D. Huszar

发表

The role of B cells in lpr/lpr-induced autoimmunity

M. Shlomchik, M. Madaio, D. Ni, 1994, The Journal of experimental medicine.

Targeted Disruption of the Melanocortin-4 Receptor Results in Obesity in Mice

R. Cone, R. Kesterson, D. Huszar, 1997, Cell.

Comparisons of the efficacy of a Jak1/2 inhibitor (AZD1480) with a VEGF signaling inhibitor (cediranib) and sham treatments in mouse tumors using DCE-MRI, DW-MRI, and histology.

Thomas E Yankeelov, John C Gore, Mary E Loveless, 2012, Neoplasia.

The JAK2 inhibitor AZD1480 potently blocks Stat3 signaling and oncogenesis in solid tumors.

Hua Yu, Hong Xin, Minwei Ye, 2009, Cancer cell.

Generation of pigmented stripes in albino mice by retroviral marking of neural crest melanoblasts.

R. Jaenisch, A. Sharpe, D. Huszar, 1991, Development.

Migration and proliferation of cultured neural crest cells in W mutant neural crest chimeras.

R. Jaenisch, A. Sharpe, D. Huszar, 1991, Development.

Repair‐deficient 3‐methyladenine DNA glycosylase homozygous mutant mouse cells have increased sensitivity to alkylation‐induced chromosome damage and cell killing.

L. Samson, B. Engelward, D. Huszar, 1996, The EMBO journal.

Induction of neuropeptide Y gene expression in the dorsal medial hypothalamic nucleus in two models of the agouti obesity syndrome.

R. Cone, R. Kesterson, D. Huszar, 1997, Molecular endocrinology.

Response of melanocortin–4 receptor–deficient mice to anorectic and orexigenic peptides

R. Palmiter, R. Laufer, D. Huszar, 1999, Nature Genetics.

Insertion of a bacterial gene into the mouse germ line using an infectious retrovirus vector.

J. Rossant, R. Balling, A. Bernstein, 1985, Proceedings of the National Academy of Sciences of the United States of America.

Antigen-specific human antibodies from mice comprising four distinct genetic modifications

D. Huszar, N. Lonberg, R. Kay, 1994, Nature.

A Phase I study to assess the safety, tolerability, and pharmacokinetics of AZD4877, an intravenous Eg5 inhibitor in patients with advanced solid tumors

R. Herbst, R. Kurzrock, H. Burris, 2011, Cancer Chemotherapy and Pharmacology.

A Phase I trial of the kinesin spindle protein (Eg5) inhibitor AZD4877 in patients with solid and lymphoid malignancies

G. Schwartz, D. Huszar, J. Stephenson, 2013, Investigational New Drugs.

The PIM inhibitor AZD1208 synergizes with ruxolitinib to induce apoptosis of ruxolitinib sensitive and resistant JAK2-V617F-driven cells and inhibit colony formation of primary MPN cells

L. Mazzacurati, G. Reuther, D. Huszar, 2015, Oncotarget.

Kinesin motor proteins as targets for cancer therapy

D. Huszar, R. Herbst, M. Theoclitou, 2009, Cancer and Metastasis Reviews.

Decreased selective uptake of high density lipoprotein cholesteryl esters in apolipoprotein E knock-out mice.

T. Arai, A. Tall, Wengen Chen, 1999, Proceedings of the National Academy of Sciences of the United States of America.

Targeted Deletion of the tub Mouse Obesity Gene Reveals that tubby Is a Loss-of-Function Mutation

H. Stubdal, A. Moriarty, D. Huszar, 2000, Molecular and Cellular Biology.

Increased LDL cholesterol and atherosclerosis in LDL receptor-deficient mice with attenuated expression of scavenger receptor B1.

T. Arai, A. Tall, D. Huszar, 2000, Arteriosclerosis, thrombosis, and vascular biology.

Targeted mutation reveals a central role for SR-BI in hepatic selective uptake of high density lipoprotein cholesterol.

A. Tall, D. Huszar, J. Deeds, 1998, Proceedings of the National Academy of Sciences of the United States of America.

Discovery of (+)-N-(3-aminopropyl)-N-[1-(5-benzyl-3-methyl-4-oxo-[1,2]thiazolo[5,4-d]pyrimidin-6-yl)-2-methylpropyl]-4-methylbenzamide (AZD4877), a kinesin spindle protein inhibitor and potential anticancer agent.

L. Ronco, V. Oza, D. Huszar, 2011, Journal of medicinal chemistry.

Crossing the SJL lambda locus into kappa‐knockout mice reveals a dysfunction of the lambda 1‐containing immunoglobulin receptor in B cell differentiation.

U. Storb, D. Huszar, B. Kurtz, 1994, The EMBO journal.

Hepatic Scavenger Receptor BI Promotes Rapid Clearance of High Density Lipoprotein Free Cholesterol and Its Transport into Bile*

A. Tall, J. Breslow, D. Huszar, 1999, The Journal of Biological Chemistry.

Abstract 4429: Characterization of the kinesin spindle protein inhibitor AZD4877

M. Pinzon-Ortiz, C. Reimer, L. Pablo, 2010 .

Gene-targeted B-deficient mice reveal a critical role for B cells in the CD4 T cell response.

Y. Wu, D. Huszar, Yan Wu, 1995, International immunology.

Gene Transfer with Retrovirus Vectors

J. Dick, A. Bernstein, D. Huszar, 1985 .

MYELOID NEOPLASIA AZD1208, a potent and selective pan-Pim kinase inhibitor, demonstrates ef ﬁ cacy in preclinical models of acute myeloid leukemia

L. Platanias, P. Lyne, R. Stone, 2014 .

Mice deficient in fractalkine are less susceptible to cerebral ischemia-reperfusion injury

D. Huszar, S. Soriano, Hong Zhou, 2002, Journal of Neuroimmunology.

Pim kinase inhibition sensitizes FLT3-ITD acute myeloid leukemia cells to topoisomerase 2 inhibitors through increased DNA damage and oxidative stress

A. Tron, D. Perrotti, R. Trotta, 2016, Oncotarget.

Modulation of gene expression in multiple hematopoietic cell lineages following retroviral vector gene transfer.

J. Dick, A. Bernstein, D. Huszar, 1987, Proceedings of the National Academy of Sciences of the United States of America.

Phase I/II multicenter study to assess the safety, tolerability, pharmacokinetics and pharmacodynamics of AZD4877 in patients with refractory acute myeloid leukemia

M. Minden, G. Curt, H. Kantarjian, 2012, Investigational New Drugs.

Discovery of 5-chloro-N2-[(1S)-1-(5-fluoropyrimidin-2-yl)ethyl]-N4-(5-methyl-1H-pyrazol-3-yl)pyrimidine-2,4-diamine (AZD1480) as a novel inhibitor of the Jak/Stat pathway.

Jon Read, Mei Su, Minwei Ye, 2011, Journal of medicinal chemistry.

Immunoglobulin gene rearrangement in B cell deficient mice generated by targeted deletion of the JH locus.

F. Alt, Jianzhu Chen, F. Young, 1993, International immunology.

Effects of mutations at the W locus (c-kit) on inner ear pigmentation and function in the mouse.

K. Steel, R. Jaenisch, D. Huszar, 1994, Pigment cell research.

Partial purification and characterization of the ribonucleotide reductase induced by herpes simplex virus infection of mammalian cells

S. Bacchetti, D. Huszar, 1981, Journal of virology.

AZD1208, a potent and selective pan-Pim kinase inhibitor, demonstrates efficacy in preclinical models of acute myeloid leukemia.

Allan Wu, Paul D Lyne, Xiaolan Zheng, 2014, Blood.

Immunological characterization of herpes simplex virus type 1 and 2 polypeptide(s) involved in viral ribonucleotide reductase activity

S. Bacchetti, D. Huszar, M. Evelegh, 1984, Journal of virology.

Introduction of a selectable gene into primitive stem cells capable of long-term reconstitution of the hemopoietic system of W/Wv mice

J. Dick, A. Bernstein, D. Huszar, 1985, Cell.

Therapeutic Potential of AZD1480 for the Treatment of Human Glioblastoma

Ying Zheng, D. Huszar, G. Gillespie, 2011, Molecular Cancer Therapeutics.

Preclinical Development Therapeutic Potential of AZD 1480 for the Treatment of Human Glioblastoma

Ying Zheng, D. Huszar, C. Langford, 2011 .

A role for Smad6 in development and homeostasis of the cardiovascular system

M. Gimbrone, J. Lorenz, D. Huszar, 2000, Nature Genetics.

The IL-6/JAK/Stat3 feed-forward loop drives tumorigenesis and metastasis.

Ming Li, Elisa de Stanchina, Claudio Ceccarelli, 2013, Neoplasia.

Phenotypic analysis of mice expressing exclusively apolipoprotein B48 or apolipoprotein B100.

Robert V Farese, S. Young, J. Loring, 1996, Proceedings of the National Academy of Sciences of the United States of America.

Pharmacologic Inhibition of Jak2–Stat5 Signaling By Jak2 Inhibitor AZD1480 Potently Suppresses Growth of Both Primary and Castrate-Resistant Prostate Cancer

B. Leiby, M. Nevalainen, C. Lallas, 2013, Clinical Cancer Research.

High efficiency gene transfer and expression in normal murine B lymphocytes.

J. Dick, A. Bernstein, Dong-Dong Wu, 1987, Journal of immunological methods.

Phenotypic rescue of mutant brown melanocytes by a retrovirus carrying a wild-type tyrosinase-related protein gene.

R. Jaenisch, I. Jackson, P. Laipis, 1990, Development.

Human antibodies from transgenic mice.

D. Huszar, N. Lonberg, N Lonberg, 1995, International reviews of immunology.

B cell development in mice that lack one or both immunoglobulin kappa light chain genes.

F. Alt, F. Young, J. Loring, 1993, The EMBO journal.

The site and stage of anti-DNA B-cell deletion

R. Hardy, M. Radic, S. Camper, 1995, Nature.

Partial inhibition of gp130-Jak-Stat3 signaling prevents Wnt–β-catenin–mediated intestinal tumor growth and regeneration

Chin Wee Tan, R. Jorissen, O. Sieber, 2014, Science Signaling.

Effects of the JAK2 Inhibitor, AZ960, on Pim/BAD/BCL-xL Survival Signaling in the Human JAK2 V617F Cell Line SET-2*

Tao Wang, Minwei Ye, Nancy Su, 2008, Journal of Biological Chemistry.

The IL-6 / JAK / Stat 3 Feed-Forward Loop Drives Tumorigenesis and Metastasis 1 , 2

K. Manova, E. Stanchina, L. Norton, 2013 .

Discovery of 1-methyl-1H-imidazole derivatives as potent Jak2 inhibitors.

Mei Su, Minwei Ye, C. Chuaqui, 2014, Journal of medicinal chemistry.

p63 expression correlates with sensitivity to the Eg5 inhibitor AZD4877 in bladder cancer cells

C. Dinney, D. McConkey, A. Siefker-Radtke, 2012, Cancer biology & therapy.

Concurrent Inhibition of Pim and FLT3 Kinases Enhances Apoptosis of FLT3-ITD Acute Myeloid Leukemia Cells through Increased Mcl-1 Proteasomal Degradation

A. Tron, D. Perrotti, R. Trotta, 2017, Clinical Cancer Research.

JAK2 inhibition sensitizes resistant EGFR-mutant lung adenocarcinoma to tyrosine kinase inhibitors

Robert M. Vogel, M. Ladanyi, W. Pao, 2016, Science Signaling.

JAK 2 inhibition sensitizes resistant EGFR-mutant lung adenocarcinoma to tyrosine kinase inhibitors

Robert M. Vogel, M. Ladanyi, E. Stanchina, 2016 .

The mahogany protein is a receptor involved in suppression of obesity

P. Bork, C. Ebeling, G. Carlson, 1999, Nature.

The resolution of acute malaria in a definitive model of B cell deficiency, the JHD mouse.

D. Huszar, Clive S. Woodhouse, H. C. van der Heyde, 1994, Journal of immunology.

A small-molecule SUMOylation inhibitor activates antitumor immune responses and potentiates immune therapies in preclinical models

Steven S. Langston, Xingyue He, E. Lightcap, 2021, Science Translational Medicine.

Light Chain Editing in K-deficient Animals : A Potential Mechanism of B Cell Tolerance By Eline

D. Huszar, M. Trounstine, Luning Prak, 2003 .

Light chain editing in kappa-deficient animals: a potential mechanism of B cell tolerance

E. L. Prak, M. Weigert, D. Huszar, 1994, The Journal of experimental medicine.

A sumoylation program is essential for maintaining the mitotic fidelity in proliferating mantle cell lymphoma cells

S. Chen‐Kiang, R. Baiocchi, B. Blaser, 2022, Experimental Hematology & Oncology.

The SUMOylation inhibitor subasumstat potentiates rituximab activity by IFN1-dependent macrophage and NK cell stimulation

Kristina Xega, A. Berger, Keli Song, 2022, Blood.

PIM kinase inhibitor AZD1208 for treatment of MYC-driven prostate cancer.

S. Abdulkadir, S. Grosskurth, A. Kirschner, 2015, Journal of the National Cancer Institute.

Next-generation sequencing identifies a novel ELAVL1–TYK2 fusion gene in MOLM-16, an AML cell line highly sensitive to the PIM kinase inhibitor AZD1208

A. Khwaja, A. Tron, D. Linch, 2016, Leukemia & lymphoma.

Antiangiogenic and antimetastatic activity of JAK inhibitor AZD1480.

R. Figlin, Hua Yu, R. Jove, 2011, Cancer research.

Targeted Blockade of JAK/STAT3 Signaling Inhibits Ovarian Carcinoma Growth

Yan Zhou, S. Litwin, E. Nicolas, 2015, Molecular Cancer Therapeutics.

Establishment and chimera analysis of 129/SvEv- and C57BL/6-derived mouse embryonic stem cell lines.

A. Joyner, D. Huszar, W. Auerbach, 2000, BioTechniques.

A Selective and Potent Oral Inhibitor of the JAK2 Tyrosine Kinase Reverses Polycythemia and Leukocytosis Induced by JAK2 V617F in a Mouse Model.

R. A. Etten, R. Chopra, D. Huszar, 2007 .

Differential regulation of mTOR signaling determines sensitivity to AKT inhibition in diffuse large B cell lymphoma

S. Grosskurth, B. Davies, Scott A. Ezell, 2016, Oncotarget.

Therapeutic Inhibition of Jak Activity Inhibits Progression of Gastrointestinal Tumors in Mice

D. Huszar, P. Waring, T. Putoczki, 2014, Molecular Cancer Therapeutics.

Microenvironment and Immunology Antiangiogenic and Antimetastatic Activity of JAK Inhibitor AZD 1480

R. Figlin, Hua Yu, R. Jove, 2011 .

AZD1208, a Novel, Potent and Selective Pan PIM Kinase Inhibitor, Demonstrates Efficacy in Models of Acute Myeloid Leukemia

P. Lyne, Jeffrey L. Brown, E. Keeton, 2011 .

PIM and AKT kinase inhibitors show synergistic cytotoxicity in acute myeloid leukaemia that is associated with convergence on mTOR and MCL1 pathways

A. Khwaja, B. Davies, D. Linch, 2014, British journal of haematology.

Discovery and Optimization of a Novel Series of Highly Selective JAK1 Kinase Inhibitors.

C. Chuaqui, A. Ferguson, P. Lyne, 2018, Journal of medicinal chemistry.

Pharmacologic Suppression of JAK1/2 by JAK1/2 Inhibitor AZD1480 Potently Inhibits IL-6–Induced Experimental Prostate Cancer Metastases Formation

B. Leiby, M. Nevalainen, T. Mirtti, 2014, Molecular Cancer Therapeutics.

Planktonic algae, other than desmids, of three Amazonian systems (Lake Batata, Lake Mussurá and Trombetas River), Pará, Brazil

D. Huszar, V. Lûcia, 1996 .

Human immunoglobulin transgenes undergo rearrangement, somatic mutation and class switching in mice that lack endogenous IgM.

K M Higgins, D. Huszar, Clive S. Woodhouse, 1994, International immunology.

Herpes simplex virus-induced ribonucleotide reductase: development of antibodies specific for the enzyme.

S. Bacchetti, D. Huszar, S. Beharry, 1983, The Journal of general virology.

Is ribonucleotide reductase the transforming function of herpes simplex virus 2?

S. Bacchetti, D. Huszar, 1983, Nature.

Genetic engineering of mouse and human stem cells.

J. Rossant, J. Dick, Z. Estrov, 1986, Cold Spring Harbor symposia on quantitative biology.

Concurrent Inhibition of Pim-1 and FLT3 Kinases in FLT3-ITD Acute Myeloid Leukemia Post-Translationally Downregulates the Anti-Apoptotic Protein Mcl-1 through Downregulation of the Mcl-1 Deubiquitinase USP9X

A. Tron, D. Perrotti, R. Trotta, 2016 .

The role of B cells in lpr/lpr-induced autoimmunity

M. Shlomchik, M. Madaio, D. Huszar, 1994, The Journal of experimental medicine.

PIM and AKT kinase inhibitors show synergistic cytotoxicity in acute myeloid leukaemia that is associated with convergence on mTOR and MCL1 pathways

A. Khwaja, B. Davies, D. Linch, 2014, British journal of haematology.

Trackable Intratumor Microdosing and Spatial Profiling Provide Early Insights into Activity of Investigational Agents in the Intact Tumor Microenvironment

R. Klinghoffer, D. Huszar, P. Swiecicki, 2023, Clinical cancer research : an official journal of the American Association for Cancer Research.