F. Roelfsema

发表

Impact of Meal Timing and Frequency on the Twenty-Four-Hour Leptin Rhythm

H. Pijl, A. Fogteloo, F. Roelfsema, 2004, Hormone Research in Paediatrics.

UvA-DARE ( Digital Academic Repository ) Network identification of hormonal regulation

A. Smilde, H. Hoefsloot, M. Hendriks, 2014 .

Clinical and biochemical characteristics of a male patient with a novel homozygous STAT5b mutation.

R. Janssen, J. Romijn, S. White, 2006, The Journal of clinical endocrinology and metabolism.

Diagnosis, treatment and clinical perspectives of

F. Roelfsema, 2015 .

Circadian and pulsatile thyrotropin release in treated acromegalics

F. Roelfsema, M. Frölich, H. Boer, 1989, Journal of endocrinological investigation.

PROLACTIN AND LUTEINIZING HORMONE PROFILES OF CURED ACROMEGALIC SUBJECTS

F. Roelfsema, M. Frölich, H. Boer, 1989, Clinical endocrinology.

UvA-DARE ( Digital Academic Repository ) Dynamic metabolomic data analysis : a tutorial

A. Smilde, H. Hoefsloot, H. Pijl, 2010 .

Effects of olanzapine and haloperidol on the metabolic status of healthy men.

H. Pijl, J. Romijn, F. Roelfsema, 2010, The Journal of clinical endocrinology and metabolism.

GH replacement therapy in elderly GH-deficient patients: a systematic review.

J. Romijn, F. Roelfsema, J. Smit, 2011, European journal of endocrinology.

Additional beneficial effects of alendronate in growth hormone (GH)-deficient adults with osteoporosis receiving long-term recombinant human GH replacement therapy: a randomized controlled trial.

F. Roelfsema, N. Biermasz, N. Hamdy, 2001, The Journal of clinical endocrinology and metabolism.

The absorption profile and availability of a physiological subcutaneously administered dose of recombinant human growth hormone (GH) in adults with GH deficiency.

F. Roelfsema, M. Frölich, Y. J. Janssen, 1999, British journal of clinical pharmacology.

Skeletal effects of two years of treatment with low physiological doses of recombinant human growth hormone (GH) in patients with adult-onset GH deficiency.

F. Roelfsema, M. Frölich, N. Hamdy, 1998, The Journal of clinical endocrinology and metabolism.

A low starting dose of genotropin in growth hormone-deficient adults.

F. Roelfsema, M. Frölich, Y. J. Janssen, 1997, The Journal of clinical endocrinology and metabolism.

Growth hormone and ghrelin secretion in Huntington’s disease

H. Pijl, R. Roos, N. Aziz, 2010 .

Growth hormone secretion and immunological function of a male patient with a homozygous STAT 5 b mutation

R. Janssen, J. Romijn, J. Wit, 2007 .

Growth hormone secretion and immunological function of a male patient with a homozygous STAT5b mutation.

R. Janssen, J. Romijn, H. V. van Duyvenvoorde, 2007, European journal of endocrinology.

Profound amplification of secretory‐burst mass and anomalous regularity of ACTH secretory process in patients with Nelson's syndrome compared with Cushing's disease

J. Romijn, J. Veldhuis, F. Roelfsema, 2004, Clinical endocrinology.

Increase in daily LH secretion in response to short-term calorie restriction in obese women with PCOS.

H. Pijl, J. Veldhuis, F. Roelfsema, 2002, American journal of physiology. Endocrinology and metabolism.

Pulsatile, nyctohemeral and entropic characteristics of GH secretion in adult GH‐deficient patients: selectively decreased pulsatile release and increased secretory disorderliness with preservation of diurnal timing and gender distinctions

J. Veldhuis, F. Roelfsema, N. Biermasz, 2002, Clinical endocrinology.

Growth hormone (GH) secretion in patients with an inactivating defect of the GH-releasing hormone (GHRH) receptor is pulsatile: evidence for a role for non-GHRH inputs into the generation of GH pulses.

J. Wit, J. Veldhuis, F. Roelfsema, 2001, The Journal of clinical endocrinology and metabolism.

Pituitary apoplexy in acromegaly, a long-term follow-up study in two patients

Steven M. Pincus, J. Veldhuis, F. Roelfsema, 1998, Journal of endocrinological investigation.

Combined amplification of the pulsatile and basal modes of adrenocorticotropin and cortisol secretion in patients with Cushing's disease: evidence for decreased responsiveness of the adrenal glands.

J. Veldhuis, F. Roelfsema, M. Frölich, 1995, The Journal of clinical endocrinology and metabolism.

Endogenous ACTH concentration-dependent drive of pulsatile cortisol secretion in the human.

Ferdinand Roelfsema, D. M. Keenan, Johannes D Veldhuis, 2004, American journal of physiology. Endocrinology and metabolism.

Response to Letter to the Editor from Richard Dorin: Dynamic pituitary-adrenal interactions in the critically ill after cardiac surgery.

D. Keenan, G. Angelini, S. Lightman, 2020, The Journal of clinical endocrinology and metabolism.

Impact of Adiposity and Fat Distribution on the Dynamics of Adrenocorticotropin and Cortisol Rhythms

J. Veldhuis, F. Roelfsema, Alberto M. Pereira, 2014, Current Obesity Reports.

Diminished adrenal sensitivity and ACTH efficacy in obese premenopausal women.

D. M. Keenan, D. Keenan, H. Pijl, 2012, European journal of endocrinology.

Physiological control of pituitary hormone secretory-burst mass, frequency, and waveform: a statistical formulation and analysis.

D. M. Keenan, D. Keenan, J. Veldhuis, 2003, American journal of physiology. Regulatory, integrative and comparative physiology.

Familial longevity is associated with lower baseline bone turnover but not differences in bone turnover in response to rhTSH

H. Pijl, R. Westendorp, D. van Heemst, 2021, Aging.

Circulating Thyroid Hormone Profile in Response to a Triiodothyronine Challenge in Familial Longevity

H. Pijl, R. Westendorp, D. van Heemst, 2020, Journal of the Endocrine Society.

Acromegaly caused by growth hormone-relating hormone in a patient with multiple endocrine neoplasia type I.

J. Kievit, F. Roelfsema, C. V. D. van de Velde, 1996, Japanese journal of clinical oncology.

Postoperative radiotherapy in acromegaly is effective in reducing GH concentration to safe levels

F. Roelfsema, N. Biermasz, H. Dulken, 2000, Clinical endocrinology.

Delayed onset of the diurnal melatonin rise in patients with Huntington’s disease

H. Pijl, R. Roos, N. Aziz, 2009, Journal of Neurology.

Pharmacologic Therapies for Acromegaly

J. Romijn, F. Roelfsema, Alberto M. Pereira, 2005, Treatments in endocrinology.

GLUCOSE TOLERANCE AND PLASMA IMMUNOREACTIVE INSULIN LEVELS IN ACROMEGALICS BEFORE AND AFTER SELECTIVE TRANSSPHENOIDAL SURGERY

F. Roelfsema, M. Frölich, M. Frölich, 1985, Clinical endocrinology.

Growth hormone secretion is diminished and tightly controlled in humans enriched for familial longevity

H. Pijl, P. Slagboom, R. Westendorp, 2016, Experimental Gerontology.

Familial Longevity is Associated with an Attenuated Thyroidal Response to Recombinant Human Thyroid Stimulating Hormone

H. Pijl, R. Westendorp, D. van Heemst, 2020, The Journal of clinical endocrinology and metabolism.

Long-term effects of recombinant human GH replacement in adults with GH deficiency: a systematic review.

F. Roelfsema, Alberto M. Pereira, N. Biermasz, 2013, European journal of endocrinology.

Long‐term skeletal effects of recombinant human growth hormone (rhGH) alone and rhGH combined with alendronate in GH‐deficient adults: a seven‐year follow‐up study

J. Romijn, F. Roelfsema, N. Biermasz, 2004, Clinical endocrinology.

Diabetes insipidus in metastatic cancer: two case reports with review of the literature.

H. Keizer, T. Huizinga, F. Roelfsema, 2000, Annals of oncology : official journal of the European Society for Medical Oncology.

High prevalence of long‐term cardiovascular, neurological and psychosocial morbidity after treatment for craniopharyngioma

J. Romijn, F. Roelfsema, E. Corssmit, 2005, Clinical endocrinology.

Increased aortic root diameters in patients with acromegaly.

Jeroen J. Bax, E. Holman, J. Romijn, 2008, European journal of endocrinology.

Lanreotide Autogel® in the Treatment of Acromegaly:

J. Romijn, F. Roelfsema, N. Biermasz, 2009 .

Therapeutic options in the management of acromegaly: focus on lanreotide Autogel®

J. Romijn, F. Roelfsema, N. Biermasz, 2008, Biologics : targets & therapy.

Role of radiotherapy in the management of acromegaly

J. Romijn, F. Roelfsema, N. Biermasz, 2006, Expert review of endocrinology & metabolism.

Treatment of Acromegaly: Are We Satisfied With the Current Outcome?

F. Roelfsema, 2014, EBioMedicine.

Acromegaly is associated with an increased prevalence of colonic diverticula: a case-control study.

D. Hommes, J. Romijn, F. Roelfsema, 2010, The Journal of clinical endocrinology and metabolism.

Uncontrolled acromegaly is associated with progressive mitral valvular regurgitation.

Jeroen J. Bax, E. Holman, E. E. van der Wall, 2006, Growth hormone & IGF research : official journal of the Growth Hormone Research Society and the International IGF Research Society.

11 Intravenous octreotide test predicts the long term outcom e of treatm ent w ith octreotide-long-acting repeatable in active acrom egaly

J. Romijn, F. Roelfsema, J. Smit, 2006 .

Intravenous octreotide test predicts the long term outcome of treatment with octreotide-long-acting repeatable in active acromegaly.

J. Romijn, F. Roelfsema, J. Smit, 2005, Growth hormone & IGF research : official journal of the Growth Hormone Research Society and the International IGF Research Society.

Current pharmacotherapy for acromegaly: a review

J. Romijn, F. Roelfsema, N. Biermasz, 2005, Expert opinion on pharmacotherapy.

Primary pheochromocytoma extending into the right atrium: report of a case and review of the literature.

R. Tollenaar, C. V. D. van de Velde, F. Roelfsema, 2001, European journal of surgical oncology : the journal of the European Society of Surgical Oncology and the British Association of Surgical Oncology.

Regulatory aspects of the human hypothalamus-pituitary-thyroid axis.

A. Kalsbeek, E. Fliers, F. Roelfsema, 2017, Best practice & research. Clinical endocrinology & metabolism.

Thyrotropin secretion profiles are not different in men and women.

E. Fliers, J. Romijn, J. Veldhuis, 2009, The Journal of clinical endocrinology and metabolism.

Modulating Effects of Progesterone on Spontaneous Nocturnal and Ghrelin-Induced GH Secretion in Postmenopausal Women.

J. Veldhuis, F. Roelfsema, C. Bowers, 2019, The Journal of clinical endocrinology and metabolism.

Dynamic Interactions between LH and Testosterone in Healthy Community-Dwelling Men: Impact of Age and Body Composition.

P. Takahashi, J. Veldhuis, F. Roelfsema, 2019, The Journal of clinical endocrinology and metabolism.

Enhanced Coupling Within Gonadotropic and Adrenocorticotropic Axes by Moderate Exercise in Healthy Men

P. Takahashi, M. Joyner, J. Veldhuis, 2017, The Journal of clinical endocrinology and metabolism.

Prolactin Secretion in Healthy Adults Is Determined by Gender, Age and Body Mass Index

D. M. Keenan, H. Pijl, J. Veldhuis, 2012, PloS one.

Altered multihormone synchrony in obese patients with polycystic ovary syndrome.

H. Pijl, J. Veldhuis, F. Roelfsema, 2011, Metabolism: clinical and experimental.

Pituitary-hormone secretion by thyrotropinomas

D. M. Keenan, J. Romijn, J. Veldhuis, 2008, Pituitary.

Growth hormone secretion in primary adrenal Cushing's syndrome is disorderly and inversely correlated with body mass index.

H. Pijl, J. Romijn, J. Veldhuis, 2005, American journal of physiology. Endocrinology and metabolism.

Optimizing Blood Sampling Protocols in Patients With Acromegaly for the Estimation of Growth Hormone Secretion.

J. Veldhuis, F. Roelfsema, N. Biermasz, 2016, The Journal of clinical endocrinology and metabolism.

Reduction of plasma leptin levels and loss of its circadian rhythmicity in hypocretin (orexin)-deficient narcoleptic humans.

H. Pijl, S. Overeem, F. Roelfsema, 2002, The Journal of clinical endocrinology and metabolism.

Sex defines the age dependence of endogenous ACTH-cortisol dose responsiveness.

D. M. Keenan, B. Carroll, A. Iranmanesh, 2009, American journal of physiology. Regulatory, integrative and comparative physiology.

Efficacy of needle-free administration of recombinant human growth hormone in adults with growth hormone deficiency.

J. Romijn, F. Roelfsema, H. Koppeschaar, 2006, British journal of clinical pharmacology.

GLUCAGON‐STIMULATED PLASMA C‐PEPTIDE AND INSULIN LEVELS IN ACTIVE AND NON‐ACTIVE ACROMEGALICS

F. Roelfsema, A. Kruseman, M. Frölich, 1985, Clinical endocrinology.

Long-term maintenance of the anabolic effects of GH on the skeleton in successfully treated patients with acromegaly.

J. Romijn, F. Roelfsema, N. Biermasz, 2005, European journal of endocrinology.

Calcium and Phosphorus Metabolism, Parathyroid Hormone, Calcitonin and Bone Histology in Pseudohypoparathyroidism *

F. Roelfsema, J. Birkenhäger, W. Hackeng, 1973, European journal of clinical investigation.

The influence of partial food deprivation on the quantity and source of triiodothyronine in several tissues of athyreotic thyroxine-maintained rats.

F. Roelfsema, J. van Doorn, D. van der Heide, 1984, Endocrinology.

Hormone pulsatility discrimination via coarse and short time sampling.

Ferdinand Roelfsema, Steven M. Pincus, Johannes D Veldhuis, 1999, American journal of physiology. Endocrinology and metabolism.

J. Wit, J. Veldhuis, F. Roelfsema, 2001, The Journal of clinical endocrinology and metabolism.

Retention of estradiol negative feedback relationship to LH predicts ovulation in response to caloric restriction and weight loss in obese patients with polycystic ovary syndrome.

H. Pijl, J. Veldhuis, F. Roelfsema, 2004, American journal of physiology. Endocrinology and metabolism.

THE INFLUENCE OF OCTREOTIDE TREATMENT ON PULSATILE GROWTH HORMONE RELEASE IN ACROMEGALY

F. Roelfsema, H. Boer, M. Frölich, 1990, Clinical endocrinology.

Octreotide represses secretory-burst mass and nonpulsatile secretion but does not restore event frequency or orderly GH secretion in acromegaly.

J. Romijn, J. Veldhuis, F. Roelfsema, 2004, American journal of physiology. Endocrinology and metabolism.

Acromegaly caused by growth hormone-releasing hormone-producing tumors: long-term observational studies in three patients

J. Romijn, F. Roelfsema, J. Smit, 2007, Pituitary.

Pulsatile Cortisol Feedback on ACTH Secretion Is Mediated by the Glucocorticoid Receptor and Modulated by Gender.

J. Veldhuis, F. Roelfsema, P. Aoun, 2016, The Journal of clinical endocrinology and metabolism.

IGSF1 Deficiency Results in Human and Murine Somatotrope Neurosecretory Hyperfunction

J. Wit, P. L. Le Tissier, O. Koulouri, 2019, The Journal of clinical endocrinology and metabolism.

Dynamic pituitary-adrenal interactions in the critically ill after cardiac surgery.

D. M. Keenan, G. Angelini, S. Lightman, 2019, The Journal of clinical endocrinology and metabolism.

Feedback on LH in Testosterone-Clamped Men Depends on the Mode of Testosterone Administration and Body Composition

P. Takahashi, J. Veldhuis, F. Roelfsema, 2018, Journal of the Endocrine Society.

Aromatized Estrogens Amplify Nocturnal Growth Hormone Secretion in Testosterone-Replaced Older Hypogonadal Men

P. Takahashi, J. Veldhuis, F. Roelfsema, 2018, The Journal of clinical endocrinology and metabolism.

Tripartite control of dynamic ACTH-cortisol dose responsiveness by age, body mass index, and gender in 111 healthy adults.

D. M. Keenan, A. Iranmanesh, P. Takahashi, 2011, The Journal of clinical endocrinology and metabolism.

Gender, age, body mass index, and IGF-I individually and jointly determine distinct GH dynamics: analyses in one hundred healthy adults.

Steven M. Pincus, D. M. Keenan, J. Veldhuis, 2011, The Journal of clinical endocrinology and metabolism.

Cortisol production rate is similarly elevated in obese women with or without the polycystic ovary syndrome.

H. Pijl, F. Roelfsema, A. Pereira, 2010, The Journal of clinical endocrinology and metabolism.

Apparently complete restoration of normal daily adrenocorticotropin, cortisol, growth hormone, and prolactin secretory dynamics in adults with Cushing's disease after clinically successful transsphenoidal adenomectomy.

Steven M. Pincus, J. Veldhuis, F. Roelfsema, 2000, The Journal of clinical endocrinology and metabolism.

Mutations in IRS4 are associated with central hypothyroidism

R. Hennekam, E. Fliers, F. Roelfsema, 2018, Journal of Medical Genetics.

Diminished and irregular thyrotropin secretion with preserved diurnal rhythm in patients with active acromegaly.

D. M. Keenan, J. Romijn, J. Veldhuis, 2009, The Journal of clinical endocrinology and metabolism.

Bromocriptine reduces augmented thyrotropin secretion in obese premenopausal women.

H. Pijl, J. van Pelt, F. Roelfsema, 2009, The Journal of clinical endocrinology and metabolism.

Concentrations of thyroxine and 3,5,3'-triiodothyronine at 34 different sites in euthyroid rats as determined by an isotopic equilibrium technique.

F. Roelfsema, J. van Doorn, D. van der Heide, 1985, Endocrinology.

Resynchronization patterns for urinary rhythms in rats after light-dark shifts.

F. Roelfsema, D. van der Heide, D. Smeenk, 1985, The American journal of physiology.

The influence of bromocriptine and transsphenoidal surgery on urinary androgen metabolite excretion in acromegaly.

F. Roelfsema, A. Moolenaar, M. Frölich, 1984, Acta endocrinologica.

THE INFLUENCE OF BROMOCRIPTINE ON SERUM LEVELS OF GROWTH HORMONE AND OTHER PITUITARY HORMONES AND ITS METABOLIC EFFECTS IN ACTIVE ACROMEGALY

F. Roelfsema, H. Slooten, B. Goslings, 1979, Clinical endocrinology.

An amplitude-specific divergence in the pulsatile mode of growth hormone (GH) secretion underlies the gender difference in mean GH concentrations in men and premenopausal women.

J. Veldhuis, F. Roelfsema, G. van den Berg, 1996, The Journal of clinical endocrinology and metabolism.

Mortality in patients treated for Cushing's disease is increased, compared with patients treated for nonfunctioning pituitary macroadenoma.

O. Dekkers, J. Romijn, M. O. Aken, 2007, The Journal of clinical endocrinology and metabolism.

Persistent diastolic dysfunction despite successful long-term octreotide treatment in acromegaly.

Jeroen J. Bax, E. Holman, E. E. van der Wall, 2005, European journal of endocrinology.

Estradiol Does Not Influence Lipid Measures and Inflammatory Markers in Testosterone-Clamped Healthy Men

J. Veldhuis, F. Roelfsema, Rebecca Yang, 2018, Journal of the Endocrine Society.

Future perspectives of diagnosis and treatment of acromegaly

F. Roelfsema, N. Biermasz, 2013 .

Low incidence of adrenal insufficiency after transsphenoidal surgery in patients with acromegaly: a long-term follow-up study.

J. Romijn, F. Roelfsema, J. Smit, 2011, The Journal of clinical endocrinology and metabolism.

Cost–effectiveness of lanreotide Autogel® in treatment algorithms of acromegaly

J. Romijn, F. Roelfsema, N. Biermasz, 2009, Expert review of pharmacoeconomics & outcomes research.

Nanomedicines in the treatment of acromegaly: focus on pegvisomant

F. Roelfsema, N. Biermasz, A. Pereira, 2006, International journal of nanomedicine.

Treatment strategies for acromegaly

J. Romijn, F. Roelfsema, N. Biermasz, 2005, Expert opinion on emerging drugs.

Pituitary magnetic resonance imaging is not required in the postoperative follow-up of acromegalic patients with long-term biochemical cure after transsphenoidal surgery.

M. van Buchem, J. Romijn, F. Roelfsema, 2004, The Journal of clinical endocrinology and metabolism.

Sandostatin LAR in acromegaly: a 6‐week injection interval suppresses GH secretion as effectively as a 4‐week interval

J. Romijn, F. Roelfsema, N. Biermasz, 2003, Clinical endocrinology.

Proinflammatory Cytokine Infusion Attenuates LH's Feedforward on Testosterone Secretion: Modulation by Age.

P. Takahashi, J. Veldhuis, F. Roelfsema, 2016, The Journal of clinical endocrinology and metabolism.

Sources and quantity of 3,5,3'-triiodothyronine in several tissues of the rat.

F. Roelfsema, J. van Doorn, D. van der Heide, 1983, The Journal of clinical investigation.

Clinical and biochemical characteristics of a male patient with a novel homozygous STAT 5 b mutation 4

Marcel, R. Janssen, J. Romijn, 2007 .

The role of pegvisomant in the treatment of acromegaly

J. Romijn, F. Roelfsema, N. Biermasz, 2008 .

Disordered and increased adrenocorticotropin secretion with diminished adrenocorticotropin potency in obese in premenopausal women.

H. Pijl, F. Roelfsema, M. Frolich, 2009, The Journal of clinical endocrinology and metabolism.

Using dilution techniques and multifrequency bioelectrical impedance to assess both total body water and extracellular water at baseline and during recombinant human growth hormone (GH) treatment in GH-deficient adults.

P. Deurenberg, F. Roelfsema, Y. J. Janssen, 1997, The Journal of clinical endocrinology and metabolism.

Progressive improvement of impaired visual acuity during the first year after transsphenoidal surgery for non-functioning pituitary macroadenoma

O. Dekkers, J. Romijn, F. Roelfsema, 2007, Pituitary.

Increased prevalence of regurgitant valvular heart disease in acromegaly.

Jeroen J. Bax, E. E. van der Wall, J. Romijn, 2004, The Journal of clinical endocrinology and metabolism.

Determinants of survival in treated acromegaly in a single center: predictive value of serial insulin-like growth factor I measurements.

F. Dekker, J. Romijn, F. Roelfsema, 2004, The Journal of clinical endocrinology and metabolism.

LONG‐TERM RESULTS OF TRANSSPHENOIDAL PITUITARY MICROSURGERY IN 60 ACROMEGALIC PATIENTS

F. Roelfsema, H. Dulken, M. Frölich, 1985, Clinical endocrinology.

PLASMA GROWTH HORMONE HALF‐LIFE AFTER SELECTIVE REMOVAL OF ADENOMA IN ACROMEGALICS DETERMINES THE OUTCOME OF SURGERY

F. Roelfsema, P. Lowry, H. Dulken, 1988, Clinical endocrinology.

The interaction of GHRH with TRH in acromegaly: a controlled study.

F. Roelfsema, A. C. Nieuwenhuijzen Kruseman, M. Frölich, 1991, Acta endocrinologica.

Long-term predictive value of postsurgical cortisol concentrations for cure and risk of recurrence in Cushing's disease.

J. Romijn, F. Roelfsema, J. Smit, 2003, The Journal of clinical endocrinology and metabolism.

Coexpression of dopamine and somatostatin receptor subtypes in corticotroph adenomas.

J. Romijn, C. de Bruin, S. Lamberts, 2009, The Journal of clinical endocrinology and metabolism.

Plasma total ghrelin and leptin levels in human narcolepsy and matched healthy controls: basal concentrations and response to sodium oxybate.

H. Pijl, S. Overeem, N. Aziz, 2013, Journal of clinical sleep medicine : JCSM : official publication of the American Academy of Sleep Medicine.

Influence of Gender on Response to Growth Hormone Substitution Therapy in Adults with Growth Hormone Deficiency

F. Roelfsema, Y. J. Janssen, 1999 .

The effect of GHRH on TSH release in rats in vivo and in vitro

F. Roelfsema, R. Hoogma, A. Kruseman, 1995, Journal of endocrinological investigation.

Ghrelin Gene Deletion Alters Pulsatile Growth Hormone Secretion in Adult Female Mice

N. Lebrun, F. Roelfsema, C. Tomasetto, 2021, Frontiers in Endocrinology.

Interleukin-2 Transiently Inhibits Pulsatile Growth Hormone Secretion in Young but not Older Healthy Men.

J. Veldhuis, F. Roelfsema, Rebecca Yang, 2021, The Journal of clinical endocrinology and metabolism.

Effect of Growth Hormone Secretagogue Receptor Deletion on Growth, Pulsatile Growth Hormone Secretion, and Meal Pattern in Male and Female Mice

M. Bohlooly-y, J. Veldhuis, F. Roelfsema, 2021, Neuroendocrinology.

Interleukin-2 drives cortisol secretion in an age-, dose-, and body composition-dependent way

P. Takahashi, J. Veldhuis, F. Roelfsema, 2020, Endocrine connections.

Changes in basal and stimulated TSH and other parameters of thyroid function in acromegaly after transsphenoidal surgery.

F. Roelfsema, P. Geelhoed-Duijvestijn, J. Bussemaker, 1989, Acta endocrinologica.

Growth hormone secretion in recently operated acromegalic patients.

J. Veldhuis, F. Roelfsema, G. van den Berg, 1994, The Journal of clinical endocrinology and metabolism.

Pulsatile thyrotropin release and thyroid function in acromegalics before and during subcutaneous octreotide infusion.

F. Roelfsema, M. Frölich, 1991, The Journal of clinical endocrinology and metabolism.

Short-term treatment with olanzapine does not modulate gut hormone secretion: olanzapine disintegrating versus standard tablets.

J. Holst, J. Rehfeld, H. Pijl, 2010, European journal of endocrinology.

Short-term treatment with Olanzapine does not modulate gut hormone

J. Holst, J. Rehfeld, H. Pijl, 2009 .

7 Determinants of survival in treated acromegaly in a single center : predictive value of serial insulin-like grow th factor I measurements

F. Dekker, J. Romijn, F. Roelfsema, 2006 .

Ten-year follow-up results of transsphenoidal m icrosurgery in acrom egaly

F. Roelfsema, N. Biermasz, H. Dulken, 2006 .

High prevalence of arthropathy, according to the definitions of radiological and clinical osteoarthritis, in patients with long-term cure of acromegaly: a case-control study.

J. Romijn, F. Roelfsema, J. Smit, 2009, European journal of endocrinology.

Long-term follow-up results of postoperative radiotherapy in 36 patients with acromegaly.

F. Roelfsema, N. Biermasz, H. Dulken, 2000, The Journal of clinical endocrinology and metabolism.

Diminished Adrenal Sensitivity and Adrenocorticotropin

D. M. Keenan, H. Pijl, F. Roelfsema, 2012 .

An activating mutation in the kinase homology domain of the natriuretic peptide receptor-2 causes extremely tall stature without skeletal deformities.

A. Uitterlinden, A. Verkerk, C. Ruivenkamp, 2013, Journal of Clinical Endocrinology and Metabolism.

Effects of Toremifene, a Selective Estrogen Receptor Modulator, on Spontaneous and Stimulated GH Secretion, IGF-I, and IGF-Binding Proteins in Healthy Elderly Subjects

P. Takahashi, J. Veldhuis, F. Roelfsema, 2017, Journal of the Endocrine Society.

The natural course of non-functioning pituitary macroadenomas.

O. Dekkers, J. Romijn, F. Roelfsema, 2007, European journal of endocrinology.

THE EFFECT OF CALCITONIN ON GROWTH HORMONE SECRETION IN MAN

F. Roelfsema, A. Kruseman, J. Souverijn, 1988, Clinical endocrinology.

Thyrotropin secretion patterns in health and disease.

J. Veldhuis, F. Roelfsema, 2013, Endocrine reviews.

Attenuated pulse size, disorderly growth hormone and prolactin secretion with preserved nyctohemeral rhythm distinguish irradiated from surgically treated acromegaly patients

A. Iranmanesh, J. Romijn, J. Veldhuis, 2007, Clinical endocrinology.

Diagnosis, treatment and clinical perspectives of acromegaly

F. Roelfsema, G. van den Berg, 2015, Expert review of endocrinology & metabolism.

The influence of light on circadian rhythms

F. Roelfsema, 1987, Experientia.

The prevalence of the metabolic syndrome is increased in patients with GH deficiency, irrespective of long-term substitution with recombinant human GH.

E. Feskens, H. Pijl, J. Romijn, 2007, European journal of endocrinology.

Quality of life in patients after long-term biochemical cure of Cushing's disease.

J. Romijn, M. O. Aken, S. Lamberts, 2005, The Journal of clinical endocrinology and metabolism.

Olanzapine shifts the temporal relationship between the daily acrophase of serum prolactin and cortisol concentrations rhythm in healthy men

H. Pijl, F. Roelfsema, S. Vidarsdóttir, 2009, Psychoneuroendocrinology.

Phase difference between serum prolactin and cortisol rhythms is related to body mass index in humans.

H. Pijl, F. Roelfsema, 2012, The Journal of clinical endocrinology and metabolism.

Patterns of urinary calcium and phosphate excretion in restrained rats

F. Roelfsema, C. M. Vos, D. Smeenk, 1976, Calcified Tissue Research.

Comparing Methods for Measurement Error Detection in Serial 24-h Hormonal Data

Jungyeon Choi, Ferdinand Roelfsema, Olaf M Dekkers, 2019, Journal of biological rhythms.

Sodium oxybate increases prolactin secretion in narcolepsy patients and healthy controls.

H. Pijl, S. Overeem, N. Aziz, 2011, European journal of endocrinology.

Altered thyrotropic and lactotropic axes regulation in Huntington’s disease

H. Pijl, F. Roelfsema, R. Roos, 2010, Clinical endocrinology.

Arthropathy in long-term cured acromeagaly is characterised by osteophytes without joint space narrowing: a comparison with generalised osteoarthritis

J. Romijn, F. Roelfsema, J. Smit, 2010, Annals of the rheumatic diseases.

generalised osteoarthritis space narrowing : a comparison with characterised by osteophytes without joint Arthropathy in long-term cured acromeagaly is

J. Romijn, F. Roelfsema, J. Smit, 2010 .

Pulsatile LH release is diminished, whereas FSH secretion is normal, in hypocretin-deficient narcoleptic men.

S Overeem, H. Pijl, S. Overeem, 2004, American journal of physiology. Endocrinology and metabolism.

Progression of acromegalic arthropathy despite long-term biochemical control: a prospective, radiological study.

J. Romijn, F. Roelfsema, J. Smit, 2012, European journal of endocrinology.

Clinical factors involved in the recurrence of pituitary adenomas after surgical remission: a structured review and meta-analysis

Ferdinand Roelfsema, F. Roelfsema, Alberto M. Pereira, 2011, Pituitary.

Malignant prolactinoma: case report and review of the literature.

J. Romijn, F. Roelfsema, M. Kars, 2006, European journal of endocrinology.

Ten-year follow-up results of transsphenoidal microsurgery in acromegaly.

F. Roelfsema, N. Biermasz, H. Dulken, 2000, The Journal of clinical endocrinology and metabolism.

D. M. Keenan, A. Iranmanesh, J. Veldhuis, 2005, Endocrinology and metabolism clinics of North America.

Impaired LH surge amplitude in gonadotrope-specific progesterone receptor knockout mice.

U. Boehm, J. Lydon, D. Bernard, 2020, The Journal of endocrinology.

multi-center study.

F. Roelfsema, N. Kokshoorn, J. Tiemensma, 2011 .

Regulation of Pulsatile and Entropic ACTH Secretion Under Fixed Exogenous Secretagogue Clamps

P. Takahashi, J. Veldhuis, F. Roelfsema, 2017, The Journal of clinical endocrinology and metabolism.

Addition of a carboxy-terminal tail to the normally tailless gonadotropin-releasing hormone receptor impairs fertility in female mice

D. Boerboom, D. Devost, D. Bernard, 2021, eLife.

Addition of a carboxy terminal tail to the normally tailless gonadotropin-releasing hormone receptor impairs fertility in female mice

D. Boerboom, D. Devost, D. Bernard, 2021, bioRxiv.

Dynamic metabolomic data analysis: a tutorial review

A. K. Smilde, J. A. Westerhuis, H. C. J. Hoefsloot, 2009, Metabolomics.

The contribution of local thyroxine monodeiodination to intracellular 3,5, 3'-triiodothyronine in several tissues of hyperthyroid rats at isotopic equilibrium.

F. Roelfsema, J. van Doorn, D. van der Heide, 1984, Endocrinology.

Sex-dependent alteration in cortisol response to endogenous adrenocorticotropin.

J D Veldhuis, J. Veldhuis, F. Roelfsema, 1993, The Journal of clinical endocrinology and metabolism.

EXCHANGE OF TRIIODOTHYRONINE DERIVED FROM THYROXINE WITH CIRCULATING TRIIODOTHYRONINE AS STUDIED IN THE RAT *

G. D. de Escobar, M. Obregon, F. Roelfsema, 1979, Clinical endocrinology.

How are growth hormone and insulin-like growth factor-1 reported as markers for drug effectiveness in clinical acromegaly research? A comprehensive methodologic review

P. H. van der Graaf, F. Roelfsema, J. Stevens, 2018, Pituitary.

Acipimox enhances spontaneous growth hormone secretion in obese women.

H. Pijl, F. Roelfsema, A. Meinders, 2004, American journal of physiology. Regulatory, integrative and comparative physiology.

Impact of age, sex and body mass index on cortisol secretion in 143 healthy adults

A. Iranmanesh, D. van Heemst, P. Takahashi, 2017, Endocrine connections.

Acromegaly: Diagnosis & Treatment

F. Roelfsema, N. Biermasz, 2013 .

Lifetime Regulation of Growth Hormone (GH) Secretion

A. Iranmanesh, J. Veldhuis, F. Roelfsema, 2012 .

Somatotropic axis in hypocretin-deficient narcoleptic humans: altered circadian distribution of GH-secretory events.

H. Pijl, S. Overeem, A. Vein, 2003, American journal of physiology. Endocrinology and metabolism.

BROMOCRIPTINE THERAPY FOR NON‐FUNCTIONING PITUITARY ADENOMA

F. Roelfsema, D. Schaardenburg, G. Vielvoye, 1989, Clinical endocrinology.

Observation alone after transsphenoidal surgery for nonfunctioning pituitary macroadenoma.

O. Dekkers, J. Romijn, F. Roelfsema, 2006, The Journal of clinical endocrinology and metabolism.

Basal, pulsatile, entropic, and 24-hour rhythmic features of secondary hyperprolactinemia due to functional pituitary stalk disconnection mimic tumoral (primary) hyperprolactinemia.

Steven M. Pincus, J. Veldhuis, F. Roelfsema, 2001, The Journal of clinical endocrinology and metabolism.

Circadian urinary excretion rhythms in adrenalectomized rats.

F. Roelfsema, D. van der Heide, J. Poulis, 1986, The American journal of physiology.

Hypopituitarism following traumatic brain injury: prevalence is affected by the use of different dynamic tests and different normal values.

J. Romijn, F. Roelfsema, J. Smit, 2010, European journal of endocrinology.

Quality of life in treated adult craniopharyngioma patients.

O. Dekkers, J. Romijn, F. Roelfsema, 2006, European journal of endocrinology.

Prolactin release is enhanced in proportion to excess visceral fat in obese women.

H. Pijl, F. Roelfsema, A. Meinders, 2004, The Journal of clinical endocrinology and metabolism.

Increased circadian prolactin release is blunted after body weight loss in obese premenopausal women.

H. Pijl, F. Roelfsema, A. Meinders, 2006, American journal of physiology. Endocrinology and metabolism.

body weight loss in obese premenopausal women Increased circadian prolactin release is blunted after

H. Pijl, F. Roelfsema, C. C. D. Wit, 2016 .

Activation of dopamine D2 receptors simultaneously ameliorates various metabolic features of obese women.

Hanno Pijl, Ferdinand Roelfsema, Marijke Frölich, 2006, American journal of physiology. Endocrinology and metabolism.

Patients with Cushing's disease secrete adrenocorticotropin and cortisol jointly more asynchronously than healthy subjects.

J D Veldhuis, S M Pincus, Steven M. Pincus, 1998, The Journal of clinical endocrinology and metabolism.

The use of an early postoperative CRH test to assess adrenal function after transsphenoidal surgery for pituitary adenomas

J. Romijn, F. Roelfsema, J. Smit, 2011, Pituitary.

A switch from oral (2 mg/day) to transdermal (50 microg/day) 17beta-estradiol therapy increases serum insulin-like growth factor-I levels in recombinant human growth hormone (GH)-substituted women with GH deficiency.

F. Roelfsema, F. Helmerhorst, Y. J. Janssen, 2000, The Journal of clinical endocrinology and metabolism.

Quality of life is decreased after treatment for nonfunctioning pituitary macroadenoma.

O. Dekkers, J. Romijn, F. Roelfsema, 2006, The Journal of clinical endocrinology and metabolism.

Age-dependent and gender-dependent regulation of hypothalamic-adrenocorticotropic-adrenal axis.

J. Veldhuis, F. Roelfsema, Animesh N Sharma, 2013, Endocrinology and metabolism clinics of North America.

Disease‐specific impairments in quality of life during long‐term follow‐up of patients with different pituitary adenomas

H. Pijl, O. Dekkers, J. Romijn, 2008, Clinical endocrinology.

Increased episodic release and disorderliness of prolactin secretion in both micro- and macroprolactinomas.

Steven M. Pincus, J. Veldhuis, F. Roelfsema, 1999, European journal of endocrinology.

Low prevalence of hypopituitarism after traumatic brain injury: a multicenter study.

J. Romijn, F. Roelfsema, J. Smit, 2011, European journal of endocrinology.

Clinical osteoarthritis predicts physical and psychological QoL in acromegaly patients.

J. Romijn, F. Roelfsema, J. Smit, 2010, Growth hormone & IGF research : official journal of the Growth Hormone Research Society and the International IGF Research Society.

Morbidity after long-term remission for acromegaly: persisting joint-related complaints cause reduced quality of life.

J. Romijn, F. Roelfsema, J. Smit, 2005, The Journal of clinical endocrinology and metabolism.

High circulating thyrotropin levels in obese women are reduced after body weight loss induced by caloric restriction.

H. Pijl, F. Roelfsema, A. Meinders, 2005, The Journal of clinical endocrinology and metabolism.

Effects of dehydroepiandrostenedione, superimposed on growth hormone substitution, on quality of life and insulin-like growth factor I in patients with secondary adrenal insufficiency: a randomized, placebo-controlled, cross-over trial.

J. Romijn, A. V. van Hemert, F. Roelfsema, 2005, The Journal of clinical endocrinology and metabolism.

Decreased quality of life in patients with acromegaly despite long-term cure of growth hormone excess.

J. Romijn, A. V. van Hemert, F. Roelfsema, 2004, The Journal of clinical endocrinology and metabolism.

Relationships Between 24-hour LH and Testosterone Concentrations and With Other Pituitary Hormones in Healthy Older Men

D. van Heemst, F. Roelfsema, E. van der Spoel, 2021, Journal of the Endocrine Society.

GH deficiency in patients irradiated for acromegaly: significance of GH stimulatory tests in relation to the 24 h GH secretion.

A. Iranmanesh, J. Romijn, J. Veldhuis, 2006, European journal of endocrinology.

Within-Person Variation in Serum Thyrotropin Concentrations: Main Sources, Potential Underlying Biological Mechanisms, and Clinical Implications

D. van Heemst, F. Roelfsema, E. van der Spoel, 2021, Frontiers in Endocrinology.

Spontaneous diurnal thyrotropin secretion is enhanced in proportion to circulating leptin in obese premenopausal women.

H. Pijl, F. Roelfsema, A. Meinders, 2005, The Journal of clinical endocrinology and metabolism.

Human longevity is characterised by high thyroid stimulating hormone secretion without altered energy metabolism

H. Pijl, P. Slagboom, R. Westendorp, 2015, Scientific Reports.

Direct postoperative and follow-up results of transsphenoidal surgery in 19 acromegalic patients pretreated with octreotide compared to those in untreated matched controls.

F. Roelfsema, N. Biermasz, H. Dulken, 1999, The Journal of clinical endocrinology and metabolism.

Joint synchrony of reciprocal hormonal signaling in human paradigms of both ACTH excess and cortisol depletion.

Steven M. Pincus, D. M. Keenan, J. Veldhuis, 2005, American journal of physiology. Endocrinology and metabolism.

Characterization of the Hypothalamic-Pituitary-Adrenal-Axis in Familial Longevity under Resting Conditions

H. Pijl, R. Westendorp, D. van Heemst, 2015, PloS one.

Metabolic profile in growth hormone-deficient (GHD) adults after long-term recombinant human growth hormone (rhGH) therapy.

F. Roelfsema, J. Smit, N. Biermasz, 2013, The Journal of clinical endocrinology and metabolism.

Changes in muscle volume, strength, and bioenergetics during recombinant human growth hormone (GH) therapy in adults with GH deficiency.

J. Doornbos, F. Roelfsema, Y. J. Janssen, 1999, The Journal of clinical endocrinology and metabolism.

Interrelationships Between Pituitary Hormones as Assessed From 24-hour Serum Concentrations in Healthy Older Subjects

H. Pijl, P. Slagboom, R. Westendorp, 2019, The Journal of clinical endocrinology and metabolism.

Administration route-dependent effects of estrogens on IGF-I levels during fixed GH replacement in women with hypopituitarism.

J. Romijn, F. Roelfsema, E. Lentjes, 2007, European journal of endocrinology.

Increased prevalence of colonic adenomas in patients with acromegaly.

K. V. van Erpecum, G. Griffioen, H. Vasen, 1994, European journal of endocrinology.

Limited effects of growth hormone replacement in patients with GH deficiency during long-term cure of acromegaly

Jeroen J. Bax, J. Romijn, F. Roelfsema, 2009, Pituitary.

Diminished and irregular TSH secretion with delayed acrophase in patients with Cushing's syndrome.

D. M. Keenan, J. Romijn, J. Veldhuis, 2009, European journal of endocrinology.

SOMATOMEDIN‐C LEVELS IN TREATED AND UNTREATED PATIENTS WITH ACROMEGALY

F. Roelfsema, H. Dulken, M. Frölich, 1987, Clinical endocrinology.

Automated image analysis of hand radiographs reveals widened joint spaces in patients with long-term control of acromegaly: relation to disease activity and symptoms.

B. Stoel, J. Romijn, R. van ’t Klooster, 2012, European journal of endocrinology.

Sustained effects of recombinant GH replacement after 7 years of treatment in adults with GH deficiency.

O. Dekkers, J. Romijn, F. Roelfsema, 2006, European journal of endocrinology.

The exon-3 deleted growth hormone receptor polymorphism predisposes to long-term complications of acromegaly.

D. Hommes, J. Romijn, H. Guchelaar, 2009, The Journal of clinical endocrinology and metabolism.

High prevalence of vertebral fractures despite normal bone mineral density in patients with long-term controlled acromegaly.

A. Hofman, A. Uitterlinden, F. Rivadeneira, 2011, European Journal of Endocrinology.

Octreotide long-acting repeatable and lanreotide Autogel are equally effective in controlling growth hormone secretion in acromegalic patients.

J. Romijn, F. Roelfsema, E. Corssmit, 2004, European journal of endocrinology.

UvA-DARE ( Digital Academic Repository ) Network identification of hormonal regulation

A. Smilde, H. Hoefsloot, M. Hendriks, 2014 .

Thyrotropin secretion in mild and severe primary hypothyroidism is distinguished by amplified burst mass and Basal secretion with increased spikiness and approximate entropy.

E. Fliers, J. Romijn, J. Veldhuis, 2010, The Journal of clinical endocrinology and metabolism.

Analysis of bidirectional pattern synchrony of concentration-secretion pairs: implementation in the human testicular and adrenal axes.

Ferdinand Roelfsema, Steven M. Pincus, D. M. Keenan, 2005, American journal of physiology. Regulatory, integrative and comparative physiology.

Contribution fron local conversion of thyroxine to 3,5,3'-triiodothyronine to intracellular 3,5,3'-triiodothyronine in several organs in hypothyroid rats at isotope equilibrium.

F. Roelfsema, J. van Doorn, D. van der Heide, 1982, Acta endocrinologica.

Thyrotropin secretion by thyrotropinomas is characterized by increased pulse frequency, delayed diurnal rhythm, enhanced basal secretion, spikiness, and disorderliness.

D. M. Keenan, J. Romijn, J. Veldhuis, 2008, The Journal of clinical endocrinology and metabolism.

PLASMA GROWTH HORMONE PROFILES AND SLEEP: A STUDY OF 13 TREATED ACROMEGALICS

F. Roelfsema, H. Boer, A. Seters, 1989, Clinical endocrinology.

Growth Hormone Dynamics in Healthy Adults Are Related to Age and Sex and Strongly Dependent on Body Mass Index

J. Veldhuis, F. Roelfsema, 2015, Neuroendocrinology.

Growth hormone and prolactin are secreted more irregularly in patients with Cushing's disease

Steven M. Pincus, J. Veldhuis, F. Roelfsema, 2000, Clinical endocrinology.

Diurnal Secretion Profiles of Growth Hormone, Thyrotrophin and Prolactin in Parkinson’s Disease

H. Pijl, F. Roelfsema, R. Roos, 2011, Journal of neuroendocrinology.

Pretreatment insulin-like growth factor-I concentrations predict radiographic osteoarthritis in acromegalic patients with long-term cured disease.

J. Romijn, R. Wolterbeek, F. Roelfsema, 2009, The Journal of clinical endocrinology and metabolism.

Effect of administration of growth hormone on plasma and intracellular levels of thyroxine and tri-iodothyronine in thyroidectomized thyroxine-treated rats.

F. Roelfsema, P. Geelhoed-Duijvestijn, J. van Doorn, 1992, The Journal of endocrinology.

The effect of propylthiouracil and methimazole on the peripheral conversion of thyroxine to 3,5,3'-triiodothyronine in athyreotic thyroxine-maintained rats.

F. Roelfsema, J. van Doorn, D. van der Heide, 1983, Acta endocrinologica.

Dose-response downregulation within the span of single interpulse intervals.

D. M. Keenan, J. Veldhuis, F. Roelfsema, 2010, American journal of physiology. Regulatory, integrative and comparative physiology.

A novel activating mutation in the kinase homology domain of natriuretic peptide receptor-2 causes extremely tall stature without skeletal deformities

A. Uitterlinden, C. Ruivenkamp, M. Losekoot, 2013 .

Six-months of recombinant human GH therapy in patients with ischemic cardiac failure

Jeroen J. Bax, H. Lamb, E. E. van der Wall, 2004, The International Journal of Cardiovascular Imaging.

Six months of recombinant human GH therapy in patients with ischemic cardiac failure does not influence left ventricular function and mass.

Jeroen J. Bax, E. E. van der Wall, J. Romijn, 2001, The Journal of clinical endocrinology and metabolism.

Pituitary Hormone Secretion Profiles in IGSF1 Deficiency Syndrome

E. Fliers, J. Wit, D. Bernard, 2015, Neuroendocrinology.

Periodic fever associated with intermittent rhythmic delta activity: a syndrome of hypothalamic origin?

J. G. van Dijk, J. V. D. van der Meer, F. Roelfsema, 1997, Electroencephalography and clinical neurophysiology.

Circadian urinary electrolyte excretory rhythms in male and female rats

F. Roelfsema, J. Poulis, D. Heide, 1989 .

Orally disintegrating and standard olanzapine tablets similarly elevate the HOMA insulin resistance index and plasma triglyceride levels in healthy men

H. Pijl, F. Roelfsema, S. Vidarsdóttir, 2010 .

Circadian rhythms of urinary electrolyte excretion in freely moving rats.

F. Roelfsema, D. van der Heide, D. Smeenk, 1980, Life sciences.

a prospective, radiological study

F. Roelfsema, F. Roelfsema, M. Kloppenburg, 2012 .

Greater disorderliness of ACTH and cortisol release accompanies pituitary-dependent Cushing's disease.

J D Veldhuis, S M Pincus, Steven M. Pincus, 1997, European journal of endocrinology.

Reduced disorderliness of growth hormone release in biochemically inactive acromegaly after pituitary surgery.

J D Veldhuis, S M Pincus, Steven M. Pincus, 1998, European journal of endocrinology.

Endogenous ACTH concentration-cortisol secretion dose analysis unmasks decreased ACTH potency in Cushing's disease with restoration after successful pituitary adenomectomy.

D. M. Keenan, J. Veldhuis, F. Roelfsema, 2011, The Journal of clinical endocrinology and metabolism.

Familial Longevity Is Not Associated with Major Differences in the Hypothalamic–Pituitary–Gonadal Axis in Healthy Middle-Aged Men

H. Pijl, P. Slagboom, R. Westendorp, 2016, Front. Endocrinol..

Familial Longevity Is Associated With Higher TSH Secretion and Strong TSH-fT3 Relationship.

H. Pijl, P. Slagboom, R. Westendorp, 2015, The Journal of clinical endocrinology and metabolism.

Systemic energy homeostasis in Huntington's disease patients

H. Pijl, R. Roos, N. Aziz, 2010, Journal of Neurology, Neurosurgery & Psychiatry.

Rotating Day and Night Disturb Growth Hormone Secretion Profiles, Body Energy Metabolism, and Insulin Levels in Mice

F. Roelfsema, Li-li Huang, Chen Chen, 2021, Neuroendocrinology.

Running title: vertebral fractures in cured acromegaly

F. Roelfsema, M. Kloppenburg, N. Biermasz, 2011 .

Postoperative persistent thyrotrophin releasing hormone‐induced growth hormone release predicts recurrence in patients with acromegaly

F. Roelfsema, N. Biermasz, H. van Dulken, 2002, Clinical endocrinology.

IMMUNOCYTOCHEMICAL GROWTH HORMONE AND PROLACTIN IN PITUITARY ADENOMAS CAUSING ACROMEGALY AND THEIR RELATIONSHIP TO BASAL SERUM HORMONE LEVELS AND THE GROWTH RESPONSE TO THYROTROPHIN RELEASING HORMONE

F. Roelfsema, A. Kruseman, G. Bots, 1983, Clinical endocrinology.

Pre-treatment IGF-I concentrations predict radiographic osteoarthritis in acromegalic patients with long-term cured disease

J. Romijn, R. Wolterbeek, F. Roelfsema, 2009 .

Activation of dopamine D2 receptors lowers circadian leptin concentrations in obese women.

H. Pijl, J. van Pelt, F. Roelfsema, 2006, The Journal of clinical endocrinology and metabolism.

Effect of sodium oxybate on growth hormone secretion in narcolepsy patients and healthy controls.

H. Pijl, S. Overeem, N. Aziz, 2011, American journal of physiology. Endocrinology and metabolism.

1 The effect of sodium oxybate on growth hormone secretion 2 in narcolepsy patients and healthy controls 3 4 5

H. Pijl, S. Overeem, N. Aziz, 2011 .

MR, CT, and ultrasound findings of metastatic vipoma in pancreas.

G. Griffioen, F. Roelfsema, J. Jansen, 1989, Journal of computer assisted tomography.

Octreotide treatment in acromegaly: a comparison between pen-treated and pump-treated patients in a cross-over study.

A. Harris, F. Roelfsema, H. de Boer, 1991, Acta endocrinologica.

The 24-hour serum profiles of bone markers in healthy older men and women.

H. Pijl, R. Cachucho, D. van Heemst, 2019, Bone.

Females secrete growth hormone with more process irregularity than males in both humans and rats.

J D Veldhuis, S M Pincus, Steven M. Pincus, 1996, The American journal of physiology.

Basal, pulsatile, entropic (patterned), and spiky (staccato-like) properties of ACTH secretion: impact of age, gender, and body mass index.

Steven M. Pincus, D. M. Keenan, B. Carroll, 2009, The Journal of clinical endocrinology and metabolism.

Thyrotropin secretion in healthy subjects is robust and independent of age and gender, and only weakly dependent on body mass index.

H. Pijl, E. Fliers, J. Veldhuis, 2014, The Journal of clinical endocrinology and metabolism.

Increased hypothalamic-pituitary-adrenal axis activity in Huntington's disease.

H. Pijl, R. Roos, J. Romijn, 2009, The Journal of clinical endocrinology and metabolism.

Conversion of thyroxine to 3,5,3'-triiodothyronine in several rat tissues in vivo: the effect of hypothyroidism.

F. Roelfsema, J. van Doorn, D. van der Heide, 1986, Acta endocrinologica.

Short-term treatment with bromocriptine improves impaired circadian growth hormone secretion in obese premenopausal women.

H. Pijl, J. van Pelt, F. Roelfsema, 2008, The Journal of clinical endocrinology and metabolism.

Orally disintegrating and oral standard olanzapine tablets similarly elevate the homeostasis model assessment of insulin resistance index and plasma triglyceride levels in 12 healthy men: a randomized crossover study.

H. Pijl, F. Roelfsema, S. Vidarsdóttir, 2010, The Journal of clinical psychiatry.

Enhanced circadian ACTH release in obese premenopausal women: reversal by short-term acipimox treatment.

H. Pijl, F. Roelfsema, M. Stokkel, 2004, American journal of physiology. Endocrinology and metabolism.

Hyperleptinemia in women with Cushing's disease is driven by high-amplitude pulsatile, but orderly and eurhythmic, leptin secretion.

Steven M. Pincus, J. Veldhuis, F. Roelfsema, 2001, European Journal of Endocrinology.

Hypopituitarism following Traumatic Brain Injury

J. Romijn, F. Roelfsema, N. Biermasz, 2009 .

Leptin secretion rate increases with higher CAG repeat number in Huntington’s disease patients

H. Pijl, R. Roos, F. Roelfsema, 2010, Clinical endocrinology.

The influence of continuous intragastric feeding of liquid food (Vivonex) on the diurnal excretion of electrolytes and urea in rats

F. Roelfsema, D. Smeenk, D. Heide, 1982 .

Serum leptin levels during recombinant human GH therapy in adults with GH deficiency.

P. Deurenberg, F. Roelfsema, Y. J. Janssen, 1997, European journal of endocrinology.

Obesity due to melanocortin 4 receptor (MC4R) deficiency is associated with increased linear growth and final height, fasting hyperinsulinemia, and incompletely suppressed growth hormone secretion.

S. O’Rahilly, H. Pijl, I. Farooqi, 2011, The Journal of clinical endocrinology and metabolism.

Quantitation of bone and bone turnover in biopsy specimens from the iliac crest in acromegaly.

F. Roelfsema, D. Smeenk, J. C. van der Sluys, 1970, The Journal of endocrinology.

Low amplitude and disorderly spontaneous growth hormone release in obese women with or without polycystic ovary syndrome.

H. Pijl, J. Veldhuis, F. Roelfsema, 2002, The Journal of clinical endocrinology and metabolism.

Differential Effects of Estradiol and Progesterone on Cardiovascular Risk Factors in Postmenopausal Women

J. Veldhuis, F. Roelfsema, Rebecca Yang, 2018, Journal of the Endocrine Society.

Hormone secretion by pituitary adenomas is characterized by increased disorderliness and spikiness but more regular pulsing.

J. Veldhuis, F. Roelfsema, N. Biermasz, 2014, The Journal of clinical endocrinology and metabolism.

Altered setting of the pituitary-thyroid ensemble in hypocretin-deficient narcoleptic men.

H. Pijl, S. Overeem, F. Roelfsema, 2005, American journal of physiology. Endocrinology and metabolism.

Growth hormone and ghrelin secretion are associated with clinical severity in Huntington’s disease

H. Pijl, N. Aziz, F. Roelfsema, 2010, European journal of neurology.

Irregular and frequent cortisol secretory episodes with preserved diurnal rhythmicity in primary adrenal Cushing's syndrome.

J. Romijn, M. O. Aken, J. Veldhuis, 2005, The Journal of clinical endocrinology and metabolism.

hypocretin-deficient narcoleptic men Altered setting of the pituitary-thyroid ensemble in

H. Pijl, S. Overeem, F. Roelfsema, 2016 .

CLINICAL OSTEOARTHRITIS PREDICTS PHYSICAL AND PSYCHOLOGICAL QUALITY OF LIFE IN ACROMEGALY PATIENTS

J. Romijn, F. Roelfsema, J. Smit, 2010 .

Diurnal urinary calcium and phosphate excretion patterns in parathyroidectomized rats

F. Roelfsema, D. Smeenk, J. Poulis, 1983 .

Leptin, adiponectin, and resistin secretion and diurnal rhythmicity are unaltered in Parkinson's disease

H. Pijl, N. Aziz, F. Roelfsema, 2011, Movement disorders : official journal of the Movement Disorder Society.

Dynamics of the pituitary-adrenal ensemble in hypocretin-deficient narcoleptic humans: blunted basal adrenocorticotropin release and evidence for normal time-keeping by the master pacemaker.

H. Pijl, R. Strijers, S. Overeem, 2002, The Journal of clinical endocrinology and metabolism.

An activating mutation in the kinase homology domain of the natriuretic peptide receptor-2 causes extremely tall stature without skeletal deformities.

A. Verkerk, C. Ruivenkamp, H. V. van Duyvenvoorde, 2013, The Journal of clinical endocrinology and metabolism.

Endocrine pulse identification using penalized methods and a minimum set of assumptions.

Age K Smilde, Johan A Westerhuis, Jan van der Greef, 2010, American journal of physiology. Endocrinology and metabolism.

Diminished and irregular TSH secretion with delayed acrophase in patients with Cushing's syndrome.

D. M. Keenan, J. Romijn, J. Veldhuis, 2009, European journal of endocrinology.

Effect of Growth Hormone Secretagogue Receptor Deletion on Growth, Pulsatile Growth Hormone Secretion, and Meal Pattern in Male and Female Mice

N. Lebrun, M. Bohlooly-y, J. Veldhuis, 2021, Neuroendocrinology.

Plasma total ghrelin and leptin levels in human narcolepsy and matched healthy controls: basal concentrations and response to sodium oxybate.

H. Pijl, S. Overeem, F. Roelfsema, 2013, Journal of clinical sleep medicine : JCSM : official publication of the American Academy of Sleep Medicine.

Familial Longevity Is Associated With Higher TSH Secretion and Strong TSH-fT3 Relationship.

H. Pijl, R. Westendorp, D. van Heemst, 2015, The Journal of clinical endocrinology and metabolism.

Gender, age, body mass index, and IGF-I individually and jointly determine distinct GH dynamics: analyses in one hundred healthy adults.

Steven M. Pincus, D. M. Keenan, J. Veldhuis, 2011, The Journal of clinical endocrinology and metabolism.

Six-months of recombinant human GH therapy in patients with ischemic cardiac failure

Jeroen J. Bax, H. Lamb, E. E. van der Wall, 2004, The International Journal of Cardiovascular Imaging.

Six months of recombinant human GH therapy in patients with ischemic cardiac failure does not influence left ventricular function and mass.

H. Lamb, F. Roelfsema, M. Stokkel, 2001, The Journal of clinical endocrinology and metabolism.

Malignant prolactinoma: case report and review of the literature.

J. Romijn, F. Roelfsema, M. Kars, 2006, European journal of endocrinology.

Hyperleptinemia in women with Cushing's disease is driven by high-amplitude pulsatile, but orderly and eurhythmic, leptin secretion.

Steven M. Pincus, J. Veldhuis, F. Roelfsema, 2001, European journal of endocrinology.

The prevalence of the metabolic syndrome is increased in patients with GH deficiency, irrespective of long-term substitution with recombinant human GH.

E. Feskens, H. Pijl, J. Romijn, 2007, European journal of endocrinology.

Metabolic profile in growth hormone-deficient (GHD) adults after long-term recombinant human growth hormone (rhGH) therapy.

F. Roelfsema, J. Smit, N. Biermasz, 2013, The Journal of clinical endocrinology and metabolism.

Clinical osteoarthritis predicts physical and psychological QoL in acromegaly patients.

F. Roelfsema, M. Kloppenburg, N. Biermasz, 2010, Growth hormone & IGF research : official journal of the Growth Hormone Research Society and the International IGF Research Society.

Increased hypothalamic-pituitary-adrenal axis activity in Huntington's disease.

H. Pijl, R. Roos, J. Romijn, 2009, The Journal of clinical endocrinology and metabolism.

Hormone pulsatility discrimination via coarse and short time sampling

Steven M. Pincus, M. Thorner, J. Veldhuis, 1999 .

Regulatory aspects of the human hypothalamus-pituitary-thyroid axis.

A. Kalsbeek, E. Fliers, F. Roelfsema, 2017, Best practice & research. Clinical endocrinology & metabolism.

Proinflammatory Cytokine Infusion Attenuates LH's Feedforward on Testosterone Secretion: Modulation by Age.

P. Takahashi, J. Veldhuis, F. Roelfsema, 2016, The Journal of clinical endocrinology and metabolism.

1 2 Diminished and Irregular Thyrotropin Secretion with Delayed Acrophase in 3 Patients with Cushing's Syndrome 4 . 5

J. Veldhuis, F. Roelfsema, N. Biermasz, 2009 .