S. Havelund

发表

Environmental and Health Assesment of Alternatives to Phthalates and to flexible PVC

M. Birkved, F. Stuer-Lauridsen, S. Mikkelsen, 2001 .

Design of the Novel Protraction Mechanism of Insulin Degludec, an Ultra-long-Acting Basal Insulin

U. Ribel, S. Havelund, T. Hoeg-Jensen, 2012, Pharmaceutical Research.

Self-association of long-acting insulin analogues studied by size exclusion chromatography coupled to multi-angle light scattering.

B. Vestergaard, S. Havelund, M. van de Weert, 2011, Journal of chromatography. B, Analytical technologies in the biomedical and life sciences.

Small angle X-ray scattering-based elucidation of the self-association mechanism of human insulin analogue lys(B29)(N(ε)ω-carboxyheptadecanoyl) des(B30).

B. Vestergaard, S. Havelund, M. van de Weert, 2013, Biochemistry.

Chemical Stability of Insulin. 2. Formation of Higher Molecular Weight Transformation Products During Storage of Pharmaceutical Preparations

P. Hougaard, S. Havelund, J. Brange, 1992, Pharmaceutical Research.

Ionization behavior of native and mutant insulins: pK perturbation of B13-Glu in aggregated species.

P. Hougaard, S. Havelund, N. Kaarsholm, 1990, Archives of biochemistry and biophysics.

Multivariate Analysis of Phenol in Freeze-Dried and Spray-Dried Insulin Formulations by NIR and FTIR

S. Havelund, L. Hovgaard, S. Bjerregaard, 2011, AAPS PharmSciTech.

Albumin binding of insulins acylated with fatty acids: characterization of the ligand-protein interaction and correlation between binding affinity and timing of the insulin effect in vivo.

U. Ribel, S. Havelund, J. Markussen, 1995, The Biochemical journal.

The Mechanism of Protraction of Insulin Detemir, a Long-Acting, Acylated Analog of Human Insulin

U. Ribel, S. Havelund, A. Vølund, 2004, Pharmaceutical Research.

Soluble, fatty acid acylated insulins bind to albumin and show protracted action in pigs

U. Ribel, S. Havelund, L. Schäffer, 1996, Diabetologia.

Conformational correlation and coupled motion between residue A21 and B25 side chain observed in crystal structures of insulin mutants at position A21.

S. Havelund, Z. Zeng, D. C. Wang, 2000, Biochimica et biophysica acta.

Effect of fatty acids and selected drugs on the albumin binding of a long-acting, acylated insulin analogue.

S. Havelund, J. Markussen, P. Kurtzhals, 1997, Journal of pharmaceutical sciences.

Chemical Stability of Insulin. 1. Hydrolytic Degradation During Storage of Pharmaceutical Preparations

J. Brange, S. Havelund, A. Vølund, 1992, Pharmaceutical Research.

Analysis of insulin allostery in solution and solid state with FTIR.

S. Havelund, M. van de Weert, L. Hovgaard, 2009, Journal of pharmaceutical sciences.

Insulin Compatibility with Polymer Materials Used in External Pump Infusion Systems

S. Havelund, J. Brange, J. Villumsen, 1988, Diabetic medicine : a journal of the British Diabetic Association.

Reversible insulin self-assembly under carbohydrate control.

S. Havelund, T. Hoeg-Jensen, J. Markussen, 2005, Journal of the American Chemical Society.

Investigation of the Physico-Chemical Properties that Enable Co-Formulation of Basal Insulin Degludec with Fast-Acting Insulin Aspart

U. Ribel, S. Havelund, T. Hoeg-Jensen, 2015, Pharmaceutical Research.

Insulins with built‐in glucose sensors for glucose responsive insulin release

S. Havelund, L. Schäffer, T. Hoeg-Jensen, 2005, Journal of peptide science : an official publication of the European Peptide Society.

Insulin pumps and insulin quality--requirements and problems.

J. Brange, S. Havelund, 2009, Acta medica Scandinavica. Supplementum.

Chemical and Thermal Stability of Insulin: Effects of Zinc and Ligand Binding to the Insulin Zinc-Hexamer

S. Frokjaer, S. Havelund, M. Weert, 2006, Pharmaceutical Research.

Crystal structure of a prolonged-acting insulin with albumin-binding properties.

J. Whittingham, S. Havelund, I. Jonassen, 1997, Biochemistry.

Neutral Insulin Solutions Physically Stabilized by Addition of Zn2+

J. Brange, S. Havelund, C. Kühl, 1986, Diabetic medicine : a journal of the British Diabetic Association.

Carbohydrate substitution of terminal amino groups: A novel approach to monomeric/dimeric, fast acting non-immunogenic insulin

U. Ribel, S. Havelund, K. H. Jørgensen, 1991 .

Albumin binding and time action of acylated insulins in various species.

U. Ribel, S. Havelund, J. Markussen, 1996, Journal of pharmaceutical sciences.

Thermal dissociation and unfolding of insulin.

S. Frokjaer, S. Havelund, M. van de Weert, 2005, Biochemistry.

Crystallographic and solution studies of N-lithocholyl insulin: a new generation of prolonged-acting human insulins.

A. Wilkinson, E. Dodson, C. Verma, 2004, Biochemistry.

Dihydrofurocoumarin glucosides from Angelica archangelica and Angelica silvestris

S. Havelund, O. Thastrup, J. Lemmich, 1983 .

Alanine Scanning Mutagenesis of Insulin*

Claus Kristensen, Svend Havelund, D. Steiner, 1997, The Journal of Biological Chemistry.

Prepro-leaders lacking N-linked glycosylation for secretory expression in the yeast Saccharomyces cerevisiae.

S. Havelund, P. Balschmidt, T. Kjeldsen, 1998, Protein expression and purification.

Synthetic leaders with potential BiP binding mediate high-yield secretion of correctly folded insulin precursors from Saccharomyces cerevisiae.

P. H. Hansen, S. Havelund, A. S. Andersen, 1997, Protein expression and purification.

Monomeric insulins obtained by protein engineering and their medical implications

J. Brange, U. Ribel, J. Brange, 1988, Nature.

Engineering stability of the insulin monomer fold with application to structure-activity relationships.

O. Olsen, S. Havelund, N. Kaarsholm, 1993, Biochemistry.

The potential immunogenicity of human insulin and insulin analogues evaluated in a transgenic mouse model

D. Weilguny, D. Bucchini, J. Jami, 1994, Diabetologia.

Ligand-controlled assembly of hexamers, dihexamers, and linear multihexamer structures by the engineered acylated insulin degludec.

S. Havelund, H. Strauss, G. Schluckebier, 2013, Biochemistry.

Design of the Novel Protraction Mechanism of Insulin Degludec, an Ultra-long-Acting Basal Insulin

U. Ribel, S. Havelund, T. Hoeg-Jensen, 2012, Pharmaceutical Research.

Investigation of the Physico-Chemical Properties that Enable Co-Formulation of Basal Insulin Degludec with Fast-Acting Insulin Aspart

U. Ribel, S. Havelund, T. Hoeg-Jensen, 2015, Pharmaceutical Research.

Biochemical and Physiological Properties of a Novel Series of Long-Acting Insulin Analogs Obtained by Acylation with Cholic Acid Derivatives

Svend Havelund, Thomas Hoeg-Jensen, Ib Jonassen, 2006, Pharmaceutical Research.

Adsorption of insulin on solid surfaces in relation to the surface properties of the monomeric and oligomeric forms

S. Havelund, T. Nylander, P. Nilsson, 1991 .

Time-resolved SAXS measurements facilitated by online HPLC buffer exchange.

Bente Vestergaard, Katrine Nørgaard Toft, Svend Havelund, 2010, Journal of synchrotron radiation.

The acylated insulin

S. Havelund, A. S. Andersen, J. Markussen, 1996 .

Secretory expression of human albumin domains in Saccharomyces cerevisiae and their binding of myristic acid and an acylated insulin analogue.

P. H. Hansen, S. Havelund, J. Markussen, 1998, Protein expression and purification.

Ligand-induced conformational change in the minimized insulin receptor.

S. Havelund, M. Dunn, N. Kaarsholm, 2000, Journal of molecular biology.

Quality by design - Spray drying of insulin intended for inhalation.

Svend Havelund, S. Havelund, M. van de Weert, 2008, European journal of pharmaceutics and biopharmaceutics : official journal of Arbeitsgemeinschaft fur Pharmazeutische Verfahrenstechnik e.V.

Ligand binding and thermostability of different allosteric states of the insulin zinc-hexamer.

S. Frokjaer, S. Havelund, M. van de Weert, 2006, Biochemistry.