Shiow-Ju Lee

发表

TEB4 is a C4HC3 RING finger-containing ubiquitin ligase of the endoplasmic reticulum.

K. Früh, V. Chau, T. van Laar, 2005, The Biochemical journal.

Guidelines for the use and interpretation of assays formonitoring autophagy (3rd edition)

Sangeeta Khare, Xin Qi, Ying Wang, 2016 .

A Novel Dengue Virus Inhibitor, BP13944, Discovered by High-Throughput Screening with Dengue Virus Replicon Cells Selects for Resistance in the Viral NS2B/NS3 Protease

A. Yueh, Szu-Huei Wu, Shiow-Ju Lee, 2013, Antimicrobial Agents and Chemotherapy.

Novel Dengue Virus-Specific NS2B/NS3 Protease Inhibitor, BP2109, Discovered by a High-Throughput Screening Assay

A. Yueh, Y. Chao, Szu-Huei Wu, 2010, Antimicrobial Agents and Chemotherapy.

A three-dimensional pharmacophore model for dipeptidyl peptidase IV inhibitors.

I. Lu, N. Mahindroo, Xin Chen, 2008, European journal of medicinal chemistry.

Anti-Inflammatory Mechanisms of Phenanthroindolizidine Alkaloids

Shiow-Ju Lee, P. Wu, Cheng-Wei Yang, 2006, Molecular Pharmacology.

Concise synthesis and structure-activity relationships of combretastatin A-4 analogues, 1-aroylindoles and 3-aroylindoles, as novel classes of potent antitubulin agents.

H. Hsieh, Shiow-Ju Lee, J. Liou, 2004, Journal of medicinal chemistry.

Targeting a ribonucleoprotein complex containing the caprin-1 protein and the c-Myc mRNA suppresses tumor growth in mice: an identification of a novel oncotarget

Shiow-Ju Lee, Chih-Hao Lee, Ruey-Bing Yang, 2014, Oncotarget.

Tyrphostin AG1024 Suppresses Coronaviral Replication by Downregulating JAK1 via an IR/IGF-1R Independent Proteolysis Mediated by Ndfip1/2_NEDD4-like E3 Ligase Itch

Shiow-Ju Lee, Cheng-Wei Yang, Yue-Zhi Lee, 2022, Pharmaceuticals.

Natural cardenolides suppress coronaviral replication by downregulating JAK1 via a Na+/K+-ATPase independent proteolysis

Shiow-Ju Lee, Hsin-Yu Chang, Cheng-Wei Yang, 2020, Biochemical Pharmacology.

Novel Small-Molecule Inhibitors of Transmissible Gastroenteritis Virus

Y. Chao, Hwan-You Chang, Shiow-Ju Lee, 2007, Antimicrobial Agents and Chemotherapy.

Tylophorine-based compounds are therapeutic in rheumatoid arthritis by targeting the caprin-1 ribonucleoprotein complex and inhibiting expression of associated c-Myc and HIF-1α.

Linyi Chen, Shiow-Ju Lee, Ruey-Bing Yang, 2019, Pharmacological research.

Remdesivir and Cyclosporine Synergistically Inhibit the Human Coronaviruses OC43 and SARS-CoV-2

C. Chen, Szu-Huei Wu, Shiow-Ju Lee, 2021, Frontiers in Pharmacology.

Cytotoxic cardenolide glycosides from the root of Reevesia formosana.

Shiow-Ju Lee, M. Chiang, Chu-Hung Lin, 2013, Phytochemistry.

Repurposing old drugs as antiviral agents for coronaviruses

C. Chen, Szu-Huei Wu, Shiow-Ju Lee, 2020, Biomedical Journal.

Discovery of selective inhibitors of Glutaminase-2, which inhibit mTORC1, activate autophagy and inhibit proliferation in cancer cells

Y. Chao, Jinq-chyi Lee, Shiow-Ju Lee, 2014, Oncotarget.

Glutamic acid analogues as potent dipeptidyl peptidase IV and 8 inhibitors.

I. Lu, Xin Chen, Su-Ying Wu, 2005, Bioorganic & medicinal chemistry letters.

The cardenolide ouabain suppresses coronaviral replication via augmenting a Na+/K+-ATPase-dependent PI3K_PDK1 axis signaling

Shiow-Ju Lee, Hsin-Yu Chang, Cheng-Wei Yang, 2018, Toxicology and Applied Pharmacology.

Identification of anti-viral activity of the cardenolides, Na+/K+-ATPase inhibitors, against porcine transmissible gastroenteritis virus

Shiow-Ju Lee, I. Chen, Hsun-Shuo Chang, 2017, Toxicology and Applied Pharmacology.

Identification of phenanthroindolizines and phenanthroquinolizidines as novel potent anti-coronaviral agents for porcine enteropathogenic coronavirus transmissible gastroenteritis virus and human severe acute respiratory syndrome coronavirus

Y. Chao, J. Jan, Shiow-Ju Lee, 2010, Antiviral Research.

A new butanolide and a new secobutanolide from Litsea lii var. nunkao-tahangensis

Shiow-Ju Lee, I. Chen, Ming-Jen Cheng †, 2010, Natural product research.

Analogues of 2-phenyl-ethenesulfonic acid phenyl ester have dual functions of inhibiting expression of inducible nitric oxide synthase and activating peroxisome proliferator-activated receptor gamma.

Y. Chao, Shiow-Ju Lee, Iou-Jiun Kang, 2008, Bioorganic & medicinal chemistry letters.

The Synergistic Inhibition of Coronavirus Replication and Induced Cytokine Production by Ciclesonide and the Tylophorine-Based Compound Dbq33b

C. Chen, R. Yang, Shiow-Ju Lee, 2022, Pharmaceutics.

Cytotoxic and anti-HIV principles from the rhizomes of Begonia nantoensis.

Shiow-Ju Lee, K. Lee, P. Wu, 2004, Chemical & pharmaceutical bulletin.

Cytotoxic cardenolides and sesquiterpenoids from the fruits of Reevesia formosana.

Shiow-Ju Lee, I. Chen, Hsun-Shuo Chang, 2016, Phytochemistry.

Cytotoxic Sesquiterpenes from Magnolia kachirachirai

Shiow-Ju Lee, I. Chen, Hsun-Shuo Chang, 2010, Chemistry & biodiversity.

Cytotoxic alkyl benzoquinones and alkyl phenols from Ardisia virens.

Shiow-Ju Lee, I. Chen, Hsun-Shuo Chang, 2009, Phytochemistry.

Inhibition of SARS-CoV-2 by Highly Potent Broad-Spectrum Anti-Coronaviral Tylophorine-Based Derivatives

C. Chen, Szu-Huei Wu, J. Jan, 2020, Frontiers in Pharmacology.

Novel isoindoline compounds for potent and selective inhibition of prolyl dipeptidase DPP8.

Xin Chen, Shiow-Ju Lee, T. Hsu, 2005, Bioorganic & medicinal chemistry letters.

Synthesis and biological evaluation of tylophorine-derived dibenzoquinolines as orally active agents: exploration of the role of tylophorine e ring on biological activity.

Y. Chao, Shiow-Ju Lee, T. Yeh, 2012, Journal of medicinal chemistry.

Synthesis and Cytotoxicity Studies of Cyclohepta[b]indoles, Benzo[6,7]Cyclohepta[1,2‐b]Indoles, Indeno[1,2‐b]Indoles, and Benzo[a]Carbazoles

Shiow-Ju Lee, B. Hong, Yi-Ling Chang, 2006 .

Bioactive composition of Reevesia formosana root and stem with cytotoxic activity potential

Shiow-Ju Lee, Chu-Hung Lin, I. Chen, 2017 .

Antitubercular resorcinol analogs and benzenoid C-glucoside from the roots of Ardisia cornudentata.

Shiow-Ju Lee, I. Chen, Hsun-Shuo Chang, 2010, Planta medica.

Anti-inflammatory effects of 7-methoxycryptopleurine and structure-activity relations of phenanthroindolizidines and phenanthroquinolizidines.

Shiow-Ju Lee, Wen‐Hsin Huang, P. Wu, 2007, Biochemical and biophysical research communications.

Expedient synthesis and structure-activity relationships of phenanthroindolizidine and phenanthroquinolizidine alkaloids.

Shiow-Ju Lee, P. Wu, Cheng-Wei Yang, 2006, Organic & biomolecular chemistry.

Benzothiazolium compounds: novel classes of inhibitors that suppress the nitric oxide production in RAW264.7 cells stimulated by LPS/IFNgamma.

N. Mahindroo, Shiow-Ju Lee, T. Hsu, 2005, Bioorganic & medicinal chemistry letters.

Cytotoxic styrylpyrones from Goniothalamus amuyon.

Y. Wu, F. Chang, Yu-Liang Yang, 1992, Journal of natural products.

Cytotoxic and anti‐HIV Principles from the Rhizomes of Begonia nantoensis.

Shiow-Ju Lee, K. Lee, P. Wu, 2004 .

Secondary Metabolites and Cytotoxic Activities from the Stem Bark of Zanthoxylum nitidum

Shiow-Ju Lee, I. Chen, M. Cheng, 2008, Chemistry & biodiversity.

Artificial intelligence approach fighting COVID-19 with repurposing drugs

Huey-Kang Sytwu, Wen-Hsing Lin, Szu-Huei Wu, 2020, Biomedical Journal.

Secondary Metabolites from the Leaves of Litsea lii var. nunkao-tahangensis

Shiow-Ju Lee, I. Chen, M. Cheng, 2008 .

Cytotoxic styrylpyrones from Goniothalamus amuyon

Y. Wu, F. Chang, Yu-Liang Yang, 2003 .

BPR0L075, a Novel Synthetic Indole Compound with Antimitotic Activity in Human Cancer Cells, Exerts Effective Antitumoral Activity in Vivo

H. Hsieh, C. Chen, Shiow-Ju Lee, 2004, Cancer Research.

Targeting Coronaviral Replication and Cellular JAK2 Mediated Dominant NF-κB Activation for Comprehensive and Ultimate Inhibition of Coronaviral Activity

Y. Chao, C. Shih, Hwan-You Chang, 2017, Scientific Reports.

c-Jun-mediated anticancer mechanisms of tylophorine.

Y. Chao, Hwan-You Chang, Shiow-Ju Lee, 2013, Carcinogenesis.

Calmodulin-dependent Regulation of Inducible and Neuronal Nitric-oxide Synthase*

J. Stull, Shiow-Ju Lee, 1998, The Journal of Biological Chemistry.

Preparation of 2,3-dihetero-substituted 1,3-dienes from brominated 2-sulfolenes

Shiow-Ju Lee, S. Chou, T. Chou, 1988 .

Design, Synthesis, and Evaluation of Thiazolidine-2,4-dione Derivatives as a Novel Class of Glutaminase Inhibitors.

C. Chen, Szu-Huei Wu, Jen‐Shin Song, 2017, Journal of medicinal chemistry.

Isolation and Biological Activities of Phenanthroindolizidine and Septicine Alkaloids from the Formosan Tylophora ovata

Y. Chao, Hwan-You Chang, Shiow-Ju Lee, 2011, Planta medica.

The cardenolides ouabain and reevesioside A promote FGF2 secretion and subsequent FGFR1 phosphorylation via converged ERK1/2 activation.

Shiow-Ju Lee, I. Chen, Chin-Yu Chen, 2019, Biochemical pharmacology.

Erratum to: Guidelines for the use and interpretation of assays for monitoring autophagy (3rd edition) (Autophagy, 12, 1, 1-222, 10.1080/15548627.2015.1100356

Sara W. Bird, Erinna F. Lee, Michael D. Kim, 2016 .

Antitubercular Resorcinols and Cytotoxic Alkyl Benzoquinones from Ardisia kusukuensis

Shiow-Ju Lee, I. Chen, Hsun-Shuo Chang, 2009 .

Discovery of M Protease Inhibitors Encoded by SARS-CoV-2

C. Chen, J. Hsu, Szu-Huei Wu, 2020, Antimicrobial Agents and Chemotherapy.

Cytotoxic flavonoids from the leaves of Cryptocarya chinensis.

Shiow-Ju Lee, M. Chiang, I. Chen, 2010, Journal of Natural Products.

Tylophorine arrests carcinoma cells at G1 phase by downregulating cyclin A2 expression.

Y. Chao, Shiow-Ju Lee, P. Wu, 2009, Biochemical and biophysical research communications.

Mutations at Lysine 525 of Inducible Nitric-oxide Synthase Affect Its Ca2+-independent Activity*

J. Stull, Shiow-Ju Lee, K. Beckingham, 2000, The Journal of Biological Chemistry.

Natural fucoidans inhibit coronaviruses by targeting viral spike protein and host cell furin.

J. Jan, Shiow-Ju Lee, Sui‐Yuan Chang, 2023, Biochemical pharmacology.

2-[3-[2-[(2S)-2-Cyano-1-pyrrolidinyl]-2-oxoethylamino]-3-methyl-1-oxobutyl]- 1,2,3,4-tetrahydroisoquinoline: a potent, selective, and orally bioavailable dipeptide-derived inhibitor of dipeptidyl peptidase IV.

I. Lu, H. Hsieh, C. Chen, 2006, Journal of medicinal chemistry.