P. García de Frutos

发表

Axl expression is increased in early stages of left ventricular remodeling in an animal model with pressure-overload

M. Sitges, M. Batlle, N. Castillo, 2019, PloS one.

Expression of the vitamin K-dependent proteins GAS6 and protein S and the TAM receptor tyrosine kinases in human atherosclerotic carotid plaques

J. Krupiński, P. García de Frutos, X. Muñoz, 2011, Thrombosis and Haemostasis.

Gas6 promotes inflammation by enhancing interactions between endothelial cells, platelets, and leukocytes.

P. Carmeliet, M. Daemen, B. Dahlbäck, 2008, Blood.

A Functional Role of GAS6/TAM in Nonalcoholic Steatohepatitis Progression Implicates AXL as Therapeutic Target

J. Lorens, A. Colell, Helena Cristóbal, 2019, Cellular and molecular gastroenterology and hepatology.

Use of serum levels of high sensitivity troponin T, galectin-3 and C-terminal propeptide of type I procollagen at long term follow-up in heart failure patients with reduced ejection fraction: Comparison with soluble AXL and BNP.

M. Farrero, M. Castel, M. Sabaté, 2016, International journal of cardiology.

Regorafenib Alteration of the BCL-xL/MCL-1 Ratio Provides a Therapeutic Opportunity for BH3-Mimetics in Hepatocellular Carcinoma Models

J. Bruix, L. Boix, A. Colell, 2020, Cancers.

Genetic aspects of thrombotic disease

P. García de Frutos, Bengt Zöller, 2015, Thrombosis and Haemostasis.

Role of sodium tungstate as a potential antiplatelet agent

M. Díaz-Ricart, Carolina Caballo, G. Escolar, 2015, Drug design, development and therapy.

Antioxidants Threaten Multikinase Inhibitor Efficacy against Liver Cancer by Blocking Mitochondrial Reactive Oxygen Species

A. Colell, P. García de Frutos, M. Marí, 2021, Antioxidants.

Electrochemical immunosensing of Growth arrest‐specific 6 in human plasma and tumor cell secretomes

S. Campuzano, J. Pingarrón, P. García de Frutos, 2021, Electrochemical Science Advances.

Coagulation factor and protease pathways in thrombosis and cardiovascular disease

H. ten Cate, P. García de Frutos, T. Hackeng, 2017, Thrombosis and Haemostasis.

Mechanisms of thrombophilia.

P. García de Frutos, 2007, Thrombosis and haemostasis.

The Second Laminin G-type Domain of Protein S Is Indispensable for Expression of Full Cofactor Activity in Activated Protein C-catalysed Inactivation of Factor Va and Factor VIIIa

B. Dahlbäck, G. Nicolaes, P. García de Frutos, 2000, Thrombosis and Haemostasis.

The SHBG‐like region of protein S is crucial for factor V‐dependent APC‐cofactor function

B. Dahlbäck, P. García de Frutos, Petra Nyberg, 1998, FEBS letters.

An electrochemical immunosensor for brain natriuretic peptide prepared with screen-printed carbon electrodes nanostructured with gold nanoparticles grafted through aryl diazonium salt chemistry.

S. Campuzano, P. Yáñez‐Sedeño, J. Pingarrón, 2018, Talanta.

Growth arrest-specific gene 6 (GAS6)

P. García de Frutos, L. Bellido-Martín, Laura Fernández-Fernández, 2008, Thrombosis and Haemostasis.

Serum levels of Growth Arrest-Specific 6 protein and soluble AXL in patients with ST-segment elevation myocardial infarction

R. Perea, Helena Cristóbal, P. García de Frutos, 2019, European heart journal. Acute cardiovascular care.

A Common 4G Allele in the Promoter of the Plasminogen Activator Inhibitor-1 (PAI-1) Gene as a Risk Factor for Pulmonary Embolism and Arterial Thrombosis in Hereditary Protein S Deficiency

B. Dahlbäck, P. García de Frutos, Bengt Zöller, 1998, Thrombosis and Haemostasis.

Growth arrest–specific protein 6 is hepatoprotective against murine ischemia/reperfusion injury

P. García de Frutos, M. Marí, J. Fernandez-Checa, 2010, Hepatology.

High-Sensitivity Troponin T and Soluble Form of AXL as Long-Term Prognostic Biomarkers after Heart Transplantation

P. García de Frutos, J. Ordóñez‐Llanos, J. Cinca, 2018, Disease markers.

Growth Arrest-Specific Factor 6 (GAS6) Is Increased in COVID-19 Patients and Predicts Clinical Outcome

G. Nicolaes, Helena Cristóbal, P. García de Frutos, 2021, Biomedicines.

Impaired Antibody Response Is Associated with Histone-Release, Organ Dysfunction and Mortality in Critically Ill COVID-19 Patients

K. Ekdahl, G. Nicolaes, A. Bergqvist, 2022, Journal of clinical medicine.

Direct actions of dapagliflozin and interactions with LCZ696 and spironolactone on cardiac fibroblasts of patients with heart failure and reduced ejection fraction

E. Ortega, S. Brugaletta, M. Sabaté, 2022, ESC heart failure.

Electrochemical Immunosensing of ST2: A Checkpoint Target in Cancer Diseases

S. Campuzano, J. Pingarrón, P. García de Frutos, 2021, Biosensors.

Comparative evaluation of the performance of electrochemical immunosensors using magnetic microparticles and nanoparticles. Application to the determination of tyrosine kinase receptor AXL

S. Campuzano, P. Yáñez‐Sedeño, J. Pingarrón, 2017, Microchimica Acta.

Molecular basis of protein S deficiency

P. García de Frutos, N. Sala, P. Fuentes-Prior, 2007, Thrombosis and Haemostasis.

SHBG region of the anticoagulant cofactor protein S: Secondary structure prediction, circular dichroism spectroscopy, and analysis of naturally occurring mutations

P. Fernlund, B. Dahlbäck, B. Villoutreix, 1997, Proteins.

Thrombophilia as a multigenic disease.

B. Dahlbäck, P. García de Frutos, Bengt Zöller, 1999, Haematologica.

Resistance to activated protein C as an additional genetic risk factor in hereditary deficiency of protein S.

B. Dahlbäck, P. García de Frutos, Bengt Zöller, 1995, Blood.

Role of Vitamin K-Dependent Factors Protein S and GAS6 and TAM Receptors in SARS-CoV-2 Infection and COVID-19-Associated Immunothrombosis

G. Nicolaes, P. García de Frutos, M. Marí, 2020, Cells.

Nonanticoagulant heparin prevents histone-mediated cytotoxicity in vitro and improves survival in sepsis.

H. Hemker, O. Soehnlein, G. Nicolaes, 2014, Blood.

The α7β0 Isoform of the Complement Regulator C4b-Binding Protein Induces a Semimature, Anti-Inflammatory State in Dendritic Cells

A. Blom, F. Borràs, S. Rodríguez de Córdoba, 2013, The Journal of Immunology.

Histone H3 Cleavage in Severe COVID-19 ICU Patients

C. Reutelingsperger, K. Wichapong, G. Nicolaes, 2021, Frontiers in Cellular and Infection Microbiology.

Stimulation of Sky tyrosine phosphorylation by bovine protein S--domains involved in the receptor-ligand interaction.

P. García de Frutos, X. He, B. Dahlback, 1997, European journal of biochemistry.

Structural investigation of C4b‐binding protein by molecular modeling: Localization of putative binding sites

D. Covell, A. Wallqvist, B. Dahlbäck, 1998, Proteins.

6-phosphofructo 2-kinase/fructose 2,6-bisphosphatase in liver of the teleost Sparus aurata.

P. García de Frutos, I. Baanante, 1994, Archives of biochemistry and biophysics.

Fructose 2,6-bisphosphate in liver of Sparus aurata: influence of nutritional state.

P. García de Frutos, I. Baanante, F. Fernández, 1990, Comparative biochemistry and physiology. B, Comparative biochemistry.

Differential regulation of alpha and beta chains of C4b-binding protein during acute-phase response resulting in stable plasma levels of free anticoagulant protein S.

B. Dahlbäck, P. García de Frutos, Bengt Zöller, 1994, Blood.

Clarification of the Risk for Venous Thrombosis Associated with Hereditary Protein S Deficiency by Investigation of a Large Kindred with a Characterized Gene Defect

B. Dahlbäck, P. García de Frutos, D. Lane, 1998, Annals of Internal Medicine.

Evaluation of the relationship between protein S and C4b-binding protein isoforms in hereditary protein S deficiency demonstrating type I and type III deficiencies to be phenotypic variants of the same genetic disease.

B. Dahlbäck, P. García de Frutos, Bengt Zöller, 1995, Blood.

Functional characterization of twelve natural PROS1 mutations associated with anticoagulant protein S deficiency

P. García de Frutos, Gemma Navarro, M. C. Mulero, 2008, Haematologica.

Both G-type domains of protein S are required for the high-affinity interaction with C4b-binding protein.

B. Dahlbäck, S. Linse, P. García de Frutos, 1999, European journal of biochemistry.

Whole-exome sequencing in evaluation of patients with venous thromboembolism.

J. Huntington, Eun-Ju Lee, A. Leavitt, 2017, Blood advances.

Thrombocytopenia-associated mutations in Ser/Thr kinase MASTL deregulate actin cytoskeletal dynamics in platelets

M. Malumbres, M. Trakala, P. García de Frutos, 2018, The Journal of clinical investigation.

AXL receptor tyrosine kinase is increased in patients with heart failure.

M. Farrero, M. Castel, M. Batlle, 2014, International journal of cardiology.

Hepatocellular Carcinoma: Molecular Pathogenesis and Therapeutic Advances

A. Colell, P. García de Frutos, M. Marí, 2022, Cancers.

Melatonin induces mechanisms of brain resilience against neurodegeneration

M. Pallàs, P. García de Frutos, C. Sanfeliu, 2018, Journal of pineal research.

Soluble AXL is a novel blood marker for early detection of pancreatic ductal adenocarcinoma and differential diagnosis from chronic pancreatitis

A. Carrato, C. Guerra, Helena Cristóbal, 2021, EBioMedicine.

Interaction between serum amyloid P component and C4b-binding protein associated with inhibition of factor I-mediated C4b degradation.

B. Dahlbäck, P. García de Frutos, 1994, Journal of immunology.

Cells in Cardiovascular Disease: Using Diversity to Confront Adversity

P. García de Frutos, J. Martínez-González, 2020, Cells.

Protein S deficiency and novel oral anticoagulants: an intriguing case.

P. García de Frutos, D. Tàssies, 2014, Thrombosis research.

Genetic and clinical data reinforce the role of GAS6 and TAM receptors in liver fibrosis.

P. García de Frutos, M. Marí, A. Morales, 2016, Journal of Hepatology.

Prognostic Value of Soluble AXL in Serum from Heart Failure Patients with Preserved and Reduced Left Ventricular Ejection Fraction

M. Farrero, M. Sabaté, M. Batlle, 2023, Journal of personalized medicine.

cDNA structure of rabbit C4b-binding protein alpha-chain. Preserved sequence motive in complement regulatory protein modules which bind C4b.

B. Dahlbäck, P. García de Frutos, P. G. D. Frutos, 1995, Biochimica et biophysica acta.

Genetic aspects of thrombotic disease

P. García de Frutos, Bengt Zöller, 2015, Thrombosis and Haemostasis.

Atherosclerotic plaque development in mice is enhanced by myeloid ZEB1 downregulation

P. García de Frutos, J. Escolà-Gil, F. Díaz-Crespo, 2023, Nature communications.

Thrombophilia as a multigenic disease

B. Dahlbäck, P. García de Frutos, Bengt Zöller, 1998 .