I. Sipes

J. Saurat, P. Calow, H. Greim, 2011, Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association.

A toxicological and dermatological assessment of macrocyclic lactone and lactide derivatives when used as fragrance ingredients.

J. Saurat, P. Calow, H. Greim, 2011, Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association.

The acute hepatotoxicity of the isomers of dichlorobenzene in Fischer-344 and Sprague-Dawley rats: isomer-specific and strain-specific differential toxicity.

I. Sipes, L. Gunawardhana, E. Stine, 1991, Toxicology and applied pharmacology.

The effects of dose, route, and repeated dosing on the disposition and kinetics of tetrabromobisphenol A in male F-344 rats.

I. Sipes, A. Sólyom, R. Kuester, 2006, Toxicological sciences : an official journal of the Society of Toxicology.

RIFM fragrance ingredient safety assessment, o-tolylethanol, CAS Registry Number 19819-98-8.

A. M. Api, G. A. Burton, T. Schultz, 2022, Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association.

RIFM fragrance ingredient safety assessment, anethole (isomer unspecified), CAS Registry Number 104-46-1.

G. A. Burton, T. Schultz, D. Liebler, 2021, Food and Chemical Toxicology.

RIFM fragrance ingredient safety assessment, propyl alcohol, CAS Registry Number 71-23-8.

A. M. Api, G. A. Burton, T. Schultz, 2019, Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association.

RIFM fragrance ingredient safety assessment, butyl alcohol, CAS Registry Number 71-36-3.

A. M. Api, G. A. Burton, T. Schultz, 2019, Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association.

RIFM fragrance ingredient safety assessment, methyl 2-nonynoate, CAS Registry Number 111-80-8.

G. A. Burton, T. Schultz, D. Liebler, 2019, Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association.

Evaluation of certain food additives.

G. Williams, I. Sipes, L. R. M. dos Santos, 2005, World Health Organization technical report series.

Weight-of-evidence evaluation of reproductive and developmental effects of low doses of bisphenol A.

E. Mcconnell, L. Rhomberg, J. Goodman, 2009, Critical reviews in toxicology.

Disposition and metabolism of isoeugenol in the male Fischer 344 rat.

I. Sipes, R. Smith, D. Badger, 2002, Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association.

A toxicological and dermatological assessment of aryl alkyl alcohols when used as fragrance ingredients.

J. Saurat, P. Calow, H. Greim, 2012, Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association.

RIFM fragrance ingredient safety assessment, p-α,α-trimethylbenzyl alcohol, CAS Registry Number 1197-01-9.

A. M. Api, G. A. Burton, T. Schultz, 2020, Food and Chemical Toxicology.

RIFM fragrance ingredient safety assessment, isophytol, CAS Registry Number 505-32-8.

P. Calow, T. Schultz, D. Liebler, 2015, Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association.

A safety assessment of non-cyclic alcohols with unsaturated branched chain when used as fragrance ingredients: the RIFM expert panel.

J. Saurat, P. Calow, A. E. Rogers, 2010, Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association.

A toxicologic and dermatologic assessment of related esters and alcohols of cinnamic acid and cinnamyl alcohol when used as fragrance ingredients.

J. Saurat, P. Calow, A. E. Rogers, 2007, Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association.

Interaction of capsaicinoids with drug-metabolizing systems. Relationship to toxicity.

K Brendel, T F Burks, T. Burks, 1983, Biochemical pharmacology.

Regulation of substance P by nerve growth factor: disruption by capsaicin

T. Burks, I. Sipes, H. Yamamura, 1982, Brain Research.

Dermal absorption of phthalate diesters in rats.

D. E. Carter, I. Sipes, I G Sipes, 1989, Fundamental and applied toxicology : official journal of the Society of Toxicology.

4,4'-Dichlorobiphenyl: distribution, metabolism, and excretion in the dog and the monkey.

D. E. Carter, I. Sipes, D. Perry, 1980, Toxicology and applied pharmacology.

Toxicity of chlorobenzenes in cultured rat liver slices

A. J. Gandolfi, I. Sipes, R. Fisher, 1990 .

Inhibition of PIK 3 Signaling Pathway Members by the Ovotoxicant 4-Vinylcyclohexene Diepoxide in Rats 1

P. Hoyer, A. Keating, Nivedita Sen, 2019 .

Inhibition of PIK3 Signaling Pathway Members by the Ovotoxicant 4-Vinylcyclohexene Diepoxide in Rats1

P. Hoyer, A. Keating, Nivedita Sen, 2011, Biology of reproduction.

Inhibition of Ovarian KIT Phosphorylation by the Ovotoxicant 4-Vinylcyclohexene Diepoxide in Rats1

P. Hoyer, Nivedita Sen, I. Sipes, 2011, Biology of reproduction.

Dual protective role for glutathione S-transferase class pi against VCD-induced ovotoxicity in the rat ovary.

P. Hoyer, A. Keating, Nivedita Sen, 2010, Toxicology and applied pharmacology.

Expression of ovarian microsomal epoxide hydrolase and glutathione S-transferase during onset of VCD-induced ovotoxicity in B6C3F(1) mice.

P. Hoyer, A. Keating, I. Sipes, 2008, Toxicology and applied pharmacology.

Characterization of a rat in vitro ovarian culture system to study the ovarian toxicant 4-vinylcyclohexene diepoxide.

P. Hoyer, M. Skinner, I. Sipes, 2002, Toxicology and applied pharmacology.

Expression and Redistribution of Cellular Bad, Bax, and Bcl-xL Protein Is Associated with VCD-Induced Ovotoxicity in Rats1

P. Hoyer, I. Sipes, P. Christian, 2001, Biology of reproduction.

Effect of 4-vinylcyclohexene diepoxide dosing in rats on GSH levels in liver and ovaries.

P. Hoyer, I. Sipes, P. Devine, 2001, Toxicological sciences : an official journal of the Society of Toxicology.

Follicular mechanisms associated with 4-vinylcyclohexene diepoxide-induced ovotoxicity in rats.

J. Flaws, P. Hoyer, I. Sipes, 1996, Reproductive toxicology.

Syntheses and spectroscopic characterizations of oxidative metabolites of 4‐vinylcyclohexene

I. Sipes, E. Mash, T. Gregg, 1994 .

Hepatic bioactivation of 4-vinylcyclohexene to ovotoxic epoxides.

D. Mattison, I. Sipes, B. J. Smith, 1991, Advances in experimental medicine and biology.

Comparison of the disposition and in vitro metabolism of 4-vinylcyclohexene in the female mouse and rat.

D. E. Carter, I. Sipes, B. J. Smith, 1990, Toxicology and applied pharmacology.

Absorption, distribution, metabolism and excretion of intravenously and orally administered tetrabromobisphenol A [2,3-dibromopropyl ether] in male Fischer-344 rats.

I. Sipes, G. Knudsen, R. Kuester, 2007, Toxicology.

A reduction in mixed function oxidases and in tumor promoting effects of ethanol in a NDEA-initiated hepatocarcinogenesis model.

I. Sipes, S. Mufti, 1991, Advances in experimental medicine and biology.

RIFM fragrance ingredient safety assessment, phenylacetic acid, CAS Registry Number 103-82-2.

A. M. Api, G. A. Burton, T. Schultz, 2022, Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association.

Extra-hepatic GSH-dependent metabolism of 1,2-dibromoethane (DBE) and 1,2-dibromo-3-chloropropane (DBCP) in the rat and mouse.

A. J. Gandolfi, I. Sipes, R. Macfarland, 1984, Drug and chemical toxicology.

Upholding science in health, safety and environmental risk assessments and regulations.

G. B. Gori, H. Yamazaki, M. Aschner, 2016, Toxicology.

RIFM fragrance ingredient safety assessment, 3-phenylpropyl acetate, CAS Registry Number 122-72-5.

A. M. Api, G. A. Burton, T. Schultz, 2022, Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association.

Update to RIFM fragrance ingredient safety assessment, benzyl acetate, CAS Registry Number 140-11-4.

A. M. Api, G. A. Burton, T. Schultz, 2022, Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association.

Absorption and disposition of cobalt naphthenate in rats after a single oral dose.

D. E. Carter, I. Sipes, J. M. Firriolo, 1999, Journal of toxicology and environmental health. Part A.

Altered retrograde axonal transport of nerve growth factor after single and repeated doses of acrylamide in the rat.

M. Miller, T. Burks, M. Miller, 1983, Toxicology and applied pharmacology.

Enhanced expression of bax in small preantral follicles during 4-vinylcyclohexene diepoxide-induced ovotoxicity in the rat.

J. Tilly, P. Hoyer, I. Sipes, 1996, Toxicology and applied pharmacology.

Simultaneous determination of cyclohexene oxide and its metabolites in rat plasma and urine by gas chromatography.

I. Sipes, J. Sauer, J. Bao, 1997, Journal of chromatography. B, Biomedical sciences and applications.

Absorption, disposition kinetics, and metabolic pathways of cyclohexene oxide in the male Fischer 344 rat and female B6C3F1 mouse.

M. Cunningham, I. Sipes, J. Sauer, 1997, Drug metabolism and disposition: the biological fate of chemicals.

INDUCTION OF CYTOCHROME P-450 ENZYMES AFTER REPEATED EXPOSURE TO 4-VINYLCYCLOHEXENE IN B 6 C 3 F 1 MICE

J. Halpert, I. Sipes, J. Kraner, 1999 .

Induction of cytochrome P-450 enzymes after repeated exposure to 4-vinylcyclohexene in B6C3F1 mice.

J. Liu, J. Halpert, I. Sipes, 1999, Drug metabolism and disposition: the biological fate of chemicals.

Ovarian toxicity and metabolism of 4-vinylcyclohexene and analogues in B6C3F1 mice: structure-activity study of 4-vinylcyclohexene and analogues.

J. Doerr, I. Sipes, J. K. Doerr, 1996, Advances in experimental medicine and biology.

In vitro metabolism and bioactivation of 1,2,3-trichloropropane.

G. L. Weber, I. Sipes, 1992, Toxicology and applied pharmacology.

A dynamic liver culture system: a tool for studying chemical biotransformation and toxicity.

A. J. Gandolfi, I. Sipes, R. Fisher, 1987, Archives of toxicology. Supplement. = Archiv fur Toxikologie. Supplement.

Oxygen Concentrations Required for Reductive Defluorination of Halothane by Rat Hepatic Microsomes

A. J. Gandolfi, R. Lind, I. Sipes, 1986, Anesthesia and analgesia.

A. Vickers, I. Sipes, K. Brendel, 1986, Biochemical pharmacology.

Hepatic mixed function oxygenase activity and glutathione S-transferase activity in mice following ethanol consumption and withdrawal.

R. Schnellmann, I. Sipes, T. Smith, 1984, Toxicology.

Covalent binding of 14C-1,1,2-trichloroethane to hepatic proteins following acetone pretreatment.

A. J. Gandolfi, I. Sipes, J. Macdonald, 1982, Drug and chemical toxicology.

The in vitro metabolism and bioactivation of 1,2-dibromoethane (ethylene dibromide) by human liver.

R. Schnellmann, I. Sipes, D. Wiersma, 1986, Journal of biochemical toxicology.

Deuterium isotope effect on the metabolism and toxicity of 1,2-dibromoethane.

A. J. Gandolfi, G. T. Bowden, I. Sipes, 1983, Toxicology and applied pharmacology.

Inhibition of NADPH oxidation and related drug oxidation in liver microsomes by zinc.

J. C. Ludwig, I. Sipes, M. Chvapil, 1976, Biochemical pharmacology.

Characterization of the hepatic DNA damage caused by 1,2-dibromoethane using the alkaline elution technique.

A. J. Gandolfi, G. T. Bowden, I. Sipes, 1981, Carcinogenesis.

Vitamin A potentiation of carbon tetrachloride hepatotoxicity: enhanced lipid peroxidation without enhanced biotransformation.

I. Sipes, A. Elsisi, D. Earnest, 1993, Toxicology and applied pharmacology.

Characterization of vitamin A potentiation of carbon tetrachloride-induced liver injury.

I. Sipes, A. Elsisi, D. Earnest, 1993, Toxicology and applied pharmacology.

Hypothalamic site of action of 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD).

G. Shah, A. Buckley, I. Sipes, 1988, Toxicology and applied pharmacology.

Biotransformation of PCBs: Metabolic Pathways and Mechanisms

R. Schnellmann, I. Sipes, 1987 .

Diethyldithiocarbamate enhances production of nitric oxide and TNF-alpha by lipopolysaccharide-stimulated rat Kupffer cells.

I. Sipes, N. Hoglen, H. Ishiyama, 2000, Toxicological sciences : an official journal of the Society of Toxicology.

Vitamin A modulation of xenobiotic-induced hepatotoxicity in rodents.

I. Sipes, S. Hooser, R. Rosengren, 1994, Environmental health perspectives.

Oral and topical absorption, disposition kinetics, and the metabolic fate of trans-methyl styryl ketone in the male Fischer 344 rat.

I. Sipes, J. Sauer, R. Kuester, 1997, Drug metabolism and disposition: the biological fate of chemicals.

The role of glutathione in the toxicity of xenobiotic compounds: metabolic activation of 1,2-dibromoethane by glutathione.

I. Sipes, D. J. Armstrong, D. Wiersma, 1986, Advances in experimental medicine and biology.

Chromatographic resolution of amino acid adducts of aliphatic halides.

A. J. Gandolfi, I. Sipes, K. Brendel, 1982, Chemico-biological interactions.

The bioactivation of 1,2-dibromoethane in rat hepatocytes: deuterium isotope effect.

I. Sipes, R. D. White, T. Petry, 1984, Chemico-biological interactions.

Acetone potentiation of 1,1,2-trichloroethane hepatotoxicity.

A. J. Gandolfi, I. Sipes, J. Macdonald, 1982, Toxicology letters.

Chloroform toxicity in mice: correlation of renal and hepatic necrosis with covalent binding of metabolites to tissue macromolecules.

I. Sipes, G. Krishna, K. Ilett, 1973, Experimental and molecular pathology.

Bioactivation and covalent binding of halothane to liver macromolecules.

I. Sipes, B. R. Brown, T. Podolsky, 1977, Environmental health perspectives.

Metabolic and dispositional fate of 1,2-dibromo-2,4-dicyanobutane in the male fischer 344 Rat.

I. Sipes, J. Sauer, R. Kuester, 1998, Drug metabolism and disposition: the biological fate of chemicals.

The bioactivation of 1,2-dibromoethane in rat hepatocytes: covalent binding to nucleic acids.

I. Sipes, K. Brendel, R. D. White, 1982, Carcinogenesis.

Enhanced hepatotoxicity of carbon tetrachloride, thioacetamide, and dimethylnitrosamine by pretreatment of rats with ethanol and some comparisons with potentiation by isopropanol.

I. Sipes, H. Maling, B. Stripp, 1975, Toxicology and applied pharmacology.

RIFM fragrance ingredient safety assessment, benzoic acid, CAS Registry Number 65-85-0.

A. M. Api, G. A. Burton, T. Schultz, 2022, Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association.

Effects of Ultraviolet Light Irradiation, Carbon Tetrachloride, and Trichloroethylene on Ethane Exhalation in Rats

I. Sipes, J. Szebeni, M. Chvapil, 1987 .

RIFM fragrance ingredient safety assessment, styrene, CAS Registry Number 100-42-5.

A. M. Api, G. A. Burton, T. Schultz, 2022, Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association.

Effects of two hexachlorobiphenyl isomers on ornithine decarboxylase induction: inhibitory effects correlate with aryl hydrocarbon hydroxylase activity.

I. Sipes, C. L. Potter, D. Russell, 1985, Life sciences.

Inhibition of ornithine decarboxylase activity by 2,3,7,8-tetrachlorodibenzo-p-dioxin.

I. Sipes, C. L. Potter, D. Russell, 1982, Biochemical pharmacology.

Activation of 3':5'-cyclic AMP-dependent protein kinase and induction of ornithine decarboxylase as early events in induction of mixed-function oxygenases.

C. Byus, B. Brodie, I. Sipes, 1976, Proceedings of the National Academy of Sciences of the United States of America.

Bioactivation of carbon tetrachloride, chloroform and bromotrichloromethane: role of cytochrome P-450.

I. Sipes, G. Krishna, J. Gillette, 1977, Life sciences.

Differences between rats and mice in the involvement of the aryl hydrocarbon receptor in 4-vinylcyclohexene diepoxide-induced ovarian follicle loss.

J. Flaws, P. Hoyer, I. Sipes, 2005, Toxicology and applied pharmacology.

RIFM fragrance ingredient safety assessment, biphenyl, CAS Registry Number 92-52-4.

A. M. Api, G. A. Burton, T. Schultz, 2022, Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association.

Characterization of hepatic DNA damage induced in rats by the pyrrolizidine alkaloid monocrotaline.

G. T. Bowden, I. Sipes, R. Huxtable, 1984, Cancer research.

Comparative pharmacokinetic and disposition studies of [1-14C]1-eicosanylcyclohexane, a surrogate mineral hydrocarbon, in female Fischer-344 and Sprague-Dawley rats.

I. Sipes, C. Mackerer, J. Halladay, 2002, Drug metabolism and disposition: the biological fate of chemicals.

Comparison of random and serial sections in assessment of ovarian toxicity.

D. Mattison, I. Sipes, D. Plowchalk, 1991, Reproductive toxicology.

Update to RIFM fragrance ingredient safety assessment, 2,4-dimethylbenzyl acetate, CAS Registry Number 62346-96-7.

A. M. Api, G. A. Burton, T. Schultz, 2022, Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association.

Update to RIFM fragrance ingredient safety assessment, α-methylbenzyl acetate, CAS Registry Number 93-92-5.

A. M. Api, G. A. Burton, T. Schultz, 2022, Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association.

RIFM fragrance ingredient safety assessment, α-Methylbenzyl acetate, CAS Registry Number 93-92-5.

A. M. Api, P. Calow, T. Schultz, 2016, Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association.

Evaluation of certain food additives and contaminants.

E. Vavasour, J. Schlatter, A. Tritscher, 2007, World Health Organization technical report series.

Alteration of Kupffer cell function and morphology by low melt point paraffin wax in female Fischer-344 but not Sprague-Dawley rats.

M. Miller, I. Sipes, J. Hensel, 1998, Toxicological sciences : an official journal of the Society of Toxicology.

Preparation and composition of alveolar extracellular matrix and incorporated basement membrane

I. Sipes, R. Kuttan, K. Brendel, 2007, Lung.

Determination of parts-per-billion concentrations of indium in biological materials by electrothermal atomic absorption spectrometry following ion pair extraction.

D. E. Carter, I. Sipes, W. Zheng, 1993, Analytical chemistry.

Factors influencing halothane hepatotoxicity in the rat hypoxic model.

A. J. Gandolfi, I. Sipes, B. R. Brown, 1980, Toxicology and applied pharmacology.

Gadolinium chloride reduces cytochrome P450: relevance to chemical-induced hepatotoxicity.

I. Sipes, J. Sauer, D. Badger, 1997, Toxicology.

Liver slices in dynamic organ culture. I. An alternative in vitro technique for the study of rat hepatic drug metabolism.

I. Sipes, K. Brendel, A. Weir, 1991, Xenobiotica; the fate of foreign compounds in biological systems.

Contemporary issues in toxicology

I. Sipes, 1988 .

In vitro degradation of l-phenylalanine mustard (l-PAM)

T. L. Evans, D. Alberts, I. Sipes, 2004, Cancer Chemotherapy and Pharmacology.

Mass spectrometry of chlorambucil, its degradation products, and its metabolite in biological samples.

D. Alberts, P. Walson, I. Sipes, 1980, Journal of pharmaceutical sciences.

The stability of L-phenylalanine mustard in bile.

T. L. Evans, D. Alberts, I. Sipes, 1978, Life sciences.

Expression and activity of microsomal epoxide hydrolase in follicles isolated from mouse ovaries.

P. Hoyer, I. Sipes, P. Christian, 2002, Toxicological sciences : an official journal of the Society of Toxicology.

Modulation of 1,2-dichlorobenzene hepatotoxicity in the Fischer-344 rat by a scavenger of superoxide anions and an inhibitor of Kupffer cells.

I. Sipes, L. Gunawardhana, S. Mobley, 1993, Toxicology and applied pharmacology.

Reactive oxygen species in the progression of CCl4-induced liver injury.

I. Sipes, D. Earnest, S. Mobley, 1991, Advances in experimental medicine and biology.

Characterization of the Inhibitory Effects of N-Butylpyridinium Chloride and Structurally Related Ionic Liquids on Organic Cation Transporters 1/2 and Human Toxic Extrusion Transporters 1/2-K In Vitro and In Vivo

S. Wright, M. Hooth, I. Sipes, 2011, Drug Metabolism and Disposition.

In vitro metabolism of theophylline by rat and human liver tissue.

I. Sipes, K. Salyers, J. Barr, 1994, Xenobiotica; the fate of foreign compounds in biological systems.

Disposition and Excretion of 14C-AHTN (7-Acetyl-1,1,3,4,4,6-Hexamethyl-1,2,3,4-Tetrahydronaphthalene) and 14C-HHCB (1,3,4,6,7,8-Hexahydro-4,6,6,7,8,8-Hexamethyl-Cyclopenta-Gamma-2-Benzopyran) After Intravenous Administration to Sprague-Dawley Rats and Domestic Pigs

A. M. Api, I. Sipes, A. Api, 2013, International journal of toxicology.

17β-Estradiol Affords Protection against 4-Vinylcyclohexene Diepoxide-Induced Ovarian Follicle Loss in Fischer-344 Rats.

P. Hoyer, I. Sipes, K. Thompson, 2002, Endocrinology.

A toxicologic and dermatologic assessment of cyclopentanones and cyclopentenones when used as fragrance ingredients.

J. Saurat, P. Calow, W. Dekant, 2012, Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association.

Functional and numerical alterations induced by ethanol in the cellular immune system.

R. Watson, I. Sipes, R. Prabhala, 1988, Immunopharmacology.

RIFM fragrance ingredient safety assessment, 4-hydroxy-2,5-dimethyl-3(2H)-furanone, CAS Registry Number 3658-77-3.

A. M. Api, G. A. Burton, S. Tsang, 2020, Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association.

RIFM fragrance ingredient safety assessment, 2-(1,1-dimethylethyl)-4-methylcyclohexan-1-ol, CAS Registry Number 67634-11-1.

A. M. Api, G. A. Burton, T. Schultz, 2022, Food and Chemical Toxicology.

2,3,6,2',3',6'-hexachlorobiphenyl: distribution, metabolism, and excretion in the dog and the monkey.

D. E. Carter, I. Sipes, D. Perry, 1982, Toxicology and applied pharmacology.

2 3 6 2' 3' 6' hexa chloro bi phenyl distribution metabolism and excretion in the dog and the monkey macaca fascicularis

D. E. Carter, I. Sipes, M. L. Slocumb, 1982 .

2,4,5,2',4',5'-Hexachlorobiphenyl: distribution, metabolism, and excretion in the dog and the monkey.

D. E. Carter, I. Sipes, D. Perry, 1982, Toxicology and applied pharmacology.

involvement of microsomal epoxide hydrolase enzyme in ovotoxicity caused by 7,12-dimethylbenz[a]anthracene.

P. Hoyer, I. Sipes, K. Rajapaksa, 2006, Toxicological sciences : an official journal of the Society of Toxicology.

An Animal Model of Halothane Hepatotoxicity: Roles of Enzyme Induction and Hypoxia

I. Sipes, B. R. Brown, G. McLain, 1979, Anesthesiology.

Characterization of the Disposition and Toxicokinetics of N-Butylpyridinium Chloride in Male F-344 Rats and Female B6C3F1 Mice and Its Transport by Organic Cation Transporter 2

S. Wright, M. Hooth, I. Sipes, 2009, Drug Metabolism and Disposition.

Microsomal bioactivation and covalent binding of aliphatic halides to DNA.

A. J. Gandolfi, I. Sipes, A. Direnzo, 1982, Toxicology letters.

RIFM fragrance ingredient safety assessment, 2-dodecenal, CAS registry number 4826-62-4.

G. A. Burton, T. Schultz, D. Liebler, 2022, Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association.

RIFM fragrance ingredient safety assessment, 8-nonenal, CAS Registry number 39770-04-2.

G. A. Burton, T. Schultz, D. Liebler, 2022, Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association.

RIFM fragrance ingredient safety assessment, 3 and 4-(4-hydroxy-4-methylpentyl)-3-cyclohexene-1-carboxaldehyde, CAS registry number 31906-04-4.

A. M. Api, G. A. Burton, T. Schultz, 2022, Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association.

RIFM fragrance ingredient safety assessment, 10-undecenal, CAS Registry Number 112-45-8.

G. A. Burton, T. Schultz, D. Liebler, 2022, Food and Chemical Toxicology.

RIFM fragrance ingredient safety assessment, 2-methyloctanal, CAS Registry Number 7786-29-0.

G. A. Burton, T. Schultz, D. Liebler, 2022, Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association.

RIFM fragrance ingredient safety assessment, 9-decenal, CAS Registry Number 39770-05-3.

G. A. Burton, T. Schultz, D. Liebler, 2022, Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association.

RIFM fragrance ingredient safety assessment, nona-2-trans-6-cis-dienal, CAS registry number 557-48-2.

G. A. Burton, T. Schultz, D. Liebler, 2022, Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association.

RIFM fragrance ingredient safety assessment, trans-2-octenal, CAS registry number 2548-87-0.

G. A. Burton, T. Schultz, D. Liebler, 2022, Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association.

RIFM fragrance ingredient safety assessment, undecenal, CAS Registry Number 1337-83-3.

A. M. Api, G. A. Burton, T. Schultz, 2022, Food and Chemical Toxicology.

RIFM fragrance ingredient safety assessment, 2-ethylhexanal, CAS Registry Number 123-05-7.

A. M. Api, G. A. Burton, T. Schultz, 2022, Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association.

RIFM fragrance ingredient safety assessment, hexen-2-al, CAS Registry Number 6728-26-3.

G. A. Burton, T. Schultz, D. Liebler, 2021, Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association.

RIFM fragrance ingredient safety assessment, p-t-butyl-α-methylhydrocinnamic aldehyde, CAS Registry Number 80-54-6.

A. M. Api, G. A. Burton, S. Tsang, 2020, Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association.

RIFM fragrance ingredient safety assessment, 2,6,6-trimethylcyclohexa-1,3-dienyl methanal, CAS Registry Number 116-26-7.

G. A. Burton, T. Schultz, D. Liebler, 2020, Food and Chemical Toxicology.

Chemical respiratory allergy and occupational asthma: what are the key areas of uncertainty?

I. Sipes, D. Isola, I. Kimber, 2008, Journal of applied toxicology : JAT.

Amelioration of carbon tetrachloride-induced hepatic necrosis by post-toxicant treatment with cystamine.

A. J. Gandolfi, I. Sipes, J. Macdonald, 1986, Toxicology.

Covalent binding of halogenated volatile solvents to subcellular macromolecules in hepatocytes.

A. J. Gandolfi, M. Cunningham, I. Sipes, 1981, Life sciences.

RIFM fragrance ingredient safety assessment, linalyl cinnamate, CAS Registry Number 78-37-5.

P. Calow, T. Schultz, D. Liebler, 2016, Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association.

Human hepatic cytochrome P-450 composition as probed by in vitro microsomal metabolism of warfarin.

P. Beaune, F. Guengerich, R. Schnellmann, 1984, Drug metabolism and disposition: the biological fate of chemicals.

An all-glass apparatus for liver perfusion of lipophilic substrates. I. Construction and physical characteristics.

I. Sipes, K. Brendel, F. Meyer, 1985, Journal of pharmacological methods.

Cytotoxicity and genotoxicity of methyleugenol and related congeners-- a mechanism of activation for methyleugenol.

I. Sipes, J. Sauer, C. Mcqueen, 2000, Mutation research.

RIFM fragrance ingredient safety assessment, isobutyl alcohol, CAS Registry Number 78-83-1.

A. M. Api, G. A. Burton, T. Schultz, 2019, Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association.

RIFM fragrance ingredient safety assessment, isoamyl alcohol CAS Registry Number 123-51-3.

A. M. Api, G. A. Burton, T. Schultz, 2017, Food and Chemical Toxicology.

Structural requirements for cytoprotective agents in galactosamine-induced hepatic necrosis.

A. J. Gandolfi, I. Sipes, J. Macdonald, 1985, Toxicology and applied pharmacology.

Comparison of 2,2-bis(bromomethyl)-1,3-propanediol induced genotoxicity in UROtsa cells and primary rat hepatocytes: relevance of metabolism and oxidative stress.

I. Sipes, G. Knudsen, Pengfei Gu, 2013, Toxicology letters.

Role of reactive intermediates in halothane associated liver injury.

A. J. Gandolfi, I. Sipes, A. Gandolfi, 1981, Advances in experimental medicine and biology.

Halothane hepatotoxicity and the reduced derivative, 1,1,1-trifluoro-2-chloroethane.

I. Sipes, B. R. Brown, R. K. Baker, 1977, Environmental health perspectives.

Biotransformation and hepatotoxicity of halothane.

I. Sipes, B. R. Brown, I. Sipes, 1977, Biochemical pharmacology.

RIFM fragrance ingredient safety assessment, indole, CAS Registry Number 120-72-9.

G. A. Burton, T. Schultz, D. Liebler, 2020, Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association.

Identification and comparison of the urinary metabolites of [1,2,3-13C3]acrylic acid and [1,2,3-13C3]propionic acid in the rat by homonuclear 13C nuclear magnetic resonance spectroscopy.

G. L. Weber, S. Winter, I. Sipes, 1992, Drug metabolism and disposition: the biological fate of chemicals.

CONFLICTING MECHANISMS OF HEPATIC INJURY WITH HALOTHANE AND ENFLURANE

A. J. Gandolfi, R. Lind, I. Sipes, 1984 .

A toxicologic and dermatologic assessment of cyclic acetates when used as fragrance ingredients.

J. Saurat, P. Calow, A. E. Rogers, 2008, Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association.

Ovotoxicity in female Fischer rats and B6 mice induced by low-dose exposure to three polycyclic aromatic hydrocarbons: comparison through calculation of an ovotoxic index.

P. Hoyer, I. Sipes, P. Christian, 2000, Toxicology and applied pharmacology.

Tolerance induced by all-trans-retinol to the hepatotoxic effects of cadmium in rats: role of metallothionein expression.

A. Baines, I. Sipes, M. Waalkes, 1997, Toxicology and applied pharmacology.

RIFM fragrance ingredient safety assessment, p-isopropylbenzyl alcohol, CAS Registry Number 536-60-7.

A. M. Api, G. A. Burton, S. Tsang, 2020, Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association.

RIFM fragrance ingredient safety assessment, benzaldehyde, CAS Registry Number 100-52-7.

A. M. Api, G. A. Burton, S. Tsang, 2019, Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association.

RIFM fragrance ingredient safety assessment, p-tolyl alcohol, CAS Registry Number 589-18-4.

A. M. Api, G. A. Burton, T. Schultz, 2019, Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association.

RIFM fragrance ingredient safety assessment, Benzyl alcohol, CAS Registry Number 100-51-6.

A. M. Api, Terry W. Schultz, P. Calow, 2015, Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association.

RIFM fragrance ingredient safety assessment, amyl butyrate, CAS Registry Number 540-18-1.

G. A. Burton, T. Schultz, D. Liebler, 2020, Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association.

Update to RIFM fragrance ingredient safety assessment, eugenol, CAS Registry Number 97-53-0.

A. M. Api, G. A. Burton, T. Schultz, 2022, Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association.

Inhibition of NADPH oxidation and oxidative metabolism of drugs in liver microsomes by zinc.

J. C. Ludwig, I. Sipes, M. Chvapil, 1975, Biochemical pharmacology.

A toxicological and dermatological assessment of aryl alkyl alcohol simple acid ester derivatives when used as fragrance ingredients.

J. Saurat, P. Calow, H. Greim, 2012, Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association.

RIFM fragrance ingredient safety assessment, 4-(3,4-methylenedioxyphenyl)-2-butanone, CAS Registry Number 55418-52-5.

G. A. Burton, P. Calow, T. Schultz, 2017, Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association.

In vitro solubility and in vivo toxicity of gallium arsenide.

D. E. Carter, I. Sipes, D. Webb, 1984, Toxicology and applied pharmacology.

RIFM fragrance ingredient safety assessment, cis-jasmone, CAS registry number 488-10-8

G. A. Burton, T. Schultz, D. Liebler, 2021, Food and Chemical Toxicology.

RIFM fragrance ingredient safety assessment, cyclohexanone, CAS Registry Number 108-94-1.

A. M. Api, G. A. Burton, T. Schultz, 2020, Food and Chemical Toxicology.

RIFM fragrance ingredient safety assessment, methyl dihydrojasmonate, CAS registry number 24851-98-7.

P. Calow, T. Schultz, D. Liebler, 2015, Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association.

A toxicologic and dermatologic assessment of cinnamyl alcohol, cinnamaldehyde and cinnamic acid when used as fragrance ingredients.

J. Saurat, P. Calow, A. E. Rogers, 2005, Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association.

A toxicologic and dermatologic assessment of salicylates when used as fragrance ingredients.

H Greim, J. Saurat, P. Calow, 2007, Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association.

Safety assessment of allylalkoxybenzene derivatives used as flavouring substances - methyl eugenol and estragole.

J I Goodman, V J Feron, L. Marnett, 2002, Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association.

Criteria for the Research Institute for Fragrance Materials, Inc. (RIFM) safety evaluation process for fragrance ingredients.

A. M. Api, T W Schultz, A M Api, 2015, Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association.

RIFM fragrance ingredient safety assessment, cadinene, CAS Registry Number 29350-73-0.

G. A. Burton, T. Schultz, D. Liebler, 2022, Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association.

RIFM fragrance ingredient safety assessment, 1-cyclohexene-1-propanal, 4-(1-methylethyl)-, (4R), CAS Registry Number 1378867-81-2.

G. A. Burton, T. Schultz, D. Liebler, 2021, Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association.

RIFM fragrance ingredient safety assessment, p-mentha-1,4-diene, CAS Registry Number 99-85-4.

A. M. Api, G. A. Burton, T. Schultz, 2021, Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association.

RIFM fragrance ingredient safety assessment, ethyl 3-methyl-2-oxopentanoate, CAS Registry Number 26516-27-8.

G. A. Burton, T. Schultz, D. Liebler, 2021, Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association.

RIFM fragrance ingredient safety assessment, 6-nonenenitrile, (Z)- (9CI), CAS Registry Number 80639-54-9.

A. M. Api, G. A. Burton, T. Schultz, 2021, Food and Chemical Toxicology.

RIFM fragrance ingredient safety assessment, dihydroisocaryophyllene epoxide, CAS Registry Number 1209-61-6.

G. A. Burton, T. Schultz, D. Liebler, 2021, Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association.

Sulfhydryl-dependent biotransformation and macromolecular binding of 1,2-dibromo-2,4-dicyanobutane in blood.

I. Sipes, J. Sauer, R. Kuester, 1998, Drug metabolism and disposition: the biological fate of chemicals.

A toxicological and dermatological assessment of alkyl cyclic ketones when used as fragrance ingredients. RIFM Expert Panel.

J. Saurat, P. Calow, H. Greim, 2011, Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association.

A toxicological and dermatological assessment of alkyl cyclic ketones when used as fragrance ingredients q

J. Saurat, P. Calow, H. Greim, 2013 .

Culture medium composition affects the relative toxicities of chlorobenzenes in rat liver slices and the isolated perfused liver.

A. J. Gandolfi, I. Sipes, R. Fisher, 1993, Drug and chemical toxicology (New York, N.Y. 1978).

Role of biotransformation in the toxicity of inhalation anesthetics.

I. Sipes, R. Vaughan, B. R. Brown, 1978, Life sciences.

RIFM fragrance ingredient safety assessment, Linalool, CAS registry number 78-70-6.

P. Calow, T. Schultz, D. Liebler, 2015, Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association.

A toxicologic and dermatologic assessment of linalool and related esters when used as fragrance ingredients.

H Greim, J. Saurat, P. Calow, 2003, Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association.

Nature of the protection against carbon tetrachloride-induced hepatotoxicity produced by pretreatment with dibenamine (N-(2-chloroethyl)dibenzylamine).

I. Sipes, F. Eichelbaum, H. Maling, 1974, Biochemical pharmacology.

RIFM fragrance ingredient safety assessment, borneol, CAS registry number 507-70-0.

A. M. Api, P. Calow, T. Schultz, 2015, Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association.

RIFM fragrance ingredient safety assessment, 2-ethyl-1-hexanol, CAS registry number 104-76-7.

A. M. Api, P. Calow, T. Schultz, 2016, Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association.

RIFM fragrance ingredient safety assessment, (2E,6Z)-Nona-2,6-dien-1-ol, CAS registry number 28069-72-9.

P. Calow, T. Schultz, D. Liebler, 2015, Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association.

RIFM fragrance ingredient safety assessment, (Z)-2-penten-1-ol, CAS Registry Number 1576-95-0.

P. Calow, T. Schultz, D. Liebler, 2015, Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association.

Enhanced Hepatic Microsomal Activity by Pretreatment of Rats with Acetone or Isopropanol

I. Sipes, G. Krishna, H. Maling, 1973, Proceedings of the Society for Experimental Biology and Medicine. Society for Experimental Biology and Medicine.

In- Vitro Hepatotoxicity of Three Dichlorobenzene Isomers in Human Liver Slices

A. J. Gandolfi, C. Zukoski, C. Putnam, 1991, Human & experimental toxicology.

Cystamine modulation of galactosamine-induced hepatotoxicity.

A. J. Gandolfi, I. Sipes, J. Macdonald, 1984, Toxicology and applied pharmacology.

RIFM fragrance ingredient safety assessment, benzyl phenylacetate, CAS Registry Number 102-16-9.

G. A. Burton, T. Schultz, D. Liebler, 2022, Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association.

RIFM fragrance ingredient safety assessment, phenethyl benzoate, CAS Registry Number 94-47-3.

G. A. Burton, T. Schultz, D. Liebler, 2022, Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association.

RIFM fragrance ingredient safety assessment, phenethyl phenylacetate, CAS Registry Number 102-20-5.

G. A. Burton, T. Schultz, D. Liebler, 2021, Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association.

RIFM fragrance ingredient safety assessment, ethyl 10-undecenoate, CAS Registry Number 692-86-4.

A. M. Api, G. A. Burton, T. Schultz, 2020, Food and Chemical Toxicology.

RIFM fragrance ingredient safety assessment, 9-decenoic acid, CAS Registry Number 14436-32-9.

G. A. Burton, T. Schultz, D. Liebler, 2020, Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association.

RIFM fragrance ingredient safety assessment, 10-undecenoic acid, CAS Registry Number 112-38-9.

G. A. Burton, T. Schultz, D. Liebler, 2020, Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association.

RIFM fragrance ingredient safety assessment, 1,6-octadien-3-ol, 3,7-dimethyl-, acid-isomerized, CAS Registry Number 73018-51-6.

G. A. Burton, T. Schultz, D. Liebler, 2022, Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association.

RIFM fragrance ingredient safety assessment, linalool, CAS Registry number 78-70-6.

A. M. Api, G. A. Burton, T. Schultz, 2021, Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association.

Update to RIFM fragrance ingredient safety assessment, linalyl phenylacetate, CAS Registry Number 7143-69-3.

A. M. Api, G. A. Burton, T. Schultz, 2022, Food and Chemical Toxicology.

RIFM fragrance ingredient safety assessment, 3,7-dimethyl-1,6-nonadien-3-ol, CAS Registry Number 10339-55-6.

G. A. Burton, T. Schultz, D. Liebler, 2016, Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association.

RIFM fragrance ingredient safety assessment, linalyl benzoate, CAS Registry Number 126-64-7.

P. Calow, T. Schultz, D. Liebler, 2016, Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association.

RIFM fragrance ingredient safety assessment, l-linalool, CAS Registry Number 126-91-0.

P. Calow, T. Schultz, D. Liebler, 2016, Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association.

RIFM fragrance ingredient safety assessment, linalyl isobutyrate, CAS registry number 78-35-3.

A. M. Api, P. Calow, T. Schultz, 2015, Food and Chemical Toxicology.

RIFM fragrance ingredient safety assessment, Linalyl isovalerate, CAS Registry Number 1118-27-0.

A. M. Api, P. Calow, T. Schultz, 2015, Food and Chemical Toxicology.

RIFM fragrance ingredient safety assessment, Linalyl acetate, CAS Registry Number 115-95-7.

P. Calow, T. Schultz, D. Liebler, 2015, Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association.

RIFM fragrance ingredient safety assessment, Linalyl hexanoate, CAS Registry Number 7779-23-9.

P. Calow, T. Schultz, D. Liebler, 2015, Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association.

A toxicologic and dermatologic assessment of cyclic and non-cyclic terpene alcohols when used as fragrance ingredients.

J. Saurat, P. Calow, A. E. Rogers, 2008, Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association.

Halothane Metabolism in Acyanotic and Cyanotic Patients Undergoing Open Heart Surgery

A. J. Gandolfi, Roger A. Moore, R. Moore, 1986, Anesthesia and analgesia.

Hepatic cysteamine and non-protein sulfhydryl levels following cystamine or cysteamine treatment of galactosamine-poisoned rats.

A. J. Gandolfi, I. Sipes, J. Macdonald, 1985, Drug and chemical toxicology.

Cryopreservation of pig and human liver slices.

A. J. Gandolfi, C. Putnam, I. Sipes, 1991, Cryobiology.

Liver slices in dynamic organ culture. II. An in vitro cellular technique for the study of integrated drug metabolism using human tissue.

I. Sipes, K. Brendel, A. Weir, 1991, Xenobiotica; the fate of foreign compounds in biological systems.

RIFM fragrance ingredient safety assessment, methyl ionone (mixture of isomers), CAS registry number 1335-46-2.

A. M. Api, G. A. Burton, S. Tsang, 2019, Food and Chemical Toxicology.

RIFM fragrance ingredient safety assessment, Eugenol, CAS Registry Number 97-53-0.

P. Calow, T. Schultz, D. Liebler, 2016, Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association.

RIFM fragrance ingredient safety assessment, benzyl benzoate, CAS Registry Number 120-51-4.

G. A. Burton, T. Schultz, D. Liebler, 2020, Food and Chemical Toxicology.

Update to RIFM fragrance ingredient safety assessment, 4-(3,4-methylenedioxyphenyl)-2-butanone, CAS Registry Number 55418-52-5.

G. A. Burton, T. Schultz, D. Liebler, 2022, Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association.

RIFM fragrance ingredient safety assessment, 4-(p-hydroxyphenyl)-2-butanone, CAS Registry Number 5471-51-2.

G. A. Burton, T. Schultz, D. Liebler, 2019, Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association.

RIFM fragrance ingredient safety assessment, furfuryl thioacetate, CAS Registry Number 13678-68-7.

G. A. Burton, T. Schultz, D. Liebler, 2020, Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association.

Rat hepatic DNA damage induced by 1,2,3-trichloropropane.

G. L. Weber, I. Sipes, G. Weber, 1991, Advances in experimental medicine and biology.

Characterization of Dimethylnitrosamineinduced Focal and Nodular Lesions in the Livers of Newborn Mice

A. J. Gandolfi, I. Sipes, K. Cater, 1985, Toxicologic pathology.

Gas-chromatographic method for the halothane metabolites, trifluoroacetic acid and bromide, in biological fluids.

A. J. Gandolfi, I. Sipes, R. Maiorino, 1980, Journal of analytical toxicology.

RIFM fragrance ingredient safety assessment, 2-methoxy-4-propylphenol, CAS Registry Number 2785-87-7.

G. A. Burton, T. Schultz, D. Liebler, 2020, Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association.

Covalent interactions of 1,2,3-trichloropropane with hepatic macromolecules: studies in the male F-344 rat.

G. L. Weber, I. Sipes, 1990, Toxicology and applied pharmacology.

RIFM fragrance ingredient safety assessment, eucalyptol, CAS Registry Number 470-82-6.

G. A. Burton, T. Schultz, D. Liebler, 2021, Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association.

RIFM fragrance ingredient safety assessment, 1,4-cineole, CAS Registry Number 470-67-7.

G. A. Burton, T. Schultz, D. Liebler, 2020, Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association.

RIFM fragrance ingredient safety assessment, 2,6-octadienal, 3,6,7-trimethyl-, CAS Registry Number 1891-67-4.

A. M. Api, G. A. Burton, T. Schultz, 2021, Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association.

RIFM fragrance ingredient safety assessment, farnesal, CAS Registry Number 19317-11-4.

A. M. Api, G. A. Burton, T. Schultz, 2021, Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association.

RIFM fragrance ingredient safety assessment, citronellal, CAS Registry Number 106-23-0.

G. A. Burton, T. Schultz, D. Liebler, 2021, Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association.

RIFM fragrance ingredient safety assessment, 3,7-dimethyl-3,6-octadienal, CAS Registry Number 55722-59-3.

G. A. Burton, T. Schultz, D. Liebler, 2020, Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association.

RIFM fragrance ingredient safety assessment, citral, CAS Registry Number 5392-40-5.

A. M. Api, G. A. Burton, Terry W. Schultz, 2020, Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association.

RIFM fragrance ingredient safety assessment, 5,9-dimethyl-4,8-decadienal, CAS Registry Number 762-26-5.

G. A. Burton, T. Schultz, D. Liebler, 2020, Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association.

RIFM fragrance ingredient safety assessment, 3,7-dimethyl-2,6-nonadien-1-al, CAS Registry Number 41448-29-7.

A. M. Api, G. A. Burton, S. Tsang, 2020, Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association.

RIFM fragrance ingredient safety assessment, 4,8-dimethyl-4,9-decadienal, CAS Registry Number 71077-31-1.

G. A. Burton, T. Schultz, D. Liebler, 2019, Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association.

RIFM fragrance ingredient safety assessment, 2,6-Dimethyl-5-heptenal, CAS Registry Number 106-72-9.

P. Calow, T. Schultz, D. Liebler, 2015, Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association.

Suppression of Kupffer cell function prevents cadmium induced hepatocellular necrosis in the male Sprague-Dawley rat.

I. Sipes, M. Waalkes, J. Sauer, 1997, Toxicology.

Vitamin A potentiation of carbon tetrachloride hepatotoxicity: role of liver macrophages and active oxygen species.

I. Sipes, A. Elsisi, D. Earnest, 1993, Toxicology and applied pharmacology.

Comparison of the Requirements for Hepatic Injury with Halothane and Enflurane in Rats

A. J. Gandolfi, R. Lind, I. Sipes, 1985, Anesthesia and analgesia.

Induction of DNA damage in human urothelial cells by the brominated flame retardant 2,2-bis(bromomethyl)-1,3-propanediol: role of oxidative stress.

A. Gallegos, I. Sipes, R. Kuester, 2011, Toxicology.

In Vitro Glucuronidation of 2,2-Bis(bromomethyl)-1,3-propanediol by Microsomes and Hepatocytes from Rats and Humans

I. Sipes, R. Kuester, Simone I Hoehle, 2010, Drug Metabolism and Disposition.

Microsoft Word-97013786-file00

I. Sipes, R. Kuester, Simone I Hoehle, 2010 .

Absorption, Distribution, Metabolism, and Excretion of 2,2-Bis(bromomethyl)-1,3-propanediol in Male Fischer-344 Rats

I. Sipes, G. Knudsen, J. M. Sanders, 2009, Drug Metabolism and Disposition.

Metabolism of 2,2',3,3',6,6'-hexachlorobiphenyl and 2,2',4,4',5,5'-hexachlorobiphenyl by human hepatic microsomes.

C. Putnam, R. Schnellmann, I. Sipes, 1983, Biochemical pharmacology.

RIFM fragrance ingredient safety assessment, phenol, CAS Registry Number 108-95-2.

A. M. Api, G. A. Burton, T. Schultz, 2020, Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association.

Comparison of the pharmacokinetics of several polychlorinated biphenyls in mouse, rat, dog, and monkey by means of a physiological pharmacokinetic model.

R. Lutz, H. Matthews, I. Sipes, 1984, Drug metabolism and disposition: the biological fate of chemicals.

RIFM fragrance ingredient safety assessment, benzyl acetone, CAS Registry Number 2550-26-7.

G. A. Burton, T. Schultz, D. Liebler, 2019, Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association.

Risk assessment of chemical mixtures: biologic and toxicologic issues.

H J Clewell, M M Mumtaz, H. Clewell, 1993, Fundamental and applied toxicology : official journal of the Society of Toxicology.

Long-term ovarian and gonadotropin changes in mice exposed to 4-vinylcyclohexene.

P. Hoyer, I. Sipes, S. Hooser, 1994, Reproductive toxicology.

NTP-CERHR Expert Panel Report on the reproductive and developmental toxicity of fluoxetine.

Paige L. Williams, K. McMartin, M. Keszler, 2004, Birth defects research. Part B, Developmental and reproductive toxicology.

Effect of 4-Vinylcyclohexene Diepoxide on Xenobiotic Metabolizing Enzyme Expression in the Rat Ovary.

P. Hoyer, A. Keating, Nivedita Sen, 2008 .

CHARACTERIZATION OF HYPOXIC MODEL FOR HALOTHANE HEPATOTOXICITY

A. J. Gandolfi, I. Sipes, B. R. Brown, 1979 .

Bioactivation and covalent binding of halothane in vitro: studies with [3H]- and [14C]halothane.

A. J. Gandolfi, I. Sipes, L. Pohl, 1980, The Journal of pharmacology and experimental therapeutics.

Casarett and Doull's toxicology: The basic science of poisons Second edition. Edited by J. Doull, C. D. Klaassen, and M. O. Amdur. Macmillan, 1980

I. Sipes, 1982 .

Further evidence of cyclic AMP-mediated hypertrophy as a prerequisite of drug-specific enzyme induction.

I. Sipes, M. Costa, D. Russell, 1978, Biochemical pharmacology.

RIFM fragrance ingredient safety assessment, 2-phenoxyethanol, CAS Registry Number 122-99-6.

A. M. Api, G. A. Burton, T. Schultz, 2019, Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association.

Alterations in chemically induced tissue injury related to all-trans-retinol pretreatment in rodents.

A. Baines, I. Sipes, J. Sauer, 1995, Drug metabolism reviews.

Evidence for a Role of the Immune System in the Pathogenesis of Halothane Hepatitis

A. J. Gandolfi, H. Satoh, I. Sipes, 1986 .

RIFM fragrance ingredient safety assessment, 3-phenylpropionic acid, CAS Registry Number 501-52-0.

G. A. Burton, T. Schultz, D. Liebler, 2019, Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association.

RIFM fragrance ingredient safety assessment, allyl phenylacetate, CAS registry number 1797-74-6.

A. M. Api, T. W. Schultz, P. Calow, 2015, Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association.

Detection of covalently bound halothane metabolites in the hypoxic rat model for halothane hepatotoxicity.

A. J. Gandolfi, I. Sipes, B. R. Brown, 1981, Fundamental and applied toxicology : official journal of the Society of Toxicology.

Pulmonary Biotransformation of Methoxyflurane: An In-vitro Study in the Rabbit

I. Sipes, B. R. Brown, Casey D. Blitt, 1979, Anesthesiology.

Mechanisms of Acute Hepatic Toxicity: Chloroform, Halothane, and Glutathione

I. Sipes, B. R. Brown, A. Sagalyn, 1974, Anesthesiology.

The Involvement of Endotoxin in Halothane‐associated Liver Injury

A. J. Gandolfi, R. Lind, I. Sipes, 1984, Anesthesiology.

Factors Affecting the Formation of Chlorotrifluoroethane and Chlorodifluoroethylene from Halothane

A. J. Gandolfi, R. Lind, I. Sipes, 1981, Anesthesiology.

Comparison of the biotransformation and hepatotoxicity of halothane and deuterated halothane.

A. J. Gandolfi, I. Sipes, L. Pohl, 1980, The Journal of pharmacology and experimental therapeutics.

RIFM fragrance ingredient safety assessment, cinnamaldehyde, CAS Registry Number 104-55-2.

A. M. Api, G. A. Burton, S. Tsang, 2019, Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association.

RIFM fragrance ingredient safety assessment, 3(2H)-furanone, 5-ethyl-4-hydroxy-2-methyl-, CAS Registry Number 27538-09-6.

A. M. Api, G. A. Burton, T. Schultz, 2021, Food and Chemical Toxicology.

1,2-Dichlorobenzene-induced lipid peroxidation in male Fischer 344 rats is Kupffer cell dependent.

I. Sipes, D. Hartley, N. Hoglen, 1998, Toxicological sciences : an official journal of the Society of Toxicology.

Purification and characterization of the dog hepatic cytochrome P-450 isozyme responsible for the metabolism of 2,2',4,4',5,5'-hexachlorobiphenyl.

D. B. Duignan, J. Halpert, I. Sipes, 1986, Archives of biochemistry and biophysics.

The liver as a target for chemical-chemical interactions.

I. Sipes, J. Sauer, L. Gunawardhana, 1997, Advances in pharmacology.

Weight-of-Evidence Evaluation of Reproductive and Developmental Effects of Low Doses of Bisphenol A

Julie E. Goodman, Ernest E. McConnell, Lorenz R. Rhomberg, 2009 .

Weight of the Evidence Evaluation of Low-Dose Reproductive and Developmental Effects of Bisphenol A

Joshua T. Cohen, George M. Gray, Donald R. Mattison, 2004 .

Rapid isolation of type II pneumocytes with magnetic removal of macrophages.

I. Sipes, K. Brendel, E. Meezan, 1983, Experimental lung research.

Disposition of 1,2,3-trichloropropane in the Fischer 344 rat: conventional and physiological pharmacokinetics.

D. E. Carter, J. Gross, I. Sipes, 1984, Toxicology and applied pharmacology.

Hepatic injury and lipid peroxidation during hemorrhagic shock and resuscitation.

D. Liebler, I. Sipes, R. Dart, 1993, Life sciences.

RIFM fragrance ingredient safety assessment, α-pinene, CAS Registry Number 80-56-8.

A. M. Api, G. A. Burton, T. Schultz, 2021, Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association.

Testicular germ cell toxicity caused by vinylcyclohexene diepoxide in mice.

P. Hoyer, I. Sipes, S. Hooser, 1995, Reproductive toxicology.

The hydroxylation, dechlorination, and glucuronidation of 4,4'-dichlorobiphenyl (4-DCB) by human hepatic microsomes.

C. Putnam, R. Schnellmann, I. Sipes, 1984, Biochemical pharmacology.

Metabolism and disposition of [(14)C]1-nitronaphthalene in male Sprague-Dawley rats.

I. Sipes, J. Sauer, J. Halladay, 1999, Drug metabolism and disposition: the biological fate of chemicals.

Expression and activity of cytochromes P450 2E1, 2A, and 2B in the mouse ovary: the effect of 4-vinylcyclohexene and its diepoxide metabolite.

P. Hoyer, I. Sipes, P. Christian, 2003, Toxicological sciences : an official journal of the Society of Toxicology.

RIFM fragrance ingredient safety assessment, decanoic acid, CAS Registry Number 334-48-5.

A. M. Api, G. A. Burton, T. Schultz, 2020, Food and Chemical Toxicology.

RIFM fragrance ingredient safety assessment, octanoic acid, CAS Registry Number 124-07-2.

G. A. Burton, T. Schultz, D. Liebler, 2020, Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association.

Toxicokinetics of sulfasalazine (salicylazosulfapyridine) and its metabolites in B6C3F1 mice.

S. Winter, I. Sipes, M. Mayersohn, 1993, Drug metabolism and disposition: the biological fate of chemicals.

Effect of CYP2E1 gene deletion in mice on expression of microsomal epoxide hydrolase in response to VCD exposure.

I Glenn Sipes, P. Hoyer, A. Keating, 2008, Toxicological sciences : an official journal of the Society of Toxicology.

Involvement of CYP 2E1 enzyme in ovotoxicity caused by 4-vinylcyclohexene and its metabolites.

P. Hoyer, I. Sipes, E. Cannady, 2007, Toxicology and applied pharmacology.

Development of an animal model for ovotoxicity using 4-vinylcyclohexene: a case study.

P. Hoyer, I. Sipes, I. Sipes, 2007, Birth defects research. Part B, Developmental and reproductive toxicology.

Role of induction of specific hepatic cytochrome P450 isoforms in epoxidation of 4-vinylcyclohexene.

J. Halpert, P. Hoyer, I. Sipes, 2001, Drug metabolism and disposition: the biological fate of chemicals.

Evaluation of hepatic cytochrome P4502E1 in the species-dependent bioactivation of 4-vinylcyclohexene.

P. Hoyer, I. Sipes, S. Fontaine, 2001, Life sciences.

Ovarian toxicity of 4-vinylcyclohexene and related olefins in B6C3F1 mice: role of diepoxides.

J. Doerr, I. Sipes, S. Hooser, 1995, Chemical research in toxicology.

Reduced ability of rat preantral ovarian follicles to metabolize 4-vinyl-1-cyclohexene diepoxide in vitro.

J. Flaws, P. Hoyer, I. Sipes, 1994, Toxicology and applied pharmacology.

The biochemical basis for the species difference in hepatic microsomal 4-vinylcyclohexene epoxidation between female mice and rats.

J. Halpert, I. Sipes, J. Stevens, 1990, Carcinogenesis.

The role of epoxidation in 4-vinylcyclohexene-induced ovarian toxicity.

D. Mattison, I. Sipes, B. J. Smith, 1990, Toxicology and applied pharmacology.

Metabolism of bisphenol a in primary cultured hepatocytes from mice, rats, and humans.

I. Sipes, I G Sipes, J J Pritchett, 2002, Drug metabolism and disposition: the biological fate of chemicals.

Genotoxicity of the pyrrolizidine alkaloid jacobine in rats.

D. Buhler, G. T. Bowden, I. Sipes, 1986, Toxicology letters.

RIFM fragrance ingredient safety assessment, allyl (cyclohexyloxy)acetate, CAS registry number 68901-15-5.

A. M. Api, P. Calow, T. Schultz, 2015, Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association.

RIFM fragrance ingredient safety assessment, butyl acetate, CAS Registry Number 123-86-4.

A. M. Api, G. A. Burton, T. Schultz, 2022, Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association.

RIFM fragrance ingredient safety assessment, ethyl butyrate, CAS registry number 105-54-4.

G. A. Burton, T. Schultz, D. Liebler, 2022, Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association.

RIFM fragrance ingredient safety assessment, butyl butyrate, CAS Registry Number 109-21-7.

A. M. Api, G. A. Burton, T. Schultz, 2020, Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association.

RIFM fragrance ingredient safety assessment, pentyl acetate, CAS Registry Number 628-63-7.

A. M. Api, G. A. Burton, T. Schultz, 2020, Food and Chemical Toxicology.

RIFM fragrance ingredient safety assessment, amyl valerate, CAS Registry Number 2173-56-0.

G. A. Burton, T. Schultz, D. Liebler, 2020, Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association.

RIFM fragrance ingredient safety assessment, hexyl isobutyrate, CAS Registry Number 2349-07-7.

G. A. Burton, T. Schultz, D. Liebler, 2019, Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association.

RIFM fragrance ingredient safety assessment, isobutyl propionate, CAS Registry Number 540-42-1.

G. A. Burton, T. Schultz, D. Liebler, 2019, Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association.

RIFM fragrance ingredient safety assessment, hexyl butyrate, CAS Registry Number 2639-63-6.

G. A. Burton, T. Schultz, D. Liebler, 2019, Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association.

RIFM fragrance ingredient safety assessment, isobutyl acetate, CAS Registry Number 110-19-0.

G. A. Burton, T. Schultz, D. Liebler, 2019, Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association.

RIFM fragrance ingredient safety assessment, 2-methylbutyl acetate, CAS Registry Number 624-41-9.

A. M. Api, G. A. Burton, T. Schultz, 2018, Food and Chemical Toxicology.

RIFM fragrance ingredient safety assessment, isobutyl butyrate, CAS Registry Number 539-90-2.

G. A. Burton, T. Schultz, D. Liebler, 2018, Food and Chemical Toxicology.

RIFM fragrance ingredient safety assessment, hexyl formate, CAS Registry Number 629-33-4.

G. A. Burton, T. Schultz, D. Liebler, 2018, Food and Chemical Toxicology.

RIFM fragrance ingredient safety assessment, Octyl acetate, CAS Registry Number 112-14-1.

G. A. Burton, T. Schultz, D. Liebler, 2018, Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association.

RIFM fragrance ingredient safety assessment, 2-methylbutyl butyrate, CAS Registry Number 51115-64-1.

G. A. Burton, T. Schultz, D. Liebler, 2018, Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association.

RIFM fragrance ingredient safety assessment, butyl benzoate, CAS registry number 136-60-7.

G. A. Burton, T. Schultz, D. Liebler, 2018, Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association.

RIFM fragrance ingredient safety assessment, hexyl propionate, CAS registry number 2445-76-3.

G. A. Burton, T. Schultz, D. Liebler, 2018, Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association.

RIFM fragrance ingredient safety assessment, octyl formate, CAS Registry Number 112-32-3.

G. A. Burton, T. Schultz, D. Liebler, 2018, Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association.

RIFM fragrance ingredient safety assessment, Hexyl acetate, CAS Registry Number 142-92-7.

A. M. Api, G. A. Burton, T. Schultz, 2018, Food and Chemical Toxicology.

RIFM fragrance ingredient safety assessment, phenylethyl anthranilate, CAS Registry Number 133-18-6.

G. A. Burton, T. Schultz, D. Liebler, 2020, Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association.

RIFM fragrance ingredient safety assessment, methyl N-methylanthranilate, CAS Registry Number 85-91-6

A. M. Api, G. A. Burton, T. Schultz, 2021, Food and Chemical Toxicology.

Modulation of Kupffer cell and peripheral blood monocyte activity by in vivo treatment of rats with all-trans-retinol.

R. McCuskey, I. Sipes, J. Sauer, 2008, Liver.

Central nervous system effects of fenfluramine hydrochloride.

I. Sipes, J. Buckley, W. Kinnard, 1972, Journal of Pharmacology and Experimental Therapeutics.

Pharmacokinetics of acrylamide in Fisher-344 rats.

D. E. Carter, M. Miller, I. Sipes, 1982, Toxicology and applied pharmacology.

Role of cytochrome P4502E1 in retinol's attenuation of carbon tetrachloride-induced hepatotoxicity in the Swiss Webster mouse.

I. Sipes, R. Rosengren, B. J. Bray, 1999, Toxicological sciences : an official journal of the Society of Toxicology.

Distribution, excretion, and metabolism of butylbenzyl phthalate in the rat.

D. E. Carter, I. Sipes, H. Bozigian, 1986, Journal of toxicology and environmental health.

Stimulation of microsomal dimethylnitrosamine-N-demethylase by pretreatment of mice with acetone.

I. Sipes, M. L. Slocumb, G. Holtzman, 1978, Chemico-biological interactions.

Activation of Mitogen-Activated Protein Kinases and AP-1 Transcription Factor in Ovotoxicity Induced by 4-Vinylcyclohexene Diepoxide in Rats1

J. Flaws, P. Hoyer, I. Sipes, 2002, Biology of reproduction.

Vitamin A potentiation of vinylidene chloride hepatotoxicity in rats and precision-cut rat liver slices.

A. J. Gandolfi, I. Sipes, D. Badger, 1996, Fundamental and applied toxicology : official journal of the Society of Toxicology.

The interactions between retinol and five different hepatotoxicants in the Swiss Webster mouse.

I. Sipes, J. Sauer, S. Hooser, 1995, Fundamental and applied toxicology : official journal of the Society of Toxicology.

All-trans-retinol alteration of 1-nitronaphthalene-induced pulmonary and hepatic injury by modulation of associated inflammatory responses in the male Sprague-Dawley rat.

I. Sipes, J. Sauer, S. Hooser, 1995, Toxicology and applied pharmacology.

Modulation of chemical-induced lung and liver toxicity by all-trans-retinol in the male Sprague-Dawley rat.

I. Sipes, J. Sauer, 1995, Toxicology.

RIFM fragrance ingredient safety assessment, cyclohexanol, CAS Registry Number 108-93-0.

G. A. Burton, T. Schultz, D. Liebler, 2021, Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association.

RIFM fragrance ingredient safety assessment, cyclohexyl acetate, CAS Registry Number 622-45-7.

G. A. Burton, T. Schultz, D. Liebler, 2019, Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association.

RIFM fragrance ingredient safety assessment, cyclohexyl butyrate, CAS Registry Number 1551-44-6.

G. A. Burton, T. Schultz, D. Liebler, 2019, Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association.

Differential hepatotoxicity induced by cadmium in Fischer 344 and Sprague-Dawley rats.

R. McCuskey, B. Fisher, I. Sipes, 2002, Toxicological sciences : an official journal of the Society of Toxicology.

Effect of chronic dietary ethanol consumption on the initiation and promotion of chemically-induced esophageal carcinogenesis in experimental rats.

I. Sipes, S. Mufti, S. Mufti, 1989, Carcinogenesis.

Inhibition of ethanol induced ethane exhalation by carcinogenic pretreatment of rats 12 months earlier.

R. Watson, I. Sipes, J. Szebeni, 1986, Life sciences.

Species difference in the ovarian toxicity of 1,3-butadiene epoxides in B6C3F1 mice and Sprague-Dawley rats.

J. Doerr, I. Sipes, E. A. Hollis, 1996, Toxicology.

RIFM fragrance ingredient safety assessment, isoamyl salicylate, CAS registry number 87-20-7.

P. Calow, T. Schultz, D. Liebler, 2015, Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association.

A safety assessment of branched chain saturated alcohols when used as fragrance ingredients.

J. Saurat, P. Calow, A. E. Rogers, 2010, Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association.

An Updated Weight of the Evidence Evaluation of Reproductive and Developmental Effects of Low Doses of Bisphenol A

Julie E Goodman, Lorenz R Rhomberg, I Glenn Sipes, 2006, Critical reviews in toxicology.

RIFM fragrance ingredient safety assessment, p-tert-butylacetophenone, CAS Registry Number 943-27-1.

A. M. Api, G. A. Burton, T. Schultz, 2018, Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association.

RIFM fragrance ingredient safety assessment, α-methylbenzyl alcohol, CAS registry number 98-85-1.

A. M. Api, G. A. Burton, T. Schultz, 2017, Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association.

A toxicologic and dermatologic assessment of ionones when used as fragrance ingredients.

J. Saurat, P. Calow, A. E. Rogers, 2007, Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association.

Hypothyroxinemia and hypothermia in rats in response to 2,3,7,8-tetrachlorodibenzo-p-dioxin administration.

I. Sipes, C. L. Potter, D. Russell, 1983, Toxicology and applied pharmacology.

RIFM fragrance ingredient safety assessment, 2-butanone, CAS Registry Number 78-93-3.

A. M. Api, G. A. Burton, T. Schultz, 2019, Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association.

RIFM fragrance ingredient safety assessment, p-cresol, CAS Registry Number 106-44-5.

G. A. Burton, T. Schultz, D. Liebler, 2021, Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association.

RIFM fragrance ingredient safety assessment, cresol (mixed isomers), CAS Registry Number 1319-77-3.

A. M. Api, G. A. Burton, T. Schultz, 2021, Food and Chemical Toxicology.

RIFM fragrance ingredient safety assessment, o-cresol, CAS Registry Number 95-48-7.

A. M. Api, G. A. Burton, T. Schultz, 2021, Food and Chemical Toxicology.

RIFM fragrance ingredient safety assessment, m-cresol, CAS Registry Number 108-39-4.

G. A. Burton, T. Schultz, D. Liebler, 2021, Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association.

RIFM fragrance ingredient safety assessment, 2-nonanone, CAS Registry Number 821-55-6.

A. M. Api, G. A. Burton, T. Schultz, 2020, Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association.

RIFM fragrance ingredient safety assessment, 2-decanone, CAS Registry Number 693-54-9.

A. M. Api, G. A. Burton, T. Schultz, 2020, Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association.

RIFM fragrance ingredient safety assessment, 2-undecanone, CAS Registry Number 112-12-9.

A. M. Api, G. A. Burton, T. Schultz, 2019, Food and Chemical Toxicology.

RIFM fragrance ingredient safety assessment, 2-heptanone, CAS Registry Number 110-43-0.

G. A. Burton, T. Schultz, D. Liebler, 2019, Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association.

RIFM fragrance ingredient safety assessment, 3-hexanone, CAS Registry Number 589-38-8.

G. A. Burton, T. Schultz, D. Liebler, 2019, Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association.

RIFM fragrance ingredient safety assessment, 3-octanone, CAS Registry Number 106-68-3.

G. A. Burton, T. Schultz, D. Liebler, 2019, Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association.

RIFM fragrance ingredient safety assessment, 3-heptanone, CAS Registry Number 106-35-4.

G. A. Burton, T. Schultz, D. Liebler, 2019, Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association.

RIFM fragrance ingredient safety assessment, 2-octanone, CAS Registry Number 111-13-7.

G. A. Burton, T. Schultz, D. Liebler, 2019, Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association.

RIFM fragrance ingredient safety assessment, 4-heptanone, CAS Registry Number 123-19-3.

G. A. Burton, T. Schultz, D. Liebler, 2019, Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association.

RIFM fragrance ingredient safety assessment, n-hexane, CAS Registry Number 110-54-3.

G. A. Burton, T. Schultz, D. Liebler, 2022, Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association.

RIFM fragrance ingredient safety assessment, 5-methyl-3-heptanone, CAS Registry Number 541-85-5.

A. M. Api, G. A. Burton, T. Schultz, 2020, Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association.

RIFM fragrance ingredient safety assessment, 2,6,8-trimethylnonan-4-one, CAS Registry Number 123-18-2.

A. M. Api, G. A. Burton, T. Schultz, 2019, Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association.

RIFM fragrance ingredient safety assessment, 4-methyl-2-pentanone, CAS Registry Number 108-10-1.

A. M. Api, G. A. Burton, S. Tsang, 2019, Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association.

Microsoft Word-39079680-file00

S. Wright, M. Hooth, I. Sipes, 2009 .

Characterization of Hepatic DMA Damage Induced in Rats by the Pyrrolizidine Alkaloid Monocrotaline1

G. T. Bowden, I. Sipes, R. Huxtable, 2006 .

RIFM fragrance ingredient safety assessment, dimethyl sulfide, CAS Registry Number 75-18-3.

G. A. Burton, T. Schultz, D. Liebler, 2020, Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association.

RIFM fragrance ingredient safety assessment, butyl sulfide, CAS Registry Number 544-40-1.

G. A. Burton, T. Schultz, D. Liebler, 2019, Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association.

RIFM fragrance ingredient safety assessment, dl-limonene (racemic), CAS Registry Number 138-86-3.

A. M. Api, G. A. Burton, T. Schultz, 2021, Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association.

RIFM fragrance ingredient safety assessment, dodecane, CAS Registry Number 112-40-3.

G. A. Burton, T. Schultz, D. Liebler, 2020, Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association.

RIFM fragrance ingredient safety assessment, undecane, CAS Registry Number 1120-21-4.

G. A. Burton, T. Schultz, D. Liebler, 2020, Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association.

RIFM FRAGRANCE INGREDIENT SAFETY ASSESSMENT, 2,6-Dimethylocta-2,4,6-triene, CAS Registry Number 673-84-7.

G. A. Burton, T. Schultz, D. Liebler, 2018, Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association.

Evaluation of ovotoxicity induced by 7, 12-dimethylbenz[a]anthracene and its 3,4-diol metabolite utilizing a rat in vitro ovarian culture system.

P. Hoyer, A. Keating, I. Sipes, 2009, Toxicology and applied pharmacology.

Dibenamine impairment of rat hepatic microsomal enzymes and its relation to hepatotoxicity induced by CCl4 and dimethylnitrosamine.

I. Sipes, H. Maling, J. Gillette, 1974, Drug metabolism and disposition: the biological fate of chemicals.

Prediction of Metabolic Clearance of Bisphenol A (4,4 ′-Dihydroxy-2,2-diphenylpropane) using Cryopreserved Human Hepatocytes

I. Sipes, R. Kuester, 2007, Drug Metabolism and Disposition.

RIFM fragrance ingredient safety assessment, 2-trans-6-cis-dodecadienal, CAS Registry Number 21662-13-5.

G. A. Burton, T. Schultz, D. Liebler, 2021, Food and Chemical Toxicology.

RIFM fragrance ingredient safety assessment, 2,6-octadienal, (2E,6Z)-, CAS registry number 76917-23-2.

G. A. Burton, T. Schultz, D. Liebler, 2021, Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association.

RIFM fragrance ingredient safety assessment, 2,7-decadienal, (2E,7Z)-, CAS Registry Number 52711-52-1.

G. A. Burton, T. Schultz, D. Liebler, 2021, Food and Chemical Toxicology.

RIFM fragrance ingredient safety assessment, 2,7-nonadienal, (2E,7Z)-, CAS Registry Number 21662-22-6.

G. A. Burton, T. Schultz, D. Liebler, 2021, Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association.

RIFM fragrance ingredient safety assessment, 5-Acetyl-3-isopropyl-1,1,2,6-tetramethylindane, CAS Registry Number 68140-48-7.

A. M. Api, G. A. Burton, P. Calow, 2017, Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association.

RIFM fragrance ingredient safety assessment, 1-(1,2,3,4-tetrahydro-4,4-dimethyl-1-naphthyl)propan-1-one, CAS Registry Number 74499-60-8.

A. M. Api, P. Calow, T. Schultz, 2016, Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association.

A relationship between the metabolism of bumetanide and its diuretic activity in the rat.

D. E. Carter, I. Sipes, S. Halladay, 1978, Drug metabolism and disposition: the biological fate of chemicals.

Tissue distribution and elimination of indium in male Fischer 344 rats following oral and intratracheal administration of indium phosphide.

D. E. Carter, S. Winter, I. Sipes, 1994, Journal of toxicology and environmental health.

Update to RIFM fragrance ingredient safety assessment, fenchyl alcohol, CAS Registry Number 1632-73-1.

A. M. Api, G. A. Burton, T. Schultz, 2022, Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association.

RIFM fragrance ingredient safety assessment, 2-tert-butylcyclohexanol, CAS Registry Number 13491-79-7.

A. M. Api, P. Calow, T. Schultz, 2017, Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association.

RIFM fragrance ingredient safety assessment, Fenchyl alcohol, CAS registry number 1632-73-1.

A. M. Api, P. Calow, T. Schultz, 2015, Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association.

RIFM fragrance ingredient safety assessment, l-Borneol, CAS registry number 464-45-9.

A. M. Api, P. Calow, T. Schultz, 2015, Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association.

Sensitive gas chromatographic determination of trifluoperazine in human plasma.

I. Sipes, T. Gillespie, 1981, Journal of chromatography.

RIFM fragrance ingredient safety assessment, isocyclocitral, CAS Registry number 1335-66-6.

G. A. Burton, T. Schultz, D. Liebler, 2019, Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association.

1,2-Dichlorobenzene-mediated hepatocellular oxidative stress in Fischer-344 and Sprague-Dawley rats.

I. Sipes, N. Hoglen, L. Gunawardhana, 2000, Toxicology and applied pharmacology.

Time Course of Hepatic Injury and Recovery Following Coadministration of Carbon Tetrachloride and Trichloroethylene in Fischer-344 Rats

I. Sipes, P. Hall, D. A. Mcmillan, 1993, Toxicologic pathology.

RIFM fragrance ingredient safety assessment, hexanoic acid, CAS Registry Number 142-62-1.

A. M. Api, G. A. Burton, T. Schultz, 2020, Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association.

RIFM fragrance ingredient safety assessment, γ-decalactone, CAS Registry Number 706-14-9.

G. A. Burton, T. Schultz, D. Liebler, 2019, Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association.

RIFM fragrance ingredient safety assessment, γ-heptalactone, CAS Registry Number 105-21-5.

G. A. Burton, T. Schultz, D. Liebler, 2019, Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association.

RIFM fragrance ingredient safety assessment, piperidine, CAS Registry Number 110-89-4.

G. A. Burton, T. Schultz, D. Liebler, 2022, Food and Chemical Toxicology.

Update to RIFM fragrance ingredient safety assessment, benzyl butyrate, CAS Registry Number 103-37-7.

A. M. Api, G. A. Burton, T. Schultz, 2022, Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association.

RIFM fragrance ingredient safety assessment, phenethyl acetate, CAS Registry Number 103-45-7.

A. M. Api, G. A. Burton, T. Schultz, 2022, Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association.

RIFM fragrance ingredient safety assessment 2,4-dimethylbenzyl acetate, CAS Registry Number 62346-96-7.

A. M. Api, G. A. Burton, T. Schultz, 2018, Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association.

RIFM fragrance ingredient safety assessment, 4-methylbenzyl acetate, CAS Registry Number 2216-45-7.

A. M. Api, P. Calow, T. Schultz, 2016, Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association.

RIFM fragrance ingredient safety assessment, benzyl isobutyrate, CAS Registry Number 103-28-6.

A. M. Api, T. W. Schultz, P. Calow, 2016, Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association.

RIFM fragrance ingredient safety assessment, p-Isopropylbenzyl acetate, CAS Registry Number 59230-57-8.

A. M. Api, P. Calow, T. Schultz, 2016, Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association.

RIFM fragrance ingredient safety assessment, benzyl butyrate, CAS Registry Number 103-37-7.

A. M. Api, P. Calow, T. Schultz, 2016, Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association.

RIFM fragrance ingredient safety assessment, Benzyl propionate, CAS Registry Number 122-63-4.

A. M. Api, P. Calow, T. Schultz, 2016, Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association.

RIFM fragrance ingredient safety assessment, Benzyl acetate, CAS Registry Number 140-11-4.

A. M. Api, T. W. Schultz, P. Calow, 2015, Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association.

RIFM fragrance ingredient safety assessment, hexyl hexanoate, CAS Registry Number 6378-65-0.

G. A. Burton, T. Schultz, D. Liebler, 2020, Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association.

RIFM fragrance ingredient safety assessment, (4-tert-butylphenyl)acetonitrile, CAS Registry Number 3288-99-1.

G. A. Burton, T. Schultz, D. Liebler, 2022, Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association.

RIFM fragrance ingredient safety assessment, benzonitrile, CAS Registry Number 100-47-0.

G. A. Burton, T. Schultz, D. Liebler, 2021, Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association.

RIFM fragrance ingredient safety assessment, p-methoxybenzonitrile, CAS Registry Number 874-90-8.

G. A. Burton, P. Calow, T. Schultz, 2017, Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association.

RIFM fragrance ingredient safety assessment, cuminyl nitrile, CAS Registry Number 13816-33-6.

G. A. Burton, P. Calow, T. Schultz, 2017, Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association.

RIFM fragrance ingredient safety assessment, ethyl methacrylate, CAS Registry Number 97-63-2.

A. M. Api, G. A. Burton, T. Schultz, 2020, Food and Chemical Toxicology.

RIFM fragrance ingredient safety assessment, benzothiazole, CAS Registry Number 95-16-9.

G. A. Burton, T. Schultz, D. Liebler, 2018, Food and Chemical Toxicology.

Circadian alterations in prolactin, corticosterone, and thyroid hormone levels and down-regulation of prolactin receptor activity by 2,3,7,8-tetrachlorodibenzo-p-dioxin.

I. Sipes, M. K. Jones, D. Russell, 1987, Toxicology and applied pharmacology.

RIFM fragrance ingredient safety assessment, geraniol, CAS registry number 106-24-1.

G. A. Burton, T. Schultz, D. Liebler, 2022, Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association.

RIFM fragrance ingredient safety assessment, coumarin, CAS Registry Number 91-64-5.

G. A. Burton, T. Schultz, D. Liebler, 2019, Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association.

RIFM fragrance ingredient safety assessment, ethylene brassylate, CAS Registry Number 105-95-3.

G. A. Burton, T. Schultz, D. Liebler, 2016, Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association.

RIFM fragrance ingredient safety assessment, α-amylcinnamaldehyde, CAS registry number 122-40-7.

A. M. Api, Terry W. Schultz, P. Calow, 2015, Food and Chemical Toxicology.

Quantitative analysis of volatile halothane metabolites in biological tissues by gas chromatography.

A. J. Gandolfi, I. Sipes, B. R. Brown, 1979, Journal of chromatography.

RIFM fragrance ingredient safety assessment, xylene (mixed), CAS Registry Number 1330-20-7.

A. M. Api, G. A. Burton, T. Schultz, 2021, Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association.

RIFM fragrance ingredient safety assessment,2-methyl-2-propanol, CAS registry number 75-65-0.

G. A. Burton, T. Schultz, D. Liebler, 2022, Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association.

RIFM fragrance ingredient safety assessment, butyl lactate, CAS Registry Number 138-22-7.

A. M. Api, G. A. Burton, T. Schultz, 2021, Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association.

RIFM fragrance ingredient safety assessment, cinnamyl acetate, CAS Registry Number 103-54-8.

A. M. Api, G. A. Burton, T. Schultz, 2021, Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association.

RIFM fragrance ingredient safety assessment, cinnamyl propionate, CAS Registry Number 103-56-0.

A. M. Api, G. A. Burton, T. Schultz, 2021, Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association.

RIFM fragrance ingredient safety assessment, cinnamyl butyrate, CAS Registry Number 103-61-7.

A. M. Api, G. A. Burton, T. Schultz, 2021, Food and Chemical Toxicology.

RIFM fragrance ingredient safety assessment, cinnamyl isobutyrate, CAS Registry Number 103-59-3.

A. M. Api, G. A. Burton, T. Schultz, 2021, Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association.

RIFM fragrance ingredient safety assessment, cinnamyl formate, CAS Registry Number 104-65-4.

A. M. Api, G. A. Burton, T. Schultz, 2021, Food and Chemical Toxicology.

RIFM fragrance ingredient safety assessment, formic acid, CAS Registry Number 64-18-6.

G. A. Burton, T. Schultz, D. Liebler, 2020, Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association.

RIFM fragrance ingredient safety assessment, butyl methacrylate, CAS Registry Number 97-88-1.

A. M. Api, G. A. Burton, T. Schultz, 2020, Food and Chemical Toxicology.

RIFM fragrance ingredient safety assessment, n-hexyl 2-butenoate, CAS Registry Number 19089-92-0.

G. A. Burton, T. Schultz, D. Liebler, 2020, Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association.

Absorption, disposition, and metabolism of trans-methyl styryl ketone in female B6C3F1 mice.

I. Sipes, J. Sauer, R. Kuester, 1997, Drug metabolism and disposition: the biological fate of chemicals.

The disposition of acrylic acid in the male Sprague-Dawley rat following oral or topical administration.

S. Winter, I. Sipes, 1993, Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association.

Effect of O2 tension on the bioactivation and metabolism of aliphatic halides by primary rat-hepatocyte cultures.

A. J. Gandolfi, I. Sipes, J. Byard, 1984, Xenobiotica; the fate of foreign compounds in biological systems.

RIFM fragrance ingredient safety assessment, trans-2-Hexenol, CAS Registry Number 928-95-0.

G. A. Burton, T. Schultz, D. Liebler, 2018, Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association.

RIFM fragrance ingredient safety assessment, p-tolualdehyde, CAS Registry Number 104-87-0.

A. M. Api, G. A. Burton, T. Schultz, 2021, Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association.

RIFM fragrance ingredient safety assessment, 4-ethylbenzaldehyde, CAS Registry Number 4748-78-1.

A. M. Api, G. A. Burton, T. Schultz, 2020, Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association.

RIFM fragrance ingredient safety assessment, cuminic aldehyde, CAS Registry Number 122-03-2.

A. M. Api, G. A. Burton, T. Schultz, 2020, Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association.

Epoxidation of 4-vinylcyclohexene by human hepatic microsomes.

I. Sipes, B. J. Smith, 1991, Toxicology and applied pharmacology.

RIFM fragrance ingredient safety assessment, menthol, CAS Registry Number 89-78-1.

G. A. Burton, T. Schultz, D. Liebler, 2022, Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association.

RIFM fragrance ingredient safety assessment, terpinolene, CAS Registry Number 586-62-9.

G. A. Burton, T. Schultz, D. Liebler, 2022, Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association.

RIFM fragrance ingredient safety assessment, p-mentha-1,3-diene, CAS Registry Number 99-86-5

A. M. Api, G. A. Burton, T. Schultz, 2021, Food and Chemical Toxicology.

RIFM fragrance ingredient safety assessment, p-cymene, CAS Registry Number 99-87-6.

A. M. Api, G. A. Burton, T. Schultz, 2021, Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association.

The metabolism of xenobiotics and endogenous compounds by the constitutive dog liver cytochrome P450 PBD-2.

D. B. Duignan, J. Halpert, I. Sipes, 1988, Archives of biochemistry and biophysics.

Comparison of 2,2',4,4',5,5'-hexachloro[14C]biphenyl levels in different adipose tissues of dogs and monkeys.

D. E. Carter, I. Sipes, B. Ryerson, 1984, Fundamental and applied toxicology : official journal of the Society of Toxicology.

Initiation of delayed ovotoxicity by in vitro and in vivo exposures of rat ovaries to 4-vinylcyclohexene diepoxide.

P. Hoyer, I. Sipes, P. Devine, 2004, Reproductive toxicology.

A single dose of the ovotoxicant 4-vinylcyclohexene diepoxide is protective in rat primary ovarian follicles.

P. Hoyer, I. Sipes, S. Kao, 1999, Toxicology and applied pharmacology.

Assessment of follicle destruction in chemical-induced ovarian toxicity.

P. Hoyer, I. Sipes, I G Sipes, 1996, Annual review of pharmacology and toxicology.

RIFM fragrance ingredient safety assessment, dihydrocoumarin, CAS Registry Number 119-84-6.

G. A. Burton, T. Schultz, D. Liebler, 2021, Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association.

Introduction to the Liver: Functional Anatomy and Response to Toxicants ☆

R. McCuskey, J. Luyendyk, I. Sipes, 2018 .

Introduction to the Liver and its Response to Toxicants

R. McCuskey, I. Sipes, 2010 .

Obfuscating transparency?

G. B. Gori, H. Yamazaki, M. Aschner, 2018, Regulatory toxicology and pharmacology : RTP.

RIFM fragrance ingredient safety assessment, anisyl alcohol, CAS registry number 105-13-5.

G. A. Burton, T. Schultz, D. Liebler, 2019, Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association.

RIFM FRAGRANCE INGREDIENT SAFETY ASSESSMENT, Methyl jasmonate, CAS Registry Number 1211-29-6.

G. A. Burton, P. Calow, T. Schultz, 2017, Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association.

RIFM fragrance ingredient safety assessment phenethyl isovalerate, CAS Registry Number 140-26-1.

G. A. Burton, T. Schultz, D. Liebler, 2018, Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association.

Mechanisms of ovotoxicity induced by environmental chemicals: 4-vinylcyclohexene diepoxide as a model chemical.

P. Hoyer, I. Sipes, E. Cannady, 2001, Advances in experimental medicine and biology.

Examination of the differential hepatotoxicity of diallyl phthalate in rats and mice.

D. E. Carter, I. Sipes, K. Schram, 1986, Toxicology and applied pharmacology.

Capsaicinoid-induced local and systemic antinociception without substance P depletion

Thomas F. Burks, T. Burks, I. Sipes, 1982, Brain Research.

RIFM fragrance ingredient safety assessment, 3,7-dimethyloct-1-en-3-ol, CAS Registry Number 18479-49-7.

G. A. Burton, T. Schultz, D. Liebler, 2022, Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association.

RIFM fragrance ingredient safety assessment, citronellyl acetate, CAS Registry Number 150-84-5.

G. A. Burton, T. Schultz, D. Liebler, 2021, Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association.

RIFM fragrance ingredient safety assessment, 3,7-dimethyl-1,3,6-octatriene, CAS Registry Number 13877-91-3.

A. M. Api, G. A. Burton, T. Schultz, 2021, Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association.

RIFM fragrance ingredient safety assessment, myrcene, CAS Registry Number 123-35-3.

A. M. Api, G. A. Burton, T. Schultz, 2020, Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association.

RIFM fragrance ingredient safety assessment, γ-hexalactone, CAS Registry Number 695-06-7.

G. A. Burton, T. Schultz, D. Liebler, 2022, Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association.

RIFM fragrance ingredient safety assessment, 2-hexenoic acid, 2-methyl-, methyl ester, (2E)-, CAS Registry Number 16493-96-2.

G. A. Burton, T. Schultz, D. Liebler, 2021, Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association.

RIFM fragrance ingredient safety assessment, 4-pentenoic acid, 2-acetyl-4-methyl-, ethyl ester, CAS Registry Number 20962-70-3.

G. A. Burton, T. Schultz, D. Liebler, 2018, Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association.

RIFM fragrance ingredient safety assessment, p-cresyl salicylate, CAS Registry Number 607-88-5.

G. A. Burton, T. Schultz, D. Liebler, 2020, Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association.

RIFM fragrance ingredient safety assessment, isodecyl acetate, CAS Registry Number 69103-24-8.

G. A. Burton, T. Schultz, D. Liebler, 2022, Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association.

RIFM fragrance ingredient safety assessment, ethyl isovalerate, CAS Registry Number 108-64-5

G. A. Burton, T. Schultz, D. Liebler, 2021, Food and Chemical Toxicology.

RIFM fragrance ingredient safety assessment, 2-methylpropyl pentanoate, CAS Registry Number 10588-10-0.

G. A. Burton, T. Schultz, D. Liebler, 2020, Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association.

RIFM fragrance ingredient safety assessment, pentanoic acid, 2-methylbutyl ester, CAS Registry Number 55590-83-5.

A. M. Api, G. A. Burton, T. Schultz, 2020, Food and Chemical Toxicology.

RIFM fragrance ingredient safety assessment, isobutyl formate, CAS Registry Number 542-55-2.

G. A. Burton, T. Schultz, D. Liebler, 2020, Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association.

RIFM fragrance ingredient safety assessment, 2-ethylbutyl acetate, CAS Registry Number 10031-87-5.

A. M. Api, G. A. Burton, T. Schultz, 2019, Food and Chemical Toxicology.

Rifm fragrance ingredient safety assessment, 2-methylpentyl 2-methylvalerate, CAS Registry Number 90397-38-9.

G. A. Burton, T. Schultz, D. Liebler, 2019, Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association.

RIFM fragrance ingredient safety assessment, 2-ethylhexyl acetate, CAS Registry Number 103-09-3.

G. A. Burton, T. Schultz, D. Liebler, 2018, Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association.

RIFM fragrance ingredient safety assessment, isobutyl benzoate, CAS registry number 120-50-3.

G. A. Burton, T. Schultz, D. Liebler, 2018, Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association.

RIFM fragrance ingredient safety assessment, acetic acid, C7-9-branched alkyl esters, C8-rich, CAS Registry Number 108419-32-5.

G. A. Burton, P. Calow, T. Schultz, 2017, Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association.

RIFM fragrance ingredient safety assessment, 3-methylbutyl valerate, CAS Registry Number 2050-09-1.

G. A. Burton, P. Calow, T. Schultz, 2017, Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association.

RIFM fragrance ingredient safety assessment, Isoamyl butyrate, CAS Registry Number 106-27-4.

A. M. Api, G. A. Burton, P. Calow, 2017, Food and Chemical Toxicology.

Update to RIFM fragrance ingredient safety assessment, 3-methylbutyl 2-methylpropanoate, CAS Registry Number 2050-01-3.

A. M. Api, G. A. Burton, T. W. Schultz, 2022, Food and Chemical Toxicology.

RIFM fragrance ingredient safety assessment, 3,7-dimethyl-1-octanyl acetate, CAS Registry Number 20780-49-8.

G. A. Burton, P. Calow, T. Schultz, 2017, Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association.

RIFM fragrance ingredient safety assessment, isoamyl formate, CAS Registry Number 110-45-2.

G. A. Burton, P. Calow, T. Schultz, 2017, Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association.

RIFM fragrance ingredient safety assessment, isoamyl propionate, CAS Registry Number 105-68-0.

G. A. Burton, P. Calow, T. Schultz, 2017, Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association.

Update to RIFM fragrance ingredient safety assessment, isoamyl octanoate, CAS registry number 2035-99-6.

A. M. Api, G. A. Burton, T. Schultz, 2023, Food and Chemical Toxicology.

RIFM fragrance ingredient safety assessment, isobutyl hexanoate, CAS Registry Number 105-79-3.

G. A. Burton, T. Schultz, D. Liebler, 2019, Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association.

Diuretic effect and metabolism of bumetanide in man

D. E. Carter, I. Sipes, S. Halladay, 1977, Clinical pharmacology and therapeutics.

RIFM fragrance ingredient safety assessment, 2,3-dihydro-1,1-dimethyl-1H-indene-ar-propanal, CAS Registry Number 300371-33-9.

A. M. Api, G. A. Burton, T. Schultz, 2022, Food and Chemical Toxicology.

RIFM fragrance ingredient safety assessment, linalyl anthranilate, CAS Registry Number 7149-26-0.

G. A. Burton, T. Schultz, D. Liebler, 2019, Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association.

RIFM fragrance ingredient safety assessment, 2-methyl-3-buten-2-ol, CAS Registry Number 115-18-4.

P. Calow, T. Schultz, D. Liebler, 2015, Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association.

Biotransformation activity in vitrified human liver slices.

A. J. Gandolfi, C. Putnam, I. Sipes, 1991, Cryobiology.

Metabolism of dichlorobenzenes in organ cultured liver slices.

I. Sipes, R. Hanzlik, R. Fisher, 1991, Advances in experimental medicine and biology.

Reduction of thyroid hormone may participate in the modulation of cytochromes P450 2C11 and 3A2 by retinol.

J. Halpert, I. Sipes, J. Kraner, 1998, Life sciences.

Comparative metabolism and toxicity of dichlorobenzenes in Sprague-Dawley, Fischer-344 and human liver slices

A. J. Gandolfi, I. Sipes, R. Fisher, 1995, Human & experimental toxicology.

Differential induction of DNA strand breaks by nitrosamines in the rat liver and esophagus.

I. Sipes, S. Mufti, 1988, Cancer letters.

A toxicologic and dermatologic assessment of cinnamyl phenylpropyl materials when used as fragrance ingredients.

J. Saurat, P. Calow, H. Greim, 2011, Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association.

RIFM fragrance ingredient safety assessment, Isoborneol, CAS Registry Number 124-76-5.

A. M. Api, Terry W. Schultz, P. Calow, 2015, Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association.

RIFM FRAGRANCE INGREDIENT SAFETY ASSESSMENT, 6-acetyl-1,1,2,4,4,7-hexamethyltetraline, CAS Registry Number 21145-77-7.

G. A. Burton, P. Calow, T. Schultz, 2017, Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association.

RIFM fragrance ingredient safety assessment, 3-phenyl-1-propanol, CAS Registry Number 122-97-4.

A. M. Api, G. A. Burton, T. Schultz, 2022, Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association.

RIFM fragrance ingredient safety assessment, sodium benzoate, CAS Registry Number 532-32-1.

A. M. Api, G. A. Burton, T. Schultz, 2021, Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association.

RIFM fragrance ingredient safety assessment, 4-phenyl-3-buten-2-ol, CAS Registry Number 17488-65-2.

A. M. Api, G. A. Burton, T. Schultz, 2020, Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association.

RIFM fragrance ingredient safety assessment, benzyl cinnamate, CAS Registry Number 103-41-3.

G. A. Burton, T. Schultz, D. Liebler, 2020, Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association.

RIFM fragrance ingredient safety assessment, cinnamyl alcohol, CAS Registry Number 104-54-1.

A. M. Api, G. A. Burton, S. Tsang, 2020, Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association.

RIFM fragrance ingredient safety assessment, hexyl phenylacetate, CAS Registry Number 5421-17-0.

A. M. Api, G. A. Burton, T. Schultz, 2019, Food and Chemical Toxicology.

RIFM fragrance ingredient safety assessment, isoamyl benzoate, CAS registry number 94-46-2.

A. M. Api, G. A. Burton, T. Schultz, 2019, Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association.

RIFM fragrance ingredient safety assessment, isoamyl phenylacetate, CAS Registry Number 102-19-2.

A. M. Api, G. A. Burton, T. Schultz, 2019, Food and Chemical Toxicology.

RIFM fragrance ingredient safety assessment, ethyl 3-phenylpropionate, CAS Registry Number 2021-28-5.

G. A. Burton, T. Schultz, D. Liebler, 2019, Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association.

RIFM fragrance ingredient safety assessment, ethyl benzoate, CAS Registry Number 93-89-0.

G. A. Burton, T. Schultz, D. Liebler, 2018, Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association.

RIFM fragrance ingredient safety assessment, methyl benzoate, CAS Registry Number 93-58-3.

G. A. Burton, T. Schultz, D. Liebler, 2018, Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association.

RIFM fragrance ingredient safety assessment, ethyl phenylacetate, CAS Registry Number 101-97-3.

G. A. Burton, T. Schultz, D. Liebler, 2018, Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association.

RIFM fragrance ingredient safety assessment, pentyl phenylacetate, CAS Registry Number 5137-52-0.

G. A. Burton, T. Schultz, D. Liebler, 2018, Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association.

RIFM fragrance ingredient safety assessment, pentyl benzoate, CAS Registry Number 2049-96-9.

A. M. Api, G. A. Burton, T. Schultz, 2018, Food and Chemical Toxicology.

RIFM fragrance ingredient safety assessment, methyl phenylacetate, CAS Registry Number 101-41-7.

A. M. Api, G. A. Burton, T. Schultz, 2018, Food and Chemical Toxicology.

RIFM fragrance ingredient safety assessment, hexyl benzoate, CAS Registry Number 6789-88-4.

A. M. Api, G. A. Burton, T. Schultz, 2018, Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association.

RIFM FRAGRANCE INGREDIENT SAFETY ASSESSMENT, Butyl phenylacetate, CAS Registry Number 122-43-0.

G. A. Burton, T. Schultz, D. Liebler, 2018, Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association.

RIFM fragrance ingredient safety assessment, isobutyl phenylacetate, CAS Registry Number 102-13-6.

G. A. Burton, T. Schultz, D. Liebler, 2019, Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association.

RIFM fragrance ingredient safety assessment, α-amylcinnamyl alcohol, CAS Registry Number 101-85-9.

G. A. Burton, T. Schultz, D. Liebler, 2019, Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association.

RIFM fragrance ingredient safety assessment, α-butylcinnamaldehyde, CAS Registry Number 7492-44-6.

A. M. Api, P. Calow, T. Schultz, 2015, Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association.

3,3',4,4'-tetrachloroazobenzene absorption, disposition, and metabolism in male Fischer 344 rats.

D. Liebler, I. Sipes, M. Mayersohn, 1996, Drug metabolism and disposition: the biological fate of chemicals.

RIFM fragrance ingredient safety assessment, 4-methyl-3-penten-2-one, CAS Registry Number 141-79-7.

A. M. Api, G. A. Burton, T. Schultz, 2020, Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association.

RIFM fragrance ingredient safety assessment, acetic acid, CAS Registry Number 64-19-7.

G. A. Burton, T. Schultz, D. Liebler, 2019, Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association.

RIFM fragrance ingredient safety assessment, acetal, CAS Registry Number 105-57-7.

G. A. Burton, T. Schultz, D. Liebler, 2018, Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association.

RIFM fragrance ingredient safety assessment, nerol, CAS Registry Number 106-25-2.

G. A. Burton, T. Schultz, D. Liebler, 2023, Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association.

RIFM fragrance ingredient safety assessment, methyl butyrate, CAS registry number 623-42-7.

G. A. Burton, T. Schultz, D. Liebler, 2022, Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association.

RIFM fragrance ingredient safety assessment, ethyl acetate, CAS Registry Number 141-78-6.

G. A. Burton, T. Schultz, D. Liebler, 2022, Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association.

RIFM fragrance ingredient safety assessment, propyl acetate, CAS Registry Number 109-60-4.

G. A. Burton, T. Schultz, D. Liebler, 2022, Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association.

RIFM fragrance ingredient safety assessment, p-methoxybenzaldehyde, CAS Registry Number 123-11-5.

G. A. Burton, T. Schultz, D. Liebler, 2022, Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association.

RIFM fragrance ingredient safety assessment, 2-methoxy-4-vinylphenol, CAS Registry Number 7786-61-0.

G. A. Burton, T. Schultz, D. Liebler, 2022, Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association.

RIFM fragrance ingredient safety assessment, α-methylcinnamic alcohol, CAS Registry Number 1504-55-8.

A. M. Api, G. A. Burton, T. Schultz, 2021, Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association.

RIFM fragrance ingredient safety assessment, isobutyl cinnamate, CAS Registry Number 122-67-8.

G. A. Burton, T. Schultz, D. Liebler, 2021, Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association.

RIFM fragrance ingredient safety assessment, isoamyl cinnamate, CAS Registry Number 7779-65-9.

G. A. Burton, T. Schultz, D. Liebler, 2021, Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association.

RIFM fragrance ingredient safety assessment, γ-undecalactone, CAS Registry Number 104-67-6.

G. A. Burton, T. Schultz, D. Liebler, 2020, Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association.

RIFM fragrance ingredient safety assessment, p-mentha-1,8-dien-7-al, CAS Registry Number 2111-75-3.

G. A. Burton, T. Schultz, D. Liebler, 2019, Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association.

RIFM fragrance ingredient safety assessment, isoamyl hexanoate, CAS Registry Number 2198-61-0.

G. A. Burton, P. Calow, T. Schultz, 2017, Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association.

RIFM fragrance ingredient safety assessment, 2-tridecanone, CAS Registry Number 593-08-8.

G. A. Burton, T. Schultz, D. Liebler, 2022, Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association.

RIFM fragrance ingredient safety assessment, 2-pentadecanone, CAS Registry Number 2345-28-0.

G. A. Burton, T. Schultz, D. Liebler, 2022, Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association.

RIFM fragrance ingredient safety assessment, 3-methyl-1-pentanol, CAS Registry Number 589-35-5.

A. M. Api, G. A. Burton, T. Schultz, 2017, Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association.

RIFM fragrance ingredient safety assessment, 3,7-dimethyl-1-octanol, CAS Registry Number 106-21-8.

G. A. Burton, T. Schultz, D. Liebler, 2017, Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association.

RIFM FRAGRANCE INGREDIENT SAFETY ASSESSMENT, 2-Methylbutanol, CAS Registry Number 137-32-6.

P. Calow, T. Schultz, D. Liebler, 2017, Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association.

RIFM fragrance ingredient safety assessment, 3-methyl-1-cyclopentadecanone, CAS Registry Number 541-91-3.

G. A. Burton, T. Schultz, D. Liebler, 2021, Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association.

RIFM fragrance ingredient safety assessment, cinnamyl benzoate, CAS Registry Number 5320-75-2.

G. A. Burton, T. Schultz, D. Liebler, 2020, Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association.

RIFM fragrance ingredient safety assessment, p,α-dimethylstyrene, CAS Registry Number 1195-32-0.

G. A. Burton, T. Schultz, D. Liebler, 2022, Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association.

RIFM fragrance ingredient safety assessment, myrcenol, CAS Registry Number 543-39-5.

G. A. Burton, T. Schultz, D. Liebler, 2020, Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association.

RIFM fragrance ingredient safety assessment, isobutyl salicylate, CAS Registry Number 87-19-4.

G. A. Burton, T. Schultz, D. Liebler, 2023, Food and Chemical Toxicology.

RIFM fragrance ingredient safety assessment, (Z)-5-(3-hexenyl)dihydrofuran-2(3H)-one, CAS Registry Number 63095-33-0.

G. A. Burton, T. Schultz, D. Liebler, 2023, Food and Chemical Toxicology.

RIFM fragrance ingredient safety assessment, 5,6,7,8-tetrahydroquinoxaline, CAS registry number 34413-35-9.

G. A. Burton, T. Schultz, D. Liebler, 2023, Food and Chemical Toxicology.

RIFM fragrance ingredient safety assessment, sssmenthadiene-7-methyl formate, CAS registry number 68683-20-5.

G. A. Burton, T. Schultz, D. Liebler, 2023, Food and Chemical Toxicology.

Update to RIFM fragrance ingredient safety assessment, propyl phenethyl acetal, CAS registry number 7493-57-4.

G. A. Burton, T. Schultz, D. Liebler, 2023, Food and Chemical Toxicology.

RIFM fragrance ingredient safety assessment, 2,4-hexadienyl isobutyrate, CAS Registry number 16491-24-0.

G. A. Burton, T. Schultz, D. Liebler, 2023, Food and Chemical Toxicology.

RIFM fragrance ingredient safety assessment, 6,6-dimethoxy-2,5,5-trimethylhex-2-ene, CAS registry number 67674-46-8.

G. A. Burton, T. Schultz, D. Liebler, 2023, Food and Chemical Toxicology.

RIFM fragrance ingredient safety assessment, ethyl p-anisate, CAS registry number 94-30-4.

G. A. Burton, T. Schultz, D. Liebler, 2023, Food and Chemical Toxicology.

RIFM fragrance ingredient safety assessment, diphenylmethane, CAS Registry Number 101-81-5.

G. A. Burton, T. Schultz, D. Liebler, 2023, Food and Chemical Toxicology.

RIFM fragrance ingredient safety assessment, 2-methyl-3-(1-oxopropoxy)-4H-pyran-4-one, CAS Registry Number 68555-63-5.

G. A. Burton, T. Schultz, D. Liebler, 2023, Food and Chemical Toxicology.

RIFM fragrance ingredient safety assessment, 2,6-dimethyl-10-methylene-2,6,11-dodecatrienal, CAS registry number 17909-77-2.

A. M. Api, G. A. Burton, T. Schultz, 2022, Food and Chemical Toxicology.

RIFM fragrance ingredient safety assessment, sclareolide, CAS Registry Number 564-20-5.

G. A. Burton, T. Schultz, D. Liebler, 2022, Food and Chemical Toxicology.

RIFM fragrance ingredient safety assessment, alcohols, C9-11-iso-, C10-rich, CAS Registry Number 68526-85-2.

G. A. Burton, T. Schultz, D. Liebler, 2022, Food and Chemical Toxicology.

RIFM FRAGRANCE INGREDIENT SAFETY ASSESSMENT, propyl phenethyl acetal, CAS Registry Number 7493-57-4.

G. A. Burton, T. Schultz, D. Liebler, 2017, Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association.

Stereochemical aspects of vinylcyclohexene bioactivation in rodent hepatic microsomes and purified human cytochrome P450 enzyme systems.

P. Hoyer, I. Sipes, E. Mash, 2001, Drug metabolism and disposition: the biological fate of chemicals.

RIFM fragrance ingredient safety assessment, cyclopentadecanone, CAS Registry Number 502-72-7.

G. A. Burton, T. Schultz, D. Liebler, 2021, Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association.

RIFM fragrance ingredient safety assessment, 6,7-dihydro-1,1,2,3,3-pentamethyl-4(5H)-indanone, CAS Registry Number 33704-61-9.

G. A. Burton, T. Schultz, D. Liebler, 2020, Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association.

RIFM fragrance ingredient safety assessment, ω-pentadecalactone, CAS Registry Number 106-02-5.

G. A. Burton, T. Schultz, D. Liebler, 2020, Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association.

Update to RIFM fragrance ingredient safety assessment, 1-(1,2,3,4-tetrahydro-4,4-dimethyl-1-naphthyl)propan-1-one, CAS Registry Number 74499-60-8.

G. A. Burton, T. Schultz, D. Liebler, 2022, Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association.

RIFM fragrance ingredient safety assessment, δ-3-carene, CAS Registry Number 13466-78-9.

G. A. Burton, T. Schultz, D. Liebler, 2018, Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association.

RIFM fragrance ingredient safety assessment, 2-hexylidenecyclohexan-1-one, CAS Registry Number 16429-07-5.

A. M. Api, G. A. Burton, T. Schultz, 2021, Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association.

RIFM fragrance ingredient safety assessment, methyl 2-nonenoate, CAS Registry Number 111-79-5.

A. M. Api, G. A. Burton, S. Tsang, 2019, Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association.

RIFM fragrance ingredient safety assessment, methyl 2-octynoate, CAS Registry Number 111-12-6.

A. M. Api, G. A. Burton, T. Schultz, 2019, Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association.

Biliary excretion of metabolities of bromobenzene.

I. Sipes, G. Krishna, P. Gigon, 1974, Biochemical pharmacology.

RIFM fragrance ingredient safety assessment, bicyclo[3.1.0]hexan-3-one, 4-methyl-1-(1-methylethyl)-, CAS Registry Number 1125-12-8.

A. M. Api, D. Liebler, W. Dekant, 2019, Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association.

Effect of phosphatidylinositol-3 kinase inhibition on ovotoxicity caused by 4-vinylcyclohexene diepoxide and 7, 12-dimethylbenz[a]anthracene in neonatal rat ovaries.

P. Hoyer, A. Keating, Nivedita Sen, 2009, Toxicology and applied pharmacology.

Differential ovotoxicity of 4-vinylcyclohexene and its analog, 4-phenylcyclohexene.

I. Sipes, S. Hooser, L. Parola, 1993, Toxicology and Applied Pharmacology.

RIFM fragrance ingredient safety assessment, 2-methyl-3-(p-isopropylphenyl)propionaldehyde, CAS Registry Number 103-95-7.

A. M. Api, S. Tsang, Terry W. Schultz, 2020, Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association.

RIFM fragrance ingredient safety assessment, isobornyl propionate, CAS Registry Number 2756-56-1.

A. M. Api, P. Calow, D. Liebler, 2016, Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association.

RIFM fragrance ingredient safety assessment, isobornyl isovalerate, CAS registry number 7779-73-9.

A. M. Api, P. Calow, D. Liebler, 2017, Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association.

RIFM fragrance ingredient safety assessment, 5-Ethylidenebicyclo[2.2.1]hept-2-yl propionate, CAS Registry Number 73347-77-0.

A. M. Api, P. Calow, D. Liebler, 2017, Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association.

RIFM fragrance ingredient safety assessment, Isobornyl 2-methylpropionate, CAS Registry Number 85586-67-0.

A. M. Api, P. Calow, D. Liebler, 2017, Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association.

RIFM fragrance ingredient safety assessment, 1,3,3-trimethyl-2-norbornanyl acetate, CAS registry number 13851-11-1.

A. M. Api, P. Calow, D. Liebler, 2016, Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association.

Dichlorobenzene hepatotoxicity strain differences and structure activity relationships.

I. Sipes, L. Gunawardhana, 1991, Advances in Experimental Medicine and Biology.

The RIFM approach to evaluating Natural Complex Substances (NCS).

A. M. Api, D. Liebler, W. Dekant, 2021, Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association.

RIFM fragrance ingredient safety assessment, cinnamic acid, CAS Registry Number 621-82-9.

A. M. Api, D. Liebler, W. Dekant, 2022, Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association.

RIFM fragrance ingredient safety assessment, amyl alcohol, CAS Registry Number 71-41-0.

A. M. Api, D. Liebler, W. Dekant, 2019, Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association.

RIFM natural complex substance (NCS) fragrance ingredient safety assessment, petitgrain Mandarin oil, CAS registry number 8014-17-3, RIFM ID: 250-E2.12.

A. M. Api, D. Liebler, W. Dekant, 2022, Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association.

Update to RIFM fragrance ingredient safety assessment, borneol, CAS Registry Number 507-70-0.

A. M. Api, D. Liebler, W. Dekant, 2022, Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association.

RIFM fragrance ingredient safety assessment, longifolene, CAS Registry Number 475-20-7.

A. M. Api, D. Liebler, W. Dekant, 2019, Food and Chemical Toxicology.

RIFM fragrance ingredient safety assessment, glyceryl monooleate, CAS Registry Number 111-03-5.

A. M. Api, D. Liebler, W. Dekant, 2021, Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association.

RIFM fragrance ingredient safety assessment, α-methylcinnamaldehyde, CAS Registry Number 101-39-3.

A. M. Api, S. Tsang, Terry W. Schultz, 2019, Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association.

RIFM fragrance ingredient safety assessment, diphenyl ether, CAS Registry Number 101-84-8.

A. M. Api, S. Tsang, Terry W. Schultz, 2019, Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association.

Covalent adduct formation and chloroform production after free radical attack on fatty acids by carbon tetrachloride reactive intermediates.

M. Cunningham, I. Sipes, S. Chang, 1985, Toxicology.

653 – ISOLATION OF VOLATILE METABOLITES OF HALOTHANE FROM RAT LIVER

M. Cunningham, I. Sipes, B. R. Brown, 1978 .

RIFM fragrance ingredient safety assessment, lauric acid, CAS Registry Number 143-07-7.

A. M. Api, D. Liebler, W. Dekant, 2020, Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association.

Expression and activity of cytochromes P450 2E1, 2A, and 2B in the mouse ovary: the effect of 4-vinylcyclohexene and its diepoxide metabolite.

P. Hoyer, I. Sipes, P. Christian, 2003, Toxicological sciences : an official journal of the Society of Toxicology.

S. Wright, M. Hooth, I. Sipes, 2011, Drug Metabolism and Disposition.

Update to RIFM fragrance ingredient safety assessment, 4-carvomenthenol, CAS Registry Number 562-74-3.

A. M. Api, D. Liebler, W. Dekant, 2022, Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association.

Update to RIFM fragrance ingredient safety assessment, α-irone, CAS registry number 79-69-6.

A. M. Api, D. Liebler, W. Dekant, 2022, Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association.

RIFM fragrance ingredient safety assessment, allyl cyclohexanepropionate, CAS Registry Number 2705-87-5.

A. M. Api, D. Liebler, W. Dekant, 2021, Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association.

RIFM fragrance ingredient safety assessment, δ-undecalactone, CAS Registry Number 710-04-3.

A. M. Api, D. Liebler, W. Dekant, 2021, Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association.

RIFM fragrance ingredient safety assessment, pulegone, CAS Registry Number 89-82-7.

A. M. Api, D. Liebler, W. Dekant, 2021, Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association.

RIFM low-exposure fragrance ingredients safety assessment.

A. M. Api, D. Liebler, W. Dekant, 2021, Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association.

RIFM fragrance ingredient safety assessment, 2-hexanol, CAS Registry Number 626-93-7.

A. M. Api, D. Liebler, W. Dekant, 2020, Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association.

RIFM fragrance ingredient safety assessment, 2-phenylpropionaldehyde, CAS Registry Number 93-53-8.

A. M. Api, S. Tsang, D. Liebler, 2020, Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association.

RIFM fragrance ingredient safety assessment, butyrophenone, cas Registry Number 495-40-9.

A. M. Api, D. Liebler, W. Dekant, 2018, Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association.

RIFM fragrance ingredient safety assessment diethyl succinate, CAS Registry Number 123-25-1.

A. M. Api, D. Liebler, W. Dekant, 2017, Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association.

RIFM fragrance ingredient safety assessment, 3,6-nonadien-1-ol, CAS registry number 76649-25-7.

A. M. Api, D. Liebler, W. Dekant, 2017, Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association.

RIFM fragrance ingredient safety assessment, decanal dimethyl acetal, CAS Registry Number 7779-41-1.

A. M. Api, D. Liebler, W. Dekant, 2017, Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association.

RIFM fragrance ingredient safety assessment, menthyl acetate (isomer unspecified), CAS Registry Number 16409-45-3.

A. M. Api, D. Liebler, W. Dekant, 2017, Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association.

RIFM fragrance ingredient safety assessment, 3,7-dimethyl-2,6-nonadienenitrile, CAS Registry Number 61792-11-8.

A. M. Api, D. Liebler, W. Dekant, 2017, Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association.

RIFM fragrance ingredient safety assessment, 2-isopropyl-4-methylanisole, CAS Registry Number 31574-44-4.

A. M. Api, D. Liebler, W. Dekant, 2017, Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association.

RIFM fragrance ingredient safety assessment, menthyl isovalerate CAS Registry Number 16409-46-4.

A. M. Api, D. Liebler, W. Dekant, 2017, Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association.

RIFM fragrance ingredient safety assessment, 4-isopropyl-2-methoxy-1-methylbenzene, CAS Registry Number 6379-73-3.

A. M. Api, D. Liebler, W. Dekant, 2017, Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association.

RIFM fragrance ingredient safety assessment, dodecanenitrile, CAS Registry Number 2437-25-4.

A. M. Api, D. Liebler, W. Dekant, 2018, Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association.

RIFM fragrance ingredient safety assessment, acetic acid, (1-oxopropoxy)-, 1-(3,3-dimethylcyclohexyl)ethyl ester, CAS Registry Number 236391-76-7.

A. M. Api, D. Liebler, W. Dekant, 2020, Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association.

RIFM Fragrance Ingredient Safety Assessment, Butyl anthranilate, CAS Registry Number 7756-96-9.

A. M. Api, D. Liebler, W. Dekant, 2017, Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association.

A safety assessment of non-cyclic alcohols with unsaturated branched chain when used as fragrance ingredients: the RIFM expert panel.

J. Saurat, P. Calow, A. E. Rogers, 2010, Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association.

Update to RIFM fragrance ingredient safety assessment, α-amylcinnamaldehyde, CAS Registry Number 122-40-7.

A. M. Api, T. W. Schultz, W. Dekant, 2024, Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association.

Update to RIFM fragrance ingredient safety assessment, α-methylcinnamaldehyde, CAS Registry Number 101-39-3.

A. M. Api, T. W. Schultz, W. Dekant, 2023, Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association.

RIFM fragrance ingredient safety assessment, β-methylphenethyl alcohol, CAS Registry Number 1123-85-9.

A. M. Api, D. Liebler, W. Dekant, 2017, Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association.

Update to RIFM fragrance ingredient safety assessment, p-tolyl alcohol, CAS Registry Number 589-18-4.

A. M. Api, T. W. Schultz, W. Dekant, 2024, Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association.

Evaluation of ovotoxicity induced by 7, 12-dimethylbenz[a]anthracene and its 3,4-diol metabolite utilizing a rat in vitro ovarian culture system.

P. Hoyer, A. Keating, I. Sipes, 2009, Toxicology and Applied Pharmacology.

RIFM fragrance ingredient safety assessment, isoeugenol, CAS Registry Number 97-54-1.

A. M. Api, P. Calow, D. Liebler, 2016, Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association.

Effect of senescence on the bioactivation of aliphatic halides.

I. Sipes, J. Mcdougal, A. Direnzo, 1982, Research communications in chemical pathology and pharmacology.

Update to RIFM fragrance ingredient safety assessment, α,2,2,3-tetramethylcyclopent-3-ene-1-butyraldehyde, CAS Registry Number 65114-03-6.

A. M. Api, D. Liebler, W. Dekant, 2022, Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association.

Pharmacokinetics of o-nitroanisole in Fischer 344 rats.

D. E. Carter, I. Sipes, D. Perry, 1985, Drug metabolism and disposition: the biological fate of chemicals.

Update to RIFM fragrance ingredient safety assessment, butyric acid, CAS Registry Number 107-92-6.

A. M. Api, T. W. Schultz, W. Dekant, 2024, Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association.

Update to RIFM fragrance ingredient safety assessment, diethyl succinate, CAS Registry Number 123-25-1.

A. M. Api, D. Liebler, W. Dekant, 2023, Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association.

RIFM fragrance ingredient safety assessment, 2-ethylbutyric acid, CAS Registry Number 88-09-5.

A. M. Api, D. Liebler, W. Dekant, 2020, Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association.