M. Jaffar

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Menadione-induced Reactive Oxygen Species Generation via Redox Cycling Promotes Apoptosis of Murine Pancreatic Acinar Cells*

Stuart Gillies, Mohammed Jaffar, R. Sutton, 2006, Journal of Biological Chemistry.

Heterocyclic analogues of L-citrulline as inhibitors of the isoforms of nitric oxide synthase (NOS) and identification of N(delta)-(4,5-dihydrothiazol-2-yl)ornithine as a potent inhibitor.

E. Chinje, I. Stratford, M. Jaffar, 1999, Bioorganic & medicinal chemistry.

Identification of a novel class of inhibitor of human and Escherichia coli thymidine phosphorylase by in silico screening.

M Jaffar, I. Stratford, M. Jaffar, 2003, Bioorganic & medicinal chemistry letters.

2-Cyclopropylindoloquinones and their analogues as bioreductively activated antitumor agents: structure-activity in vitro and efficacy in vivo.

G. Adams, I. Stratford, M. Jaffar, 1997, Journal of medicinal chemistry.

Bioreductive and gene therapy approaches to hypoxic diseases.

I. Stratford, M. Jaffar, K. Williams, 2001, Advanced drug delivery reviews.

Pharmacological and biological evaluation of a series of substituted 1,4-naphthoquinone bioreductive drugs.

I. Stratford, P. Cooper, P. Loadman, 2004, Biochemical pharmacology.

Targeting hypoxia with a new generation of indolequinones.

I. Stratford, M. Jaffar, M. Naylor, 1998, Anti-cancer drug design.

Effects of dietary salt loading on the responses of isolated rat mesenteric arteries to leptin.

R. Hainsworth, M. Jaffar, M. Drinkhill, 2005, American journal of hypertension.

The rôle of thymidine phosphorylase/PD-ECGF in cancer chemotherapy: a chemical perspective.

M. Jaffar, C. Cole, S. Freeman, 1999, Anti-cancer drug design.

The relative importance of NADPH: cytochrome c (P450) reductase for determining the sensitivity of human tumour cells to the indolequinone EO9 and related analogues lacking functionality at the C-2 and C-3 positions.

A. Harris, A. Patterson, I. Stratford, 2000, Biochemical pharmacology.

Fatty acid ethyl ester synthase inhibition ameliorates ethanol-induced Ca2+-dependent mitochondrial dysfunction and acute pancreatitis

W. Greenhalf, Wei Huang, R. Mukherjee, 2013, Gut.

Aminoimidazolylmethyluracil analogues as potent inhibitors of thymidine phosphorylase and their bioreductive nitroimidazolyl prodrugs.

S. Barry, S. Ashton, I. Stratford, 2005, Journal of medicinal chemistry.

Synthesis of N-benzyl- and N-phenyl-2-amino-4,5-dihydrothiazoles and thioureas and evaluation as modulators of the isoforms of nitric oxide synthase.

E. Chinje, I. Stratford, M. Jaffar, 2003, Bioorganic & medicinal chemistry.

A novel design strategy for stable metal complexes of nitrogen mustards as bioreductive prodrugs.

I. Stratford, J. Hartley, M. Jaffar, 2004, Journal of medicinal chemistry.

Viral delivery of P450 reductase recapitulates the ability of constitutive overexpression of reductase enzymes to potentiate the activity of mitomycin C in human breast cancer xenografts.

R. Airley, B. Telfer, I. Stratford, 2003, Molecular cancer therapeutics.

Time-dependence and preliminary SAR studies in inhibition of nitric oxide synthase isoforms by homologues of thiocitrulline.

E. Chinje, I. Stratford, M. Jaffar, 2003, Bioorganic & medicinal chemistry letters.

Thymidine phosphorylase from Escherichia coli: Tight-binding inhibitors as enzyme active-site titrants

M. Jaffar, K. Douglas, S. Freeman, 2006, Journal of enzyme inhibition and medicinal chemistry.

Antiangiogenic, bioreductive and gene therapy approaches to the treatment of hypoxic tumours.

I. Stratford, K. Williams, M. Jaffar, 2002, Current pharmaceutical design.

Indolequinone antitumor agents: reductive activation and elimination from (5-methoxy-1-methyl-4,7-dioxoindol-3-yl)methyl derivatives and hypoxia-selective cytotoxicity in vitro.

G. Adams, I. Stratford, M. Stratford, 1998, Journal of medicinal chemistry.

3-substituted-5-aziridinyl-1-methylindole-4,7-diones as NQO1-directed antitumour agents: mechanism of activation and cytotoxicity in vitro.

T. Ward, I. Stratford, K. Williams, 2003, Biochemical pharmacology.

Bioreductive drugs: selectivity towards hypoxic tissue

I. Stratford, M. Jaffar, 1999 .

Prodrugs for targeting hypoxic tissues: regiospecific elimination of aspirin from reduced indolequinones.

I. Stratford, M. Stratford, M. Jaffar, 1999, Bioorganic & medicinal chemistry letters.

Conformationally-restricted ligands for the histamine H1 receptor.

M. Jaffar, R. Osborne, C. Upton, 2000, Bioorganic & medicinal chemistry letters.

S-2-amino-5-azolylpentanoic acids related to L-ornithine as inhibitors of the isoforms of nitric oxide synthase (NOS).

E. Chinje, I. Stratford, M. Jaffar, 1998, Bioorganic & medicinal chemistry.

Potential tumor-selective nitroimidazolylmethyluracil prodrug derivatives: inhibitors of the angiogenic enzyme thymidine phosphorylase.

I. Stratford, M. Jaffar, K. Douglas, 2003, Journal of medicinal chemistry.

Synthesis and biological activity of analogues of batzelladine F

P. Murphy, A. Hizi, M. Jaffar, 2013 .

Stereochemical Studies of the Isomerization of Novel 2‐Alkyl‐9‐phenyl‐2,3,4,4a‐ and 2,3,4,9‐tetrahydro‐1H‐indeno[2,1‐c]pyridines

M. Jaffar, C. Upton, CHRISTOPHER UPTON, 1998, The Journal of pharmacy and pharmacology.

Improved Stereospecific Syntheses of Novel 1‐alkyl‐3‐benzoyl‐4‐hydroxy‐4‐phenylpiperidines

M. Jaffar, C. Upton, 1996, The Journal of pharmacy and pharmacology.

The 1,4-naphthoquinone scaffold in the design of cysteine protease inhibitors.

M. Jaffar, K. Douglas, R. Guedes, 2007, Bioorganic & medicinal chemistry.

Combining bioreductive drugs and radiation for the treatment of solid tumors.

I. Stratford, K. Williams, M. Jaffar, 2003, Seminars in radiation oncology.

The influence of tumour microenvironmental factors on the efficacy of cisplatin and novel platinum(IV) complexes.

M. Hall, T. Hambley, M. Jaffar, 2005, Biochemical pharmacology.

5-substituted analogues of 3-hydroxymethyl-5-aziridinyl-1-methyl-2-[1H-indole-4,7-dione]prop-2-en- 1-ol (EO9, NSC 382459) and their regioisomers as hypoxia-selective agents: structure-cytotoxicity in vitro.

G. Adams, I. Stratford, M. Jaffar, 1998, Anti-cancer drug design.

Bioreductive activation of a series of indolequinones by human DT-diaphorase: structure-activity relationships.

I. Stratford, M. Jaffar, S. Doughty, 1999, Journal of medicinal chemistry.

Quinone bioreductive prodrugs as delivery agents.

I. Stratford, M. Jaffar, Richard Tanner, 2004, Current drug delivery.

Design, synthesis and enzymatic evaluation of 6‐bridged imidazolyluracil derivatives as inhibitors of human thymidine phosphorylase

I. Stratford, M. Jaffar, K. Douglas, 2007, The Journal of pharmacy and pharmacology.

Calcium signalling and pancreatic cell death: apoptosis or necrosis?

M Jaffar, R Sutton, R. Sutton, 2007, Cell Death and Differentiation.

Chemical and bacterial reduction of azo-probes: monitoring a conformational change using fluorescence spectroscopy

N. Rattray, M. Jaffar, D. Mansell, 2013 .

Chemical synthesis and biological evaluation of a NAD(P)H:quinone oxidoreductase-1–targeted tripartite quinone drug delivery system

I. Stratford, P. Loadman, M. Jaffar, 2007, Molecular Cancer Therapeutics.

Synthesis and enzymatic evaluation of pyridinium-substituted uracil derivatives as novel inhibitors of thymidine phosphorylase.

I. Stratford, K. Williams, M. Jaffar, 2002, Bioorganic & medicinal chemistry.

D. Marks, I. Stratford, M. Jaffar, 1999, Anti-cancer drug design.

Synthesis and Enzymatic Evaluation of Pyridinium‐Substituted Uracil Derivatives as Novel Inhibitors of Thymidine Phosphorylase.

I. Stratford, K. Williams, M. Jaffar, 2002 .

Hypoxia Targeted Gene Therapy to Increase the Efficacy of Tirapazamine as an Adjuvant to Radiotherapy

B. Telfer, E. Chinje, I. Stratford, 2004, Cancer Research.

Relaxant and antispasmodic actions of methyleugenol on guinea-pig isolated ileum.

D. Criddle, M. Jaffar, C. C. Lima, 2000, Planta medica.

Inhibition of CA-IX modulates toxicity of mitomycin C in anoxic tumour cell lines.

I. Stratford, K. Williams, M. Jaffar, 2003 .

Comparative inhibitory effects of niflumic acid and novel synthetic derivatives on the rat isolated stomach fundus

D. Criddle, M. Jaffar, H. C. Scarparo, 2002, The Journal of pharmacy and pharmacology.

Oxygen-sensitive enzyme-prodrug gene therapy for the eradication of radiation-resistant solid tumours

R. Airley, B. Telfer, C. Wolf, 2002, Gene Therapy.

Hypoxia in tumors: molecular targets for anti-cancer therapeutics.

E. Chinje, I. Stratford, K. Williams, 2004, Advances in enzyme regulation.

An improved cell-permeable fluorogenic substrate as the basis for a highly sensitive test for NAD(P)H quinone oxidoreductase 1 (NQO1) in living cells.

E. Chinje, M. Jaffar, I. Weeks, 2018, Free radical biology & medicine.

Structural Requirements for EO9 Toxicity and Dependence on P450 Reductase for Activation

I. Stratford, M. Jaffar, M. Naylor, 1996 .