J. Dykens

发表

Circumventing the Crabtree effect: replacing media glucose with galactose increases susceptibility of HepG2 cells to mitochondrial toxicants.

Yvonne Will, L. Marroquin, J. Hynes, 2007, Toxicological sciences : an official journal of the Society of Toxicology.

Enzymic defenses against oxygen toxicity in marine Cnidarians containing endosymbiotic algae

J. Dykens, 1984 .

Oxygen radical production in the sea anemone Anthopleura elegantissima and its endosymbiotic algae

J. Dykens, G. Buettner, J. Shick, 1992 .

Predicting Drug‐Induced Hepatotoxicity: In Vitro, In Silico and In Vivo Approaches

Amit S. Kalgutkar, Jinghai J. Xu, Yvonne Will, 2009 .

Comprar Drug-Induced Mitochondrial Dysfunction | James A. Dykens | 9780470111314 | Wiley

J. Dykens, Y. Will, 2008 .

Drug-Induced Mitochondrial Dysfunction

J. Dykens, Y. Will, 2008 .

Relevance of purine catabolism to hypoxia and recovery in euryoxic and stenoxic marine invertebrates, particularly bivalve molluscs

J. Dykens, J. Shick, 1988 .

Preservation of phosphagen kinase function during transient hypoxia via enzyme abundance or resistance to oxidative inactivation

J. Dykens, R. Wiseman, C. Hardin, 2006, Journal of Comparative Physiology B.

Photoreceptor preservation in the S334ter model of retinitis pigmentosa by a novel estradiol analog.

S. Wiley, R. Wen, J. Dykens, 2004, Biochemical pharmacology.

Estrogens and Neuroprotection: desperate housewives, lost, and survivor

N. Howell, J. Dykens, W. Moos, 2005 .

17β‐ and 17α‐estradiol are non‐competitive inhibitors of dopamine uptake: implications for Parkinson's disease models and therapeutics

A. Sidhu, J. Dykens, C. Wersinger, 2005 .

Oxidative damage to human lens epithelial cells in culture: estrogen protection of mitochondrial potential, ATP, and cell viability.

J. Simpkins, J. Dykens, Xiaofei Wang, 2003, Investigative ophthalmology & visual science.

In vitro assessment of mitochondrial dysfunction and cytotoxicity of nefazodone, trazodone, and buspirone.

J. Xu, L. Marroquin, J. Dykens, 2008, Toxicological sciences : an official journal of the Society of Toxicology.

Mitochondrial toxicity assessment in industry – a decade of technology development and insight

J. Dykens, Y. Will, 2014, Expert opinion on drug metabolism & toxicology.

Regulation of polymorphonuclear leukocyte membrane fluidity: effect of cytoskeletal modification

J. Dykens, C. Wright, M. Wiles, 1994, Journal of leukocyte biology.

Human neutrophil (PMN) oxygen radical production and the cytoskeleton.

J. Dykens, C. Wright, M. Wiles, 1995, Life sciences.

Review of the effects of 17α‐estradiol in humans: a less feminizing estrogen with neuroprotective potential

N. Howell, J. Dykens, W. Moos, 2009 .

Neuroprotective Effects of 17β-Estradiol and Nonfeminizing Estrogens against H2O2 Toxicity in Human Neuroblastoma SK-N-SH Cells

J. Simpkins, Shao-Hua Yang, Ran Liu, 2006, Molecular Pharmacology.

Development of 17α‐Estradiol as a Neuroprotective Therapeutic Agent: Rationale and Results from a Phase I Clinical Study

N. Howell, J. Dykens, W. Moos, 2005, Annals of the New York Academy of Sciences.

Mitochondria play a central role in estrogen-induced neuroprotection.

J. Simpkins, L. Prokai, J. Dykens, 2005, Current drug targets. CNS and neurological disorders.

PHOTOBIOLOGY OF THE SYMBIOTIC SEA ANEMONE ANTHOPLEURA ELEGANTISSIMA: PHOTOSYNTHESIS, RESPIRATION, AND BEHAVIOR UNDER INTERTIDAL CONDITIONS

J. Dykens, J. Shick, 1984 .

Streptococcal cell wall-induced arthritis. Requirements for neutrophils, P-selectin, intercellular adhesion molecule-1, and macrophage-inflammatory protein-2.

P. Ward, J. Dykens, C. Flory, 1997, Journal of immunology.

Mitochondrial oxidative phosphorylation is a downstream regulator of nitric oxide effects on chondrocyte matrix synthesis and mineralization.

R. Terkeltaub, J. Dykens, A. Andreyev, 2000, Arthritis and rheumatism.

The significance of mitochondrial toxicity testing in drug development.

Yvonne Will, J. Dykens, Y. Will, 2007, Drug discovery today.

Mitochondrial localization of estrogen receptor β

Anne-Marie Brun-Zinkernagel, Yvonne Will, Peter Koulen, 2004, Proceedings of the National Academy of Sciences of the United States of America.

A current practice for predicting ocular toxicity of systemically delivered drugs

Nigel Greene, M. Aleo, N. Greene, 2009, Cutaneous and ocular toxicology.

Purineolytic capacity and origin of hemolymph urate in Carcinus maenas during hypoxia

J. Dykens, 1991 .

Glucose metabolism and hemoglobin reactivity in human red blood cells exposed to the tryptophan metabolites 3-hydroxyanthranilate, quinolinate and picolinate.

A. Stern, J. Dykens, S. G. Sullivan, 1989, Biochemical pharmacology.

Oxidative reactivity of the tryptophan metabolites 3-hydroxyanthranilate, cinnabarinate, quinolinate and picolinate.

A. Stern, J. Dykens, S. G. Sullivan, 1987, Biochemical pharmacology.

PHOTOBIOLOGY OF THE SYMBIOTIC SEA ANEMONE, ANTHOPLEURA ELEGANTISSIMA: DEFENSES AGAINST PHOTODYNAMIC EFFECTS, AND SEASONAL PHOTOACCLIMATIZATION.

J. Dykens, J. Shick, 1984, The Biological bulletin.

The regulation of body fluid volume in the estuarine annelidNereis succinea

C. Mangum, J. Dykens, 1984, Journal of Comparative Physiology B.

The excretion of NH4+ and its ouabain sensitivity in aquatic annelids and molluscs

C. Mangum, J. Dykens, R. Henry, 1978 .

The design of cardiac muscle and the mode of metabolism in molluscs

C. Mangum, J. Dykens, 1979 .

Mechanism of Kainate Toxicity to Cerebellar Neurons In Vitro Is Analogous to Reperfusion Tissue Injury

A. Stern, J. Dykens, E. Trenkner, 1987, Journal of neurochemistry.

Effect of the multitargeted tyrosine kinase inhibitors imatinib, dasatinib, sunitinib, and sorafenib on mitochondrial function in isolated rat heart mitochondria and H9c2 cells.

B. Jessen, L. Marroquin, J. Hynes, 2008, Toxicological sciences : an official journal of the Society of Toxicology.

Mitochondrial mechanisms of estrogen neuroprotection

J. Simpkins, J. Dykens, 2008, Brain Research Reviews.

Urinary 8-hydroxydeoxyguanosine excretion as a non-invasive marker of neutrophil activation in animal models of inflammatory bowel disease.

J. Dykens, T. Baginski, 1998, Scandinavian journal of gastroenterology.

Biguanide-induced mitochondrial dysfunction yields increased lactate production and cytotoxicity of aerobically-poised HepG2 cells and human hepatocytes in vitro.

L. Marroquin, J. Dykens, J. Jamieson, 2008, Toxicology and applied pharmacology.

Free Radicals and Mitochondria Dysfunction in Excitotoxicity and Neurodegenerative Disease

J. Dykens, 1999 .

Introduction to Mitochondrial Toxicity

J. Dykens, Y. Will, 2009 .

Isolated Cerebral and Cerebellar Mitochondria Produce Free Radicals when Exposed to Elevated Ca2+ and Na+: Implications for Neurodegeneration

J. Dykens, 1994, Journal of neurochemistry.

High-throughput assessment of mitochondrial membrane potential in situ using fluorescence resonance energy transfer.

Soumitra S Ghosh, M. Ward, J. Dykens, 2002, Mitochondrion.

Assessment of mitochondrial membrane potential in situ using single potentiometric dyes and a novel fluorescence resonance energy transfer technique.

J. Dykens, A. Stout, 2001, Methods in Cell Biology.

Biomarkers of in Vitro Drug‐Induced Mitochondrial Dysfunction

J. Dykens, Y. Will, 2010 .

Strategies to reduce late-stage drug attrition due to mitochondrial toxicity

Yvonne Will, L. Marroquin, J. Dykens, 2007, Expert review of molecular diagnostics.

17α‐estradiol: a less‐feminizing estrogen

N. Howell, J. Dykens, W. Moos, 2008 .

Alzheimer's disease, estrogens, and clinical trials: a case study in drug development for complex disorders

N. Howell, J. Dykens, W. Moos, 2005 .

Novel Mechanisms for Estrogen-Induced Neuroprotection

J. Simpkins, Meharvan Singh, J. Dykens, 2006, Experimental biology and medicine.

Mitochondrial localization of estrogen receptor beta.

Anne-Marie Brun-Zinkernagel, Yvonne Will, Peter Koulen, 2004, Proceedings of the National Academy of Sciences of the United States of America.

Mitochondrial mechanisms of estrogen neuroprotection.

J. Simpkins, Shao-Hua Yang, J. Dykens, 2010, Biochimica et biophysica acta.

Oxygen production by endosymbiotic algae controls superoxide dismutase activity in their animal host

J. Dykens, J. Shick, 1982, Nature.

Oxygen detoxification in algal-invertebrate symbioses from the Great Barrier Reef

J. Dykens, J. Shick, 1985, Oecologia.

Mitochondrial impairment by PPAR agonists and statins identified via immunocaptured OXPHOS complex activities and respiration.

R. Capaldi, J. Dykens, Y. Will, 2007, Toxicology and applied pharmacology.

Mitochondrial dysfunction caused by drug and environmental toxicants

J. Dykens, Y. Will, 2020 .

Polycyclic phenols, estrogens and neuroprotection: a proposed mitochondrial mechanism

J. Simpkins, J. Dykens, J. Wang, 2003, Experimental Gerontology.

Neuroprotective effects of 17beta-estradiol and nonfeminizing estrogens against H2O2 toxicity in human neuroblastoma SK-N-SH cells.

J. Simpkins, Shao-Hua Yang, Ran Liu, 2006, Molecular pharmacology.

Mitochondrial Drugs Come of Age

Walter H Moos, J. Dykens, W. Moos, 2015, Drug development research.

Introduction to mitochondrial function and genomics

J. Dykens, W. Moos, R. Davis, 1999 .