T. Hébert

发表

Dopamine D1 receptor signalling in dyskinetic Parkinsonian rats revealed by fiber photometry using FRET-based biosensors

F. Benaliouad, Jace Jones-Tabah, H. Mohammad, 2020, Scientific reports.

Dopamine modulates the plasticity of mechanosensory responses in Caenorhabditis elegans

D. van der Kooy, W. Schafer, J. Culotti, 2004, The EMBO journal.

Inverse agonist activity of beta-adrenergic antagonists.

P. Chidiac, M. Bouvier, T. Hébert, 1994, Molecular pharmacology.

A comparison of currents carried by HERG, with and without coexpression of MiRP1, and the native rapid delayed rectifier current. Is MiRP1 the missing link?

Stanley Nattel, Ricardo Caballero, S. Nattel, 2002, The Journal of physiology.

The amidated PACAP1-23 fragment is a potent reduced-size neuroprotective agent.

T. Hébert, M. Létourneau, A. Fournier, 2019, Biochimica et biophysica acta. General subjects.

GPCR Signalling Complexes – Synthesis, Assembly, Trafficking and Specificity

R. Jockers, T. Hébert, Ralf Jockers, 2012, Subcellular Biochemistry.

A simple method to detect allostery in GPCR dimers.

T. Hébert, S. Laporte, E. Goupil, 2013, Methods in cell biology.

Discovery of New Allosteric Modulators of the Urotensinergic System through Substitution of the Urotensin II-Related Peptide (URP) Phenylalanine Residue.

T. Hébert, D. Chatenet, É. Billard, 2018, Journal of medicinal chemistry.

Insight into the role of urotensin II‐related peptide tyrosine residue in UT activation

T. Hébert, M. Létourneau, D. Chatenet, 2017, Biochemical pharmacology.

The role of G proteins in assembly and function of Kir3 inwardly rectifying potassium channels

T. Hébert, Peter Zylbergold, Nitya Ramakrishnan, 2010, Channels.

Dopamine D1 receptor signalling in dyskinetic Parkinsonian rats revealed by fiber photometry using FRET-based biosensors

F. Benaliouad, Jace Jones-Tabah, H. Mohammad, 2020, Scientific Reports.

Measuring G protein‐coupled receptor signalling in the brain with resonance energy transfer based biosensors

Jace Jones-Tabah, P. Clarke, T. Hébert, 2017, Current opinion in pharmacology.

Design and construction of conformational biosensors to monitor ion channel activation: A prototype FlAsH/BRET-approach to Kir3 channels.

T. Hébert, G. Piñeyro, D. Robertson, 2016, Methods.

Structural determinants underlying constitutive dimerization of unoccupied human follitropin receptors.

T. Hébert, Xiuyan Feng, D. Segaloff, 2010, Cellular signalling.

Ligand- and Heterodimer-Directed Signaling of the CB1 Cannabinoid Receptor

B. Hudson, T. Hébert, Melanie E. M. Kelly, 2010, Molecular Pharmacology.

Therapeutic Targeting of the General RNA Polymerase II Transcription Machinery

R. Martin, J. Tanny, T. Hébert, 2020, International journal of molecular sciences.

Cycloheximide inhibits follicle-stimulating hormone β subunit transcription by blocking de novo synthesis of the labile activin type II receptor in gonadotrope cells.

Xiaoping Zhou, D. Bernard, T. Hébert, 2013, Cellular signalling.

Design, Synthesis, and Biological Assessment of Biased Allosteric Modulation of the Urotensin II Receptor Using Achiral 1,3,4-Benzotriazepin-2-one Turn Mimics.

T. Hébert, W. Lubell, D. Chatenet, 2017, Journal of medicinal chemistry.

Hypoxia in early life is associated with lasting changes in left ventricular structure and function at maturity in the rat.

S. Nattel, C. Rohlicek, T. Hébert, 2012, International journal of cardiology.

G Protein-Coupled Receptors in and on the Cell Nucleus: A New Signaling Paradigm?

T. Hébert, B. Boivin, B. Allen, 2008, Journal of receptor and signal transduction research.

Heterodimerization of β1- and β2-Adrenergic Receptor Subtypes Optimizes β-Adrenergic Modulation of Cardiac Contractility

E. Lakatta, Heping Cheng, Dongmei Yang, 2005 .

GPCR Retreat 2012: timing is everything

P. Chidiac, T. Hébert, T. Hébert, 2013, Journal of receptor and signal transduction research.

VCP/p97 regulates β2AR quality control during receptor biosynthesis.

T. Hébert, N. Audet, D. Pétrin, 2017, Cellular signalling.

The functional size of GPCRs - monomers, dimers or tetramers?

T. Hébert, D. Pétrin, T. Hébert, 2012, Sub-cellular biochemistry.

Trafficking-deficient long QT syndrome mutation KCNQ1-T587M confers severe clinical phenotype by impairment of KCNH2 membrane localization: evidence for clinically significant IKr-IKs alpha-subunit interaction.

S. Hohnloser, S. Nattel, R. Brandes, 2009, Heart rhythm.

KvLQT1 Modulates the Distribution and Biophysical Properties of HERG

S. Nattel, T. Hébert, J. Ehrlich, 2004, Journal of Biological Chemistry.

Regulation of cardiac nitric oxide signaling by nuclear β-adrenergic and endothelin receptors.

S. Nattel, T. Hébert, A. Fournier, 2013, Journal of molecular and cellular cardiology.

Gβγ subunits-Different spaces, different faces.

Shahriar M. Khan, T. Hébert, J. Y. Sung, 2016, Pharmacological research.

Bone morphogenetic protein 2 stimulates noncanonical SMAD2/3 signaling via the BMP type 1A receptor in gonadotrope-like cells: implications for FSH synthesis.

Eunjin Bang, D. Bernard, T. Hébert, 2014, Endocrinology.

GABA-B1 Receptors are Coupled to the ERK1/2 MAP Kinase Pathway in the Absence of GABA-B2 Subunits

T. Hébert, M. Richer, L. Villeneuve, 2009, Journal of Molecular Neuroscience.

Intracellular Potassium Stabilizes Human Ether-à-go-go-Related Gene Channels for Export from Endoplasmic Reticulum

T. Hébert, X. Wan, E. Ficker, 2009, Molecular Pharmacology.

Dopamine Receptor-interacting Protein 78 Acts as a Molecular Chaperone for Gγ Subunits before Assembly with Gβ*

M. Robitaille, T. Hébert, M. Richer, 2007, Journal of Biological Chemistry.

Signalosome Profiling Reveals Allosteric Interactions Between G Protein-Coupled Receptors

D. Devost, T. Hébert, D. Pétrin, 2014 .

Gbetagamma subunit combinations differentially modulate receptor and effector coupling in vivo.

T. Hébert, L. Robillard, N. Éthier, 2000, Cellular signalling.

Gβγ subunit combinations differentially modulate receptor and effector coupling in vivo

T. Hébert, L. Robillard, N. Éthier, 2000 .

Seven Transmembrane Receptor Core Signaling Complexes Are Assembled Prior to Plasma Membrane Trafficking*

M. Robitaille, T. Hébert, D. Dupré, 2006, Journal of Biological Chemistry.

Receptor- and cellular compartment-specific activation of the cAMP/PKA pathway by α1-adrenergic and ETA endothelin receptors.

A. Inoue, R. Martin, J. Tanny, 2018, Cellular signalling.

Organellar Gβγ signaling—GPCR signaling beyond the cell surface

R. Martin, T. Hébert, Celia Bouazza, 2020 .

Coexpression of full-length gamma-aminobutyric acid(B) (GABA(B)) receptors with truncated receptors and metabotropic glutamate receptor 4 supports the GABA(B) heterodimer as the functional receptor.

L. F. Kolakowski, G. O'neill, M. Abramovitz, 2000, The Journal of pharmacology and experimental therapeutics.

The MAP kinase ERK5/MAPK7 is a downstream effector of oxytocin signaling in myometrial cells.

D. Devost, H. Zingg, T. Hébert, 2021, Cellular signalling.

Effects of resveratrol treatment on cardiac remodeling following myocardial infarction

S. Nattel, J. Tardif, A. Maguy, 2007 .

Subtypes Optimizes -Adrenergic Modulation of Cardiac Contractility

E. Lakatta, Heping Cheng, Dongmei Yang, 2005 .

neurotransmission in rats Effects of 5-day hypoxia on cardiac adrenergic

P. Merlet, C. Rohlicek, T. Hébert, 2015 .

Targeting the prostaglandin F2α receptor for preventing preterm labor with azapeptide tocolytics.

X. Hou, T. Hébert, S. Laporte, 2011, Journal of medicinal chemistry.

Real-time monitoring of receptor and G-protein interactions in living cells

Michel Bouvier, Céline Galés, M. Bouvier, 2005, Nature Methods.

Real-time BRET assays to measure G protein/effector interactions.

M. Robitaille, T. Hébert, D. Pétrin, 2011, Methods in molecular biology.

Signalling complexes associated with adenylyl cyclase II are assembled during their biosynthesis.

T. Hébert, A. Baragli, D. Dupré, 2007, Cellular signalling.

RGS2 interacts with Gs and adenylyl cyclase in living cells.

P. Chidiac, J. Hepler, T. Hébert, 2006, Cellular signalling.

Interactions between GABA-B1 receptors and Kir 3 inwardly rectifying potassium channels.

T. Hébert, M. Richer, D. Dupré, 2006, Cellular signalling.

Bioluminescence Resonance Energy Transfer Studies Reveal Constitutive Dimerization of the Human Lutropin Receptor and a Lack of Correlation between Receptor Activation and the Propensity for Dimerization*

T. Hébert, Xiuyan Feng, D. Segaloff, 2009, Journal of Biological Chemistry.

Functional rescue of a constitutively desensitized beta2AR through receptor dimerization.

M. Bouvier, T. Hébert, Stéphane, 1998, The Biochemical journal.

Tracking GPCR biosynthesis and degradation using a nonradioactive pulse chase methodology.

D. Devost, T. Hébert, Richard Wargachuk, 2016, Methods in cell biology.

Nuclear G Protein Signaling: New Tricks for Old Dogs

T. Hébert, N. Audet, Rhiannon I. Campden, 2015, Journal of cardiovascular pharmacology.

Signal profiling of the β1AR reveals coupling to novel signalling pathways and distinct phenotypic responses mediated by β1AR and β2AR

D. Devost, J. Aoki, A. Inoue, 2020, Scientific Reports.

Nucleoligands-repurposing G Protein-coupled Receptor Ligands to Modulate Nuclear-localized G Protein-coupled Receptors in the Cardiovascular System.

T. Hébert, N. Audet, B. Allen, 2017, Journal of cardiovascular pharmacology.

Biasing the odds: Approaches to capturing, understanding and exploiting functional selectivity in GPCRs.

T. Hébert, 2016, Methods.

BRET‐based assay to monitor EGFR transactivation by the AT1R reveals Gq/11 protein‐independent activation and AT1R‐EGFR complexes

D. Devost, W. Thomas, A. Inoue, 2018, Biochemical pharmacology.

GPCR heterodimers: asymmetries in ligand binding and signalling output offer new targets for drug discovery

T. Hébert, S. Laporte, E. Goupil, 2013, British journal of pharmacology.

Dynamic regulation of G-protein coupled receptor palmitoylation: potential role in receptor function.

M. Bouvier, T. Hébert, T. Loisel, 1995, Biochemical Society transactions.

Advances from the GPCR Retreat

P. Chidiac, T. Hébert, T. Hébert, 2008 .

Meeting Review: Advances from the GPCR Retreat

P. Chidiac, T. Hébert, T. Hébert, 2008 .

CrossTalk proposal: Weighing the evidence for Class A GPCR dimers, the evidence favours dimers

M. Bouvier, T. Hébert, T. Hébert, 2014, The Journal of physiology.

A Single Conserved Leucine Residue on the First Intracellular Loop Regulates ER Export of G Protein‐Coupled Receptors

M. Robitaille, Guangyu Wu, T. Hébert, 2009, Traffic.

Effective use of genetically-encoded optical biosensors for profiling signalling signatures in iPSC-CMs derived from idiopathic dilated cardiomyopathy patients

N. Giannetti, Jace Jones-Tabah, T. Hébert, 2022, bioRxiv.

Physical and functional interaction between CB1 cannabinoid receptors and β2‐adrenoceptors

B. Hudson, T. Hébert, M. Kelly, 2010, British journal of pharmacology.

Histone H2B Ubiquitylation Regulates Histone Gene Expression by Suppressing Antisense Transcription in Fission Yeast

J. Tanny, T. Hébert, K. Ekwall, 2019, Genetics.

Adrenergic control of a constitutively active acetylcholine-regulated potassium current in canine atrial cardiomyocytes.

S. Nattel, Y. Yeh, T. Hébert, 2007, Cardiovascular research.

Effective use of genetically-encoded optical biosensors for profiling signalling signatures in iPSC-CMs derived from idiopathic dilated cardiomyopathy patients

N. Giannetti, Jace Jones-Tabah, T. Hébert, 2022, bioRxiv.

hERG K+ Channel Binding Assays for Cardiac Safety Screening

T. Hébert, J. Guimond, L. Beaudet, 2006 .

Dual allosteric modulation of opioid antinociceptive potency by α2A-adrenoceptors

M. Millecamps, L. Diatchenko, D. Devost, 2015, Neuropharmacology.

hERG Binding Assays for the Identification of Potentially Cardiotoxic Compounds

T. Hébert, N. Bouchard, J. Guimond, 2005 .

Propranolol Attenuates Proangiogenic Activity of Mononuclear Phagocytes: Implication in Choroidal Neovascularization.

Wyston C Pierre, S. Omri, T. Hébert, 2019, Investigative ophthalmology & visual science.

Comparing the signaling and transcriptome profiling landscapes of human iPSC-derived and primary rat neonatal cardiomyocytes

Jace Jones-Tabah, J. Tanny, T. Hébert, 2022, bioRxiv.

Anti-beta1AR antibodies in dilated cardiomyopathy: are these a new class of receptor agonists?

T. Hébert, 2007, Cardiovascular research.

Activation-induced subcellular redistribution of G alpha(s) is dependent upon its unique N-terminus.

D. Evanko, H. V. Van Tol, T. Hébert, 2002, Biochemistry.

Beta 1/beta 2-adrenergic receptor heterodimerization regulates beta 2-adrenergic receptor internalization and ERK signaling efficacy.

E. Lakatta, J. Mercier, M. Bouvier, 2002, The Journal of biological chemistry.

Dynamic palmitoylation of G-protein-coupled receptors in eukaryotic cells.

B. Mouillac, P. Chidiac, M. Bouvier, 1995, Methods in enzymology.

Rab1 GTPase and Dimerization in the Cell Surface Expression of Angiotensin II Type 2 Receptor

M. Robitaille, Guangyu Wu, T. Hébert, 2009, Journal of Pharmacology and Experimental Therapeutics.

Gbetagamma is a negative regulator of AP-1 mediated transcription.

M. Robitaille, D. Bernard, T. Hébert, 2010, Cellular signalling.

Heterodimerization of beta1- and beta2-adrenergic receptor subtypes optimizes beta-adrenergic modulation of cardiac contractility.

E. Lakatta, Heping Cheng, Dongmei Yang, 2005, Circulation research.

Functional interactions between the oxytocin receptor and the β2-adrenergic receptor: implications for ERK1/2 activation in human myometrial cells.

H. Zingg, T. Hébert, S. Laporte, 2012, Cellular signalling.

A Peptide Derived from a β2-Adrenergic Receptor Transmembrane Domain Inhibits Both Receptor Dimerization and Activation*

Michel Bouvier, D. Bichet, M. Bouvier, 1996, The Journal of Biological Chemistry.

A division of labor: asymmetric roles for GPCR subunits in receptor dimers.

T. Hébert, Peter Zylbergold, T. Hébert, 2009, Nature chemical biology.

Palmitoylation of G-protein-coupled receptors: a dynamic modification with functional consequences.

B. Mouillac, P. Chidiac, M. Bouvier, 1995, Biochemical Society transactions.

A cell surface inactive mutant of the human lutropin receptor (hLHR) attenuates signaling of wild-type or constitutively active receptors via heterodimerization.

T. Hébert, Xiuyan Feng, D. Segaloff, 2009, Cellular signalling.

G protein-coupled receptors in and on the cell nucleus: a new signaling paradigm?

T. Hébert, B. Boivin, B. Allen, 2008, Journal of receptor and signal transduction research.

Gamma-aminobutyric acid type B receptors with specific heterodimer composition and postsynaptic actions in hippocampal neurons are targets of anticonvulsant gabapentin action.

J. Lacaille, R. Mckernan, G. O'neill, 2001, Molecular pharmacology.

Nuclear GPCRs in cardiomyocytes: an insider's view of β-adrenergic receptor signaling.

T. Hébert, B. Allen, G. Vaniotis, 2011, American journal of physiology. Heart and circulatory physiology.

Determinants Present in the Receptor Carboxy Tail Are Responsible for Differences in Subtype-Specific Coupling of β-Adrenergic Receptors to Phosphoinositide 3-Kinase

G. Rousseau, T. Hébert, M. Boucher, 2009, International journal of cell biology.

Pharmacological characterization of putative beta1-beta2-adrenergic receptor heterodimers.

T. Hébert, C. Lavoie, T. Hébert, 2003, Canadian journal of physiology and pharmacology.

β1/β2-Adrenergic Receptor Heterodimerization Regulates β2-Adrenergic Receptor Internalization and ERK Signaling Efficacy*

E. Lakatta, J. Mercier, M. Bouvier, 2002, The Journal of Biological Chemistry.

Adrenoceptors (version 2019.4) in the IUPHAR/BPS Guide to Pharmacology Database

R. Graham, D. Bylund, K. Minneman, 2019, IUPHAR/BPS Guide to Pharmacology CITE.

Protein complexes involved in heptahelical receptor-mediated signal transduction.

T. Hébert, R. V. Rebois, T. Hébert, 2003, Receptors & channels.

Structural and functional aspects of G protein-coupled receptor oligomerization.

M. Bouvier, T. Hébert, T E Hébert, 1998, Biochemistry and cell biology = Biochimie et biologie cellulaire.

Functional Selectivity Revealed by N-Methylation Scanning of Human Urotensin II and Related Peptides.

E. Novellino, P. Grieco, D. Brancaccio, 2019, Journal of medicinal chemistry.

Effects of neonatal hypoxia in the rat on inotropic stimulation of the adult heart.

C. Rohlicek, T. Hébert, S. Viau, 2005, Cardiovascular research.

Gβ4γ1 as a modulator of M3 muscarinic receptor signalling and novel roles of Gβ1 subunits in the modulation of cellular signalling.

Shahriar M. Khan, Ashley M. Jacobi, S. Angers, 2015, Cellular signalling.

IBD-associated G protein-coupled receptor 65 variant compromises signalling and impairs key functions involved in inflammation.

J. Rioux, A. Bitton, P. Goyette, 2022, Cellular signalling.

Measuring hypertrophy in neonatal rat primary cardiomyocytes and human iPSC-derived cardiomyocytes.

Jace Jones-Tabah, T. Hébert, D. Pétrin, 2021, Methods.

Insertion mutations of the RIIA Na+ channel reveal novel features of voltage gating and protein kinase A modulation

P. Drapeau, J. Stone, T. Hébert, 1994, Pflügers Archiv.

Voltage dependencies of the fast and slow gating modes of RIIA sodium channels

P. Drapeau, T. Hébert, R. Monette, 1994, Proceedings of the Royal Society of London. Series B: Biological Sciences.

Co-expression of human Kir3 subunits can yield channels with different functional properties.

H. V. Van Tol, J. Wilson, T. Hébert, 1999, Cellular signalling.

Drug Discovery in Induced Pluripotent Stem Cell Models

Jace Jones-Tabah, T. Hébert, Nourhen Mnasri, 2021, Reference Module in Biomedical Sciences.

Combining Optical Approaches with Human Inducible Pluripotent Stem Cells in G Protein-Coupled Receptor Drug Screening and Development

Jace Jones-Tabah, T. Hébert, Nourhen Mnasri, 2018, Biomolecules.

Dopamine D2 Receptor-Mediated Heterologous Sensitization of AC5 Requires Signalosome Assembly

C. Dessauer, T. Hébert, V. Watts, 2012, Journal of signal transduction.

The Expanding Roles of Gβγ Subunits in G Protein–Coupled Receptor Signaling and Drug Action

Shahriar M. Khan, J. Labbé, T. Hébert, 2013, Pharmacological Reviews.

G protein‐coupled receptor signalling in the cardiac nuclear membrane: evidence and possible roles in physiological and pathophysiological function

S. Nattel, T. Hébert, A. Tadevosyan, 2012, The Journal of physiology.

Design and biological assessment of membrane-tethering neuroprotective peptides derived from the pituitary adenylate cyclase-activating polypeptide type 1 receptor.

D. Devost, T. Hébert, M. Létourneau, 2019, Biochimica et biophysica acta. General subjects.

Nuclear G-Protein Coupled Receptors

T. Hébert, B. Allen, T. Hébert, 2015, Methods in Molecular Biology.

Organizational complexity of β-adrenergic receptor signaling systems.

T. Hébert, Irina Glazkova, K. Altosaar, 2011, Current topics in membranes.

Nuclear β-adrenergic receptors modulate gene expression in adult rat heart.

C. Rohlicek, T. Hébert, B. Allen, 2011, Cellular signalling.

Biosynthesis and trafficking of seven transmembrane receptor signalling complexes.

T. Hébert, D. Dupré, T. Hébert, 2006, Cellular signalling.

Functional beta-adrenergic receptor signalling on nuclear membranes in adult rat and mouse ventricular cardiomyocytes.

T. Hébert, A. Baragli, L. Villeneuve, 2006, Cardiovascular research.

The targetable G protein proteome: where is the next generation of drug targets?

Bruce G. Allen, T. Hébert, R. Victor Rebois, 2004 .

Addition of a carboxy-terminal tail to the normally tailless gonadotropin-releasing hormone receptor impairs fertility in female mice

D. Boerboom, D. Devost, D. Bernard, 2021, eLife.

Addition of a carboxy terminal tail to the normally tailless gonadotropin-releasing hormone receptor impairs fertility in female mice

D. Boerboom, D. Devost, D. Bernard, 2021, bioRxiv.

Subtype-dependent regulation of Gβγ signalling.

T. Hébert, Dinesh Kankanamge, A. Karunarathne, 2021, Cellular signalling.

Signal Transduction Mediated by Heptahelical Receptors and Heterotrimeric G Proteins

T. Hébert, J. Northup, R. V. Rebois, 2006 .

Regulation of GPCR expression through an interaction with CCT7, a subunit of the CCT/TRiC complex

T. Hébert, J. Parent, S. Génier, 2016, Molecular biology of the cell.

High-Content Single-Cell Förster Resonance Energy Transfer Imaging of Cultured Striatal Neurons Reveals Novel Cross-Talk in the Regulation of Nuclear Signaling by Protein Kinase A and Extracellular Signal-Regulated Kinase 1/2

Jace Jones-Tabah, J. Tanny, P. Clarke, 2021, Molecular Pharmacology.

Single cell analysis of population-wide nuclear and cytosolic drug responses using high-content FRET imaging: measuring protein kinase activation in rat primary striatal neurons

Jace Jones-Tabah, J. Tanny, P. Clarke, 2021 .

Functional selectivity in GPCR signaling: understanding the full spectrum of receptor conformations.

T. Hébert, S. Laporte, E. Goupil, 2012, Mini reviews in medicinal chemistry.

The role of Gbetagamma subunits in the organization, assembly, and function of GPCR signaling complexes.

M. Robitaille, T. Hébert, D. Dupré, 2009, Annual review of pharmacology and toxicology.

The Role of G βγ Subunits in the Organization, Assembly, and Function of GPCR Signaling Complexes

M. Robitaille, T. Hébert, D. Dupré, 2009 .

Differential Activation of P-TEFb Complexes in the Development of Cardiomyocyte Hypertrophy following Activation of Distinct G Protein-Coupled Receptors

J. Tanny, T. Hébert, Viviane Pagé, 2020, Molecular and Cellular Biology.

Spt5 C-terminal repeat domain phosphorylation and length negatively regulate heterochromatin through distinct mechanisms

J. Tanny, T. Hébert, Viviane Pagé, 2022, bioRxiv.

Differential Activation of P-TEFb Complexes in the Development of Cardiomyocyte Hypertrophy following Activation of Distinct G Protein-Coupled Receptors

J. Tanny, T. Hébert, Viviane Pagé, 2020, Molecular and Cellular Biology.

A role for BET proteins in regulating basal and dopamine-induced, cAMP/PKA dependent transcription in rat striatal neurons.

Jace Jones-Tabah, J. Tanny, P. Clarke, 2021, Cellular signalling.

Dopamine D1 receptor activation and cAMP/PKA signalling mediate Brd4 recruitment to chromatin to regulate gene expression in rat striatal neurons

Jace Jones-Tabah, J. Tanny, P. Clarke, 2021, bioRxiv.

Characterization of a hyperpolarization‐activated time‐dependent potassium current in canine cardiomyocytes from pulmonary vein myocardial sleeves and left atrium

Stanley Nattel, Liming Zhang, S. Nattel, 2004, The Journal of physiology.

Dihydropyridine and beta adrenergic receptor binding in dogs with tachycardia-induced atrial fibrillation.

S. Nattel, T. Hébert, M. Levi, 1999, Cardiovascular research.

Conformational Dynamics of Kir3.1/Kir3.2 Channel Activation Via δ-Opioid Receptors

G. Balboni, M. Bouvier, Mélissa Richard-Lalonde, 2013, Molecular Pharmacology.

Allosteric interactions between the oxytocin receptor and the β2-adrenergic receptor in the modulation of ERK1/2 activation are mediated by heterodimerization.

D. Devost, H. Zingg, T. Hébert, 2012, Cellular signalling.

Systemic arterial pressure at maturity in rats following chronic hypoxia in early life.

C. Rohlicek, T. Hébert, D. Rodaros, 2010, American journal of hypertension.

Novel, gel-free proteomics approach identifies RNF5 and JAMP as modulators of GPCR stability.

S. Angers, M. Robitaille, T. Hébert, 2013, Molecular endocrinology.

G protein-coupled receptor-effector macromolecular membrane assemblies (GEMMAs).

L. Pardo, F. Ciruela, C. Dessauer, 2021, Pharmacology & therapeutics.

Involvement of lipid rafts and caveolae in cardiac ion channel function.

Stanley Nattel, Ange Maguy, S. Nattel, 2006, Cardiovascular research.

Block of the rat brain IIA sodium channel alpha subunit by the neuroprotective drug riluzole.

R J Dunn, P. Drapeau, T. Hébert, 1994, Molecular pharmacology.

Activins bind and signal via bone morphogenetic protein receptor type II (BMPR2) in immortalized gonadotrope-like cells.

D. Bernard, T. Hébert, Carlis A Rejon, 2013, Cellular signalling.

Biosensor-based profiling to track cellular signalling in patient-derived models of dilated cardiomyopathy.

T. Hébert, Kyla Bourque, Cara Hawey, 2022, Cellular signalling.

Exploring functional consequences of GPCR oligomerization requires a different lens.

D. Devost, Jace Jones-Tabah, P. Clarke, 2020, Progress in molecular biology and translational science.

Heterodimers of adenylyl cyclases 2 and 5 show enhanced functional responses in the presence of Galpha s.

T. Hébert, A. Baragli, L. Villeneuve, 2008, Cellular signalling.

The Signaling and Pharmacology of the Dopamine D1 Receptor

Jace Jones-Tabah, H. Mohammad, P. Clarke, 2022, Frontiers in Cellular Neuroscience.

Tools for drug discovery and disease modeling- the future is upon us.

Jace Jones-Tabah, T. Hébert, Kyla Bourque, 2022, Methods.

The Dynamics of GPCR Oligomerization and Their Functional Consequences.

T. Hébert, Rory Sleno, T. Hébert, 2018, International review of cell and molecular biology.

Stable association of G proteins with beta 2AR is independent of the state of receptor activation.

G. Wolbring, T. Hébert, P. Schnetkamp, 1999, Cellular signalling.

D2-like dopamine and β-adrenergic receptors form a signaling complex that integrates Gs- and Gi-mediated regulation of adenylyl cyclase.

T. Hébert, P. Fishman, J. Northup, 2012, Cellular signalling.

Identification of a GABAB Receptor Subunit, gb2, Required for Functional GABAB Receptor Activity*

Jilly F. Evans, L. F. Kolakowski, T. Bonner, 1999, The Journal of Biological Chemistry.

Conformational Profiling of the AT1 Angiotensin II Receptor Reflects Biased Agonism, G Protein Coupling, and Cellular Context*

D. Devost, J. Aoki, A. Inoue, 2017, The Journal of Biological Chemistry.

Distinct Conformational Dynamics of Three G Protein-Coupled Receptors Measured Using FlAsH-BRET Biosensors

D. Devost, T. Hébert, Rory Sleno, 2017, Front. Endocrinol..

Cardiac-directed overexpression of wild-type alpha1B-adrenergic receptor induces dilated cardiomyopathy.

A. Ducharme, J. Tardif, H. Rindt, 2001, American journal of physiology. Heart and circulatory physiology.

Cardiac-specific Overexpression of a 1BAR Regulates AR Activity Via Molecular Crosstalk

H. Rindt, T. Hébert, B. Allen, 1998 .

Cardiac-specific overexpression of alpha1BAR regulates betaAR activity via molecular crosstalk.

H. Rindt, T. Hébert, B. Allen, 1998, Journal of molecular and cellular cardiology.

PPIP5K1 interacts with the exocyst complex through a C-terminal intrinsically disordered domain and regulates cell motility.

T. Hébert, D. Pétrin, G. J. Miller, 2016, Cellular signalling.

Tandem affinity purification to identify cytosolic and nuclear gβγ-interacting proteins.

S. Angers, M. Robitaille, T. Hébert, 2015, Methods in molecular biology.

A Novel Biased Allosteric Compound Inhibitor of Parturition Selectively Impedes the Prostaglandin F2α-mediated Rho/ROCK Signaling Pathway*

D. Devost, H. Zingg, M. Bouvier, 2010, The Journal of Biological Chemistry.

Intradialytic clearance of opioids: Methadone versus hydromorphone

L. Joseph, T. Hébert, M. Ware, 2013, PAIN®.

Agonist stimulation increases the turnover rate of beta 2AR-bound palmitate and promotes receptor depalmitoylation.

M. Bouvier, T. Hébert, T. Loisel, 1996, Biochemistry.

Intracellular trafficking and assembly of specific Kir3 channel/G protein complexes.

M. Robitaille, T. Hébert, A. Baragli, 2009, Cellular signalling.

Association of neonatal hypoxia with lasting changes in left ventricular gene expression: an animal model.

S. Nattel, C. Rohlicek, C. Tchervenkov, 2009, The Journal of thoracic and cardiovascular surgery.

Activin A regulates porcine follicle-stimulating hormone beta-subunit transcription via cooperative actions of SMADs and FOXL2.

P. Lamba, D. Bernard, T. Hébert, 2010, Endocrinology.

Imaging-based approaches to understanding g protein-coupled receptor signalling complexes.

T. Hébert, D. Pétrin, T. Hébert, 2011, Methods in molecular biology.

Combining protein complementation assays with resonance energy transfer to detect multipartner protein complexes in living cells.

M. Robitaille, T. Hébert, Peter Zylbergold, 2008, Methods.

Atrial fibrillation-associated minK38G/S polymorphism modulates delayed rectifier current and membrane localization.

S. Nattel, T. Hébert, J. Ehrlich, 2005, Cardiovascular research.

Biasing the prostaglandin F2α receptor responses toward EGFR-dependent transactivation of MAPK.

T. Hébert, S. Laporte, Brandon Zimmerman, 2012, Molecular endocrinology.

Effects of Resveratrol (trans-3,5,4′-Trihydroxystilbene) Treatment on Cardiac Remodeling following Myocardial Infarction

S. Nattel, J. Tardif, A. Maguy, 2007, Journal of Pharmacology and Experimental Therapeutics.

PPIP5K1 Suppresses Etoposide-triggered Apoptosis

T. Hébert, G. J. Miller, Gayane Machkalyan, 2016, Journal of molecular signaling.

Shaky ground - The nature of metastable GPCR signalling complexes

T. Hébert, Rory Sleno, T. Hébert, 2019, Neuropharmacology.

Asymmetric Recruitment of β-Arrestin1/2 by the Angiotensin II Type I and Prostaglandin F2α Receptor Dimer

D. Devost, A. Inoue, T. Hébert, 2019, Front. Endocrinol..

Conformational biosensors reveal allosteric interactions between heterodimeric AT1 angiotensin and prostaglandin F2α receptors

D. Devost, J. Aoki, A. Inoue, 2017, The Journal of Biological Chemistry.

Gβγ subunits co-localize with RNA polymerase II and regulate transcription in cardiac fibroblasts.

Shahriar M. Khan, J. Trempe, Jace Jones-Tabah, 2023, The Journal of biological chemistry.

A novel interaction between Gβγ and RNA polymerase II regulates cardiac fibrosis

Shahriar M. Khan, Jace Jones-Tabah, J. Tanny, 2018, bioRxiv.

Functional selectivity profiling of the angiotensin II type 1 receptor using pathway-wide BRET signaling sensors

R. Leduc, D. Devost, M. Bouvier, 2018, Science Signaling.

Kir3 channel signalling complexes in cardiac arrhythmias

T. Hébert, Peter Zylbergold, T. Hébert, 2012 .

C5L2 and C5aR interaction in adipocytes and macrophages: insights into adipoimmunology.

K. Cianflone, D. Devost, T. Hébert, 2013, Cellular signalling.

Detecting and imaging protein-protein interactions during G protein-mediated signal transduction in vivo and In situ by using fluorescence-based techniques

T. Hébert, C. Galés, R. V. Rebois, 2006, Cell Biochemistry and Biophysics.

A novel, radiolabel-free pulse chase strategy to study Kir3 channel ontogeny

T. Hébert, Peter Zylbergold, Rory Sleno, 2013, Journal of receptor and signal transduction research.

In vivo detection of GPCR-dependent signaling using fiber photometry and FRET-based biosensors.

Jace Jones-Tabah, H. Mohammad, P. Clarke, 2021, Methods.

Designing BRET-based conformational biosensors for G protein-coupled receptors.

D. Devost, T. Hébert, E. Goupil, 2016, Methods.

GPCR Retreat 2014: a good view leads to many discoveries!

P. Chidiac, T. Hébert, T. Hébert, 2015, Journal of receptor and signal transduction research.

Cross-Talk between Signaling Pathways Can Generate Robust Oscillations in Calcium and cAMP

Peter S. Swain, Fernando Siso-Nadal, Jeffrey J. Fox, 2009, PloS one.

Lipidated peptides derived from intracellular loops 2 and 3 of the urotensin II receptor act as biased allosteric ligands

E. Novellino, A. Carotenuto, J. Tanny, 2021, The Journal of biological chemistry.

Membrane-tethered peptides derived from intracellular loops 2 and 3 of the urotensin II receptor act as allosteric biased ligands

E. Novellino, A. Carotenuto, J. Tanny, 2020, bioRxiv.

Role of specific protein kinase C isoforms in modulation of β1- and β2-adrenergic receptors

H. Rindt, T. Hébert, B. Allen, 2005 .

Kir3 channel ontogeny – the role of Gβγ subunits in channel assembly and trafficking

Shahriar M. Khan, Ashley M. Jacobi, T. Hébert, 2014, Front. Cell. Neurosci..

Heterotrimeric G proteins form stable complexes with adenylyl cyclase and Kir3.1 channels in living cells

M. Robitaille, M. Bouvier, T. Hébert, 2006, Journal of Cell Science.

Gβ Residues That Do Not Interact with Gα Underlie Agonist-independent Activity of K+ Channels*

T. Hébert, D. Logothetis, L. Robillard, 2002, The Journal of Biological Chemistry.

Exploring the use of intracellular and extracellular allosteric modulators to understand GPCR signaling

T. Hébert, D. Chatenet, B. Allen, 2022, Allosteric Modulation of G Protein-Coupled Receptors.

Cellular and subcellular context determine outputs from signaling biosensors.

D. Devost, M. Bouvier, T. Hébert, 2016, Methods in cell biology.

Measuring Recruitment of β-Arrestin to G Protein-Coupled Heterodimers Using Bioluminescence Resonance Energy Transfer.

D. Devost, T. Hébert, D. Fillion, 2019, Methods in molecular biology.

Conformational profiling of the AT 1 angiotensin II receptor 1 Conformational profiling of the AT 1 angiotensin II receptor reflects biased agonism , G protein coupling and cellular context

D. Devost, J. Aoki, A. Inoue, 2017 .

Angiotensin II Type I and Prostaglandin F2α Receptors Cooperatively Modulate Signaling in Vascular Smooth Muscle Cells*

D. Devost, T. Hébert, S. Laporte, 2014, The Journal of Biological Chemistry.

Combining Conformational Profiling of GPCRs with CRISPR/Cas9 Gene Editing Approaches.

D. Devost, A. Inoue, T. Hébert, 2019, Methods in molecular biology.

Conformational Profiling of the 5-HT 2A Receptor Using FlAsH BRET

D. Devost, Jace Jones-Tabah, T. Hébert, 2018 .

Dofetilide block involves interactions with open and inactivated states of HERG channels

Stanley Nattel, S. Nattel, T. Hébert, 2002, Pflügers Archiv - European Journal of Physiology.

Gbeta residues that do not interact with Galpha underlie agonist-independent activity of K+ channels.

T. Hébert, D. Logothetis, L. Robillard, 2002, Journal of Biological Chemistry.

Allosteric modulation of GPCR-induced β-arrestin trafficking and signaling by a synthetic intrabody

D. Devost, J. Selent, T. Hébert, 2022, Nature Communications.

Photoreleasable ligands to study intracrine angiotensin II signalling

S. Nattel, N. Doucet, B. Folch, 2015, The Journal of physiology.

G Protein-coupled Receptors Form Stable Complexes with Inwardly Rectifying Potassium Channels and Adenylyl Cyclase*

N. Lavine, H. V. Van Tol, L. Pei, 2002, The Journal of Biological Chemistry.

Novel tools for use in bioluminescence resonance energy transfer (BRET) assays.

M. Robitaille, T. Hébert, A. Baragli, 2009, Methods in molecular biology.

State‐dependent barium block of wild‐type and inactivation‐deficient HERG channels in Xenopus oocytes

S Nattel, M Courtemanche, M. Courtemanche, 2000, The Journal of physiology.

Opioid and chemokine receptor heterodimers: arranged marriages or dangerous liaisons?

T. Hébert, 2008, Biochemical Journal.

New insights about the peculiar role of the 28–38 C‐terminal segment and some selected residues in PACAP for signaling and neuroprotection

D. Devost, T. Hébert, M. Létourneau, 2018, Biochemical pharmacology.