J. Zikherman

发表

Endogenous antigen tunes the responsiveness of naive B cells but not T cells

A. Weiss, J. Zikherman, Ramya Parameswaran, 2012, Nature.

IgM and IgD B cell receptors differentially respond to endogenous antigens and control B cell fate

A. Satterthwaite, L. Garrett-Sinha, F. Brombacher, 2018, eLife.

Control of autoreactive B cells by IgM and IgD B cell receptors: maintaining a fine balance.

J. Zikherman, Mark Noviski, M. Noviski, 2018, Current opinion in immunology.

Optimal Development of Mature B Cells Requires Recognition of Endogenous Antigens

J. Zikherman, Mark Noviski, James L. Mueller, 2019, The Journal of Immunology.

“A negative feedback loop mediated by the NR4A family of nuclear hormone receptors restrains expansion of B cells that receive signal one in the absence of signal two”

A. Marson, J. Zikherman, Mark Noviski, 2020, bioRxiv.

NR4A nuclear receptors restrain B cell responses to antigen when second signals are absent or limiting

A. Marson, J. Zikherman, Mark Noviski, 2020, Nature Immunology.

Self‐reactivity on a spectrum: A sliding scale of peripheral B cell tolerance

J. Zikherman, Mark Noviski, Corey Tan, 2019, Immunological reviews.

CD45-Csk phosphatase-kinase titration uncouples basal and inducible T cell receptor signaling during thymic development.

S. Watson, A. Weiss, C. Goodnow, 2010, Immunity.

Quantitative differences in CD45 expression unmask functions for CD45 in B-cell development, tolerance, and survival

A. Weiss, J. Zikherman, Ramya Parameswaran, 2011, Proceedings of the National Academy of Sciences.

Nur77 Is Upregulated in B-1a Cells by Chronic Self-Antigen Stimulation and Limits Generation of Natural IgM Plasma Cells

J. Zikherman, Mark Noviski, James L. Mueller, 2017, ImmunoHorizons.

Digital Signaling and Hysteresis Characterize Ras Activation in Lymphoid Cells

Jayajit Das, Arup K. Chakraborty, Arthur Weiss, 2009, Cell.

B cell autoimmunity at the extremes

J. Zikherman, C. Lowell, 2017, Nature Immunology.

Protein Kinase Cδ Promotes Transitional B Cell-Negative Selection and Limits Proximal B Cell Receptor Signaling To Enforce Tolerance

A. Weiss, M. Leitges, J. Zikherman, 2014, Molecular and Cellular Biology.

Tolerance B Cell Receptor Signaling To Enforce ProximalCell-Negative Selection and Limits Promotes Transitional B δ Protein Kinase C

A. Weiss, J. Zikherman, J. Roose, 2014 .

Delta-1 negatively regulates the transition from prehypertrophic to hypertrophic chondrocytes during cartilage formation.

J. Zikherman, L. Niswander, R. Crowe, 1999, Development.

Novel tools to dissect the dynamic regulation of TCR signaling by the kinase Csk and the phosphatase CD45.

A. Weiss, J. Zikherman, Y. Tan, 2013, Cold Spring Harbor symposia on quantitative biology.

A new medical therapy for Cushing disease

A. Weiss, J. Zikherman, 2011 .

An extracatalytic function of CD45 in B cells is mediated by CD22

A. Weiss, J. Zikherman, Mark Noviski, 2015, Proceedings of the National Academy of Sciences.

Regulation of layered T cell tolerance mechanisms by the NR4A family is essential to preserve immune homeostasis and suppress autoimmunity

J. Zikherman, James L. Mueller, R. Hiwa, 2021, bioRxiv.

Synthetic liposomal mimics of biological viruses for the study of immune responses to infection and vaccination.

J. Zikherman, James L. Mueller, W. Cheng, 2020, Bioconjugate chemistry.

The Structural Wedge Domain of the Receptor-like Tyrosine Phosphatase CD45 Enforces B Cell Tolerance by Regulating Substrate Specificity

M. Hermiston, A. Weiss, J. Zikherman, 2013, The Journal of Immunology.

Reporters of TCR signaling identify arthritogenic T cells in murine and human autoimmune arthritis

L. Lattanza, A. Weiss, D. Cheng, 2018, Proceedings of the National Academy of Sciences.

Many Achilles’ heels of B and T cell tolerance

R. Pelanda, J. Zikherman, 2022, Immunological reviews.

Long‐Term Corticosteroid‐Sparing Immunosuppression for Cardiac Sarcoidosis

V. Vedantham, J. Moss, M. Scheinman, 2019, Journal of the American Heart Association.

IL-2 Modulates the TCR Signaling Threshold for CD8 but Not CD4 T Cell Proliferation on a Single-Cell Level

A. Weiss, J. Zikherman, James L. Mueller, 2017, The Journal of Immunology.

Quantitative and Temporal Requirements Revealed for Zap-70 Catalytic Activity During T Cell Development

K. Shokat, A. Weiss, D. Cheng, 2014, Nature Immunology.

Cutting Edge: An In Vivo Reporter Reveals Active B Cell Receptor Signaling in the Germinal Center

J. Zikherman, James L. Mueller, M. Matloubian, 2015, The Journal of Immunology.

Establishment of fetomaternal tolerance through glycan-mediated B cell suppression

J. Zikherman, S. Tuomivaara, T. McIntyre, 2022, Nature.

Tonic LAT-HDAC7 Signals Sustain Nur77 and Irf4 Expression to Tune Naive CD4 T Cells.

E. Verdin, D. Erle, J. Zikherman, 2017, Cell reports.

Negative feedback by NUR77/Nr4a1 restrains B cell clonal dominance during early T-dependent immune responses

J. Zikherman, James L. Mueller, R. Hiwa, 2020, bioRxiv.

The role of T cell receptor signaling thresholds in guiding T cell fate decisions.

J. Zikherman, Byron B. Au-Yeung, 2015, Current opinion in immunology.

PTPN22 Deficiency Cooperates with the CD45 E613R Allele to Break Tolerance on a Non-Autoimmune Background1

M. Hermiston, A. Weiss, J. Zikherman, 2009, The Journal of Immunology.

Tonic Signals: Why Do Lymphocytes Bother?

J. Zikherman, J. Roose, D. Myers, 2017, Trends in immunology.

Monovalent and Multivalent Ligation of the B Cell Receptor Exhibit Differential Dependence upon Syk and Src Family Kinases

Jayajit Das, John Kuriyan, Hidde Ploegh, 2013, Science Signaling.

Molecular basis for potent B cell responses to antigen displayed on particles of viral size.

J. Zikherman, James L. Mueller, W. Cheng, 2023, Nature immunology.

Processing of prodynorphin in BRL-3A cells, a rat liver-derived cell line: implications for the specificity of neuropeptide-processing enzymes

L. Devi, J. Zikherman, S. Petanceska, 1993, Molecular and Cellular Endocrinology.

Alternative splicing of CD45: the tip of the iceberg.

A. Weiss, J. Zikherman, 2008, Immunity.

Origin of the sharp boundary that discriminates positive and negative selection of thymocytes

A. Chakraborty, A. Weiss, A. Prasad, 2009, Proceedings of the National Academy of Sciences.

Nur77 Links Chronic Antigen Stimulation to B Cell Tolerance by Restricting the Survival of Self-Reactive B Cells in the Periphery

P. Wilson, J. Zikherman, Mark Noviski, 2019, The Journal of Immunology.

CD45, CD148, and Lyp/Pep: critical phosphatases regulating Src family kinase signaling networks in immune cells

M. Hermiston, J. Zikherman, Jing W. Zhu, 2009, Immunological reviews.

ATP-Competitive Partial Antagonists of IRE1α’s RNase Segregate Outputs of the UPR

R. Ghosh, F. R. Papa, J. Zikherman, 2021, Nature Chemical Biology.

NR4A nuclear receptors in T and B lymphocytes: Gatekeepers of immune tolerance *

J. Zikherman, James L. Mueller, R. Hiwa, 2022, Immunological reviews.

Mechanisms of neutralizing antibody response probed using synthetic virus-like structures

J. Zikherman, W. Cheng, B. Chackerian, 2023, bioRxiv.

Unbiased Modifier Screen Reveals That Signal Strength Determines the Regulatory Role Murine TLR9 Plays in Autoantibody Production

Mark S. Anderson, M. Hermiston, A. Weiss, 2015, The Journal of Immunology.

Molecular basis for potent B cell responses to antigen displayed on particles of viral size

J. Zikherman, James L. Mueller, W. Cheng, 2023, bioRxiv.

Molecular Origin and Functional Consequences of Digital Signaling and Hysteresis During Ras Activation in Lymphocytes

A. Chakraborty, A. Weiss, C. Govern, 2009, Science Signaling.

A sharp T-cell antigen receptor signaling threshold for T-cell proliferation

K. Shokat, A. Weiss, D. Cheng, 2014, Proceedings of the National Academy of Sciences.

Nr4a nuclear receptors: markers and modulators of antigen receptor signaling.

D. Bending, J. Zikherman, 2023, Current opinion in immunology.

NR4A family members regulate T cell tolerance to preserve immune homeostasis and suppress autoimmunity

J. Zikherman, James L. Mueller, R. Hiwa, 2021, JCI insight.

Antigen receptor signaling in the rheumatic diseases

A. Weiss, J. Zikherman, 2009, Arthritis research & therapy.

PTPN 22 Deficiency Cooperates with the CD 45 E 613 R Allele to Break Tolerance on a Non-Autoimmune Background 1

M. Hermiston, A. Weiss, J. Zikherman, 2009 .

Unraveling the functional implications of GWAS: how T cell protein tyrosine phosphatase drives autoimmune disease.

A. Weiss, J. Zikherman, 2011, The Journal of clinical investigation.

Review Antigen receptor signaling in the rheumatic diseases

A. Weiss, J. Zikherman, 2009 .

Interferon gamma constrains type 2 lymphocyte niche boundaries during mixed inflammation.

R. Locksley, J. Zikherman, Hong-Erh Liang, 2022, Immunity.

Validation of a murine proteome-wide phage display library for the identification of autoantibody specificities

Mark S. Anderson, J. Derisi, M. Wilson, 2023, bioRxiv.

Initiation of neutralizing antibody response probed using synthetic virus-like structures

J. Zikherman, W. Cheng, B. Chackerian, 2023, bioRxiv.

The BAFFling persistence of memory B cells

J. Zikherman, J. Brooks, 2020, The Journal of experimental medicine.

Differential impact of the CD45 juxtamembrane wedge on central and peripheral T cell receptor responses

J. Oksenberg, M. Hermiston, A. Weiss, 2009, Proceedings of the National Academy of Sciences.

IgM and IgD B cell receptors differentially respond to endogenous antigens and control B cell fate

A. Satterthwaite, L. Garrett-Sinha, F. Brombacher, 2018, eLife.

CD45, CD148, and Lyp/Pep: critical phosphatases regulating Src family kinase signaling networks in immune cells

M. Hermiston, J. Zikherman, Jing W. Zhu, 2009, Immunological reviews.

Unraveling the functional implications of GWAS: how T cell protein tyrosine phosphatase drives autoimmune disease.

A. Weiss, J. Zikherman, 2011, The Journal of clinical investigation.

Digital Signaling and Hysteresis Characterize Ras Activation in Lymphoid Cells

A. Chakraborty, A. Weiss, C. Govern, 2009, Cell.

This information is current as Production Role Murine TLR 9 Plays in Autoantibody Signal Strength Determines the Regulatory Unbiased Modifier Screen Reveals

Mark S. Anderson, M. Hermiston, A. Weiss, 2015 .

This information is current as Germinal Center Active B Cell Receptor Signaling in the Cutting Edge : An In Vivo Reporter Reveals

J. Zikherman, M. Matloubian, James L. Mueller, 2015 .

Molecular Origin and Functional Consequences of Digital Signaling and Hysteresis during Ras Activation in Lymphocytes Citation Accessed Terms of Use Detailed Terms

C. Govern, J. Zikherman, A. K. Chakraborty, 2022 .