C. Bezzina

C. Bode, C. Bezzina, M. Zehender, 2020, Europace : European pacing, arrhythmias, and cardiac electrophysiology : journal of the working groups on cardiac pacing, arrhythmias, and cardiac cellular electrophysiology of the European Society of Cardiology.

ALPK3: a full spectrum cardiomyopathy gene?

C. Bezzina, R. Walsh, 2021, European heart journal.

Coxsackie and adenovirus receptor is a modifier of cardiac conduction and arrhythmia vulnerability in the setting of myocardial ischemia.

R. Coronel, J. D. de Bakker, C. D. dos Remedios, 2014, Journal of the American College of Cardiology.

Reclassification of a likely pathogenic Dutch founder variant in KCNH2; implications of reduced penetrance

T. Koopmann, C. Bezzina, A. Wilde, 2022, bioRxiv.

Biallelic loss-of-function variants in PLD1 cause congenital right-sided cardiac valve defects and neonatal cardiomyopathy.

P. de Knijff, B. Mulder, H. Brown, 2021, The Journal of clinical investigation.

Systematic large-scale assessment of the genetic architecture of left ventricular noncompaction reveals diverse etiologies

Angharad M Roberts, D. O’Regan, M. Yacoub, 2021, Genetics in Medicine.

Homozygous frameshift mutations in FAT1 cause a syndrome characterized by colobomatous-microphthalmia, ptosis, nephropathy and syndactyly

V. Lougaris, A. Plebani, S. Lyonnet, 2019, Nature Communications.

Common genetic variants improve risk stratification after the atrial switch operation for transposition of the great arteries.

M. Jongbloed, B. Mulder, F. Meijboom, 2022, International journal of cardiology.

Common variants at SCN5A-SCN10A and HEY2 are associated with Brugada syndrome, a rare disease with high risk of sudden cardiac death

R. Redon, E. Behr, D. Roden, 2013, Nature Genetics.

Obesity Cardiovascular Disease and the Failure of Public Health Education

S. Boekholdt, H. Katus, C. Bezzina, 2022 .

Dilation of the Aorta Ascendens Forms Part of the Clinical Spectrum of HCN4 Mutations.

A. Wilde, S. Boekholdt, H. Katus, 2016, Journal of the American College of Cardiology.

A polymorphism in KCNH2 (HERG) hastens cardiac repolarization

J. Erdmann, H. Schunkert, H. Tan, 2003 .

Developmental aspects of long QT syndrome type 3 and Brugada syndrome on the basis of a single SCN5A mutation in childhood.

M. P. van den Berg, C. Bezzina, A. Wilde, 2005, Journal of the American College of Cardiology.

A large family characterised by nocturnal sudden death.

M. P. van den Berg, J. Haaksma, J. Brouwer, 2002, Netherlands heart journal : monthly journal of the Netherlands Society of Cardiology and the Netherlands Heart Foundation.

Substitution of a conserved alanine in the domain IIIS4-S5 linker of the cardiac sodium channel causes long QT syndrome.

A. Wilde, E. Schulze-Bahr, C. Bezzina, 2005, Cardiovascular research.

A novel LQT3 mutation implicates the human cardiac sodium channel domain IVS6 in inactivation kinetics.

H. Jongsma, C. Bezzina, A. Wilde, 2003, Cardiovascular research.

Electrophysiological Abnormalities in VLCAD Deficient hiPSC-Cardiomyocytes Can Be Improved by Lowering Accumulation of Fatty Acid Oxidation Intermediates

S. Ferdinandusse, R. Wanders, R. Coronel, 2020, International journal of molecular sciences.

Pharmacological rescue of mutant ion channels.

H. Tan, C. Bezzina, 2002, Cardiovascular research.

Pro-arrhythmic effects of elevated branched chain amino acid levels.

C. Gieger, A. Peters, M. Müller-Nurasyid, 2021, Cardiovascular research.

Genome-wide association of multiple complex traits in outbred mice by ultra low-1 coverage sequencing 2

R. Mott, S. Wells, B. Yee, 2016 .

Diversity in cardiac sodium channel disease phenotype in transgenic mice carrying a single SCN5A mutation

A. Wilde, J. D. Bakker, C. Bezzina, 2007, Netherlands heart journal : monthly journal of the Netherlands Society of Cardiology and the Netherlands Heart Foundation.

Dilated cardiomyopathy due to sodium channel dysfunction: what is the connection?

C. Bezzina, C. Remme, 2008, Circulation. Arrhythmia and electrophysiology.

Cardiac sodium channel and inherited arrhythmia syndromes.

A. Wilde, C. Bezzina, A. Wilde, 2001, Cardiovascular research.

Familial primary arrhythmia syndromes: Nice to know or need to know.

A. Wilde, H. Tan, C. Bezzina, 2002, Netherlands heart journal : monthly journal of the Netherlands Society of Cardiology and the Netherlands Heart Foundation.

Abstract 1971: Genome-wide Association Study Identifies Novel Genomic Regions Associated With Drug-induced Long Qt Syndrome

Yusuke Nakamura, D. Roden, A. Pfeufer, 2009 .

Genetic control of sodium channel function.

H. Tan, C. Bezzina, A. Wilde, 2003, Cardiovascular research.

Channel Mutation Causing Both Long-qt and Brugada Syndromes + a Single Na

A. Wilde, M. P. van den Berg, C. Bezzina, 2022 .

Polymorphisms in human connexin40 gene promoter are associated with increased risk of hypertension in men

J. Ruijter, H. Jongsma, W. Spiering, 2006, Journal of hypertension.

Abstract 4412: High Density tagSNP Candidate Gene Analysis Identifies IKs as a Major Modulator of Genetic Susceptibility to Drug Induced Long QT Syndrome

T. Meitinger, H. Wichmann, D. Roden, 2008 .

Bioinformatic analysis of a plakophilin-2-dependent transcription network: implications for the mechanisms of arrhythmogenic right ventricular cardiomyopathy in humans and in boxer dogs.

C. Bezzina, M. Delmar, J. Montnach, 2018, Europace : European pacing, arrhythmias, and cardiac electrophysiology : journal of the working groups on cardiac pacing, arrhythmias, and cardiac cellular electrophysiology of the European Society of Cardiology.

Arrhythmogenic cardiomyopathy: pathology, genetics, and concepts in pathogenesis

D. Judge, C. Basso, C. Bezzina, 2017, Cardiovascular research.

Large-Scale Gene-Centric Analysis Identifies Novel Variants for Coronary Artery Disease

Simon C. Potter, Thomas W. Mühleisen, Benjamin J. Wright, 2011, PLoS genetics.

Inherited arrhythmia syndromes

C. Bezzina, Isabella Mengarelli, 2017 .

Cardiac Repolarization in Health and Disease.

C. Bezzina, B. Boukens, J. Offerhaus, 2022, JACC. Clinical electrophysiology.

Genomic approaches for the elucidation of genes and gene networks underlying cardiovascular traits

C. Bezzina, M. Adriaens, 2018, Biophysical Reviews.

Blood Pressure-Associated Genetic Variants in the Natriuretic Peptide Receptor 1 Gene Modulate Guanylate Cyclase Activity.

C. Newton-Cheh, N. Lahrouchi, C. Bezzina, 2019, Circulation. Genomic and precision medicine.

Subsequent Event Risk in Individuals With Established Coronary Heart Disease

Yan V. Sun, P. Deloukas, T. Lehtimäki, 2019, Circulation. Genomic and precision medicine.

1 Subsequent Event Risk in Individuals with Established Coronary Heart Disease : Design and Rationale of the GENIUS-CHD Consortium Running title :

Yan V. Sun, Ayman, Clara, 2019 .

Quantitative trait loci for electrocardiographic parameters and arrhythmia in the mouse.

R. Coronel, B. Scicluna, C. Bezzina, 2011, Journal of molecular and cellular cardiology.

A Cardiac Sodium Channel Mutation Cosegregates With a Rare Connexin40 Genotype in Familial Atrial Standstill

H. Jongsma, L. Sandkuijl, C. Bezzina, 2003, Circulation research.

Genetics of sudden cardiac death.

S. Priori, N. Lahrouchi, C. Bezzina, 2015, Circulation research.

Identification of a Sudden Cardiac Death Susceptibility Locus at 2q24.2 through Genome-Wide Association in European Ancestry Individuals

A. Hofman, A. Uitterlinden, E. Boerwinkle, 2011, PLoS genetics.

Integrative Genomic Approach Identifies Multiple Genes Involved in Cardiac Collagen Deposition

D. Arends, P. Moerland, B. Scicluna, 2014, Circulation. Cardiovascular genetics.

The cardiac sodium channel displays differential distribution in the conduction system and transmural heterogeneity in the murine ventricular myocardium

A. Wilde, J. D. de Bakker, T. V. van Veen, 2009, Basic Research in Cardiology.

Cardiac sodium channel overlap syndromes: different faces of SCN5A mutations.

A. Wilde, C. Bezzina, C. Remme, 2008, Trends in cardiovascular medicine.

Genome-wide association studies of cardiac electrical phenotypes

N. Lahrouchi, C. Bezzina, R. Jabbari, 2020, Cardiovascular research.

Gene-centric meta-analysis in 87,736 individuals of European ancestry identifies multiple blood-pressure-related loci.

Christian Gieger, Xiaofeng Zhu, Tom R. Gaunt, 2014, American journal of human genetics.

Whole Exome Sequencing Reveals the Major Genetic Contributors to Nonsyndromic Tetralogy of Fallot

Kathryn E. Hentges, Matthieu J. Miossec, G. Lathrop, 2019, Circulation research.

Deleterious genetic variants in NOTCH1 are a major contributor to the incidence of non-syndromic Tetralogy of Fallot

Kathryn E. Hentges, Matthieu J. Miossec, G. Bourque, 2018, bioRxiv.

Common genetic variants and modifiable risk factors underpin hypertrophic cardiomyopathy susceptibility and expressivity

M. Farrall, C. Autore, S. Petersen, 2021, Nature Genetics.

Shared genetic pathways contribute to risk of hypertrophic and dilated cardiomyopathies with opposite directions of effect

P. Elliott, P. Matthews, D. O’Regan, 2020, Nature Genetics.

Genome-wide association of multiple complex traits in outbred mice by ultra low-coverage sequencing

Steve D. M. Brown, R. Mott, S. Wells, 2016, Nature Genetics.

Natural genetic variation of the cardiac transcriptome in non-diseased donors and patients with dilated cardiomyopathy

E. Petretto, Y. Pinto, E. Creemers, 2017, Genome Biology.

Genome-wide association analyses identify new Brugada syndrome risk loci and highlight a new mechanism of sodium channel regulation in disease susceptibility

R. Redon, K. Strauch, P. Lambiase, 2022, Nature Genetics.

Common Genetic Variants Contribute to Risk of Transposition of the Great Arteries

M. Nóbrega, T. Meitinger, M. Lathrop, 2021, Circulation research.

Genome-wide association study of multiple congenital heart disease phenotypes identifies a susceptibility locus for atrial septal defect at chromosome 4p16

S. Heath, G. Lathrop, M. Farrall, 2013, Nature Genetics.

Large scale genome-wide association analyses identify novel genetic loci and mechanisms in hypertrophic cardiomyopathy

Kevin Knight, D. O’Regan, Y. Pinto, 2023, medRxiv.

Role of common and rare variants in SCN10A: results from the Brugada syndrome QRS locus gene discovery collaborative study.

R. Redon, E. Behr, D. Roden, 2015, Cardiovascular research.

Common variants at SCN5A-SCN10A and HEY2 are associated with Brugada syndrome, a rare disease with high risk of sudden cardiac death

Dan M Roden, Beverley Balkau, Pierre Lindenbaum, 2013, Nature Genetics.

Genome Wide Analysis of Drug-Induced Torsades de Pointes: Lack of Common Variants with Large Effect Sizes

R. Altman, Yufeng Shen, Yusuke Nakamura, 2013, PloS one.

Induced pluripotent stem cell derived cardiomyocytes as models for cardiac arrhythmias

C. Mummery, C. Bezzina, A. Wilde, 2012, Front. Physio..

European Heart Rhythm Association (EHRA)/Heart Rhythm Society (HRS)/Asia Pacific Heart Rhythm Society (APHRS)/Latin American Heart Rhythm Society (LAHRS) Expert Consensus Statement on the state of genetic testing for cardiac diseases

E. Ashley, A. Bollmann, E. Kaufman, 2022, Europace : European pacing, arrhythmias, and cardiac electrophysiology : journal of the working groups on cardiac pacing, arrhythmias, and cardiac cellular electrophysiology of the European Society of Cardiology.

E. Ashley, E. Kaufman, E. Behr, 2022, Heart rhythm.

When genetic burden reaches threshold

C. Bezzina, R. Walsh, R. Tadros, 2020, European heart journal.

Dissecting the Genetic Basis of the ECG as a Means of Understanding Mechanisms of Arrhythmia.

R. Coronel, C. Bezzina, R. Tadros, 2017, Circulation. Cardiovascular genetics.

Genetics and genomics of arrhythmic risk: current and future strategies to prevent sudden cardiac death

E. Behr, M. Ackerman, C. Bezzina, 2021, Nature Reviews Cardiology.

Enhancing rare variant interpretation in inherited arrhythmias through quantitative analysis of consortium disease cohorts and population controls

R. Redon, P. Lambiase, P. Ellinor, 2020, Genetics in medicine : official journal of the American College of Medical Genetics.

Transethnic Genome-Wide Association Study Provides Insights in the Genetic Architecture and Heritability of Long QT Syndrome

T. Werge, P. Ellinor, S. Priori, 2020, Circulation.

Utility of Post-Mortem Genetic Testing in Cases of Sudden Arrhythmic Death Syndrome

J. Skinner, E. Behr, M. Sheppard, 2017, Journal of the American College of Cardiology.

Voltage‐gated sodium channels: Action players with many faces

T. Koopmann, C. Bezzina, A. Wilde, 2006, Annals of medicine.

Cardiomyocytes Derived From Pluripotent Stem Cells Recapitulate Electrophysiological Characteristics of an Overlap Syndrome of Cardiac Sodium Channel Disease

C. Mummery, C. Bezzina, Richard P. Davis, 2012, Circulation.

Identification of FOXP1 Deletions in Three Unrelated Patients with Mental Retardation and Significant Speech and Language Deficits

A. Monaco, D. Horn, T. Strom, 2010, Human mutation.

Patch-Clamp Recording from Human Induced Pluripotent Stem Cell-Derived Cardiomyocytes: Improving Action Potential Characteristics through Dynamic Clamp

R. Wilders, C. Bezzina, A. Verkerk, 2017, International journal of molecular sciences.

Complex inheritance for susceptibility to sudden cardiac death.

R. Pazoki, C. Bezzina, M. Tanck, 2013, Current pharmaceutical design.

Common genetic variation modulating cardiac ECG parameters and susceptibility to sudden cardiac death.

C. Bezzina, M. Tanck, I. Kolder, 2012, Journal of molecular and cellular cardiology.

Genetics of congenital heart disease: the contribution of the noncoding regulatory genome

C. Bezzina, V. Christoffels, A. Postma, 2015, Journal of Human Genetics.

UvA-DARE ( Digital Academic Repository ) Pathophysiological mechanisms of arrhythmogenic right ventricular disorders

Mark Potse, Ruben Coronel, Arthur A M Wilde, 2013 .

Type of SCN5A mutation determines clinical severity and degree of conduction slowing in loss-of-function sodium channelopathies.

H. Tan, F. Sacher, V. Probst, 2009, Heart rhythm.

Role of sequence variations in the human ether-a-go-go-related gene (HERG, KCNH2) in the Brugada syndrome.

Arthur A M Wilde, Dongxin Lin, Ronald Wilders, 2005, Cardiovascular research.

Genotype-phenotype relationship in Brugada syndrome: electrocardiographic features differentiate SCN5A-related patients from non-SCN5A-related patients.

G. Breithardt, W. Haverkamp, L. Eckardt, 2002, Journal of the American College of Cardiology.

The yield of postmortem genetic testing in sudden death cases with structural findings at autopsy

J. Skinner, E. Behr, M. Sheppard, 2019, European Journal of Human Genetics.

Sodium channel (dys)function and cardiac arrhythmias.

C. Bezzina, C. Remme, Connie R Bezzina, 2010, Cardiovascular therapeutics.

Sodium Channel Remodeling in Subcellular Microdomains of Murine Failing Cardiomyocytes

C. Bezzina, E. Rothenberg, A. Leo-Macias, 2017, Journal of the American Heart Association.

Anti-arrhythmic potential of the late sodium current inhibitor GS-458967 in murine Scn5a-1798insD+/− and human SCN5A-1795insD+/− iPSC-derived cardiomyocytes

C. Bezzina, A. Wilde, A. Verkerk, 2017, Cardiovascular research.

Dissection of a Quantitative Trait Locus for PR Interval Duration Identifies Tnni3k as a Novel Modulator of Cardiac Conduction

D. Marchuk, P. Moerland, B. Scicluna, 2012, PLoS genetics.

Tubulin polymerization modifies cardiac sodium channel expression and gating.

J. Ruijter, H. Tan, A. V. van Ginneken, 2010, Cardiovascular research.

Genetically Determined Differences in Sodium Current Characteristics Modulate Conduction Disease Severity in Mice With Cardiac Sodium Channelopathy

R. Houlgatte, H. Tan, J. D. de Bakker, 2009, Circulation research.

Inherited cardiac arrhythmias

P. Schwartz, C. Antzelevitch, M. Borggrefe, 2020, Nature Reviews Disease Primers.

Epidemiology of inherited arrhythmias

C. Bezzina, A. Wilde, J. Offerhaus, 2019, Nature Reviews Cardiology.

Calmodulin mutations and life-threatening cardiac arrhythmias: insights from the International Calmodulinopathy Registry.

E. Behr, P. Schwartz, G. Parati, 2019, European heart journal.

The Brugada Syndrome Susceptibility Gene HEY2 Modulates Cardiac Transmural Ion Channel Patterning and Electrical Heterogeneity

B. de Jonge, R. Coronel, R. Wilders, 2017, Circulation research.

Switch From Fetal to Adult SCN5A Isoform in Human Induced Pluripotent Stem Cell–Derived Cardiomyocytes Unmasks the Cellular Phenotype of a Conduction Disease–Causing Mutation

A. Wilde, E. Schulze-Bahr, C. Bezzina, 2017, Journal of the American Heart Association.

Beyond the One Gene-One Disease Paradigm.

C. Bezzina, M. Delmar, C. Remme, 2019, Circulation.

Analysis for Genetic Modifiers of Disease Severity in Patients With Long-QT Syndrome Type 2

T. Meitinger, D. Roden, A. Pfeufer, 2015, Circulation. Cardiovascular genetics.

Genetics of sudden cardiac death caused by ventricular arrhythmias

H. Tan, C. Bezzina, R. Marsman, 2014, Nature Reviews Cardiology.

Genomics of cardiac electrical function.

C. Bezzina, E. Lodder, Elisabeth M. Lodder, 2014, Briefings in functional genomics.

SNPs Identified as Modulators of ECG Traits in the General Population Do Not Markedly Affect ECG Traits during Acute Myocardial Infarction nor Ventricular Fibrillation Risk in This Condition

A. Wilde, R. Pazoki, C. Bezzina, 2013, PloS one.

Genetic Basis of Ventricular Arrhythmias

R. Pazoki, C. Bezzina, A. Wilde, 2010, Current cardiovascular risk reports.

Genome-wide association study identifies a susceptibility locus at 21q21 for ventricular fibrillation in acute myocardial infarction

X. Jouven, S. Chugh, T. Meitinger, 2010, Nature Genetics.

The Primary Arrhythmia Syndromes: Same Mutation, Different Manifestations. Are We Starting to Understand Why?

B. Scicluna, C. Bezzina, Connie R Bezzina, 2008, Journal of cardiovascular electrophysiology.

A common polymorphism in KCNH2 (HERG) hastens cardiac repolarization.

J. Erdmann, H. Schunkert, A. Wilde, 2003, Cardiovascular research.

Long QT syndrome caused by a large duplication in the KCNH2 (HERG) gene undetectable by current polymerase chain reaction-based exon-scanning methodologies.

T. Koopmann, C. Bezzina, A. Wilde, 2006, Heart rhythm.

hiPSC-derived cardiomyocytes from Brugada Syndrome patients without identified mutations do not exhibit clear cellular electrophysiological abnormalities

Arie O. Verkerk, Isabella Mengarelli, Hanno L. Tan, 2016, Scientific Reports.

Characterization of a novel SCN5A mutation associated with Brugada syndrome reveals involvement of DIIIS4-S5 linker in slow inactivation.

A. Wilde, H. Tan, A. Mugelli, 2007, Cardiovascular research.

A comprehensive evaluation of the genetic architecture of sudden cardiac arrest

O. Franco, A. Hofman, A. Uitterlinden, 2018, European heart journal.

Familial Sudden Death Is an Important Risk Factor for Primary Ventricular Fibrillation: A Case-Control Study in Acute Myocardial Infarction Patients

A. Wilde, K. Koch, A. Gorgels, 2006, Circulation.

Genetic Basis for Cardiac Arrhythmias

A. Wilde, C. Bezzina, A. Wilde, 2007 .

Genetic Loci Influencing Myocardial Mass

A. Peters, J. Hirschhorn, P. Macfarlane, 2017 .

Genome-Wide Polyadenylation Maps Reveal Dynamic mRNA 3'-End Formation in the Failing Human Heart.

Ran Elkon, Reuven Agami, Stuart A Cook, 2016, Circulation research.

GATA6 mutations: Characterization of two novel patients and a comprehensive overview of the GATA6 genotypic and phenotypic spectrum

B. Mulder, R. Bökenkamp, D. Barge-Schaapveld, 2019, American journal of medical genetics. Part A.

The role of renin–angiotensin–aldosterone system polymorphisms in phenotypic expression of MYBPC3-related hypertrophic cardiomyopathy

A. Wilde, C. Bezzina, M. Tanck, 2012, European Journal of Human Genetics.

Exclusion of multiple candidate genes and large genomic rearrangements in SCN5A in a Dutch Brugada syndrome cohort.

A. Moorman, T. Koopmann, C. Bezzina, 2007, Heart rhythm.

Association of Chromosome 9p21 With Subsequent Coronary Heart Disease Events

Yan V. Sun, P. Deloukas, T. Lehtimäki, 2019, Circulation. Genomic and precision medicine.

Readthrough-Promoting Drugs Gentamicin and PTC124 Fail to Rescue Nav1.5 Function of Human-Induced Pluripotent Stem Cell–Derived Cardiomyocytes Carrying Nonsense Mutations in the Sodium Channel Gene SCN5A

C. Mummery, C. Bezzina, A. Wilde, 2016, Circulation. Arrhythmia and electrophysiology.

Next-Generation Sequencing in Post-mortem Genetic Testing of Young Sudden Cardiac Death Cases

E. Behr, N. Lahrouchi, C. Bezzina, 2016, Front. Cardiovasc. Med..

Variant Intronic Enhancer Controls SCN10A-short Expression and Heart Conduction

C. Bezzina, K. van Duijvenboden, V. Christoffels, 2021, Circulation.

Variants in the SCN5A Promoter Associated With Various Arrhythmia Phenotypes

R. Redon, Toshihiro Tanaka, T. Tsunoda, 2016, Journal of the American Heart Association.

Role of Rare and Common Genetic Variation in SCN5A in Cardiac Electrical Function and Arrhythmia

J. Barc, C. Bezzina, 2014 .

Functional NaV1.8 Channels in Intracardiac Neurons: The Link Between SCN10A and Cardiac Electrophysiology

B. de Jonge, B. Scicluna, C. Bezzina, 2012, Circulation research.

Integrative Physiology Functional NaV1.8 Channels in Intracardiac Neurons

B. de Jonge, B. Scicluna, C. Bezzina, 2012 .

Risk of Sudden Infant Death Syndrome Among Siblings of Children Who Died of Sudden Infant Death Syndrome in Denmark

E. Behr, C. Torp‐Pedersen, G. Gislason, 2023, JAMA network open.

Rare variants in KDR, encoding VEGF Receptor 2, are associated with tetralogy of Fallot

H. Mefford, I. Thiffault, T. Pastinen, 2021, Genetics in Medicine.

Exploring the Relationship Between Schizophrenia and Cardiovascular Disease: A Genetic Correlation and Multivariable Mendelian Randomization Study

M. Munafo, D. Denys, A. Abdellaoui, 2021, medRxiv.

Impact of Selection Bias on Estimation of Subsequent Event Risk

P. Deloukas, T. Lehtimäki, D. Gudbjartsson, 2017, Circulation. Cardiovascular genetics.

A Complex Double Deletion in LMNA Underlies Progressive Cardiac Conduction Disease, Atrial Arrhythmias, and Sudden Death

L. Jordaens, Y. Pinto, R. L. Lekanne Deprez, 2011, Circulation. Cardiovascular genetics.

Sudden Cardiac Arrest and Rare Genetic Variants in the Community

A. Wilde, H. Tan, M. P. van den Berg, 2016, Circulation. Cardiovascular genetics.

Seasonality of ventricular fibrillation at first myocardial infarction and association with viral exposure

C. Torp‐Pedersen, L. Køber, T. Gerds, 2020, PloS one.

Chapter 3 The role of renin-angiotensin-aldosterone system polymorphisms in phenotypic expression of MYBPC 3-related hypertrophic cardiomyopathy

A. Wilde, C. Bezzina, M. Tanck, 2012 .

A Mutation in CALM 1 Encoding Calmodulin in Familial Idiopathic Ventricular Fibrillation in Childhood and Adolescence

J. Barc, C. Bezzina, A. Wilde, 2022 .

GNB5 Mutations Cause an Autosomal-Recessive Multisystem Syndrome with Sinus Bradycardia and Cognitive Disability.

Nicolas Guex, Arthur A M Wilde, Alexandre Reymond, 2016, American journal of human genetics.

GNB5 Mutations Cause an Autosomal-Recessive Multisystem Syndrome with Sinus Bradycardia and Cognitive Disability.

Nicolas Guex, Arthur A M Wilde, Alexandre Reymond, 2016, American journal of human genetics.

Right Ventricular Fibrosis and Conduction Delay in a Patient With Clinical Signs of Brugada Syndrome: A Combined Electrophysiological, Genetic, Histopathologic, and Computational Study

Simona Casini, Ruben Coronel, Arthur A M Wilde, 2005, Circulation.

Electrophysiological Abnormalities in VLCAD Deficient hiPSC-Cardiomyocytes Do not Improve with Carnitine Supplementation

S. Ferdinandusse, R. Wanders, R. Houtkooper, 2021, Frontiers in Pharmacology.

Contribution of Sodium Channel Mutations to Bradycardia and Sinus Node Dysfunction in LQT3 Families

A. Wilde, R. Wilders, C. Bezzina, 2003, Circulation research.

G Enetic Control of Sodium Channel Function Inherited Arrhythmia Syndromes That Arise from Aberrant Na

H. Tan, C. Bezzina, A. Wilde, 2003 .

Heart failure following STEMI: a contemporary cohort study of incidence and prognostic factors

Johannes M. I. H. Gho, P. Postema, F. Asselbergs, 2017, Open Heart.

HCN4 mutations in multiple families with bradycardia and left ventricular noncompaction cardiomyopathy.

R. Redon, Y. Pinto, A. Wilde, 2014, Journal of the American College of Cardiology.

Common and rare susceptibility genetic variants predisposing to Brugada Syndrome in Thailand.

T. Meitinger, K. Nademanee, W. Wongcharoen, 2020, Heart rhythm.

Identification of an INa-dependent and Ito-mediated proarrhythmic mechanism in cardiomyocytes derived from pluripotent stem cells of a Brugada syndrome patient

G. Bett, S. Cook, C. Ching, 2018, Scientific Reports.

Common genetic variation and risk for sudden cardiac death in acquired cardiac disease.

C. Bezzina, 2014, Heart rhythm.

Genetic predisposition for sudden cardiac death in myocardial ischaemia: the Arrhythmia Genetics in the NEtherlandS study

A. Wilde, C. Bezzina, R. Marsman, 2011, Netherlands heart journal : monthly journal of the Netherlands Society of Cardiology and the Netherlands Heart Foundation.

The molecular genetics of arrhythmias.

D. Roden, C. Bezzina, A. Wilde, 2005, Cardiovascular research.

Yield and Pitfalls of Ajmaline Testing in the Evaluation of Unexplained Cardiac Arrest and Sudden Unexplained Death: Single-Center Experience With 482 Families.

Yolan J. Reckman, A. Wilde, P. Postema, 2017, JACC. Clinical electrophysiology.

Clinical Characteristics of SCN5A p.R965C Carriers: A Common Founder Variant Predisposing to Brugada Syndrome in Thailand.

K. Nademanee, W. Wongcharoen, T. Ngarmukos, 2021, Circulation. Genomic and precision medicine.

Maturation of hiPSC-derived cardiomyocytes promotes adult alternative splicing of SCN5A and reveals changes in sodium current associated with cardiac arrhythmia

C. Mummery, H. Mei, L. Yiangou, 2022, Cardiovascular research.

Overlap Syndrome of Cardiac Sodium Channel Disease in Mice Carrying the Equivalent Mutation of Human SCN5A-1795insD

P. Carmeliet, H. Tan, A. V. van Ginneken, 2006, Circulation.

Possible Bradycardic Mode of Death and Successful Pacemaker Treatment in a Large Family with Features of Long QT Syndrome Type 3 and Brugada Syndrome

A. Wilde, H. Crijns, J. Cornel, 2001, Journal of cardiovascular electrophysiology.

Early repolarization pattern: its ECG characteristics, arrhythmogeneity and heritability

C. Bezzina, Y. Mizusawa, 2014, Journal of Interventional Cardiac Electrophysiology.

Haplotype-sharing analysis implicates chromosome 7q36 harboring DPP6 in familial idiopathic ventricular fibrillation.

P. Postema, K. Zeppenfeld, K. Koch, 2009, American journal of human genetics.

Genetics of lone atrial fibrillation.

T. Koopmann, C. Bezzina, 2010, Europace : European pacing, arrhythmias, and cardiac electrophysiology : journal of the working groups on cardiac pacing, arrhythmias, and cardiac cellular electrophysiology of the European Society of Cardiology.

SCN5A Mutation Type and a Genetic Risk Score Associate Variably With Brugada Syndrome Phenotype in SCN5A Families

R. Redon, E. Behr, T. Meitinger, 2020, Circulation. Genomic and precision medicine.

Common Sodium Channel Promoter Haplotype in Asian Subjects Underlies Variability in Cardiac Conduction

D. Roden, W. Shimizu, A. Wilde, 2006, Circulation.

Supraventricular tachycardias, conduction disease, and cardiomyopathy in 3 families with the same rare variant in TNNI3K (p.Glu768Lys).

A. Wilde, Hanlin Gao, D. Tester, 2019, Heart rhythm.

MicroRNAs in cardiac diseases : The devil is in the details

Yolan J. Reckman, E. Creemers, H. Tan, 2013 .

Clinical Aspects of Type 3 Long-QT Syndrome: An International Multicenter Study.

Jørgen K. Kanters, E. Kaufman, A. Moss, 2016, Circulation.

Sequential Defects in Cardiac Lineage Commitment and Maturation Cause Hypoplastic Left Heart Syndrome

R. Lange, M. Mann, T. Meitinger, 2021, bioRxiv.

Reduced Sodium Channel Function Unmasks Residual Embryonic Slow Conduction in the Adult Right Ventricular Outflow Tract

R. Coronel, C. Bezzina, V. Christoffels, 2013, Circulation research.

Genetic variation in GNB5 causes bradycardia by increasing IK,ACh augmenting cholinergic response.

R. Wilders, C. Bezzina, A. Verkerk, 2019, Disease models & mechanisms.

Genetic variation in GNB5 causes bradycardia by augmenting the cholinergic response via increased acetylcholine-activated potassium current (IK,ACh)

R. Wilders, C. Bezzina, A. Verkerk, 2019, Disease Models & Mechanisms.

Genetic correction of the W156X mutation in a patient- specific hiPSC line carrying compound heterozygous mutations in the SCN5A gene

C. Mummery, C. Bezzina, Richard P. Davis, 2017 .

A Heterozygous Deletion Mutation in the Cardiac Sodium Channel Gene SCN5A with Loss- and Gain-of-Function Characteristics Manifests as Isolated Conduction Disease, without Signs of Brugada or Long QT Syndrome

L. Eckardt, E. Schulze-Bahr, M. Paul, 2013, PloS one.

Compound Heterozygosity for Mutations (W156X and R225W) in SCN5A Associated With Severe Cardiac Conduction Disturbances and Degenerative Changes in the Conduction System

Lucas J Herfst, H. Jongsma, C. Bezzina, 2003, Circulation research.

Genomic organisation and chromosomal localisation of two members of the KCND ion channel family, KCND2 and KCND3

A. Moorman, A. Wilde, C. Bezzina, 2000, Human Genetics.

Combined reduction of intercellular coupling and membrane excitability differentially affects transverse and longitudinal cardiac conduction.

Jacques M T de Bakker, Harold V M van Rijen, R. Hauer, 2009, Cardiovascular research.

Unique Cardiac Purkinje Fiber Transient Outward Current &bgr;-Subunit Composition: A Potential Molecular Link to Idiopathic Ventricular Fibrillation

L. Jordaens, A. Wilde, P. Postema, 2013, Circulation research.

Genomic approaches for the elucidation of genes and gene networks underlying cardiovascular traits

C. Bezzina, M. Adriaens, 2018, Biophysical Reviews.

Predicting cardiac electrical response to sodium-channel blockade and Brugada syndrome using polygenic risk scores

T. Meitinger, A. Wilde, P. Postema, 2019, European heart journal.

Polymorphisms in the cardiac sodium channel promoter displaying variant in vitro expression activity

D. Roden, A. Pfeufer, A. Wilde, 2008, European Journal of Human Genetics.

Exome sequencing identifies primary carnitine deficiency in a family with cardiomyopathy and sudden death

N. Lahrouchi, C. Bezzina, A. Postma, 2017, European Journal of Human Genetics.

Inherited Cardiac Arrhythmia Syndromes: Role of the Sodium Channel

C. Bezzina, A. Wilde, R. Marsman, 2011 .

Unique Cardiac Purkinje Fiber Transient Outward Current β-Subunit CompositionNovelty and Significance

L. Jordaens, A. Wilde, P. Postema, 2013 .

Potential Molecular Link to Idiopathic Ventricular Fibrillation-Subunit Composition : A β Unique Cardiac Purkinje Fiber Transient Outward Current

L. Jordaens, A. Wilde, P. Postema, 2013 .

Evaluation of polygenic score for hypertrophic cardiomyopathy in the general population and across clinical settings

D. O’Regan, Wenjia Bai, A. Marvao, 2023, medRxiv.

Cardiac Conduction Common Sodium Channel Promoter Haplotype in Asian Subjects Underlies Variability in

D. Roden, W. Shimizu, Ping Yang, 2006 .

Gating-Dependent Mechanisms for Flecainide Action in SCN5A-Linked Arrhythmia Syndromes

P. C. Viswanathan, D. Roden, J. Balser, 2001, Circulation.

Associations of schizophrenia with arrhythmic disorders and electrocardiogram traits: an in-depth genetic exploration of population samples

D. Smit, D. Denys, J. Treur, 2023, medRxiv.

Genome-wide association studies of cardiovascular disease.

J. Erdmann, C. Bezzina, R. Walsh, 2023, Physiological reviews.

Chronically elevated branched chain amino acid levels are pro-arrhythmic

C. Gieger, A. Peters, M. Müller-Nurasyid, 2021, Cardiovascular Research.

Arrhythmogenic right ventricular cardiomyopathy: growing evidence for complex inheritance.

C. Bezzina, Elisabeth M. Lodder, 2013, Circulation. Cardiovascular genetics.

The yield of postmortem genetic testing in sudden death cases with structural findings at autopsy

J. Skinner, E. Behr, M. Sheppard, 2019, European Journal of Human Genetics.

Functional Consequences of the SCN5A-p.Y1977N Mutation within the PY Ubiquitylation Motif: Discrepancy between HEK293 Cells and Transgenic Mice

W. Chung, C. Bezzina, C. Remme, 2019, International journal of molecular sciences.

Abstract 16031: Tnni3k is a Novel Modulator of Cardiac Conduction

D. Marchuk, P. Moerland, B. Scicluna, 2011 .

PDZ-domain-binding motif regulates cardiomyocyte compartment-specific Na V 1.5 channel expression and function regulation via motif in

R. Redon, Diana Shy, J. Barc, 2014 .

Founder mutations in the Netherlands

P. Postema, N. Hofman, C. Bezzina, 2009, Netherlands heart journal : monthly journal of the Netherlands Society of Cardiology and the Netherlands Heart Foundation.

Founder mutations in the Netherlands: familial idiopathic ventricular fibrillation and DPP6

A. Wilde, P. Postema, K. Zeppenfeld, 2011, Netherlands heart journal : monthly journal of the Netherlands Society of Cardiology and the Netherlands Heart Foundation.

Sudden cardiac arrest associated with use of a non-cardiac drug that reduces cardiac excitability: evidence from bench, bedside, and community.

H. Tan, A. Bardai, C. Bezzina, 2013, European heart journal.

Subcellular trafficking of ATP-sensitive potassium channel subunits Kir6.1 and Kir6.2

C. Bezzina, 2009 .

Correction: Seasonality of ventricular fibrillation at first myocardial infarction and association with viral exposure

L. Køber, T. Gerds, S. Midgley, 2020, PloS one.

Novelties in Brugada Syndrome: Complex Genetics, Risk Stratification, and Catheter Ablation.

P. Postema, C. Bezzina, A. Wilde, 2023, Cardiac electrophysiology clinics.

Genetic Burden of TNNI3K in Diagnostic Testing of Patients With Dilated Cardiomyopathy and Supraventricular Arrhythmias

P. Ellinor, S. Choi, S. Lubitz, 2023, Circulation. Genomic and precision medicine.

Genetic association study of QT interval highlights role for calcium signaling pathways in myocardial repolarization

Andrew D. Johnson, Thomas W. Mühleisen, M. Nalls, 2014, Nature Genetics.

2023 ESC Guidelines for the management of cardiomyopathies.

B. Lewis, L. Fauchier, L. Neubeck, 2023, European heart journal.

Subtle killers and sudden death: Genetic variants modulating ventricular fibrillation in the setting of myocardial infarction

R. Pazoki, C. Bezzina, M. Tanck, 2015 .

A Comprehensive Evaluation of the Genetic Architecture of Sudden Cardiac Arrest

O. Franco, T. Lumley, J. Rioux, 2017, bioRxiv.

Genetics of cardiomyopathy and channelopathy

C. Bezzina, 2008 .

Genotype-phenotype dilemma in a case of sudden cardiac death with the E1053K mutation and a deletion in the SCN5A gene.

A. Wilde, S. Kääb, B. Beckmann, 2017, Forensic science international.

Understanding cardiac electrical phenotypes in the genomic era

D. Marchuk, P. Moerland, B. Scicluna, 2015 .

Diagnostic Value of Flecainide Testing in Unmasking SCN5A‐Related Brugada Syndrome

J. Ruijter, H. Tan, N. Hofman, 2006, Journal of cardiovascular electrophysiology.

Functional modulation of atrio-ventricular conduction by enhanced late sodium current and calcium-dependent mechanisms in Scn5a1798insD/+ mice

I. van der Made, E. Creemers, G. Thiene, 2020, Europace.

Understanding cardiac electrical phenotypes in the genomic era

A. Wilde, P. Lichtner, T. Koopmann, 2015 .

Abstract 5675: Brugada-Type ST Segment Elevation after Sodium Channel Blockade is Caused by Right Ventricular Excitation Failure in Discontinuous Myocardium

R. Coronel, M. Potse, A. Linnenbank, 2008 .

Arrhythmogenic cardiomyopathy : pathology , genetics , and concepts in pathogenesis CHAPTER 2

D. Judge, C. Basso, C. Bezzina, 2019 .

Gene-centric meta-analysis in 87,736 individuals of European ancestry identifies multiple blood-pressure-related loci.

Tom R. Gaunt, Andrew D. Johnson, Tom S. Price, 2014, American journal of human genetics.

Animal models and animal-free innovations for cardiovascular research: current status and routes to be explored. Consensus document of the ESC working group on myocardial function and the ESC Working Group on Cellular Biology of the Heart.

B. Rosenhahn, U. Schotten, R. Passier, 2022, Cardiovascular research.

Ion Channel Disease as a Cause of the Brugada Syndrome

C. Bezzina, A. Wilde, 2003 .

10 Ion Channel Disease as a Cause of the Brugada Syndrome Molecular and Genetic Aspects

C. Bezzina, A. Wilde, 2003 .

Quantitative trait loci for electrocardiographic parameters and arrhythmia in the mouse.

R. Coronel, B. Scicluna, C. Bezzina, 2011, Journal of Molecular and Cellular Cardiology.

Sodium channel (dys)function and cardiac arrhythmias.

C. Bezzina, C. Remme, 2010, Cardiovascular therapeutics.

Dilated cardiomyopathy due to sodium channel dysfunction: what is the connection?

C. Bezzina, C. Remme, 2008, Circulation. Arrhythmia and electrophysiology.

Cardiac Sodium Channel Overlap Syndromes: Different Faces of SCN5A

C. Bezzina, Vasc Biol, L. Steinman, 2008 .

Genetically Determined Differences in Sodium Current Characteristics Modulate Conduction Disease Severity in Mice With Cardiac Sodium Channelopathy

R. Houlgatte, H. Tan, J. D. de Bakker, 2009, Circulation research.

Common and Rare Variant Contributions to Bradyarrhythmias from Multi-Ancestry Meta-Analyses

K. Lunetta, H. May, P. Ellinor, 2023, medRxiv.

Type of SCN5A mutation determines clinical severity and degree of conduction slowing in loss-of-function sodium channelopathies.

H. Tan, F. Sacher, V. Probst, 2009, Heart rhythm.

Clinical Aspects of Type 3 Long-QT Syndrome: An International Multicenter Study.

Derick R. Peterson, Jørgen K. Kanters, E. Kaufman, 2016, Circulation.

clinical aspects of type 3 long-Qt syndrome an international Multicenter study