P. Rowland

发表

A selective jumonji H3K27 demethylase inhibitor modulates the proinflammatory macrophage response

Christopher J. Schofield, Cesar Ramirez-Molina, Udo Oppermann, 2012, Nature.

BACE-1 inhibitors part 3: identification of hydroxy ethylamines (HEAs) with nanomolar potency in cells.

D. Riddell, C. Dingwall, Christopher N. Johnson, 2008, Bioorganic & medicinal chemistry letters.

BACE-1 inhibitors part 1: identification of novel hydroxy ethylamines (HEAs).

D. Riddell, C. Dingwall, J. Mosley, 2008, Bioorganic & medicinal chemistry letters.

BACE-1 inhibitors part 2: identification of hydroxy ethylamines (HEAs) with reduced peptidic character.

D. Riddell, C. Dingwall, J. Mosley, 2008, Bioorganic & medicinal chemistry letters.

Second generation of BACE-1 inhibitors part 3: Towards non hydroxyethylamine transition state mimetics.

C. Dingwall, J. Mosley, P. Rowland, 2009, Bioorganic & medicinal chemistry letters.

Second generation of BACE-1 inhibitors. Part 1: The need for improved pharmacokinetics.

C. Dingwall, J. Mosley, P. Rowland, 2009, Bioorganic & medicinal chemistry letters.

Second generation of BACE-1 inhibitors part 2: Optimisation of the non-prime side substituent.

C. Dingwall, J. Mosley, P. Rowland, 2009, Bioorganic & medicinal chemistry letters.

Crystal Structure of Human Cytochrome P450 2D6*

Frank E. Blaney, Sandeep Modi, F. Blaney, 2005, Journal of Biological Chemistry.

Crystal structures of ASK1‐inhibtor complexes provide a platform for structure‐based drug design

I. Wall, P. Rowland, R. Tanner, 2013, Protein science : a publication of the Protein Society.

Structural and mechanistic basis of differentiated inhibitors of the acute pancreatitis target kynurenine-3-monooxygenase

C. Chung, D. Mole, J. Liddle, 2017, Nature Communications.

Synthesis and evaluation of novel alpha-amino cyclic boronates as inhibitors of HCV NS3 protease.

Z. Ni, P. Rowland, S. Baker, 2010, Bioorganic & medicinal chemistry letters.

Optimization of Orally Bioavailable PI3Kδ Inhibitors and Identification of Vps34 as a key off-target activity.

P. Grandi, Christina Rau, M. Bantscheff, 2019, Journal of medicinal chemistry.

Targeting the regulatory site of ER aminopeptidase 1 leads to the discovery of a natural product modulator of antigen presentation.

Jonathan M. Lea, J. Liddle, P. Rowland, 2020, Journal of medicinal chemistry.

High-Resolution Crystal Structure of Endoplasmic Reticulum Aminopeptidase 1 with Bound Phosphinic Transition-State Analogue Inhibitor

P. Rowland, E. Stratikos, M. Neu, 2019, ACS medicinal chemistry letters.

Investigation of Janus Kinase (JAK) Inhibitors for Lung Delivery and the Importance of Aldehyde Oxidase Metabolism.

Birgit Dümpelfeld, James M. Woolven, S. Teague, 2021, Journal of medicinal chemistry.

The crystal structure of the flavin containing enzyme dihydroorotate dehydrogenase A from Lactococcus lactis.

K. Jensen, S. Larsen, P. Rowland, 1997, Structure.

Design and Development of a Macrocyclic Series Targeting Phosphoinositide 3-Kinase δ.

C. Chung, M. Convery, P. Rowland, 2020, ACS medicinal chemistry letters.

Crystallization and preliminary X-ray studies of membrane-associated Escherichia coli dihydroorotate dehydrogenase.

K. Jensen, S. Larsen, P. Rowland, 2000, Acta Crystallographica Section D: Biological Crystallography.

Purification and characterization of dihydroorotate dehydrogenase a from lactococcus lactis, crystallization and preliminary X‐ray diffraction studies of the enzyme

K. Jensen, S. Larsen, P. Rowland, 1996, Protein science : a publication of the Protein Society.

The discovery of potent and selective kynurenine 3-monooxygenase inhibitors for the treatment of acute pancreatitis.

M. Hann, D. Mole, J. Liddle, 2017, Bioorganic & medicinal chemistry letters.

Kynurenine–3–monooxygenase inhibition prevents multiple organ failure in rodent models of acute pancreatitis

J. Iredale, S. Howie, J. Hughes, 2015, Nature Medicine.

The crystal structure of lactococcus lactis dihydroorotate dehydrogenase A complexed with the enzyme reaction product throws light on its enzymatic function

Sine Larsen, K. Jensen, S. Larsen, 1998, Protein science : a publication of the Protein Society.

N-(3-Cyano-4,5,6,7-tetrahydro-1-benzothien-2-yl)amides as potent, selective, inhibitors of JNK2 and JNK3.

R. Angell, P. Rowland, M. Cichy-Knight, 2007, Bioorganic & medicinal chemistry letters.

Isoxazolopyrimidine-Based Inhibitors of Plasmodium falciparum Dihydroorotate Dehydrogenase with Antimalarial Activity

David M. Shackleford, P. Rathod, John White, 2018, ACS omega.

Evolution of a Novel, Orally Bioavailable Series of PI3Kδ Inhibitors from an Inhaled Lead for the Treatment of Respiratory Disease.

P. Rowland, C. Jamieson, Simon Peace, 2016, Journal of medicinal chemistry.

Optimization of Novel Indazoles as Highly Potent and Selective Inhibitors of Phosphoinositide 3-Kinase δ for the Treatment of Respiratory Disease.

P. Jones, P. Rowland, N. Parr, 2015, Journal of medicinal chemistry.

Preclinical candidate for the treatment of visceral leishmaniasis that acts through proteasome inhibition

Juan A. Bueren-Calabuig, David W. Gray, Frederick R. C. Simeons, 2019, Proceedings of the National Academy of Sciences.

Mechanism for antigenic peptide selection by endoplasmic reticulum aminopeptidase 1

J. Liddle, P. Rowland, D. Georgiadis, 2019, Proceedings of the National Academy of Sciences.

Reducing False Positives through the Application of Fluorescence Lifetime Technology: A Comparative Study Using TYK2 Kinase as a Model System

P. Rowland, P. Craggs, Bhumika Karamshi, 2021, SLAS discovery : advancing life sciences R & D.

Glucose 6-phosphate dehydrogenase mutations causing enzyme deficiency in a model of the tertiary structure of the human enzyme.

T. Vulliamy, L. Luzzatto, P. Rowland, 1996, Blood.

The three-dimensional structure of glucose 6-phosphate dehydrogenase from Leuconostoc mesenteroides refined at 2.0 A resolution.

P. Rowland, A. Basak, S. Gover, 1994, Structure.

Discovery of Potent, Efficient, and Selective Inhibitors of Phosphoinositide 3-Kinase δ through a Deconstruction and Regrowth Approach.

M. Convery, P. Rowland, Simon Peace, 2018, Journal of medicinal chemistry.

Active site of dihydroorotate dehydrogenase A from Lactococcus lactis investigated by chemical modification and mutagenesis.

K. Jensen, S. Larsen, O. Björnberg, 1997, Biochemistry.

Impact of the physical and chemical environment on the molecular structure of Coprinus cinereus peroxidase.

Palle Schneider, Sine Larsen, Pernille Harris, 2002, Acta crystallographica. Section D, Biological crystallography.

Development of a Series of Kynurenine 3-Monooxygenase Inhibitors Leading to a Clinical Candidate for the Treatment of Acute Pancreatitis.

Xiaozhong Zheng, D. Mole, D. Clapham, 2017, Journal of medicinal chemistry.

In Vitro Resistance Selections for Plasmodium falciparum Dihydroorotate Dehydrogenase Inhibitors Give Mutants with Multiple Point Mutations in the Drug-binding Site and Altered Growth

D. Wirth, F. Gamo, L. Ross, 2014, The Journal of Biological Chemistry.

Optimization of Orally Bioavailable PI3K delta Inhibitors and Identification of Vps34 as a Key Selectivity Target.

P. Grandi, Birgit Dümpelfeld, M. Bantscheff, 2020 .

Discovery of GSK251: A Highly Potent, Highly Selective, Orally Bioavailable Inhibitor of PI3Kδ with a Novel Binding Mode.

Michael D. Goldsmith, Douglas W. Thomson, M. Convery, 2021, Journal of medicinal chemistry.

Site‐directed mutagenesis to facilitate X‐ray structural studies of leuconostoc mesenteroides glucose 6‐phosphate dehydrogenase

P. Rowland, A. Basak, S. Gover, 1993, Protein science : a publication of the Protein Society.

Structure of dihydroorotate dehydrogenase B: electron transfer between two flavin groups bridged by an iron-sulphur cluster.

K. Jensen, S. Larsen, P. Rowland, 2000, Structure.

Second generation of hydroxyethylamine BACE-1 inhibitors: optimizing potency and oral bioavailability.

Brian Clarke, Phil Jeffrey, P. Jeffrey, 2008, Journal of medicinal chemistry.

BACE-1 hydroxyethylamine inhibitors using novel edge-to-face interaction with Arg-296.

C. Dingwall, J. Mosley, P. Rowland, 2010, Bioorganic & medicinal chemistry letters.

Bace-1 Inhibitors Using Novel Edge-to-Face Interaction with Arg-296

C. Howes, C. Dingwall, J. Mosley, 2010 .

Structure-Guided Design and Synthesis of a Pyridazinone Series of Trypanosoma cruzi Proteasome Inhibitors.

Peter G. Dodd, Frederick R. C. Simeons, L. Stojanovski, 2023, Journal of medicinal chemistry.

Dopamine receptors in the mouse vas deferens.

P. Rowland, C. Smith, 1989, Archives internationales de pharmacodynamie et de therapie.

Second generation of BACE-1 inhibitors. Part 1: The need for improved pharmacokinetics.

C. Dingwall, J. Mosley, P. Rowland, 2009, Bioorganic & medicinal chemistry letters.