S. Shukla

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Improving cancer chemotherapy with modulators of ABC drug transporters.

S. Ambudkar, S. Shukla, S. Ohnuma, 2011, Current drug targets.

The linker region of breast cancer resistance protein ABCG2 is critical for coupling of ATP-dependent drug transport

S. Bates, R. Robey, S. Ambudkar, 2016, Cellular and Molecular Life Sciences.

Synthesis and biological evaluation of analogues of the kinase inhibitor nilotinib as Abl and Kit inhibitors.

Xin Hu, Suneet Shukla, Damien Y. Duveau, 2013, Bioorganic & medicinal chemistry letters.

Bioluminescent imaging of drug efflux at the blood–brain barrier mediated by the transporter ABCG2

Bih-Rong Wei, R. M. Simpson, M. Gottesman, 2013, Proceedings of the National Academy of Sciences.

Human-Mouse Chimeras with Normal Expression and Function Reveal That Major Domain Swapping Is Tolerated by P-Glycoprotein (ABCB1).

M. Gottesman, M. Hall, S. Ambudkar, 2016, Biochemistry.

The FLT3 and PDGFR inhibitor crenolanib is a substrate of the multidrug resistance protein ABCB1 but does not inhibit transport function at pharmacologically relevant concentrations

S. Ambudkar, S. Shukla, M. Baer, 2015, Investigational New Drugs.

The FLT3 Inhibitor Quizartinib Inhibits ABCG2 at Pharmacologically Relevant Concentrations, with Implications for Both Chemosensitization and Adverse Drug Interactions

S. Ambudkar, S. Shukla, M. Baer, 2013, PloS one.

Preclinical Development The Novel BCR-ABL and FLT 3 Inhibitor Ponatinib Is a Potent Inhibitor of the MDR-Associated ATP-Binding Cassette Transporter ABCG 2

Hong-Bin Fang, S. Ambudkar, Zhe-Sheng Chen, 2012 .

The Novel BCR-ABL and FLT3 Inhibitor Ponatinib Is a Potent Inhibitor of the MDR-Associated ATP-Binding Cassette Transporter ABCG2

Hong-Bin Fang, S. Ambudkar, Zhe-Sheng Chen, 2012, Molecular Cancer Therapeutics.

Becatecarin (rebeccamycin analog, NSC 655649) is a transport substrate and induces expression of the ATP-binding cassette transporter, ABCG2, in lung carcinoma cells

Robert W. Robey, Suneet Shukla, S. Bates, 2009, Cancer Chemotherapy and Pharmacology.

Imatinib mesylate and nilotinib (AMN107) exhibit high-affinity interaction with ABCG2 on primitive hematopoietic stem cells

Y. Wang, S. Bates, R. Robey, 2007, Leukemia.

ABC drug transporters as molecular targets for the prevention of multidrug resistance and drug-drug interactions.

A. Calcagno, S. Ambudkar, S. Shukla, 2007, Current drug delivery.

Selective reversal of BCRP‐mediated MDR by VEGFR‐2 inhibitor ZM323881

Lili Liu, S. Ambudkar, Zhe-Sheng Chen, 2017, Biochemical pharmacology.

Differential effects of the immunosuppressive agents cyclosporin A, tacrolimus and sirolimus on drug transport by multidrug resistance proteins

S. Ambudkar, S. Shukla, H. Minderman, 2007, Cancer Chemotherapy and Pharmacology.

Elucidation of the structural basis of interaction of the BCR-ABL kinase inhibitor, nilotinib (Tasigna®) with the human ABC drug transporter P-glycoprotein

Damien Y. Duveau, M. Boxer, S. Ambudkar, 2014, Leukemia.

Differential Expression of OATP1B3 Mediates Unconjugated Testosterone Influx

D. Venzon, Ji Luo, W. Figg, 2017, Molecular Cancer Research.

ATP-binding cassette subfamily B member 1 (ABCB1) and subfamily C member 10 (ABCC10) are not primary resistance factors for cabazitaxel

S. Ambudkar, Zhe-Sheng Chen, S. Shukla, 2015, Chinese journal of cancer.

The BTK Inhibitor Ibrutinib (PCI-32765) Overcomes Paclitaxel Resistance in ABCB1- and ABCC10-Overexpressing Cells and Tumors

Bhargav A. Patel, S. Ambudkar, Zhe-Sheng Chen, 2017, Molecular Cancer Therapeutics.

Interindividual Variability in Hepatic Organic Anion-Transporting Polypeptides and P-Glycoprotein (ABCB1) Protein Expression: Quantification by Liquid Chromatography Tandem Mass Spectroscopy and Influence of Genotype, Age, and Sex

R. Evers, S. Ambudkar, S. Shukla, 2014, Drug Metabolism and Disposition.

Icotinib antagonizes ABCG2-mediated multidrug resistance, but not the pemetrexed resistance mediated by thymidylate synthase and ABCG2

S. Bates, R. Robey, S. Ambudkar, 2014, Oncotarget.

Inhibiting the function of ABCB1 and ABCG2 by the EGFR tyrosine kinase inhibitor AG1478.

S. Bates, R. Robey, S. Ambudkar, 2009, Biochemical pharmacology.

Inhibition of ABCG2-mediated transport by protein kinase inhibitors with a bisindolylmaleimide or indolocarbazole structure

S. Bates, R. Robey, S. Ambudkar, 2007, Molecular Cancer Therapeutics.

Use of Baculovirus BacMam Vectors for Expression of ABC Drug Transporters in Mammalian Cells

S. Ambudkar, S. Shukla, K. Kapoor, 2012, Drug Metabolism and Disposition.

Microsoft Word-12042809-file00

R. Robey, S. Ambudkar, S. Shukla, 2010 .

Evidence for the interaction of imatinib at the transport-substrate site(s) of the multidrug-resistance-linked ABC drug transporters ABCB1 (P-glycoprotein) and ABCG2

Z. Sauna, S. Ambudkar, S. Shukla, 2008, Leukemia.

A-803467, a tetrodotoxin-resistant sodium channel blocker, modulates ABCG2-mediated MDR in vitro and in vivo

S. Ambudkar, Zhe-Sheng Chen, S. Shukla, 2015, Oncotarget.

Curcumin Modulates Efflux Mediated by Yeast ABC Multidrug Transporters and Is Synergistic with Antifungals

S. Ambudkar, S. Shukla, R. Prasad, 2009, Antimicrobial Agents and Chemotherapy.

Modulation of function of three ABC drug transporters, P-glycoprotein (ABCB1), mitoxantrone resistance protein (ABCG2) and multidrug resistance protein 1 (ABCC1) by tetrahydrocurcumin, a major metabolite of curcumin

S. Ambudkar, S. Shukla, P. Limtrakul, 2007, Molecular and Cellular Biochemistry.

Crystal structure of the antigen-binding fragment of a monoclonal antibody specific for the multidrug-resistance-linked ABC transporter human P-glycoprotein.

L. Esser, S. Ambudkar, S. Shukla, 2016, Acta crystallographica. Section F, Structural biology communications.

Hydrogel-assisted functional reconstitution of human P-glycoprotein (ABCB1) in giant liposomes.

D. Sept, S. Ambudkar, S. Shukla, 2015, Biochimica et biophysica acta.

The skin cancer chemotherapeutic agent ingenol-3-angelate (PEP005) is a substrate for the epidermal multidrug transporter (ABCB1) and targets tumor vasculature.

Andrew Lee, S. Ambudkar, Luowei Li, 2010, Cancer research.

Linsitinib (OSI-906) antagonizes ATP-binding cassette subfamily G member 2 and subfamily C member 10-mediated drug resistance.

S. Bates, R. Robey, S. Ambudkar, 2014, The international journal of biochemistry & cell biology.

Purification and characterization of the N-terminal nucleotide binding domain of an ABC drug transporter of Candida albicans: uncommon cysteine 193 of Walker A is critical for ATP hydrolysis.

N. Karnani, S. Shukla, R. Prasad, 2003, Biochemistry.

Development of inhibitors of ATP-binding cassette drug transporters – present status and challenges

S. Ambudkar, S. Shukla, Chung-Pu Wu, 2008, Expert opinion on drug metabolism & toxicology.

Erlotinib (Tarceva, OSI-774) antagonizes ATP-binding cassette subfamily B member 1 and ATP-binding cassette subfamily G member 2-mediated drug resistance.

S. Bates, R. Robey, S. Ambudkar, 2007, Cancer research.

Functional Characterization of Candida albicans ABC Transporter Cdr1p

Smriti, S. Ambudkar, S. Shukla, 2003, Eukaryotic Cell.

The naphthoquinones, vitamin K3 and its structural analogue plumbagin, are substrates of the multidrug resistance–linked ATP binding cassette drug transporter ABCG2

Suneet Shukla, S. Ambudkar, S. Shukla, 2007, Molecular Cancer Therapeutics.

ABC Transporter-Mediated Multidrug-Resistant Cancer.

S. Ambudkar, S. Shukla, A. Tiwari, 2019, Advances in experimental medicine and biology.

Inhibition of P-glycoprotein (ABCB1)- and multidrug resistance-associated protein 1 (ABCC1)-mediated transport by the orally administered inhibitor, CBT-1((R)).

T. Fojo, S. Bates, R. Robey, 2008, Biochemical pharmacology.

Cryo-EM Analysis of the Conformational Landscape of Human P-glycoprotein (ABCB1) During its Catalytic Cycle

G. A. Frank, A. Bartesaghi, M. Borgnia, 2016, Molecular Pharmacology.

Large-scale purification of functional human P-glycoprotein (ABCB1).

S. Ambudkar, S. Shukla, Sabrina Lusvarghi, 2019, Protein expression and purification.

Screening Compounds with a Novel High-Throughput ABCB1-Mediated Efflux Assay Identifies Drugs with Known Therapeutic Targets at Risk for Multidrug Resistance Interference

S. Ambudkar, Luowei Li, S. Yuspa, 2013, PloS one.

Tyrosine kinase inhibitors as modulators of ABC transporter-mediated drug resistance.

S. Ambudkar, Zhe-Sheng Chen, S. Shukla, 2012, Drug resistance updates : reviews and commentaries in antimicrobial and anticancer chemotherapy.

Mechanistic and Pharmacological Insights into Modulation of ABC Drug Transporters by Tyrosine Kinase Inhibitors

S. Ambudkar, S. Shukla, Atish Patel, 2016 .

Sildenafil reverses ABCB1- and ABCG2-mediated chemotherapeutic drug resistance.

S. Bates, R. Robey, S. Ambudkar, 2011, Cancer research.

Synthesis and characterization of a BODIPY conjugate of the BCR-ABL kinase inhibitor Tasigna (nilotinib): evidence for transport of Tasigna and its fluorescent derivative by ABC drug transporters.

Suneet Shukla, Michael M Gottesman, M. Gottesman, 2011, Molecular pharmaceutics.

The Inhibitor Ko143 Is Not Specific for ABCG2

M. Gottesman, J. Mulder, M. Hall, 2015, The Journal of Pharmacology and Experimental Therapeutics.

The "specific" P-glycoprotein inhibitor Tariquidar is also a substrate and an inhibitor for breast cancer resistance protein (BCRP/ABCG2).

M. Gottesman, M. Hall, C. Halldin, 2011, ACS chemical neuroscience.

Botryllamides: natural product inhibitors of ABCG2.

Suneet Shukla, Kentaro Takada, Curtis J Henrich, 2009, ACS chemical biology.

Sunitinib (Sutent, SU11248), a Small-Molecule Receptor Tyrosine Kinase Inhibitor, Blocks Function of the ATP-Binding Cassette (ABC) Transporters P-Glycoprotein (ABCB1) and ABCG2

Suneet Shukla, S. Bates, R. Robey, 2009, Drug Metabolism and Disposition.

Association of the ABCG2 C421A polymorphism with prostate cancer risk and survival

S. Steinberg, R. Robey, S. Ambudkar, 2008, BJU international.

The calcium channel blockers, 1,4-dihydropyridines, are substrates of the multidrug resistance-linked ABC drug transporter, ABCG2.

Suneet Shukla, S. Bates, R. Robey, 2006, Biochemistry.

Identification of Compounds that Correlate with ABCG2 Transporter Function in the National Cancer Institute Anticancer Drug Screen

Suneet Shukla, S. Bates, S. Holbeck, 2009, Molecular Pharmacology.

Evidence for dual mode of action of a thiosemicarbazone, NSC73306: a potent substrate of the multidrug resistance–linked ABCG2 transporter

Suneet Shukla, Michael M Gottesman, Matthew D Hall, 2007, Molecular Cancer Therapeutics.

Curcumin Inhibits the Activity of ABCG2/BCRP1, a Multidrug Resistance-Linked ABC Drug Transporter in Mice

J. Ware, S. Ambudkar, S. Shukla, 2009, Pharmaceutical Research.

The linker region of breast cancer resistance protein ABCG2 is critical for coupling of ATP-dependent drug transport

S. Bates, A. di Pietro, R. Robey, 2015, Cellular and Molecular Life Sciences.

Comparison of ATP-Binding Cassette Transporter Interactions with the Tyrosine Kinase Inhibitors Imatinib, Nilotinib, and Dasatinib

S. Bates, R. Robey, S. Ambudkar, 2010, Drug Metabolism and Disposition.

Modulation of the function of the multidrug resistance–linked ATP-binding cassette transporter ABCG2 by the cancer chemopreventive agent curcumin

Suneet Shukla, S. Ambudkar, S. Shukla, 2006, Molecular Cancer Therapeutics.

Regorafenib antagonizes BCRP-mediated multidrug resistance in colon cancer.

S. Ambudkar, Zhe-Sheng Chen, S. Shukla, 2019, Cancer letters.

New inhibitors of ABCG2 identified by high-throughput screening

Michael Dean, Suneet Shukla, Curtis J Henrich, 2007, Molecular Cancer Therapeutics.

New inhibitors of ABCG 2 identified by high-throughput screening

S. Bates, J. Mcmahon, C. J. Henrich, 2007 .

Motesanib (AMG706), a potent multikinase inhibitor, antagonizes multidrug resistance by inhibiting the efflux activity of the ABCB1.

S. Ambudkar, Zhe-Sheng Chen, S. Shukla, 2014, Biochemical pharmacology.

Regorafenib overcomes chemotherapeutic multidrug resistance mediated by ABCB1 transporter in colorectal cancer: In vitro and in vivo study.

S. Ambudkar, Zhe-Sheng Chen, S. Shukla, 2017, Cancer letters.

Structures of the Multidrug Transporter P-glycoprotein Reveal Asymmetric ATP Binding and the Mechanism of Polyspecificity*♦

M. Gottesman, J. Shiloach, L. Esser, 2016, The Journal of Biological Chemistry.

Selonsertib (GS-4997), an ASK1 inhibitor, antagonizes multidrug resistance in ABCB1- and ABCG2-overexpressing cancer cells.

S. Ambudkar, Zhe-Sheng Chen, Dexin Kong, 2019, Cancer letters.

Effects of a detergent micelle environment on P-glycoprotein (ABCB1)-ligand interactions

S. Ambudkar, S. Shukla, B. Abel, 2017, The Journal of Biological Chemistry.

Thiazole-valine peptidomimetic (TTT-28) antagonizes multidrug resistance in vitro and in vivo by selectively inhibiting the efflux activity of ABCB1

Bhargav A. Patel, S. Ambudkar, Zhe-Sheng Chen, 2017, Scientific Reports.

Identification of a Cryptic Bacterial Promoter in Mouse (mdr1a) P-Glycoprotein cDNA

M. Gottesman, D. Esposito, M. Hall, 2015, PloS one.

The Inhibitor Ko 143 Is Not Specific for ABCG 2

M. Gottesman, J. Mulder, M. Hall, 2015 .

Disulfiram, an old drug with new potential therapeutic uses for human cancers and fungal infections.

Z. Sauna, S. Ambudkar, S. Shukla, 2005, Molecular bioSystems.

Glesatinib, a c-MET/SMO Dual Inhibitor, Antagonizes P-glycoprotein Mediated Multidrug Resistance in Cancer Cells

S. Ambudkar, Zhe-Sheng Chen, Dong-Hua Yang, 2019, Front. Oncol..

Human ABCB6 localizes to both the outer mitochondrial membrane and the plasma membrane.

M. Gottesman, G. Szakács, S. Akiyama, 2007, Biochemistry.

The amino acid residues of transmembrane helix 5 of multidrug resistance protein CaCdr1p of Candida albicans are involved in substrate specificity and drug transport.

S. Ambudkar, S. Shukla, R. Prasad, 2009, Biochimica et biophysica acta.

Alanine scanning of transmembrane helix 11 of Cdr1p ABC antifungal efflux pump of Candida albicans: identification of amino acid residues critical for drug efflux.

S. Shukla, R. Prasad, S. Jha, 2005, The Journal of antimicrobial chemotherapy.

Substitution of threonine-1351 in the multidrug transporter Cdr1p of Candida albicans results in hypersusceptibility to antifungal agents and threonine-1351 is essential for synergic effects of calcineurin inhibitor FK520.

S. Ambudkar, S. Shukla, R. Prasad, 2004, The Journal of antimicrobial chemotherapy.

Divergent signature motifs of nucleotide binding domains of ABC multidrug transporter, CaCdr1p of pathogenic Candida albicans, are functionally asymmetric and noninterchangeable.

S. Ambudkar, S. Shukla, R. Prasad, 2010, Biochimica et biophysica acta.

Exome Sequencing of ABCB5 Identifies Recurrent Melanoma Mutations that Result in Increased Proliferative and Invasive Capacities

M. Gottesman, Jimmy Lin, N. Qutob, 2019, The Journal of investigative dermatology.

Disulfiram is a potent modulator of multidrug transporter Cdr1p of Candida albicans.

Suneet Shukla, Zuben E Sauna, Rajendra Prasad, 2004, Biochemical and biophysical research communications.

The Pim kinase inhibitor SGI-1776 decreases cell surface expression of P-glycoprotein (ABCB1) and breast cancer resistance protein (ABCG2) and drug transport by Pim-1-dependent and -independent mechanisms.

S. Ambudkar, Zhe-Sheng Chen, S. Shukla, 2013, Biochemical pharmacology.

Conserved Asp327 of walker B motif in the N-terminal nucleotide binding domain (NBD-1) of Cdr1p of Candida albicans has acquired a new role in ATP hydrolysis.

S. Ambudkar, S. Shukla, R. Prasad, 2006, Biochemistry.

Pharmacophore Modeling of Nilotinib as an Inhibitor of ATP-Binding Cassette Drug Transporters and BCR-ABL Kinase Using a Three-Dimensional Quantitative Structure–Activity Relationship Approach

S. Ambudkar, S. Shukla, T. Talele, 2014, Molecular pharmaceutics.

Bioluminescent imaging of drug efflux at the blood–brain barrier mediated by the transporter ABCG2

R. M. Simpson, M. Gottesman, M. Hall, 2013, Proceedings of the National Academy of Sciences.

Association of the ABCG2 C421A polymorphism with prostate cancer risk and survival

S. Steinberg, R. Robey, S. Ambudkar, 2008, BJU international.

Curcumin Modulates Efflux Mediated by Yeast ABC Multidrug Transporters and Is Synergistic with Antifungals

S. Ambudkar, S. Shukla, T. Prasad, 2009, Antimicrobial Agents and Chemotherapy.

Synergistic with Antifungals Yeast Abc Multidrug Transporters and Is Curcumin Modulates Efflux Mediated By

S. Ambudkar, S. Shukla, R. Manoharlal, 2008 .

Use of Baculovirus BacMam Vectors for Expression of ABC Drug Transporters in Mammalian Cells

S. Ambudkar, S. Shukla, K. Kapoor, 2012, Drug Metabolism and Disposition.

A-803467, a tetrodotoxin-resistant sodium channel blocker, modulates ABCG2-mediated MDR in vitro and in vivo

S. Ambudkar, Zhe-Sheng Chen, S. Shukla, 2015, Oncotarget.

Divergent signature motifs of nucleotide binding domains of ABC multidrug transporter, CaCdr1p of pathogenic Candida albicans, are functionally asymmetric and noninterchangeable.

S. Ambudkar, S. Shukla, S. Shukla, 2010, Biochimica et biophysica acta.

Sunitinib (Sutent®, SU11248), a small-molecule receptor tyrosine kinase inhibitor, blocks function of the ABC transporters, P-glycoprotein (ABCB1) and ABCG2

R. Robey, S. Ambudkar, S. Shukla, 2008 .