J. Liddle

发表

A selective jumonji H3K27 demethylase inhibitor modulates the proinflammatory macrophage response

Christopher J. Schofield, Cesar Ramirez-Molina, Udo Oppermann, 2012, Nature.

4-Phenyl-7-azaindoles as potent, selective and bioavailable IKK2 inhibitors demonstrating good in vivo efficacy.

P. Bamborough, W. Rumsey, C. Chung, 2012, Bioorganic & medicinal chemistry letters.

A practical drug discovery project at the undergraduate level.

J. Liddle, M. Fray, D. Coe, 2013, Drug discovery today.

Paradoxical Pharmacological Effects of Deoxy-Tetrahydrocannabinol Analogs Lacking High CB1 Receptor Affinity

J. Liddle, G. Griffin, B. Martin, 2002, Pharmacology.

Structure–activity relationships for 1′,1′-dimethylalkyl-Δ 8 -tetrahydrocannabinols

John R. Miller, J. Liddle, B. Thomas, 2003 .

Inhibition of PAD4 activity is sufficient to disrupt mouse and human NET formation

David M. Wilson, G. Drewes, D. Eberhard, 2015, Nature chemical biology.

Retosiban and Epelsiban: Potent and Selective Orally Available Oxytocin Antagonists

J. Liddle, A. D. Borthwick, 2013 .

Evaluation of a crystallographic surrogate for kallikrein 5 in the discovery of novel inhibitors for Netherton syndrome.

A. Hovnanian, J. Liddle, Kathrine J. Smith, 2019, Acta crystallographica. Section F, Structural biology communications.

Structural and mechanistic basis of differentiated inhibitors of the acute pancreatitis target kynurenine-3-monooxygenase

C. Chung, D. Mole, J. Liddle, 2017, Nature Communications.

Targeting the regulatory site of ER aminopeptidase 1 leads to the discovery of a natural product modulator of antigen presentation.

Jonathan M. Lea, J. Liddle, P. Rowland, 2020, Journal of medicinal chemistry.

Use of a novel and highly selective oxytocin receptor antagonist to characterize uterine contractions in the rat.

P. Woollard, D. Brooks, J. Liddle, 2007, American journal of physiology. Regulatory, integrative and comparative physiology.

4-Phenyl-7-azaindoles as potent and selective IKK2 inhibitors.

P. Bamborough, J. Liddle, M. Morse, 2009, Bioorganic & medicinal chemistry letters.

The development of highly potent and selective small molecule correctors of Z α1-antitrypsin misfolding.

J. Irving, Zhengrong Zhu, D. Lomas, 2021, Bioorganic & medicinal chemistry letters.

Structure guided drug design to develop kallikrein 5 inhibitors to treat Netherton syndrome.

A. Hovnanian, J. Liddle, Kathrine J. Smith, 2019, Bioorganic & medicinal chemistry letters.

Kallikrein 5 inhibitors identified through structure based drug design in search for a treatment for Netherton Syndrome.

A. Hovnanian, J. Liddle, Kathrine J. Smith, 2019, Bioorganic & medicinal chemistry letters.

Carbohydrate-derived iminium salt organocatalysts for the asymmetric epoxidation of alkenes

J. Liddle, P. C. Page, M. Elsegood, 2014 .

Bosutinib prevents vascular leakage by reducing focal adhesion turnover and reinforcing junctional integrity

V. V. van Hinsbergh, P. Hordijk, P. Tuinman, 2020, Journal of Cell Science.

Synthesis of enantiomerically pure tertiary 1,2-aminoalcohols by the highly diastereoselective reductive ring opening of oxazolidines

J. Liddle, H. Heaney, P. C. Page, 2007 .

The discovery of potent and selective kynurenine 3-monooxygenase inhibitors for the treatment of acute pancreatitis.

M. Hann, D. Mole, J. Liddle, 2017, Bioorganic & medicinal chemistry letters.

Pyridyl-2,5-diketopiperazines as potent, selective, and orally bioavailable oxytocin antagonists: synthesis, pharmacokinetics, and in vivo potency.

I. E. Smith, P. Woollard, J. Liddle, 2006, Journal of medicinal chemistry.

Design and development of a series of borocycles as selective, covalent kallikrein 5 inhibitors.

A. Hovnanian, J. Liddle, P. Thomas, 2019, Bioorganic & medicinal chemistry letters.

Synthesis and pharmacology of the isomeric methylheptyl-Δ8-tetrahydrocannabinols

J. Liddle, B. Martin, J. Wiley, 1998 .

A potent and selective Kallikrein-5 inhibitor delivers high pharmacological activity in Netherton Syndrome patient skin.

M. Lennon, A. Hovnanian, D. Grillot, 2021, The Journal of investigative dermatology.

Bosutinib prevents vascular leakage by reducing focal adhesion turnover and reinforcing junctional integrity.

V. V. van Hinsbergh, P. Hordijk, P. Tuinman, 2020, Journal of cell science.

A One-pot Aromatic Vicarious Nucleophilic Substitution of Hydrogen/Alkylation Route to Substituted Nitrobenzenes

J. Liddle, N. Lawrence, D. Jackson, 1996 .

The synthesis of benzylphosphine oxides via aromatic vicarious nucleophilic substitution of hydrogen

J. Liddle, N. Lawrence, D. Jackson, 1995 .

Kynurenine–3–monooxygenase inhibition prevents multiple organ failure in rodent models of acute pancreatitis

J. Iredale, S. Howie, J. Hughes, 2015, Nature Medicine.

Organocatalytic aziridine synthesis using F+ salts.

J. Liddle, S. Fairhurst, D. Hughes, 2009, Organic letters.

An Organocatalytic Synthesis of cis‐N‐Alkyl‐ and N‐Arylaziridine Carboxylates

J. Liddle, D. Hughes, S. Bew, 2009 .

The synthesis of benzylphosphine oxides via vicarious nucleophilic substitution and alkenes via VNS–Horner–Wittig reactions

J. Liddle, N. Lawrence, D. Jackson, 2002 .

Efficient synthesis of benzylphosphine oxides and E-stilbenes

J. Liddle, N. Lawrence, D. Jackson, 1994 .

ASYMMETRIC AROMATIC VICARIOUS NUCLEOPHILIC SUBSTITUTION OF HYDROGEN

J. Liddle, N. Lawrence, D. Jackson, 1997 .

Chiral Brønsted Acid‐Catalyzed Asymmetric Synthesis of N‐Aryl‐cis‐aziridine Carboxylate Esters

J. Liddle, D. Hughes, S. Bew, 2017, Angewandte Chemie.

Increased levels of 3-hydroxykynurenine parallel disease severity in human acute pancreatitis

R. Parks, J. Iredale, Xiaozhong Zheng, 2016, Scientific Reports.

Mechanism for antigenic peptide selection by endoplasmic reticulum aminopeptidase 1

J. Liddle, P. Rowland, D. Georgiadis, 2019, Proceedings of the National Academy of Sciences.

Optimisation of a novel series of potent and orally bioavailable azanaphthyridine SYK inhibitors.

David M. Wilson, J. Liddle, D. Lugo, 2016, Bioorganic & medicinal chemistry letters.

Configuration of a High-Content Imaging Platform for Hit Identification and Pharmacological Assessment of JMJD3 Demethylase Enzyme Inhibitors

Melanie Leveridge, Emma Jones, John Liddle, 2012, Journal of biomolecular screening.

The design of orally bioavailable 2, 5‐diketopiperazine oxytocin antagonists: from concept to clinical candidate for premature labor

J. Liddle, A. D. Borthwick, 2011, Medicinal research reviews.

3-(1',1'-Dimethylbutyl)-1-deoxy-delta8-THC and related compounds: synthesis of selective ligands for the CB2 receptor.

S. Yu, J. Liddle, B. Martin, 1999, Bioorganic & medicinal chemistry.

Lead Discovery for Human Kynurenine 3-Monooxygenase by High-Throughput RapidFire Mass Spectrometry

D. Mole, J. Liddle, I. Uings, 2014, Journal of biomolecular screening.

5-aryl-pyrazolo[3,4-b]pyridines: potent inhibitors of glycogen synthase kinase-3 (GSK-3).

M. Saunders, J. Liddle, S. Garland, 2003, Bioorganic & medicinal chemistry letters.

Enantioselective synthesis of 11-hydroxy-(1′S,2′R)-dimethylheptyl-Δ8-THC, a very potent CB1 agonist

J. Liddle, J. Huffman, 2001 .

Development of a Series of Kynurenine 3-Monooxygenase Inhibitors Leading to a Clinical Candidate for the Treatment of Acute Pancreatitis.

Xiaozhong Zheng, D. Mole, D. Clapham, 2017, Journal of medicinal chemistry.

Progress towards the development of anti-inflammatory inhibitors of IKKbeta.

P. Bamborough, W. Rumsey, J. Liddle, 2009, Current Topics in Medicinal Chemistry.

Cell Penetrant Inhibitors of the KDM4 and KDM5 Families of Histone Lysine Demethylases. 1. 3-Amino-4-pyridine Carboxylate Derivatives.

Douglas W. Thomson, David M. Wilson, Melanie V. Leveridge, 2016, Journal of medicinal chemistry.

Discovery of potent and selective Spleen Tyrosine Kinase inhibitors for the topical treatment of inflammatory skin disease.

David M. Wilson, J. Liddle, D. Somers, 2018, Bioorganic & medicinal chemistry letters.

The discovery of GSK221149A: a potent and selective oxytocin antagonist.

Michael J Allen, John Liddle, Fabrizio Nerozzi, 2008, Bioorganic & medicinal chemistry letters.

A three-component coupling process based on vicarious nucleophilic substitution (VNS(AR))-alkylation reactions: an approach to indoprofen and derivatives.

J. Liddle, N. Lawrence, S. Bushell, 2002, The Journal of organic chemistry.

Development of a small molecule that corrects misfolding and increases secretion of Z α1-antitrypsin

J. Irving, Zhengrong Zhu, D. Lomas, 2020, bioRxiv.

Kynurenine monooxygenase regulates inflammation during critical illness and recovery in experimental acute pancreatitis.

Lucile P. A. Neyton, J. Baillie, J. Iredale, 2023, Cell reports.