A. Naito

发表

Cardiomyocyte gene programs encoding morphological and functional signatures in cardiac hypertrophy and failure

H. Aburatani, I. Komuro, S. Nomura, 2018, Nature Communications.

Angiogenesis and Cardiac Hypertrophy: Maintenance of Cardiac Function and Causative Roles in Heart Failure

I. Komuro, H. Akazawa, A. Naito, 2014, Circulation research.

Notch activation mediates angiotensin II-induced vascular remodeling by promoting the proliferation and migration of vascular smooth muscle cells

I. Komuro, T. Minamino, Kaoru Ito, 2013, Hypertension Research.

Wnt signaling and aging-related heart disorders.

Issei Komuro, I. Komuro, I. Shiojima, 2010, Circulation research.

Changes of electrocardiogram and hemodynamics in response to dipyridamole: In vivo comparative analyses using anesthetized beagle dogs and microminipigs.

A. Naito, A. Sugiyama, Kentaro Ando, 2018, Journal of pharmacological sciences.

Gremlin Enhances the Determined Path to Cardiomyogenesis

Akihiro Umezawa, Kenji Matsumoto, Hatsune Makino, 2008, PloS one.

Corrigendum: IGFBP-4 is an inhibitor of canonical Wnt signalling required for cardiogenesis

I. Komuro, I. Shiojima, Yuzuru Ito, 2014, Nature.

IGFBP-4 is an inhibitor of canonical Wnt signalling required for cardiogenesis

I. Komuro, I. Shiojima, Yuzuru Ito, 2008, Nature.

Generation of Fabry cardiomyopathy model for drug screening using induced pluripotent stem cell-derived cardiomyocytes from a female Fabry patient.

H. Tojo, I. Komuro, Y. Sakata, 2018, Journal of molecular and cellular cardiology.

Leukemia Inhibitory Factor Enhances Endogenous Cardiomyocyte Regeneration after Myocardial Infarction

A. Iwama, I. Komuro, H. Akazawa, 2016, PloS one.

Aging of the immune system and chronic inflammation

A. Naito, 2015 .

Phenotypic Screening Using Patient-Derived Induced Pluripotent Stem Cells Identified Pyr3 as a Candidate Compound for the Treatment of Infantile Hypertrophic Cardiomyopathy.

I. Komuro, I. Shiojima, S. Nomura, 2018, International heart journal.

Comparison of electropharmacological effects between terfenadine and its active derivative fexofenadine using a cross-over study in halothane-anesthetized dogs to analyze variability of pharmacodynamic and pharmacokinetic profiles of terfenadine and torsadogenic risk of fexofenadine.

A. Naito, A. Sugiyama, Kentaro Ando, 2018, The Journal of toxicological sciences.

Activation of DNA Damage Response and Cellular Senescence in Cardiac Fibroblasts Limit Cardiac Fibrosis After Myocardial Infarction.

I. Komuro, Yuki Masumura, S. Hikoso, 2019, International heart journal.

Calpain-dependent Cleavage of N-cadherin Is Involved in the Progression of Post-myocardial Infarction Remodeling*

I. Komuro, Y. Sakata, Kaoru Ito, 2014, The Journal of Biological Chemistry.

Electropharmacological effects of intracellular Ca2+ handling modulator caldaret on the heart assessed in the halothane-anesthetized dogs.

A. Naito, A. Sugiyama, Kentaro Ando, 2019, Journal of pharmacological sciences.

DNA single-strand break-induced DNA damage response causes heart failure

I. Komuro, I. Shiojima, S. Nomura, 2017, Nature Communications.

Wnt/&bgr;-Catenin Signaling Contributes to Skeletal Myopathy in Heart Failure via Direct Interaction With Forkhead Box O

I. Komuro, I. Shiojima, S. Nomura, 2015, Circulation. Heart failure.

Sunitinib does not acutely alter left ventricular systolic function, but induces diastolic dysfunction

A. Naito, A. Sugiyama, Kentaro Ando, 2018, Cancer Chemotherapy and Pharmacology.

Activation of endothelial β-catenin signaling induces heart failure

T. Noda, I. Komuro, I. Shiojima, 2016, Scientific Reports.

Discovery of a Small Molecule to Increase Cardiomyocytes and Protect the Heart After Ischemic Injury

H. Aburatani, Y. Hata, I. Komuro, 2018, JACC. Basic to translational science.

Pressure Overload Impairs Cardiac Function in Long-Chain Fatty Acid Transporter CD36-Knockout Mice.

S. Yamashita, I. Komuro, Y. Sakata, 2019, International heart journal.

Angiotensin II receptor blockade promotes repair of skeletal muscle through down-regulation of aging-promoting C1q expression

I. Komuro, Y. Sakata, H. Akazawa, 2015, Scientific Reports.

Agonist-Independent Constitutive Activity of Angiotensin II Receptor Promotes Cardiac Remodeling in Mice

I. Komuro, I. Shiojima, S. Umemura, 2012, Hypertension.

Anti-In fl ammatory Peptides From Cardiac Progenitors Ameliorate Dysfunction After Myocardial Infarction

I. Komuro, Yoshio Kobayashi, M. Kanda, 2014 .

Anti‐Inflammatory Peptides From Cardiac Progenitors Ameliorate Dysfunction After Myocardial Infarction

I. Komuro, Yoshio Kobayashi, M. Kanda, 2014, Journal of the American Heart Association.

Monocyte-derived extracellular Nampt-dependent biosynthesis of NAD+ protects the heart against pressure overload

I. Komuro, Y. Sakata, H. Akazawa, 2015, Scientific Reports.

Pirfenidone exhibits cardioprotective effects by regulating myocardial fibrosis and vascular permeability in pressure-overloaded hearts.

I. Komuro, Y. Sakata, H. Akazawa, 2015, American journal of physiology. Heart and circulatory physiology.

In vivo characterization of rate-dependent impact on the QT interval of microminipig assessed by atrial electrical pacing: Development of correction formulae of QT interval

A. Naito, A. Sugiyama, Koki Chiba, 2019, The Journal of veterinary medical science.

Development of correction formula for field potential duration of human induced pluripotent stem cell-derived cardiomyocytes sheets.

Y. Sekino, A. Naito, Y. Kanda, 2017, Journal of Pharmacological Sciences.

Dasatinib can Impair Left Ventricular Mechanical Function But May Lack Proarrhythmic Effect: A Proposal of Non-clinical Guidance for Predicting Clinical Cardiovascular Adverse Events of Tyrosine Kinase Inhibitors

A. Naito, Y. Kanda, Masachika Fujiyoshi, 2019, Cardiovascular Toxicology.

Sensitivity and Reliability of Halothane‐anaesthetized Microminipigs to Assess Risk of Drug‐induced Long QT Syndrome

A. Naito, A. Sugiyama, Kentaro Ando, 2017, Basic & clinical pharmacology & toxicology.

Experimental analysis of the onset mechanism of TdP reported in an LQT3 patient during pharmacological treatment with serotonin–dopamine antagonists against insomnia and nocturnal delirium

A. Naito, A. Sugiyama, Koki Chiba, 2019, Heart and Vessels.

Generation of Induced Pluripotent Stem Cells From Patients With Duchenne Muscular Dystrophy and Their Induction to Cardiomyocytes.

I. Komuro, Y. Sakata, Toshihiro Yamaguchi, 2016, International heart journal.

Characterization of microminipig as a laboratory animal for safety pharmacology study by analyzing fluvoxamine-induced cardiovascular and dermatological adverse reactions

A. Naito, A. Sugiyama, Koki Chiba, 2019, Cardiovascular Toxicology.

Analysis of proarrhythmic potential of an atypical antipsychotic drug paliperidone in the halothane-anesthetized dogs.

Koichiro Tanaka, A. Naito, A. Sugiyama, 2017, Journal of pharmacological sciences.

Characterization of a small molecule that promotes cell cycle activation of human induced pluripotent stem cell-derived cardiomyocytes.

Y. Hata, I. Komuro, S. Nomura, 2019, Journal of molecular and cellular cardiology.

Mathematical Modeling and Transcriptome Profiling of Breast Cancer Cells During Tamoxifen Treatment Reveal Multiple Trajectories for Resistant Subtypes

A. Naito, S. Magi, Mariko Okada, 2021 .

Myocardial energy provision is preserved by increased utilization of glucose and ketone bodies in CD36 knockout mice.

S. Yamashita, T. Watabe, M. Imaizumi, 2015, Metabolism: clinical and experimental.

Amitriptyline May Have Possibility to Induce Brugada Syndrome Rather than Long QT Syndrome

A. Naito, A. Sugiyama, Kentaro Ando, 2017, Cardiovascular Toxicology.

Analysis of electro-mechanical relationship in human iPS cell-derived cardiomyocytes sheets under proarrhythmic condition assessed by simultaneous field potential and motion vector recordings.

A. Naito, Y. Kanda, A. Sugiyama, 2019, Journal of pharmacological sciences.

Complement C1q Activates Canonical Wnt Signaling and Promotes Aging-Related Phenotypes

I. Komuro, I. Shiojima, S. Nomura, 2012, Cell.

A crucial role of a high mobility group protein HMGA2 in cardiogenesis

Y. Hiroi, I. Komuro, I. Shiojima, 2008, Nature Cell Biology.

Increase of sensitivity to mechanical stimulus after transplantation of murine induced pluripotent stem cell-derived astrocytes in a rat spinal cord injury model.

Kazuhisa Takahashi, A. Naito, Atsushi Murata, 2011, Journal of neurosurgery. Spine.

A combination approach of pseudotime analysis and mathematical modeling for understanding drug-resistant mechanisms

Elisa Domínguez-Hüttinger, A. Naito, S. Magi, 2021, Scientific Reports.

Novel Therapeutic Targets and Strategies against Myocardial Diseases

I. Komuro, I. Shiojima, A. Naito, 2012 .

Promotion of CHIP-Mediated p53 Degradation Protects the Heart From Ischemic Injury

I. Komuro, I. Shiojima, S. Nomura, 2010, Circulation research.

Complement C1q-induced activation of β-catenin signalling causes hypertensive arterial remodelling

T. Noda, I. Komuro, I. Shiojima, 2015, Nature Communications.

Activated β-Catenin in Foxp3+ Regulatory T cells Links Inflammatory Environments to Autoimmunity

T. Noda, I. Komuro, D. Hafler, 2018, Nature Immunology.

PTGER2-β-Catenin Axis Links High Salt Environments to Autoimmunity by Balancing IFNγ and IL-10 in FoxP3+ Regulatory T cells

T. Noda, I. Komuro, D. Hafler, 2018, bioRxiv.

Wnt Signaling in Cardiogenesis

I. Komuro, I. Shiojima, S. Nomura, 2013 .

Cardiac side population cells have a potential to migrate and differentiate into cardiomyocytes in vitro and in vivo

I. Komuro, A. Uezumi, H. Akazawa, 2007, The Journal of cell biology.

Developmental stage-specific biphasic roles of Wnt/β-catenin signaling in cardiomyogenesis and hematopoiesis

I. Komuro, I. Shiojima, K. Hidaka, 2006, Proceedings of the National Academy of Sciences.

Dysbiosis and compositional alterations with aging in the gut microbiota of patients with heart failure

M. Hattori, K. Honda, H. Morita, 2017, PloS one.

An EP4 Receptor Agonist Inhibits Cardiac Fibrosis Through Activation of PKA Signaling in Hypertrophied Heart.

I. Komuro, Y. Sakata, H. Akazawa, 2017, International heart journal.

Phosphatidylinositol 3-Kinase–Akt Pathway Plays a Critical Role in Early Cardiomyogenesis by Regulating Canonical Wnt Signaling

Hiroyuki Aburatani, Hiroyuki Takano, Hiroshi Akazawa, 2005, Circulation research.

Activated β-Catenin in Foxp3+ Regulatory T cells Links Inflammatory Environments to Autoimmunity

T. Noda, I. Komuro, D. Hafler, 2018, Nature Immunology.

High-throughput single-molecule RNA imaging analysis reveals heterogeneous responses of cardiomyocytes to hemodynamic overload.

H. Aburatani, I. Komuro, S. Nomura, 2019, Journal of molecular and cellular cardiology.

Early stage-specific inhibitions of cardiomyocyte differentiation and expression of Csx/Nkx-2.5 and GATA-4 by phosphatidylinositol 3-kinase inhibitor LY294002.

Isao Shiraishi, Tetsuro Takamatsu, Issei Komuro, 2003, Experimental cell research.

A. Naito, Y. Kanda, Masachika Fujiyoshi, 2019, Cardiovascular Toxicology.

Regeneration of the Cardiac Conduction System by Adipose Tissue-Derived Stem Cells.

I. Komuro, Yoshio Kobayashi, M. Kanda, 2015, Circulation journal : official journal of the Japanese Circulation Society.

Cardiac dopamine D1 receptor triggers ventricular arrhythmia in chronic heart failure

I. Komuro, K. Yoshimi, S. Nomura, 2020, Nature Communications.

Genetic basis of cardiomyopathy and the genotypes involved in prognosis and left ventricular reverse remodeling

H. Aburatani, N. Hagiwara, I. Komuro, 2018, Scientific Reports.

Genetic basis of cardiomyopathy and the genotypes involved in prognosis and left ventricular reverse remodeling

H. Aburatani, N. Hagiwara, I. Komuro, 2018, Scientific Reports.

Wnt Signaling in Cardiogenesis : Atsuhiko T. Naito, Seitaro Nomura, Ichiro Shiojima and Issei Komuro*

I. Shiojima, S. Nomura, A. Naito, 2013 .

Steroid-responsive thromboangiitis obliterans

I. Komuro, T. Minamino, A. Naito, 2004, The Lancet.

In vivo Analysis of the Anti-atrial Fibrillatory, Proarrhythmic and Cardiodepressive Profiles of Dronedarone as a Guide for Safety Pharmacological Evaluation of Antiarrhythmic Drugs

H. Yamazaki, A. Naito, A. Sugiyama, 2018, Cardiovascular Toxicology.

In vivo Analysis of the Anti-atrial Fibrillatory, Proarrhythmic and Cardiodepressive Profiles of Dronedarone as a Guide for Safety Pharmacological Evaluation of Antiarrhythmic Drugs

A. Naito, Kentaro Ando, Yuji Nakamura, 2017, Cardiovascular Toxicology.

Decreased YAP activity reduces proliferative ability in human induced pluripotent stem cell of duchenne muscular dystrophy derived cardiomyocytes

I. Komuro, K. Hidaka, S. Hikoso, 2021, Scientific Reports.

Excitation propagation in three-dimensional engineered hearts using decellularized extracellular matrix.

J. Nakai, I. Komuro, Y. Sakata, 2014, Biomaterials.

Analysis of Safety Margin of Lithium Carbonate Against Cardiovascular Adverse Events Assessed in the Halothane-Anesthetized Dogs

A. Naito, A. Sugiyama, Kentaro Ando, 2018, Cardiovascular Toxicology.

Analysis of Safety Margin of Lithium Carbonate Against Cardiovascular Adverse Events Assessed in the Halothane-Anesthetized Dogs

A. Naito, Kentaro Ando, Yuji Nakamura, 2018, Cardiovascular Toxicology.

Implantation of cardiac progenitor cells using self-assembling peptide improves cardiac function after myocardial infarction.

I. Komuro, M. Kanda, A. Naito, 2010, Journal of molecular and cellular cardiology.

Complement C1q Activates Canonical Wnt Signaling and Promotes Aging-Related Phenotypes

I. Komuro, I. Shiojima, T. Minamino, 2012, Cell.

Measurement of J–Tpeakc along with QT-Interval Prolongation May Increase the Assay Sensitivity and Specificity for Predicting the Onset of Drug-Induced Torsade de Pointes: Experimental Evidences Based on Proarrhythmia Model Animals

A. Naito, Y. Kanda, A. Sugiyama, 2019, Cardiovascular Toxicology.

A. Naito, Y. Kanda, Koki Chiba, 2019, Cardiovascular Toxicology.

Dysbiosis and compositional alterations with aging in the gut microbiota of patients with heart failure

M. Hattori, K. Honda, H. Morita, 2017, PloS one.

Optimizing the Direction and Order of the Motion Unveiled the Ability of Conventional Monolayers of Human Induced Pluripotent Stem Cell-Derived Cardiomyocytes to Show Frequency-Dependent Enhancement of Contraction and Relaxation Motion

A. Naito, Y. Kanda, A. Sugiyama, 2020, Frontiers in Cell and Developmental Biology.

Characterization of microminipig as a laboratory animal for safety pharmacology study by analyzing fluvoxamine-induced cardiovascular and dermatological adverse reactions

A. Naito, A. Sugiyama, Koki Chiba, 2019, Cardiovascular Toxicology.

Angiogenesis and Cardiac Hypertrophy: Maintenance of Cardiac Function and Causative Roles in Heart Failure

I. Komuro, H. Akazawa, A. Naito, 2014, Circulation research.

Analysis of torsadogenic and pharmacokinetic profile of E-4031 in dogs bridging the gap of information between in vitro proarrhythmia assay and clinical observation in human subjects.

A. Naito, A. Sugiyama, Kentaro Ando, 2018, Journal of pharmacological sciences.

Cardiac side population cells have a potential to migrate and differentiate into cardiomyocytes in vitro and in vivo

I. Komuro, A. Uezumi, H. Akazawa, 2007, The Journal of cell biology.

Use of microminipigs for unveiling unknown mechanisms of azithromycin-induced cardiovascular death.

A. Naito, A. Sugiyama, Kentaro Ando, 2018, Journal of pharmacological sciences.

Electropharmacological characterization of microminipigs as a laboratory animal using anti-influenza virus drug oseltamivir.

A. Naito, A. Sugiyama, Kentaro Ando, 2018, The Journal of toxicological sciences.