G. Gibson

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Mitochondrial Heterogeneity Within and Between Different Cell Types

Hsueh‐Meei Huang, C. Fowler, Hui Zhang, 2004, Neurochemical Research.

Dopaminergic cell death induced by MPP+, oxidant and specific neurotoxicants shares the common molecular mechanism

Hui Zhang, G. Gibson, L. Degiorgio, 2001, Journal of neurochemistry.

Phosphonate analogues of alpha-ketoglutarate inhibit the activity of the alpha-ketoglutarate dehydrogenase complex isolated from brain and in cultured cells.

V. Bunik, C. Thompson, G. Gibson, 2005, Biochemistry.

Enzyme-Catalyzed Side Reactions with Molecular Oxygen may Contribute to Cell Signaling and Neurodegenerative Diseases

V. Bunik, G. Gibson, Arthur J. L. Cooper, 2007, Neurochemical Research.

Mild metabolic perturbations alter succinylation of mitochondrial proteins

G. Gibson, V. Belousov, D. Bilan, 2017, Journal of neuroscience research.

Assessment of membrane potentials of mitochondrial populations in living cells.

G. Gibson, H. M. Huang, R. Carson, 2001, Analytical biochemistry.

Expression of intracellular calcium-binding proteins in cultured skin fibroblasts from Alzheimer and normal aged donors.

C. Heizmann, B. Schäfer, G. Gibson, 1994, Biochimica et biophysica acta.

Reversal of Thiamine Deficiency‐Induced Neurodegeneration

B. Volpe, G. Gibson, L. Degiorgio, 2003, Journal of neuropathology and experimental neurology.

Mitochondrial dihydrolipoyl succinyltransferase deficiency accelerates amyloid pathology and memory deficit in a transgenic mouse model of amyloid deposition.

M. Beal, G. Gibson, N. Calingasan, 2009, Free radical biology & medicine.

Effect of Decreased Oxygen on In Vitro Release of Endogenous 3,4‐Dihydroxyphenylethylamine from Mouse Striatum

G. Gibson, G. Freeman, 1986, Journal of neurochemistry.

Molecular Mechanisms of Memory and the Pathophysiology of Alzheimer's Disease

D. Alkon, G. Gibson, RENÉ ETCHEBERRIGARAY, 1994, Annals of the New York Academy of Sciences.

Diminished mitogen-induced calcium uptake by lymphocytes from alzheimer patients

J. Blass, G. Gibson, K. Sherman, 1987, Biological Psychiatry.

Benfotiamine and Cognitive Decline in Alzheimer's Disease: Results of a Randomized Placebo-Controlled Phase IIa Clinical Trial.

Y. Stern, L. Bettendorff, N. Schupf, 2020, Journal of Alzheimer's disease : JAD.

Metabolic Impairment Induces Oxidative Stress, Compromises Inflammatory Responses, and Inactivates a Key Mitochondrial Enzyme in Microglia

B. Kristal, Hui Zhang, G. Gibson, 1999, Journal of neurochemistry.

Frontal Lobe Dysfunction in Progressive Supranuclear Palsy

S. Augood, M. Beal, D. Standaert, 2000, Journal of neurochemistry.

Thiamine Deficiency: A Model of Metabolic Encephalopathy and of Selective Neuronal Vulnerability

G. Gibson, S. Karuppagounder, 2009 .

Regionally selective alterations in enzymatic activities and metabolic fluxes during thiamin deficiency

J. Blass, G. Gibson, P. Nielsen, 2004, Neurochemical Research.

Mice deficient in dihydrolipoyl succinyl transferase show increased vulnerability to mitochondrial toxins

M. Beal, Lichuan Yang, G. Gibson, 2009, Neurobiology of Disease.

Mitochondrial Aconitase is a Transglutaminase 2 Substrate: Transglutamination is a Probable Mechanism Contributing to High-Molecular-Weight Aggregates of Aconitase and Loss of Aconitase Activity in Huntington Disease Brain

M. Beal, S. Browne, J. Blass, 2005, Neurochemical Research.

Consequences of mild, graded hypoxia.

J. Blass, G. Gibson, 1979, Advances in neurology.

Human red blood cell choline uptake with age and Alzheimer's disease

J. Blass, G. Gibson, K. Sherman, 1986, Neurobiology of Aging.

Interactions of Calcium Homeostasis, Acetylcholine Metabolism, Behavior and 3,4-Diaminopyridine during Aging

G. Gibson, C. Peterson, 1986 .

Increased Inositol 1,4,5‐Trisphosphate Accumulation Correlates with an Up‐Regulation of Bradykinin Receptors in Alzheimer's Disease

G. Gibson, G. Sun, H. M. Huang, 1995, Journal of neurochemistry.

Deficits in a tricarboxylic acid cycle enzyme in brains from patients with Parkinson’s disease

A. Kingsbury, J. Blass, J. Lindsay, 2003, Neurochemistry International.

Selective linkage of mitochondrial enzymes to intracellular calcium stores differs between human induced pluripotent stem cells, neural stem cells and neurons

D. Pauli, G. Gibson, S. Noggle, 2020, bioRxiv.

Deficits in the mitochondrial enzyme α-ketoglutarate dehydrogenase lead to Alzheimer's disease-like calcium dysregulation

G. Gibson, Zuoshang Xu, T. Denton, 2012, Neurobiology of Aging.

Translocation of Amyloid Precursor Protein C-terminal Fragment(s) to the Nucleus Precedes Neuronal Death due to Thiamine Deficiency-induced Mild Impairment of Oxidative Metabolism

G. Gibson, S. Karuppagounder, L. Degiorgio, 2008, Neurochemical Research.

Selective NADH communication from α-ketoglutarate dehydrogenase to mitochondrial transhydrogenase prevents reactive oxygen species formation under reducing conditions in the heart

S. Heymans, M. Kohlhaas, C. Maack, 2020, Basic Research in Cardiology.

Monoamine Neurotransmitter Metabolism and Locomotor Activity During Chemical Hypoxia

G. Gibson, G. Freeman, P. Nielsen, 1986, Journal of neurochemistry.

Heterogeneous Expression of Transketolase in Rat Brain

F. Paoletti, G. Gibson, N. Calingasan, 1995, Journal of Neurochemistry.

Transglutaminase activity is present in highly purified nonsynaptosomal mouse brain and liver mitochondria.

J. Blass, Soo-Youl Kim, R. Ratan, 2005, Biochemistry.

Calcium stores in cultured fibroblasts and their changes with Alzheimer's disease.

L. Toral-Barza, G. Gibson, H. Zhang, 1996, Biochimica et biophysica acta.

Novel neuritic clusters with accumulations of amyloid precursor protein and amyloid precursor-like protein 2 immunoreactivity in brain regions damaged by thiamine deficiency.

J. Buxbaum, D. Price, D. Selkoe, 1996, The American journal of pathology.

Accumulation of amyloid precursor protein-like immunoreactivity in rat brain in response to thiamine deficiency

H. Wiśniewski, S. Gandy, Kwang-Soo Kim, 1995, Brain Research.

Influence of mitochondrial enzyme deficiency on adult neurogenesis in mouse models of neurodegenerative diseases

M. Beal, G. Gibson, N. Calingasan, 2008, Neuroscience.

Mitochondrial impairment in the cerebellum of the patients with progressive supranuclear palsy

M. Beal, D. S. Albers, J. Lindsay, 2001 .

The alpha-ketoglutarate dehydrogenase complex in neurodegeneration.

J. Blass, G. Gibson, N. Calingasan, 2000, Neurochemistry international.

Reduction in the E2k Subunit of the α-Ketoglutarate Dehydrogenase Complex Has Effects Independent of Complex Activity*

G. Gibson, Hui Xu, Huanlian Chen, 2005, Journal of Biological Chemistry.

Selective enrichment of cholinergic neurons with the α-ketoglutarate dehydrogenase complex in rat brain

G. Gibson, N. Calingasan, H. Baker, 1994, Neuroscience Letters.

Inhibition of the α‐ketoglutarate dehydrogenase complex by the myeloperoxidase products, hypochlorous acid and mono‐N‐chloramine

G. Gibson, T. Jeitner, Hui Xu, 2005, Journal of neurochemistry.

Tricarboxylic acid cycle enzymes following thiamine deficiency

G. Gibson, Z. Ke, P. Bubber, 2004, Neurochemistry International.

Mitochondrial Enzymes and Endoplasmic Reticulum Calcium Stores as Targets of Oxidative Stress in Neurodegenerative Diseases

Hsueh‐Meei Huang, G. Gibson, 2004, Journal of bioenergetics and biomembranes.

INHIBITION OF ACETYLCHOLINE SYNTHESIS AND OF CARBOHYDRATE UTILIZATION BY MAPLE‐SYRUP‐URINE DISEASE METABOLITES

J. Blass, G. Gibson, G. Gibson, 1976, Journal of neurochemistry.

Distribution of the α‐ketoglutarate dehydrogenase complex in rat brain

G. Gibson, N. Calingasan, H. Baker, 1994, The Journal of comparative neurology.

Immunochemical Characterization of the Deficiency of the α‐Ketoglutarate Dehydrogenase Complex in Thiamine‐Deficient Rat Brain

J. Lindsay, G. Gibson, N. Calingasan, 1998, Journal of neurochemistry.

Mitochondrial impairment in cerebellum from patients with progressive supranuclear palsy

M. Beal, D. S. Albers, G. Gibson, 2000, Neurobiology of Aging.

Inhibition of select mitochondrial enzymes in PC12 cells exposed to S-(1,1,2,2-tetrafluoroethyl)-L-cysteine.

V. Bunik, G. Gibson, Arthur J. L. Cooper, 1999, Biochemical pharmacology.

High levels of amyloid-beta protein from S182 (Glu246) familial Alzheimer's cells.

H. Wiśniewski, R. Martins, R. T. Carroll, 1995, Neuroreport.

Thiamine and Oxidants Interact to Modify Cellular Calcium Stores

Hsueh‐Meei Huang, G. Gibson, Huanlian Chen, 2010, Neurochemical Research.

Blood-Brain Barrier Abnormalities in Vulnerable Brain Regions during Thiamine Deficiency

G. Gibson, N. Calingasan, H. Baker, 1995, Experimental Neurology.

Cultures of astrocytes and microglia express interleukin 18.

T. Joh, B. Conti, G. Gibson, 1999, Brain Research. Molecular Brain Research.

Regional Acetylcholine Metabolism in Brain During Acute Hypoglycemia and Recovery

J. Ghajar, G. Gibson, T. Duffy, 1985, Journal of neurochemistry.

Cisplatin-induced toxicity is associated with platinum deposition in mouse kidney mitochondria in vivo and with selective inactivation of the alpha-ketoglutarate dehydrogenase complex in LLC-PK1 cells.

G. Gibson, Arthur J. L. Cooper, B. Krasnikov, 2006, Biochemistry.

Mild reduction in the activity of the α‐ketoglutarate dehydrogenase complex elevates GABA shunt and glycolysis

G. Gibson, U. Sonnewald, Qingli Shi, 2009, Journal of neurochemistry.

Changes in inflammatory processes associated with selective vulnerability following mild impairment of oxidative metabolism

G. Gibson, S. Karuppagounder, Hui Xu, 2007, Neurobiology of Disease.

Guidelines for the use and interpretation of assays for monitoring autophagy (4th edition)1

Mark R. Marten, Erinna F. Lee, Dana L. Miller, 2021, Autophagy.

Mitochondrial function in fibroblasts with aging in culture and/or Alzheimer's disease

Hsueh‐Meei Huang, C. Fowler, Hui Zhang, 2005, Neurobiology of Aging.

Succinylation Links Metabolism to Protein Functions

G. Gibson, Yun Yang, 2019, Neurochemical Research.

CD40–CD40L interactions promote neuronal death in a model of neurodegeneration due to mild impairment of oxidative metabolism

B. Volpe, G. Gibson, N. Calingasan, 2005, Neurochemistry International.

Dopamine, Acetylcholine, and Glutamate Interactions in Aging Behavioral and Neurochemical Correlates

G. Gibson, G. Freeman, 1988, Annals of the New York Academy of Sciences.

Oxidative stress is associated with region-specific neuronal death during thiamine deficiency.

G. Gibson, K. Uchida, N. Calingasan, 1999, Journal of neuropathology and experimental neurology.

α-KETO-ß-METHYL-n-VALERIC ACID DIMINISHES REACTIVE OXYGEN SPECIES AND ALTERS ENDOPLASMIC RETICULUM Ca2+ STORES

Hsueh‐Meei Huang, Hui Zhang, G. Gibson, 2004 .

The Cellular Basis of Delirium and Its Relevance to Age-Related Disorders Including Alzheimer's Disease

J. Blass, G. Gibson, G. Freeman, 1991, International Psychogeriatrics.

Brain dysfunction in mild to moderate hypoxia.

J. Blass, G. Gibson, W. Pulsinelli, 1981, The American journal of medicine.

Differential alteration of dopamine, acetylcholine, and glutamate release during anoxia and/or 3,4-diaminopyridine treatment

G. Gibson, G. Freeman, V. Mykytyn, 1987, Neurochemical Research.

Protection by tris(hydroxymethyl)-aminomethane against behavioral and neurochemical effects of hypoxia.

J. Blass, G. Gibson, M. Shimada, 1979, Biochemical pharmacology.

Phospholipid composition and levels are not altered in fibroblasts bearing presenilin-1 mutations

S. Rapoport, S. Sorbi, Hui Zhang, 2000, Brain Research Bulletin.

Peripheral inflammatory mechanisms modulate microglial activation in response to mild impairment of oxidative metabolism

G. Gibson, Z. Ke, William M. Bowen, 2006, Neurochemistry International.

Importance of vascular changes in selective neurodegeneration with thiamine deficiency.

S. Gandy, G. Gibson, N. Calingasan, 1997, Annals of the New York Academy of Sciences.

Impairment of behavior and acetylcholine metabolism in thiamine deficiency.

J. Blass, G. Gibson, L. Barclay, 1981, The Journal of pharmacology and experimental therapeutics.

Abnormality of a thiamine-requiring enzyme in patients with Wernicke-Korsakoff syndrome.

J. Blass, G. Gibson, 1977, The New England journal of medicine.

Abnormalities in Alzheimer’s Disease Fibroblasts Bearing the APP670/671 Mutation

D. Alkon, L. Lannfelt, M. Vestling, 1997, Neurobiology of Aging.

An in vitro model of anoxic-induced damage in mouse brain

G. Gibson, V. Mykytyn, 2004, Neurochemical Research.

Regulation of bradykinin-induced Ins(1,4,5)P3 formation by protein kinase C in human fibroblasts.

G. Gibson, H. M. Huang, H. M. Huang, 1996, Life sciences.

Selective Changes in Cell Bodies and Growth Cones of Nerve Growth Factor‐Differentiated PC12 Cells Induced by Chemical Hypoxia

L. Toral-Barza, Hui Zhang, G. Gibson, 1997, Journal of neurochemistry.

Cholinergic drugs and 4-aminopyridine alter hypoxic-induced behavioral deficits

G. Gibson, C. Peterson, C. J. Pelmas, 1983, Pharmacology Biochemistry and Behavior.

Oxidative stress increases internal calcium stores and reduces a key mitochondrial enzyme.

Hui Zhang, G. Gibson, T. Jeitner, 2002, Biochimica et biophysica acta.

Changes in cytosolic free calcium with 1,2,3,4-tetrahydro-5-aminoacridine, 4-aminopyridine and 3,4-diaminopyridine.

G. Gibson, T. Manger, 1988, Biochemical pharmacology.

Cytosolic free calcium and ATP in synaptosomes after ischemia.

L. Toral-Barza, G. Gibson, H. M. Huang, 1991, Life sciences.

Interactions of endoplasmic reticulum and mitochondria Ca2+ stores with capacitative calcium entry

Hsueh‐Meei Huang, G. Gibson, Huanlian Chen, 2014, Metabolic Brain Disease.

Abnormalities in the tricarboxylic acid (TCA) cycle in the brains of schizophrenia patients

J. Blass, V. Hartounian, G. Gibson, 2011, European Neuropsychopharmacology.

Vascular Endothelium Is a Site of Free Radical Production and Inflammation in Areas of Neuronal Loss in Thiamine‐deficient Brain

G. Gibson, N. Calingasan, NOEL Y. CALINGASAN, 2000, Annals of the New York Academy of Sciences.

Cholinergic Systems and Disorders of Carbohydrate Catabolism

J. Blass, G. Gibson, 1978 .

Oxidative Stress and Transcriptional Regulation in Alzheimer Disease

G. Gibson, Qingli Shi, 2007, Alzheimer disease and associated disorders.

Phosphatidylinositol Metabolism During In Vitro Hypoxia

Hsueh‐Meei Huang, G. Gibson, H. M. Huang, 1989, Journal of neurochemistry.

Cytosolic free calcium concentrations in synaptosomes during histotoxic hypoxia

L. Toral-Barza, Hsueh‐Meei Huang, G. Gibson, 1991, Neurochemical Research.

Neurotransmitters and Calcium During Hypoxia

L. Toral-Barza, G. Gibson, T. Manger, 1989 .

Genetic factors in Wernicke-Korsakoff syndrome.

J. Blass, G. Gibson, 1979, Alcoholism, clinical and experimental research.

Selective damage in striatum and hippocampus with in vitro anoxia

G. Gibson, G. Freeman, V. Mykytyn, 1988, Neurochemical Research.

The role of cytosolic free calcium in the regulation of pyruvate dehydrogenase in synaptosomes

L. Toral-Barza, G. Gibson, K. R. Sheu, 2004, Neurochemical Research.

The α-Ketoglutarate Dehydrogenase Complex as a Hub of Plasticity in Neurodegeneration and Regeneration

G. Gibson, Grace E. Hansen, 2022, International journal of molecular sciences.

Mitochondria and oxidative stress in neurodegenerative disorders

M. Beal, R. Ratan, G. Gibson, 2008 .

BRAIN HISTOLOGY AND BEHAVIOR OF MICE INJECTED WITH UREASE

W. J. Visek, G. Gibson, E. Richardson, 1974, Journal of neuropathology and experimental neurology.

CD40L deletion delays neuronal death in a model of neurodegeneration due to mild impairment of oxidative metabolism

B. Volpe, G. Gibson, S. Karuppagounder, 2005, Journal of Neuroimmunology.

Acetylcholine formation from glucose following acute choline supplementation

G. Gibson, K. Sherman, P. Perrino, 1991, Neurochemical Research.

Locomotor activity as a predictor of times and dosages for studies of nicotine's neurochemical actions

G. Gibson, K. Sherman, G. Freeman, 1987, Pharmacology Biochemistry and Behavior.

In vivo brain calcium homeostasis during aging

G. Dienel, G. Gibson, P. Perrino, 1986, Mechanisms of Ageing and Development.

Subsynaptosomal distribution of calcium during aging and 3,4-diaminopyridine treatment

D. Nicholls, G. Gibson, C. Peterson, 1985, Neurobiology of Aging.

Subsynaptosomal Calcium Distribution During Hypoxia and 3,4‐Diaminopyridine Treatment

D. Nicholls, G. Gibson, C. Peterson, 1985, Journal of neurochemistry.

The pyruvate dehydrogenase complex during aging

G. Gibson, C. Peterson, H. Ksiȩżak-Reding, 1984, Mechanisms of Ageing and Development.

Decreases in Amino Acid and Acetylcholine Metabolism During Hypoxia

G. Gibson, C. Peterson, J. Sansone, 1981, Journal of neurochemistry.

Alpha‐ketoglutarate dehydrogenase complex‐dependent succinylation of proteins in neurons and neuronal cell lines

S. Zhang, G. Gibson, T. Denton, 2015, Journal of neurochemistry.

Effect of age on behavioral and enzymatic changes during thiamin deficiency

G. Gibson, G. Freeman, P. Nielsen, 1987, Neurobiology of Aging.

Metabolic Impairment Elicits Brain Cell Type‐Selective Changes in Oxidative Stress and Cell Death in Culture

Hui Zhang, G. Gibson, K. Uchida, 2000, Journal of neurochemistry.

Calcium and the aging nervous system

G. Gibson, C. Peterson, 1987, Neurobiology of Aging.

Proportional inhibition of acetylcholine synthesis accompanying impairment of 3-hydroxybutyrate oxidation in rat brain slices.

J. Blass, G. Gibson, 1979, Biochemical pharmacology.

Mitochondrial abnormalities in Alzheimer brain: Mechanistic implications

Parvesh Bubber, Vahram Haroutunian, V. Haroutunian, 2005, Annals of neurology.

Cytosolic-free calcium and neurotransmitter release with decreased availability of glucose or oxygen

L. Toral-Barza, G. Gibson, T. Manger, 1989, Neurochemical Research.

Selective linkage of mitochondrial enzymes to intracellular calcium stores differs between human‐induced pluripotent stem cells, neural stem cells, and neurons

G. Gibson, S. Noggle, L. Kruger, 2020, Journal of neurochemistry.

Interactions of Mitochondria/Metabolism and Calcium Regulation in Alzheimer’s Disease: A Calcinist Point of View

G. Gibson, A. Thakkar, 2017, Neurochemical Research.

Interactions of oxidative stress with cellular calcium dynamics and glucose metabolism in Alzheimer's disease.

G. Gibson, 2002, Free radical biology & medicine.

Internal Ca2+ mobilization is altered in fibroblasts from patients with Alzheimer disease.

K. Oka, D. Alkon, G. Gibson, 1994, Proceedings of the National Academy of Sciences of the United States of America.

Potassium channel dysfunction in fibroblasts identifies patients with Alzheimer disease.

D. Alkon, K. Oka, G. Gibson, 1993, Proceedings of the National Academy of Sciences of the United States of America.

Inositol phosphates and intracellular calcium after bradykinin stimulation in fibroblasts from young, normal aged and Alzheimer donors

H. Thaler, L. Toral-Barza, G. Gibson, 1991, Neurobiology of Aging.

Interactions between inositol phosphates and cytosolic free calcium following bradykinin stimulation in cultured human skin fibroblasts.

L. Toral-Barza, G. Gibson, H. M. Huang, 1991, Biochimica et biophysica acta.

Cytosolic Free Calcium and Gene Expression During Chemical Hypoxia

L. Toral-Barza, G. Gibson, J. M. Carroll, 1992, Journal of neurochemistry.

Up‐regulation of the mitochondrial malate dehydrogenase by oxidative stress is mediated by miR‐743a

G. Gibson, Qingli Shi, 2011, Journal of neurochemistry.

Novel functions of the alpha-ketoglutarate dehydrogenase complex may mediate diverse oxidant-induced changes in mitochondrial enzymes associated with Alzheimer's disease.

G. Gibson, Hui Xu, W. Kleinman, 2008, Biochimica et biophysica acta.

Modification of endoplasmic reticulum Ca2+ stores by select oxidants produces changes reminiscent of those in cells from patients with Alzheimer disease.

Hsueh‐Meei Huang, G. Gibson, Hui Xu, 2005, Free radical biology & medicine.

MEASUREMENT OF ACETYLCHOLINE TURNOVER WITH GLUCOSE USED AS PRECURSOR: EVIDENCE FOR COMPARTMENTATION OF GLUCOSE METABOLISM IN BRAIN

D. Jenden, J. Blass, G. Gibson, 1978, Journal of neurochemistry.

Dopamine and serotonin in rat striatum duringin vivo hypoxic-hypoxia

G. Gibson, P. Broderick, 1989, Metabolic Brain Disease.

Selective alteration of mouse brain neurotransmitter release with age

G. Gibson, G. Freeman, 1987, Neurobiology of Aging.

Regional Reductions of Transketolase in Thiamine‐Deficient Rat Brain

G. Dienel, F. Paoletti, G. Gibson, 1996, Journal of neurochemistry.

Responses of the mitochondrial alpha-ketoglutarate dehydrogenase complex to thiamine deficiency may contribute to regional selective vulnerability

G. Gibson, S. Karuppagounder, Hui Xu, 2007, Neurochemistry International.

Reduced activities of thiamine-dependent enzymes in the brains and peripheral tissues of patients with Alzheimer's disease.

J. Blass, G. Gibson, K. Sheu, 1988, Archives of neurology.

Vitamin B1 (thiamine) and dementia

G. Gibson, B. Jordan, Rosanna T. Cirio, 2016, Annals of the New York Academy of Sciences.

Correlation of enzymatic, metabolic, and behavioral deficits in thiamin deficiency and its reversal

J. Blass, G. Gibson, K. Sheu, 1984, Neurochemical Research.

Studies on the Pyruvate Dehydrogenase Complex in Brain with the Arylamine Acetyltransferase‐Coupled Assay

J. Blass, G. Gibson, H. Ksiȩżak-Reding, 1982, Journal of neurochemistry.

The string test: An early behavioral change in thiamine deficiency

J. Blass, G. Gibson, L. Barclay, 1981, Pharmacology Biochemistry and Behavior.

Aging Decreases Oxidative Metabolism and the Release and Synthesis of Acetylcholine

G. Gibson, C. Peterson, 1981, Journal of neurochemistry.

A relation between (NAD+)/(NADH) potentials and glucose utilization in rat brain slices.

J. Blass, G. Gibson, G Gibson, 1976, The Journal of biological chemistry.

Metabolism and Neurotransmission

J. Blass, G. Gibson, 1983 .

Neurotransmitter and carbohydrate metabolism during aging and mild hypoxia

G. Gibson, C. Peterson, J. Sansone, 1981, Neurobiology of Aging.

Changes in Calcium Homeostasis During Aging

G. Gibson, C. Peterson, 1987 .

Decreased synthesis of acetylcholine accompanying impaired oxidation of pyruvic acid in rat brain minces.

J. Blass, R. Jope, G. Gibson, 1975, The Biochemical journal.

Induction of nitric oxide synthase and microglial responses precede selective cell death induced by chronic impairment of oxidative metabolism.

S. Gandy, G. Gibson, N. Calingasan, 1998, The American journal of pathology.

Oxidative metabolism and acetylcholine synthesis during acetylpyridine treatment

J. Blass, G. Gibson, 1985, Neurochemical Research.

Abnormal Glucose Metabolism in Alzheimer’s Disease: Relation to Autophagy/Mitophagy and Therapeutic Approaches

G. Gibson, Kalpita Banerjee, S. Munshi, 2015, Neurochemical Research.

The negative impact of α‐ketoglutarate dehydrogenase complex deficiency on matrix substrate‐level phosphorylation

M. Beal, C. Chinopoulos, G. Gibson, 2013, FASEB journal : official publication of the Federation of American Societies for Experimental Biology.

The α-ketoglutarate-dehydrogenase complex

M. Beal, J. Blass, V. Bunik, 2007, Molecular Neurobiology.

Mitochondria/metabolic reprogramming in the formation of neurons from peripheral cells: Cause or consequence and the implications to their utility

G. Gibson, A. Thakkar, 2017, Neurochemistry International.

Inhibition of α‐ketoglutarate dehydrogenase complex promotes cytochrome c release from mitochondria, caspase‐3 activation, and necrotic cell death

Hsueh‐Meei Huang, C. Fowler, G. Gibson, 2003, Journal of neuroscience research.

Inhibition of the alpha-ketoglutarate dehydrogenase complex alters mitochondrial function and cellular calcium regulation.

Hsueh‐Meei Huang, Hui Zhang, G. Gibson, 2003, Biochimica et biophysica acta.

Mild mitochondrial metabolic deficits by α-ketoglutarate dehydrogenase inhibition cause prominent changes in intracellular autophagic signaling: Potential role in the pathobiology of Alzheimer's disease

G. Gibson, Hui Xu, Kalpita Banerjee, 2016, Neurochemistry International.

Brain [U‐13C]glucose metabolism in mice with decreased α‐ketoglutarate dehydrogenase complex activity

G. Gibson, U. Sonnewald, L. Nilsen, 2011, Journal of neuroscience research.

Thiamine deficiency induces oxidative stress and exacerbates the plaque pathology in Alzheimer's mouse model

M. Beal, S. Gandy, G. Gibson, 2009, Neurobiology of Aging.

Dietary supplementation with resveratrol reduces plaque pathology in a transgenic model of Alzheimer's disease

M. Beal, G. Gibson, S. Karuppagounder, 2009, Neurochemistry International.

Inhibitors of the α‐ketoglutarate dehydrogenase complex alter [1‐13C]glucose and [U‐13C]glutamate metabolism in cerebellar granule neurons

Sónia Sá Santos, V. Bunik, C. Thompson, 2006 .

Mice deficient in dihydrolipoamide dehydrogenase show increased vulnerability to MPTP, malonate and 3‐nitropropionic acid neurotoxicity

Parvesh Bubber, M. Beal, S. Browne, 2004, Journal of neurochemistry.

Selective alteration of neurotransmitter release by low oxygen in vitro

G. Gibson, J. Hirsch, 1984, Neurochemical Research.

The RNA-binding protein HuR (Elavl1) is essential for the B cell antibody response

Tomaž Curk, Jernej Ule, Kathi Zarnack, 2015, Nature Immunology.

The role of signal transduction systems in mediating cell density dependent changes in tyrosine hydroxylase gene expression.

T. Joh, K. Kim, G. Gibson, 1995, Brain research. Molecular brain research.

Vitamin B1 (thiamine) and dementia

G. Gibson, B. Jordan, Rosanna T. Cirio, 2016, Annals of the New York Academy of Sciences.

Succinylation Links Metabolic Reductions to Amyloid and Tau Pathology

Elizabeth T. Anderson, V. Haroutunian, M. Beal, 2019 .

ALTERATIONS IN ACETYLCHOLINE SYNTHESIS AND CYCLIC NUCLEOTIDES IN MILD CEREBRAL HYPOXIA

J. Blass, G. Gibson, Masahisa Shumada, 1978, Journal of neurochemistry.

Impaired Synthesis of Acetylcholine by Mild Hypoxic Hypoxia or Nitrous Oxide

G. Gibson, T. Duffy, 1981, Journal of neurochemistry.

Phospholipid mass is increased in fibroblasts bearing the Swedish amyloid precursor mutation

L. Lannfelt, R. Cowburn, Hsueh‐Meei Huang, 2006, Brain Research Bulletin.

Cause and consequence: mitochondrial dysfunction initiates and propagates neuronal dysfunction, neuronal death and behavioral abnormalities in age-associated neurodegenerative diseases.

M. Beal, J. Blass, R. Ratan, 2010, Biochimica et biophysica acta.

University of Birmingham The RNA-binding protein HuR is essential for the B cell antibody response

Kathi, Manuel D. Díaz-Muñoz, J. Ule, 2016 .

Presenilins are enriched in endoplasmic reticulum membranes associated with mitochondria.

E. Schon, T. Bird, A. de Groof, 2009, The American journal of pathology.

Abnormal thiamine-dependent processes in Alzheimer's Disease. Lessons from diabetes

G. Gibson, B. Jordan, Rosanna T. Cirio, 2013, Molecular and Cellular Neuroscience.

Chapter 5 Metabolism of the Aging Brain

J. Blass, S. Hoyer, G. Gibson, 1997 .

Differential alterations in antioxidant capacity in cells from Alzheimer patients.

G. Gibson, K. Sheu, K. R. Sheu, 2000, Biochimica et biophysica acta.

Protein‐Bound Acrolein

G. Gibson, K. Uchida, N. Calingasan, 1999, Journal of neurochemistry.

The human brain acetylome reveals that decreased acetylation of mitochondrial proteins associates with Alzheimer's disease

Elizabeth T. Anderson, Shenmin Zhang, G. Gibson, 2021, Journal of neurochemistry.

The α-ketoglutarate dehydrogenase complex in neurodegeneration

J. Blass, G. Gibson, N. Calingasan, 2000, Neurochemistry International.

Abnormalities in the Tricarboxylic Acid Cycle in Huntington Disease and in a Huntington Disease Mouse Model

J. Vonsattel, E. Cortes, G. Gibson, 2015, Journal of neuropathology and experimental neurology.

Ketonic diet in the management of pyruvate dehydrogenase deficiency.

J. Blass, S. Cederbaum, G. Gibson, 1976, Pediatrics.

Carbohydrates and Acetylcholine Synthesis: Implications for Cognitive Disorders

J. Blass, G. Gibson, 1979 .

Cerebrometabolic Aspects of Delirium in Relationship to Dementia

J. Blass, G. Gibson, 1999, Dementia and Geriatric Cognitive Disorders.

Nutritional metabolism and cerebral bioenergetics in Alzheimer's disease and related dementias

H. Feldman, R. Tanzi, J. Luchsinger, 2022, Alzheimer's & dementia : the journal of the Alzheimer's Association.

Selective response of various brain cell types during neurodegeneration induced by mild impairment of oxidative metabolism

G. Gibson, Z. Ke, 2004, Neurochemistry International.

Oxidative processes in the brain and non-neuronal tissues as biomarkers of Alzheimer's disease.

Hsueh‐Meei Huang, G. Gibson, 2002, Frontiers in bioscience : a journal and virtual library.

Inherent Abnormalities in Energy Metabolism in Alzheimer Disease: Interaction with Cerebrovascular Compromise

J. Blass, R. Sheu, G. Gibson, 2000, Annals of the New York Academy of Sciences.

Thiamine-dependent processes and treatment strategies in neurodegeneration.

J. Blass, G. Gibson, 2007, Antioxidants & redox signaling.

Vascular Factors Are Critical in Selective Neuronal Loss in an Animal Model of Impaired Oxidative Metabolism

Paul L Huang, G. Gibson, N. Calingasan, 2000, Journal of neuropathology and experimental neurology.

Abnormalities of mitochondrial enzymes in Alzheimer disease

J. Blass, G. Gibson, K. R. Sheu, 1998, Journal of Neural Transmission.

A mitocentric view of Alzheimer's disease suggests multi-faceted treatments.

G. Gibson, Qingli Shi, 2010, Journal of Alzheimer's disease : JAD.

Oxygen Dependence of Glucose and Acetylcholine Metabolism in Slices and Synaptosomes from Rat Brain

G. Gibson, Hanna J. Ksiezak, 1981, Journal of neurochemistry.

G protein subunit levels in fibroblasts from familial Alzheimer's disease patients: lower levels of the high molecular weight Gsα isoform in patients with decreased β-adrenergic receptor stimulated cAMP formation

L. Lannfelt, J. Johnston, R. Cowburn, 1997, Neuroscience Letters.

The alpha-ketoglutarate-dehydrogenase complex: a mediator between mitochondria and oxidative stress in neurodegeneration.

M. Beal, J. Blass, V. Bunik, 2005, Molecular neurobiology.

Mitochondrial damage in Alzheimer's disease varies with apolipoprotein E genotype

V. Haroutunian, R. Mohs, J. Blass, 2000, Annals of neurology.

4.3 Coupling of Neuronal Function to Oxygen and Glucose Metabolism Through Changes in Neurotransmitter Dynamics as Revealed with Aging, Hypoglycemia, and Hypoxia

J. Joseph, G. Gibson, 2007 .

Disturbances of the Blood-Brain Barrier without Expression of Amyloid Precursor Protein- Containing Neuritic Clusters or Neuronal Loss during Late Stages of Thiamine Deficiency in Guinea Pigs

S. Gandy, G. Gibson, N. Calingasan, 1998, Developmental Neuroscience.

Interrelationships of Energy Metabolism to Oxidative Damage and Neurodegeneration

S. Gandy, G. Gibson, N. Calingasan, 1998 .

Altered calcium uptake in cultured skin fibroblasts from patients with Alzheimer's disease.

J. Blass, G. Gibson, C. Peterson, 1985, The New England journal of medicine.

Differential regulation of adenylyl cyclase in fibroblasts from sporadic and familial Alzheimer's disease cases with PS1 and APP mutations

L. Lannfelt, M. Vestling, R. Cowburn, 1997, Neuroreport.

Altered beta-adrenergic receptor-stimulated cAMP formation in cultured skin fibroblasts from Alzheimer donors.

G. Gibson, H. M. Huang, H. M. Huang, 1993, The Journal of biological chemistry.

Benfotiamine treatment activates the Nrf2/ARE pathway and is neuroprotective in a transgenic mouse model of tauopathy

M. Beal, L. Bettendorff, N. Starkova, 2018, Human molecular genetics.

Improvement of 8-arm maze performance in aged Fischer 344 rats with 3,4-diaminopyridine.

H. Davis, G. Gibson, A. Idowu, 1983, Experimental aging research.

Use of Cultured Fibroblasts in Elucidating the Pathophysiology and Diagnosis of Alzheimer's Disease a

D. Alkon, R. Martins, J. Blass, 1994, Annals of the New York Academy of Sciences.

THE ROLE OF THE CHOLINERGIC SYSTEM IN THIAMIN DEFICIENCY *

J. Blass, G. Gibson, L. Barclay, 1982, Annals of the New York Academy of Sciences.

Regulation | Post Translational Modifications by Succinylation and Acetylation

D. Eliezer, G. Gibson, Diana Acosta, 2020 .

Serum Metabolomic and Lipidomic Profiling Reveals Novel Biomarkers of Efficacy for Benfotiamine in Alzheimer’s Disease

Elizabeth T. Anderson, Shenmin Zhang, G. Gibson, 2021, International journal of molecular sciences.

Abnormalities in oxidative processes in non-neuronal tissues from patients with Alzheimer's disease.

Hui Zhang, G. Gibson, 2001, Journal of Alzheimer's disease : JAD.

Interactions of oxidative stress with thiamine homeostasis promote neurodegeneration

Hui Zhang, G. Gibson, 2002, Neurochemistry International.

Dietary restriction attenuates the neuronal loss, induction of heme oxygenase-1 and blood–brain barrier breakdown induced by impaired oxidative metabolism

G. Gibson, N. Calingasan, 2000, Brain Research.

Phosphonate Analogues of α-Ketoglutarate Inhibit the Activity of the α-Ketoglutarate Dehydrogenase Complex Isolated from Brain and in Cultured Cells†

V. Bunik, C. Thompson, G. Gibson, 2005 .

Correlations of disability and biologic alterations in Alzheimer brain and test of significance by a therapeutic trial in humans.

J. Blass, G. Gibson, 2006, Journal of Alzheimer's disease : JAD.

Consensus report of the working group on: 'Molecular and biochemical markers of Alzheimer's disease'

Giovanni B. Frisoni, Alfredo Robles, Takeshi Iwatsubo, 1998 .

Animal Models of Brain Hypoxia

Hsueh‐Meei Huang, G. Gibson, 1992 .

Impaired mitochondrial energy metabolism as a novel risk factor for selective onset and progression of dementia in oldest-old subjects

V. Haroutunian, P. Katsel, G. Pasinetti, 2015, Neuropsychiatric disease and treatment.

Neuropsychiatric Disease and Treatment Dovepress Impaired Mitochondrial Energy Metabolism as a Novel Risk Factor for Selective Onset and Progression of Dementia in Oldest-old Subjects Pavel L Katsel 2,4

V. Haroutunian, P. Katsel, G. Pasinetti, 2022 .

6.3 Mitochondria-Nucleus Energetic Communication: Role for Phosphotransfer Networks in Processing Cellular Information

A. Lajtha, A. Terzic, G. Dienel, 2007 .

A central cholinergic deficit in rats with dietary thiamin deficiency

J. Blass, G. Gibson, C. J. Pelmas, 1983 .

Reductions in the mitochondrial enzyme α‐ketoglutarate dehydrogenase complex in neurodegenerative disease – beneficial or detrimental?

M. Beal, G. Gibson, N. Calingasan, 2016, Journal of neurochemistry.

α‐ketoglutarate dehydrogenase in alzheimer brains bearing the APP670/671 mutation

G E Gibson, K F Sheu, L. Lannfelt, 1998 .

The role of oxidative abnormalities in the pathophysiology of Alzheimer's disease.

J. Blass, G. Gibson, 1991, Revue neurologique.

Oxidative Stress and a Key Metabolic Enzyme in Alzheimer Brains, Cultured Cells, and an Animal Model of Chronic Oxidative Deficits

S. Sorbi, Hui Zhang, G. Gibson, 1999, Annals of the New York Academy of Sciences.

Dichloroacetate exerts therapeutic effects in transgenic mouse models of Huntington's disease

O. Andreassen, D. Borchelt, C. Ross, 2001, Annals of neurology.

Brain energetics, integration of molecular and cellular processes

Gary E. Gibson, Abel Lajtha, A. Lajtha, 2007 .

Studies of the pathophysiology of pyruvate dehydrogenase deficiency.

J. Blass, G. Gibson, 1978, Advances in neurology.

Acetylcholine Synthesis and CO2 Production from Variously Labeled Glucose in Rat Brain Slices and Synaptosomes

G. Gibson, H. Ksiezak, 1981, Journal of neurochemistry.

Studies on the metabolic pathway of the acetyl group for acetylcholine synthesis.

G. Gibson, M. Shimada, M. Shimada, 1980, Biochemical pharmacology.

Brain acetylcholine synthesis declines with senescence.

D. Jenden, G. Gibson, C. Peterson, 1981, Science.

Synaptosomal Calcium Metabolism During Hypoxia and 3,4‐Diaminopyridine Treatment

G. Gibson, C. Peterson, 1984, Journal of neurochemistry.

Decreases in the release of acetylcholine in vitro with low oxygen.

G. Gibson, C. Peterson, 1982, Biochemical pharmacology.

Oxidative stress in Alzheimer's disease

Hsueh‐Meei Huang, G. Gibson, 2005, Neurobiology of Aging.

Spontaneous open-field behavior in thiamin-deficient rats.

G. Gibson, L. Barclay, 1982, The Journal of nutrition.

Inhibitors of the alpha-ketoglutarate dehydrogenase complex alter [1-13C]glucose and [U-13C]glutamate metabolism in cerebellar granule neurons.

V. Bunik, C. Thompson, G. Gibson, 2006, Journal of neuroscience research.

Behavioral and neurochemical correlates of morphine and hypoxia interactions

G. Gibson, G. Freeman, P. Nielsen, 1986, Pharmacology Biochemistry and Behavior.

Automated method to estimate catecholamine and indoleamine content and turnover rates.

G. Gibson, G. Freeman, P. Nielsen, 1986, Journal of chromatography.

Neurotransmitter and carbohydrate metabolism during senescence.

G. Gibson, C. Peterson, 1982, Experimental brain research.

Aging and 3,4-diaminopyridine alter synaptosomal calcium uptake.

G. Gibson, C. Peterson, 1983, The Journal of biological chemistry.

Pulmonary artery smooth muscle cell [Ca2+]i and contraction: responses to diphenyleneiodonium and hypoxia.

G. Gibson, R. Carson, H. Zhang, 1997, The American journal of physiology.

Amelioration of age-related neurochemical and behavioral deficits by 3,4-diaminopyridine

G. Gibson, C. Peterson, 1983, Neurobiology of Aging.

Thiamine Deficiency as a Model of Selective Neurodegeneration with Chronic Oxidative Deficits

S. Gandy, G. Gibson, N. Calingasan, 1996 .

Cholinergic Dysfunction: A Common Denominator in Metabolic Encephalopathies

F. Plum, J. Blass, G. Gibson, 1981 .

Co-culture with astrocytes or microglia protects metabolically impaired neurons

Hui Zhang, G. Gibson, L. Park, 2001, Mechanisms of Ageing and Development.

Oxidant‐induced Changes in Mitochondria and Calcium Dynamics in the Pathophysiology of Alzheimer's Disease

G. Gibson, S. Karuppagounder, Qingli Shi, 2008, Annals of the New York Academy of Sciences.

Acetylcholine and oxidative metabolism in septum and hippocampus in vitro.

G. Gibson, C. Peterson, 1983, The Journal of biological chemistry.

Novel Metabolic Abnormalities in the Tricarboxylic Acid Cycle in Peripheral Cells From Huntington’s Disease Patients

Zhengming Chen, G. Gibson, L. Park, 2016, PloS one.

The role of the metabolic lesion in Alzheimer's disease.

J. Blass, S. Hoyer, G. Gibson, 2002, Journal of Alzheimer's disease : JAD.

Aging and the brain

G E Gibson, J. Goldman, G. Gibson, 1994, Current opinion in neurology.

Low mutational burden of individual acquired mitochondrial DNA mutations in brain.

Gary E. Gibson, M. F. Beal, M. Beal, 2001, Genomics.

Nonneural markers in Alzheimer disease.

J. Blass, G. Gibson, 1992, Alzheimer disease and associated disorders.

Cytosolic free calcium in lymphoblasts from young, aged and alzheimer subjects

L. Toral-Barza, G. Gibson, L. Toral‐Barza, 1992, Mechanisms of Ageing and Development.

Cellular mitochondrial heterogeneity in cultured astrocytes as demonstrated by immunogold labeling of α‐ketoglutarate dehydrogenase

A. Schousboe, K. Fenger, J. Lindsay, 2006, Glia.

Quantitative α-Ketoglutarate Dehydrogenase Activity Staining in Brain Sections and in Cultured Cells

G. Gibson, N. Calingasan, K. Sheu, 2000 .

Cholinergic therapy of abnormal open-field behavior in thiamin-deficient rats.

J. Blass, G. Gibson, L. Barclay, 1982, The Journal of nutrition.

Interactions of endoplasmic reticulum and mitochondria Ca2+ stores with capacitative calcium entry

Hsueh‐Meei Huang, G. Gibson, Huanlian Chen, 2014, Metabolic Brain Disease.

Peripheral markers in testing pathophysiological hypotheses and diagnosing Alzheimer's disease

D. Alkon, J. Blass, M. Trabucchi, 1998, FASEB journal : official publication of the Federation of American Societies for Experimental Biology.

Inactivation and Reactivation of the Mitochondrial α-Ketoglutarate Dehydrogenase Complex*

G. Gibson, Y. Ye, Hui Xu, 2011, The Journal of Biological Chemistry.

IMPAIRED SYNTHESIS OF ACETYLCHOLINE IN BRAIN ACCOMPANYING MILD HYPOXIA AND HYPOGLYCEMIA

G. E. Gibson, J. Blass, G. Gibson, 1976, Journal of neurochemistry.

Mitochondrial enzymes in schizophrenia

K. Davis, V. Haroutunian, J. Blass, 2007, Journal of Molecular Neuroscience.

High levels of amyloid-β protein from S182 (Glu246) familial Alzheimer's cells

H. Wiśniewski, R. Martins, R. T. Carroll, 1995 .

Nutrition and the Treatment of Neurodegenerative Disease

J. Blass, G. Gibson, 1999 .

A reproducible procedure for primary culture and subsequent maintenance of multiple lines of human skin fibroblasts

J. Blass, V. Cristofalo, G. Gibson, 1998, AGE.

Abnormal Glucose Metabolism in Alzheimer’s Disease: Relation to Autophagy/Mitophagy and Therapeutic Approaches

G. Gibson, Kalpita Banerjee, S. Munshi, 2015, Neurochemical Research.

Cause and consequence: mitochondrial dysfunction initiates and propagates neuronal dysfunction, neuronal death and behavioral abnormalities in age-associated neurodegenerative diseases.

M. Beal, J. Blass, R. Ratan, 2010, Biochimica et biophysica acta.

Oxidant‐induced Changes in Mitochondria and Calcium Dynamics in the Pathophysiology of Alzheimer's Disease

G. Gibson, S. Karuppagounder, Qingli Shi, 2008, Annals of the New York Academy of Sciences.

Inactivation and Reactivation of the Mitochondrial α-Ketoglutarate Dehydrogenase Complex*

G. Gibson, Y. Ye, Hui Xu, 2011, The Journal of Biological Chemistry.

Synaptosomal plasma and mitochondrial membrane potentials during anoxia

G. Gibson, P. Nielsen, L. Toral‐Barza, 1992, Neuroscience Letters.

Peripheral markers of Alzheimer’s disease

G. Gibson, K. R. Sheu, J. P. Blassa, 1997, Aging.