S. Mackenzie

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The effect of N‐acetylcysteine on oxygen transport and uptake in patients with fulminant hepatic failure

P. Hopton, T. Walsh, B. Philips, 1998, Hepatology.

Sub‐family selective actions in the ability of Erk2 MAP kinase to phosphorylate and regulate the activity of PDE4 cyclic AMP‐specific phosphodiesterases

G. Baillie, M. Houslay, S. Mackenzie, 2000, British journal of pharmacology.

From severity scores to health gain–a difficult road but one worth traveling

S. Mackenzie, S. Kendrick, J. C. Howie, 2000 .

Phosphodiesterase 4 cAMP phosphodiesterases as targets for novel anti‐inflammatory therapeutics

S. Mackenzie, 2004 .

A rehabilitation intervention to promote physical recovery following intensive care: a detailed description of construct development, rationale and content together with proposed taxonomy to capture processes in a randomised controlled trial

J. Forbes, T. Walsh, S. Brett, 2014, Trials.

Propofol infusion for control of status epilepticus

F. Kapadia, S. Mackenzie, I. Grant, 1990, Anaesthesia.

Stimulation of p70S6 kinase via a growth hormone-controlled phosphatidylinositol 3-kinase pathway leads to the activation of a PDE4A cyclic AMP-specific phosphodiesterase in 3T3-F442A preadipocytes.

M. Houslay, S. Mackenzie, G. Bolger, 1998, Proceedings of the National Academy of Sciences of the United States of America.

Measuring Hospital-Wide Mortality—Pitfalls and Potential

R. Perla, D. Goldmann, G. Parry, 2016, Journal for healthcare quality : official publication of the National Association for Healthcare Quality.

A randomised controlled trial evaluating a rehabilitation complex intervention for patients following intensive care discharge: the RECOVER study

S. Lewis, J. Forbes, T. Walsh, 2012, BMJ Open.

A randomised controlled trial evaluating a rehabilitation complex intervention for patients following intensive care discharge: the RECOVER study

S. Lewis, J. Forbes, T. Walsh, 2012, BMJ Open.

C 5 a Mediates Peripheral Blood Neutrophil Dysfunction in Critically Ill Patients

T. S. Wilkinson, T. Walsh, K. Dhaliwal, 2012 .

Glucocorticoid receptor α:β ratio in blood mononuclear cells is reduced in cigarette smokers

N. Thomson, R. Chaudhuri, A. McMahon, 2004 .

Cyclic nucleotide signalling : a molecular approach to drug discovery for Alzheimer's disease

S. Mackenzie, I. Mcphee, D. Spinks, 2005 .

C5a mediates peripheral blood neutrophil dysfunction in critically ill patients.

T. S. Wilkinson, T. Walsh, K. Dhaliwal, 2009, American journal of respiratory and critical care medicine.

Intracellular compartmentalization of PDE4 cyclic AMP-specific phosphodiesterases.

M. Houslay, S. Mackenzie, E. Huston, 1998, Methods.

Glucocorticoid receptor alpha:beta ratio in blood mononuclear cells is reduced in cigarette smokers.

N. Thomson, R. Chaudhuri, A. McMahon, 2004, The Journal of allergy and clinical immunology.

The MAP kinase ERK2 inhibits the cyclic AMP‐specific phosphodiesterase HSPDE4D3 by phosphorylating it at Ser579

G. Baillie, M. Houslay, S. Mackenzie, 1999, The EMBO journal.

Pneumocystis Carinii Pneumonia in Thymoma with Hypogammaglobulinaemia: Successful Outcome of Therapy Including IV IgG Replacement

P. Yap, P. Williams, S. Mackenzie, 1991, Scottish Medical Journal.

Haemodynamic and oxygen transport effects of propofol infusion in critically ill adults

S. Mackenzie, I. Grant, G. Nimmo, 1994, Anaesthesia.

Rhodanine derivatives as novel inhibitors of PDE4.

S. Mackenzie, G. Patrick, M. Irvine, 2008, Bioorganic & medicinal chemistry letters.

ERK2 Mitogen-activated Protein Kinase Binding, Phosphorylation, and Regulation of the PDE4D cAMP-specific Phosphodiesterases

G. Baillie, M. Houslay, S. Mackenzie, 2000, The Journal of Biological Chemistry.

The MAP kinase ERK 2 inhibits the cyclic AMP-specific phosphodiesterase HSPDE 4 D 3 by phosphorylating it at Ser 579

G. Baillie, M. Houslay, R. Hoffmann, 2013 .

Comparison of recovery from anaesthesia induced in children with either propofol or thiopentone.

N. Morton, S. Mackenzie, C. Runcie, 1993, British journal of anaesthesia.

The haemodynamic effects of intermittent haemofiltration in critically ill patients

S. Mackenzie, G. Nimmo, I. Grant, 2005, Intensive Care Medicine.

The relationship of blood lactate concentrations, oxygen delivery and oxygen consumption in septic shock and the adult respiratory distress syndrome

S. Mackenzie, I. Grant, G. Nimmo, 1992, Anaesthesia.

Oxygen delivery and oxygen consumption

S. Mackenzie, G. Nimmo, I. Grant, 1993 .

Phosphodiesterase 4 cAMP phosphodiesterases as

S. Mackenzie, 2010 .

Red cell transfusion practice following the transfusion requirements in critical care (TRICC) study: prospective observational cohort study in a large UK intensive care unit

T. Walsh, S. Mackenzie, D. Mcclelland, 2003, Vox sanguinis.

Action of rolipram on specific PDE4 cAMP phosphodiesterase isoforms and on the phosphorylation of cAMP-response-element-binding protein (CREB) and p38 mitogen-activated protein (MAP) kinase in U937 monocytic cells.

M. Houslay, S. Mackenzie, 2000, The Biochemical journal.

The effect of oxidative stress on macrophages and lung epithelial cells: the role of phosphodiesterases 1 and 4.

David M. Brown, K. Donaldson, S. Mackenzie, 2007, Toxicology letters.

Mortality and quality of life in the five years after severe sepsis

B. Cuthbertson, S. Mackenzie, A. Elders, 2013, Critical Care.

Long PDE4 cAMP specific phosphodiesterases are activated by protein kinase A‐mediated phosphorylation of a single serine residue in Upstream Conserved Region 1 (UCR1)

Ian McPhee, G. Baillie, M. Houslay, 2002, British journal of pharmacology.

The inhibitory profile of Ibudilast against the human phosphodiesterase enzyme family.

S. Mackenzie, I. Mcphee, A. Mackenzie, 2006, European journal of pharmacology.

An Intron Is Required for Dihydrofolate Reductase Protein Stability*

V. Noé, C. Ciudad, S. Mackenzie, 2003, Journal of Biological Chemistry.

Diagnostic importance of pulmonary interleukin-1β and interleukin-8 in ventilator-associated pneumonia

T. S. Wilkinson, T. Walsh, K. Dhaliwal, 2009, Thorax.

Increased Hospital-Based Physical Rehabilitation and Information Provision After Intensive Care Unit Discharge: The RECOVER Randomized Clinical Trial.

Guro Huby, Ashma Krishan, Joel Smith, 2015, JAMA internal medicine.

Phorbol 12-myristate 13-acetate triggers the protein kinase A-mediated phosphorylation and activation of the PDE4D5 cAMP phosphodiesterase in human aortic smooth muscle cells through a route involving extracellular signal regulated kinase (ERK).

G. Baillie, M. Houslay, S. Mackenzie, 2001, Molecular pharmacology.

Protein kinase C isoforms play differential roles in the regulation of adipocyte differentiation.

M. Houslay, N. Anderson, S. Mackenzie, 1998, The Biochemical journal.

Stem Cell-Derived Human Neurons in CNS Drug Discovery

A. Nunn, S. Mackenzie, C. Verastegui, 2010 .

Growth hormone and phorbol esters require specific protein kinase C isoforms to activate mitogen-activated protein kinases in 3T3-F442A cells.

M. Houslay, N. Anderson, S. Mackenzie, 1997, The Biochemical journal.

Should perioperative management target oxygen delivery

S. Mackenzie, 2003 .

Critical incidents in the intensive therapy unit

S. Mackenzie, D. Wright, S. J. Mackenzie, 1991, The Lancet.

Temporal changes in the epidemiology, management, and outcome from acute respiratory distress syndrome in European intensive care units: a comparison of two large cohorts

Fernando M. Maroto, C. Sprung, A. Nica, 2021, Critical Care.

Hyperlactatemia and pulmonary lactate production in patients with fulminant hepatic failure.

T. Walsh, A. Lee, S. McLellan, 1999, Chest.

2-Aryl-3,3,3-trifluoro-2-hydroxypropionic acids: a new class of protein tyrosine phosphatase 1B inhibitors.

S. Mackenzie, D. Adams, S. Mackay, 2007, Bioorganic & medicinal chemistry letters.

Cyclic nucleotide signalling: a molecular approach to drug discovery for Alzheimer's disease.

S. Mackenzie, I. Mcphee, D. Spinks, 2005, Biochemical Society transactions.

Should the pre‐sedation Glasgow Coma Scale value be used when calculating Acute Physiology and Chronic Health Evaluation scores for sedated patients?

S. Mackenzie, B M Livingston, S J Mackenzie, 2000, Critical care medicine.

Audit of Intensive Care Units in Scotland.

S. Mackenzie, 2005 .

Scottish Intensive Care Society Audit Group

S. Mackenzie, 2003 .

The effect of selective phosphodiesterase inhibitors, alone and in combination, on a murine model of allergic asthma

S. Mackenzie, A. Mackenzie, R. Clayton, 2004, Respiratory research.

Adrenaline in treatment of septic shock: Effects on haemodynamics and oxygen transport

F. Kapadia, S. Mackenzie, G. Nimmo, 2005, Intensive Care Medicine.

Cyclic Nucleotide Phosphodiesterase Assay Technology

S. Mackenzie, C. Wells, S. F. Hastings, 2010, Current protocols in pharmacology.

Anaesthesia and Intensive Care for Organ Transplantation

S. Mackenzie, 2000 .

The diversity of leucocyte IgA receptors.

M. Kerr, S. Mackenzie, M. R. Greer, 1995, Contributions to Nephrology.

Intracellular targeting, interaction with Src homology 3 (SH3) domains and rolipram-detected conformational switches in cAMP-specific PDE4A phosphodiesterase.

M. Houslay, G. Rena, S. Mackenzie, 1997, Biochemical Society transactions.

Propofol sedation using DiprifusorTM target‐controlled infusion in adult intensive care unit patients *

J. Glen, F. Servin, S. Mackenzie, 2004, Anaesthesia.

IgM monoclonal antibodies recognizing Fc alpha R but not Fc gamma RIII trigger a respiratory burst in neutrophils although both trigger an increase in intracellular calcium levels and degranulation.

M. Kerr, S. Mackenzie, 1995, The Biochemical journal.

IgM monoclonal antibodies recognizing FcaR but not FcyRIll trigger a respiratory burst in neutrophils although both trigger an increase in intracellular calcium levels and degranulation

M. Kerr, S. Mackenzie, 2005 .

The effect of selective phosphodiesterase inhibitors, alone and in combination, on a murine model of allergic asthma

S. Mackenzie, A. Mackenzie, R. Clayton, 2004, Respiratory research.

Lactate and acid base changes in the critically ill.

S. Mackenzie, G. Nimmo, I. Grant, 1991, Postgraduate medical journal.

Measuring Hospital-Wide Mortality—Pitfalls and Potential

R. Perla, D. Goldmann, G. Parry, 2016, Journal for healthcare quality : official publication of the National Association for Healthcare Quality.

Acid-base responses to high-volume haemofiltration in the critically ill.

S. Mackenzie, G. Nimmo, I. Grant, 1993, Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association.