L. Murphy

发表

Molecular interpretation of ERK signal duration by immediate early gene products

Rey-Huei Chen, J. Blenis, D. Fingar, 2002, Nature Cell Biology.

A Network of Immediate Early Gene Products Propagates Subtle Differences in Mitogen-Activated Protein Kinase Signal Amplitude and Duration

Jeffrey P. MacKeigan, J. Blenis, L. Murphy, 2004, Molecular and Cellular Biology.

Functional CRISPR screening identifies the ufmylation pathway as a regulator of SQSTM1/p62

John A. Tallarico, R. Xavier, C. Mickanin, 2016, eLife.

Guidelines for the use and interpretation of assays for monitoring autophagy in higher eukaryotes

John L Cleveland, Masaaki Komatsu, Katsuhiko Kitamoto, 2008, Autophagy.

Indoleacrylic Acid Produced by Commensal Peptostreptococcus Species Suppresses Inflammation.

Daniel J. O'Connell, C. Huttenhower, E. Franzosa, 2017, Cell host & microbe.

Down-Regulation of Class II Phosphoinositide 3-Kinase α Expression below a Critical Threshold Induces Apoptotic Cell Death

G. Caponigro, P. Finan, L. A. Gaither, 2008, Molecular Cancer Research.

Identification and characterization of NVP-BEZ235, a new orally available dual phosphatidylinositol 3-kinase/mammalian target of rapamycin inhibitor with potent in vivo antitumor activity

Daniela Gabriel, Doriano Fabbro, Pascal Furet, 2008, Molecular Cancer Therapeutics.

MK-STYX, a Catalytically Inactive Phosphatase Regulating Mitochondrially Dependent Apoptosis

Karl J. Dykema, D. Green, K. Dykema, 2011, Molecular and Cellular Biology.

Small-molecule inhibitors: bULKing up mTOR inhibition.

L. Murphy, Leon O. Murphy, Jonathan M Goodwin, 2015, Nature chemical biology.

Vps34 PI 3-kinase inactivation enhances insulin sensitivity through reprogramming of mitochondrial metabolism

Julia M. Hill, C. Peddie, L. Collinson, 2017, Nature Communications.

Atg4b-Dependent Autophagic Flux Alleviates Huntington’s Disease Progression

T. Bouwmeester, C. Genoud, Ivan Galimberti, 2013, PloS one.

Autophagy Assays for Biological Discovery and Therapeutic Development.

L. Murphy, N. Mizushima, Leon O. Murphy, 2020, Trends in biochemical sciences.

Quantitative visualization of autophagy induction by mTOR inhibitors.

Christopher J. Wilson, L. Murphy, Phil Bergman, 2012, Methods in molecular biology.

Physiological Concentrations of Insulin Augment Pancreatic Cancer Cell Proliferation and Glucose Utilization By Activating MAP Kinase, PI3 Kinase and Enhancing GLUT-1 Expression

X. Ding, T. Adrian, J. Permert, 2000, Pancreas.

Discovery of a Brain Penetrant ATP-competitive Inhibitor of the Mechanistic Target of Rapamycin (mTOR) for CNS disorders.

D. Curtis, F. Lombardo, Christopher J. Wilson, 2020, Journal of medicinal chemistry.

Amylin gene expression mediated by cAMP/PKA and transcription factors HNF-1 and NFY

M. Cluck, J. Knezetic, T. Adrian, 2003, Molecular and Cellular Endocrinology.

MAPK signal specificity: the right place at the right time.

J. Blenis, L. Murphy, Leon O Murphy, 2006, Trends in biochemical sciences.

Molecular definitions of autophagy and related processes

A. Ballabio, Nektarios Tavernarakis, D. Green, 2017, The EMBO journal.

Bidirectional Transport of Amino Acids Regulates mTOR and Autophagy

Jeffrey P. MacKeigan, Charles Kung, Bailin Zhang, 2009, Cell.

Selective VPS34 inhibitor blocks autophagy and uncovers a role for NCOA4 in ferritin degradation and iron homeostasis in vivo

John A. Tallarico, M. Schirle, Christopher J. Wilson, 2014, Nature Cell Biology.

Activation of a metabolic gene regulatory network downstream of mTOR complex 1.

Qicheng Ma, Clary B Clish, Regina K. Gorski, 2010, Molecular cell.

GABARAP sequesters the FLCN-FNIP tumor suppressor complex to couple autophagy with lysosomal biogenesis.

A. Ballabio, Aylwin Ng, B. Appleton, 2021, Science advances.

Potential therapeutic applications of autophagy

D. Rubinsztein, D. Klionsky, J. Gestwicki, 2007, Nature Reviews Drug Discovery.

Macroautophagy is dispensable for growth of KRAS mutant tumors and chloroquine efficacy

Gregory McAllister, Zuncai Wang, Gregory R. Hoffman, 2015, Proceedings of the National Academy of Sciences.

TMEM41B is a novel regulator of autophagy and lipid mobilization

R. Xavier, C. Genoud, C. Antczak, 2018, EMBO reports.

Autophagy-Independent Lysosomal Targeting Regulated by ULK1/2-FIP200 and ATG9.

R. Xavier, L. Murphy, Zuncai Wang, 2017, Cell reports.

Sensitized RNAi screen of human kinases and phosphatases identifies new regulators of apoptosis and chemoresistance

Jeffrey P. MacKeigan, J. Blenis, L. Murphy, 2005, Nature Cell Biology.

TBC1D7 is a third subunit of the TSC1-TSC2 complex upstream of mTORC1.

P. Finan, D. Kwiatkowski, J. Asara, 2012, Molecular cell.

Spatially Separate Docking Sites on ERK2 Regulate Distinct Signaling Events In Vivo

J. Blenis, L. Murphy, J. MacKeigan, 2005, Current Biology.

Vps34 PI 3-kinase inactivation enhances insulin sensitivity through reprogramming of mitochondrial metabolism

Julia M. Hill, C. Peddie, L. Collinson, 2017, Nature Communications.

Potent, Selective, and Orally Bioavailable Inhibitors of VPS34 Provide Chemical Tools to Modulate Autophagy in Vivo.

P. Finan, M. Glick, P. Furet, 2016, ACS medicinal chemistry letters.

PIKfyve, a class III PI kinase, is the target of the small molecular IL-12/IL-23 inhibitor apilimod and a player in Toll-like receptor signaling.

John A. Tallarico, Jeffrey A. Porter, P. De Camilli, 2013, Chemistry & biology.

Defective Autophagy and mTORC1 Signaling in Myotubularin Null Mice

Jeffrey A. Porter, P. Finan, K. Walsh, 2012, Molecular and Cellular Biology.

1 Developmental and Molecular Pathways, Novartis Institutes for BioMedical Research,

Jeffrey A. Porter, P. Finan, K. Walsh, 2012 .

Association of MTOR Mutations With Developmental Brain Disorders, Including Megalencephaly, Focal Cortical Dysplasia, and Pigmentary Mosaicism.

Beth K. Martin, Michael P. Morrissey, J. Shendure, 2016, JAMA neurology.

Total Lipopolysaccharide from the Human Gut Microbiome Silences Toll-Like Receptor Signaling

T. Cullen, Sahar Abubucker, L. Murphy, 2017, mSystems.

Targeting quiescent leukemic stem cells using second generation autophagy inhibitors

G. Helgason, T. Holyoake, E. Gottlieb, 2018, Leukemia.

Relieving Autophagy and 4EBP1 from Rapamycin Resistance

Daniel J. Klionsky, Beat Nyfeler, Christopher J. Wilson, 2011, Molecular and Cellular Biology.

Identification of Elongation Factor G as the Conserved Cellular Target of Argyrin B

Christopher J. Wilson, J. Tallarico, R. Riedl, 2012, PloS one.

Receptors and Ligands for Autocrine Growth Pathways Are Up-regulated When Pancreatic Cancer Cells Are Adapted to Serum-Free Culture

J. Knezetic, T. Adrian, J. Permert, 2001, Pancreas.

Pancreatic cancer cells require an EGF receptor-mediated autocrine pathway for proliferation in serum-free conditions

R. Murphy, S. Lovas, M. Cluck, 2001, British Journal of Cancer.

The E3 Ligase MuRF1 degrades myosin heavy chain protein in dexamethasone-treated skeletal muscle.

S. Rakhilin, C. Patterson, D. Glass, 2007, Cell metabolism.

Graded Mitogen-Activated Protein Kinase Activity Precedes Switch-Like c-Fos Induction in Mammalian Cells

Jeffrey P. MacKeigan, J. Blenis, L. Murphy, 2005, Molecular and Cellular Biology.

and John Blenis Amplitude and Duration Mitogen-Activated Protein Kinase Signal Products Propagates Subtle Differences in A Network of Immediate Early Gene

J. Blenis, L. Murphy, J. MacKeigan, 2003 .

Characterization of Regulatory Events Associated with Membrane Targeting of p90 Ribosomal S6 Kinase 1

J. Blenis, S. Richards, L. Murphy, 2001, Molecular and Cellular Biology.

Autophagy-Independent L ysosomal Targeting Regulated by ULK 1 / 2-FIP 200 and ATG 9 Graphical Abstract Highlights

R. Xavier, L. Murphy, Zuncai Wang, 2017 .

RAD001 Enhances the Potency of BEZ235 to Inhibit mTOR Signaling and Tumor Growth

J. Lehár, Anupama Reddy, P. Finan, 2012, PloS one.

An iron-dependent metabolic vulnerability underlies VPS34-dependence in RKO cancer cells

D. Wiederschain, M. Beibel, S. Menon, 2020, PloS one.

GABARAP membrane conjugation sequesters the FLCN-FNIP tumor suppressor complex to activate TFEB and lysosomal biogenesis

A. Ballabio, M. Chance, Aylwin Ng, 2021, bioRxiv.

A terpene nucleoside from M. tuberculosis induces lysosomal lipid storage in foamy macrophages

S. Fortune, J. Keane, Sahadevan Raman, 2023, The Journal of clinical investigation.