B. Leiting

发表

Inhibition of Human Caspases by Peptide-based and Macromolecular Inhibitors*

N. Thornberry, M. Garcia-Calvo, E. Peterson, 1998, The Journal of Biological Chemistry.

(2R)-4-oxo-4-[3-(trifluoromethyl)-5,6-dihydro[1,2,4]triazolo[4,3-a]pyrazin-7(8H)-yl]-1-(2,4,5-trifluorophenyl)butan-2-amine: a potent, orally active dipeptidyl peptidase IV inhibitor for the treatment of type 2 diabetes.

G. Scapin, N. Thornberry, R. S. Roy, 2005, Journal of medicinal chemistry.

Crystal structure of Escherichia coli UDPMurNAc-tripeptide d-alanyl-d-alanine-adding enzyme (MurF) at 2.3 A resolution.

S. Munshi, J. Chrzas, B. Leiting, 2000, Journal of molecular biology.

High-level expression of soluble protein in Escherichia coli using a His6-tag and maltose-binding-protein double-affinity fusion system.

B. Leiting, B Leiting, K. Pryor, 1997, Protein expression and purification.

Discovery of potent and selective phenylalanine based dipeptidyl peptidase IV inhibitors.

You-Jung Park, N. Thornberry, B. Leiting, 2004, Bioorganic & medicinal chemistry letters.

Discovery of potent and selective orally bioavailable beta-substituted phenylalanine derived dipeptidyl peptidase IV inhibitors.

Joseph L Duffy, Aleksandr Petrov, N. Thornberry, 2005, Bioorganic & medicinal chemistry letters.

Fluoroolefins as amide bond mimics in dipeptidyl peptidase IV inhibitors.

G. Scapin, N. Thornberry, B. Leiting, 2008, Bioorganic & medicinal chemistry letters.

Potent and selective proline derived dipeptidyl peptidase IV inhibitors.

N. Thornberry, B. Leiting, Sanjeev Kumar, 2004, Bioorganic & medicinal chemistry letters.

Fluoropyrrolidine amides as dipeptidyl peptidase IV inhibitors.

Ping Chen, N. Thornberry, B. Leiting, 2004, Bioorganic & medicinal chemistry letters.

4-Amino cyclohexylglycine analogues as potent dipeptidyl peptidase IV inhibitors.

Aleksandr Petrov, N. Thornberry, B. Leiting, 2004, Bioorganic & medicinal chemistry letters.

Discovery of potent, selective, and orally bioavailable pyridone-based dipeptidyl peptidase-4 inhibitors.

Aleksandr Petrov, N. Thornberry, B. Leiting, 2006, Bioorganic & medicinal chemistry letters.

(2S,3S)-3-Amino-4-(3,3-difluoropyrrolidin-1-yl)-N,N-dimethyl-4-oxo-2-(4-[1,2,4]triazolo[1,5-a]-pyridin-6-ylphenyl)butanamide: a selective alpha-amino amide dipeptidyl peptidase IV inhibitor for the treatment of type 2 diabetes.

G. Scapin, N. Thornberry, R. S. Roy, 2006, Journal of medicinal chemistry.

The ble gene of Streptoalloteichus hindustanus as a new selectable marker for Dictyostelium discoideum confers resistance to phleomycin.

B. Leiting, A. Noegel, Angelika A. Noegel, 1991, Biochemical and biophysical research communications.

(3R)-4-[(3R)-3-Amino-4-(2,4,5-trifluorophenyl)butanoyl]-3-(2,2,2-trifluoroethyl)-1,4-diazepan-2-one, a selective dipeptidyl peptidase IV inhibitor for the treatment of type 2 diabetes.

G. Scapin, Suresh B. Singh, N. Thornberry, 2007, Bioorganic & medicinal chemistry letters.

Dipeptidyl peptidase IV inhibitors derived from beta-aminoacylpiperidines bearing a fused thiazole, oxazole, isoxazole, or pyrazole.

N. Thornberry, B. Leiting, Huaibing He, 2005, Bioorganic & medicinal chemistry letters.

Triazolopiperazine-amides as dipeptidyl peptidase IV inhibitors: close analogs of JANUVIA (sitagliptin phosphate).

N. Thornberry, B. Leiting, Dooseop Kim, 2007, Bioorganic & medicinal chemistry letters.

Optimization of 1,4-diazepan-2-one containing dipeptidyl peptidase IV inhibitors for the treatment of type 2 diabetes.

N. Thornberry, B. Leiting, G. Eiermann, 2007, Bioorganic & medicinal chemistry letters.

Inhibition of Dipeptidyl-Peptidase IV Does Not Increase Circulating IGF-1 Concentrations in Growing Pigs

B. Leiting, G. Hickey, K. Pryor, 2006, Experimental biology and medicine.

Diastereoselective synthesis and configuration-dependent activity of (3-substituted-cycloalkyl)glycine pyrrolidides and thiazolidides as dipeptidyl peptidase IV inhibitors.

N. Thornberry, B. Leiting, F. Marsilio, 2004, Bioorganic & medicinal chemistry letters.

Expression and characterization of protein geranylgeranyltransferase type I from the pathogenic yeast Candida albicans and identification of yeast selective enzyme inhibitors.

B. Leiting, J. Williamson, P. Mazur, 2000, Biochimica et biophysica acta.

Fluoropyrrolidine amides as dipeptidyl peptidase IV inhibitors.

Ping Chen, N. Thornberry, B. Leiting, 2004, Bioorganic & medicinal chemistry letters.

The NMR solution structure of the non-classical homeodomain from the rat liver LFB1/HNF1 transcription factor.

G. Wider, M. Billeter, K. Wüthrich, 1997, Journal of molecular biology.

The three‐dimensional NMR‐solution structure of the polypeptide fragment 195–286 of the LFB1/HNF1 transcription factor from rat liver comprises a nonclassical homeodomain.

K. Wüthrich, R. Cortese, G. Otting, 1993, The EMBO journal.

Purification, crystallization and preliminary X-ray analysis of Escherichia coli UDP-N-acetylmuramoyl:L-alanine ligase (MurC).

E. Baker, B. Leiting, Clyde A. Smith, 2003, Acta crystallographica. Section D, Biological crystallography.

Imidazopiperidine amides as dipeptidyl peptidase IV inhibitors for the treatment of diabetes.

Ping Chen, N. Thornberry, B. Leiting, 2007, Bioorganic & medicinal chemistry letters.

Inhibition of IMP-1 metallo-beta-lactamase and sensitization of IMP-1-producing bacteria by thioester derivatives.

B. Leiting, D. Pompliano, J. Balkovec, 1999, FEMS microbiology letters.

Discovery of 3-aminopiperidines as potent, selective, and orally bioavailable dipeptidyl peptidase IV inhibitors.

N. Thornberry, B. Leiting, S. Xu, 2007, Bioorganic & medicinal chemistry letters.

Design, synthesis, and biological evaluation of triazolopiperazine-based beta-amino amides as potent, orally active dipeptidyl peptidase IV (DPP-4) inhibitors.

G. Scapin, N. Thornberry, B. Leiting, 2007, Bioorganic & medicinal chemistry letters.

Dipeptidyl peptidase IV inhibition for the treatment of type 2 diabetes: potential importance of selectivity over dipeptidyl peptidases 8 and 9.

A. Woods, D. Zaller, N. Thornberry, 2005, Diabetes.

Biological roles of actin-binding proteins in Dictyostelium discoideum examined using genetic techniques.

A. Noegel, M. Schleicher, H. Hartmann, 1989, Cell motility and the cytoskeleton.

Discovery of potent and selective dipeptidyl peptidase IV inhibitors derived from beta-aminoamides bearing subsituted triazolopiperazines.

G. Scapin, N. Thornberry, R. S. Roy, 2008, Journal of medicinal chemistry.

Catalytic properties and inhibition of proline-specific dipeptidyl peptidases II, IV and VII.

C. Craik, N. Thornberry, R. Cummings, 2003, The Biochemical journal.

Synthesis and Application of Fmoc-O-[Bis(dimethylamino)phosphono]tyrosine, a Versatile Protected Phosphotyrosine Equivalent

A. Burkhardt, J. Bolen, B. Leiting, 1995 .

A high quality nuclear magnetic resonance solution structure of peptide deformylase from Escherichia coli: Application of an automated assignment strategy using GARANT

B. Leiting, S. Grant, John F. O'Connell, 1999, Journal of biomolecular NMR.

The NMR Solution Structure of the Non-classical Homeodomain from the Rat Liver LFB 1 / HNF 1 Transcription Factor

G. Wider, M. Billeter, B. Leiting, 1997 .

ENGINEERING A CELL-FREE MUREIN BIOSYNTHETIC PATHWAY : COMBINATORIAL ENZYMOLOGY IN DRUG DISCOVERY

Kenny K. Wong, B. Leiting, D. Pompliano, 1998 .

Kinetic investigation of human dipeptidyl peptidase II (DPPII)-mediated hydrolysis of dipeptide derivatives and its identification as quiescent cell proline dipeptidase (QPP)/dipeptidyl peptidase 7 (DPP7).

A. Lambeir, I. De Meester, B. Leiting, 2005, The Biochemical journal.

Crystallization and preliminary X-ray analysis of the Escherichia coli UDP-MurNAc-tripeptide D-alanyl-D-alanine-adding enzyme (MurF).

S. Munshi, Y. Li, B. Leiting, 1999, Acta crystallographica. Section D, Biological crystallography.

Support of1H NMR assignments in proteins by biosynthetically directed fractional13C-labeling

K. Wüthrich, T. Szyperski, D. Neri, 1992 .

Support of 1H NMR assignments in proteins by biosynthetically directed fractional 13C-labeling.

K. Wüthrich, T. Szyperski, D. Neri, 1992, Journal of biomolecular NMR.

The extrachromosomal replication of Dictyostelium plasmid Ddp2 requires a cis-acting element and a plasmid-encoded trans-acting factor

B. Leiting, I. Lindner, A. Noegel, 1990, Molecular and cellular biology.

Construction of an extrachromosomally replicating transformation vector for Dictyostelium discoideum.

B. Leiting, A. Noegel, 1988, Plasmid.

Substituted piperazines as novel dipeptidyl peptidase IV inhibitors.

N. Thornberry, B. Leiting, Huaibing He, 2004, Bioorganic & medicinal chemistry letters.

Discovery of new binding elements in DPP-4 inhibition and their applications in novel DPP-4 inhibitor design.

G. Scapin, Suresh B. Singh, N. Thornberry, 2008, Bioorganic & medicinal chemistry letters.

Soluble penicillin-binding protein 2a: beta-lactam binding and inhibition by non-beta-lactams using a 96-well format.

B. Leiting, D. Pompliano, K. Pryor, 1998, Analytical Biochemistry.

Soluble Penicillin-Binding Protein 2a: β-Lactam Binding and Inhibition by Non-β-Lactams Using a 96-Well Format

B. Leiting, D. Pompliano, Joseph K. Wu, 1998 .

4-aminophenylalanine and 4-aminocyclohexylalanine derivatives as potent, selective, and orally bioavailable inhibitors of dipeptidyl peptidase IV.

Joseph L Duffy, G. Scapin, N. Thornberry, 2007, Bioorganic & medicinal chemistry letters.

Discovery of potent, selective, and orally bioavailable oxadiazole-based dipeptidyl peptidase IV inhibitors.

G. Scapin, N. Thornberry, B. Leiting, 2006, Bioorganic & medicinal chemistry letters.

4-arylcyclohexylalanine analogs as potent, selective, and orally active inhibitors of dipeptidyl peptidase IV.

Joseph L Duffy, G. Scapin, N. Thornberry, 2007, Bioorganic & medicinal chemistry letters.

Potent and selective proline derived dipeptidyl peptidase IV inhibitors.

N. Thornberry, B. Leiting, Sanjeev Kumar, 2004, Bioorganic & Medicinal Chemistry Letters.

WITHDRAWN: Reprint of: High-Level Expression of Soluble Protein in Escherichia coli Using a His 6 -Tag and Maltose-Binding-Protein Double-Affinity Fusion System

B. Leiting, K. Pryor, 2011 .

One-day enzymatic synthesis and purification of UDP-N- [1-14C]acetyl-glucosamine.

B. Leiting, M. Anderson, S. Eveland, 1998, Analytical biochemistry.

Predictable deuteration of recombinant proteins expressed in Escherichia coli.

B. Leiting, F. Marsilio, John F. O'Connell, 1998, Analytical biochemistry.

Discovery of potent and selective dipeptidyl peptidase IV inhibitors derived from beta-aminoamides bearing subsituted triazolopiperazines.

G. Scapin, N. Thornberry, R. S. Roy, 2008, Journal of medicinal chemistry.