D. Brömme

J. Delaissé, K. Søe, D. Brömme, 2017, Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research.

Structural basis of collagen fiber degradation by cathepsin K

G. Brayer, N. Nguyen, Xin Du, 2014, Proceedings of the National Academy of Sciences.

Bone Remodeling: Cathepsin K in Collagen Turnover

D. Brömme, 2012 .

Structure-Activity Analysis of Cathepsin K/Chondroitin 4-Sulfate Interactions*

M. James, D. Brömme, F. Lecaille, 2010, The Journal of Biological Chemistry.

Substrate Profiling of Cysteine Proteases Using a Combinatorial Peptide Library Identifies Functionally Unique Specificities*

Francesco Leonetti, Jonathan A. Ellman, Charles S. Craik, 2006, Journal of Biological Chemistry.

S3 to S3' subsite specificity of recombinant human cathepsin K and development of selective internally quenched fluorescent substrates.

L. Juliano, M. Juliano, D. Brömme, 2003, The Biochemical journal.

Regulation of Collagenase Activities of Human Cathepsins by Glycosaminoglycans*

M. Bogyo, G. Fields, R. Gordon, 2004, Journal of Biological Chemistry.

Evidence that serpin architecture intrinsically supports papain-like cysteine protease inhibition: engineering alpha(1)-antitrypsin to inhibit cathepsin proteases.

J. Whisstock, J. Irving, S. Bottomley, 2002, Biochemistry.

The serpin SQN-5 is a dual mechanistic-class inhibitor of serine and cysteine proteinases.

J. Whisstock, J. Irving, David Miller, 2002, Biochemistry.

Cathepsin K Activity-dependent Regulation of Osteoclast Actin Ring Formation and Bone Resorption*

C. Peters, P. Saftig, D. Brömme, 2009, Journal of Biological Chemistry.

The amplified mouse squamous cell carcinoma antigen gene locus contains a serpin (Serpinb3b) that inhibits both papain-like cysteine and trypsin-like serine proteinases.

D. Brömme, G. Silverman, C. Luke, 2004, Genomics.

Inhibition of LDL-oxidation and antioxidant properties related to polyphenol content of hydrophilic fractions from seaweed Halimeda Incrassata (Ellis) Lamouroux

D. Brömme, A. Vázquez, J. mancini‐filho, 2012 .

Inhibition of cathepsin K with lysosomotropic macromolecular inhibitors.

J. Kopeček, D. Brömme, P. Kopec̆ková, 2002, Biochemistry.

Functional Expression of Recombinant Proteases

D. Brömme, B. Schmidt, 1999 .

Classical and Neonatal Marfan Syndrome Mutations in Fibrillin-1 Cause Differential Protease Susceptibilities and Protein Function*

G. Iyengar, D. Reinhardt, D. Brömme, 2011, The Journal of Biological Chemistry.

Structural requirements for the collagenase and elastase activity of cathepsin K and its selective inhibition by an exosite inhibitor.

C. Craik, D. Brömme, Rafael V. C. Guido, 2015, The Biochemical journal.

An Intracellular Serpin Regulates Necrosis by Inhibiting the Induction and Sequelae of Lysosomal Injury

Simon C Watkins, D. Stolz, G. Moulder, 2007, Cell.

Human bleomycin hydrolase: molecular cloning, sequencing, functional expression, and enzymatic characterization.

D. Payan, D. Anderson, D. Brömme, 1996, Biochemistry.

The specificity of the S1' subsite of cysteine proteases

R. Ménard, Y. Konishi, D. Brömme, 1993, FEBS letters.

Role of Cysteine Cathepsins in Extracellular Proteolysis

D. Brömme, Susan Wilson, S. Wilson, 2011 .

Cloning, characterization, and expression of the human TIN-ag-RP gene encoding a novel putative extracellular matrix protein.

B. Levy, D. Brömme, H. Wex, 2000, Biochemical and biophysical research communications.

Human cathepsins F and W: A new subgroup of cathepsins.

B. Levy, D. Brömme, H. Wex, 1999, Biochemical and biophysical research communications.

Inhibitory Activity of a Heterochromatin-associated Serpin (MENT) against Papain-like Cysteine Proteinases Affects Chromatin Structure and Blocks Cell Proliferation*

J. Whisstock, J. Irving, S. Bottomley, 2002, The Journal of Biological Chemistry.

Human cathepsin W, a putative cysteine protease predominantly expressed in CD8+ T‐lymphocytes

D. Brömme, C. Linnevers, S. Smeekens, 1997, FEBS letters.

Comparative substrate specificity analysis of recombinant human cathepsin V and cathepsin L.

L. Juliano, M. Juliano, D. Brömme, 2004, Archives of biochemistry and biophysics.

Cathepsin V, a Novel and Potent Elastolytic Activity Expressed in Activated Macrophages*

Matthew Bogyo, M. Bogyo, D. Brömme, 2004, Journal of Biological Chemistry.

Selective Inhibition of the Collagenase Activity of Cathepsin K*

J. Selent, D. Brömme, G. Lalmanach, 2007, Journal of Biological Chemistry.

Characterization of novel cathepsin K mutations in the pro and mature polypeptide regions causing pycnodysostosis.

H. Weinstein, B. Gelb, D. Rimoin, 1999, The Journal of clinical investigation.

Biochemical properties and regulation of cathepsin K activity.

D. Brömme, G. Lalmanach, F. Lecaille, 2008, Biochimie.

The role of cathepsins in osteoporosis and arthritis: rationale for the design of new therapeutics.

D. Brömme, Dieter Brömme, Yoshiyuki Yasuda, 2005, Advanced drug delivery reviews.

The propeptide of cruzipain − a potent selective inhibitor of the trypanosomal enzymes cruzipain and brucipain, and of the human enzyme cathepsin F

R. Ménard, T. Sulea, J. Scharfstein, 2007, The FEBS journal.

Cathepsin K in thyroid epithelial cells: sequence, localization and possible function in extracellular proteolysis of thyroglobulin.

V. Herzog, D. Brömme, K. Brix, 2000, Journal of cell science.

High level expression and crystallization of recombinant human cathepsin S

M. Mcgrath, D. Brömme, 1996, Protein science : a publication of the Protein Society.

Green asymmetric synthesis of epoxypeptidomimetics and evaluation as human cathepsin K inhibitors.

D. Brömme, J. Fernandes, A. Corrêa, 2020, Bioorganic & medicinal chemistry.

Fructus Ligustri Lucidi preserves bone quality through the regulation of gut microbiota diversity, oxidative stress, TMAO and Sirt6 levels in aging mice

A. Orekhov, D. Brömme, Dongwei Zhang, 2019, Aging.

Corrigendum: Antioxidant Effect of Fructus Ligustri Lucidi Aqueous Extract in Ovariectomized Rats Is Mediated through Nox4-ROS-NF-κB Pathway

D. Brömme, Dongwei Zhang, J. Niu, 2017, Front. Pharmacol..

Comparative study of the pharmacokinetic parameters for salidroside in normal and estrogen-deficient female rats after oral administration of an aqueous extract of Fructus Ligustri Lucidi using a validated ultra-performance liquid chromatography mass spectrometry/mass spectrometry method

A. Orekhov, Ming Niu, D. Brömme, 2020 .

Identification of mouse cathepsin K structural elements that regulate the potency of odanacatib.

G. Brayer, N. Nguyen, D. Brömme, 2017, The Biochemical journal.

Small molecule affinity fingerprinting. A tool for enzyme family subclassification, target identification, and inhibitor design.

Irwin D Kuntz, Samuel Toba, Matthew Bogyo, 2002, Chemistry & biology.

Human cathepsin F: expression in baculovirus system, characterization and inhibition by protein inhibitors

V. Turk, D. Brömme, B. Turk, 2004, Biological chemistry.

Expression of cathepsin K in lung epithelial cells.

T. Welte, D. Brömme, T. Köhnlein, 1999, American journal of respiratory cell and molecular biology.

Expression, Purification and Characterization of Hexahistidine- Tagged Human Cathepsin K in High Five Cells

K. Mitsudo, T. Shellenberger, M. Frederick, 2015 .

Acridone alkaloids as potent inhibitors of cathepsin V.

D. Brömme, A. Andricopulo, R. Guido, 2011, Bioorganic & medicinal chemistry.

Azapeptides structurally based upon inhibitory sites of cystatins as potent and selective inhibitors of cysteine proteases.

S. Ołdziej, D. Brömme, M. Abrahamson, 2002, Journal of medicinal chemistry.

Leupeptazin, a highly modified tripeptide isolated from cultures of a Streptomyces sp. inhibits cathepsin K.

David E. Williams, R. Andersen, D. Brömme, 2017, Bioorganic & medicinal chemistry letters.

Substrate specificity of thermitase, a thermostable serine proteinase fromThermoactinomyces vulgaris

D. Brömme, R. Kleine, 1984, Current Microbiology.

Synthesis of Peptidyl Ene Diones: Selective Inactivators of the Cysteine Proteinases

D. Brömme, B. Walker, S. Hawthorne, 2007, Chemical biology & drug design.

Cathepsin K expression in human lung.

T. Welte, D. Brömme, E. Weber, 2000, Advances in experimental medicine and biology.

Human Cathepsin F. Molecular Cloning, Functional Expression, Tissue Localization, and Enzymatic Characterization

H. Chapman, D. Brömme, P. M. Yao, 1998 .

Improvement of cathepsin S detection using a designed FRET peptide based on putative natural substrates

M. Juliano, D. Brömme, A. K. Carmona, 2010, Peptides.

Antimicrobial Peptide LL-37 Is Both a Substrate of Cathepsins S and K and a Selective Inhibitor of Cathepsin L.

S. Samsonov, K. Nazmi, D. Brömme, 2015, Biochemistry.

Bone innervation and vascularization regulated by osteoclasts contribute to refractive pain-related behavior in the collagen antibody-induced arthritis model

C. Svensson, P. Mehlen, T. L. Andersen, 2021, bioRxiv.

Inhibition of aminopeptidases by N-aminoacyl-O-4-nitrobenzoyl hydroxamates.

H. Kirschke, D. Brömme, H. Demuth, 1993, Biochimica et biophysica acta.

TITLE: EXTRACELLULAR MATRIX REMODELING IN ATOPIC DERMATITIS HAR- 1 NESSES THE ONSET OF AN ASTHMATIC PHENOTYPE AND IS A POTENTIAL CON-

A. Gruber, D. Beule, A. Thiel, 2022 .

Human cathepsin O2, a novel cysteine protease highly expressed in osteoclastomas and ovary molecular cloning, sequencing and tissue distribution.

D. Brömme, K. Okamoto, Kathleen Okamoto, 1995, Biological chemistry Hoppe-Seyler.

Cathepsin K inhibitor-polymer conjugates: potential drugs for the treatment of osteoporosis and rheumatoid arthritis.

J. Kopeček, D. Brömme, P. Kopec̆ková, 2004, International journal of pharmaceutics.

The Unusual Resistance of Avian Defensin AvBD7 to Proteolytic Enzymes Preserves Its Antibacterial Activity

K. Loth, V. Labas, D. Brömme, 2016, PloS one.

Elastolytic activity of cysteine cathepsins K, S, and V promotes vascular calcification

D. Brömme, Pierre-Marie Andrault, N. Mackenzie, 2019, Scientific Reports.

Pivotal role of cathepsin K in lung fibrosis.

T. Welte, P. Saftig, R. Hartig, 2004, The American journal of pathology.

Development and characterization of a eukaryotic expression system for human type II procollagen

Clara K. Chan, N. R. Forde, D. Brömme, 2015, BMC Biotechnology.

Identification of substrate-specific inhibitors of cathepsin K through high-throughput screening.

M. Roberge, Xin Du, D. Brömme, 2019, The Biochemical journal.

Thermitase - kinetic differentiation to the subtilisins.

D. Brömme, G. Jahreis, K. Peters, 1996, Advances in experimental medicine and biology.

Cathepsin K: a cysteine protease with unique kinin-degrading properties.

P. Saftig, S. Duchêne, D. Brömme, 2004, The Biochemical journal.

The S2 subsites of cathepsins K and L and their contribution to collagen degradation

E. Purisima, D. Brömme, Dieter Brömme, 2007, Protein science : a publication of the Protein Society.

Irreversible inhibition of human cathepsins B, L, S and K by hypervalent tellurium compounds

L. Juliano, D. Brömme, R. Cunha, 2009, Biological chemistry.

SERPINB11 Is a New Noninhibitory Intracellular Serpin

J. Whisstock, D. Brömme, G. Silverman, 2007, Journal of Biological Chemistry.

Evaluation of dipeptide alpha-keto-beta-aldehydes as new inhibitors of cathepsin S.

D. Brömme, B. Walker, J. Lynas, 2000, Biochemical and biophysical research communications.

Monitoring compartment-specific substrate cleavage by cathepsins B, K, L, and S at physiological pH and redox conditions

D. Turk, N. Kühl, D. Brömme, 2009 .

Tight-binding inhibition of cathepsin S by cystatins.

H. Kirschke, D. Brömme, R. Rinne, 1991, Biomedica biochimica acta.

Genomic structure, chromosomal localization, and expression of human cathepsin W.

R. Desnick, B. Levy, D. Brömme, 1998, Biochemical and biophysical research communications.

Label-Free Mass Quantitation of Individual Cathepsin K Enzymes using Interferrometric Scattering Microscopy

E. Grant, D. Brömme, Pierre-Marie Andrault, 2020 .

Human cathepsins W and F form a new subgroup of cathepsins that is evolutionary separated from the cathepsin B- and L-like cysteine proteases.

B. Levy, D. Brömme, H. Wex, 2000, Advances in experimental medicine and biology.

Molecular cloning, expression and potential functions of the human proteinase-activated receptor-2.

S. Coughlin, D. Payan, A. Connolly, 1996, The Biochemical journal.

EXTRACELLULAR MATRIX REMODELING IN ATOPIC DERMATITIS HARNESSES THE ONSET OF AN ASTHMATIC PHENOTYPE AND IS A POTENTIAL CONTRIBUTOR TO THE ATOPIC MARCH

A. Gruber, D. Beule, A. Thiel, 2022, medRxiv.

New Synthetic Quinolines as Cathepsin K Inhibitors

D. Brömme, J. Fernandes, K. D. de Oliveira, 2020 .

Contribution to activity of histidine-aromatic, amide-aromatic, and aromatic-aromatic interactions in the extended catalytic site of cysteine proteinases.

E. Purisima, P. Bonneau, D. Y. Thomas, 1996, Biochemistry.

Monitoring compartment-specific substrate cleavage by cathepsins B, K, L, and S at physiological pH and redox conditions

D. Turk, N. Kühl, D. Brömme, 2009 .

Elastin Degradation by Cathepsin V Requires Two Exosites*

C. Craik, Xin Du, D. Brömme, 2013, The Journal of Biological Chemistry.

Substrate-derived triazolo- and azapeptides as inhibitors of cathepsins K and S.

A. Delmas, D. Brömme, B. Korkmaz, 2018, European journal of medicinal chemistry.

Antimicrobial Peptide LL-37 Is Both a Substrate of Cathepsins S and K and a Selective Inhibitor of Cathepsin L.

K. Nazmi, D. Brömme, M. T. Pisabarro, 2015, Biochemistry.

The role of basic amino acid surface clusters on the collagenase activity of cathepsin K.

D. Brömme, F. Lecaille, F. S. Nallaseth, 2013, Biochemistry.

Effects of Cysteine Proteases on the Structural and Mechanical Properties of Collagen Fibers*

Hongbin Li, Xin Du, D. Brömme, 2013, The Journal of Biological Chemistry.

A Mild Inhibition of Cathepsin K Paradoxically Stimulates the Resorptive Activity of Osteoclasts in Culture

J. Delaissé, K. Søe, D. Brömme, 2018, Calcified Tissue International.

Action of rat liver cathepsin B on bradykinin and on the oxidized insulin A‐chain

H. Kirschke, D. Brömme, S. Fittkau, 1987, FEBS letters.