M. Ascoli

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Characterization of several clonal lines of cultured Leydig tumor cells: gonadotropin receptors and steroidogenic responses.

M. Ascoli, 1981, Endocrinology.

The Leydig cell MEK/ERK pathway is critical for maintaining a functional population of adult Leydig cells and for fertility.

J. Charron, M. Ascoli, Soichi Yamashita, 2011, Molecular endocrinology.

Identification of two distinct structural motifs that, when added to the C-terminal tail of the rat LH receptor, redirect the internalized hormone-receptor complex from a degradation to a recycling pathway.

A. Bretscher, M. Ascoli, X. Liu, 2001, Molecular endocrinology.

Epidermal growth factor desensitizes the gonadotropin-responsive adenylyl cyclase in membranes isolated from MA-10 Leydig tumor cells and luteinized rat ovaries.

M. Ascoli, M. Hafez, 1990, Endocrinology.

Ca+2 is an inhibitor of adenylate cyclase in MA-10 Leydig tumor cells.

M. Ascoli, M. Pereira, D. Segaloff, 1988, Endocrinology.

Do alterations in follicular fluid proteases contribute to human infertility?

B. V. Van Voorhis, M. Ascoli, L. Cookingham, 2015, Journal of Assisted Reproduction and Genetics.

Activation of the lutropin/choriogonadotropin receptor in MA-10 cells leads to the tyrosine phosphorylation of the focal adhesion kinase by a pathway that involves Src family kinases.

K. Shiraishi, M. Ascoli, T. Mizutani, 2006, Molecular endocrinology.

Mutation of Individual Serine Residues in the C-terminal Tail of the Lutropin/Choriogonadotropin Receptor Reveal Distinct Structural Requirements for Agonist-induced Uncoupling and Agonist-induced Internalization*

J. Benovic, M. Ascoli, K. Nakamura, 1998, The Journal of Biological Chemistry.

The Association of Arrestin-3 with the Human Lutropin/Choriogonadotropin Receptor Depends Mostly on Receptor Activation Rather than on Receptor Phosphorylation*

C. Galet, M. Ascoli, L. Min, 2002, The Journal of Biological Chemistry.

Regulation of gonadotropin receptors and gonadotropin responses in a clonal strain of Leydig tumor cells by epidermal growth factor.

M. Ascoli, 1981, The Journal of biological chemistry.

On the mechanisms involved in the regulation of the cell-surface receptors for human choriogonadotropin and mouse epidermal growth factor in cultured Leydig tumor cells

M. Ascoli, C. E. Lloyd, C. Lloyd, 1983, The Journal of cell biology.

Anti-phosphotyrosine immunoprecipitation of phosphatidylinositol 3' kinase activity in different cell types after exposure to epidermal growth factor.

M. Ascoli, E. Miller, 1990, Biochemical and biophysical research communications.

Internalization and degradation of receptor-bound human choriogonadotropin in Leydig tumor cells. Fate of the hormone subunits.

M. Ascoli, 1982, The Journal of biological chemistry.

Conformational stability and self-association of zinc-free bovine insulin at neutral pH.

M. Ascoli, D. Puett, L. A. Holladay, 1977, Biochimica et biophysica acta.

p38 JAB1 Binds to the Intracellular Precursor of the Lutropin/Choriogonadotropin Receptor and Promotes Its Degradation*

Xuebo Liu, M. Ascoli, Shenghua Li, 2000, The Journal of Biological Chemistry.

Mutations of the Second Extracellular Loop of the Human Lutropin Receptor Emphasize the Importance of Receptor Activation and De-emphasize the Importance of Receptor Phosphorylation in Agonist-induced Internalization*

Xuebo Liu, M. Ascoli, Shenghua Li, 2001, The Journal of Biological Chemistry.

Seven Non-contiguous Intracellular Residues of the Lutropin/Choriogonadotropin Receptor Dictate the Rate of Agonist-induced Internalization and Its Sensitivity to Non-visual Arrestins*

Xuebo Liu, M. Ascoli, K. Nakamura, 2000, The Journal of Biological Chemistry.

Effect of activating and inactivating mutations on the phosphorylation and trafficking of the human lutropin/choriogonadotropin receptor.

M. Ascoli, L. Min, 2000, Molecular endocrinology.

Multiple Distant Amino Acid Residues Present in the Serpentine Region of the Follitropin Receptor Modulate the Rate of Agonist-induced Internalization*

M. Ascoli, H. Kishi, 2000, The Journal of Biological Chemistry.

The C-terminal tail of the rat lutropin/choriogonadotropin (CG) receptor independently modulates human (h)CG-induced internalization of the cell surface receptor and the lysosomal targeting of the internalized hCG-receptor complex.

M. Ascoli, M. Kishi, 2000, Molecular endocrinology.

A dileucine-based motif in the C-terminal tail of the lutropin/choriogonadotropin receptor inhibits endocytosis of the agonist-receptor complex.

M. Ascoli, K. Nakamura, 1999, Molecular pharmacology.

The Rate of Internalization of the Gonadotropin Receptors Is Greatly Affected by the Origin of the Extracellular Domain*

Xuebo Liu, M. Ascoli, K. Nakamura, 1999, The Journal of Biological Chemistry.

Role of G protein-coupled receptor kinases on the agonist-induced phosphorylation and internalization of the follitropin receptor.

J. Benovic, M. Ascoli, K. Nakamura, 1999, Molecular endocrinology.

Role of the rate of internalization of the agonist-receptor complex on the agonist-induced down-regulation of the lutropin/choriogonadotropin receptor.

C. Korgaonkar, M. Ascoli, K. Nakamura, 1999, Molecular endocrinology.

The slow rate of internalization of deglycosylated human chorionic gonadotropin is not due to its inability to stimulate cyclic adenosine monophosphate accumulation.

M. Ascoli, M. Sairam, S. Hoelscher, 1991, Endocrinology.

Chapter 9 Internalization of peptide hormones and hormone receptors

M. Ascoli, D. Segaloff, 1988 .

On the fates of receptor-bound ovine luteinizing hormone and human chorionic gonadotropin in cultured Leydig tumor cells. Demonstration of similar rates of internalization.

M. Ascoli, D. Segaloff, 1987, Endocrinology.

Functions and Regulation of Cell Surface Receptors in Cultured Leydig Tumor Cells

M. Ascoli, 1985 .

Regulation of Gonadotropin Receptors and Steroidogenic Responses in Cultured Leydig Tumor Cells

M. Ascoli, D. Freeman, 1984 .

The Gonadotropin Hormones and Their Receptors

M. Ascoli, D. Puett, 2009 .

The Gαq/11-provoked induction of Akr1c18 in murine luteal cells is mediated by phospholipase C

M. Ascoli, J. Kapfhamer, Courtney Waite, 2017, Molecular and Cellular Endocrinology.

Endocrine, Paracrine, and Autocrine Signaling Pathways That Regulate Ovulation

J. Richards, M. Ascoli, 2018, Trends in Endocrinology & Metabolism.

The metabolism of luteinizing hormone. plasma clearance, urinary excretion, and tissue uptake

M. Ascoli, D. Puett, R. Liddle, 1975, Molecular and Cellular Endocrinology.

Renal and hepatic lysosomal catabolism of luteinizing hormone

M. Ascoli, D. Puett, R. Liddle, 1976, Molecular and Cellular Endocrinology.

The low-density lipoprotein pathway of cultured Leydig tumor cells. Utilization of low-density lipoprotein-derived cholesterol for steroidogenesis.

M. Ascoli, D. Freeman, 1983, Biochimica et biophysica acta.

Intracellular uptake and catabolism of lutropin by testicular tissue in vivo

M. Ascoli, D. Puett, David Puett, 1977, FEBS letters.

The association of arrestin-3 with the follitropin receptor depends on receptor activation and phosphorylation

C. Galet, H. Krishnamurthy, M. Ascoli, 2003, Molecular and Cellular Endocrinology.

Activation of Gq/11 in the mouse corpus luteum is required for parturition.

M. Ascoli, Rachel B. Mejia, Courtney Waite, 2015, Molecular endocrinology.

12 – Regulation of Steroid Production in Adrenal, Gonadal, and Placental Tumor Cells

M. Ascoli, 1982 .

Studies on the source of cholesterol used for steroid biosynthesis in cultured Leydig tumor cells.

M. Ascoli, D. Freeman, 1982, The Journal of biological chemistry.

Effects of hypocholesterolemia and chronic hormonal stimulation on sterol and steroid metabolism in a Leydig cell tumor.

M. Ascoli, 1981, Journal of lipid research.

Degradation of receptor-bound human choriogonadotropin by murine Leydig tumor cells.

M. Ascoli, D. Puett, 1978, The Journal of biological chemistry.

On the optical activity of ionized tyrosyl residues in ovine lutropin.

M. Ascoli, D. N. Ward, B. Jirgensons, 1977, European Journal of Biochemistry.

Inhibition of choriogonadotropin-activated steroidogenesis in cultured Leydig tumor cells by the Rp diastereoisomer of adenosine 3',5'-cyclic phosphorothioate.

M. Ascoli, F. Eckstein, M. Pereira, 1987, The Journal of biological chemistry.

Phosphorylation of the lutropin/choriogonadotropin receptor facilitates uncoupling of the receptor from adenylyl cyclase and endocytosis of the bound hormone.

M. Ascoli, X. Liu, Z. Wang, 1997, Molecular endocrinology.

Epidermal growth factor stimulates production of progesterone in cultured human choriocarcinoma cells.

M. Ascoli, K. Speeg, D. Rabin, 1980, Endocrinology.

DEGRADATION OF RECEPTOR-BOUND HUMAN CHORIOGONADOTROPIN AND THE ACTIVATION OF STEROIDOGENESIS IN LEYDIG TUMOR CELLS*

M. Ascoli, 1981 .

Lipid composition and gonadotropin-mediated lipid metabolism of the M5480 murine Leydig cell tumor.

D. Albert, M. Ascoli, D. Puett, 1980, Journal of lipid research.

Follitropin (FSH) and a phorbol ester stimulate the phosphorylation of the FSH receptor in intact cells.

M. Ascoli, J. Sánchez-Yagüe, J. Quintana, 1994, The Journal of biological chemistry.

A constitutively active mutant of the human lutropin receptor (hLHR-L457R) escapes lysosomal targeting and degradation.

C. Galet, M. Ascoli, 2006, Molecular endocrinology.

The postendocytotic trafficking of the human lutropin receptor is mediated by a transferable motif consisting of the C-terminal cysteine and an upstream leucine.

C. Galet, M. Ascoli, T. Hirakawa, 2004, Molecular endocrinology.

The postendocytotic trafficking of the hLHR is mediated by a transferable motif consisting of the C-terminal cysteine and an upstream leucine*

C. Galet, M. Ascoli, L. A. Carver, 2003 .

Characterization of an antiserum to the rat luteal luteinizing hormone/chorionic gonadotropin receptor.

N. Rosemblit, M. Ascoli, D. Segaloff, 1988, Endocrinology.

The ERK1/2 pathway regulates testosterone synthesis by coordinately regulating the expression of steroidogenic genes in Leydig cells

M. Ascoli, Soichi Yamashita, M. E. Matzkin, 2013, Molecular and Cellular Endocrinology.

Attenuation of cAMP-mediated responses in MA-10 Leydig tumor cells by genetic manipulation of a cAMP-phosphodiesterase.

M. Conti, J. Swinnen, M. Ascoli, 1991, The Journal of biological chemistry.

Immortalized Leydig Cell Lines as Models for Studying Leydig Cell Physiology

M. Ascoli, 2007 .

The post-endocytotic fate of the gonadotropin receptors is an important determinant of the desensitization of gonadotropin responses.

R. S. Bhaskaran, M. Ascoli, 2005, Journal of molecular endocrinology.

Human chorionic gonadotropin (CG)- and phorbol ester-stimulated phosphorylation of the luteinizing hormone/CG receptor maps to serines 635, 639, 649, and 652 in the C-terminal cytoplasmic tail.

M. Ascoli, R. W. Hipkin, Z. Wang, 1995, Molecular endocrinology.

Studies with insulin and insulin-like growth factor-I show that the increased labeling of phosphatidylinositol-3,4-bisphosphate is not sufficient to elicit the diverse actions of epidermal growth factor on MA-10 Leydig tumor cells.

O. Pignataro, M. Ascoli, 1990, Molecular endocrinology.

Regulation of the Differentiated Functions of Leydig Tumor Cells by Epidermal Growth Factor a

M. Ascoli, D. Segaloff, MARIO ASCOLI, 1989, Annals of the New York Academy of Sciences.

Arrestin-3 is essential for the activation of Fyn by the luteinizing hormone receptor (LHR) in MA-10 cells.

C. Galet, M. Ascoli, 2008, Cellular signalling.

A delayed, gonadotropin-dependent and growth-factor mediated activation of the ERK1/2 cascade negatively regulates aromatase expression in granulosa cells

M. Ascoli, N. Andric, Nebojsa Andric, 2008 .

The gonadotrophin receptors: insights from the cloning of their cDNAs.

M. Ascoli, D. Segaloff, 1992, Oxford reviews of reproductive biology.

Activation of the lutropin/choriogonadotropin receptor inhibits apoptosis of immature Leydig cells in primary culture.

K. Shiraishi, M. Ascoli, Ping Tai, 2009, Endocrinology.

Agonist-induced phosphorylation of the luteinizing hormone/chorionic gonadotropin receptor expressed in a stably transfected cell line.

M. Ascoli, J. Sánchez-Yagüe, R. W. Hipkin, 1993, Molecular endocrinology.

Identification and characterization of a luteinizing hormone/chorionic gonadotropin (LH/CG) receptor precursor in a human kidney cell line stably transfected with the rat luteal LH/CG receptor complementary DNA.

M. Ascoli, J. Sánchez-Yagüe, R. W. Hipkin, 1992, Molecular endocrinology.

Thyroid-Stimulating Hormone/Luteinizing Hormone/Follicle-Stimulating Hormone Receptors

M. Ascoli, D. Mizrachi, D. Segaloff, 2004 .

Inhibition of gonadotropin-responsive adenylate cyclase in MA-10 Leydig tumor cells by epidermal growth factor.

M. Ascoli, M. Pereira, D. Segaloff, 1988, The Journal of biological chemistry.

GIPC Binds to the Human Lutropin Receptor (hLHR) through an Unusual PDZ Domain Binding Motif, and It Regulates the Sorting of the Internalized Human Choriogonadotropin and the Density of Cell Surface hLHR*

C. Galet, M. Ascoli, M. Kishi, 2003, Journal of Biological Chemistry.

Functional consequences of the phosphorylation of the gonadotropin receptors.

M. Ascoli, 1996, Biochemical pharmacology.

The use of genetic manipulation of MA-10 Leydig tumor cells to demonstrate the role of mitochondrial proteins in the acute regulation of steroidogenesis.

D. Stocco, M. Ascoli, 1993, Endocrinology.

The lutropin/choriogonadotropin receptor, a 2002 perspective.

M. Ascoli, F. Fanelli, D. Segaloff, 2002, Endocrine reviews.

Degradation of the subunits of receptor-bound human choriogonadotropin by Leydig tumor cells.

M. Ascoli, 1980, Biochimica et biophysica acta.

Isolation and recombination of ovine lutropin subunits with complete recovery of biological activity.

W. Liu, M. Ascoli, D. N. Ward, 1977, The Journal of biological chemistry.

Ovine lutropin subunit isolation. Comparison of salt precipitation and countercurrent distribution procedures.

W. Liu, M. Ascoli, D. N. Ward, 1977, The Journal of biological chemistry.

Postendocytotic trafficking of the follicle-stimulating hormone (FSH)-FSH receptor complex.

C. Galet, H. Krishnamurthy, R. S. Bhaskaran, 2003, Molecular endocrinology.

Multiple luteinizing hormone/chorionic gonadotropin receptor messenger ribonucleic acid transcripts.

M. Ascoli, D. Segaloff, H. Wang, 1991, Endocrinology.

Structure of the lutropin/choriogonadotropin receptor.

R. Sprengel, M. Ascoli, K. Nikolics, 1990, Recent progress in hormone research.

On the structure of the luteinizing hormone/chorionic gonadotropin receptor.

M. Ascoli, D. Segaloff, 1989, Endocrine reviews.

RECEPTOR‐MEDIATED UPTAKE AND DEGRADATION OF HUMAN CHORIONIC GONADOTROPIN: FATE OF THE HORMONE SUBUNITS *

M. Ascoli, 1982, Annals of the New York Academy of Sciences.

Characterization of the desensitized state of Leydig tumor cells.

M. Ascoli, D. Puett, D. Segaloff, 1981, Biochimica et biophysica acta.

Inhibition of the degradation of receptor-bound human choriogonadotropin by leupeptin.

M. Ascoli, 1979, Biochimica et biophysica acta.

Demonstration of a direct effect of inhibitors of the degradation of receptor-bound human choriogonadotropin on the steroidogenic pathway.

M. Ascoli, 1978, The Journal of biological chemistry.

Inhibition of the degradation of receptor-bound human choriogonadotropin by lysosomotropic agents, protease inhibitors, and metabolic inhibitors.

M. Ascoli, D. Puett, 1978, The Journal of biological chemistry.

Conformational and metabolic aspects of gonadotropins.

M. Ascoli, D. Puett, L. A. Holladay, 1974, Current topics in molecular endocrinology.

Chapter 2 – The Gonadotropin Hormones and Their Receptors∗

M. Ascoli, P. Narayan, 2014 .

Characterization of steroid production in cultured human choriocarcinoma cells.

M. Ascoli, K. Speeg, D. Rabin, 1981, The Journal of clinical endocrinology and metabolism.

Luteinizing Hormone Action and Receptors

M. Ascoli, 2019 .

A constitutively active somatic mutation of the human lutropin receptor found in Leydig cell tumors activates the same families of G proteins as germ line mutations associated with Leydig cell hyperplasia.

M. Ascoli, T. Hirakawa, 2003, Endocrinology.

Biotransformations of pituitary luteinizing hormone in serum and urine. I. Association with serum components.

M. Ascoli, D. Puett, 1976, Endocrinology.

Biotransformations of pituitary luteinizing hormone in serum and urine. II. Evidence for reduced potency following urinary excretion.

M. Ascoli, D. Puett, 1976, Endocrinology.

The lutropin/choriogonadotropin receptor ... 4 years later.

M. Ascoli, D. Segaloff, 1993, Endocrine reviews.

Lutropin/choriogonadotropin stimulate the proliferation of primary cultures of rat Leydig cells through a pathway that involves activation of the extracellularly regulated kinase 1/2 cascade.

K. Shiraishi, M. Ascoli, 2007, Endocrinology.

MA-10 cells transfected with the human lutropin/choriogonadotropin receptor (hLHR): a novel experimental paradigm to study the functional properties of the hLHR.

C. Galet, M. Ascoli, T. Hirakawa, 2002, Endocrinology.

The dynamics of the steroidogenic response of perifused Leydig tumor cells to human chorionic gonadotropin, ovine luteinizing hormone, cholera toxin, and adenosine 3',5'-cyclic monophosphate.

M. Ascoli, D. Puett, D. Segaloff, 1981, Endocrinology.

Desensitization to gonadotropins in cultured Leydig tumor cells involves loss of gonadotropin receptors and decreased capacity for steroidogenesis.

M. Ascoli, D. Freeman, 1981, Proceedings of the National Academy of Sciences of the United States of America.

Renal uptake of lutropin. Studies based on electron microscopic autoradiography and nephrectomy

M. Ascoli, D. Puett, R. Liddle, 1977, Molecular and Cellular Biochemistry.

Tritium labeling of luteinizing hormone by reductive methylation.

M. Ascoli, D. Puett, 1974, Biochimica et biophysica acta.

Molecular basis of the regulation of the lutropin/choriogonadotropin receptor.

M. Ascoli, 1997, Biochemical Society transactions.

Epidermal growth factor and phorbol esters reduce the levels of the cognate mRNA for the LH/CG receptor.

M. Ascoli, D. Segaloff, H. Wang, 1991, Endocrinology.

Mutations That Induce Constitutive Activation and Mutations That Impair Signal Transduction Modulate the Basal and/or Agonist-stimulated Internalization of the Lutropin/Choriogonadotropin Receptor*

Xuebo Liu, M. Ascoli, A. Abell, 1998, The Journal of Biological Chemistry.

The lutropin/choriogonadotropin receptor-induced phosphorylation of the extracellular signal-regulated kinases in leydig cells is mediated by a protein kinase a-dependent activation of ras.

M. Ascoli, T. Hirakawa, 2003, Molecular endocrinology.

Identification of a transferable two-amino-acid motif (GT) present in the C-terminal tail of the human lutropin receptor that redirects internalized G protein-coupled receptors from a degradation to a recycling pathway.

C. Galet, N. Weigel, M. Ascoli, 2003, Molecular endocrinology.

Na+ modulates the affinity of the lutropin/choriogonadotropin receptor.

M. Ascoli, M Ascoli, K Buettner, 1984, The Journal of biological chemistry.

Potential Leydig cell mitogenic signals generated by the wild-type and constitutively active mutants of the lutropin/choriogonadotropin receptor (LHR)

M. Ascoli, 2007, Molecular and Cellular Endocrinology.

Lutropin/choriogonadotropin (LH/CG) stimulate the proliferation of primary cultures of rat Leydig cells through a pathway that involves activation of the ERK1/2 cascade

K. Shiraishi, M. Ascoli, 2007 .

Regulation of the LH/CG Receptor by Gonadotropins

J. Richards, M. Ascoli, D. Segaloff, 1992 .

Sequence variants in oxytocin pathway genes and preterm birth: a candidate gene association study

L. Muglia, M. Marazita, B. Feenstra, 2013, BMC Medical Genetics.

The 5'-flanking region of the rat luteinizing hormone/chorionic gonadotropin receptor gene confers Leydig cell expression and negative regulation of gene transcription by 3',5'-cyclic adenosine monophosphate.

M. Ascoli, S. Nelson, D. Segaloff, 1992, Molecular endocrinology.

Transactivation of the epidermal growth factor receptor is involved in the lutropin receptor-mediated down-regulation of ovarian aromatase expression in vivo.

M. Ascoli, N. Andric, Mika R. Thomas, 2010, Molecular endocrinology.

The luteinizing hormone receptor-activated extracellularly regulated kinase-1/2 cascade stimulates epiregulin release from granulosa cells.

M. Ascoli, N. Andric, Nebojsa Andric, 2008, Endocrinology.

A delayed gonadotropin-dependent and growth factor-mediated activation of the extracellular signal-regulated kinase 1/2 cascade negatively regulates aromatase expression in granulosa cells.

M. Ascoli, N. Andric, Nebojsa Andric, 2006, Molecular endocrinology.

The differential binding affinities of the luteinizing hormone (LH)/choriogonadotropin receptor for LH and choriogonadotropin are dictated by different extracellular domain residues.

C. Galet, M. Ascoli, 2005, Molecular endocrinology.

Biochemical properties of the agonist-induced desensitization of the follicle-stimulating hormone and luteinizing hormone/chorionic gonadotropin-responsive adenylyl cyclase in cells expressing the recombinant gonadotropin receptors.

M. Ascoli, J. Sánchez-Yagüe, R. Hipkin, 1993, Endocrinology.

Epidermal growth factor activates steroid biosynthesis in cultured Leydig tumor cells without affecting the levels of cAMP and potentiates the activation of steroid biosynthesis by choriogonadotropin and cAMP.

M. Ascoli, D. Segaloff, J. Euffa, 1987, The Journal of biological chemistry.

Identification of a Leydig tumor cell protein that is phosphorylated in response to stimulation with choriogonadotropin or epidermal growth factor.

M. Ascoli, S. Hoelscher, 1993, Endocrinology.

Lutropin/choriogonadotropin down-regulates its receptor by both receptor-mediated endocytosis and a cAMP-dependent reduction in receptor mRNA.

M. Ascoli, D. Segaloff, H. Wang, 1991, The Journal of biological chemistry.

Steroidogenesis in HCG-responsive Leydig cell tumor variants.

M. Ascoli, A. Lacroix, D. Puett, 1979, Journal of steroid biochemistry.

Inhibition of Steroidogenesis in Cultured Leydig Tumor Cells by 22-Amino-23,24-Bisnor-5-Cholen-3β-Ol and (20R)20-Phenyl-5-Pregnene-3β,20-Diol

M. Ascoli, L. Vickery, J. Sheets, 1983 .

Gq/11-Dependent Changes in the Murine Ovarian Transcriptome at the End of Gestation

M. Ascoli, Courtney Waite, R. Mejia, 2016, Biology of reproduction.

Running Title: Ovarian Gq/11 and parturition transcriptome Summary sentence: We have identified and characterized the expression of ovarian genes that increase or decrease at the end of gestation in a Gq/11-dependent fashion. Key terms: Parturition, Gq/11, transcriptome

M. Ascoli, Courtney Waite, R. Mejia, 2016 .

Reduced gonadotropin responses in a novel clonal strain of Leydig tumor cells established by transfection of MA-10 cells with a mutant gene of the type I regulatory subunit of the cAMP-dependent protein kinase.

M. Ascoli, H. Wang, 1990, Molecular endocrinology.

Ovulation involves the luteinizing hormone-dependent activation of G(q/11) in granulosa cells.

M. Ascoli, N. Andric, J. Gossen, 2013, Molecular endocrinology.

Mutations of the lutropin/choriogonadotropin receptor that do not activate the phosphoinositide cascade allow hCG to induce aromatase expression in immature rat granulosa cells

M. Ascoli, N. Andric, Nebojsa Andric, 2008, Molecular and Cellular Endocrinology.

The differential effects of the gonadotropin receptors on aromatase expression in primary cultures of immature rat granulosa cells are highly dependent on the density of receptors expressed and the activation of the inositol phosphate cascade.

M. Ascoli, F. X. Donadeu, 2005, Endocrinology.

Frontiers in Reproduction (FIR): An Assessment of Success

A. Fazleabas, M. Ascoli, Dorianne Mebane, 2016, Biology of reproduction.

The agonist-induced phosphorylation of the rat follitropin receptor maps to the first and third intracellular loops.

M. Ascoli, K. Nakamura, R. Hipkin, 1998, Molecular endocrinology.

Transfected cells express mostly the intracellular precursor of the lutropin/choriogonadotropin receptor but this precursor binds choriogonadotropin with high affinity.

M. Ascoli, S. Ryan, J. Fabritz, 1998, Biochemistry.

Mutation of a highly conserved acidic residue present in the second intracellular loop of G-protein-coupled receptors does not impair hormone binding or signal transduction of the luteinizing hormone/chorionic gonadotropin receptor.

M. Ascoli, H. Wang, Z. Wang, 1993, Molecular endocrinology.

Gonadotropin binding and stimulation of steroidogenesis in Leydig tumor cells.

M. Ascoli, D. Puett, M Ascoli, 1978, Proceedings of the National Academy of Sciences of the United States of America.

Reactive oxygen species (ROS) play a critical role in the cAMP-induced activation of Ras and the phosphorylation of ERK1/2 in Leydig cells.

M. Ascoli, Ping Tai, 2011, Molecular endocrinology.

Induction of renin activity by gonadotropic hormones in cultured Leydig tumor cells.

T. Inagami, M. Ascoli, K. Pandey, 1985, Endocrinology.

Truncation of the C-terminal Tail of the Follitropin Receptor Does Not Impair the Agonist- or Phorbol Ester-induced Receptor Phosphorylation and Uncoupling (*)

Xuebo Liu, M. Ascoli, R. Hipkin, 1995, The Journal of Biological Chemistry.

Activation of the lutropin/choriogonadotropin receptor in MA-10 cells stimulates tyrosine kinase cascades that activate ras and the extracellular signal regulated kinases (ERK1/2).

K. Shiraishi, M. Ascoli, 2006, Endocrinology.

The inositol phosphate/diacylglycerol pathway in MA-10 Leydig tumor cells. Activation by arginine vasopressin and lack of effect of epidermal growth factor and human choriogonadotropin.

O. Pignataro, M. Ascoli, D. Segaloff, 1989, The Journal of biological chemistry.

Identification of a Short Linear Sequence Present in the C-terminal Tail of the Rat Follitropin Receptor That Modulates Arrestin-3 Binding in a Phosphorylation-independent Fashion*

C. Galet, H. Krishnamurthy, R. S. Bhaskaran, 2002, The Journal of Biological Chemistry.

The regulation of the binding affinity of the luteinizing hormone/choriogonadotropin receptor by sodium ions is mediated by a highly conserved aspartate located in the second transmembrane domain of G protein-coupled receptors.

M. Ascoli, J. Quintana, H. Wang, 1993, Molecular endocrinology.

A co-culture system reveals the involvement of intercellular pathways as mediators of the lutropin receptor (LHR)-stimulated ERK1/2 phosphorylation in Leydig cells.

K. Shiraishi, M. Ascoli, 2008, Experimental cell research.

An improved method for the solubilization of stable gonadotropin receptors.

M. Ascoli, 1983, Endocrinology.

Signaling and Phosphorylation-impaired Mutants of the Rat Follitropin Receptor Reveal an Activation- and Phosphorylation-independent but Arrestin-dependent Pathway for Internalization*

J. Benovic, M. Ascoli, J. Krupnick, 1998, The Journal of Biological Chemistry.

Removal of the surface-bound human choriogonadotropin results in the cessation of hormonal responses in cultured Leydig tumor cells.

M. Ascoli, D. Segaloff, 1981, The Journal of biological chemistry.

Lysosomal accumulation of the hormone-receptor complex during receptor- mediated endocytosis of human choriogonadotropin

Lina Jing, M. Ascoli, Dena Ke, 1984, The Journal of cell biology.

Truncation of the cytoplasmic tail of the lutropin/choriogonadotropin receptor prevents agonist-induced uncoupling.

M. Ascoli, J. Sánchez-Yagüe, D. Segaloff, 1992, The Journal of biological chemistry.

Two mutations of the lutropin/choriogonadotropin receptor that impair signal transduction also interfere with receptor-mediated endocytosis.

M. Ascoli, K. Dhanwada, U. Vijapurkar, 1996, Molecular endocrinology.

Receptor-Mediated Endocytosis

M. Ascoli, K. Dhanwada, U. Vijapurkar, 1996 .

Progressive cytoplasmic tail truncations of the lutropin-choriogonadotropin receptor prevent agonist- or phorbol ester-induced phosphorylation, impair agonist- or phorbol ester-induced desensitization, and enhance agonist-induced receptor down-regulation.

M. Ascoli, Z. Wang, R. Hipkin, 1996, Molecular endocrinology.

Epidermal growth factor, a phorbol ester, and 3',5'-cyclic adenosine monophosphate decrease the transcription of the luteinizing hormone/chorionic gonadotropin receptor gene in MA-10 Leydig tumor cells.

M. Ascoli, S. Nelson, 1992, Endocrinology.

The lutropin/choriogonadotropin receptor is palmitoylated at intracellular cysteine residues.

M. Ascoli, H. Wang, Hongyu Zhu, 1995, Molecular endocrinology.

Learning new tricks from an old dog: the processing of the intracellular precursor of the luteinizing hormone receptor (LHR) into the mature cell-surface LHR is a regulated process.

M. Ascoli, 2005, Endocrinology.

A polyclonal antibody to a synthetic peptide derived from the rat follicle-stimulating hormone receptor reveals the recombinant receptor as a 74-kilodalton protein.

M. Ascoli, J. Quintana, R. Hipkin, 1993, Endocrinology.

Desensitization of steroidogenesis in cultured Leydig tumor cells: role of cholesterol.

M. Ascoli, D. Freeman, 1982, Proceedings of the National Academy of Sciences of the United States of America.

Epidermal growth factor increases the labeling of phosphatidylinositol 3,4-bisphosphate in MA-10 Leydig tumor cells.

O. Pignataro, M. Ascoli, 1990, Journal of Biological Chemistry.