B. Hakkert

发表

International regulatory needs for development of an IATA for non-genotoxic carcinogenic chemical substances.

Martin Paparella, Mirjam Luijten, Kimmo Louekari, 2016, ALTEX.

Nanomaterials under REACH

R. Luttik, B. Hakkert, R. Luttik, 2009 .

Extrapolation for Exposure Duration in Oral Toxicity: A Quantitative Analysis of Historical Toxicity Data

B. Hakkert, P. Bos, C. N. Groeneveld, 2004 .

Assessment factors for human health risk assessment: a discussion paper.

W Slob, T Vermeire, H Stevenson, 1999, Critical reviews in toxicology.

Comparison of chemical-induced transcriptional activation of fish and human estrogen receptors: regulatory implications.

Weiqi Wang, T. Vermeire, B. Hakkert, 2011, Toxicology letters.

Why Do Countries Regulate Environmental Health Risks Differently? A Theoretical Perspective

E. Lebret, A. Piersma, T. Vermeire, 2018, Risk analysis : an official publication of the Society for Risk Analysis.

Finding maximal transcriptome differences between reprotoxic and non‐reprotoxic phthalate responses in rat testis

A. Verhoef, T. Breit, M. Jonker, 2011, Journal of applied toxicology : JAT.

Role of endothelial leukocyte adhesion molecule-1 and platelet-activating factor in neutrophil adherence to IL-1-prestimulated endothelial cells. Endothelial leukocyte adhesion molecule-1-mediated CD18 activation.

T. Kuijpers, J. Leeuwenberg, B. Hakkert, 1991, Journal of immunology.

Neutrophil and monocyte adherence to and migration across monolayers of cytokine-activated endothelial cells: the contribution of CD18, ELAM-1, and VLA-4.

T. Kuijpers, J. V. van Mourik, J. Leeuwenberg, 1991, Blood.

Monocytes enhance endothelial von Willebrand factor release and prostacyclin production with different kinetics and dependency on intercellular contact between these two cell types

J. V. van Mourik, B. Hakkert, J. Rentenaar, 1992, British journal of haematology.

Cytokine-prestimulated Endothelial Cells: A RoleforPlateletActivating Factor and IL-8

T. Kuijpers, M. Hart, B. Hakkert, 1992 .

Membrane surface antigen expression on human monocytes: changes during purification, in vitro activation and transmigration across monolayers of endothelial cells

T. Kuijpers, E. Knol, B. Hakkert, 1992 .

Neutrophil migration across monolayers of cytokine-prestimulated endothelial cells: a role for platelet-activating factor and IL-8

T. Kuijpers, M. Hart, B. Hakkert, 1992, The Journal of cell biology.

A three‐dimensional model system to study the interactions between human leukocytes and endothelial cells

J. V. van Mourik, B. Hakkert, D. Roos, 1990, European journal of immunology.

CD18, ELAM-1, and VLA-4 of monolayers of cytokine-activated endothelial cells: the contribution Neutrophil and monocyte adherence to and migration across

T. Kuijpers, J. Leeuwenberg, B. Hakkert, 2011 .

Involvement of ELAM-1 in monocyte adherence to and migration across IL-1-stimulated endothelial cell monolayers

T. Kuijpers, W. Buurman, B. Hakkert, 1992 .

Rebuttal to the letters to the editors by Terry et al. and Sewell et al. regarding Heringa et al. (2020).

W. Slob, N. Cnubben, M. Woutersen, 2020, Regulatory toxicology and pharmacology : RTP.

Comparative in vitro-in vivo percutaneous absorption of the pesticide propoxur.

J. J. van de Sandt, N. Cnubben, B. Hakkert, 2000, Toxicological sciences : an official journal of the Society of Toxicology.

An integrative test strategy for cancer hazard identification

Mirjam Luijten, Emiel Rorije, Jan van Benthem, 2016, Critical reviews in toxicology.

A retrospective analysis of developmental toxicity studies in rat and rabbit: what is the added value of the rabbit as an additional test species?

Wout Slob, Aldert H Piersma, Gemma Janer, 2008, Regulatory toxicology and pharmacology : RTP.

Monocytes enhance the bidirectional release of type I plasminogen activator inhibitor by endothelial cells.

J. V. van Mourik, B. Hakkert, J. Rentenaar, 1990, Blood.

TOXICOLOGICAL HIGHLIGHT Assessing Dermal Absorption

N. Cnubben, B. Hakkert, G. Elliott, 2000 .

Quantitative in vitro - in vivo extrapolation

G. Wolterink, J. Bessems, B. Hakkert, 2008 .

Quantitative extrapolation of in vitro whole embryo culture embryotoxicity data to developmental toxicity in vivo using the benchmark dose approach.

Wout Slob, Aldert H Piersma, Gemma Janer, 2008, Toxicological sciences : an official journal of the Society of Toxicology.

Comparative in vitro-in vivo percutaneous penetration of the fungicide ortho-phenylphenol.

J. J. van de Sandt, N. Cnubben, B. Hakkert, 2002, Regulatory toxicology and pharmacology : RTP.

Use of the kinetically-derived maximum dose concept in selection of top doses for toxicity studies hampers proper hazard assessment and risk management.

Marjolijn Woutersen, Marja E J Pronk, Betty C Hakkert, 2020, Regulatory toxicology and pharmacology : RTP.

Regulating human safety: How dose selection in toxicity studies impacts human health hazard assessment and subsequent risk management options.

N. Cnubben, M. Woutersen, B. Hakkert, 2020, Regulatory toxicology and pharmacology : RTP.

New approach methodologies (NAMs) for human-relevant biokinetics predictions: Meeting the paradigm shift in toxicology towards an animal-free chemical risk assessment.

Bas J Blaauboer, Alicia Paini, Paul Jennings, 2020, ALTEX.

Genotoxicity testing of cigarette-smoke condensate in the SCE and HGPRT assays with V79 Chinese hamster cells.

W. Jongen, B. Hakkert, J. C. van der Hoeven, 1985, Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association.

Combined retrospective analysis of 498 rat multi-generation reproductive toxicity studies: on the impact of parameters related to F1 mating and F2 offspring.

E Rorije, A H Piersma, D J Dix, 2011, Reproductive toxicology.

Digestibility of dietary proteins and serum cholesterol in rats.

B. Hakkert, A. Beynen, C. West, 1987 .

Nanomaterials under REACH. Nanosilver as a case study

Sir, Bleeker Eaj, Wijnhoven Swp, 2009 .

A retrospective analysis of the two-generation study: what is the added value of the second generation?

Wout Slob, Aldert H Piersma, Gemma Janer, 2007, Reproductive toxicology.

Distinct adhesive properties of granulocytes and monocytes to endothelial cells under static and stirred conditions.

T. Kuijpers, J. V. van Mourik, B. Hakkert, 1990, Journal of immunology.

Do current EU regulations for the safety assessment of chemical substances pose legal barriers for the use of alternatives to animal testing

B. Hakkert, M. Heringa, P. Bos, 2015 .

Retrospective analysis of relative parameter sensitivity in multi-generation reproductive toxicity studies.

A. Piersma, B. Hakkert, E. Rorije, 2009, Reproductive toxicology.

A retrospective analysis of the added value of the rat two-generation reproductive toxicity study versus the rat subchronic toxicity study.

Wout Slob, Aldert H Piersma, Gemma Janer, 2007, Reproductive toxicology.

Does REACH provide sufficient information to regulate mutagenic and carcinogenic substances?

Marjolijn Woutersen, Martijn Beekman, Marja E. J. Pronk, 2018, Human and Ecological Risk Assessment: An International Journal.

On the impact of second generation mating and offspring in multi-generation reproductive toxicity studies on classification and labelling of substances in Europe.

Martin Paparella, Barbara Heinrich-Hirsch, Aldert H Piersma, 2011, Regulatory toxicology and pharmacology : RTP.

Inhibitory effects of the phorbolester TPA and cigarette smoke condensate on the mutagenicity of benzo[a]pyrene in a co-cultivation system.

W. Jongen, B. Hakkert, M. V. D. van de Poll, 1986, Mutation research.

Endpoint sensitivity in fish endocrine disruption assays: regulatory implications.

T. Vermeire, B. Hakkert, H. Yin, 2011, Toxicology letters.