E. Wiertz

发表

TEB4 is a C4HC3 RING finger-containing ubiquitin ligase of the endoplasmic reticulum.

K. Früh, V. Chau, T. van Laar, 2005, The Biochemical journal.

Synthesis and biological evaluation of a chitobiose-based peptide N-glycanase inhibitor library.

H. Overkleeft, G. A. van der Marel, E. Wiertz, 2009, The Journal of organic chemistry.

RNA accessibility impacts potency of Tough Decoy microRNA inhibitors

E. Kruse, E. Wiertz, J. A. Soppe, 2018, RNA biology.

The Comparative Genomics of Human Respiratory Syncytial Virus Subgroups A and B: Genetic Variability and Molecular Evolutionary Dynamics

P. Lemey, E. Wiertz, M. Viveen, 2013, Journal of Virology.

Genetic Variability among Complete Human Respiratory Syncytial Virus Subgroup A Genomes: Bridging Molecular Evolutionary Dynamics and Epidemiology

P. Lemey, N. Jansen, E. Wiertz, 2012, PloS one.

Herpesvirus Interference with Major Histocompatibility Complex Class II-Restricted T-Cell Activation

M. Ressing, E. Wiertz, H. Collins, 2006, Journal of Virology.

Rat cytomegalovirus induces a temporal downregulation of major histocompatibility complex class I cell surface expression.

D. Koppers-Lalic, G. Hassink, E. Wiertz, 2005, Viral immunology.

Targeting of EBNA1 for Rapid Intracellular Degradation Overrides the Inhibitory Effects of the Gly-Ala Repeat Domain and Restores CD8+ T Cell Recognition*

S. Burrows, R. Khanna, D. Moss, 2001, The Journal of Biological Chemistry.

Immune evasion by human cytomegalovirus: lessons in immunology and cell biology.

E. Wiertz, W. Loenen, C. Bruggeman, 2001, Seminars in immunology.

EBV Lytic-Phase Protein BGLF5 Contributes to TLR9 Downregulation during Productive Infection

M. Ressing, M. Buisson, E. Wiertz, 2011, The Journal of Immunology.

CRISPR/Cas9-Mediated Genome Editing of Herpesviruses Limits Productive and Latent Infections

Anita C. Schürch, Monique Nijhuis, E. Kruse, 2016, PLoS pathogens.

Human Population TAP-Inhibited Cells Are Readily Detected in T Cell Responses against + CD 8 Thorbald van Hall

E. Wiertz, S. H. Burg, Bianca J. Querido, 2010 .

Epstein-Barr Virus Large Tegument Protein BPLF1 Contributes to Innate Immune Evasion through Interference with Toll-Like Receptor Signaling

Steven G. E. Braem, E. Kremmer, M. Ressing, 2014, PLoS pathogens.

Epstein-Barr Virus Large Tegument Protein BPLF 1 Contributes to Innate Immune Evasion through Interference with Toll-Like Receptor Signaling

Steven G. E. Braem, E. Kremmer, M. Ressing, 2014 .

The “Bridge” in the Epstein-Barr Virus Alkaline Exonuclease Protein BGLF5 Contributes to Shutoff Activity during Productive Infection

M. Ressing, A. Gorbalenya, M. Buisson, 2012, Journal of Virology.

Distinct kinetics and dynamics of cross‐presentation in liver sinusoidal endothelial cells compared to dendritic cells

Sven Burgdorf, Patrick Penzler, Silke Hegenbarth, 2009, Hepatology.

Splenic Red Pulp Macrophages Cross-Prime Early Effector CTL That Provide Rapid Defense against Viral Infections

E. Wiertz, C. Kurts, N. Garbi, 2019, The Journal of Immunology.

A CD8+ T cell immune evasion protein specific to Epstein-Barr virus and its close relatives in Old World primates

M. Ressing, J. Neefjes, N. Croft, 2007, The Journal of experimental medicine.

Exploitation of Herpesvirus Immune Evasion Strategies to Modify the Immunogenicity of Human Mesenchymal Stem Cell Transplants

E. Wiertz, A. D. de Vries, Hester Boersma, 2011, PloS one.

Ubiquitination of MHC Class I Heavy Chains Is Essential for Dislocation by Human Cytomegalovirus-encoded US2 but Not US11*

G. Hassink, M. Kikkert, Sjaak van Voorden, 2006, Journal of Biological Chemistry.

Human HRD1 Is an E3 Ubiquitin Ligase Involved in Degradation of Proteins from the Endoplasmic Reticulum*

V. Chau, G. Hassink, M. Kikkert, 2004, Journal of Biological Chemistry.

A Broad-Spectrum Antiviral Peptide Blocks Infection of Viruses by Binding to Phosphatidylserine in the Viral Envelope

J. Killian, J. Drijfhout, A. I. Costa, 2020, Cells.

The E3 Ubiquitin Ligases Hrd1 and gp78 Bind to and Promote Cholera Toxin Retro-Translocation

Y. Ye, M. Kikkert, Sjaak van Voorden, 2010, Molecular biology of the cell.

The nested open reading frame in the Epstein-Barr virus nuclear antigen-1 mRNA encodes a protein capable of inhibiting antigen presentation in cis.

M. Ressing, E. Wiertz, R. Hoeben, 2007, Molecular immunology.

Ube2j2 ubiquitinates hydroxylated amino acids on ER-associated degradation substrates

E. Wiertz, M. Rabelink, R. Hoeben, 2009, The Journal of cell biology.

The E3 Ubiquitin Ligase TMEM129 Is a Tri-Spanning Transmembrane Protein

A. I. Costa, E. Wiertz, R. Lebbink, 2016, Viruses.

Recruitment of the p 97 ATPase and ubiquitin ligases to the site of retrotranslocation at the endoplasmic reticulum membrane

T. Rapoport, Y. Ye, M. Kikkert, 2005 .

The Epstein-Barr Virus Glycoprotein gp150 Forms an Immune-Evasive Glycan Shield at the Surface of Infected Cells

H. Vrolijk, D. Tscharke, M. Ressing, 2016, PLoS pathogens.

T-cell responses to outer membrane proteins of Neisseria meningitidis: comparative study of the Opa, Opc, and PorA proteins

M. Achtman, E. Wiertz, J. Poolman, 1996, Infection and immunity.

Identification of T cell epitopes occurring in a meningococcal class 1 outer membrane protein using overlapping peptides assembled with simultaneous multiple peptide synthesis

E. Wiertz, J. Poolman, P. Hoogerhout, 1992, The Journal of experimental medicine.

Inhibition of mouse TAP by immune evasion molecules encoded by non-murine herpesviruses.

J. Drijfhout, M. Ressing, E. Wiertz, 2011, Molecular immunology.

Cowpox Virus Protein CPXV012 Eludes CTLs by Blocking ATP Binding to TAP

E. Kremmer, J. Drijfhout, M. Ressing, 2014, The Journal of Immunology.

Exploiting human herpesvirus immune evasion for therapeutic gain: potential and pitfalls

M. Ressing, E. Wiertz, D. Horst, 2011, Immunology and cell biology.

Specific Targeting of the EBV Lytic Phase Protein BNLF2a to the Transporter Associated with Antigen Processing Results in Impairment of HLA Class I-Restricted Antigen Presentation1

E. Kremmer, M. Ressing, N. Croft, 2009, The Journal of Immunology.

Impairment of HLA Class I-Restricted Associated with Antigen Processing Results in Protein BNLF2a to the Transporter Specific Targeting of the EBV Lytic Phase

M. Ressing, N. Croft, A. Rickinson, 2009 .

Human cytomegalovirus-encoded US2 and US11 target unassembled MHC class I heavy chains for degradation.

G. Hassink, Sjaak van Voorden, E. Wiertz, 2006, Molecular immunology.

Manipulation of the immune response by Epstein-Barr virus and Kaposi's sarcoma-associated herpesvirus: consequences for tumor development.

M. Ressing, E. Wiertz, 2008, Seminars in cancer biology.

The TRC8 E3 ligase ubiquitinates MHC class I molecules before dislocation from the ER

Mair E. M. Thomas, P. Lehner, R. Gemmill, 2009, The Journal of cell biology.

Two mechanistically distinct immune evasion proteins of cowpox virus combine to avoid antiviral CD8 T cells.

E. Wiertz, D. Pickup, W. Yokoyama, 2009, Cell host & microbe.

EBV Protein BNLF2a Exploits Host Tail-Anchored Protein Integration Machinery To Inhibit TAP

E. Kremmer, M. Ressing, H. V. van Leeuwen, 2011, The Journal of Immunology.

Stage-Specific Inhibition of MHC Class I Presentation by the Epstein-Barr Virus BNLF2a Protein during Virus Lytic Cycle

E. Kremmer, M. Ressing, N. Croft, 2009, PLoS pathogens.

Genetically engineered human islets protected from CD8-mediated autoimmune destruction in vivo.

M. Engelse, F. Carlotti, E. D. de Koning, 2013, Molecular therapy : the journal of the American Society of Gene Therapy.

The tetraspanin protein CD82 associates with both free HLA class I heavy chain and heterodimeric beta 2-microglobulin complexes.

H. Ploegh, D. Fradelizi, E. Wiertz, 1997, Journal of immunology.

Endogenous HLA class II epitopes that are immunogenic in vivo show distinct behavior toward HLA-DM and its natural inhibitor HLA-DO.

J. Goeman, J. Falkenburg, M. Griffioen, 2012, Blood.

Human Cytomegalovirus-Encoded US2 Differentially Affects Surface Expression of MHC Class I Locus Products and Targets Membrane-Bound, but Not Soluble HLA-G1 for Degradation 1

M. Ressing, E. Wiertz, P. Le Bouteiller, 2003, The Journal of Immunology.

Membrane-Bound, but Not Soluble HLA-G1 MHC Class I Locus Products and Targets Differentially Affects Surface Expression of Human Cytomegalovirus-Encoded US2

M. Ressing, E. Wiertz, P. Bouteiller, 2003 .

Degradation Membrane-Bound , but Not Soluble HLA-G 1 MHC Class I Locus Products and Targets Differentially Affects Surface Expression of Human Cytomegalovirus-Encoded US 2

M. Ressing, E. Wiertz, P. Bouteiller, 2003 .

The HCMV Gene Products US11 and US2 Differ in Their Ability to Attack Allelic Forms of Murine Major Histocompatibility Complex (MHC) Class I Heavy Chains

H. Ploegh, E. Wiertz, R. Machold, 1997, The Journal of experimental medicine.

Amino acid composition of (cid:68) 1 / (cid:68) 2 domains and cy toplasmic tail of M H C class I mole cu to 1 -me

E. Wiertz, P. Bouteiller, D. V. Leeuwen, 2006 .

Amino acid composition of α1/α2 domains and cytoplasmic tail of MHC class I molecules determine their susceptibility to human cytomegalovirus US11‐mediated down‐regulation

E. Wiertz, P. Bouteiller, D. van Leeuwen, 2003, European journal of immunology.

Viral evasion of T cell immunity: ancient mechanisms offering new applications.

M. Ressing, A. Davison, E. Wiertz, 2011, Current opinion in immunology.

Interference with T cell receptor–HLA-DR interactions by Epstein–Barr virus gp42 results in reduced T helper cell recognition

T. Schumacher, M. Schilham, M. Ressing, 2003, Proceedings of the National Academy of Sciences of the United States of America.

Suppression of a Natural Killer Cell Response by Simian Immunodeficiency Virus Peptides

E. Wiertz, N. Wilson, D. Evans, 2015, PLoS pathogens.

Host shutoff during productive Epstein–Barr virus infection is mediated by BGLF5 and may contribute to immune evasion

M. Ressing, M. Rowe, D. Ganem, 2007, Proceedings of the National Academy of Sciences.

The Capacity of UL49.5 Proteins To Inhibit TAP Is Widely Distributed among Members of the Genus Varicellovirus

M. Ressing, K. Bieńkowska-Szewczyk, J. Cohen, 2010, Journal of Virology.

Viral interference with antigen presentation: trapping TAP.

M. Ressing, E. Wiertz, D. Horst, 2012, Molecular immunology.

EBV BILF1 Evolved To Downregulate Cell Surface Display of a Wide Range of HLA Class I Molecules through Their Cytoplasmic Tail

M. Ressing, F. Claas, E. Wiertz, 2013, The Journal of Immunology.

Biosafety assessment of probiotics used for human consumption: recommendations from the EU-PROSAFE project

H. Goossens, V. Vankerckhoven, E. Vaughan, 2008 .

Adenoviral Vectors Stimulate Glucagon Transcription in Human Mesenchymal Stem Cells Expressing Pancreatic Transcription Factors

F. Carlotti, E. Wiertz, M. Gonçalves, 2012, PloS one.

Interaction of pertussis toxin with human T lymphocytes

E. Wiertz, J. Poolman, M. Vogel, 1992, Infection and immunity.

Alternative Ii-independent antigen-processing pathway in leukemic blasts involves TAP-dependent peptide loading of HLA class II complexes

M. Ressing, G. Ossenkoppele, E. Wiertz, 2010, Cancer Immunology, Immunotherapy.

Sec6l-mediated transfer of a membrane protein from the endoplasmic reticulum to the proteasome for destruction

T. Rapoport, M. Bogyo, H. Ploegh, 1996, Nature.

A Flow Cytometry-Based Approach to Unravel Viral Interference with the MHC Class I Antigen Processing and Presentation Pathway.

E. Wiertz, Hendrik de Buhr, P. Praest, 2019, Methods in molecular biology.

Evaluation of viral interference with MHC class I-restricted antigen processing and presentation using a flow cytometry-based approach.

M. Ressing, E. Wiertz, D. Horst, 2013, Methods in molecular biology.

The Epstein-Barr Virus G-Protein-Coupled Receptor Contributes to Immune Evasion by Targeting MHC Class I Molecules for Degradation

M. Ressing, A. Currin, M. Rowe, 2009, PLoS pathogens.

The UL 41-encoded virion host shutoff ( vhs ) protein and vhs-independent mechanisms are responsible for down-regulation of MHC class I molecules by bovine herpesvirus 1

M. Ressing, E. Wiertz, E. Reits, 2007 .

DISLOCATED FROM THE ENDOPLASMIC RETICULUM TO THE CYTOSOL IN A VECTORIAL FASHION, COMMENCING AT THE C-TERMINUS

G. Hassink, E. Wiertz, F. J. Wal, 2006 .

Bovine herpesvirus 1 interferes with TAP-dependent peptide transport and intracellular trafficking of MHC class I molecules in human cells

M. Ressing, J. Neefjes, K. Bieńkowska-Szewczyk, 2003, Archives of Virology.

In vitro processing and presentation of a lipidated cytotoxic T-cell epitope derived from measles virus fusion protein.

A. Osterhaus, P. Roholl, E. Wiertz, 2001, Vaccine.

The UL41-encoded virion host shutoff (vhs) protein and vhs-independent mechanisms are responsible for down-regulation of MHC class I molecules by bovine herpesvirus 1.

M. Ressing, J. Neefjes, D. Koppers-Lalic, 2001, The Journal of general virology.

Cytomegaloviruses use multiple mechanisms to elude the host immune response.

H. Ploegh, D. Tortorella, E. Wiertz, 1997, Immunology letters.

Viruses use stealth technology to escape from the host immune system.

H. Ploegh, E. Wiertz, S. Mukherjee, 1997, Molecular medicine today.

In vitro induction of antigen specific antibody synthesis and proliferation of T lymphocytes with acellular pertussis vaccines, pertussis toxin and filamentous haemagglutinin in humans.

E. Wiertz, H. C. Walvoort, J. G. Kreeftenberg, 1989, Journal of biological standardization.

Acellular and whole cell pertussis vaccines protect against the lethal effects of intracerebral challenge by two different T-cell dependent humoral routes.

H. van Loveren, E. Wiertz, H. C. Walvoort, 1990, Biologicals : journal of the International Association of Biological Standardization.

T cell recognition of Neisseria meningitidis class 1 outer membrane proteins. Identification of T cell epitopes with selected synthetic peptides and determination of HLA restriction elements.

E. Wiertz, J. Poolman, P. Hoogerhout, 1991, Journal of immunology.

Reduced human leukocyte antigen expression in advanced‐stage Ewing sarcoma: implications for immune recognition

U. Dirksen, M. Schilham, K. Schaefer, 2009, The Journal of pathology.

Non-specific modulation of the immune response with liposomal meningococcal lipopolysaccharide: role of different cells and cytokines.

E. Wiertz, J. Poolman, V. Kolenko, 1994, Vaccine.

Mapping of human T-cell epitopes, occurring in the meningococcal class 1 outer membrane protein

E. Wiertz, J. Poolman, P. Hoogerhout, 1990 .

Human cytomegalovirus US3 impairs transport and maturation of major histocompatibility complex class I heavy chains.

H. Ploegh, K. Fish, L. Sun, 1996, Proceedings of the National Academy of Sciences of the United States of America.

The modified leukocytosis promoting factor (LPF)-test: a valuable supplement to the mouse weight gain (MWG)-test in toxicity control of whole cell pertussis vaccine.

E. Wiertz, D. Borsboom, F. Marsman, 1992, Biologicals : journal of the International Association of Biological Standardization.

Molecular Immunology The in ﬂ uence of TAP1 and TAP2 gene polymorphisms on TAP function and its inhibition by viral immune evasion proteins

E. Wiertz, R. Lebbink, J. Lanfermeijer, 2018 .

The SARS-CoV-2 accessory factor ORF7a downregulates MHC class I surface expression

E. Wiertz, L. Kapitein, W. Nijenhuis, 2022, bioRxiv.

Adenovirus targeting to HLA-A1/MAGE-A1-positive tumor cells by fusing a single-chain T-cell receptor with minor capsid protein IX

E. Wiertz, M. Verweij, J. Vellinga, 2008, Gene Therapy.

Cowpox virus inhibits the transporter associated with antigen processing to evade T cell recognition.

K. Früh, C. Upton, E. Wiertz, 2009, Cell host & microbe.

Antibodies to Bordetella pertussis adenylate cyclase are produced in man during pertussis infection and after vaccination.

E. Wiertz, Z. Farfel, E. Hanski, 1990, Journal of medical microbiology.

Second generation meningococcal OMP-LPS vaccines.

E. Wiertz, P. A. van der Ley, J. Poolman, 1991, NIPH annals.

The DNase of Gammaherpesviruses Impairs Recognition by Virus-Specific CD8+ T Cells through an Additional Host Shutoff Function

M. Ressing, M. Rowe, Jaap M Middeldorp, 2007, Journal of Virology.

TAP Mediates Import of Mycobacterium tuberculosis-Derived Peptides into Phagosomes and Facilitates Loading onto HLA-I

E. Wiertz, Sven Burgdorf, C. Kurts, 2013, PloS one.

Noncytotoxic Inhibition of Cytomegalovirus Replication through NK Cell Protease Granzyme M-Mediated Cleavage of Viral Phosphoprotein 71

N. Bovenschen, R. Quadir, E. Wiertz, 2010, The Journal of Immunology.

Phosphoprotein 71 Granzyme M-Mediated Cleavage of Viral Replication through NK Cell Protease Noncytotoxic Inhibition of Cytomegalovirus Bovenschen

Niels, R. Quadir, E. Wiertz, 2010 .

Immune Evasion by Epstein-Barr Virus.

M. Ressing, E. Wiertz, Michiel van Gent, 2015, Current topics in microbiology and immunology.

Meningococcal lipopolysaccharide (LPS)-derived oligosaccharide-protein conjugates evoke outer membrane protein- but not LPS-specific bactericidal antibodies in mice: influence of adjuvants

J. Verhoef, E. Wiertz, J. Poolman, 1993, Infection and immunity.

Exploiting the exploiter: a viral inhibitor stabilizes TAP for cryo-EM

E. Wiertz, R. Luteijn, 2016, Nature Structural &Molecular Biology.

In cis inhibition of antigen processing by the latency-associated nuclear antigen I of Kaposi sarcoma herpes virus.

E. Wiertz, R. Hoeben, A. Zaldumbide, 2007, Molecular immunology.

Bovine Herpesvirus 1 UL49.5 Protein Inhibits the Transporter Associated with Antigen Processing despite Complex Formation with Glycoprotein M

K. Bieńkowska-Szewczyk, D. Koppers-Lalic, E. Wiertz, 2006, Journal of Virology.

Impaired Transporter Associated with Antigen Processing-Dependent Peptide Transport during Productive EBV Infection1

M. Ressing, M. Rowe, D. Koppers-Lalic, 2005, The Journal of Immunology.

The DNase of Gammaherpesviruses Impairs Recognition by Virus-Speciﬁc CD8 (cid:1) T Cells through an Additional Host Shutoff Function (cid:1)

M. Ressing, M. Rowe, E. Wiertz, 2008 .

Silencing the shutoff protein of Epstein-Barr virus in productively infected B cells points to (innate) targets for immune evasion.

M. Ressing, E. Wiertz, Michiel van Gent, 2015, The Journal of general virology.

Herpesviruses and immunity: the art of evasion.

E. Wiertz, B. Griffin, M. Verweij, 2010, Veterinary microbiology.

Structural and functional analysis of the TAP-inhibiting UL49.5 proteins of varicelloviruses.

J. Koch, M. Ressing, H. V. van Leeuwen, 2011, Molecular immunology.

Varicellovirus UL49.5 Proteins Differentially Affect the Function of the Transporter Associated with Antigen Processing, TAP

R. Tampé, J. Koch, M. Ressing, 2008, PLoS pathogens.

Varicelloviruses avoid T cell recognition by UL49.5-mediated inactivation of the transporter associated with antigen processing.

R. Tampé, J. Koch, M. Ressing, 2005, Proceedings of the National Academy of Sciences of the United States of America.

The ER-luminal domain of the HCMV glycoprotein US6 inhibits peptide translocation by TAP.

P. A. Peterson, A. Gruhler, H. Ploegh, 1997, Immunity.

Enhanced antigen cross-presentation in human colorectal cancer-associated fibroblasts through upregulation of the lysosomal protease cathepsin S

S. H. van der Burg, Gerbrand J. van der Heden van Noort, E. Wiertz, 2022, Journal for ImmunoTherapy of Cancer.

Mutagenic repair of double-stranded DNA breaks in vaccinia virus genomes requires cellular DNA ligase IV activity in the cytosol.

Geoffrey L. Smith, E. Wiertz, R. Lebbink, 2018, The Journal of general virology.

Dislocation of Type I Membrane Proteins from the ER to the Cytosol Is Sensitive to Changes in Redox Potential

H. Ploegh, D. Tortorella, E. Wiertz, 1998, The Journal of cell biology.

The Human Cytomegalovirus US11 Gene Product Dislocates MHC Class I Heavy Chains from the Endoplasmic Reticulum to the Cytosol

M. Bogyo, H. Geuze, H. Ploegh, 1996, Cell.

The UFM1 Pathway Impacts HCMV US2-Mediated Degradation of HLA Class I

A. Pichlmair, E. Wiertz, E. Bouma, 2021, Molecules.

Recruitment of the p97 ATPase and ubiquitin ligases to the site of retrotranslocation at the endoplasmic reticulum membrane.

T. Rapoport, Y. Ye, M. Kikkert, 2005, Proceedings of the National Academy of Sciences of the United States of America.

The HCMV gene products US2 and US11 target MHC class I molecules for degradation in the cytosol.

M. Kikkert, E. Wiertz, F. J. van der Wal, 2002, Current topics in microbiology and immunology.

Viral Inhibition of the Transporter Associated with Antigen Processing (TAP): A Striking Example of Functional Convergent Evolution

M. Ressing, A. Davison, E. Wiertz, 2015, PLoS pathogens.

Comprehensive profiling of functional Epstein-Barr virus miRNA expression in human cell lines

E. Kruse, E. Wiertz, R. Lebbink, 2016, BMC Genomics.

EBV MicroRNA BART16 Suppresses Type I IFN Signaling

F. Holstege, M. Ressing, D. van Leenen, 2017, The Journal of Immunology.

Signaling of a Varicelloviral Factor across the Endoplasmic Reticulum Membrane Induces Destruction of the Peptide-loading Complex and Immune Evasion*

R. Tampé, J. Koch, E. Wiertz, 2008, Journal of Biological Chemistry.

Viral immune evasion: Lessons in MHC class I antigen presentation.

E. Wiertz, R. Luteijn, M. Van de Weijer, 2015, Seminars in immunology.

Viral immune evasion: a masterpiece of evolution

E. Wiertz, C. Söderberg-Nauclér, Mireille T. Vossen, 2002, Immunogenetics.

New insights into the structure of the MHC class I peptide-loading complex and mechanisms of TAP inhibition by viral immune evasion proteins.

F. Förster, E. Wiertz, A. Liaci, 2019, Molecular immunology.

A combinational CRISPR/Cas9 gene-editing approach can halt HIV replication and prevent viral escape

E. Kruse, E. Wiertz, R. Lebbink, 2017, Scientific Reports.

A bridge crosses the active-site canyon of the Epstein-Barr virus nuclease with DNase and RNase activities.

M. Ressing, M. Buisson, E. Wiertz, 2009, Journal of molecular biology.

Pathogenicity of Bovine Neonatal Pancytopenia-associated vaccine-induced alloantibodies correlates with Major Histocompatibility Complex class I expression

E. Wiertz, V. Rutten, P. V. van Kooten, 2015, Scientific Reports.

A Genome-Wide Haploid Genetic Screen Identifies Heparan Sulfate-Associated Genes and the Macropinocytosis Modulator TMED10 as Factors Supporting Vaccinia Virus Infection

T. Brummelkamp, E. Wiertz, T. V. van Kuppevelt, 2019, Journal of Virology.

A class II MHC-targeted vaccine elicits immunity against SARS-CoV-2 and its variants

S. Whelan, H. Ploegh, Louis-Marie Bloyet, 2021, Proceedings of the National Academy of Sciences.

Fluorescent TAP as a Platform for Virus-Induced Degradation of the Antigenic Peptide Transporter

K. Bieńkowska-Szewczyk, E. Wiertz, A. Lipińska, 2019, Cells.

The transporter associated with antigen processing (TAP) is active in a post-ER compartment

R. Tampé, P. van Endert, E. Ghanem, 2010, Journal of Cell Science.

The Varicellovirus UL49.5 Protein Blocks the Transporter Associated with Antigen Processing (TAP) by Inhibiting Essential Conformational Transitions in the 6+6 Transmembrane TAP Core Complex1

R. Tampé, J. Koch, M. Ressing, 2008, The Journal of Immunology.

The Varicellovirus UL 49 . 5 Protein Blocks the Transporter Associated with Antigen Processing ( TAP ) by Inhibiting Essential Conformational Transitions in the 6 6 Transmembrane TAP Core Complex 1

R. Tampé, J. Koch, M. Ressing, 2008 .

Epstein-Barr Virus gp42 Is Posttranslationally Modified To Produce Soluble gp42 That Mediates HLA Class II Immune Evasion

T. Schumacher, M. Ressing, T. Ottenhoff, 2005, Journal of Virology.

A genome-wide haploid genetic screen for essential factors in vaccinia virus infection identifies TMED10 as regulator of macropinocytosis

T. Brummelkamp, E. Wiertz, T. V. van Kuppevelt, 2018, bioRxiv.

A genome-wide haploid genetic screen for essential factors in vaccinia virus 1 infection identifies TMED 10 as regulator of macropinocytosis 2 3 Running title : Macropinocytosis of Vaccinia virus is regulated by TMED 10 4 5

T. Brummelkamp, E. Wiertz, T. V. van Kuppevelt, 2018 .

Subtle sequence variation among MHC class I locus products greatly influences sensitivity to HCMV US2- and US11-mediated degradation.

E. Wiertz, P. Le Bouteiller, Philippe Le Bouteiller, 2006, International immunology.

Ubiquitination of serine, threonine, or lysine residues on the cytoplasmic tail can induce ERAD of MHC-I by viral E3 ligase mK3

E. Wiertz, L. Lybarger, Xiaoli Wang, 2007, The Journal of cell biology.

Endocytosed soluble cowpox virus protein CPXV012 inhibits antigen cross‐presentation in human monocyte‐derived dendritic cells

M. Boes, E. Wiertz, S. Nierkens, 2018, Immunology and cell biology.

Proteasomal Degradation of Proinsulin Requires Derlin-2, HRD1 and p97

M. Engelse, E. D. de Koning, E. Wiertz, 2015, PloS one.

TAP-inhibiting proteins US6, ICP47 and UL49.5 differentially affect minor and major histocompatibility antigen-specific recognition by cytotoxic T lymphocytes.

M. Ressing, D. Koppers-Lalic, E. Wiertz, 2007, International immunology.

The role of the ubiquitination machinery in dislocation and degradation of endoplasmic reticulum proteins.

G. Hassink, M. Kikkert, E. Wiertz, 2005, Current topics in microbiology and immunology.

Epstein-Barr Virus Isolates Retain Their Capacity To Evade T Cell Immunity through BNLF2a despite Extensive Sequence Variation

M. Ressing, S. Burrows, M. J. Bell, 2011, Journal of Virology.

The Varicellovirus-Encoded TAP Inhibitor UL49.5 Regulates the Presentation of CTL Epitopes by Qa-1b1

J. Koch, R. Offringa, D. Koppers-Lalic, 2007, The Journal of Immunology.

CD8+ T Cell Responses against TAP-Inhibited Cells Are Readily Detected in the Human Population

S. H. van der Burg, E. Wiertz, T. van Hall, 2010, The Journal of Immunology.

Induction of protective CTL immunity against peptide transporter TAP-deficient tumors through dendritic cell vaccination.

R. Offringa, H. Ljunggren, E. Wiertz, 2007, Cancer research.

Epitopes by Qa-1 UL 49 . 5 Regulates the Presentation of CTL The Varicellovirus-Encoded TAP Inhibitor Offringa and

J. Koch, R. Offringa, D. Koppers-Lalic, 2006 .

Microheterogeneity in the recognition of a HLA‐DR2‐restricted T cell epitope from a meningococcal outer membrane protein

E. Wiertz, J. Poolman, P. Hoogerhout, 1993, European journal of immunology.

Ubiquitination is essential for human cytomegalovirus US11-mediated dislocation of MHC class I molecules from the endoplasmic reticulum to the cytosol.

G. Hassink, M. Kikkert, E. Wiertz, 2001, The Biochemical journal.

Epstein-Barr virus evasion of CD8(+) and CD4(+) T cell immunity via concerted actions of multiple gene products.

M. Ressing, Rekha Khanna, M. Rowe, 2008, Seminars in cancer biology.

Transmembrane regions of bovine herpesvirus 1-encoded UL49.5 and glycoprotein M regulate complex maturation and ER-Golgi trafficking.

K. Bieńkowska-Szewczyk, E. Wiertz, M. Ackermann, 2019, The Journal of general virology.

The ubiquitin-domain protein HERP forms a complex with components of the endoplasmic reticulum associated degradation pathway.

P. Kloetzel, F. Koning, M. Seeger, 2005, Journal of molecular biology.

Quality Control of ER Membrane Proteins by the RNF185/Membralin Ubiquitin Ligase Complex

Pedro Carvalho, R. Fischer, S. Liberatori, 2020, Molecular cell.

A high-coverage shRNA screen identifies TMEM129 as an E3 ligase involved in ER-associated protein degradation

Michael T. McManus, J. Weissman, E. Leproust, 2014, Nature Communications.

Multiple-stage tandem mass spectrometry for structural characterization of saponins.

E. Wiertz, J. Kamerling, G. van de Werken, 1998, Analytical chemistry.

EBV Protein BNLF2a Exploits Host Tail-Anchored Protein Integration Machinery To Inhibit TAP

E. Kremmer, M. Ressing, H. V. van Leeuwen, 2011, The Journal of Immunology.

CYP3A4 ubiquitination by gp78 (the tumor autocrine motility factor receptor, AMFR) and CHIP E3 ligases.

C. Patterson, E. Wiertz, M. Correia, 2009, Archives of biochemistry and biophysics.

MHC class I molecules are preferentially ubiquitinated on endoplasmic reticulum luminal residues during HRD1 ubiquitin E3 ligase-mediated dislocation

P. Lehner, E. Wiertz, R. Antrobus, 2013, Proceedings of the National Academy of Sciences.

Recent advances in viral evasion of the MHC Class I processing pathway.

E. Wiertz, Ana I. Costa, A. Schuren, 2016, Current opinion in immunology.

Multiple E2 ubiquitin-conjugating enzymes regulate human cytomegalovirus US2-mediated immunoreceptor downregulation

P. Lehner, F. Claas, E. Wiertz, 2017, Journal of Cell Science.

The influence of TAP1 and TAP2 gene polymorphisms on TAP function and its inhibition by viral immune evasion proteins

E. Wiertz, R. Lebbink, J. Lanfermeijer, 2018, Molecular immunology.

Proinsulin degradation and presentation of a proinsulin B-chain autoantigen involves ER-associated protein degradation (ERAD)-enzyme UBE2G2

E. Wiertz, P. V. van Veelen, R. Lebbink, 2023, bioRxiv.

Ion trap multiple-stage tandem mass spectrometry as a pre-NMR tool in the structure elucidation of saponins

E. Wiertz, J. Kamerling, B. R. Leeflang, 2000 .

Quality Control of ER Membrane Proteins by the RNF185/Membralin Ubiquitin Ligase Complex

Pedro Carvalho, R. Fischer, S. Liberatori, 2020, Molecules and Cells.

Interaction ofPertussis ToxinwithHumanT Lymphocytes

E. Wiertz, M. Witvliet, 1992 .