kinetics of cytochromes P-450 IA1 and IIB1 in reconstituted systems with dilauroyl- and distearoyl-glycerophosphocholine.

I. Rietjens, C. Veeger, M. Boersma, 1993, European journal of biochemistry.

On the role of phospholipids in the reconstituted cytochrome P-450 system. A model study using dilauroyl and distearoyl glycerophosphocholine.

I. Rietjens, C. Veeger, L. J. Ancher, 1989, European journal of biochemistry.

GRAS 28 flavoring substances

Sean V. Taylor, Christie L Harman, S. Fukushima, 2018 .

Cellular levels and molecular dynamics simulations of estragole DNA adducts point at inefficient repair resulting from limited distortion of the double-stranded DNA helix

C. Oostenbrink, J. Vervoort, I. Rietjens, 2020, Archives of Toxicology.

Scientific Opinion on the re-evaluation of Brown FK (E 154) as a foodadditive

P. Galtier, J. Larsen, R. Woutersen, 2010 .

The use of adverse outcome pathways in the safety evaluation of food additives

Timothy E. H. Allen, M. Vinken, A. Boobis, 2020, Archives of Toxicology.

The food colour Red 2G (E128)

F. Toldrá, C. Leclercq, W. Dekant, 2007 .

Use of molecular orbital calculations in studies on mechanisms of enzyme catalysis.

W. Berkel, J. Vervoort, N. Cnubben, 1994 .

A theoretical approach of the mechanism of C(4a)-peroxyflavin catalyzed reactions.

J. Vervoort, I. Rietjens, J. Lee, 1994 .

Biocatalytic Potential of p-Hydroxybenzoate Hydroxylase from Rhodococcus rhodnii 135 and Rhodococcus opacus 557

W. Berkel, I. Rietjens, L. Golovleva, 2004 .

GSTP1‐1 stereospecifically catalyzes glutathione conjugation of ethacrynic acid

P. van Bladeren, M. V. van Lipzig, J. Vervoort, 1998, FEBS letters.

Scientific Opinion on the use of calcium lignosulphonate (40-65) as a carrier for vitamins and carotenoids

P. Galtier, J. Larsen, R. Woutersen, 2010 .

Flavouring Group Evaluation 6, Revision 1 (FGE.06Rev1): Straight- and branched-chain aliphatic unsaturated primary alcohols, aldehydes, carboxylic acids, and esters from chemical groups 1 and 4

F. Toldrá, C. Leclercq, N. Gontard, 2008 .

[Plant-derived contaminants in food : Occurrence, effects and risk assessment].

A. Lampen, I. Rietjens, B. Dusemund, 2017, Bundesgesundheitsblatt, Gesundheitsforschung, Gesundheitsschutz.

The effect of iron to manganese substitution on microperoxidase 8 catalysed peroxidase and cytochrome P450 type of catalysis

I. Rietjens, C. Veeger, S. Boeren, 1999, JBIC Journal of Biological Inorganic Chemistry.

Molecular orbital-based quantitative structure-activity relationship for the cytochrome P450-catalyzed 4-hydroxylation of halogenated anilines.

J. Vervoort, N. Cnubben, I. Rietjens, 1994, Chemical research in toxicology.

Reversible formation of high-valent-iron-oxo-porphyrin intermediate in heme-based catalysis: revisiting the kinetic model for horseradish peroxidase

A. Osman, I. Rietjens, C. Veeger, 1998 .

On the role of the axial ligand in heme-based catalysis of the peroxidase and P450 type

Cees Veeger, J. Antony, A. Osman, 1996, JBIC Journal of Biological Inorganic Chemistry.

Molecular orbital study of the hydroxylation of benzene and monofluorobenzene catalysed by iron-oxo porphyrin π cation radical complexes

Ivonne M. C. M. Rietjens, Cees Veeger, I. Rietjens, 1996, JBIC Journal of Biological Inorganic Chemistry.

Differential cumene hydroperoxide sensitivity of cytochrome P-450 enzymes IA1 and IIB1 determined by their way of membrane incorporation.

I. Rietjens, C. Veeger, M. Boersma, 1992, Biochimica et biophysica acta.

[Fluorene degradation by bacteria of the genus Rhodococcus].

J. Vervoort, I. Rietjens, L. Golovleva, 2003, Mikrobiologiia.

Quercetin Induces Hepatic Lipid Omega-Oxidation and Lowers Serum Lipid Levels in Mice

P. Hollman, J. Vervoort, J. Keijer, 2013, PloS one.

Flavouring Group Evaluation 49, (FGE. 49): Xanthin alkaloids from the Priority list from chemical group 30 Scientific Opinion of the Panel on Food Additives, Flavourings, Processing Aids and Materials in Contact with Food

F. Toldrá, J. Larsen, C. Leclercq, 2009 .

Data requirements for the evaluation of food additive applications [1]

Paul Tobback, Fernando Aguilar, Ivan Stankovic, 2009 .

Opinion on Pyridoxal 5'-phosphate as a source for vitamin B6 added for nutritional purposes in food supplements 1 Scientific Panel on Food Additives, Flavourings, Processing Aids and Materials in Contact with Food

C. Leclercq, W. Dekant, N. Gontard, 2008 .

Chemical hazards in foods of animal origin and the associated risks for public health: elementary considerations

F. Smulders, I. Rietjens, M. Rose, 2019, Chemical hazards in foods of animal origin.

Biochemical and morphological changes in lung tissue and isolated lung cells of rats induced by short-term nitrogen dioxide exposure

I. Rietjens, G. Alink, L. van Bree, 2000, Human & experimental toxicology.

Orotic acid salts as sources of orotic acid and various minerals added for nutritional purposes to food supplements

P. Galtier, D., R., 2009 .

Iron (II) taurate, magnesium taurate and magnesium acetyl taurateas sources of iron or magnesium added for nutritional purposes infood supplements

P. Galtier, J. Larsen, R. Woutersen, 2009 .

Flavouring Group Evaluation 2, Revision 1: Branched- and straight-chain aliphatic saturated primary alcohols and related esters of primary alcohols and straight-chain carboxylic acids and one straight-chain aldehyde from chemical

C. Leclercq, N. Gontard, S. Barlow, 2008 .

Opinion of the Scientific Panel on Food Additives, Flavourings, Processing Aids and Materials in Contact with Foodon a request from the Commission related to an applicationon the use of cassia gum as a food additive

F. Toldrá, C. Leclercq, W. Dekant, 2006 .

Food Additives , Flavourings , Processing Aids and Materials in Contact with Food ( Question No EFSA-Q-2003-137 ) Adopted on 27 September 2007 PANEL MEMBERS

F. Toldrá, C. Leclercq, W. Dekant, 2007 .

Opinion of the Scientific Panel on food additives, flavourings, processing aids and materials in contact with food (AFC) related to a 8th list of substances for food contact materials

F. Toldrá, C. Leclercq, W. Dekant, 2005 .

Characterization of different commercial soybean peroxidase preparations and use of the enzyme for N-demethylation of methyl N-methylanthranilate To produce the food flavor methylanthranilate.

I. Rietjens, H. Weenen, C. Laane, 2000, Journal of agricultural and food chemistry.

Monomethylsilanetriol added for nutritional purposes to food supplements

P. Galtier, J. Larsen, D. Parent-Massin, 2009 .

Chemical hazards in foods of animal origin

F. Smulders, I. Rietjens, Rose, 2019, ECVPH Food safety assurance.

Predictive Models for the Efficacy of Bioremediation

A. Scozzafava, I. Rietjens, B. Tyrakowska, 1997 .

Fluorene Transformation by Bacteria of the Genus Rhodococcus

J. Vervoort, I. Rietjens, L. Golovleva, 2003, Microbiology.

Opinion of the Scientific Panel on food additives, flavourings, processing aids and materials in contact with food (AFC) related to use of an enzyme preparation based on thrombin:fibrinogen derived from cattle and/or pigs as a food additive for reconstituting food

F. Toldrá, C. Leclercq, W. Dekant, 2005 .

A specific interaction between NADPH-cytochrome reductase and phosphatidylserine and phosphatidylinositol.

J. Vervoort, I. Rietjens, A. Ouwehand, 1993, European journal of biochemistry.

Sodium monofluorophosphate as a source of fluoride added for nutritional purposes to food supplements 1 Scientific Opinion of the Panel on Food Additives and Nutrient Sources added to Food

P. Galtier, R. Woutersen, P. Tobback, 2008 .

Quercetin decreases high-fat diet induced body weight gain and accumulation of hepatic and circulating lipids in mice

P. Hollman, J. Vervoort, J. Keijer, 2014, Genes & Nutrition.

5-Fluorouracil metabolite patterns in viable and necrotic tumor areas of murine colon carcinoma determined by in vitro 19F NMR spectroscopy.

A. Heerschap, G. Rosenbusch, J. Vervoort, 1996 .

Influence of Cellular ERα/ERβ Ratio on the ERα-Agonist Induced Proliferation of Human T47D Breast Cancer Cells

J. Gustafsson, A. Ström, J. Vervoort, 2008, Toxicological sciences : an official journal of the Society of Toxicology.

Ab initio QM/MM modeling of the hydroxylation step in p-hydroxybenzoate hydroxylase

Lars Ridder, Jeremy N. Harvey, Adrian J. Mulholland, 2003 .

Safety assessment of plant food supplements (PFS).

L. Serra-Majem, P. Coppens, I. Rietjens, 2011, Food & function.

Molecular determinants of xenobiotic metabolism: QM/MM simulation of the conversion of 1-chloro-2,4-dinitrobenzene catalyzed by M1-1 glutathione S-transferase.

Lars Ridder, Adrian J Mulholland, Anna L. Bowman, 2007, Biochemistry.

Quantum mechanical/molecular mechanical free energy simulations of the glutathione S-transferase (M1-1) reaction with phenanthrene 9,10-oxide.

Lars Ridder, Adrian J Mulholland, Ivonne M C M Rietjens, 2002, Journal of the American Chemical Society.

CORRELATION OF CALCULATED ACTIVATION ENERGIES WITH EXPERIMENTAL RATE CONSTANTS FOR AN ENZYME CATALYZED AROMATIC HYDROXYLATION

A. Mulholland, J. Vervoort, I. Rietjens, 1998 .

Statistical Significance and Biological Relevance Efsa Scientific Committee Background as Provided by Efsa Terms of Reference as Provided by Efsa

A. Chesson, H. Kuiper, B. Nørrung, 2011 .

Ozone and nitrogen dioxide : a study on mechanisms of toxic action and cellular defense

I. Rietjens, 1986 .