C. Irvin

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Genome-Wide Association Analysis in Asthma Subjects Identifies SPATS2L as a Novel Bronchodilator Response Gene

Yusuke Nakamura, Scott T. Weiss, Xiaofeng Jiang, 2012, PLoS genetics.

Proceedings of the ATS workshop on refractory asthma: current understanding, recommendations, and unanswered questions. American Thoracic Society.

S. Spector, T. Casale, S. Wenzel, 2000, American journal of respiratory and critical care medicine.

Characteristics of patients with seasonal allergic rhinitis and concomitant asthma

W. Busse, A. Harris, H. Boushey, 2004, Clinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology.

Using the mouse to model asthma: the cup is half full and then some

C. Irvin, 2008, Clinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology.

Quantitative CT predicts the severity of physiologic dysfunction in patients with lymphangioleiomyomatosis.

J D Newell, T E King, D A Lynch, 1996, Chest.

Quantitative chest computed tomography as a means of predicting exercise performance in severe emphysema.

J D Newell, B. Make, J. Newell, 1995, Academic radiology.

Variability of methacholine bronchoprovocation and the effect of inhaled corticosteroids in mild asthma.

David M. Shade, M. Castro, E. Sugar, 2014, Annals of allergy, asthma & immunology : official publication of the American College of Allergy, Asthma, & Immunology.

Association of corticotropin-releasing hormone receptor-2 genetic variants with acute bronchodilator response in asthma

J. Xu, S. Weiss, A. Litonjua, 2008, Pharmacogenetics and genomics.

Attenuation of lung fibrosis in mice with a clinically relevant inhibitor of glutathione-S-transferase π.

D. Townsend, K. Tew, C. Wolf, 2016, JCI insight.

Dysregulation of the glutaredoxin/S-glutathionylation redox axis in lung diseases.

C. Irvin, Y. Janssen-Heininger, J. L. van der Velden, 2019, American journal of physiology. Cell physiology.

Human pulmonary resistance: effect of frequency and gas physical properties.

J. Webster, J. Dempsey, C. Irvin, 1979, Journal of applied physiology: respiratory, environmental and exercise physiology.

Technical standards for respiratory oscillometry

David W. Kaczka, J. Bates, G. Maksym, 2019, European Respiratory Journal.

Development of Eosinophilic Airway Inflammation and Airway Hyperresponsiveness in Mast Cell–deficient Mice

E. Gelfand, E. Hamelmann, A. Joetham, 1997, The Journal of experimental medicine.

Unrestrained plethysmography is an unreliable measure of airway responsiveness in BALB/c and C57BL/6 mice.

A. Adler, C. Irvin, G. Cieslewicz, 2004, Journal of applied physiology.

The use and misuse of Penh in animal models of lung disease.

P. Paré, J. Fredberg, P. Macklem, 2004, American journal of respiratory cell and molecular biology.

bronchoconstriction in mice with airway inflammation Nonlinearity of respiratory mechanics during

Mark S. Sundrud, H. T. Moriya, J. Bates, 2015 .

What Long-Term Changes in Lung Function Can Tell Us About Asthma Control

C. Irvin, D. Kaminsky, 2015, Current Allergy and Asthma Reports.

American Thoracic Society Documents an Official Ats Conference Proceedings: Advances in Small-animal Imaging Application to Lung Pathophysiology Executive Summary Background Methods Small-animal Models of Lung Disease Asthma Models Copd Interstitial Lung Disease Acute Lung Injury Imaging Modalities

D. Cody, R. Rizi, A. Wu, 2022 .

Promise and pitfalls in animal-based asthma research

D. Corry, C. Irvin, 2006, Immunologic research.

Airway epithelial specific deletion of Jun-N-terminal kinase 1 attenuates pulmonary fibrosis in two independent mouse models

J. Alcorn, Roger J. Davis, C. Irvin, 2020, PloS one.

c-Jun N-terminal kinase 1 is required for the development of pulmonary fibrosis.

J. Alcorn, C. Irvin, A. Brown, 2009, American journal of respiratory cell and molecular biology.

Bronchial challenge: just do it!

C. Irvin, 2003, Respiratory care.

A Prominent Role for Airway Epithelial NF-κB Activation in Lipopolysaccharide-Induced Airway Inflammation1

C. Irvin, Y. Janssen-Heininger, M. Poynter, 2003, The Journal of Immunology.

The safety of inactivated influenza vaccine in adults and children with asthma.

J. Fish, M. Castro, J. Tonascia, 2001, The New England journal of medicine.

Glutaredoxin deficiency promotes activation of the transforming growth factor beta pathway in airway epithelial cells, in association with fibrotic airway remodeling

C. Irvin, J. Nolin, Y. Janssen-Heininger, 2020, Redox biology.

Reducing protein oxidation reverses lung fibrosis

N. Kaminski, R. Hakem, K. Brown, 2018, Nature Medicine.

Nasal beclomethasone prevents the seasonal increase in bronchial responsiveness in patients with allergic rhinitis and asthma.

C. Irvin, J. Corren, A. Adinoff, 1992, The Journal of allergy and clinical immunology.

Recruitment of participants in the childhood Asthma Management Program (CAMP). I. Description of methods: Childhood Asthma Management Program Research Group.

Thomas F. Smith, T. F. Smith, C. Rand, 1999, The Journal of asthma : official journal of the Association for the Care of Asthma.

Physiologic evaluation of bullous emphysema.

J. F. Wade, C. Irvin, R. Mortenson, 1991, Chest.

Hard-rock mining exposures affect smokers and nonsmokers differently. Results of a community prevalence study.

D. Lezotte, K. Kreiss, C. Irvin, 1989, The American review of respiratory disease.

Absence of c-Jun NH2-terminal kinase 1 protects against house dust mite-induced pulmonary remodeling but not airway hyperresponsiveness and inflammation.

J. Alcorn, C. Irvin, Y. Janssen-Heininger, 2014, American journal of physiology. Lung cellular and molecular physiology.

Lymphangioleiomyomatosis: the pathophysiology of diminished exercise capacity.

L. Ackerson, C. Irvin, T. King, 1996, American journal of respiratory and critical care medicine.

Changes in bronchial responsiveness following nasal provocation with allergen.

C. Irvin, J. Corren, A. Adinoff, 1992, The Journal of allergy and clinical immunology.

Role of H1 and H2 receptors in increased small airways resistance in the dog.

J. Dempsey, C. Irvin, 1978, Respiration physiology.

Nitrogen dioxide enhances allergic airway disease

N. Heintz, C. Irvin, W. Blay, 2005 .

Classifying the Severity of COPD: Are We There Yet? Editorial for “Coton, S. et al. Severity of Airflow Obstruction in Chronic Obstructive Pulmonary Disease (COPD): Proposal for a New Classification”

C. Irvin, 2017, COPD.

Tumor necrosis factor-alpha overexpression in lung disease: a single cause behind a complex phenotype.

J. Bates, M. J. Sullivan, C. Irvin, 2005, American journal of respiratory and critical care medicine.

Montelukast and Theophylline: No Use or Some Use in Persistent Asthma?

N. Anthonisen, R. Wise, N. Hanania, 2007 .

Strain dependence of airway hyperresponsiveness reflects differences in eosinophil localization in the lung.

C. Irvin, K. Takeda, E. Gelfand, 2001, American journal of physiology. Lung cellular and molecular physiology.

Nitration-Nitrosylation and Tyrosine S Protein Disease , in Association with Increases in Inflammation in Mice with Allergic Airway Inhibition of Arginase Activity Enhances

Yvonne, A. Lundblad, C. Irvin, 2008 .

A role for sensory nerves in the late asthmatic response

P. O'Byrne, J. Fozard, M. Belvisi, 2011, Thorax.

Nuclear factor kappaB, airway epithelium, and asthma: avenues for redox control.

C. Irvin, Y. Janssen-Heininger, J. L. van der Velden, 2009, Proceedings of the American Thoracic Society.

Inhibition of Arginase Activity Enhances Inflammation in Mice with Allergic Airway Disease, in Association with Increases in Protein S-Nitrosylation and Tyrosine Nitration1

C. Irvin, Y. Janssen-Heininger, A. van der Vliet, 2008, The Journal of Immunology.

IL‐1/inhibitory &kgr;B kinase &egr;–induced glycolysis augment epithelial effector function and promote allergic airways disease

E. Wouters, P. Vacek, A. Dixon, 2017, The Journal of allergy and clinical immunology.

Interleukin-1/inhibitory kappa B kinase epsilon-induced glycolysisaugment epithelial effector function and promote allergic airwaysdisease

C. Irvin, D. Hoagland, M. Henket, 2018 .

Dysregulation of Pyruvate Kinase M2 Promotes Inflammation in a Mouse Model of Obese Allergic Asthma.

A. Dixon, C. Irvin, Y. Janssen-Heininger, 2021, American journal of respiratory cell and molecular biology.

The Physiology of Asthma-Chronic Obstructive Pulmonary Disease Overlap.

C. Irvin, D. Kaminsky, 2022, Immunology and allergy clinics of North America.

CD23 exhibits negative regulatory effects on allergic sensitization and airway hyperresponsiveness.

D. Conrad, E. Gelfand, James J. Lee, 2000, American journal of respiratory and critical care medicine.

Aerosolized antigen exposure without adjuvant causes increased IgE production and increased airway responsiveness in the mouse.

E. Gelfand, H. R. Smith, C. Irvin, 1992, The Journal of allergy and clinical immunology.

Overexpression of tumor necrosis factor-alpha produces an increase in lung volumes and pulmonary hypertension.

M. Fujita, C. Cool, C. Irvin, 2001, American journal of physiology. Lung cellular and molecular physiology.

The late, but not early, asthmatic response is dependent on IL-5 and correlates with eosinophil infiltration.

G. Cieslewicz, J. Schwarze, A. Adler, 1999, The Journal of clinical investigation.

Role of cationic proteins in the airway. Hyperresponsiveness due to airway inflammation.

W. Mitzner, C. Irvin, A. Coyle, 1994, American journal of respiratory and critical care medicine.

Increased glutaredoxin-1 and decreased protein S-glutathionylation in sputum of asthmatics

C. Brightling, E. Wouters, M. Dentener, 2012, European Respiratory Journal.

Genetic ablation of glutaredoxin-1 causes enhanced resolution of airways hyperresponsiveness and mucus metaplasia in mice with allergic airways disease.

Y. Ho, C. Irvin, J. Nolin, 2012, American journal of physiology. Lung cellular and molecular physiology.

Endoplasmic reticulum stress mediates house dust mite-induced airway epithelial apoptosis and fibrosis

A. Dixon, C. Irvin, J. Nolin, 2013, Respiratory Research.

Bradykinin-induced bronchospasm in the rat in vivo: a role for nitric oxide modulation.

C. Irvin, T. Homma, 1999, The European respiratory journal.

Anti-CD86 (B7.2) treatment abolishes allergic airway hyperresponsiveness in mice.

E. Hamelmann, G. Cieslewicz, A. Joetham, 1999, American journal of respiratory and critical care medicine.

Penetration of corticosteroids into the lung: evidence for a difference between methylprednisolone and prednisolone.

G. Larsen, S. Szefler, C. Irvin, 1989, The Journal of allergy and clinical immunology.

Cys-leukotrienes promote fibrosis in a mouse model of eosinophil-mediated respiratory inflammation.

James J. Lee, Wen Li, Hua-Hao Shen, 2013, American journal of respiratory cell and molecular biology.

Frontline Science: Eosinophil‐deficient MBP‐1 and EPX double‐knockout mice link pulmonary remodeling and airway dysfunction with type 2 inflammation

James J. Lee, C. Irvin, N. Lee, 2017, Journal of leukocyte biology.

Pulmonary Physiology of Severe Asthma in Children and Adults

G. Kerby, G. Larsen, C. Irvin, 2001 .

Hyperpnea-induced changes in parenchymal lung mechanics in normal subjects and in asthmatics.

S. Wenzel, C. Irvin, D. Kaminsky, 1997, American journal of respiratory and critical care medicine.

Sinusitis and asthma: an animal model.

C. Irvin, 1992, The Journal of allergy and clinical immunology.

Improvements in distal lung function correlate with asthma symptoms after treatment with oral montelukast.

C. Cairns, S. Wenzel, M. Kraft, 2006, Chest.

Asthma treatment through the beta receptor: lessons from animal models.

C. Irvin, E. Riesenfeld, 2011, Frontiers in bioscience.

Physiologic dysfunction of the asthmatic lung: what's going on down there, anyway?

J. Bates, C. Irvin, 2009, Proceedings of the American Thoracic Society.

Effects of cool, dry air stimulation on peripheral lung mechanics in asthma.

J. Bates, C. Irvin, D. Kaminsky, 2000, American journal of respiratory and critical care medicine.

Interaction between the growing lung and asthma: role of early intervention.

C. Irvin, Charles G. Irvin, 2000, The Journal of allergy and clinical immunology.

Methacholine challenge does not affect bronchoalveolar fluid cell number and many indices of cell function in asthma.

S. Wenzel, R. Martin, M. Kraft, 1995, The European respiratory journal.

Physiologic Dysfunction of the Asthmatic Lung

J. Bates, C. Irvin, 2012 .

Allergic rhinitis and sinusitis in asthma: differential effects on symptoms and pulmonary function.

David M. Shade, D. Shade, R. Wise, 2006, Chest.

Older age and obesity are associated with increased airway closure in response to methacholine in patients with asthma

W. Teague, E. Sugar, R. Wise, 2019, Respirology.

Dividing the FEV1 into its component parts.

P. Macklem, C. Irvin, 2008, Journal of applied physiology.

Airway responses to a diluent used in the methacholine challenge test.

J. Wanger, D. Ikle, C. Irvin, 2001, Annals of allergy, asthma & immunology : official publication of the American College of Allergy, Asthma, & Immunology.

Ablation of Glutaredoxin-1 Modulates House Dust Mite-Induced Allergic Airways Disease in Mice.

E. Wouters, Y. Ho, A. Dixon, 2016, American journal of respiratory cell and molecular biology.

Lower Airway Disease in Asthmatics with and without Rhinitis

A. Dixon, C. Irvin, B. Suratt, 2008, Lung.

Epithelial NF-κB Orchestrates House Dust Mite–Induced Airway Inflammation, Hyperresponsiveness, and Fibrotic Remodeling

A. Dixon, C. Irvin, J. Nolin, 2013, The Journal of Immunology.

Increases in airway reactivity to histamine and inflammatory cells in bronchoalveolar lavage after the late asthmatic response in an animal model.

W. Marsh, G. Larsen, C. Irvin, 1985, The American review of respiratory disease.

Body temperature modulates the effect of platelet-activating factor (PAF) on airways responsiveness in the rabbit

M. Nieminen, C. Irvin, M. Hill, 1991, Agents and Actions.

Bimodal effect of platelet-activating factor (PAF) on airways responsiveness in the rabbit.

P. Henson, M. Nieminen, C. Irvin, 1994, Experimental lung research.

This information is current as Remodeling Hyperresponsiveness , and Fibrotic Induced Airway Inflammation , − Mite B Orchestrates House Dust κ Epithelial

Yvonne, C. Irvin, K. Black, 2013 .

Indoleamine 2,3-dioxygenase in lung dendritic cells promotes Th2 responses and allergic inflammation

D. Munn, M. Fei, A. Ray, 2008, Proceedings of the National Academy of Sciences.

Cellular FLIP Long Form-Transgenic Mice Manifest a Th2 Cytokine Bias and Enhanced Allergic Airway Inflammation 1

J. Tschopp, C. Irvin, R. Budd, 2004, The Journal of Immunology.

unconventional, but traditional, studies Heterogeneity of airway hyperresponsiveness: time for

J. Bates, M. J. Sullivan, P. Sterk, 2015 .

Cationic proteins induce airway hyperresponsiveness dependent on charge interactions.

C. Irvin, A. Coyle, S. Ackerman, 1993, The American review of respiratory disease.

Inhibition of NFAT Specifically in T Cells Prevents Allergic Pulmonary Inflammation1

C. Irvin, T. Krahl, M. Rincón, 2004, The Journal of Immunology.

Rapid activation of nuclear factor-kappaB in airway epithelium in a murine model of allergic airway inflammation.

C. Irvin, Y. Janssen-Heininger, M. Poynter, 2002, The American journal of pathology.

Cationic proteins alter smooth muscle function by an epithelium-dependent mechanism.

W. Mitzner, C. Irvin, A. Coyle, 1993, Journal of applied physiology.

HRV BIOFEEDBACK NOT A SUBSTITUTE FOR STEROID CONTROLLER MEDICATION FOR ASTHMA

Jessica L. Graves, P. Lehrer, C. Irvin, 2018 .

Nonpurinergic nature and efficacy of nonadrenergic bronchodilation.

P. Macklem, C. Irvin, R. Martin, 1982, Journal of applied physiology: respiratory, environmental and exercise physiology.

Bronchodilatation: noncholinergic, nonadrenergic mediation demonstrated in vivo in the cat.

P. Macklem, C. Irvin, R. Martin, 1980, Science.

Effect of corticosteroids on diaphragm function and biochemistry in the rabbit.

C. Irvin, R. Cherniack, G. Ferguson, 1990, The American review of respiratory disease.

Effect of corticosteroids on respiratory muscle histopathology.

C. Irvin, R. Cherniack, G. Ferguson, 1990, The American review of respiratory disease.

Early intervention of therapy in asthma

A. Dixon, C. Irvin, 2005, Current opinion in pulmonary medicine.

Airway responsiveness should be a measurement of the responsiveness of airways.

Z. Hantos, W. Mitzner, C. Irvin, 2007, American journal of respiratory and critical care medicine.

Efficacy of Nasal Mometasone for the Treatment of Chronic Sinonasal Disease in Inadequately Controlled Asthma

S. Peters, L. Gerald, E. Sugar, 2015 .

Lung volume reduction surgery. This official statement of the American Thoracic Society was adopted by the ATS Board of Directors, May 1996.

R. Casaburi, B. Make, A. Fein, 1996, American journal of respiratory and critical care medicine.

Transforming growth factor-beta1 suppresses airway hyperresponsiveness in allergic airway disease.

J. Alcorn, J. Bates, C. Irvin, 2007, American Journal of Respiratory and Critical Care Medicine.

Protein disulfide isomerase-endoplasmic reticulum resident protein 57 regulates allergen-induced airways inflammation, fibrosis, and hyperresponsiveness.

S. Erzurum, S. Comhair, P. Woodruff, 2016, The Journal of allergy and clinical immunology.

Comparability of pulmonary function results from 13 laboratories in a metropolitan area.

J. Wanger, C. Irvin, 1991, Respiratory care.

NONCHOLINERGIC, NONADRENERGIC BRONCHODILATION IN THE CAT

P. Macklem, C. Irvin, R. Martin, 1981 .

NF-kappa B activation in airways modulates allergic inflammation but not hyperresponsiveness.

P. Vacek, C. Irvin, Y. Janssen-Heininger, 2004, Journal of immunology.

infants and adults Volume history and effect on airway reactivity in

P. Paré, J. Fredberg, S. Mijailovich, 2015 .

Transforming Growth Factor-b1 Suppresses Airway Hyperresponsiveness in Allergic Airway Disease

J. Alcorn, C. Irvin, Y. Janssen-Heininger, 2007 .

The detection of collapsible airways contributing to airflow limitation.

E. Chan, C. Irvin, 1995, Chest.

5-Lipoxygenase products are necessary for ovalbumin-induced airway responsiveness in mice.

J. Sheller, C. Funk, C. Irvin, 1997, The American journal of physiology.

Methylprednisolone achieves greater concentrations in the lung than prednisolone. A pharmacokinetic analysis.

G. Larsen, S. Szefler, C. Irvin, 1991, The American review of respiratory disease.

CD23 deficient mice develop allergic airway hyperresponsiveness following sensitization with ovalbumin.

E. Hamelmann, A. Joetham, H. Kikutani, 1997, American journal of respiratory and critical care medicine.

Methacholine challenge testing: safety of low starting FEV1. Asthma Clinical Research Network (ACRN).

J. Wanger, R. Martin, C. Irvin, 1997, Chest.

Demand and continuous flow intermittent mandatory ventilation systems.

T. Neff, C. Irvin, J. L. Bowman, 1985, Chest.

T lymphocytes: Setting the tone of the airways

E. Gelfand, C. Irvin, 1997, Nature Medicine.

Relationship of diaphragm glycogen, lactate, and function to respiratory failure.

C. Irvin, R. Cherniack, G. Ferguson, 1990, The American review of respiratory disease.

The Flow-Volume Loop: Always an Inspiration!

C. Irvin, 2020, COPD.

Lessons from structure-function studies in asthma: myths and truths about what we teach.

C. Irvin, 2006, Journal of applied physiology.

Office spirometry: equipment selection and training of staff in the private practice setting.

J. Wanger, C. Irvin, 1997, Journal of Asthma.

Preface: “Imaging the Lung in 3D: Pictures with Impact”

C. Irvin, 2021, Histochemistry and Cell Biology.

Airways hyperreactivity and inflammation produced by aerosolization of human C5A des arg.

P. Henson, C. Irvin, N. Berend, 1986, The American review of respiratory disease.

Effects of Reduced Nicotine Content Cigarettes on Fractional Exhaled Nitric Oxide (FeNO) and Self-Reported Respiratory Health Outcomes among Smokers with Psychiatric Conditions or Socioeconomic Disadvantage.

Anthony C Oliver, J. Bunn, S. Higgins, 2021, Nicotine & tobacco research : official journal of the Society for Research on Nicotine and Tobacco.

Distribution of bronchoconstrictor responses in isolated-perfused rat lung.

N. Voelkel, C. Irvin, A. Leff, 1989, Journal of applied physiology.

Granulocytes and airway reactivity.

R. Martin, G. Larsen, C. Irvin, 1991, The American review of respiratory disease.

Knowledge and use of office spirometry for the detection of chronic obstructive pulmonary disease by primary care physicians: Respir Care 2005;50:1639–48

C. Irvin, T. Marcy, D. Kaminsky, 2006 .

Increased lower airways responsiveness associated with sinusitis in a rabbit model.

G. Larsen, P. Henson, C. Irvin, 1993, The American review of respiratory disease.

Airway smooth muscle dynamics: a common pathway of airway obstruction in asthma.

P. Paré, J. Fredberg, S. Mijailovich, 2007, The European respiratory journal.

Effect of lung volume maintenance during sleep in nocturnal asthma.

R. Martin, C. Irvin, J. Pak, 1993, Journal of applied physiology.

Defining a Link with Asthma in Mice Congenitally Deficient in Eosinophils

E. Lenkiewicz, James J. Lee, C. Irvin, 2004, Science.

Cationic protein-induced sensory nerve activation: role of substance P in airway hyperresponsiveness and plasma protein extravasation.

C. Irvin, A. Coyle, S. Manzini, 1994, The Journal of clinical investigation.

Lung Pathologies in a Chronic Inflammation Mouse Model Are Independent of Eosinophil Degranulation

James J. Lee, C. Irvin, N. Lee, 2017, American journal of respiratory and critical care medicine.

Influence of sleep on lung volume in asthmatic patients and normal subjects.

D. White, R. Ballard, R. Martin, 1990, Journal of applied physiology.

Guidelines for methacholine and exercise challenge testing-1999. This official statement of the American Thoracic Society was adopted by the ATS Board of Directors, July 1999.

J. Hankinson, A. Coates, R. Casaburi, 2000, American journal of respiratory and critical care medicine.

ACID ASPIRATION-INDUCED AIRWAYS HYPERRESPONSIVENESS 1 IN MICE 2

J. Bates, C. Irvin, G. Allen, 2009 .

Bronchial challenge testing.

C. Irvin, 1995, Respiratory care clinics of North America.

To blow or not to blow--that is the question.

C. Irvin, 2002, Respiratory care.

The Childhood Asthma Management Program (CAMP): design, rationale, and methods. Childhood Asthma Management Program Research Group.

Heather Eliassen, Scott T. Weiss, Babi Hammond, 1999, Controlled clinical trials.

Inflammation and Asthma

G. Larsen, C. Irvin, Mark Wilson, 1987 .

Elevation of IL-6 in the allergic asthmatic airway is independent of inflammation but associates with loss of central airway function

J. Bunn, C. Irvin, M. Rincón, 2010, Respiratory research.

Upper Respiratory Tract Disease and Asthma

C. Irvin, A. Adinoff, 1987 .

Peripheral lung mechanics may account for the rise in the maximal:partial ratio which follows hyperpnea-induced bronchospasm.

S. Wenzel, C. Irvin, D. Kaminsky, 1995, Chest.

Mechanisms of histamine-induced contraction of canine airway smooth muscle.

J. Martin, C. Irvin, T. Shenkier, 1983, Journal of applied physiology: respiratory, environmental and exercise physiology.

Useful models of asthma need to properly phenotype airway narrowing.

J. Bates, Z. Hantos, W. Mitzner, 2011, American journal of respiratory cell and molecular biology.

Airway resistance: synonyms, surrogates, and precision.

J. Bates, Z. Hantos, P. Sly, 2011, American journal of physiology. Lung cellular and molecular physiology.

Asthma outcomes: pulmonary physiology.

G. O'Connor, A. Togias, S. Peters, 2012, The Journal of allergy and clinical immunology.

Pathophysiology and Physiologic Assessment of the Asthmatic Patient

C. Irvin, R. Cherniack, 1987 .

responses of isolated airway segments from mature Comparison of elastic properties and contractile

P. Paré, J. Fredberg, S. Mijailovich, 2015 .

Reply: To PMID 25174863.

M. Castro, S. Peters, L. Gerald, 2015, The Journal of allergy and clinical immunology.

Peripheral airways responsiveness to cool, dry air in normal and asthmatic individuals.

S. Wenzel, M. C. Liu, C. Irvin, 1995, American journal of respiratory and critical care medicine.

Role of fibrin in determining airway closure.

J. Bates, C. Irvin, S. Wagers, 2003, Chest.

Effects of obesity and bariatric surgery on airway hyperresponsiveness, asthma control, and inflammation.

R. Pratley, J. Bunn, A. Dixon, 2011, The Journal of allergy and clinical immunology.

ARG1 is a novel bronchodilator response gene: screening and replication in four asthma cohorts.

E. Bleecker, A. Litonjua, C. Lange, 2008, American journal of respiratory and critical care medicine.

Pathophysiological Changes in Asthma Induced by Weight Loss

R. Pratley, A. Dixon, C. Irvin, 2012 .

Role of IL-6 in Asthma and Other Inflammatory Pulmonary Diseases

C. Irvin, M. Rincón, 2012, International journal of biological sciences.

Predicting episodes of poor asthma control in treated patients with asthma.

David M. Shade, N. Anthonisen, M. Castro, 2006, The Journal of allergy and clinical immunology.

Noninvasive measurement of airway responsiveness in allergic mice using barometric plethysmography.

E. Gelfand, E. Hamelmann, J. Schwarze, 1997, American journal of respiratory and critical care medicine.

the simpler the better? Assessment of respiratory mechanics in small animals:

J. Bates, Z. Hantos, P. Sly, 2015 .

function values in healthy mice double-chamber plethysmographic respiratory Effect of somatic growth, strain, and sex on

K. Svenson, J. Bates, Z. Hantos, 2015 .

NF-κB Activation in Airways Modulates Allergic Inflammation but Not Hyperresponsiveness1

P. Vacek, C. Irvin, Y. Janssen-Heininger, 2004, The Journal of Immunology.

Clinical trial of low-dose theophylline and montelukast in patients with poorly controlled asthma.

N. Anthonisen, M. Castro, R. Wise, 2007, American journal of respiratory and critical care medicine.

The allergic mouse model of asthma: normal smooth muscle in an abnormal lung?

Jason H T Bates, Charles G Irvin, J. Bates, 2004, Journal of applied physiology.

Mucous Obstruction and Airway Hyperresponsiveness in Mice

J. Bates, C. Irvin, G. Allen, 2008 .

Randomized trial of the effect of drug presentation on asthma outcomes: the American Lung Association Asthma Clinical Research Centers.

C. Rand, M. Sockrider, M. Castro, 2009, The Journal of allergy and clinical immunology.

Heart Rate Variability Biofeedback Does Not Substitute for Asthma Steroid Controller Medication

Jessica L. Graves, P. Lehrer, C. Irvin, 2017, Applied Psychophysiology and Biofeedback.

Time dependence of recruitment and derecruitment in the lung: a theoretical model.

Jason H T Bates, Charles G Irvin, J. Bates, 2002, Journal of applied physiology.

Effect of a soy isoflavone supplement on lung function and clinical outcomes in patients with poorly controlled asthma: a randomized clinical trial.

Lewis J Smith, E. Sugar, R. Wise, 2015, JAMA.

Clinical significance and applications of oscillometry

David W. Kaczka, G. Maksym, E. Oostveen, 2022, European Respiratory Review.

The phosphatidylinositide 3-kinase (PI3K) signaling pathway is a determinant of zileuton response in adults with asthma

M. Kubo, A. Dahlin, A. Litonjua, 2018, The Pharmacogenomics Journal.

Distal lung dysfunction at night in nocturnal asthma.

R. Martin, M. Kraft, C. Irvin, 2001, American journal of respiratory and critical care medicine.

Measuring the lung function in the mouse: the challenge of size

J. Bates, C. Irvin, Jason H. T. Bates, 2003, Respiratory research.

A genome-wide association study of bronchodilator response in asthmatics

J. Celedón, A. Litonjua, W. Qiu, 2013, The Pharmacogenomics Journal.

Tumor Necrosis Factor–α Overexpression in Lung Disease

J. Bates, C. Irvin, M. Poynter, 2005 .

TH17 Cells Mediate Steroid-Resistant Airway Inflammation and Airway Hyperresponsiveness in Mice1

J. Alcorn, A. Ray, J. Kolls, 2008, The Journal of Immunology.

Genome-Wide Association Study Identifies Novel Pharmacogenomic Loci For Therapeutic Response to Montelukast in Asthma

M. Kubo, A. Dahlin, A. Litonjua, 2015, PloS one.

Regulatory haplotypes in ARG1 are associated with altered bronchodilator response.

E. Bleecker, A. Litonjua, S. Liggett, 2011, American journal of respiratory and critical care medicine.

Development of a Pharmacogenetic Predictive Test in asthma: proof of concept

A. Litonjua, C. Lange, B. Himes, 2010, Pharmacogenetics and genomics.

Absorption of montelukast is transporter mediated: a common variant of OATP2B1 is associated with reduced plasma concentrations and poor response

J. Lima, C. Irvin, E. Mougey, 2009, Pharmacogenetics and genomics.

University of Groningen Integration of mouse and human genome-wide association data identifies KCNIP 4 as an asthma gene

Keith S. Sheppard, Christopher R. Gignoux, D. Postma, 2017 .

Integration of Mouse and Human Genome-Wide Association Data Identifies KCNIP4 as an Asthma Gene

Keith S. Sheppard, Christopher R. Gignoux, D. Postma, 2013, PloS one.

A polymorphism in the thyroid hormone receptor gene is associated with bronchodilator response in asthmatics

A. Litonjua, R. Du, S. Liggett, 2011, The Pharmacogenomics Journal.

Cationic proteins increase the permeability of cultured rabbit tracheal epithelial cells: modification by heparin and extracellular calcium.

C. Irvin, G. Cott, D. Uchida, 1996, Experimental lung research.

Asthma in the elderly: Current understanding and future research needs—a report of a National Institute on Aging (NIA) workshop

B. Yawn, E. Halm, K. Patel, 2011, Journal of Allergy and Clinical Immunology.

Genome-wide association study identifies three new susceptibility loci for adult asthma in the Japanese population

Yusuke Nakamura, Tatsuhiko Tsunoda, Scott T. Weiss, 2011, Nature Genetics.

Cholinergic mechanisms involved with histamine hyperreactivity in immune rabbit airways challenged with ragweed antigen.

G. Larsen, C. Irvin, R. Ando, 1991, The American review of respiratory disease.

Acid aspiration-induced airways hyperresponsiveness in mice.

J. Bates, C. Irvin, G. Allen, 2009, Journal of applied physiology.

An official ATS clinical practice guideline: interpretation of exhaled nitric oxide levels (FENO) for clinical applications.

Margaret W Leigh, Raed A Dweik, Charles G Irvin, 2011, American journal of respiratory and critical care medicine.

Respiratory mechanics of the coatimundi and woodchuck.

C. Irvin, D. Boggs, 1992, Respiration physiology.

DUOX1 mediates persistent epithelial EGFR activation, mucous cell metaplasia, and airway remodeling during allergic asthma.

A. Dixon, C. Irvin, Y. Janssen-Heininger, 2016, JCI insight.

Extravascular fibrin, plasminogen activator, plasminogen activator inhibitors, and airway hyperresponsiveness.

J. Bates, B. Sobel, C. Irvin, 2004, The Journal of clinical investigation.

Peripheral lung responsiveness assessed by forced oscillations through the wedged bronchoscope.

H. T. Moriya, J. Bates, C. Irvin, 2003, Chest.

Development of eosinophilic airway inflammation and airway hyperresponsiveness requires interleukin-5 but not immunoglobulin E or B lymphocytes.

E. Gelfand, E. Hamelmann, J. Schwarze, 1999, American journal of respiratory cell and molecular biology.

Airway Hyperresponsiveness and Inflammation: Causation, Correlation, or No Relation?

J. Alcorn, J. Kolls, C. Irvin, 2012, Journal of allergy & therapy.

Jun N-terminal kinase 1 regulates epithelial-to-mesenchymal transition induced by TGF-β1

J. Alcorn, C. Irvin, Y. Janssen-Heininger, 2008, Journal of Cell Science.

Intrinsic and antigen-induced airway hyperresponsiveness are the result of diverse physiological mechanisms.

J. Bates, C. Irvin, S. Wagers, 2007, Journal of applied physiology.

Transforming Growth Factor-β1 Suppresses Airway Hyperresponsiveness in Allergic Airway Disease

J. Alcorn, J. Bates, C. Irvin, 2007 .

Effect of cooling on the responsiveness of canine tracheal muscle.

C. Irvin, S. Curtis, A. Leff, 1990, The American review of respiratory disease.

Animal models of asthma.

J. Bates, C. Irvin, M. Rincón, 2009, American journal of physiology. Lung cellular and molecular physiology.

Nitrogen dioxide enhances allergic airway inflammation and hyperresponsiveness in the mouse.

N. Heintz, C. Irvin, W. Blay, 2006, American journal of physiology. Lung cellular and molecular physiology.

Complex systems in pulmonary medicine: a systems biology approach to lung disease.

Peter J Sterk, Charles G Irvin, P. Sterk, 2011, Journal of applied physiology.

Airway hyperresponsiveness in allergically inflamed mice: the role of airway closure.

J. Bates, C. Irvin, G. Allen, 2007, American journal of respiratory and critical care medicine.

Timing of administration of anti-VLA-4 differentiates airway hyperresponsiveness in the central and peripheral airways in mice.

A. Joetham, C. Irvin, K. Takeda, 2000, American journal of respiratory and critical care medicine.

Heart Rate Variability Biofeedback Does Not Substitute for Asthma Steroid Controller Medication

P. Lehrer, Shou-En Lu, C. Irvin, 2018, Applied psychophysiology and biofeedback.

Inhaled salmeterol and/or fluticasone alters structure/function in a murine model of allergic airways disease

J. Bates, C. Irvin, H. Haverkamp, 2010, Respiratory research.

Randomized comparison of strategies for reducing treatment in mild persistent asthma.

N. Anthonisen, M. Castro, S. Peters, 2007, The New England journal of medicine.

TH 17 Cells Mediate Steroid-Resistant Airway Inflammation and Airway Hyperresponsiveness in Mice 1

J. Alcorn, A. Ray, J. Kolls, 2008 .

Pneumomediastinum and pneumoretroperitoneum.

C. Irvin, R. Crausman, E. M. Klinge, 1995, The American journal of emergency medicine.

Reducing protein oxidation reverses lung fibrosis

N. Kaminski, R. Hakem, K. Brown, 2018, Nature Medicine.

Human eosinophil-granule major basic protein and synthetic polycations induce airway hyperresponsiveness in vivo dependent on bradykinin generation.

D. Proud, C. Irvin, A. Coyle, 1995, The Journal of clinical investigation.

Methacholine challenge test: diagnostic characteristics in asthmatic patients receiving controller medications.

David M. Shade, M. Castro, E. Sugar, 2012, The Journal of allergy and clinical immunology.

Chapter 8 – Eosinophil Secretory Functions

P. Bozza, C. Irvin, J. Butterfield, 2013 .

Conjugated bile acids attenuate allergen-induced airway inflammation and hyperresposiveness by inhibiting UPR transducers.

S. Amin, D. Desai, Amit Kumar, 2019, JCI insight.

Breathing In: The Determinants of Lung Volume

J. Wanger, C. Irvin, 2018 .

Airways hyperresponsiveness: a perspective from 15,000 ft.

C. Irvin, 2010, Journal of applied physiology.

Obesity in children with poorly controlled asthma: Sex differences

David M. Shade, W. Teague, D. Shade, 2013, Pediatric pulmonology.

The effect of human eosinophil granule major basic protein on airway responsiveness in the rat in vivo. A comparison with polycations.

G. Larsen, C. Irvin, A. Coyle, 1993, The American review of respiratory disease.

Exercise for fun and profit: joint statement on exercise by the American Thoracic Society and the American College of Chest Physicians.

C. Irvin, D. Kaminsky, 2004, Chest.

Pulmonary histiocytosis X: pulmonary function and exercise pathophysiology.

L. Ackerson, R. Tuder, C. Irvin, 1996, American journal of respiratory and critical care medicine.

It's not all smooth muscle: non-smooth-muscle elements in control of resistance to airflow.

C. Irvin, Y. Bossé, E. Riesenfeld, 2010, Annual review of physiology.

Influence of distinct asthma phenotypes on lung function following weight loss in the obese

J. Bates, A. Dixon, C. Irvin, 2014, Respirology.

Allergic Airways Disease in the Mouse Catalase Overexpression Fails to Attenuate

E. Wouters, C. Irvin, T. McGovern, 2013 .

Catalase Overexpression Fails to Attenuate Allergic Airways Disease in the Mouse1

E. Wouters, C. Irvin, A. Brown, 2007, The Journal of Immunology.

Exercise Physiology

C. Irvin, K. M. Burkart, C G Irvin, 2003, Springer New York.

Criteria to screen for chronic sinonasal disease.

R. Naclerio, M. Ishii, S. Zinreich, 2009, Chest.

Measuring lung function in mice: the phenotyping uncertainty principle.

Jason H T Bates, Charles G Irvin, J. Bates, 2003, Journal of applied physiology.

Unrestrained video-assisted plethysmography: a noninvasive method for assessment of lung mechanical function in small animals.

J. Bates, C. Irvin, L. Lundblad, 2008, Journal of applied physiology.

A reevaluation of the validity of unrestrained plethysmography in mice.

J. Bates, A. Adler, C. Irvin, 2002, Journal of applied physiology.

Symposium on obesity and asthma - November 2, 2006.

L. Boulet, C. Laprise, M. Vohl, 2007, Canadian respiratory journal.

Oscillation mechanics of the respiratory system.

Ramon Farré, Zoltán Hantos, Jason H T Bates, 2011, Comprehensive Physiology.

Weight Loss Decreases Inherent and Allergic Methacholine Hyperresponsiveness in Mouse Models of Diet-Induced Obese Asthma.

J. Bates, A. Dixon, C. Irvin, 2016, American journal of respiratory cell and molecular biology.

Quality control of peak flow meters for multicenter clinical trials. The Asthma Clinical Research Network (ACRN).

R. Martin, V. Chinchilli, C. Irvin, 1997, American journal of respiratory and critical care medicine.

Effect of Continuous Positive Airway Pressure on Airway Reactivity in Asthma. A Randomized, Sham-controlled Clinical Trial.

E. Sugar, R. Wise, C. Irvin, 2016, Annals of the American Thoracic Society.

The Effect of Flavored E-cigarettes on Murine Allergic Airways Disease

C. Irvin, Y. Janssen-Heininger, J. L. van der Velden, 2019, Scientific Reports.

The requirement for polymorphonuclear leukocytes in the late asthmatic response and heightened airways reactivity in an animal model.

W. Marsh, C. Haslett, G. Larsen, 2015, The American review of respiratory disease.

Obesity and asthma: an inflammatory disease of adipose tissue not the airway.

R. Pratley, A. Dixon, C. Irvin, 2012, American journal of respiratory and critical care medicine.

Asthma Prevalence and Phenotyping in the General Population: The LEAD (Lung, hEart, sociAl, boDy) Study

C. Irvin, C. Schiffers, S. Hartl, 2023, Journal of asthma and allergy.

Knowledge and use of office spirometry for the detection of chronic obstructive pulmonary disease by primary care physicians.

C. Irvin, T. Marcy, D. Kaminsky, 2005, Respiratory care.

Glutathione-S-transferase P promotes glycolysis in asthma in association with oxidation of pyruvate kinase M2

I. Adcock, E. Wouters, C. Wolf, 2021, Redox biology.

Airway and tissue mechanics in a murine model of asthma: alveolar capsule vs. forced oscillations.

J. Bates, C. Irvin, S. Tomioka, 2002, Journal of applied physiology.

Anatomy, pathology, and physiology of the tracheobronchial tree: emphasis on the distal airways.

Q. Hamid, C. Irvin, D. Hyde, 2009, The Journal of allergy and clinical immunology.

Nonlinearity of respiratory mechanics during bronchoconstriction in mice with airway inflammation.

H. T. Moriya, J. Bates, C. Irvin, 2002, Journal of applied physiology.

BMI but not central obesity predisposes to airway closure during bronchoconstriction

J. Bates, R. Wise, A. Dixon, 2019, Respirology.

The synergistic interactions of allergic lung inflammation and intratracheal cationic protein.

J. Bates, C. Irvin, H. Haverkamp, 2008, American journal of respiratory and critical care medicine.

Pyruvate Kinase M2 Promotes Expression of Proinflammatory Mediators in House Dust Mite–Induced Allergic Airways Disease

E. Wouters, A. Dixon, C. Irvin, 2020, The Journal of Immunology.

Nuclear factor-kappaB activation in airway epithelium induces inflammation and hyperresponsiveness.

J. Alcorn, C. Irvin, A. Brown, 2008, American journal of respiratory and critical care medicine.

Biomarkers of type 2 airway inflammation as predictors of loss of asthma control during step-down therapy for well-controlled disease: The Long Acting Beta Agonist Step-down Study (LASST).

M. Castro, S. Peters, C. Bime, 2020, The journal of allergy and clinical immunology. In practice.

Anatomic correlates of reversible restrictive lung disease.

C. Irvin, D. Kaminsky, 1993, Chest.

Clinical characterization of children with resistant airflow obstruction, a multicenter study

L. Bacharier, W. Teague, L. Gerald, 2018, The Journal of asthma : official journal of the Association for the Care of Asthma.

Risk Factors for Montelukast Treatment Failure in Step-Down Therapy for Controlled Asthma

M. Castro, S. Peters, E. Sugar, 2011, The Journal of asthma : official journal of the Association for the Care of Asthma.

Efficacy of nasal mometasone for the treatment of chronic sinonasal disease in patients with inadequately controlled asthma.

M. Castro, S. Peters, L. Gerald, 2015, The Journal of allergy and clinical immunology.

Oscillation mechanics of the human lung periphery in asthma.

Jason H T Bates, Charles G Irvin, H. T. Moriya, 2004, Journal of applied physiology.

controls when supine distinguish mild asthmatic subjects from healthy Heterogeneity of bronchoconstriction does not

J. Bates, R. Pellegrino, C. Salome, 2015 .

Lung volume: a principle determinant of airway smooth muscle function

C. Irvin, 2003, European Respiratory Journal.

Fluctuation Analysis of Peak Expiratory Flow and Its Association with Treatment Failure in Asthma

Lucy Lu Wang, David M. Shade, J. Bates, 2017, American journal of respiratory and critical care medicine.

Chronic Rhinosinusitis and Structural Remodeling.

C. Irvin, 2017, American journal of respiratory cell and molecular biology.

The nonallergic asthma of obesity. A matter of distal lung compliance.

Jason H T Bates, Anne E Dixon, Charles G Irvin, 2014, American journal of respiratory and critical care medicine.

Airway-parenchyma uncoupling in nocturnal asthma.

R. Martin, C. Irvin, J. Pak, 2000, American journal of respiratory and critical care medicine.

Using lung function measurements to greater advantage in patients with lung disease: Which test and when?

C. Irvin, G. Hall, 2014, Respirology.

Polygenic heritability estimates in pharmacogenetics: focus on asthma and related phenotypes

E. Stahl, R. Plenge, M. Ritchie, 2013, Pharmacogenetics and genomics.

The effect of montelukast and low-dose theophylline on cardiovascular disease risk factors in asthmatics.

D. Conti, M. Mehrabian, H. Allayee, 2007, Chest.

The phosphatidylinositide 3-kinase (PI3K) signaling pathway is a determinant of zileuton response in adults with asthma

M. Kubo, A. Dahlin, A. Litonjua, 2018, The Pharmacogenomics Journal.

Strain-dependent activation of NF-kappaB in the airway epithelium and its role in allergic airway inflammation.

J. Alcorn, J. Kolls, C. Irvin, 2010, American journal of physiology. Lung cellular and molecular physiology.

computed tomography in induced bronchospasm Mechanism of mosaic attenuation of the lungs on

D. Hansell, J. Bates, M. Rubens, 2015 .

and responsiveness of immature and mature rabbits Effect of transpulmonary pressure on airway diameter

J. Fredberg, J. Bates, A. Majumdar, 2015 .

New insights from lung function

David A. Kaminsky, C. Irvin, D. Kaminsky, 2001, Current opinion in allergy and clinical immunology.

Race and Ethnicity in Pulmonary Function Test Interpretation: An Official American Thoracic Society Statement.

S. Stanojevic, M. Rosenfeld, N. Thakur, 2023, American journal of respiratory and critical care medicine.

Pathobiology of Human Disease: Asthma

C. Irvin, D. Chapman, M. Dowell, 2014 .

Penh is not a measure of airway resistance!

J. Bates, Z. Hantos, W. Mitzner, 2007, European Respiratory Journal.

Effect of Obesity on Clinical Presentation and Response to Treatment in Asthma

David M. Shade, H. Allayee, D. Shade, 2006, The Journal of asthma : official journal of the Association for the Care of Asthma.

Chapter 5 – Pulmonary Physiology

C. Irvin, 2009 .

Determinants of chronic carbon dioxide retention and its correction in humans.

J. Dempsey, J. Skatrud, C. Irvin, 1980, The Journal of clinical investigation.

Animal Models of Allergic Airways Disease: Where Are We and Where to Next?

C. Irvin, J. Nolin, Y. Janssen-Heininger, 2014, Journal of cellular biochemistry.

The utility of spirometry in the diagnosis of reversible airways obstruction.

H. R. Smith, C. Irvin, R. Cherniack, 1992, Chest.

44 – Development, Structure, and Physiology in Normal Lung and in Asthma

C. Irvin, 2014 .

Detrimental effects of albuterol on airway responsiveness requires airway inflammation and is independent of β-receptor affinity in murine models of asthma

J. Bates, C. Irvin, L. Barone, 2011, Respiratory research.

Validation of the clinical utility of sGaw as a response variable in methacholine challenge testing

C. Irvin, J. Haynes, D. Kaminsky, 2022, Respirology.

Neonatal calves develop airflow limitation due to chronic hypobaric hypoxia.

K. Stenmark, C. Irvin, C. Orton, 1991, Journal of applied physiology.

physiological mechanisms hyperresponsiveness are the result of diverse Intrinsic and antigen-induced airway

R. Price, J. Bates, C. Irvin, 2015 .

Heterogeneity of bronchoconstriction does not distinguish mild asthmatic subjects from healthy controls when supine.

J. Bates, C. Irvin, D. Kaminsky, 2008, Journal of applied physiology.

Circulating MicroRNAs associated with Bronchodilator Response in Childhood Asthma

A. Kho, J. Celedón, S. Peters, 2023, Research square.

Computational assessment of airway wall stiffness in vivo in allergically inflamed mouse models of asthma.

J. Bates, C. Irvin, H. Haverkamp, 2008, Journal of applied physiology.

Exaggerated airway narrowing in mice treated with intratracheal cationic protein.

J. Bates, C. Irvin, S. Wagers, 2006, Journal of applied physiology.

Airway hyperresponsiveness induced by cationic proteins in vivo: site of action.

J. Bates, C. Irvin, T. Homma, 2005, American journal of physiology. Lung cellular and molecular physiology.

An epilogue to lung function and lung disease: State‐of‐the‐art 2015

C. Irvin, G. Hall, 2015, Respirology.

The Madison Avenue effect: how drug presentation style influences adherence and outcome in patients with asthma.

C. Rand, M. Castro, W. Teague, 2011, The Journal of allergy and clinical immunology.

Effect of intranasal corticosteroids on allergic airway disease in asthma.

T. Casale, M. Castro, L. Gerald, 2017, The journal of allergy and clinical immunology. In practice.

No effect of elevated operating lung volumes on airway function during variable workrate exercise in asthmatic humans.

C. Irvin, H. Haverkamp, Adriane Morrison-Taylor, 2016, Journal of applied physiology.

Tumor Necrosis Factor– (cid:1) Overexpression in Lung Disease A Single Cause behind a Complex Phenotype

J. Bates, C. Irvin, M. Poynter, 2005 .

Thoracic Gas Volume Measurements in Paralyzed Mice

J. Bates, C. Irvin, L. Lundblad, 2004, Annals of Biomedical Engineering.

Going to extremes of lung volume.

C. Irvin, L. Whittaker, 2007, Journal of applied physiology.

Collateral ventilation and gas exchange during airway occlusion in the normal human lung.

C. Irvin, D. Kaminsky, 1994, American Journal of Respiratory and Critical Care Medicine.

Lung Volumes

C. Irvin, 1998 .

Physiologic Evaluation of Patients for Pulmonary Rehabilitation

C. Irvin, T. Corbridge, 1993 .

The safety of inactivated influenza vaccine in adults and children with asthma

J. Fish, M. Castro, K. Neuzil, 2001 .

Effects of Obstructive Sleep Apnea and Gastroesophageal Reflux Disease on Asthma Control in Obesity

E. Sugar, J. Richter, J. Lang, 2011, The Journal of asthma : official journal of the Association for the Care of Asthma.

Genome-wide association study of leukotriene modifier response in asthma

M. Kubo, A. Dahlin, A. Litonjua, 2015, The Pharmacogenomics Journal.

Assessing Maximal Exercise Capacity: Peak Work or Peak Oxygen Consumption?

C. Irvin, D. Kaminsky, A. Sadeghi, 2014, Respiratory Care.

THE ROLE OF 5-LIPOXYGENASE PRODUCTS IN A MOUSE MODEL OF ALLERGIC AIRWAY INFLAMMATION

J. Sheller, C. Funk, C. Irvin, 1998 .

Protein The Synergistic Interactions of Allergic Lung Inflammation and Intratracheal Cationic

J. Bates, C. Irvin, S. Verbanck, 1997 .

Development of Allergen-Induced Airway Inflammation in the Absence of T-bet Regulation Is Dependent on IL-171

D. Metzger, S. Gaffen, C. Irvin, 2009, The Journal of Immunology.

Regulation Is Dependent on IL-17 Inflammation in the Absence of T-bet Development of Allergen-Induced Airway

D. Metzger, S. Gaffen, C. Irvin, 2009 .

Ablation of Glutaredoxin-1 Modulates House Dust Mite-Induced Allergic Airways Disease in Mice.

E. Wouters, Y. Ho, A. Dixon, 2016, American journal of respiratory cell and molecular biology.

Effect of a soy isoflavone supplement on lung function and clinical outcomes in patients with poorly controlled asthma: a randomized clinical trial.

E. Sugar, R. Wise, J. Lima, 2015, JAMA.

Anticholinergic Drugs and Asthma

C. Irvin, R. Bethel, 1987 .

Absorption of montelukast is transporter mediated: a common variant of OATP2B1 is associated with reduced plasma concentrations and poor response

J. Lima, C. Irvin, E. Mougey, 2009, Pharmacogenetics and genomics.

Criteria to screen for chronic sinonasal disease.

R. Naclerio, M. Ishii, S. Zinreich, 2009, Chest.

Nuclear factor-kappaB activation in airway epithelium induces inflammation and hyperresponsiveness.

J. Alcorn, C. Irvin, A. Brown, 2008, American journal of respiratory and critical care medicine.

It's much more than just pretty pictures.

G. Downey, C. Irvin, P. Henson, 2010, American journal of respiratory cell and molecular biology.

Development of eosinophilic airway inflammation and airway hyperresponsiveness requires interleukin-5 but not immunoglobulin E or B lymphocytes.

E. Gelfand, J. Schwarze, C. Irvin, 1999, American journal of respiratory cell and molecular biology.

Weight Loss Decreases Inherent and Allergic Methacholine Hyperresponsiveness in Mouse Models of Diet-Induced Obese Asthma.

J. Bates, A. Dixon, C. Irvin, 2016, American journal of respiratory cell and molecular biology.

Using lung function measurements to greater advantage in patients with lung disease: Which test and when?

C. Irvin, G. Hall, 2014, Respirology.

Methacholine Challenge Testing

J. Wanger, R. Martin, C. Irvin, 1997 .

Attenuation of lung fibrosis in mice with a clinically relevant inhibitor of glutathione-S-transferase π.

D. Townsend, K. Tew, C. Wolf, 2016, JCI insight.

Bronchodilator response does not associate with asthma control or symptom burden among patients with poorly controlled asthma.

E. Sugar, R. Wise, A. Dixon, 2023, Respiratory medicine.

Diagnostic accuracy of FEV1/forced vital capacity ratio z scores in asthmatic patients.

M. McCormack, R. Wise, C. Irvin, 2015, The Journal of allergy and clinical immunology.

Airway smooth muscle as a target for asthma therapy.

C. Irvin, J. Solway, 2007, The New England journal of medicine.

European Respiratory Society/American Thoracic Society technical statement: standardisation of the measurement of lung volumes, 2023 update

A. Coates, F. Burgos, K. Sylvester, 2023, European Respiratory Journal.

Obesity and asthma: an inflammatory disease of adipose tissue not the airway.

R. Pratley, A. Dixon, C. Irvin, 2012, American journal of respiratory and critical care medicine.

muscle in an abnormal lung? The allergic mouse model of asthma: normal smooth

C. Irvin, S. Wagers, H. Jason, 2013 .

Interleukin-6 as a biomarker for asthma: hype or is there something else?

C. Irvin, M. Poynter, 2016, European Respiratory Journal.

A polymorphism in the NPPA gene associates with asthma

Jianwei Wang, R. Lockey, Julie A. Johnson, 2008, Clinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology.