A. Farce

发表

Docking study: PPARs interaction with the selected alternative plasticizers to di(2-ethylhexyl) phthalate

P. Chavatte, M. Luyckx, N. Kambia, 2015, Journal of enzyme inhibition and medicinal chemistry.

Toward the Discovery of a Novel Class of YAP–TEAD Interaction Inhibitors by Virtual Screening Approach Targeting YAP–TEAD Protein–Protein Interface

G. Huet, X. Thuru, P. Chavatte, 2018, Cancers.

Novel indolizine derivatives with unprecedented inhibitory activity on human farnesyltransferase.

A. Farce, Dalila Belei, E. Bîcu, 2014, Bioorganic & medicinal chemistry letters.

Synthesis and biological evaluation of thiophene and benzo[b]thiophene analogs of combretastatin A-4 and isocombretastatin A-4: A comparison between the linkage positions of the 3,4,5-trimethoxystyrene unit.

O. Berthier‐Vergnes, A. Farce, M. Fauvarque, 2016, Bioorganic & medicinal chemistry letters.

Discovery of ferrocene-containing farnesyltransferase inhibitors. Investigation of bulky lipophilic groups for the A2 binding site of farnesyltransferase

A. Farce, P. Gautret, J. Hénichart, 2012 .

Peptide chemistry applied to a new family of phenothiazine-containing inhibitors of human farnesyltransferase.

A. Farce, Dalila Belei, E. Bîcu, 2014, Bioorganic & medicinal chemistry letters.

Synthesis and biological evaluation of a new series of N-ylides as protein farnesyltransferase inhibitors.

A. Farce, E. Bîcu, J. Dubois, 2013, Bioorganic & medicinal chemistry letters.

Design, synthesis and biological evaluation of substituted dioxodibenzothiazepines and dibenzocycloheptanes as farnesyltransferase inhibitors.

A. Lemoine, G. Laconde, A. Farce, 2007, Bioorganic & medicinal chemistry letters.

Three-Dimensional Quantitative Structure–Activity Relationship of MT3 Melatonin Binding Site Ligands: A Comparative Molecular Field Analysis

J. Boutin, P. Renard, P. Chavatte, 2007 .

Synthesis and biological evaluation of fluoro analogues of antimitotic phenstatin.

A. Farce, P. Gautret, J. Dubois, 2013, Bioorganic & medicinal chemistry.

Synthesis and anticancer activity of analogues of phenstatin, with a phenothiazine A-ring, as a new class of microtubule-targeting agents.

A. Farce, P. Gautret, Dalila Belei, 2013, Bioorganic & medicinal chemistry letters.

On the synthesis and biological properties of isocombretastatins: a case of ketone homologation during Wittig reaction attempts

A. Farce, P. Gautret, C. Waterlot, 2013 .

Polycyclic nitrogen heterocycles as potential thymidine phosphorylase inhibitors: synthesis, biological evaluation, and molecular docking study

M. Sari, P. Chavatte, A. Farce, 2021, Journal of enzyme inhibition and medicinal chemistry.

Anti-diabetic activity of fused PPARγ-SIRT1 ligands with limited body-weight gain by mimicking calorie restriction and decreasing SGK1 expression.

A. Ktorza, B. Staels, A. Farce, 2017, European journal of medicinal chemistry.

Synthesis and biological evaluation of a new series of phenothiazine-containing protein farnesyltransferase inhibitors.

A. Farce, P. Gautret, Dalila Belei, 2013, European journal of medicinal chemistry.

Synthesis and biological evaluation of new phenothiazine derivatives bearing a pyrazole unit as protein farnesyltransferase inhibitors.

A. Farce, Dalila Belei, E. Bîcu, 2012, Bioorganic & medicinal chemistry letters.

Intestinal antiinﬂammatory effect of 5-aminosalicylic acid is dependent on peroxisome proliferator–activated receptor- (cid:1)

J. Auwerx, W. Wahli, P. Chavatte, 2005 .

Synthesis and biological evaluation of ferrocene-based cannabinoid receptor 2 ligands.

A. Farce, S. Coles, G. Tizzard, 2018, Future medicinal chemistry.

Docking Study of Ligands into the Colchicine Binding Site of Tubulin

D. Lesieur, P. Chavatte, A. Farce, 2004, Journal of enzyme inhibition and medicinal chemistry.

Comparative Effects of Di-(2-ethylhexyl)phthalate and Di-(2-ethylhexyl)terephthalate Metabolites on Thyroid Receptors: In Vitro and In Silico Studies

M. Chagnon, V. Sautou, E. Moreau, 2021, Metabolites.

Functional genomics uncovers the transcription factor BNC2 as required for myofibroblastic activation in fibrosis

J. Eeckhoute, F. Pattou, S. Cianférani, 2022, Nature Communications.

Switching invariant natural killer T (iNKT) cell response from anticancerous to anti-inflammatory effect: molecular bases.

P. Chavatte, B. Bertin, P. Desreumaux, 2014, Journal of medicinal chemistry.

Phenothiazine-based CaaX competitive inhibitors of human farnesyltransferase bearing a cysteine, methionine, serine or valine moiety as a new family of antitumoral compounds.

A. Farce, Dalila Belei, E. Bîcu, 2015, Bioorganic & medicinal chemistry letters.

Synthesis, biological evaluation and docking studies of 4-amino-tetrahydroquinazolino[3,2-e]purine derivatives.

B. Pfeiffer, A. Farce, S. Léonce, 2010, European journal of medicinal chemistry.

In vitro and in silico approach to study the hormonal activities of the alternative plasticizer tri-(2-ethylhexyl) trimellitate TEHTM and its metabolites

M. Chagnon, V. Sautou, E. Moreau, 2022, Archives of Toxicology.

New indolizine-chalcones as potent inhibitors of human farnesyltransferase: Design, synthesis and biological evaluation.

A. Farce, Dalila Belei, E. Bîcu, 2016, Bioorganic & medicinal chemistry letters.

Quinazoline-urea, new protein kinase inhibitors in treatment of prostate cancer

P. Depreux, A. Lemoine, A. Farce, 2010, Journal of enzyme inhibition and medicinal chemistry.

Effect of Oxime Ether Incorporation in Acyl Indole Derivatives on PPAR Subtype Selectivity

J. Boutin, A. Ktorza, B. Staels, 2012, ChemMedChem.

New piperazine multi-effect drugs prevent neurofibrillary degeneration and amyloid deposition, and preserve memory in animal models of Alzheimer's disease

L. Buée, N. Sergeant, V. Vingtdeux, 2019, Neurobiology of Disease.

Indolizine-phenothiazine hybrids as the first dual inhibitors of tubulin polymerization and farnesyltransferase with synergistic antitumor activity.

A. Farce, E. Bîcu, J. Dubois, 2020, Bioorganic chemistry.

Ultrasounds-mediated 10-seconds synthesis of chalcones as potential farnesyltransferase inhibitors.

A. Farce, J. Dubois, Alina Ghinet, 2020, Bioorganic & medicinal chemistry letters.

On the discovery of new potent human farnesyltransferase inhibitors: emerging pyroglutamic derivatives.

A. Farce, J. Dubois, Alina Ghinet, 2017, Organic & biomolecular chemistry.

New farnesyltransferase inhibitors in the phenothiazine series.

A. Farce, Dalila Belei, E. Bîcu, 2012, Bioorganic & medicinal chemistry letters.

Synthesis and structure-activity relationships of (aryloxy)quinazoline ureas as novel, potent, and selective vascular endothelial growth factor receptor-2 inhibitors.

P. Depreux, P. Chavatte, A. Lemoine, 2012, Journal of medicinal chemistry.

Studies on indolizines. Evaluation of their biological properties as microtubule-interacting agents and as melanoma targeting compounds.

A. Farce, P. Gautret, Dalila Belei, 2015, European journal of medicinal chemistry.

Derivatives of Iressa, a Specific Epidermal Growth Factor Receptor Inhibitor, are Powerful Apoptosis Inducers in PC3 Prostatic Cancer Cells

P. Depreux, A. Lemoine, G. Laconde, 2007, ChemMedChem.

Synthesis of a novel conformationally restricted Val‐Phe dipeptidomimetic

A. Farce, R. Houssin, J. Hénichart, 2006, Journal of peptide science : an official publication of the European Peptide Society.

Novel 1,3-dicarbonyl compounds having 2(3H)-benzazolonic heterocycles as PPARgamma agonists.

J. Boutin, D. Lesieur, P. Renard, 2006, Bioorganic & medicinal chemistry.

Quantitative structure-activity relationships studies of antioxidant hexahydropyridoindoles and flavonoid derivatives

P. Chavatte, A. Farce, S. Dilly, 2007, Journal of enzyme inhibition and medicinal chemistry.

Relationships between Th1 or Th2 iNKT Cell Activity and Structures of CD1d-Antigen Complexes: Meta-analysis of CD1d-Glycolipids Dynamics Simulations

Philippe Chavatte, Eric Henon, Xavier Laurent, 2014, PLoS Comput. Biol..

NMR studies of interactions of new CB2 cannabinoid receptor ligands with cyclodextrins hosts. Correlation with micellar electrokinetic chromatography and reversed phase high performance liquid chromatography

P. Chavatte, A. Farce, C. Vaccher, 2014, Journal of Inclusion Phenomena and Macrocyclic Chemistry.

Combretastatin A-4 sulfur-containing heterocyclic derivatives: Synthesis, antiproliferative activities and molecular docking studies.

J. Preto, A. Farce, M. Fauvarque, 2021, European journal of medicinal chemistry.

Potent farnesyltransferase inhibitors with 1,4-diazepane scaffolds as novel destabilizing microtubule agents in hormone-resistant prostate cancer.

P. Chavatte, A. Lemoine, A. Farce, 2011, Journal of medicinal chemistry.

New farnesyltransferase inhibitors in the phenothiazine series.

A. Farce, Dalila Belei, E. Bîcu, 2012, Bioorganic & medicinal chemistry letters.

Solid-phase synthesis and pharmacological evaluation of a library of peptidomimetics as potential farnesyltransferase inhibitors: an approach to new lead compounds.

P. Chavatte, A. Lemoine, A. Farce, 2006, European journal of medicinal chemistry.

Targeting peroxisome proliferator-activated receptors (PPARs): development of modulators.

Philippe Chavatte, Pierre Desreumaux, Nicolas Renault, 2012, Journal of medicinal chemistry.

Novel 4-oxo-1,4-dihydroquinoline-3-carboxamide derivatives as new CB2 cannabinoid receptors agonists: synthesis, pharmacological properties and molecular modeling.

Philippe Chavatte, Amaury Farce, P. Depreux, 2006, Journal of medicinal chemistry.

Exploring isoxazoles and pyrrolidinones decorated with the 4,6‐dimethoxy‐1,3,5‐triazine unit as human farnesyltransferase inhibitors

X. Thuru, A. Farce, Dalila Belei, 2019, Archiv der Pharmazie.

[4-(6,7-Disubstituted quinazolin-4-ylamino)phenyl] carbamic acid esters: a novel series of dual EGFR/VEGFR-2 tyrosine kinase inhibitors

P. Depreux, A. Lemoine, A. Farce, 2011 .

Differences in Binding Sites of Two Melatonin Receptors Help to Explain Their Selectivity to Some Melatonin Analogs: A Molecular Modeling Study

P. Chavatte, R. Efremov, A. Farce, 2006, Journal of biomolecular structure & dynamics.

Intestinal antiinflammatory effect of 5-aminosalicylic acid is dependent on peroxisome proliferator–activated receptor-γ

J. Auwerx, W. Wahli, D. Metzger, 2005, The Journal of experimental medicine.

Design and synthesis of naphthalenic derivatives as new ligands at the melatonin binding site MT3.

J. Boutin, P. Renard, P. Delagrange, 2011, European journal of medicinal chemistry.

Impact of aryloxy-linked quinazolines: a novel series of selective VEGFR-2 receptor tyrosine kinase inhibitors.

P. Depreux, A. Lemoine, A. Farce, 2011, Bioorganic & medicinal chemistry letters.

Structural Insight into PPAR? Ligands Binding

P. Chavatte, A. Farce, N. Renault, 2009 .

Pyroglutamide-Based P2X7 Receptor Antagonists Targeting Inflammatory Bowel Disease.

A. Farce, S. Adriouch, B. Sendid, 2020, Journal of medicinal chemistry.

Enhanced antitumor potential induced by chloroacetate-loaded benzophenones acting as fused tubulin-pyruvate dehydrogenase kinase 1 (PDHK1) ligands.

X. Thuru, A. Farce, J. Dubois, 2020, Bioorganic chemistry.

Methylene versus carbonyl bridge in the structure of new tubulin polymerization inhibitors with tricyclic A-rings.

A. Farce, E. Bîcu, J. Dubois, 2016, Bioorganic & medicinal chemistry.

Studies on phenothiazines: New microtubule-interacting compounds with phenothiazine A-ring as potent antineoplastic agents.

A. Farce, E. Bîcu, J. Dubois, 2016, Bioorganic & medicinal chemistry.

Homology modeling of MT1 and MT2 receptors.

G. Vergoten, D. Lesieur, P. Chavatte, 2008, European journal of medicinal chemistry.

Virtual Screening of CB2 Receptor Agonists from Bayesian Network and High‐Throughput Docking: Structural Insights into Agonist‐Modulated GPCR Features

Philippe Chavatte, Pierre Desreumaux, Xavier Laurent, 2013, Chemical biology & drug design.

Homology Modeling of 5-HT2C Receptors

Philippe Chavatte, Nicolas Renault, Amaury Farce, 2011 .

In vitro and in silico hormonal activity studies of di‐(2‐ethylhexyl)terephthalate, a di‐(2‐ethylhexyl)phthalate substitute used in medical devices, and its metabolites

M. Chagnon, V. Sautou, E. Moreau, 2019, Journal of applied toxicology : JAT.

2,6-Diphenylthiazolo[3,2-b][1,2,4]triazoles as telomeric G-quadruplex stabilizers.

P. Chavatte, J. Mergny, P. Roussel, 2009, Bioorganic & medicinal chemistry letters.

SINAPs: A Software Tool for Analysis and Visualization of Interaction Networks of Molecular Dynamics Simulations

P. Chavatte, A. Farce, A. Lachgar, 2022, J. Chem. Inf. Model..

Novel structural insights for drug design of selective 5-HT(2C) inverse agonists from a ligand-biased receptor model.

P. Chavatte, A. Farce, N. Renault, 2010, European journal of medicinal chemistry.

Synthesis, antiproliferative activity and tubulin targeting effect of acridinone and dioxophenothiazine derivatives.

A. Lemoine, M. Lecoeur, A. Farce, 2013, European journal of medicinal chemistry.

Characterization of GEXP15 as a Potential Regulator of Protein Phosphatase 1 in Plasmodium falciparum

I. Guerrera, A. Farce, A. Cabezas-Cruz, 2023, bioRxiv.

Molecular modelling of phthalates – PPARs interactions

P. Chavatte, M. Luyckx, N. Kambia, 2008, Journal of enzyme inhibition and medicinal chemistry.

Phenothiazine- and Carbazole-Cyanochalcones as Dual Inhibitors of Tubulin Polymerization and Human Farnesyltransferase

A. Farce, E. Bîcu, J. Dubois, 2023, Pharmaceuticals.

Antioxidant activity of new benzo[de]quinolines and lactams: 2D-quantitative structure-activity relationships.

A. Farce, P. Gautret, J. Pommery, 2012, Medicinal chemistry.

Chlorinated and brominated bisphenol A derivatives: Synthesis, characterization and determination in water samples.

P. Chavatte, V. Migeot, A. Farce, 2018, Chemosphere.

Characterization of the Plasmodium berghei regulatory AAA-ATPase subunit Rpt3 as an activator of Protein Phosphatase 1: direct and indirect evidence

A. Martoriati, K. Cailliau, I. Guerrera, 2023, bioRxiv.

Identification of a pharmacophore of SKCa channel blockers

P. Chavatte, A. Farce, S. Dilly, 2005, Journal of enzyme inhibition and medicinal chemistry.

Structural insight into PPARgamma ligands binding.

P. Chavatte, A. Farce, N. Renault, 2009, Current Medicinal Chemistry.

Genetic polymorphism of CYP4A11 and CYP4A22 genes and in silico insights from comparative 3D modelling in a French population.

P. Chavatte, C. L. Lino Cardenas, J. Lo-Guidice, 2011, Gene.

Effect of Oxime Ether Incorporation in Acyl Indole Derivatives on PPAR Subtype Selectivity

J. Boutin, A. Ktorza, B. Staels, 2012, ChemMedChem.

Peptide chemistry applied to a new family of phenothiazine-containing inhibitors of human farnesyltransferase.

A. Farce, Dalila Belei, E. Bîcu, 2014, Bioorganic & medicinal chemistry letters.

Distinct binding hotspots for natural and synthetic agonists of FFA4 from in silico approaches.

A. Farce, Corentin Bedart, Guillaume Patient, 2024, Molecular informatics.

Deciphering the mechanisms involved in reduced sensitivity to azoles and fengycin lipopeptide in Venturia inaequalis.

A. Farce, F. Laruelle, A. Lounès-Hadj Sahraoui, 2024, Microbiological research.